AU3255589A - Amino acid derivatives - Google Patents

Amino acid derivatives

Info

Publication number
AU3255589A
AU3255589A AU32555/89A AU3255589A AU3255589A AU 3255589 A AU3255589 A AU 3255589A AU 32555/89 A AU32555/89 A AU 32555/89A AU 3255589 A AU3255589 A AU 3255589A AU 3255589 A AU3255589 A AU 3255589A
Authority
AU
Australia
Prior art keywords
amino acid
acid derivatives
derivatives
amino
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU32555/89A
Other versions
AU618335B2 (en
Inventor
Joachim Dr. Gante
Klaus-Otto Dr. Minck
Peter Dr. Raddatz
Claus J. Dr. Schmitges
Johannes Dr. Sombroek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of AU3255589A publication Critical patent/AU3255589A/en
Application granted granted Critical
Publication of AU618335B2 publication Critical patent/AU618335B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/38Drugs for disorders of the endocrine system of the suprarenal hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU32555/89A 1988-04-14 1989-04-07 Amino acid derivatives Ceased AU618335B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3812328A DE3812328A1 (en) 1988-04-14 1988-04-14 AMINOSAEUREDERIVATE
DE3812328 1988-04-14

Publications (2)

Publication Number Publication Date
AU3255589A true AU3255589A (en) 1989-10-19
AU618335B2 AU618335B2 (en) 1991-12-19

Family

ID=6351910

Family Applications (1)

Application Number Title Priority Date Filing Date
AU32555/89A Ceased AU618335B2 (en) 1988-04-14 1989-04-07 Amino acid derivatives

Country Status (12)

Country Link
EP (1) EP0337334A3 (en)
JP (1) JPH026449A (en)
KR (1) KR890016062A (en)
CN (1) CN1037155A (en)
AU (1) AU618335B2 (en)
DE (1) DE3812328A1 (en)
DK (1) DK177789A (en)
FI (1) FI891761A (en)
HU (1) HU206888B (en)
NZ (1) NZ228707A (en)
PT (1) PT90273B (en)
ZA (1) ZA892720B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU610588B2 (en) * 1987-05-26 1991-05-23 Merck Patent Gesellschaft Mit Beschrankter Haftung Amino acid derivatives

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991006561A1 (en) * 1989-10-27 1991-05-16 The Upjohn Company Method for treating hiv and other retroviruses and compounds useful therefor
TW209870B (en) * 1990-01-18 1993-07-21 Pfizer
EP0483403A1 (en) * 1990-10-31 1992-05-06 Hoechst Aktiengesellschaft Derivatives of amino acids as inhibitors of renin, methods for their preparation, medicaments containing them and their use
US5442044A (en) * 1991-01-04 1995-08-15 Pfizer Inc. Orally active renin inhibitors
PT101026A (en) * 1991-11-01 1994-05-31 Smithkline Beecham Corp 6-PHENYL-5-AMINO-4-HYDROXY-HEXANOYL-VALYL-GUANIDINES SUBSTITUTED AS HIV PROTEASE INHIBITORS
KR20140053855A (en) 2011-02-08 2014-05-08 메르크 파텐트 게엠베하 Aminostatin derivatives for the treatment of arthrosis
CN104507957B (en) 2012-07-24 2018-12-25 默克专利股份有限公司 For treating the hydroxyl statin derivative of arthropathy

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL81234A (en) * 1986-01-16 1992-09-06 Abbott Lab Peptidylaminodiols,process for their preparation and pharmaceutical compositions comprising them
DE3601248A1 (en) * 1986-01-17 1987-07-23 Hoechst Ag SUBSTITUTED 4-AMINO-3-HYDROXYBUTTERIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THESE AGENTS AND THEIR USE
ES2066755T3 (en) * 1986-06-10 1995-03-16 Merck Patent Gmbh DERIVATIVES OF RENINE INHIBITING AMINO ACIDS.
DE3721855A1 (en) * 1987-03-12 1988-09-22 Merck Patent Gmbh AMINO ACID DERIVATIVES

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU610588B2 (en) * 1987-05-26 1991-05-23 Merck Patent Gesellschaft Mit Beschrankter Haftung Amino acid derivatives

Also Published As

Publication number Publication date
KR890016062A (en) 1989-11-28
HU206888B (en) 1993-01-28
FI891761A0 (en) 1989-04-13
JPH026449A (en) 1990-01-10
NZ228707A (en) 1992-03-26
CN1037155A (en) 1989-11-15
DK177789D0 (en) 1989-04-13
PT90273A (en) 1989-11-10
EP0337334A2 (en) 1989-10-18
EP0337334A3 (en) 1992-05-20
AU618335B2 (en) 1991-12-19
PT90273B (en) 1994-07-29
ZA892720B (en) 1989-12-27
HUT52786A (en) 1990-08-28
DE3812328A1 (en) 1989-10-26
FI891761A (en) 1989-10-15
DK177789A (en) 1989-10-15

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