AU2019382117A1 - Process for the preparation of (S)-nicotin from myosmine - Google Patents
Process for the preparation of (S)-nicotin from myosmineInfo
- Publication number
- AU2019382117A1 AU2019382117A1 AU2019382117A AU2019382117A AU2019382117A1 AU 2019382117 A1 AU2019382117 A1 AU 2019382117A1 AU 2019382117 A AU2019382117 A AU 2019382117A AU 2019382117 A AU2019382117 A AU 2019382117A AU 2019382117 A1 AU2019382117 A1 AU 2019382117A1
- Authority
- AU
- Australia
- Prior art keywords
- myosmine
- nicotin
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- DPNGWXJMIILTBS-UHFFFAOYSA-N Myosmine Chemical compound C1CCN=C1C1=CC=CN=C1 DPNGWXJMIILTBS-UHFFFAOYSA-N 0.000 title 2
- SNICXCGAKADSCV-JTQLQIEISA-N Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 title 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18206826.2A EP3653617B1 (en) | 2018-11-16 | 2018-11-16 | Process for the preparation of (s)-nicotin from myosmine |
| EP18206826.2 | 2018-11-16 | ||
| PCT/EP2019/056194 WO2020098978A1 (en) | 2018-11-16 | 2019-03-12 | Process for the preparation of (s)-nicotin from myosmine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2019382117A1 true AU2019382117A1 (en) | 2020-05-22 |
| AU2019382117B2 AU2019382117B2 (en) | 2021-05-27 |
Family
ID=64331961
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2019382117A Active AU2019382117B2 (en) | 2018-11-16 | 2019-03-12 | Process for the preparation of (S)-nicotin from myosmine |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP3653617B1 (en) |
| JP (1) | JP7068554B2 (en) |
| KR (1) | KR102393478B1 (en) |
| CN (1) | CN113272289A (en) |
| AU (1) | AU2019382117B2 (en) |
| BR (1) | BR112021009328B1 (en) |
| CA (1) | CA3118774C (en) |
| DK (1) | DK3653617T3 (en) |
| ES (1) | ES2836481T3 (en) |
| HR (1) | HRP20201895T1 (en) |
| HU (1) | HUE051799T2 (en) |
| MX (1) | MX2021005584A (en) |
| PL (1) | PL3653617T3 (en) |
| PT (1) | PT3653617T (en) |
| SI (1) | SI3653617T1 (en) |
| WO (1) | WO2020098978A1 (en) |
| ZA (1) | ZA202103223B (en) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113373188B (en) * | 2020-03-10 | 2024-02-20 | 重庆博腾制药科技股份有限公司 | Synthesis method of (S) -nicotine |
| CN112409327A (en) * | 2020-11-18 | 2021-02-26 | 山东金城医药化工有限公司 | Preparation method of high-optical-purity nicotine |
| US20220154231A1 (en) * | 2020-11-18 | 2022-05-19 | Shandong Jincheng Pharmaceutical Chemical Co., Ltd | Methods for preparing nicotine and intermediates thereof |
| CN112795603B (en) * | 2020-12-14 | 2022-06-24 | 山东金城医药化工有限公司 | Method for preparing (S) -2- (3-pyridine) -pyrrolidine |
| CN115404250A (en) * | 2021-05-29 | 2022-11-29 | 重庆博腾制药科技股份有限公司 | Method for preparing (S) -nicotine by reduction mode |
| CN115404249A (en) * | 2021-05-29 | 2022-11-29 | 重庆博腾制药科技股份有限公司 | Preparation method and application of (S) -nicotine intermediate |
| CN115491364A (en) | 2021-06-20 | 2022-12-20 | 陈泽聪 | Imine reductase mutant, imine reductase and glucose dehydrogenase coexpression enzyme and application thereof |
| CN115851635A (en) * | 2021-08-10 | 2023-03-28 | 深圳瑞德林生物技术有限公司 | Preparation method of S-nicotine |
| CN114195759B (en) * | 2021-08-26 | 2023-10-20 | 上海零诺生物科技有限公司 | Preparation method of 2-methyl-5- (1-methylpyrrolidine-2-yl) pyridine |
| CN113999084B (en) * | 2021-11-03 | 2024-04-16 | 成昌梅 | Synthesis and preparation method of (S) - (-) -nicotine |
| CN114437029A (en) * | 2022-01-24 | 2022-05-06 | 深圳市华加生物科技有限公司 | Preparation method for asymmetric synthesis of chiral nicotine and chiral nicotine |
| CN114807265A (en) * | 2022-03-31 | 2022-07-29 | 上海锐康生物技术研发有限公司 | Synthetic method of S-nicotine |
| CN114671852A (en) * | 2022-04-24 | 2022-06-28 | 仙居两山生物科技有限公司 | Preparation method of high-purity levo-nicotine medical intermediate |
| CN114702475B (en) * | 2022-05-17 | 2023-12-26 | 大连天源基化学有限公司 | Synthesis process of nicotine with single configuration |
| EP4332098A1 (en) | 2022-08-31 | 2024-03-06 | Siegfried AG | Chiral synthesis of nornicotine and nicotine |
| CN116218803B (en) * | 2023-01-31 | 2024-03-19 | 河北工业大学 | Imine reductase, preparation method thereof and DNA (deoxyribonucleic acid) encoding imine reductase |
| CN115820762B (en) | 2023-02-20 | 2023-05-16 | 山东金城医药化工有限公司 | Process for the synthesis of (S) -nicotine and intermediates thereof |
| CN116217544B (en) * | 2023-05-08 | 2023-08-29 | 济南悟通生物科技有限公司 | Synthesis method of (S) -nornicotine |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102617547B (en) | 2011-01-27 | 2016-02-10 | 上海特化医药科技有限公司 | A kind of method preparing racemic nicotine |
| US8378111B2 (en) | 2011-02-02 | 2013-02-19 | Divi's Laboratories, Ltd. | Process for the resolution of (R,S)-nicotine |
| US8367837B2 (en) * | 2011-02-14 | 2013-02-05 | Divi's Laboratories, Ltd. | Process for the preparation of (R,S)-nicotine |
| HUE036947T2 (en) | 2012-05-11 | 2018-08-28 | Codexis Inc | Engineered imine reductases and methods for the reductive amination of ketone and amine compounds |
| IL225900A0 (en) | 2013-04-22 | 2014-03-31 | Perrigo Api Ltd | A process for the preparation of nicotine comprising the enzymatic reduction of 4-(methylamino)-1-(pyridin-3-yl)butan-1-one |
| WO2015073555A1 (en) | 2013-11-13 | 2015-05-21 | Codexis, Inc. | Engineered imine reductases and methods for the reductive amination of ketone and amine compounds |
| CN113149958A (en) * | 2014-10-22 | 2021-07-23 | 下一代实验室有限责任公司 | Process for the preparation of (R, S) -nicotine |
-
2018
- 2018-11-16 SI SI201830153T patent/SI3653617T1/en unknown
- 2018-11-16 EP EP18206826.2A patent/EP3653617B1/en active Active
- 2018-11-16 DK DK18206826.2T patent/DK3653617T3/en active
- 2018-11-16 PL PL18206826T patent/PL3653617T3/en unknown
- 2018-11-16 PT PT182068262T patent/PT3653617T/en unknown
- 2018-11-16 ES ES18206826T patent/ES2836481T3/en active Active
- 2018-11-16 HU HUE18206826A patent/HUE051799T2/en unknown
-
2019
- 2019-03-12 BR BR112021009328-1A patent/BR112021009328B1/en active IP Right Grant
- 2019-03-12 CA CA3118774A patent/CA3118774C/en active Active
- 2019-03-12 MX MX2021005584A patent/MX2021005584A/en unknown
- 2019-03-12 CN CN201980058561.8A patent/CN113272289A/en active Pending
- 2019-03-12 AU AU2019382117A patent/AU2019382117B2/en active Active
- 2019-03-12 WO PCT/EP2019/056194 patent/WO2020098978A1/en active Application Filing
- 2019-03-12 JP JP2021526250A patent/JP7068554B2/en active Active
- 2019-03-12 KR KR1020217018020A patent/KR102393478B1/en active IP Right Review Request
-
2020
- 2020-11-27 HR HRP20201895TT patent/HRP20201895T1/en unknown
-
2021
- 2021-05-12 ZA ZA2021/03223A patent/ZA202103223B/en unknown
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