AU2016229966A8 - Beta-D-2'-deoxy-2'alpha-fluoro-2'-beta-C-substituted-2-modified-N6-substituted purine nucleotides for HCV treatment - Google Patents

Beta-D-2'-deoxy-2'alpha-fluoro-2'-beta-C-substituted-2-modified-N6-substituted purine nucleotides for HCV treatment

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Publication number
AU2016229966A8
AU2016229966A8 AU2016229966A AU2016229966A AU2016229966A8 AU 2016229966 A8 AU2016229966 A8 AU 2016229966A8 AU 2016229966 A AU2016229966 A AU 2016229966A AU 2016229966 A AU2016229966 A AU 2016229966A AU 2016229966 A8 AU2016229966 A8 AU 2016229966A8
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AU
Australia
Prior art keywords
beta
substituted
deoxy
fluoro
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU2016229966A
Other versions
AU2016229966B2 (en
AU2016229966A1 (en
Inventor
Adel Moussa
Jean-Pierre Sommadossi
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Atea Pharmaceuticals Inc
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Atea Pharmaceuticals Inc
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Publication of AU2016229966A1 publication Critical patent/AU2016229966A1/en
Publication of AU2016229966A8 publication Critical patent/AU2016229966A8/en
Application granted granted Critical
Publication of AU2016229966B2 publication Critical patent/AU2016229966B2/en
Priority to AU2018282469A priority Critical patent/AU2018282469B2/en
Priority to AU2020203055A priority patent/AU2020203055B2/en
Priority to AU2021204022A priority patent/AU2021204022B2/en
Priority to AU2023202634A priority patent/AU2023202634A1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

A compound of the structure (A), or a pharmaceutically acceptable salt or composition thereof for the treatment of a host infected with or exposed to an HCV virus or other disorders more fully described herein.
AU2016229966A 2015-03-06 2016-03-07 Beta-D-2'-deoxy-2'alpha-fluoro-2'-beta-C-substituted-2-modified-N6-substituted purine nucleotides for HCV treatment Active AU2016229966B2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2018282469A AU2018282469B2 (en) 2015-03-06 2018-12-21 Beta-D-2'-deoxy-2'alpha-fluoro-2'-beta-C-substituted-2-modified-N6-substituted purine nucleotides for HCV treatment
AU2020203055A AU2020203055B2 (en) 2015-03-06 2020-05-08 Beta-D-2'-deoxy-2'alpha-fluoro-2'-beta-C-substituted-2-modified-N6-substituted purine nucleotides for HCV treatment
AU2021204022A AU2021204022B2 (en) 2015-03-06 2021-06-17 Beta-D-2'-deoxy-2'alpha-fluoro-2'-beta-C-substituted-2-modified-N6-substituted purine nucleotides for HCV treatment
AU2023202634A AU2023202634A1 (en) 2015-03-06 2023-04-28 Beta-D-2'-deoxy-2'alpha-fluoro-2'-beta-C-substituted-2-modified-N6-substituted purine nucleotides for HCV treatment

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201562129319P 2015-03-06 2015-03-06
US62/129,319 2015-03-06
US201562253958P 2015-11-11 2015-11-11
US62/253,958 2015-11-11
US201662276597P 2016-01-08 2016-01-08
US62/276,597 2016-01-08
PCT/US2016/021276 WO2016144918A1 (en) 2015-03-06 2016-03-07 β-D-2'-DEOXY-2'α-FLUORO-2'-β-C-SUBSTITUTED-2-MODIFIED-N6-SUBSTITUTED PURINE NUCLEOTIDES FOR HCV TREATMENT

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2018282469A Division AU2018282469B2 (en) 2015-03-06 2018-12-21 Beta-D-2'-deoxy-2'alpha-fluoro-2'-beta-C-substituted-2-modified-N6-substituted purine nucleotides for HCV treatment

Publications (3)

Publication Number Publication Date
AU2016229966A1 AU2016229966A1 (en) 2017-09-14
AU2016229966A8 true AU2016229966A8 (en) 2017-10-12
AU2016229966B2 AU2016229966B2 (en) 2018-09-27

Family

ID=56850466

Family Applications (5)

Application Number Title Priority Date Filing Date
AU2016229966A Active AU2016229966B2 (en) 2015-03-06 2016-03-07 Beta-D-2'-deoxy-2'alpha-fluoro-2'-beta-C-substituted-2-modified-N6-substituted purine nucleotides for HCV treatment
AU2018282469A Active AU2018282469B2 (en) 2015-03-06 2018-12-21 Beta-D-2'-deoxy-2'alpha-fluoro-2'-beta-C-substituted-2-modified-N6-substituted purine nucleotides for HCV treatment
AU2020203055A Active AU2020203055B2 (en) 2015-03-06 2020-05-08 Beta-D-2'-deoxy-2'alpha-fluoro-2'-beta-C-substituted-2-modified-N6-substituted purine nucleotides for HCV treatment
AU2021204022A Active AU2021204022B2 (en) 2015-03-06 2021-06-17 Beta-D-2'-deoxy-2'alpha-fluoro-2'-beta-C-substituted-2-modified-N6-substituted purine nucleotides for HCV treatment
AU2023202634A Pending AU2023202634A1 (en) 2015-03-06 2023-04-28 Beta-D-2'-deoxy-2'alpha-fluoro-2'-beta-C-substituted-2-modified-N6-substituted purine nucleotides for HCV treatment

Family Applications After (4)

Application Number Title Priority Date Filing Date
AU2018282469A Active AU2018282469B2 (en) 2015-03-06 2018-12-21 Beta-D-2'-deoxy-2'alpha-fluoro-2'-beta-C-substituted-2-modified-N6-substituted purine nucleotides for HCV treatment
AU2020203055A Active AU2020203055B2 (en) 2015-03-06 2020-05-08 Beta-D-2'-deoxy-2'alpha-fluoro-2'-beta-C-substituted-2-modified-N6-substituted purine nucleotides for HCV treatment
AU2021204022A Active AU2021204022B2 (en) 2015-03-06 2021-06-17 Beta-D-2'-deoxy-2'alpha-fluoro-2'-beta-C-substituted-2-modified-N6-substituted purine nucleotides for HCV treatment
AU2023202634A Pending AU2023202634A1 (en) 2015-03-06 2023-04-28 Beta-D-2'-deoxy-2'alpha-fluoro-2'-beta-C-substituted-2-modified-N6-substituted purine nucleotides for HCV treatment

Country Status (21)

Country Link
US (11) US9828410B2 (en)
EP (1) EP3265102A4 (en)
JP (3) JP6776273B2 (en)
KR (2) KR102363946B1 (en)
CN (2) CN107427530B (en)
AU (5) AU2016229966B2 (en)
CA (2) CA3182565A1 (en)
CO (1) CO2017010162A2 (en)
EA (1) EA037098B1 (en)
GE (3) GEP20217282B (en)
HK (1) HK1247829A1 (en)
IL (3) IL302877A (en)
MX (2) MX2017011386A (en)
MY (1) MY190867A (en)
PH (1) PH12017501598A1 (en)
RU (1) RU2764767C2 (en)
SA (1) SA517382236B1 (en)
SG (1) SG11201706841PA (en)
UA (1) UA124966C2 (en)
WO (1) WO2016144918A1 (en)
ZA (1) ZA201705852B (en)

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US10202412B2 (en) 2016-07-08 2019-02-12 Atea Pharmaceuticals, Inc. β-D-2′-deoxy-2′-substituted-4′-substituted-2-substituted-N6-substituted-6-aminopurinenucleotides for the treatment of paramyxovirus and orthomyxovirus infections
TW201811339A (en) * 2016-08-12 2018-04-01 美商艾洛斯生物製藥公司 Substituted nucleosides, nucleotides and analogs thereof
DK3512863T3 (en) 2016-09-07 2022-03-07 Atea Pharmaceuticals Inc 2β-substituted-N6-substituted purine nucleotides for the treatment of RNA virus
CN106432327A (en) * 2016-09-14 2017-02-22 江苏福瑞生物医药有限公司 Method for preparing sofosbuvir key intermediate
KR102592899B1 (en) * 2017-02-01 2023-10-24 아테아 파마슈티컬즈, 인크. Nucleotide hemi-sulfate salt for the treatment of hepatitis c virus
JP2021521118A (en) * 2018-04-10 2021-08-26 アテア ファーマシューティカルズ， インコーポレイテッド Treatment of HCV-infected patients with cirrhosis
US10874687B1 (en) 2020-02-27 2020-12-29 Atea Pharmaceuticals, Inc. Highly active compounds against COVID-19
WO2021173713A1 (en) 2020-02-27 2021-09-02 Atea Pharmaceuticals, Inc. Highly active compounds against covid-19
AU2021327241A1 (en) * 2020-08-19 2023-04-20 Atea Pharmaceuticals, Inc. Stereoselective manufacture of selected purine phosphoramidates
CN112961198B (en) * 2021-02-24 2022-03-25 南京欧信医药技术有限公司 Preparation method of purine nucleotide intermediate
TW202348228A (en) 2022-02-24 2023-12-16 德商艾斯巴赫生物有限公司 Viral combination therapy

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