AU2018100737A4 - Dietary Fiber Tablet With Weight-Reducing Effect and Preparation Method Thereof - Google Patents

Abstract

The invention discloses a dietary fiber tablet with a weight-reducing effect and the preparation method thereof. The dietary fiber tablet comprises soluble dietary fiber, insoluble dietary fiber, food additives and auxiliary materials. The dietary fiber tablet 5 with weight-reducing effect and the preparation method thereof are formed by combining different types of soluble dietary fiber with insoluble dietary fiber. And the weight-reducing effect is obviously stronger than that of using only one dietary fiber. The effect of using only one dietary fiber is not ideal, and the invention overcomes the disadvantage of large dose in using only one dietary fiber. 205 - Weight/Kg o5 GrouI Group2 IGroup3 IGroup4 IGroup5 IGroup6 IGroup7 Group 1Weight Decrease/Kg ct 10 Time/Week

Description

DIETARY FIBER TABLET WITH WEIGHT-REDUCING EFFECT AND PREPARATION METHOD THEREOF

TECHNICAL FIELD

[0001] The invention relates to the technical field of health products, particularly to a dietary fiber tablet having a weight-reducing effect and a preparation method thereof.

BACKGROUND ART

[0002] Obesity is a chronic nutritional disease caused by the loss of balance in energy metabolism in the body. With the improvement of human living standards, lifestyle changes, changes in dietary patterns and changes in the living environment, obesity has become a major killer of human health. As early as in 1997, the World Health Organization (WHO) proposed that obesity is a pandemic and has seriously affected human health. Studies have shown that obesity can be caused by a variety of factors including genetics, environment, dietary structure, lifestyle and metabolism. It is the susceptible factors of atherosclerosis (AS), type II diabetes, cardiovascular disease, tumor, non-alcoholic fatty liver disease (NAFLD), sleep disorders, osteoarthritis and other diseases. In addition, obesity is an important component of metabolic syndrome (MS) and constitutes the pathophysiological basis of metabolic syndrome. The damage to the cardiovascular system caused by obesity is particularly noticeable. Every 1% increase in the body mass index (BMI) increases the prevalence of hypertension by 16%, and increases the risk of coronary heart disease in men and women by 3.6% and 3.3%; Obesity also causes a decrease in cardiac contractility and a negative effect on heart function; Mild obesity can lead to myocardial remodeling, left ventricular hypertrophy, and structural changes and dysfunction of the peripheral blood vessels. According to WHO statistics, at least 2.8 million adults die of overweight or obesity each year, 23% of ischemic heart disease, 44% of diabetes and 7%-41% of cancers are attributable to overweight and obesity.

[0003] In recent years, the incidence of obesity has increased year by year, and it has become widespread all over the world, becoming a serious threat to human health. With the development of China’s economic level, the improvement of people’s living standards, changes in lifestyle, changes in dietary patterns and changes in the living environment, various problems caused by obesity have become increasingly prominent, bringing many problems to people’s lives. Therefore, effective prevention and reduction of obesity has become a very urgent medical issue and has important practical significance.

[0004] However, there are many disadvantages and shortcomings in the weight-reducing drugs or health foods on the market. For example, "Orlistat" and "Sibutramine" and other foreign-produced weight-reducing drugs have characteristics of large side effects and drug-withdrawal rebound. Some domestic health foods for weight loss and some Chinese medicines for weight loss do not have a clear mechanism for weight loss, always with many safety issues; and the safety of domestic chemical weight loss pills is also worrying. Events such as the NOMATYNE Incident and the YUZHITANG Incident, arising out of the toxic side effect of chemical synthesis weight-loss drugs, have been exposed one after another, leaving a very bad influence on the reliability of the weight-loss products in the hearts of the general public.

[0005] Therefore, how to solve the obesity problem safely and effectively is a challenge that we face today, and it is also a subject of great market value.

SUMMARY

[0006] In order to solve the problems of the prior art, the embodiments of the present invention provide a dietary fiber tablet having a weight-reducing effect and a preparation method thereof. The technical scheme is as follows: [0007] On the one hand, a dietary fiber tablet with a weight-reducing effect includes: soluble dietary fiber, insoluble dietary fiber, food additives and auxiliary materials.

[0008] Further, the soluble dietary fiber includes: fructo oligosaccharide, konjac flour, and sodium alginate.

[0009] Further, the insoluble dietary fiber includes chitosan and oatmeal.

[0010] Further, the food additives include capsorubin.

[0011] Further, the auxiliary materials include magnesium stearate and micro powder silica gel.

[0012] Further, by mass percentage, it includes: 60% to 94% of soluble dietary fiber and 39% to 5% of insoluble dietary fiber.

[0013] Further, include: fructo oligosaccharide 1-6 parts, konjac flour 1-4 parts, sodium alginate 0.5-2 parts, oat or chitosan 0.5-4 parts, and capsorubin 0.03-0.09 parts.

[0014] On the other hand, a method for preparing a dietary fiber tablet having a weight-reducing effect includes the following steps: taking soluble dietary fiber, insoluble dietary fiber, food additives and auxiliary materials, mixing them evenly in proportion, and directly compressing the tablets.

[0015] Further, the soluble dietary fiber includes: fructo oligosaccharide, konjac flour and sodium alginate; the insoluble dietary fiber includes chitosan and oatmeal; the food additive includes capsorubin; and the auxiliary materials include magnesium stearate and micro powder silica gel.

[0016] Further, fructo oligosaccharide 1-6 parts, konjac flour 1-4 parts, sodium alginate 0.5-2 parts, oat or chitosan 0.5-4 parts, and capsorubin 0.03-0.09 parts.

[0017] The beneficial effects brought by the technical solution provided by the embodiments of the present invention are: the dietary fiber tablet with weight-reducing effect and the preparation method thereof are formed by combining different types of soluble dietary fiber and insoluble dietary fiber, and the weight-reducing effect is better than that of using only one type of dietary fiber, overcoming the disadvantages of unsatisfactory weight loss and large doses when only using a single type of dietary fiber.

DESCRIPTION OF DRAWINGS

[0018] In order to more clearly explain the technical solutions in the embodiments of the present invention, the drawings used in the description of the embodiments will be briefly described below. It is obvious that the drawings in the following description are merely some new embodiments of the present invention. For those of ordinary technical personnel in the art, other drawings may also be obtained on the basis of these drawings without any creative work.

[0019] FIG. 1 is a diagram showing a decrease in rat body weight of different formula ratios in Embodiment 1 of the present invention; [0020] FIG. 2 is a diagram showing the result of body weight reduction by trail of eating in Embodiment 3 of the present invention.

DETAILED DESCRIPTION OF EMBODIMENTS

[0021] To make the objectives, technical solutions and advantages of the present invention clearer, the following further describes the embodiments of the present invention in detail with the reference of the accompanying drawings.

[0022] Embodiment 1 [0023] For the combination of different types of dietary fiber, the optimal dietary fiber combination is determined by observing the weight loss effect in animal experiments.

[0024] 100 male Wistar rats weighing 80±5g were provided by the Experimental Animal Center of Jilin University. After one week of fitness observation, their bodies were weighed. They were randomly divided into 10 groups: normal control group, high-fat modeling group, dietary fiber group 1 (0.5 parts of sodium alginate, 5.45 parts of fructo oligosaccharide, 3.5 parts of konjac flour, 0.5 parts of chitosan and 0.05 parts of capsorubin), dietary fiber group 2 (sodium alginate 0.5 parts, fructo oligosaccharide 4 parts, konjac flour 3.45 parts, chitosan 2 parts, capsorubin 0.05 parts), dietary fiber group 3 (sodium alginate 1.5 parts, fructo oligosaccharide 2.5 parts, konjac flour 3 parts, chitosan 3 parts, capsorubin 0.05 parts), dietary fiber group 4 (sodium alginate 0.5 parts, fructo oligosaccharide 3 parts, konjac flour 2.45 parts, chitosan 4 parts, capsorubin 0.05 parts), fructo oligosaccharide group, konjac flour group, sodium alginate group, and chitosan group. In each group there are 10 rats. Except for the normal control group, other groups were fed with lard with a high content of saturated fatty acids, as well as cholesterol and bile salts to cause a hyperlipidemia model. After 8 weeks of feeding, body weight was taken as the index of observation. Experimental data were statistically processed, and Student’s test was used for the significance test. The results are shown in Table 1.

[0025] Table 1 Changes in body weight of rats after 8 weeks of feeding

[0026] Note: Group 1 is the normal control group; Group 2 is the high-fat modeling group; Group 3 is the sodium alginate group; Group 4 is the fructo oligosaccharide group; Group 5 is the konjac flour group; Group 6 is the chitosan group; Group 7 is the optimal dietary fiber group (dietary fiber group 4).

[0027] The experimental results showed that the average body weight of the high-fat modeling group was 185.6±12.3g, while the average body weight of the optimal dietary fiber group (dietary fiber group 4) was 151.3±10.9g. The Student’s test showed that the difference between the two groups was extremely significant (p<0.01), indicating that the dietary fiber group has a good effect of reducing body weight in rats. As shown in Figure 1, the experimental results also show that the dietary fiber group is superior to the single use of a dietary fiber.

[0028] Embodiment 2 [0029] Preparation of a dietary fiber combination was studied and the dosage form was tablet. The tablets were prepared through full powder tableting and granule tableting respectively.

[0030] (1) Full powder tableting [0031] In proportion, 0.5 parts of sodium alginate, 4 parts of fructo oligosaccharide, 3.45 parts of konjac flour, 2 parts of chitosan, and 0.05 parts of capsorubin were weighed. After the above substances were mixed uniformly, magnesium stearate was added as a lubricant and compress directly. According to the general rules for preparations of Chinese Pharmacopoeia 2015, the quality inspection results show that the tablet weight of tablets prepared by the full powder tableting process exceeds the limit (20 samples are randomly selected, each tablet and all are accurately weighed, and the difference in tablet weight is calculated; when the average tablet weight is 0.30g or more, the weight difference limit is ±5%), which is related to the poor flowability of raw materials such as konjac flour.

[0032] (2) Granule tableting is divided into two categories of processes, wet granule tableting and dry granule tableting: [0033] (a) Wet granulation [0034] 0.5 part of sodium alginate, 4 parts of fructo oligosaccharide, 3.45 parts of konjac flour, 2 parts of chitosan and 0.05 parts of capsorubin were weighed in proportion. The above substances were uniformly mixed, and wet granulation was performed. Magnesium stearate was added as a lubricant and the tablets were formed by compression.

[0035] (b) Dry granulation [0036] Weigh proportions of sodium alginate 5%, fructo oligosaccharide 40%, konjac flour 35%, chitosan 20%, and then add the food additive capsorubin pigment. Mix the above materials and perform dry granulation. Add magnesium stearate as a lubricant and compress.

[0037] (3) Tablet quality testing with different preparation processes [0038] Appearance measurement: Randomly select 20 samples and calculate the average score according to the following method: 4 points for completeness and smoothness, uniform color and without color spots; 2 points for completeness and smoothness, uniform color, but with color spots; 1 point for completeness and smoothness, but uneven color; 0 for not being complete or smooth.

[0039] Hardness measurement: Randomly take 10 samples. Determine the radial pressure of each piece with a hardness tester and calculate the average value.

[0040] Friability measurement: Randomly take 20 samples, weigh accurately, place on the friability instrument for collision testing of 4 min, take out and weigh accurately, and calculate the weight loss percentage of the samples. Repeated measurements are performed 6 times to calculate the average value.

[0041] Disintegration time limit (s): 6 samples are taken at random, placed on a disintegration time analyzer and the disintegration time of the drug was determined at 37°C, and disintegration should be completed within 15 minutes.

[0042] Table 2 Dietary fiber tablets quality test results of 3 kinds of preparation process

[0043] As a result, both tablet preparation processes can meet the quality requirements of the general rules for preparations of Chinese Pharmacopoeia 2015, in terms of differences in tablet weight, hardness, friability, and so on.

[0044] Embodiment 3 [0045] 30 volunteers were given 12 weeks of oral administration and the body weights, before and after the trial, were compared.

[0046] Table 2 Volunteer weight change after 12 weeks of oral administration

[0047] As shown in Table 2 and FIG. 2, the body weight of 30 volunteers who took the dietary fiber combination tablet of the present invention (sodium alginate 0.5 parts, fructo oligosaccharide 3 parts, konjac flour 2.45 parts, chitosan 4 parts, capsorubin 0.05 parts) was reduced by 12.1±2.9Kg after 12 weeks, indicating that the present invention has a better weight loss effect. Volunteers did not suffer excitement, insomnia, anorexia, constipation, and other undesirable symptoms during use, indicating that the product is of good safety.

[0048] From the above test, it can be concluded that the combination of different types of soluble dietary fiber and insoluble dietary fiber significantly enhances the weight loss effect compared with using only one kind of dietary fiber. The present invention overcomes the disadvantages of unsatisfactory weight loss and dose of using one kind of dietary fiber.

[0049] The sequence numbers of the foregoing embodiments of the present invention are merely for description and do not represent the advantages and disadvantages of the embodiments.

[0050] The foregoing descriptions are merely preferred embodiments of the present invention, and are not intended to limit the present invention. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention shall be included in the protection of the present invention.

Claims (10)

1. A dietary fiber tablet having a weight-reducing effect, characterized by comprising: soluble dietary fiber, insoluble dietary fiber, food additives and auxiliary materials.

2. The dietary fiber tablet according to claim 1, wherein the soluble dietary fiber comprises fructo oligosaccharide, konjac flour, and sodium alginate.

3. The dietary fiber tablet according to claim 2, wherein the insoluble dietary fiber comprises chitosan and oatmeal.

4. The dietary fiber tablet according to claim 3, wherein the food additives comprises capsorubin.

5. The dietary fiber tablet according to claim 4, wherein the auxiliary materials comprises magnesium stearate and micro powder silica gel.

6. The dietary fiber tablet according to claim 5, by mass percentage, which comprises: 60% to 94% of soluble dietary fiber and 39% to 5% of insoluble dietary fiber.

7. The dietary fiber tablet according to claim 6, which comprises 1-6 parts of fructo oligosaccharide, 1-4 parts of konjac flour, 0.5-2 parts of sodium alginate, 0.5-4 parts of oats or chitosan, and 0.03-0.09 parts of capsorubin.

8. A method for preparing a dietary fiber tablet having a weight-reducing effect is characterized by comprising the following steps: taking soluble dietary fiber, insoluble dietary fiber, food additives and auxiliary materials, mixing them evenly, and directly compressing the tablets.

9. The method for preparing a dietary fiber tablet according to claim 8, wherein the soluble dietary fiber comprises fructo oligosaccharide, konjac flour and sodium alginate; the insoluble dietary fiber includes chitosan and oatmeal; the additives include capsorubin; the auxiliary materials include magnesium stearate and micro powder silica gel.

10. The method for preparing a dietary fiber tablet according to claim 9, wherein 1-6 parts of oligosaccharides, 1-4 parts of konjac flour, 0.5-2 parts of sodium alginate, 0.5-4 parts of oats or chitosan, and 0.03-0.09 parts of capsorubin and 0.03-0.09 parts of capsorubin.