AU2019218187B2 - Dioxinoquinoline compounds, preparation method and uses thereof - Google Patents

Dioxinoquinoline compounds, preparation method and uses thereof Download PDF

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Publication number
AU2019218187B2
AU2019218187B2 AU2019218187A AU2019218187A AU2019218187B2 AU 2019218187 B2 AU2019218187 B2 AU 2019218187B2 AU 2019218187 A AU2019218187 A AU 2019218187A AU 2019218187 A AU2019218187 A AU 2019218187A AU 2019218187 B2 AU2019218187 B2 AU 2019218187B2
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alkyl
substituted
group
compound
pharmaceutically acceptable
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AU2019218187A1 (en
Inventor
Shouye FENG
Chenming Hu
Yansheng Liu
Yueming SUN
Zhongxiang WANG
Zhanqiang XU
Hailong Yang
Leifu YANG
Shannan YU
Hongbo Zhang
Qiang Zhang
Nanqiao ZHENG
Likai ZHOU
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Beijing Scitech MQ Pharmaceuticals Ltd
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Beijing Scitech MQ Pharmaceuticals Ltd
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Priority claimed from PCT/CN2018/076233 external-priority patent/WO2018153293A1/zh
Application filed by Beijing Scitech MQ Pharmaceuticals Ltd filed Critical Beijing Scitech MQ Pharmaceuticals Ltd
Priority claimed from PCT/CN2019/073260 external-priority patent/WO2019154133A1/zh
Publication of AU2019218187A1 publication Critical patent/AU2019218187A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AU2019218187A 2017-02-27 2019-01-25 Dioxinoquinoline compounds, preparation method and uses thereof Active AU2019218187B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
CN201710107756 2017-02-27
CN201710161873.4A CN108503650B (zh) 2017-02-27 2017-03-17 二噁烷并喹唑啉类化合物或其药用盐或其水合物及其作为酪氨酸激酶抑制剂的应用
PCT/CN2018/076233 WO2018153293A1 (zh) 2017-02-27 2018-02-11 二噁烷并喹唑啉与二噁烷并喹啉类化合物及其制备方法与应用
AUPCT/CN2018/076233 2018-02-11
CN201810983341.3 2018-08-27
CN201810983341.3A CN110156803A (zh) 2017-02-27 2018-08-27 二噁烷并喹啉类化合物及其制备方法与应用
PCT/CN2019/073260 WO2019154133A1 (zh) 2018-02-11 2019-01-25 二噁烷并喹啉类化合物及其制备方法与应用

Publications (2)

Publication Number Publication Date
AU2019218187A1 AU2019218187A1 (en) 2020-09-10
AU2019218187B2 true AU2019218187B2 (en) 2021-10-14

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AU2019218187A Active AU2019218187B2 (en) 2017-02-27 2019-01-25 Dioxinoquinoline compounds, preparation method and uses thereof

Country Status (5)

Country Link
CN (3) CN108503650B (zh)
AU (1) AU2019218187B2 (zh)
DK (1) DK3750893T3 (zh)
ES (1) ES2945573T3 (zh)
SG (1) SG11202007554TA (zh)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019079759A1 (en) 2017-10-19 2019-04-25 Laurence Rahme ANTI-PERSISTENCE AND ANTI-VIRULENCE COMPOUNDS WITH BROAD SPECTRUM
CN110156804B (zh) * 2018-02-11 2021-01-12 北京赛特明强医药科技有限公司 一种二噁烷并喹啉类化合物及其制备方法
CN111196814B (zh) * 2018-11-19 2022-12-06 北京赛特明强医药科技有限公司 芳环连二噁烷并喹唑啉或喹啉类化合物、组合物及其应用
CN111004257B (zh) * 2019-12-24 2021-06-29 武汉九州钰民医药科技有限公司 制备RET抑制剂Selpercatinib的方法
CN112939995A (zh) * 2021-02-02 2021-06-11 北京工业大学 二噁烷并喹唑啉衍生物制备方法
CN114957136A (zh) * 2021-02-24 2022-08-30 南京科默生物医药有限公司 一种用作vegfr抑制剂的抗肿瘤化合物及其用途
WO2024094016A1 (zh) * 2022-11-01 2024-05-10 北京赛特明强医药科技有限公司 一种二噁烷并喹啉类化合物的盐、其晶型以及它们的制备方法及应用

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005030140A2 (en) * 2003-09-26 2005-04-07 Exelixis, Inc. C-met modulators and methods of use
CN103328447A (zh) * 2010-09-12 2013-09-25 南京爱德程医药科技有限公司 作为c-Met激酶抑制剂的化合物
CN103402505A (zh) * 2010-09-27 2013-11-20 埃克塞里艾克西斯公司 用于治疗去势抵抗性***癌和成骨性骨转移的met和vegf的双重抑制剂
CN104530063A (zh) * 2015-01-13 2015-04-22 北京达立泰制药科技有限公司 喹唑啉并杂环类化合物及其制备方法和作为用于治疗癌症的表皮生长因子受体抑制剂的应用
CN105541798A (zh) * 2016-02-03 2016-05-04 中国人民解放军第二军医大学 具有抗肿瘤活性的喹啉类多靶点激酶抑制剂及其制备方法
CN105837586A (zh) * 2015-12-14 2016-08-10 北京赛特明强医药科技有限公司 二噁烷并喹唑啉胺类化合物及其制备方法和作为表皮生长因子受体抑制剂的应用
CN106279147A (zh) * 2015-05-21 2017-01-04 中国科学院上海药物研究所 一种吡啶并氮杂环化合物及其制备方法和用途
WO2018153293A1 (zh) * 2017-02-27 2018-08-30 北京赛特明强医药科技有限公司 二噁烷并喹唑啉与二噁烷并喹啉类化合物及其制备方法与应用

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005030140A2 (en) * 2003-09-26 2005-04-07 Exelixis, Inc. C-met modulators and methods of use
CN103328447A (zh) * 2010-09-12 2013-09-25 南京爱德程医药科技有限公司 作为c-Met激酶抑制剂的化合物
CN103402505A (zh) * 2010-09-27 2013-11-20 埃克塞里艾克西斯公司 用于治疗去势抵抗性***癌和成骨性骨转移的met和vegf的双重抑制剂
CN104530063A (zh) * 2015-01-13 2015-04-22 北京达立泰制药科技有限公司 喹唑啉并杂环类化合物及其制备方法和作为用于治疗癌症的表皮生长因子受体抑制剂的应用
CN106279147A (zh) * 2015-05-21 2017-01-04 中国科学院上海药物研究所 一种吡啶并氮杂环化合物及其制备方法和用途
CN105837586A (zh) * 2015-12-14 2016-08-10 北京赛特明强医药科技有限公司 二噁烷并喹唑啉胺类化合物及其制备方法和作为表皮生长因子受体抑制剂的应用
CN105541798A (zh) * 2016-02-03 2016-05-04 中国人民解放军第二军医大学 具有抗肿瘤活性的喹啉类多靶点激酶抑制剂及其制备方法
WO2018153293A1 (zh) * 2017-02-27 2018-08-30 北京赛特明强医药科技有限公司 二噁烷并喹唑啉与二噁烷并喹啉类化合物及其制备方法与应用

Also Published As

Publication number Publication date
ES2945573T3 (es) 2023-07-04
CN111788207A (zh) 2020-10-16
SG11202007554TA (en) 2020-09-29
CN108503650A (zh) 2018-09-07
CN108503650B (zh) 2021-02-12
DK3750893T3 (da) 2023-05-08
CN111788207B (zh) 2021-03-23
CN110156803A (zh) 2019-08-23
AU2019218187A1 (en) 2020-09-10

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DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE INVENTION TITLE TO READ DIOXINOQUINOLINE COMPOUNDS, PREPARATION METHOD AND USES THEREOF