AU2504192A - Protein kinase c inhibition and novel compound balanol - Google Patents

Protein kinase c inhibition and novel compound balanol

Info

Publication number
AU2504192A
AU2504192A AU25041/92A AU2504192A AU2504192A AU 2504192 A AU2504192 A AU 2504192A AU 25041/92 A AU25041/92 A AU 25041/92A AU 2504192 A AU2504192 A AU 2504192A AU 2504192 A AU2504192 A AU 2504192A
Authority
AU
Australia
Prior art keywords
balanol
inhibition
protein kinase
novel compound
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU25041/92A
Inventor
Lawrence M Ballas
Christie Boros
Yali F. Hallock
William P Janzen
Palaniappan Kulanthivel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Sphinx Pharmaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sphinx Pharmaceuticals Corp filed Critical Sphinx Pharmaceuticals Corp
Publication of AU2504192A publication Critical patent/AU2504192A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/12—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
AU25041/92A 1991-08-22 1992-08-21 Protein kinase c inhibition and novel compound balanol Abandoned AU2504192A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US748632 1985-06-24
US74863291A 1991-08-22 1991-08-22

Publications (1)

Publication Number Publication Date
AU2504192A true AU2504192A (en) 1993-03-16

Family

ID=25010269

Family Applications (1)

Application Number Title Priority Date Filing Date
AU25041/92A Abandoned AU2504192A (en) 1991-08-22 1992-08-21 Protein kinase c inhibition and novel compound balanol

Country Status (5)

Country Link
EP (1) EP0664706A1 (en)
JP (1) JPH06510280A (en)
AU (1) AU2504192A (en)
CA (1) CA2115994A1 (en)
WO (1) WO1993003730A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6252794A (en) * 1993-03-03 1994-09-26 Eli Lilly And Company Balanoids
AU686691B2 (en) * 1994-01-12 1998-02-12 F. Hoffmann-La Roche Ag Novel azepanes and homologs thereof
US5583221A (en) * 1994-05-04 1996-12-10 Eli Lilly And Company Substituted fused and bridged bicyclic compounds as therapeutic agents
TW339325B (en) * 1995-07-05 1998-09-01 Hoffmann La Roche Novel azepane derivatives, process for the preparation thereof and pharmaceutical composition containing the same
JP2000504672A (en) * 1996-02-09 2000-04-18 フィテラ シンビオン エイピーエス Balanol analogues
US6914140B1 (en) 1996-04-17 2005-07-05 Hoffmann-La Roche Inc. Asymmetric synthesis process
US5902882A (en) * 1996-04-17 1999-05-11 Hoffmann-La Roche Inc. Assymetric synthesis of azepines
US6232299B1 (en) * 1996-05-01 2001-05-15 Eli Lilly And Company Use of protein kinase C inhibitors to enhance the clinical efficacy of oncolytic agents and radiation therapy
ES2696598T3 (en) * 2005-03-21 2019-01-17 Univ Columbia Balancer compounds for use in the treatment of pain
US8846742B2 (en) 2006-02-14 2014-09-30 The Trustees Of Columbia University In The City Of New York Neuronal pain pathway modulators

Also Published As

Publication number Publication date
EP0664706A4 (en) 1995-06-14
JPH06510280A (en) 1994-11-17
WO1993003730A1 (en) 1993-03-04
EP0664706A1 (en) 1995-08-02
CA2115994A1 (en) 1993-03-04

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