AU2021106230A4 - Medicinal diet composition for preventing and treating hyperuricemia and gout and preparation method thereof - Google Patents
Medicinal diet composition for preventing and treating hyperuricemia and gout and preparation method thereof Download PDFInfo
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- AU2021106230A4 AU2021106230A4 AU2021106230A AU2021106230A AU2021106230A4 AU 2021106230 A4 AU2021106230 A4 AU 2021106230A4 AU 2021106230 A AU2021106230 A AU 2021106230A AU 2021106230 A AU2021106230 A AU 2021106230A AU 2021106230 A4 AU2021106230 A4 AU 2021106230A4
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- gout
- preventing
- diet composition
- treating hyperuricemia
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Abstract
The invention provides a medicinal diet composition for preventing and treating
hyperuricemia and gout, which is prepared from the following raw materials in parts by
weight:1-15 parts of Cichorium intybus L., 1-15 parts of Symphytum officinale L, 1-20
parts of Phyllanthus emblica, 1-15 parts of Sophora japonica L., 1-20 parts of Pueraria
lobata, 1-15 parts of Perilla frutescens , 1-10 parts of Chrysanthemum indicum L., 1
15 parts of Folium Mori, 1-15 parts of Prunus mume, 1-20 parts of tuckahoe, 1-20 parts
of Lilium lancifolium , 0.1 to 1 part of folic acid, 0.1 to 1.5 parts of chitosan
oligosaccharide, 0.5-5 parts of xylooligosaccharide. The invention provides a
preparation method of the medicinal diet composition for preventing and treating
hyperuricemia and gout. The medicinal diet composition for preventing and treating
hyperuricemia and gout has the advantages of clear curative effect, clear action target
and pharmacological effect, wide raw material sources, low cost and simple
preparation method, and can intervene various links of gout and hyperuricemia with
multiple components, multiple targets, multiple paths and multiple angles to
cooperatively prevent and treat this chronic disease.
Description
Medicinal diet composition for preventing and treating hyperuricemia and gout and preparation method thereof
TECHNICAL FIELD The invention belongs to the technical field of health care products, and particularly relates to medicinal diet composition for preventing and treating hyperuricemia and gout and preparation method thereof
BACKGROUND Hyperruriceemia (HUA) means that the blood uric acid level of men and women is higher than 420pmol/L and 360pmol/L on two different fasting days under normal purine diet. Long-term elevation of uric acid often leads to arthritis damage, gout and impaired renal function. The latest research shows that the prevalence rate of hyperuricemia in China is 16.85%, and the number of hyperuricemia patients has reached 236 million. At present, western medicines for lowering uric acid have great adverse reactions, often accompanied by obvious gastrointestinal reactions, liver and kidney function damage, neurotoxicity and muscle toxicity, and exfoliative dermatitis appears in severe cases. Traditional Chinese medicine treatment of this disease has the advantages of definite clinical efficacy, high safety and little toxic and side effects. Traditional Chinese medicine is considered to have a clear curative effect on hyperuricemia and gout. Besides clinical prescriptions, Chinese patent medicines are also recommended for the prevention and treatment of hyperuricemia and gout, such as Tongfengding Tablet, Tongfengshu Tablet, Compound Shenjin Capsule, Simiao Pill, etc. However, these are all pharmaceutical products, which need to be used under the guidance of clinicians or pharmacists. There are few related medicine and food homologous products. Therefore, the products with medicine and food to reduce uric acid and prevent gout have broad prospects.
SUMMARY The technical problem to be solved by the invention lies in overcoming the defects of the prior art and providing a medicinal diet composition for preventing and treating hyperuricemia and gout and a preparation method thereof. The invention provides a medicinal diet composition for preventing and treating hyperuricemia and gout, which is prepared from the following raw materials in parts by weight:1-15 parts of Cichorium intybus L., 1-15 parts of Symphytum officinale L, 1-20 parts of Phyllanthus emblica, 1-15 parts of Sophora japonica L., 1-20 parts of Pueraria lobata, 1-15 parts of Perilla frutescens , 1-10 parts of Chrysanthemum indicum L., 1-15 parts of Folium Mori, 1-15 parts of Prunus mume, 1-20 parts of tuckahoe, 1-20 parts of Lilium lancifolium , 0.1-1 part of folic acid, 0.1-1.5 parts of chitosan oligosaccharide, 0.5 parts of xylooligosaccharide. And the preparation method of the medicinal diet composition for preventing and treating hyperuricemia and gout comprises the following steps: Weighing raw materials according to the weight parts of the medicinal diet composition for preventing and treating hyperuricemia and gout, mixing Cichorium intybus L., Symphytum officinale L, Phyllanthus emblica, Sophora japonica L., Pueraria lobata, Perilla frutescens
, Chrysanthemum indicum L. flower, mulberry leaf, Prunus mume, poria cocos and Lilium lancifolium , soaking in 10-20 times of water for 15-60 minutes, heating and refluxing for 0.5-2 hours, and filtering with 80-200 meshes Obtaining a first extracting solution. Adding 10-20 times of water into the dregs, refluxing and extracting for 0.5-2 hours, and filtering with 80-200 meshes to obtain a second extracting solution. Mixing the first extracting solution and the second extracting solution, concentrating, and adding folic acid, chitosan oligosaccharide and xylooligosaccharide to obtain the medicated diet composition for preventing and treating hyperuricemia and gout. The medicated diet composition for preventing and treating hyperuricemia and gout of the present invention can eliminate turbidity and promote diuresis, reduce acid and prevent arthralgia. To prevent and treat hyperuricemia and gout, it has obvious inhibitory activity on adenosine deaminase (ADA) and xanthine oxidase (XOD), two key targets of uric acid production, and significantly enhances the expression of uric acid transporter, the core target of uric acid excretion. The medicinal diet composition for preventing and treating hyperuricemia and gout has the characteristics of clear curative effect, convenient use, clear action target and pharmacological effect, wide source of raw materials, low cost, simple preparation method, high patient compliance and the like, and is suitable for patients with hyperuricemia and ventilation.
BRIEF DESCRIPTION OF THE FIGURES Fig. 1 is an association network diagram of traditional Chinese medicine raw materials-active ingredients-action targets of a medicinal diet composition for preventing and treating hyperuricemia and gout provided by an embodiment of the present invention.
DESCRIPTION OF THE INVENTION In order to make the object, technical scheme and advantages of the present invention clearer, the present invention will be further described in detail with reference to the drawings and examples. It should be understood that the specific embodiments described herein are only used to explain the present invention, and are not used to limit the present invention. The embodiment of the invention provides a medicinal diet composition for preventing and treating hyperuricemia and gout, which is prepared from the following raw materials in parts by weight: 1-15 parts of Cichorium intybus L., 1-15 parts of Symphytum officinale L, 1-20 parts of Phyllanthus emblica, 1-15 parts of Sophora japonica L., 1-20 parts of Pueraria lobata, 1-15 parts of Perilla frutescens , 1-10 parts of Chrysanthemum indicum L., 1-15 parts of Folium Mori, 1-15 parts of Prunus mume, 1-20 parts of tuckahoe, 1-20 parts of Lilium lancifolium , 0.1-1 part of folic acid, 0.1-1.5 parts of chitosan oligosaccharide, 0.5-5 parts of xylooligosaccharide. Wherein, quercetin from Cichorium intybus L., Symphytum officinale L and Sophora japonica L. can inhibit the release of inflammatory factors such as TNFa and IL-1P, inhibit the activation of inflammatory corpuscles of NF-KB and NLRP3, and resist gout arthritis induced by monosodium urate crystals in rodents. Puerarin and kaempferol extract from Pueraria lobata can improve antioxidant function, inhibit xanthine oxidase, reduce uric acid formation and promote uric acid metabolism. Luteolin-7-o-glucoside, apigenin-7-o glucoside, luteolin and apigenin in Chrysanthemum indicum were also proved to be inhibitors of xanthine oxidase, with IC50 of 23.61, 38.80, 1.54 and 1.96pM respectively, suggesting that Chrysanthemum indicum indicum can inhibit the formation of uric acid and prevent hyperuricemia. Molecular docking experiments further confirmed that kaempferol, an active ingredient contained in many traditional Chinese medicines (such as Chennai, Mume and Sophora japonica L.), occupied the catalytic active site of xanthine oxidase and competitively and reversibly inhibited xanthine oxidase. The research of network pharmacology suggests that the medicinal diet composition for preventing and treating hyperuricemia and gout can intervene in various links of gout and hyperuricemia with multi-components, multi-targets, multi-channels and multi angles, and cooperatively prevent and treat this chronic disease. The prescription adopts all food-grade raw materials, which is safe, effective, low in production cost and reliable in prevention effect. It can effectively prevent and treat related symptoms caused by high uric acid gout, and is an accurate medicated diet product with clear main components and clear target points. Preferably, Medicinal diet composition for preventing and treating hyperuricemia and gout and preparation method thereof is characterized in that the medicated diet composition is prepared from the following raw materials in parts by weight: 8-10 parts of Cichorium intybus L., 5-7 parts of Symphytum officinale L, 8-10 parts of Phyllanthus emblica, 8-10 parts of Sophora japonica L., 8-10 parts of Pueraria lobata, 8-10 parts of Perilla frutescens , 5-7 parts of Chrysanthemum indicum L., 8-10 parts of Folium Mori, -7 parts of Prunus mume, 8-10 parts of tuckahoe, 8-10 parts of Lilium lancifolium , 0.2 0.4part of folic acid, 0.4-0.6 parts of chitosan oligosaccharide, 0.8-1.2 parts of xylooligosaccharide. More preferably, medicinal diet composition for preventing and treating hyperuricemia and gout and preparation method thereof is characterized in that the medicated diet composition is prepared from the following raw materials in parts by weight: 9 parts of Cichorium intybus L., 6 parts of Symphytum officinale L, 9 parts of Phyllanthus emblica, 9 parts of Sophora japonica L., 9 parts of Pueraria lobata, 9 parts of Perilla frutescens , 6 parts of Chrysanthemum indicum L., 9 parts of Folium Mori, 6 parts of Prunus mume, 9 parts of tuckahoe, 9 parts of Lilium lancifolium , 0.3 part of folic acid, 0.5 parts of chitosan oligosaccharide,1 part of xylooligosaccharide. The prescription adopts all food-grade raw materials, which is safe and effective, low in production cost and reliable in prevention effect. As shown in fig. 1, the network pharmacology research preliminarily defined the action relationship network of the main disease-target-pharmacodynamic components, and defined the physiological/pathological pathway process involved in the action. At the same time, the research results of the component-target-pharmacological action mechanism network of the medicinal diet composition for preventing and treating hyperuricemia and gout are consistent with the main disease, which conforms to the principle of modern precision medicine. In addition, this product has low cost and meets the needs of industrial production. The embodiment of the invention also provides a preparation method of the medicinal diet composition for preventing and treating hyperuricemia and gout, which comprises the following steps: Weighing raw materials according to the weight parts of the medicinal diet composition for preventing and treating Cichorium intybus L., Symphytum officinale L, Phyllanthus emblica, Sophora japonica L., Pueraria lobata, Perilla frutescens, Chrysanthemum indicum L., Folium Mori, Prunus mume, tuckahoe, Lilium lancifolium, soaking the material in 10-20 times of water for 15-60 minutes, heating and refluxing for 0.5-2 hours, and filtering with 80-200 meshes.Obtaining a first extracting solution. Adding 10-15 times of water into the dregs, heating, refluxing and extracting for 0.5 2 hours, and filtering with 100-200 meshes to obtain a second extracting solution. More specifically, in the medicinal diet composition for preventing and treating hyperuricemia and gout, the mixed solution of the two extraction solutions is concentrated under reduced pressure until the density is about 1.08 to obtain concentrated solution for later use. Adding maltodextrin into the concentrated solution, stirring uniformly, and spray drying (the inlet temperature of the nozzle is set at 150°C, and the outlet temperature is set at 80°C) to obtain extract powder for later use. Adding folic acid, chitooligosaccharides and xylooligosaccharides into the described dry powder, and mixing uniformly. Packaging the obtained product as 10g/bag, to obtain solid beverage. Or adding folic acid, chitosan oligosaccharide and xylooligosaccharide into the spray-dried powder, granulating, drying, packaging the obtained product as10g/ bag, and making into granules. Use dry powder, add folic acid, chitosan oligosaccharide and xylooligosaccharide and other suitable food raw materials, granulate, dry and making into suitable tablet form. The final forms of products can be various, including powder, granule, tablet, honeyed pill, ointment, oral liquid, syrup, etc. In the preparation process, the drying methods can be spray drying, vacuum drying, freeze drying, etc. Granulation methods can be dry granulation, wet granulation, one-step granulation, etc. The above medicinal diet composition for preventing and treating hyperuricemia and gout can be extracted, concentrated, dried or crushed by methods acceptable by relevant laws and regulations such as pharmacy, food and health care products, and further processed into products, retaining the effective components of the compound, and making into suitable administration forms (including granules, powder, oral liquid, tablets and other dosage forms) or food forms such as tabletted candy, meal powder, solid drink and other forms, meeting the market demand for related products, all of which are within the protection scope of this invention. The medicinal diet composition for preventing and treating hyperuricemia and gout and the preparation method thereof are explained by the examples of specific formula and preparation process below. Embodiment 1 Weigh 9kg of Cichorium intybus L., 6kg of Symphytum officinale L, 9kg of Phyllanthus emblica,9kg of Sophora japonica L., 9kg of Pueraria lobata, 9kg of Perilla frutescens , 6kg of Chrysanthemum indicumL., 9 kg of Folium Mori, 6 kg of Prunus mume, 9kg of tuckahoe, 9kg of Lilium lancifolium, mixing, soaking the material in 15 times of water for 30 minutes, heating and reflux extracting for 1 hour, filtering with 200 meshes, and reflux extracting the residue with 10 times of water for 1 hour; Mixing filtrates, concentrating under reduced pressure to a density of about 1.08, adding appropriate amount of maltodextrin, and spray drying to obtain extract; 0.3kg of folic acid, 0.5kg of chitosan oligosaccharide and 1.0kg of xylooligosaccharide are added, mixed evenly, put into a powder packaging machine, subpackaged, and made into a solid beverage as 1og/ bag. Embodiment 2: 100 patients with hyperuricemia are selected as health products to take the solid beverage prepared by the preparation method of the medicinal diet composition for preventing and treating hyperuricemia and gout 2-3 times a day; Take a bag of this product every time, add 100 - 200 ml of hot water, stir it until it dissolves, and then eat it. After two weeks of continuous administration, uric acid in more than 70% patients decreased in different degrees. The above is only a preferred embodiment of the present invention, and is not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.
Claims (6)
- THE CLAIMS DEFINING THE INVENTION ARE AS FOLLOWS: 1. Medicinal diet composition for preventing and treating hyperuricemia and gout and preparation method thereof is characterized in comprising the following components in parts by weight: 1-15 parts of Cichorium intybus L., 1-15 parts of Symphytum officinale L, 1-20 parts of Phyllanthus emblica, 1-15 parts of Sophora japonica L., 1-20 parts of Pueraria lobata, 1-15 parts of Perilla frutescens , 1-10 parts of Chrysanthemum indicum L., 1-15 parts of Folium Mori, 1-15 parts of Prunus mume, 1-20 parts of tuckahoe, 1-20 parts of Lilium lancifolium , 0.1-1 part of folic acid, 0.1-1.5 parts of chitosan oligosaccharide, 0.5-5 parts of xylooligosaccharide.
- 2. Medicinal diet composition for preventing and treating hyperuricemia and gout and preparation method thereof is characterized in that the medicated diet composition is prepared from the following raw materials in parts by weight: 8-10 parts of Cichorium intybus L., 5-7 parts of Symphytum officinale L, 8-10 parts of Phyllanthus emblica, 8-10 parts of Sophora japonica L., 8-10 parts of Pueraria lobata, 8-10 parts of Perilla frutescens , 5-7 parts of Chrysanthemum indicum L., 8-10 parts of Folium Mori, 5-7 parts of Prunus mume, 8-10 parts of tuckahoe, 8-10 parts of Lilium lancifolium , 0.2-0.4part of folic acid, 0.4-0.6 parts of chitosan oligosaccharide, 0.8-1.2 parts of xylooligosaccharide.
- 3. Medicinal diet composition for preventing and treating hyperuricemia and gout and preparation method thereof is characterized in that the medicated diet composition is prepared from the following raw materials in parts by weight: 9 parts of Cichorium intybus L., 6 parts of Symphytum officinale L, 9 parts of Phyllanthus emblica, 9 parts of Sophora japonica L., 9 parts of Pueraria lobata, 9 parts of Perilla frutescens , 6 parts of Chrysanthemum indicumL., 9 parts of Folium Mori, 6 parts of Prunus mume, 9 parts of tuckahoe, 9 parts of Lilium lancifolium , 0.3 part of folic acid, 0.5 parts of chitosan oligosaccharide,1 part of xylooligosaccharide.
- 4. Medicinal diet composition for preventing and treating hyperuricemia and gout and preparation method thereof is characterized in weighing raw materials according to the weight parts of the medicinal diet composition for preventing and treating hyperuricemia and gout according to any one of claims 1-3, mixing Cichorium intybus L., Symphytum officinale L, Phyllanthus emblica, Sophora japonica L., Pueraria lobata, Perilla frutescens, Chrysanthemum indicum L., Folium Mori, Prunus mume, poria cocos and Lilium lancifolium, soaking in 10-20 times of water for 15-60 minutes, heating, refluxing and extracting for 0.5-2 hours, Adding 10-20 times of water into the dregs, refluxing and extracting for 0.5-2 hours, and filtering with 80-200 meshes to obtain a second extracting solution; Mixing the first extracting solution and the second extracting solution, concentrating, and adding folic acid, chitosan oligosaccharide and xylooligosaccharide to obtain the medicated diet composition for preventing and treating hyperuricemia and gout.
- 5. The preparation method of the medicinal diet composition for preventing and treating hyperuricemia and gout, according to claim 4, is characterized in that Cichorium intybus L., Symphytum officinale L, Phyllanthus emblica, Sophora japonica L., Pueraria lobata, Perilla frutescens , Chrysanthemum indicum L., Folium Mori, Prunus mume, poria cocos and Lilium lancifolium are mixed and soaked in 12-15 times of water for -35 minutes.
- 6. The preparation method of the medicinal diet composition for preventing and treating hyperuricemia and gout, according to claim 4, is characterized in that 10-15 times of water by mass is added to the dregs.FIGURES 1/1Figure 1
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