AU3259197A - 7-(3-Vinyl-1,4-piperazin-1-yl)-substituted quinolonecarboxylic acids - Google Patents

7-(3-Vinyl-1,4-piperazin-1-yl)-substituted quinolonecarboxylic acids

Info

Publication number
AU3259197A
AU3259197A AU32591/97A AU3259197A AU3259197A AU 3259197 A AU3259197 A AU 3259197A AU 32591/97 A AU32591/97 A AU 32591/97A AU 3259197 A AU3259197 A AU 3259197A AU 3259197 A AU3259197 A AU 3259197A
Authority
AU
Australia
Prior art keywords
stands
hydrogen
carbon atoms
methyl
vinyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU32591/97A
Other versions
AU720322B2 (en
Inventor
Werner Hallenbach
Ernst Heinen
Thomas Himmler
Thomas Jaetsch
Franz Pirro
Hans-Georg Rast
Martin Scheer
Michael Stegemann
Hans-Peter Stupp
Heinz-Georg Wetzstein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19651687A external-priority patent/DE19651687A1/en
Application filed by Bayer AG filed Critical Bayer AG
Publication of AU3259197A publication Critical patent/AU3259197A/en
Application granted granted Critical
Publication of AU720322B2 publication Critical patent/AU720322B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The invention concerns new quinolone carbonic acids substituted by 7-(3-vinyl-1,4-piperazine-1-yl) of general formula (I) in which R<1> stands for hydrogen or alkyl optionally substituted by hydroxy, methoxy, amino, methylamino or dimethylamino with 1 to 4 carbon atoms or (5-methyl-2-oxo-1,3-dioxol-4-yl)-methyl; R<2> stands for hydrogen or fluorine when at the same time R<4> is a different hydrogen or fluorine, or stands for amino, methyl or vinyl; R<3> stands for hydrogen, benzyl, alkyl with 1 to 3 carbon atoms, groups of -CH=CH-COOR<5>, -CH2CH2-COOR<5>, -CH2CH2CN, -CH2CH2COCH3, -CH2COCH3, in which R<5> stands for methyl or ethyl or stands for a group of the general structure R<6>-(NH-CHR<7>-CO)n- in which R<6> stands for hydrogen, alkyl with 1 to 3 carbon atoms or stands for the -COO-tertiary butyl group, R<7> stands for hydrogen, alkyl with 1 to 4 carbon atoms, hydroxyalkyl with 1 or 2 carbon atoms, CH2-phenyl, aminoalkyl or thioalkyl with 1 or 2 carbon atoms and n = 1 or 2; and R<4> stands for hydrogen or flourine when R<2> stands for amino, methyl or vinyl or stands for chlorine, methoxy, difluoromethoxy, CN or ethinyl. The invention also concerns a method for their use and their use in antibacterial substances.
AU32591/97A 1996-06-28 1997-06-16 7-(3-Vinyl-1,4-piperazin-1-yl)-substituted quinolonecarboxylic acids Ceased AU720322B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE19625988 1996-06-28
DE19625988 1996-06-28
DE19651687 1996-12-12
DE19651687A DE19651687A1 (en) 1996-06-28 1996-12-12 7- (3-Vinyl-1,4-piperazin-1-yl) substituted quinolonecarboxylic acids
PCT/EP1997/003116 WO1998000421A1 (en) 1996-06-28 1997-06-16 Quinolone carboxylic acids substituted by 7-(3-vinyl-1,4-piperazine-1-yl)

Publications (2)

Publication Number Publication Date
AU3259197A true AU3259197A (en) 1998-01-21
AU720322B2 AU720322B2 (en) 2000-05-25

Family

ID=26027015

Family Applications (1)

Application Number Title Priority Date Filing Date
AU32591/97A Ceased AU720322B2 (en) 1996-06-28 1997-06-16 7-(3-Vinyl-1,4-piperazin-1-yl)-substituted quinolonecarboxylic acids

Country Status (10)

Country Link
EP (1) EP0907648B1 (en)
JP (1) JP2000513368A (en)
AT (1) ATE214060T1 (en)
AU (1) AU720322B2 (en)
BR (1) BR9710005A (en)
CA (1) CA2259217A1 (en)
ES (1) ES2171952T3 (en)
NZ (1) NZ333578A (en)
TW (1) TW415943B (en)
WO (1) WO1998000421A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10337191A1 (en) * 2003-08-13 2005-03-17 Bayer Healthcare Ag New use of quinolone antibiotics

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0230053A3 (en) * 1986-01-17 1988-03-30 American Cyanamid Company 7-(substituted)piperazinyl-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids

Also Published As

Publication number Publication date
EP0907648B1 (en) 2002-03-06
ES2171952T3 (en) 2002-09-16
NZ333578A (en) 2000-08-25
TW415943B (en) 2000-12-21
AU720322B2 (en) 2000-05-25
JP2000513368A (en) 2000-10-10
BR9710005A (en) 1999-08-10
WO1998000421A1 (en) 1998-01-08
EP0907648A1 (en) 1999-04-14
CA2259217A1 (en) 1998-01-08
ATE214060T1 (en) 2002-03-15

Similar Documents

Publication Publication Date Title
BR0212042A (en) Compound, pharmaceutical composition, method of treating or preventing disease, and use of a compound
MY138797A (en) Bacterial gyrase inhibitors and uses thereof
MXPA02012033A (en) 2-aminocarbonyl-9h-purine derivatives.
IL126339A0 (en) Taxol derivatives
WO2005013914A8 (en) Heteroarylaminosulfonylphenyl derivatives for use as sodium or calcium channel blockers in the treatment of pain
AU7490900A (en) Chemical compounds and compositions and their use as cathepsin s inhibitors
AU4064597A (en) Amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof
WO2001035950A3 (en) Benzamide therapeutics and methods for treating inflammatory bowel disease
YU41199A (en) Quinoxalinediones
AU2002213421A1 (en) Condensed pyridoindole derivatives
DE60205899D1 (en) 1-biaryl-1,8-naphthyridin-4-one als phosphodieseterase-inhibitoren
CA2238875A1 (en) Tri-aryl ethane derivatives as pde iv inhibitors
WO2002070524A3 (en) N-but-3-enyl norbuprenorphine and its use as analgesic
GEP20053626B (en) Substituted 8-Arylquinoline Phosphodiesterase-4 Inhibitors, Pharmaceutical Composition Containing Them and Use Thereof
IL163625A0 (en) Alkoxy-pyridine derivatives and pharmaceutical compositions containing the same
AU1367497A (en) Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical composition for the treatment or prophylaxis of prostatic carcinoma
EP1262196A3 (en) Combination of a monoamine reuptake inhibitor and an opioid antagonist for use in alcoholism and alcohol dependence
WO1998027930A3 (en) New use of aminopiperazine derivatives
WO2002051848A3 (en) Sulfamidothienopyrimidines and the use of the same as phosphodiesterase v inhibitors
AU3259197A (en) 7-(3-Vinyl-1,4-piperazin-1-yl)-substituted quinolonecarboxylic acids
MXPA02004441A (en) Isoxazole derivatives to be used as phosphodiesterase vii inhibitors.
BG104034A (en) Method for the preparation of pharmaceutical compounds of antidepressive effect and against the parkinson syndrome effect
WO2000010998A3 (en) Pyridone antibiotic with improved safety profile
PT1282617E (en) Hydantoin derivatives with affinity for somatostatin receptors
MY129094A (en) Condensed polycyclic compounds

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired