AU2013204031A1 - c-Met modulators and methods of use - Google Patents

Abstract

C:lNRPonIbimCOJAMUII7f42_l.DOC-2627/2 0 The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed 5 cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate and/or modulate kinase receptor, particularly c-Met, KDR, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. 10 The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.

Description

H:\scg\imenvovcinNRPcrtbl\DCCISCGaIGd871179_ .doc- l Ml12013 c-Met Modulators and Method of Use This application is a divisional application derived from Australian Patent Application No. 2010204461 which is a divisional of Australian Patent Application No. 2004275842, the entire contents of which, as originally filed, are incorporated herein by reference. 5 CROSS-REFERENCE TO RELATED APPLICATIONS [0001] This application claims priority to U. S. provisional patent applications 60/506, 181 filed on September 26,2003, entitled"c-Met Modulators and Method of Use,"naming Bannen, Lynne et. al as inventors, 60/535, 377 filed on January 9, 2004, entitled"c-Met Modulators and 10 Method of Use,"naming Bannen, Lynne et. al as inventors and 60/577, 384 filed on June 4,2004, entitled"Synthesis of Quinoline and Quinazoline Kinase Modulators,"naming Bannen, Lynne et. al as inventors; each of which is hereby incorporated by reference in its entirety for all purposes. 15 FIELD OF THE INVENTION [0002] This invention relates to compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Even more specifically, the invention relates to quinazolines and quinolines which inhibit, regulate and/or modulate kinase receptor signal transduction 20 pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, methods of using them to treat kinase-dependent diseases and conditions, synthesis of the compounds as well as processes for formulating the compounds for pharmaceutical purposes. 25 BACKGROUND OF THE INVENTION [0003] Improvements in the specificity of agents used to treat cancer is of considerable interest because of the therapeutic benefits which would be realized if the side effects associated with the administration of these agents could be reduced. Traditionally, dramatic improvements in the treatment of cancer are associated with identification of therapeutic agents acting through 30 novel mechanisms. [0004] Protein kinases are enzymes that catalyze the phosphorylation of proteins, in particular, hydroxy groups on tyrosine, serine and threonine residues of proteins. The consequences of this seemingly simple activity are staggering; cell differentiation and proliferation; i. e. virtually all aspects of cell life in one-way or another depend on protein kinase activity. 35 Furthermore, abnormal protein kinase activity has been related to a host of WO 20051030140 PCT/US2004/031523 disorders, ranging from relatively non-life threatening diseases such as psoriasis to extremely virulent diseases such as glioblastoma (brain cancer). [0005] Protein kinases can be categorized as receptor type or non-receptor type. Receptor type tyrosine kinases have an extracellular, a transmembrane, and an intracellular portion, while non-receptor type tyrosine kinases are wholly intracellular. [0006] Receptor-type tyrosine kinases are comprised of a large number of transmembrane receptors with diverse biological activity. In fact, about 20 different subfamilies of receptor-type tyrosine kinases have been identified. One tyrosine kinase subfamily, designated the HER subfamily, is comprised of BGF (HER 1), ER2, HER3, and HBER4. Ligands of this subfamily of receptors identified so far include epithelial growth factor, TOP-alpha, amphiregulin, HB-EGF, betacellulin and heregulin. Another subfamily of these receptor-type tyrosine kinases is the insulin subfamily, which includes INS-R, IGF IR, and IR-R. The PDGF subfamily includes the PDGF-alpha and beta receptors, CSFIR, c-Kit and FLK-il. Then there is the FLK family, which is comprised of the kinase insert domain receptor (KDR), fetal liver kinase-1 (FLK-1), fetal liver kinase-4 (FLK-4) and the . fms-like tyrosine kinase-1 (fit-1). The PDOF and FLK families are usually considered together due to the similarities of the two groups. For a detailed discussion of the receptor .type tyrosine kinases, see Plowman et al., DN&P 7(6): 334-339, 1994, which is hereby incorporated by reference. [0007] The non-receptor type of tyrosine kinases is also comprised of numerous subfamilies, including Src, Frk, Btk, Csk, Abl, Zap7O, Fes/Fps, Fak, Jak, Ack, and LIMK. Each of these subfamilies is further sub-divided into varying receptors. For example, the Src subfamily is one of the largest and includes Src, Yes, Fyn, Lyn, Lek, Blk, Hck, Fgr, and Yrk. The Src subfamily of enzymes has been linked to oncogenesis. For a more detailed discussion of the non-receptor type of tyrosine kinases, see Bolen, Oncogene, 8:2025-2031 (1993), which is hereby incorporated by reference. [0008] Since protein kinases and their ligands play critical roles in various cellular activities, deregulation of protein kinase enzymatic activity can lead to altered cellular properties, such as uncontrolled cell growth associated with cancer. In addition 'to oncological indications, altered kinase signaling is implicated in numerous other pathological diseases. These include, but are not limited to: immunological disorders, cardiovascular diseases, inflammatory diseases, and degenerative diseases. Therefore, 2 WO 2005/030140 PCT/US2004/031523 both receptor and non-receptor protein kinases are attractive targets for small molecule drug discovery. [0009] One particularly attractive goal for therapeutic use of kinase modulation relates to oncological indications. For example, modulation of protein kinase activity for the treatment of cancer has been demonstrated successfully with the FDA approval of Gleevec@ (imatinib mesylate, produced by Novartis Pharmaceutical Corporation of East Hanover, NJ) for the treatment of Chronic Myeloid Leukemia (CML) and gastrointestinal stroma cancers (GIST). Gleevec is a c-Kit and Abi kinase inhibitor. [0010] Modulation (particularly inhibition) of cell proliferation and angiogenesis, two key cellular processes needed for tumor growth and survival (Matter A. Drug Disc Technol 2001 6, 1005-1024), is an attractive goal for development of small-iolecule drugs. Anti angiogenic therapy represents a potentially important approach for the treatment of solid tumors and other diseases associated with dysregulated vascularization, including ischemic coronary artery disease, diabetic retinopathy, psoriasis and rheumatoid arthritis. As well, cell antiproliferative agents are desirable to slow or stop the growth of tumors. [0011] One particularly attractive target for small-molecule modulation, with respect to antiangiogenic and antiproliferative activity is c-Met. The kinase, c-Met, is the prototypic member of a subfamily of heterodimeric receptor tyrosine idnases (RTKs) which include Met, Ron and Sea. Expression of c-Met occurs in a wide variety of cell types including epithelial, endothelial and mesenchymal cells where activation of the receptor induces cell migration, invasion, proliferation and other biological activities associated with invasive cell growth." As such, signal transduction through c-Met receptor activation is responsible for many of the characteristics of tumor cells. [0012] The endogenous ligand for c-Met is the hepatocyte growth factor (HOF), a potent inducer of angiogenisis, also known as "scatter factor" (SF). Binding of HOFto c-Met induces activation of the receptor via autophosphorylation resulting in an increase of receptor dependent signaling, which promotes cell growth and invasion. Anti-HGF antibodies or HGE antagonists have been shown to inhibit tumor metastasis in vivo (See: Maulik et al Cytoldne & Growth Factor Reviews 2002 13, 41-59). [00131 Tumor growth progression requires the recruitment of new blood vessels into the tumor from preexisting vessels as well as invasion, adhesion and proliferation of malignant cells. Accordingly, c-Met overexpression has been demonstrated on a wide 3 WO 2005/030140- PCT/US2004031523 variety of tumor types including breast, colon, renal, lung, squamous cell myeloid leukemia, hemangiomas, melanomas, astrocytomas, and glioblastomas. Additionally activating mutations in the kinase domain of c-Met have been identified in hereditary and sporadic renal papilloma and squamous cel carcinoma. (See: Maulik et al Cytokine & growth Factor reviews 2002 13, 41-59; Longati at al Curr Drug Targets 2001, 2, 41-55; Funakoshi et al Clinica Chimica Acta 2003 1-23). Thus modulation of c-Met is desirable as a means to treat cancer and cancer-related disease. [0014] The Eph receptors comprise the largest family of receptor tyrosine kinases and are divided into two groups, EphA and EphB, based on their sequence homology. The ligands for the Eph receptors are ephrin, which are membrane anchored. Ephrin A ligands bind preferentially to EphA receptors whilst'ephrin B ligands bind to EphB receptors. Binding of ephrin to Eph receptors causes receptor autophosphorylation and typically requires a cell-cell interaction since both receptor and ligand are membrane bound. [0015] Overexpression of Eph receptors has been linked to increased cell proliferation in a variety of tumors (Thou R 1998 Pharmacol Ther. 77, 151-181; Kiyokawa E, Takai S, Tanaka M et al 1994 Cancer Res 54, 3645-3650; Takai N Miyazaki T, Fujisawa K, Nasu K and Miyakawa. 2001 Oncology reports 8, 567-573). The family of Eph receptor tyrosine Idnases and their ephrin ligands play important roles in a variety of processes during embryonic development and also in pathological angiogenesis and potentially metastasis. Therefore modulation of Eph receptor kinase activity should provide means to treat or prevent disease states associated with abnormal cell proliferation such as those described above. [0016] Inhibition of EGF, VEGF and ephrin signal transduction will prevent cell proliferation and angiogenesis, two key cellular processes needed for tumor growth and survival (Matter A. Drug Disc. Technol. 2001 6, 1005-1024). EGF and VEGF receptors are previously described targets for small molecule inhibition. KDR and fit-4 are both VEOF receptors [0017] One particularly attractive target for small-molecule modulation is c-Kit. The proto-oncogene c-Kit was first identified as the oncogenic component of the acutely transforming Hardy-Zuckeman 4-feline sarcoma virus (Besmer et al Nature 1986 320:415-421). c-Kit (also called stem cell factor receptor or steel factor receptor) is a type 3 receptor tyrosine Idnase (RTK) belonging to the platelet-derived growth factor receptor subfamily. c-Kit binds the ligand stem cell factor (SCF), and triggers its multiple signal 4 WO 20051030140 PCT/US2004/031523 transduction pathways including Src family kinases, phosphatidyl-inositol 3 kinase, the Ras-Raf-Map kinase cascade, and phospholipase C (Broudy at al Blood 1999 94: 1979 1986; Lennartsson et al Oncogene 1999 18: 5546-5553 ; Timokhina at al EMBO 1 1998 17;6250-6262; Chian et al Blood 2001 98(5)1365-1373; Blume-Jensen et al Curr Biol 1998 8:779-782; Kissel et al EMBO J 2000 19:1312-1326; Lennartsson et al. Orcogene 1999 18: 5546-5553; Sue et al Blood, 199892:1242-1149; Lav etal EMBO J 1991 10:647 654). c-Kit is required for normal hematopoiesis, melanonogenesis, and gametogenesis. c-Kit is expressed in mast cells, immature myeloid cells, melanocytes, epithelial breast cells and the interstitial cells of Cajal (ICC). In mast cells, it is required not only for the differentiation, maturation, chemotaxis, and haptotaxis but also for the promotion of survival and proliferation. [0018] Mutations in c-Kit have been implicated in human disease. Mutations in the juxtamembrane domain am found in many human gastrointestinal stromal tumors, and mutations in the kinase domain are found in mastocytosis, germ cell tumors, acute-myeloid leukemia (AML), NK lymphoma, and other hematologic disorders (Hirota et al Science 1998 279:577-580; Singer at al J Clin Oncol 2002 203898-3905; Longley et al Proc Natl Aca Sci USA 1999: 1609-1614; Tian et al Am J Pathol 1999 154: 1643-1647; Beghini at al Blood 2000 95:726-727; Hongyo at al Cancer Res 2000 60:2345-2347). These mutations result in ligand-independent tyrosine kinase activity, autophosphorylation of c Kit, uncontrolled cell proliferation, Md stimulation of downstream signaling pathways. Overexpression of c-Kit and c-Kit ligand have also been described in other tumors including small-cell lung cancer, neuroblastomas, gynecological tumors, and colon carcinoma, which might result in autocrine or paracrine c-Kit activation. [0019] The overexpression of c-Kit has also been implicated in the development of neoplasia associated with neurofibromatosis type 1 (NF1). Mutations in the tumor suppressor gene NF1 lead to a deficiency in neurofibromin, a GTPase-activating protein for Ras. This deficiency results in abnormal proliferation of Schwann cells in the peripheral nervous system, and predisposes affected individuals to peripheral nerve sheath tumors (neurofibromas), astrocytomas (optic pathway gliomas), learning disabilities, seizures, stroles, macrocephaly, vascular abnormalities, and juvenile myelomonocytic leukemia (Lynch & Gutmann Neurol Clin 2002 20:841-865). Genetic experiments in mice demonstrate that haploinsufficiency at NF1 partially rescues some of the phenotypes associated with mutations in the gene for c-Kit, indicating that these genes function along 5 WO 2005/030140 PCT/US2004/031523 a common developmental pathway (Ingram, et al. J. Exp Med 2000 191:181-187). Also, c Kit is expressed in schwannoma cells from NF1 patients, but not in normal schwann cells (Ryan et aL J Neurosci Res 1994 37:415-432). These data indicate that elevated c-Kit expression and sensitivity to stem cell factor may play important roles in the development of proliferative disorders associated with NF-1. Therefore, c-Kit inhibitors may be effective chemotherapeutic agents for treaUng patients with NF-1. [0020] GISTs are the most common mesenchymal tumors of the gastrointestinal tract, and they are generally resistant to chemotherapy and radiation therapy. However, recent results with the c-KWBCR-Abl inhibitor STI571 indicate that targeting c-Kit may be an effective therapeutic strategy for this disease (Eisenberg & Mehren Expert Opin Pharmacother 2003 4:869M74). Malignant mast cell disease often suggests an extremely poor prognosis, and no reliable effective chemotherapeutic agents have been identified (Marone et al Leuk Res 2001 25:583-594). Systemic mast cell disorders have been treated with interferon-alpha, although the effectiveness of this therapy has been variable (Lehmann & Lammle Ann Hematol 1999 78:483-484; Butterfield Br J Dermatol 1998 138: 489-495). Therefore, activated c-Kit might serve as a therapeutic target in GISTs and mast cell disease, as well as other disorders associated with activated c-Kit. [0021] FIt-3 is normally expressed on hematopoietic progenitor cells and a subset of mature myeloid and lymphoid cells, where it modulates cell survival and proliferation. Flt-3 is constitutively activated via mutation, either in the juxtamembrane region or in the activation loop of the kinase domain, in a large proportion of patients with AML (Reilly Leuk Lymphoma 2003 44: 1-7). Also, mutations in fit-3 are significantly correlated with poor prognosis in AML patients (Sawyers Cancer Cell 2002 1: 413-415). [0022] Accordingly, the identification of small-molecule compounds that specifically inhibit, regulate and/or modulate the signal transduction of kinases, particularly including c-Met, KDR, c-Kit, flt-3, and fit-4, is desirable as a means to treat or prevent disease states associated witl abnormal cell proliferation and angiogenesis, and is an object of this invention. [00231 Quinolines and quinazolines bearing substitution, for example at the two, four, six and seven positions of their fused ring system have been shown to be particularly attractive targets for kinase inhibition by a number of groups. Conventional quinoline and quinazoline kinase inhibitors typically have fairly simple substitution about the quinoline or quinazoline fused ten-membered ring system, but recently more complex molecules are 6 WO 2005/030140 PCT/US2004/031523 being disclosed. For example, we have previously disclosed, in U.S. provisional patent applications 60/506,181 and 60/535,377 which are both incorporated by reference herein in their entirety for all purposes, that certain quinolines and quinazolines are particularly well suited as kinase modulators, more particularly inhibitors of for example c-Met, KDR, c-Kit, fIt-3, and flt-4. These molecules in some cases are particularly complex and although they can be made via conventional methods, more efficient routes are desirable, especially in a pharmaceutical setting. [0024] Conventional methods of making quinolines and quinazolines with the aforementioned substitution patterns usually involve linear construction of a quinoline or quinazoline template upon which relatively simple substitutions are appended. With the advent of more complex substitution about such quinolines and quinazolines videe supra), for example side chains containing cyclic and bicyclic systems with multiple functional groups, conventional methods of synthesis become problematic due to the linear or serial reactions used. Indeed, as such molecules become more complex and the utility of such complex groups is realized, the quinoline and quinazoline ring system becomes more of a sub-structure than a main structure of such inhibitors. Thus it is desirable to find more efficient methods of synthesis, particularly convergent syntheses which are an object of this invention. SUMMARY OF THE INVENTION [0025] In one aspect, the present invention provides compounds for modulating kinase activity and methods of treating diseases mediated by dnase activity utilizing the compounds and pharmaceutical compositions thereof. Diseases mediated by kinase activity include, but are not limited to, diseases characterized in part by migration, invasion, proliferation and other biological activities associated with invasive cell growth. In particular to this invention is modulation, even more particularly inhibition, of c-Met, KDR, c-Kit, flt-3, and flt-4. [0026] In another aspect, the invention provides methods of screening for modulators of c Met, KDR, c-Kit, flt-3, and flt-4 activity. The methods comprise combining a composition of the invention, a kinase, e.g. c-Met, KDR, c-Kit, flt-3, or fIt-4, and at least one candidate agent and determining the effect of the candidate agent on the c-Met, KDR, c-Kit, fit-3, or flt-4, activity. [0027] In yet another aspect, the invention also provides pharmaceutical kits comprising one or more containers filled with one or mom of the ingredients of pharmaceutical 7 WO 2005/030140 PCT/US2004/031523 compounds and/or compositions of the present invention, including, one or more kinase, e.g. c-Met, KDR, c-Kit, fit-3, or flt-4, enzyme activity modulators as described herein. Such kits can also include, for example, other compounds and/or compositions (e.g., diluents, permeation enhancers, lubricants, and the like), a device(s) for administering the compounds and/or compositions, and written instructions in a form prescribed by a governmental agency regulating the manufacture, use or sale of pharmaceuticals or biological products, which instructions can also reflects approval by the agency of manufacture, use or sale for human administration. [0028] In another aspect, the invention also provides a diagnostic agent comprising a compound of the invention and, optionally, pharmaceutically acceptable adjuvants and excipients. [0029] In still yet another aspect, the present invention provides processes for making compounds, and pharmaceutical compositions thereof, for modulating kinase activity and treating diseases mediated by kinase activity. In particular to this invention are methods for making quinolines and quinazolines used for modulation of kinase activity, even more particularly inhibition of kinase activity, and yet even more particularly inhibition of c Met, KDR, c-Kit, flt-3, and flt-4. [0030] These and other features and advantages of the present invention will be described, in more detail below with reference to the associated drawings. DETAILED DESCRIPTION OF THE INVENTION [0031] The compositions of the invention are used to treat diseases associated with abnormal and or unregulated cellular activities. Disease states which can be treated by the methods and compositions provided herein include, but are not limited to, cancer (further discussed below), immunological disorders such as rheumatoid arthritis, graft-host diseases, multiple sclerosis, psoriasis; cardiovascular diseases such as artheroscrosis, myocardioinfarction, ischemia, stroke and restenosis; other inflammatory and degenerative diseases such as interbowel diseases, osteoarthritus, macular degeneration, diabetic retinopathy. [0032] It is appreciated that in some cases the cells may not be in a hyper- or hypo proliferative and/or migratory state (abnormal state) and still require treatment. For example, during wound healing, the cells may be proliferating "normally", but 8 WO 2005/030140 PCT/US2004/031523 proliferation and migration enhancement may be desired. Alternatively, reduction in "normal" cell proliferation and/or migration rate may be desired. [0033] Thus, in one aspect the present invention comprises a compound for modulating dnase activity according to Formula I, zAr DA N A I or a pharmaceutically acceptable salt, hydrate, or prodrug thereof, wherein, R1 is selected from -H, halogen, -OR 3 , -NO 2 , -NHz, -NR 3

R

4 , and optionally substituted lower alkyl; A' is selected from =N-, =C(H)-, and =C(CN)-; Z is selected from -S(O)o-2-, -0-, and -NR-; Ar is either a group of formula U, or of formula M, A2 AP.(8, 2 )q G G >F2)qI H wherein,

R

2 is selected from -H, halogen, trhalomethyl, -CN, -NO 2 , -NH 2 , -OR', -NR 3

R

4 , -S(O)-2R 3 , -SO 2

NR'

3 , -C0 2

R

3 , -C(O)NR 3 R', -N(R 3

)SO

2

R

3 , -N(R)C(O)R 3

-N(R

3

)CO

2

R

3

,-C(O)R

3 , and optionally substituted lower alkyl; qis0 to4; O is a group -B-L-T, wherein B is selected from absent, -N(R1 3 )-, -N(SO2RI 3 )-, -0-, -S(0)o.2., and -C(=O)-; L is selected from absent, -C(=S)N(R' 3 )-, -C(=NR 1

')N(R

3 )- SO 2

N(R

13 ), -SO2 -C(=0O)N(RIS)-, -N(R')-, -C(=0O)C2-2alkylN(R 1)-, -N(R')C1.2alkylC(=O)-, -C(=O)Co.alkylC(=O)N(R)-, -Co.

4 alkylene-, -C(=O)Co.ialkylC(=)OR-, 9 WO 2005/030140 PCT/US2004/031523

-C(=NR

14 )CO.ialkyC(=O)-, -C(=0)-, -C(=O)Co.IalkylC(=O)-, and an optionally substituted four to six-membered heterocyclyl containing between one and three annular heteroatoms including at least one nitrogen; and T is selected from -H, -R', -Co 4 alkyl, -Co4alkylQ, -OCo-alkylQ, -CoaalkylOQ,

-N(R

3 )Co 4 alkylQ, -SO 2 Co 4 alkylQ, -C(=O)CO 4 alkylQ, -Co4akylN(R)Q, and -C(=0)N(R")Co 4 alkylQ, wherein each of the aforementioned Co 4 alkyl is optionally substituted; J is selected from -S(O)o-2-, -0-, and -NR"-; R3 is -H or R,;

R

4 is selected from optionally substituted lower alkyl, optionally substituted aryl, optionally substituted lower arylalkyl, optionally substituted heterocyclyl, and optionally substituted lower heterocyclylalkyl; or R3 and R4, when taken together with a common nitrogen to which they are attached, form an optionally substituted five- to seven-membered heterocyclyl, said optionally substituted five- to seven-meribered heterocyclyl optionally containing at least one additional annular heteroatom selected from N, 0, S, and P;

A

2 and A 3 are each independently selected from =N-, =C(R 2 )-; R5 is -H or optionally substituted lower alkyl; D is selected from -0-, -S(0)o--, and -NR' 5 -; e is either R 3 , or according to formula IV; y (Xi (x')p IV wherein X 1 , X, and optionally 3, represent the atoms of a saturated bridged ring system, said saturated bridged ring system comprising up to four annular heteroatoms represented by any of X1, X2, and 3 ; wherein, each X1 is independently selected from -C(R')R, -0-, -S(O)-, and -NRs-; 10 WO 2005/030140 PCT/US2004/031523 each X 2 is independently an optionally substituted bridgehead methine or a bridgehead nitrogen; each X 3 is independently selected from -C(R)R 7 -, -0-, -S(O)o-a-, and -NR 5 -; Y is either: an optionally substituted lower alkylene linker, between D and either 1) any annular atom of the saturated bridged ring system, except X2 when X 2 is a bridgehead nitrogen, or 2) any heteroatom, represented by any of R or R7; provided there are at least two carbon atoms between D and any annular heteroatom of the saturated bridged ring system or any heteroatom represented by any of R 6 or R; or Y is absent when Y is absent, said saturated bridged ring system, is directly attached to D via an annular carbon of said saturated bridged ring system, unless D is -SO 2 -, in which case said saturated bridged ring system, is directly attached to D via an any annular atom of said saturated bridged ring system; m and p are each independently 1-4; n is 0-2, when n =0, then there is a single bond between the two bridgehead X2'; R and R7 are each independently selected from -H, halogen, trihalomethyl, -CN, -NH2, -NO2 -OR 3 , -NR 3 R, -S(Q)-2R4, -SO 2

NR

3 Rt, -C0 2

R

3 , -C(O)NR 3 R, -N(R3)SOR4,

-N(R

3

)C(O)R

3 , -NCOzR 3 , -C(O)R 3 , optionally substituted lower alkyl, optionally substituted aryl, optionally substituted lower arylalkyl, optionally substituted heterocyclyl, optionally substituted lower heterocyclylalkyl, and a bond to either Y or D; or R6 and R7, when taken together are oxo; or R6 and R7, when taken together with a common carbon to which they are attached, forn a optionally substituted three- to seven-membered spirocyclyl, said optionally substituted three- to seven-membered spirocyclyl optionally containing at least one additional annular heteroatom selected from N, 0, S, and P; R8 is selected from -R 3 , Y, -SO 2

NR

3

R

4 , -CO 2 R, -C(O)NR 3

R

3 , -SOA4, and -C(0)R 3 ; R is selected from -H, -C(=O)R 3 , -C(=O)R 3 , -C(=O)SR 3 , -S0zR, -C(=O)N(R 3

)R

3 , and optionally substituted lower alkyl, 11 WO 2005/030140 PCT/US2004/031523 two R 13 , together with the atom or atoms to which they are attached, can combine to form a heteroalicyclic optionally substituted with between one and four of R 6 (, said heteroalicyclic can have up to four annular heteroatoms, and said heteroalicyclic can have 'an aryl or heteroaryl fused thereto, in which case said aryl or heteroaryl is optionally substituted with an additional one to four of R"; R1 4 is selected from -H, -NO 2 , -NH2, -N(R 3

)R

4 , -CN, -OR 3 , optionally substituted lower alkyl, optionally substituted heteroalicyclylalkyl, optionally substituted aryl, optionally substituted arylalkyl and optionaly substituted heteroalicyclic;

R'

5 is a group -Me-M 2 , wherein M' is selected from absent, -C(=S)N(R 3 )-, -C(=RMa)N(R"3)-, -so2N(R13)-, -SO2-, -C(=0)N(RI3)-, -C(=0)C(=O))N(Rll)-, -Co 4alkylene-, -C(=O)-, and an optionally substituted four to six-membered hetercyclyl annular containing between.one and three heteratoms including at least one nitrogen; and

M

2 is selected from -H, -Co-salkyl, alkoxy, -C(=O)COalkylQ, -C.

4 alkylQ, -OCo 4 alkylQ

-N(R

3 )Cg-alkylQ-, and -C(=O)N(R' 3 )Co 4 alky1Q; and Q is a five- to ten-membered ring system, optionally substituted with between zero and four of 0; Ra is selected from -1H halogen, trihalomethyl, -CN, -NO 2 , -NH 2 , -OR,, -NR34,

-S(O)

0

_-R

3 , -SOINR'R 3 , -C0 2

R

3 , -C(O)NR 3

R

3 , -N(R 3

)SO

2

R

3 , -N(R 3

)C(O)R

3 ,

-N(R

3 )COzR 3 , -C(O)R 3 , and optionally substituted lower alkyl; R is selected from -H, halogen, tialomethyl, -CN, -NO 2 , -NH 2 , -OR, -NR 3 Rt

-S(O)O.R

3 , -SO 2

NR

3 R, -CO2 3 , -C(O)NR 3

R

3 , -N(R 3 )SO2R', -N(R)C(O)R 3 ,

-N(R

3 )C0 2

R

3 , -C(O)R3, optionally substituted lower alkyl, optionally substituted aryl, optionally substituted heteroarylalkyl, and optiohally substituted arylalkyl; two of R 6 0 , when attached to a non-aromatic carbon, can be oxo; with the proviso, only when Ar is according to formula 11, if Y is a C1..

6 alkylene; Z is -NH- or -N(CH 3 )-; R' is a CI 4 alkyl optionally substituted in the 2-position by -OH or a C 1 . 4alkoxy group; R 2 is -H or halogen; n =0; and the atoms, X1, of one bridge of the saturated bridged ring system, when combined with both bridgehead atoms, X2, of the saturated bridged ring system, represent 1) either a pyrrolidine or a piperidine, and any atom, X or X 2 , of either of said pyrrolidine or said piperidine is attached to Y, then the other bridge of said saturated bridged ring system cannot be any one of -OC(O)CIH-, 12 WO 2005/030140 PCTUS2004/031523 -CH2OC(O)-, -OC(O)CH2CH-, -CH20C(Q)CHr, -CH 2 CH20C(O) -OC(O)CHNH-, -OC(Q)CH 2

N(C

1 4 alkyl)-, and -OC(O)CHzQ-; or 2) either a piperazine or a 4-(C 4 ukyl)-piperazine, and any atom, Xe or X 2 , of either of said piperazine or said 4-(C1.

4 alkyl)-piperazine is attached to Y, then the other bridge of said saturated bridged ring system, only when attached via the 2- and the 3-position of either of said piperazine or said 4-(Ci4Akyl)-piperazine, cannot be one of -CH 2 0C(O)CH-, -CH2CH 2 0C(O)-, and either of the two aforementioned bridges optionally substituted by one or two Cl-akyl groups; or 3) a piperazine, and any atom, X 1 or X 2 , of said piperazine is attached to Y, then the other bridge of said saturated bridged ring system, only when attached via the 3- and the 4-position of said piperazine, cannot be one of

-C(O)OCHI

2 CH2-, -CH 2 OC(O)Cr, and either of the two aforementioned bridges optionally substituted by one or two CI-2alkyl groups, and only when either of the two aforementioned bridges are attached to the 3-position of said piperazine via their left-hand end as depicted above; or 4) a 2-oxomopholine, said 2-oxomorpholine attached to Y via its 4-position, then the other bridge of said saturated bridged ring system, only when attached via the 5- and the 6-position of said 2-oxomorpholine, cannot be one of

-(CH

2 )-, -CH 2 WCH2-, -CHWCHCH 2 -, and -CH2CH 2 WCHr, wherein W is -0-, -S(0)0-2-, -NN-, or -N(Citalkyl)- wherein g is 2, 3, or 4; and with the proviso that when Z is-O-, Ar is according to formula , and the portion of G directly attached to Ar is selected from: H H H -N O -- N "Y N Y o 0 H 0 O N S H__N Y N 0 13 WO 2005/030140 PCT/US2004/031523 0,0 then Rt 0 must be of formula IV; and with the proviso that when Ar is phenylene or substituted phenylene, Z is -S(O)o-2 or . O - N -0-, then the portion of G directly attached to Ar cannot contain R 70

R

70 when R 70 is selected from -H, C 1

.

4 alkyl, and C.

4 alkoxyl. [0034] In one example, the compound is according to paragraph [0033], wherein Z is either -0- or -NR-. [0035] In another example, the compound Is according to paragraph [0034, wherein G is selected from the following:

R

1

R

1 3

R

13

RI

I I 1 1 (0 N N N 0 N % N1 N R14 O 0

R

13 R0 3 R3 N N NM Q E / -2E 02 2 1 R 13 R13 R I Q N N 0 rNNVu

R

1 3 R13 RIB O N O - 1 - 03 14 WO 20051030140 C/S04312 0- 1 N kA4 zN N 0l N % 01 R1 0 00 0-3 0 1 ' Y"N N -R3YN l 0 0 0 N N% 1 Q ~F)t% NYN ' 5 .. NK7% 12 03 WO 20051030140 PCTIUS2004/031523 13 13 131R3 R3 R3 1R 0-3 1 -0-2 N E11 o NO OR00BOR wherein wherein Q, R 20 , and R 13 are as defined above; each E is selected from -0

-N(R

13 )-, -CU 2 -, and -S(Q)or; M is selected frm -0-, -N(R' 3 )-, .- Cilr, and -C(=O)N(R')-; each V is independently either =N- or =C(H)-; each methylene in any of the above formulae is independently optionally substituted with R"; and RV is selected from halogen, trihalomnethyl, -CN, -NO 2 , -NH 2 , -OR 3 , -NR 3 Rt, -S(0) 0

-

4

R

3 , .- SO 2 NR3R 3 , -CO2R 3 , -C(O)NR 3

R

3 , -N(R 3

)SO

2

R

3 , -N(Rb)C(O)R 3 , -N(R 3 )COzR 3 , -C(0)R 3 , optinally substituted aryl, optionally substituted arylailkyl, heteroarylalkyl, and optionally substituted lower alkyl; two of R, together with the carbon or carbons to which they are attached, can combine to form a three- to seven-memnbered alicyclic or heteroalicydic, two of R , on a single carbon can be oxo. [0036] In another example, the compound is according to paragraph [0035], wherein Ar is according to one of formula i a, fb, and R sa. ( ) (Rt 2

)

1 -s (Rl 2 ) Ha p b 3a [0037] In another example, the compound is according to paragraph [0036), wherein D is -O- and R' is -OR.

[0038 tin another example, the compound is according to paragraph [0037], wherein -O-Rhe and R' are interchangeably located at the 6-position and 7-position of the quinazoline or quinoline according to formula I. [0039) In another example, the compound is according to paragraph [0038], wherein R 1 is -- nr -OCsakyl. 16 WO 2005/030140 PCT/US2004/031523 [0040] In another example, the compound is according to paragraph [0039], wherein A' is =N- or =C(H)-. [0041] In another example, the compound is according to paragraph [0040], wherein G is selected from:

A

13 0 3 1 3 3 1 2QN N NyN N N' 0ty 0 RR1 R R 3

(A

6

"

0 )0.

4 R 13 N 1 R E e 0

(R)

0 4 O O (R 0 1 01 wherein Q, R 2 o, R' 3 , E, and R" 0 are as defined above; each mnethylene in any of the above formulae, other than those in a depicted ring, is independently optionally substituted with RZ ; and RY is selected from halogen, trihalomethyl, oxo, -CN, -NO 2 , -NHz, -OR 3 ,

-NR

3 R4, -s(o..zR 3 , -so 2

NRR

3 , -C0 2

R

3 , -C(o)NRaR 3 , -N(R 3 )SO2R 3 , -N(Rb)C(O)R 3 ,

-N(R

3 )002R 3 , -C(O)R', optionally substituted aryl, optionally substituted arylalkyl, heteroarylalkcyl, and optionally substituted lower alkyl; two of RY, together with the carbon or carbons to which they are attached, can combine to form a three-- to seveni membered alicyclic or heteroalicyclic. [0042] In another example, the compound is according to paragraph [0041], wherein Q is selected from:_. 17 WO 2005/030140 PCT/US2004/031 5 23 wherein R 20 is defined as above, and P is a five- to seven-membered ring, including the two shared carbons of the aromatic ring to which P is fused, P optionally containing between one and three heteroatoms. [0043] In another example, the compound is according to paragraph [0042], wherein Ar is according to formula Ha, and G is selected from 0 H

(R

60 )o.0 0)--4 N N R 0 2 (R-2 )-2 wherein Q, R 20 , R' 3 , E, and R" are as defined above, and each methylene in any of the above formulae, other than those in a depicted ring, is independently optionally substituted with R"'; and Rt' is selected from halogen, tidhalomethyl, oxo, -CN, -NO 2 , -NH -OR, -- NR 3 Rt, -S( 0 o-R 3 , -SO 2

NR

3

R

3 , -C0 2

R

3 , -C(O)NR 3 , -N(R 3 )SQ2 3 , -N(R3)C(O)R',

-N(R

3 )C0 2

R

3 , -C(O)R 3 , optionally substituted aryl, optionally substituted arylalkyl, heteroarylalkyl, and optionally substituted lower alkyl; two of RE, together -with the carbon or carbons to which they are attached, can combine to form a three- to sevefl mnembered alicyclic or heteroalicyclic. [0044] In another example, the compound is according to paragraph [0042], wherein Ar is according to formula Ub, and G is selected from: H 0rH 0I NN N rO-2 (R6 ) H 18 WO 20051030140 PCT/US2004/031523 RIS E EH . H N N,'RF11 O O ")0o wherein Q, R2W ,IE, and R 6 are as defined above, and each methylene in any of the above formulae, other than those depicted in a ring, is independently optionally substituted with R 25 ; and R is selected from halogen, trihalomethyl, oxo, -CN, -NO2, -NL 2 , -OR 3 ,

-NR

3 R, -S(0)o-2R 3 , -SO 2 NR3R 3 , -CO2R 3 , -C(O)NR 3 R, -N(R)SO 2

R

3 , -N(R)C(O)R 3 ,

-N(R

3

)CO

2

R

3 , -C(O)R3, optionally substituted aryl, optionally substituted arylalkyl, heteroarylalkyl, and optionally substituted lower alkyl; two of R2, together with the carbon or carbons to which they are attached, can combine to form a three- to seven membered alicyclic or heteroalicyclic. [0045] In another example, the compound is according to paragraph [00443, wherein the methylene between the two carbonyls of the depicted formulae is di-substituted with either optionally substituted lower alkyl, or an optionally substituted spirocycle. [0046] In another example, the compound is according to either [0043] or paragraph [00441, wherein R 0 is a heteroalicylic or a C 1

.

6 alkyl-heteroalicylic. [00471] In another example, the compound is according to paragraph [0046], wherein at least one of R 2 is halogen. [0048] In another example, the compound is according to paragraph [0046], wherein R 0 is according to formula IV. [0049] In another example, the compound is according to paragraph [0048], wherein the saturated bridged ring system according to formula IV has a geometry selected from the group consisting of [4.4.0], [4.3.0], (4.2.0], [4.1.0], [3.3.0], [3.2.0], (3.1.0], [3.3.3], [3.3.2], [3.3.1], [3.2.2], [3.2.1], [2.2.2], and [22.1]. [0050] In another example, the compound is according to paragraph [0049], wherein Y is selected from -CH2CH2CH2CH 2 -, -CH2CH 2

CH

2 -, -CH 2

CH

2 -, -CH 2 -, and absent. [0051] In another example, the compound is according to paragraph [0050], wherein n is 0 and the saturated bridged ring system according to formula IV has a geometry selected from the group consisting of [4.4.0], [4.3.0], [4.2.0], [4.1.0], [3.3.0], [3.2.0], and [3.1.0]. 19 WO 2005/030140 PCT/US2004/031523 [0052] In another example, the compound is according to paragraph [0051], wherein said saturated bridged xing system contains at least one annular nitrogen or at least one annular oxygen. [0053] In another example, the compound is according to paragraph [0052), wherein said saturated bridged ring system contains -NR 8 -, wherein R' is selected from -1, optionally substituted lower alkyl, -CO2R 3 , -C(O)NR 3 R, ,SO 2 R', and -C(O)R 3 . [0054] In another example, the compound is according to paragraph [0052], wherein said saturated bridged ring system is of formula V, N U wherein U' is selected from -0-, -S(O)o.2-, -NR-, -CRR 7 -, and absent; and e is 0 or 1. [0055] In another example, the compound is according to paragraph [0054], wherein Y is

-CH

2 -. [0056] In another example, the compound is according to paragraph [0055], wherein 1' is -NR-, wherein RB is selected from -H, optionally substituted lower alkyl, -CO 2

R

3 , -C(O)NRR', -SO 2

R

3 , and -C(O)R 3 . [0057] In another example, the compound is according to paragraph [0055], wherein U 1 is -0-. [0058] In another example, the compound is according to paragraph [0055], wherein U' is absent. [0059] In another example, the compound is according to paragraph [0052], wherein Y is selected from -CH 2

CH

2 -, -CH2-, and absent. [0060] In another example, the compound is according to paragraph [0059], wherein said saturated bridged ring system is of formula VI, 9- 0 i0 Ril 20 WO 20051030140 PCT/US2004/031523 vi wherein R 9 , R' 0 , and R" are each independently selected from -H, and -OR 12 ; or

R

9 is selected from -H, and -OR", and R1 0 and R", when taken together, are either an optionally substituted alkylidene or an oxo;

R

12 is selected from -h -C(O)R 3 , optionally substituted lower alkylidyne, optionally substituted lower arylalkylidyne, optionally substituted lower heterocyclylalkylidyne, optionally substituted lower alkylidene, optionally substituted lower alkylidenearyl, optionally substituted lower alkylideneheterocyclyl, optionally substituted lower alkyl, optionally substituted lower alkylaryl, optionally substituted aryl, optionally substituted lower heterocyclylalkyl, and optionally substituted heterocyclyl; or two R' 2 's, when taken together, form 1) a corresponding spirocyclic ketal when said two R2's stem from R1 0 and R", or 2) a corresponding cyclic ketal when said two R2's stem from R9 and one of R 10 and R". [0061] In another example, the compound is according to paragraph [0060], wherein one of R 1 " and R" is -OR' 2 , wherein R1 is selected from -H, -C(O)R 3 , and optionally substituted lower alkyl; and R? and the other of R'O and R 1 are both -H. [0062] In another example, the compound is according to paragraph [0061], wherein Y is either -CH 2 - or absent, [0063] In another example, the compound is according to paragraph [0062), wherein R 9 is an alkyl group containing at least one fluorine substitution thereon. [0064] In another example, the compound issaccording to paragraph [0053], wherein said saturated bridged ring system is of formula VII. R-NfJ VII [0065] In another example, the compound is according to paragraph [0064], wherein Y is either -CHr or absent [0066] In another example, the compound is according to paragraph [0065], wherein R8 is methyl or ethyl, 21 WO 2005/030140 PCT/US2004/031523 [0067] In another example, the compound is according to paragraph [0053], wherein said saturated bridged ring system is of formula VII, VIII [0068] In another example, the compound is according to paragraph [0067], wherein Y is -CHr. [0069] In another example, the compound is according to paragraph (00681, wherein R8 is methyl or ethyl, (0070] In another example, the compound is according to paragraph [0052], wherein said saturated bridged ring system is of formula IX R3 N 'IX wherein U 2 is selected from -0-, -S(O)o.r, -NRs-, -CR 6

R

7 -, and absent. [0071] In another example, the compound is according to paragraph [0070], wherein R 3 of formula IX is selected from -H and optionally substituted alkyl. [0072] In another example, the compound is according to paragraph [0071], wherein U 2 is either -CR 6 R7- or absent. [0073] In another example, the compound is according to paragraph (00723, wherein U 2 is either -CHR 2 - or absent. 100741 In another example, the compound is according to paragraph [0073], wherein Y is -CHr. [0075] In another example, the compound is according to paragraph [0053], wherein said saturated bridged ring system is according to formula X. 22 WO 2005/030140 PCT/US2004/031523 X [0076] In another example, the compound is according to paragraph [0075], wherein R is methyl or ethyl. [0077] In another example, the compound is according to paragraph (0033], selected from Table 1. Table 1 Entry Name Structure N-[({3-fluoro-4-(6 (methyloxy)-7-{[(3aR,6aS)- F octahydrocyclopenta[c]pyrrol- N l 5-ylmethyl]oxyjquinazolin-4- N0[ yl)oxy]pheny1)amino)carbonoN NN thioyl]-2-phenylacetamide N N-{[(3-fluoro-4-f7 ((3aR,6aS)-2- F methyloctahydrocyclopenta[c) 2 pyrrol-5-yl]methyljoxy)-6- s 0 (methyloxy)quinazolin-4- H4 H N N yl]oxy}phenyl)amino]carbono N thioyl}-2-phenylacetamide N-{ [(4-{[6,7-' bis(methyloxy)quinolin-4- Z 0 N 3 y1]oxy}-3 fluorophenyl)(methyl)amino]c S arbonothioyl}-2- NAN phenylacetamide H 1-(4-{[6,7- 0 bis(methyloxy)quinolin-4 4 yljoxy}-3- NH fluorophenyl)imidazolidin-2-P one N 1-(4-{[6,7- bis(methyloxy)quinolin-4 5 yl]oxy)-3-fluorophenyl)-3- O\ N I (phenylmethyl)imidazolidin- 0 , - e & 0 2-one N 23 WO 2005/030140 PCT/US2004/031523 Table I Entry Name Structure 1-(4-{[6,7- -Q bis(methyloxy)quinolin-4- N o 6 y1]oxy-3-flauorophenyl)-3 (phenylacetyl)imdazolidin.-2- Nj~ one ethyl [(4-1[6,7 bis(methyloxy)quinolin-4- NH 0 7 yl]oxy}-3- N fluorophenyl)amino](oxo)acet ateN 0 N-{(4-{[6,7 bis(methyloxy)quinazolin-4- F 8 y1]amino}-3 fluorophenyl)aminolcarbonot I bioy1)-2-phenylacetamide N NH N'-(4-{[6,7- 0 bis(methyloxy)quinolin-4- F 9 yl]oxy}-3-fluorophenyl)-N- O methyl-N-(2- I N CO phenylethyl)sulfamide N N-(4-{[6,7 bis(methyloxy)quinolin-4- I F 10 ylloxy}-3-fluorophenyl)-3- N (pheayhmethyl)-1,2,4 oxadiazol-5-amine N 0 H F 1-(4-{[6,7- 11 bis(methyloxy)quinolin-4 yljoxy}-3- oz fluorophenyl)pipeidin-2-one N 24 WO 2005/030140 PCT/US2004/031523 Table 1 Entry Name Structure 0 0, N-(4-{[6,7- -0 12 bis(methyloxy)quinolin-4- ONH HN yloxy}-3-fluorophenyl)-N- /H (phenylmethyl)ethanediamide 0 N-(4-{ [6,7-F 13 bis(methyloxy)quinolin-4 yl]oxy}-3-fluorophenyl)-4- s phenyl-1,3-thiazol-2-amine N 0 N-(4-{[6,7- -0 14 bis(mthyloxy)quinolin-4- NH HN 14 yl]oxy}-3-fluorophenyl)-N'- 0 (2-phenylethyl)ethanediamide P N-(4-{[6,7- F o,2-OC / 15 bis(methyloxy)quinolin-4- H 6 yl]oxy}-3-fluorophenyl)- 1 phenylmethanesulfonamide /P N -0 N-(4-{[6,7- NH 16 bis(methyloxy)quinolin-4- 0 -0 yl]oxy}-3-fluorophenyl)-2 phenylethanesulfonamide N F 4-{ [6,7 bis(methyloxy)quinolin-4 17 yl]oxy}-3-fluoro-N (phenylmethyl)benzenesulfon amide N 25 WO 2005/030140 PCT/US2004/031523 Table 1 Entry Name Structure bis(methyloxy)quinolin-4- ~ F 18 yl oxy}-3-fluoro-N-methyI-N- - \ (phenylmethyflbenzenesulfon p0 amide N F 4-{[6,7- bis(mothyloxy)quinolin-4- -N 19 yljoxy}-3-fluoro-N-(2- 0 0 phenylethyl)benzenesulfonam /N\/ ide N 4-f[6,7 bis(methyloxy)quinolin-4- -0 0 20 yloxy}-3-fluoro-N-methyl-N- -N 20 (2- /P k phenylethyl)benzenesulfonam N ide N F 4-{[6,7- F -N bis(methyloxy)quinolin-4- \ /tN 21 y1]oxy}-3-fluoro-N-(3 phenylpropyl)benzenesulfona mide 1-(4-({[6,7- 22 bis(methyloxy)quinolin-4- N yl]oxy}-3- Op fluorophenyl)pyrrolidin-2-one N N 4-{[6,7- -N 23 bis(methyloxy)quinolin-4- 0 ylloxy}phenyl (phenylmethyl)carbamate / I 26 WO 2005/030140 PCT/US2004/031523 Table 1 Entry Name Structure 4-{[6,7- O bis(methyloxy)quinolin-4- phenylethyl arbamate 4-{ [6,7 bis(methyloxy quinolin-4- ylloxy}-3-fluorm-N-methyl-N- o-N (3 phenylpropyl)benzenesulfona mide . N-(4-{[6,7- -- Ft N HO bis(nmthyloxy)quinoin-4- NH HN yl]oxy}-3-fluorophenyl)-N'- /P phenylethanediamide N N N-{[(3-fluoro-4-{f[7-{ [(2- F methyloctahydrocyclopenta[c]F 27 pyrrol-5-yl)methyl]oxy}-6 (methyloxy)quinolin-4: yl]oxy}phenyl)amino]carbono N thioyl}-2-phenylacetamideN N-[(Z)-[(4-{[6,7- 0 bis(methyloxy)quinolin-4- F 28ylloxy}-3- 0 N fluoropheny)amino](imino)m ethyl]-2-phenylacetamide N H H 4.-{[6,7- ~ ~ bis(methyloxy)quinolin-4 29 yl]oxy)-3-fluoro-N-[2- /0 0 (phenyloxy)ethyl]benzenesulf \ onam e 27 WO 2005/030140 PCT/US2004/031523 Table 1 Entry Name Structure N,N-(4-{[6,7- N bis(metbyloxy)quinoliu-4- / 30 yl]oxy}-3-fluorophenyl)-bis- / (3-phenylpropane-1 sulfonamide) N-(4-{[6,7- F 31 bis(methyloxy)quinolin4 -0 yl]oxyj-3-fluorophenyl)-3. -NH phenylpropane-1-sulfonamide 0? N. N2-[(4-{[6,7 bis(methyloxy)quinolin-4- - 32 y1]oxy}-3- 0 0 fluorophenyl)sulfonyl]-N1- /O phonylgycinamide N N-(6-{[6,7 33 bis(methyloxy)quinolin-4 ylloxy}pyidin-3-yl)-2 phenylacetamide N N N H N-{{(6-{[6,7- oN bis(methyloxy)quinolin-4 34 yl]oxy}pyridin-3- 0 yl)amino]carbonothioyl}-2 phenylacetamide N/ N N N H H 6-1[6,7- -- 0.-..-iSoN-2 35 bis(methyloxy)quinolin-4- \-/; N yl]oxy}-1,3-benzothiazol-2-O amine\ N 28 WO 2005/030140 PCT/US2004/031523 Table 1 Entry Name Structure 6-{[6,7-

-

H 36 bis(methyloxy)quinolin.-4- N y1]oxy}-5-fluoro-1,3 benzothiazol-2-amine N N-(6-{[6,7 bis(methyloxy)quinolin-4- 37 yL]oxy}-5-fluora-1,3 benzothiazol-2-yl)-2- 0 F phenylacetamide N N-(4-{ [6,7-. bis(methyloxy)quinolin-4 38 yl]oxy}-3-fluoropheny1)-N'- N H N (2-morpholin-4- / \ ylethyl)ethanediamide N 0 benzy]-{ [4-(6,7-dimethoxy- O 39 quinolin-4-yloxy)-3-fluoro- A 0 0 phenylcarbamoylj-methyl}-. Oo carbamic acid tert-butyl ester NN N - H NI-(4-{[6,7- O F 40 bis(methyloxy)quinolin-4 yl]oxy}-3-fluorophenyl)-N2 (phenylmethyl)glycinamide N H N2-acetyl-NI-(4-{[6,7- 0 F 41 bis(methyloxy)quinolin-4- Y O yl]oxy}-3-fluorophenyl)-N2- 0 (phenylmethyl)glycinamide NN N H 29 WO 2005/030140 PCT/US2004/031523 Table 1 Entry Name Structure N-(6-{[6,7- 42 bis(mothyloxy)quinolin-4- N ylloxy}-1,3-benzothiazol-2- p yl)-2-phenylacetamide/ N benzyl-{ [6-(6,7-dimethoxy- - N 43 quinolin-4-yloxy)-pyridin-3- O N ylcarbamoyl]-methyl}- O carbamic acid text-butyI ester N oN N H N1-(6-{[6,7 44 bis(methyloxy)quinolHn-4- 0 ylloxylpyridin-3-yl)-N2- N0 (phenylmethyl)glycinamide N No,, I H N2-acetyl-N1-(6-{ [6,7- 0 y1]oxyjpyridin-3-yl)-N- f AC N (phenylmethyI)glycinamide NN N N H '%_0 N-(6-f[6,7- -o 46 bis(methyloxy)quinolin-4- / yl]oxy}pyridin-3-yl)-3- N phenylpropanamaide\/ N-(6-{[6,7- o0 47 bis(methyloxy)quinolin-4 yl]oxy}pyridin-3-yl)-4- N / o phenylbutanamide N / N N H 30 WO 2005/030140 PCT/US2004/031523 Table 1 Entry Name Structure N1-(6-{[6,7- 0 bis(methyloxy)quinolin-4- I N 48 yl]pxy}pyridin-3-yl)-N2- I 0O N KN ,I methyl-N2- I (phenylmethyl)glycinamide N A"o H N-(4-{[6,7 bis(methyloxy)quinolin-4- -0 F 4 49 yl]oxy}-3-fluorophenyl)-N'- NH HN {2-[4 (methyloxy)pheny1]ethyl}etha nediamide NL-(4-{[6,7 bis(methyloxy)quinolin-4- F 50 yI]oxy}-3-fluorophonyl)-N2- I methyl-N2- N (phenylhnethyl)glycinamide N A H SNH2 4-[(2-amino-1,3-benzothiazol- 0H 51 6-yl)oxy]-6,7-bis(methyloxy) 1-(2-oxo-2 N+ phenylethyl)quinolinium N-{1[(4-{[6,7- , 52 bis(methyloxy)quinolin-4 yflamino}pheny1)aminocarbo N o nothioylj-2-phenylacetamide N Ao N-(6-{[6,7.. O" bis(methyloxy)quinolin-4- -0 r I yI]oxy}-5-fluoro-1,3 benzothiazol-2-yI)-3- ? F phenylpropanamide N 31 WO 2005/030140 PCTUS2004/031523 TabIe 1 Entry Name Structure N-{[(6-{[6,7 bis(methyloxy)quinolin-4- c 54 yl]oxy}-5-chloropyridin-3- N yl)amino]carbonothioyl}-2 phenylacetamide N / N J H H N-(4-{1[6,7- F O& O bis(methyloxy)quinolin-4- -o 55 yl]oxy}-3-fluorophenyl)-N'- - 0b NH HN (2,3-dihydro-1H-inden-1 yl)ethanediamide N N-(4-{[6,7- 0 0 bis(methyloxy)quinolin-4- -H 56 yl]oxy}-3-fluorophenyl)-N (2,3-dihydro-1H-inden-2- / yl)ethanediamideN N-(4-{[6,7- 0 0 bis(methyloxy)quinohn-4- 57 yl]oxy}-3-fluorophenyl)-N'- - b NH HN (1,2,3,4-tetrahydronaphthalen- 0 1-yl)ethanediamide N N'-(4-{[6,7- . bis(methyloxy)quinolin-4- NH 58 yl]oxy}-3-fluorophenyl)-N- o ,0 (2-phenylethyl)-N- / N (phenylmethyl)sulfamide N N1-(4-{[6,7 59 bis(methyloxy)quinolin-4- NH F F yljoxy}-3-fluorophenyl)-N2 (trifluoroacetyl)glycinamide N 32 WO 2005/030140 PCT/US20041031523 Table 1 Entry Name Structure N-{[4-(6,7-dimethoxy- O N 60 quinolin-4-yloxy)-3-fluoro - O NH phenylcerbanioyl]-methyl} benzamide / N N-(6-{1[6,7- .O 61 bis(methyloxy)quinolin-4- F yl1]oxy}pyridin-3-y)-N'-(4- / V P fluorophenyl)propanediamide NN N-(4-{ [6,7 bis(methyloxy)quinolin-4- - O 62 yljoxy}-3-fluorophenyl)-N'- NH HN [(2S)-1,2,3,4- 0 tetrahydronaphthalen-2 yl]ethanediamide N- (4-{f[6,7-0 bis(methyloxy)quinolin-4- 63 yljoxy}-3-fluorophenyl)-N'- NH H [2-(4 methylphenyl)ethy1]ethanedia mide N-(4-{[6,7- -O F O bis(methyloxy)quinolin-4- NH HN 64 yl]oxy}-3-fluorophenyl)-N'- 0 (2 phBenylpropyl)ethanediamide N N-(4-{[6,7- F bis(methyloxy)quinolin-4 65 y1]oxy}-3-finorophenyl)-N'- ib 5 NH HN [2-(4- 0o_ c chlorophenyl)ethyl]ethanedia mide 33.

WO 2005/030140 PCT/US2004/031523 Table 1 Entry Name Structure N-(4-{[6,7 66 bis(methyloxy)quinolin-4- 0 y1]oxy}-3-fluorophinyl)N,N'- N / bis(phenylmethy)sulfamide N-(4-{[6,7- --- I 67 bis(methyloxy)quinolin-4- N yI]oxy}-3-fluorophenyl)-NN'- 70 bis(2-phenylethyl)sulfamide NH N CI 0 0 ethyl [(6-f [6,7- - ' CO 68 bis(methyloxy)quinolin-4- NH 0 yljoxyj-5-chloropyridin-3- O yl)amno](oxo)acetateN N-(6-{[6,7- -0 0 - bis(mothyloxy)quinolin4- N N 69 y y l o }o rdi-- 0 N-(6-{[6,7 bismethyloxy)quinolin-4- 11 NC1 70 yl]oxy}-5-chloropyridin-3- F yl)M-4.'[I NO jToo0y F fluoropheny propanediamide N N N-(4-{[6,7- F0 bis(methyloxy)quinolin-4- -H 71 yl]oxy}-3-fluorophenyl)-N' (1,2,3,4-tetrahydronaphthalen 2-yl)ethanediamide N 34 Wo 2005/030140 PCT/US2004/031523 Table 1 Entry Name Structure N-(4-f [6,7 bis(mthyloxy)quinolin-4- -H 72 yl]oxy}-3-fluorophenyl)-N'- 0 [2-(1-methylpynolidin-2 yI)ethylethanediamide N-(4-([6,7- 0 O bis(mothyloxy)quinolin-4 73 yl]oxy)-3-fluorophenyl)-N'- -NH HN (phenyloxy)ethyl]ethanediami N N-(4-{[6,7- 0 bis(methyloxy)quinolin.4- F 74 yI]oxy}-3-fluorophenyl)-N'- 0 OH (2-hydroxy-1 (phehylmethyl)ethyljurea N 1-(4-{[6,7 bis(methyloxy)quinolin-4-

.

N 75 yl]oxy}-3-fluorophenyl)-3- N [(4-mnethylphenyl)sulf'onyl]--4- 0 (phenylmethyl)imidazolidin- F 2-one N N'-(4-{[6,7- -o F O bis(methyloxy)quinolin-4- NH N- 76 yl]oxyj-3-fluorophenyl)-N methyl-N-(2 phenylethyl)ethanediamide N N-(4-{[6,7- -0 F O bis(methyloxy)quinolin-4- 0 NH HN 77 yl]oxy}-3-fluoropheny)-N'- 0 {[3 (trifluoromethyl)phenyllmeth N yl}ethanediamide F 35 WO 2005/030140 PCT/US2004/031523 - Table 1 Entry Name Structure N-(4-{[6,7- F 0 bis(methyloxy)quinolin-4- 78 ylloxy}-3-fluoropheny)-N'- N {2-13- / : (trifluoromethyl)phenyl]ethyl N F }ethanediamide N-(6-{[6,7 bis(methyloxy)quinolin-4- A1 79 yljoxy}-5-chloropyridin-3 yl)-3-oxo-4- 0) phenylbutanamide N N H N-(6.-{[6,7 bis(methyloxy)quinolin-4- 0 C 80 yl]oxy}-5-chloropyridin-3 yl)-2-[3- I F (trifluoromethyl)phenyl]aceta N N NF H- F F 6-{ [6,7 bis(methyloxy)quinolin-4- - 81- yl]oxy}-5-fluoro-N-[2- (phenyloxy)ethyl]-1,3 benzothiazol-2-amine F N 6-{[6,7- N bis(methyloxy)quinolin-4- -o 82 yl]oxy}-5-fluoro-N-(2- - c0 / piperidin-1-ylethyl)-1,3- P F beuzothiazol-2-amine F 6-{{6,7 bis(methyloxy)quinolin-4- - N 83 yljoxy}-5-fluoro-N-methyl-N- N (2-phenylethyl)-1,3- 0 benzothiazol-2-amine N/ 36 WO 2005/030140 PCTIUS2004/031523 Table 1 Entry Name Strcture 6-{ [6,7-

&

1 1 bis(mothyloxy)quinolin-4- - N 84 ylloxy}-5-fluoro-N-(2- 0 N pynolidin-1-ylethyl)-1,3-F benzothiazol-2-amine N F 6-{[6,7- F bis(methyloxy)quinolin-4- 85 yl]oxy)-5-fluoro-N-{[3- N F (trifluoromethyl)phenyl]meth / yl}-1,3-benzothiazol-2-amine F N 6-{[6,7 bis(methyloxy)quinolin-4- -0 86 ylloxy}-5-fluoro-N-{2-[3- 0 N (tdfluoromethyl)phenyl]ethyl F F F }-1,3-benzothiazol-2-amrne N F F N-(6-{[6,7- o bis(methyloxy)quinolin-4 87 yljoxy}-5-chloropyridin-3- 0 87yl)-N-[3- 0 (tifluorometbyl)phonylpropa NN nediamide H H N-(6-{[6,7- s Y bis(methyloxy)quinolin-4- N 88 yl]oxy}-5-fluoro-1,3 benzothiazol-2-yl)-2-[3- P / . (trifluoromethyl)phenyllaceta F F i& FFF N1-(4-{{6,7- o bis(methyloxy)quinolin-4- / F 89 yl]oxy}-3-fluoropheny)-N2- J (trifluoromethy)phenyl]metb NN yl glycinamide F 37 WO 2005/030140 PCT/US20041031523 Table 1 Entry Name Structure N1-(4-{ [6,7 90 bis(methyloxy)quinolin-4- yljoxy)-3-fluorophenyl)N2- NH (2-phenylethyl)glycinamide p N NI-(4-{[6,7 bis(methyloxy)quinolin-4-F 0 N 91 yl]oxy}-3-fluorophenyl)-N2- -0 N F F (trifluoromethyl)phonyllethyl P Iglycinamide N benzyl-{[5-chloro-6-(6,7 dimethoxy-quinolin-4-yloxy)- C 92 pyridin-3-ylcarbamoyl]- 0 0 0 O methyl}-carbamic acid tert- I butyl ester N N H N1-(6-{ [6,7 bis(methyloxy)quinolin-4- Cl 93 yI]oxy}-5-chloropyridin-3 yl)-N2- N (phenylmethyl)glycinamide N A N N H N-(6-{[6,7-. * 0F bis(methyloxy)quinolin-4- N 94 yl]oxy}-5-finoro-1,3- /|F benzothiazol-2-yl)-2-13,5- t F \ I bis(trifluoromethyl)phenyl]ac N F F etamide F F N-(6-([6,7 bis(methyloxy)quinolin-4- s 0 yl]oxy}-5-fluoro-1,3- -0 F F 95 benzothiazol-2-yl)-2-[2- N F chloro-5-e (trifluoromethyl)phenyl]ace-ta N FC mideN 38 WO 2005/030140 PCT/US2004/031523 Table 1 Entry Name Structure F0 N-f 3-fluoro-4-[(6- -o (methyloxy)-7-{[(1- \ / NH HN 96 methylpiperidin-4 yl)methylloxy)quinolin-4- N3 yl)oxyjphenyl}-N'-(2 phenylethyl)ethanediamiide N-(4-{[6,7 bis(methyloxy)quinolin-4- -o 97 ylloxy}-3-fluorophenyl)-N'-

-

NH HN tetrahydtoisoquinolin-1- b-\/ HN ylmethyl)ethanediamide N N-(4-{[6,7 bis(methyloxy)quinolin-4 98 y1]oxy}-3-fluoropheny1)-N'- KI NH [(2-methyl-1,2,3,4- O tetrahydroisoquinolin-1 yl)methyllethanediamide N1-(4-{16,7 bis(methyloxy)quinolin4- o F 99 yl]oxy}-3-jumpnyl)-N2 methyl-N2-{[3-0 (trinuoromethyl)phenyllmeth N L N_ F yl)glyinamide H FF N1-(4-{[6,7 bis(methyloxy)quinolin-4- F N F 100 yl]oxy}-3-fluorophenyl)-N2- -- F methyl-N2-{2-[3- NH F (trifluoromethyl)phenyl]ethyl / k }glycinamide NI N1-(4-{[6,7-\ bis(methyloxy)quinolin-4 101 yl]oxy}-3-fluorophenyl)-Nq2~ NH methyl-N2-(2- a phenylethyl)glycinamide / 39 WO 2005/030140 PCT/US2004/031523 Table 1 Entry Name Structure 1-(4-{[6,7 bimethyloxy)quinolin-4- -o 102 yl]oxyj-3-fluorophenyl)-4- 0NH (phenylmethyl)imidazolidin- / \ 2-one 0 N-(6-f[6,7- o I 103 bis(methyloxy)quinalin-4- F yl]oxy}pyridazin-3-yl)-N'-(4- 0 0 fluomphenyl)propanediamide N / N-(6-{[6,7- ci bis(methyloxy)quinolin-4 104 yl]oxy}-5-chloropyridin-3- N yl)-N'-(2- 0I chlorophenyl)propanediamide N N Ci N-(6-{ [6,7 bis(methyloiy)quinolin-4- A N CI 105 yl]oxy}-5-chloropyridin-3 yl)-N'-(3- N ) chlorophenyl)propanediamide N N Cl N1-(6-{ [6,7- 0 bis(methyloxy)quinolin-4- ci 106 y1]oxy}-5-chloropyridin-3- N yI)-N2-methyl-N2- 0) (phenylmethyl)glycinamide N N N N-(6-{[6,7 bis(methyloxy)quinoin-4-- 11 N cl 107 yl]oxy}-5-chloropyridin-3- 0 0 N , ci chlorophenyl)propanediamide H N 40 WO 2005/030140 PCT/US2004/031523 Table 1 Entry Name Structure (2E)-N-(4-{[6,7 bis(methyloxy)quinolin-4- NH N 108 ylloxy}phenyl)-2- O [(methyloxy)iminojpropanami N (2E)-N-(4-{[6,7 bis(methyloxy)quinolin-4- -N 109 yl]oxy}phenyl)-2- 0 [(ethyloxy)imino]propanamid / c N (2E)-N-(4-{(6,7 bis(methyloxy)quinolin-4- N N 110 yl]oxyphenyl)-2 i(phenyhnethyl)oxy]imino}p / ropanamide 0 N-(4-f[6,7- AqN 11 bis(methyloxy)quinolin-4- N yl]oxy}pheny)-1 (phenylmethyl)prolinamide N H 1-(4-{ [6,7 bis(methyloxy)quinolin-4 112 yI]oxyjphenyQ)-3-[(4- -o methylphenyl)sulfonyl]-4- N 0 (phenylmethyl)imidazolidin- / 2-one N bis(methyioxy)quinolin-4- 113 yi]oxy}phenyl)-4- O NNH (phenylmethyl)imidazolidin- / 0 2-one N 41 WO 2005/030140 PCT/US2004/031523 Table 1 Entry Name Strcture N-(4-{[6,7 bis(methyloxy)quinolin-4- .A 114 yl]oxy}phenyl)4 (phenylmethyl)-4,5-dihydro- I 1,3-oxazol-2-amineN 6,7-bis(methyloxy)-4-({4-[4-. 115 (phenylmethyl)piperazin-1- - O yI]phenyl}oxy)quinoline 1-(4-{[6,7 bis(methyloxy)quinolin-4- 116 yl]oxy}phenyl)-4- - .0 \&/ N N (phenybnethyl)piperazin-2 one/ N N1-(4-{[6,7- -o 117 bis(methyloxy)quinolin-4- NH HN 117 yl]oxy}phenyl)-N2-. O HH (phenylmethyl)alaninamide N N N1-(4-f[6,7- -o bis(methyloxy)quinolin-4- - NH N 118 yl]oxyjphenyl)-N2-methyl- o N2 (phenylmethyl)alaninamide N N1-(4-{[6,7- -0 119 bis(methyloxy)quinolin-4- NH HN yljoxylphenyl)-N2- ._ (phznylmethyl)Leucinamide 4N 42 WO 2005/030140 PCTUS2004/031523 Table 1 Entry Name Structure N1-(4-{[6,7- O bis(methyloxy)quinolin-4- -o 120 yfloxy}pheny1)-N2-methyl- \ / NH N (phenyImethyl)1eucinamide N N1-(4-{[6,7- -o bis(methyloxy)quinolin-4- NH HN yl]oxy}phenyl)-N2- 0 (phenylmethyl)valinamide / N N 4-(6,7-dimethoxy-quinolin-4- H 122 ylamino)-N-(3-phenyl- N propyl)-benzamide N I0 IN0 4-benzyl-1-[4-(6,7 123 dimethoxy-quinolin4-yloxy) phenyl]-tetrahydro-pyrimidin- N 2-one N)N M N N-{3-Fluoro-4-[6-methoxy-7- F 124 (piperidin-4-ylmethoxy)- O gninolin-4-yloxy]-pheny}-N'- N ( N&4 phenethyl-oxalamide HH 43 WO 2005/030140 PCT/US2004/031523 Table 1 Entry Name Structue 2-(Benzy-methy-amino)-N [4-(6,7-dimethoxy-quinolin-4- O yloxy)-phenyll-3-methyl 125 butyramide (note: Alphabetic order of N prefixes ignored while selecting parent chain)

N*

0 N-[4-(6,7-Dimethoxy 126 quinolin-4-yloxy)-phenyl]-2 phenoxyimino-propionamide I

N

0 N 2-Benzyloxyimino-N-[4-(6,7- 0 127 dimethoxy-quinolin-4-yloxy) phenyl]-2-phenyl-acetamide N NO 00 4-[4-(4-Benzyl-piperidin-1- N 128 yl)-phenoxy]-6,7-dimethoxy quinoline NN N N N-[4-(6,7-Dimethoxy- F quinolin-4-yloxy)-3-fluoro- 0 129 pheny1]-N'-(2-isopropyl- N 0 1,2,3.,4-tetrahydro isoquinolin-1-ylmethyl)- HN oxalamideN WO 2005/030140 PCT/US2004/031523 Table 1 Entry Name Structure

'-

0 AN F N-[4-(6,7-Dimethoxy- 0 quinolin-4-yloxy)-3-fluoro 130 phenyl]-N'-(2-ethyl-1,2,3,4- N. O tetrahydro-isoquinolin-1 HN ylmethyl)-oxalamide 4-(4-{3-Chloro-5-[2-(4- r1 fluoro-phenylcarbamoyl)- K0> 131 acetyaino]-pyridin-2- N 11 yloxy}-6-methoxy-quinolin--. N N NU NH yloxymethyl)-piperidine-1- c0ciK H carboxylic acid tert-butyl ester F 0 N-{5-Chloro-6-[6-methoxy-7 (piperidin-4-ylmethoxy)-0 quinoin-4-yloxyl-pyrd5in-3~ N 132 yl}-N'-(4-fluoro-phenyl)- N N N NH malonamide H H F 0O N Cl N-{5-Chloro-6-[6-methoxy-7- 1 (1-methyl-piperidin-4- N 0 133 ylmethoxy)-quinolin-4- N N / N N yloxy]-pyridin-3-yl)-N'-(4- H fluoro-phenyl)-malonamide F 45 WO 2005/030140 PCT/US2004/031523 Table 1 Entry Name Structure N-{4-[7-(3-Diethylamino- O 0 propoxy)-6-methoxy 134 quinolin-4-yloxy]-3-fluoro- N phenyl}-N'-phenethyl-- F N oxalamide

"*

0 F N-{3-Fluoro-4-[6-methoxy-7 135 (3-morpholin-4-yl-propoxy)- N N N quinoin-4-yloxy]-phenyl}-N- H phenethyl-oxalamide H HN

N

0 O F N-{3-Fluoro-4-[6-methoxy-7- j 136 (3-pipeniin-1-yl-propoxy)- N N 0 quinolin-4-yloxy]-pheny}--N I phenethyl-oxalamide HN O F N-{4-[7-(2-Diethylamino- N O ethoxy)-6-methoxy-quinolin- N K 137 4-yloxy]-3-fluoro-phenyl}-N'- N phenethyl-oxalamide 46 WO 2005/030140 PCT/US2004/031523 Table 1 Entry Name Structure N F N-{3-Piuoro-4-[6-methoxy-7- F (1-methyl-pipeidin-4 138 ylmethoxy)-quinolin4- N N yloxy]-pheny1}-N'-methyl-N'- |H N phenethyl-oxalamide 0 e N-{3-Fluoro-4-[6-methoxy-7- F (2-methyl-octahydro- 0 139 cyclopenta[c]pyrrol-5- H H N & ,,U O ylmethoxy)-quinolin-4- N yloxy]-phenyl}--Nphenethy- N HN oxalamide N-{3-Fluoro-4-[6-methoxy-7- F (2-methyl-octahydro- N 10 cyclope-nta[c]pyrro1-5- H H N NO 140 yhnethoxy)-quinazolin-4- H40N yloxy]-phenyl}-N'-phenethyl- N HN oxalamide 0 2-(3,4-Dihydro-1H- F isoquinolin-2-yl)-N-{3-fluoro- o 141 4-[6-methoxy-7-(1-methyl- N piperidin-4-ylmethoxy)- N N quinolin-4-yloxy]-phenyl}-2- N oxo-acetamide 47 WO 2005/030140 PCT/US2004/031523 Table 1 Entry Name Structure 0 0 N F N-{3-Fluoro4-{6-methoxy-7- 0 (piperidin-4-ylmthoxy) 142 Nqinoln--yloxy]-phenyl}-2- N N N O oxo-2-(3-phenyl-pyrrolidin-1- H N yl)-acetamide ON K F N-{3-Fluoro-4-[6-methbxy-7 (piperidin-4-yhnethoxy)- N 143 quinolin-4-yloxy]-phenyl}-2- N N A oxo-2-(2-phenyl-morpholin-4- H H N yl)-acetamide F N N-(2-Dimethylamino-2- O phenyl-ethyl)-N'-{3-fluoro-4 144 [6-methoxy-7-(piperidin-4- N A ylmethoxy)-quinolin-4- H H HN yloxy]-phenyl}-oxalamide N OF N-{3-Fluoro-4-[6-methoxy-7- 0 (piperidin4-ylmethoxy)- 5 0 145 quinolin-4-yloxy]-phenyl}-N'- NN O (2-oxo-2-phenyl-ethyl)- HHH oxalamide 48 WO 2005/030140 PCT/US2004/031523 Table 1 Entry Name Structure 0 Cl N-[5-Chlor-6-(6,7- I N 00 146 dimethoxy-quinolin-4-yloxy)- N Nj pyridin-3-yI]-2,2-difluoro-N'- N 1 N V-- NH (4-fluoro-phenyl)-malonamide F N-Benzy-N'-{3-fIuoro-4-[6- F methoxy-7-(1-methyl 147 piperidin-4-ylmethoxy)- N quinolin-4-yloxy]-phenyl}- H HN oxalamide NF N-{3-Fluoro-4-[6-methoxy-7 (piperidin-4-ylmethoxy) 148 quinolin-4-yloxy]-pheny)-N N A [2-(2-fluoro-phenyl)-ethyl}- H H H oxalamide F N N F N-[2-(3-Chloro-phenyl)- C ethyl]-N'-{3-fluoro4-[6- A N 149 methoxy-7-(pipeidin-4- H - HN yhnethoxy)-quinolin-4 yloxy]-phenyl}-oxalamide 49 WO 2005/030140 PCT/US20041031523 Table I Entry Name Structure F N-{3-Fluoro-4-[6-methoxy-7- 0 (pipridin-4-ylmethoxy)- 150 quinolin-4-yloxy]-phenyl}-N- N N [2-(2-methoxy-phenyl)-ethylj]- H HN oxalamide N-{3-Fluoro-4-[6-methoxy-7- b (piperidin-4-ylmethoxy)- 1 151 quinolin-4-yloxy]-phenyl}-N'- N N o (2-pyridin-3-yi-ethyl)- H HN oxalamide N 1.0 F N-Benzyl-N'-{3-fluoro-4-[6 methoxy-7-(piperidin-4- N 152 ylmethoxy)-quinolin-4- N yloxy]-phenyl}-oxalamide H 0 N-[2-(2,5-Dimethoxy phenyl)-ethyll-N'-{3-fluoro-4- N N 153 [6-methoxy-7-(piperidin-4- H, ylmethoxy)-quinolin4 HN yloxy-phenyl}-oxalanide 50 WO 2005/030140 PCT/US2004/031523 Table 1 Entry Name Structure

'-

0 0 N-{3-Fluoro-4-{6-methoxy-7 (piperidin-4-yhnethoxy) 154 quinolin-4-yloxy}-phenyl}-N'~ No 0NZ' O [2-(2-trifluoromethyl-pheny1)- H HN F ethyl]-oxalamide N '0 F N-[2-(2-Ethoxy-phenyl) 0 F ethyl]-N'-{3-fIuoro4-[6- 0 155 methoxy-7-(piperidin-4- N yhnethoxy)-quinolin-4- H H HN yloxy-phenyl}-oxalamide

N

0 N-[2-(2,4-Dimethyl-phenyl)- ethyl]-N'-{3-fluoro-4-[6- N 156 methoxy-7-(piperidin4- N N O yhnethoxy)-quinolin-4- H yloxy]-phenyl}-oxalamide N*1 0 0 N-{3-Fluoro-4-[6-methoxy-7 (piperidin-4-ylmethoxy) 157 quinolin-4-yloxy]-pheny}-N (1S -phenyl-2-p-tolyl-ethyl)- H HN, oxalamide 51 WO 20051030140 PCTUS2004/031523 Table 1 Entry Name Structure N-[2-(4-Chloro-pheny1) ethy1]-N'-{3-fluoro-4-[6-0 158 methoxy-7-(piperidin-4- N ylnethoxy)-quinolin-4- H HN yloxy]-phenyl}-oxalamide Cl N-{3-Fluoro-4-[6-methoxy-7- F 159 (1-methyl-piperidin4 ylmethoxy)-quinolin-4- O yloxy]-phenyl }-oxalamic acid N A H OH

N

0 0 F N-{3-Fluoro-4[6-methoxy-7 (piperidin-4-ylmethoxy) 160 quinolin-4-yloxy]-phenyl}-' N N [2-(3-fiuom-phenyl)-ethyl]- H N HN oxalamide OF 0 N-[2-(2-Chloro-phenyl)- 0 9 ethyl-- 3-fluoro-4-[6-N 0 161 methoxy-7-(piperidin-4- N N N yhmethoxy)-quinolin-4- H H HN yloxy]-phenyl}-oxalamide 1 52 WO 2005/030140 PCT/US2004/031523 Table 1 Entry Name Strutue N-(3-Fluoro-4-[6-methoxy-7 (piperidin-4-ylmethoxy) 162 quinolin-4-yloxy]-phenyl}-N'- N N [2-(3-methoxy-phenyl)-ethyl]- H HN oxalamide '1N 0 O F N-(1,2-Diphenyl-ethyl)-N'-{3- 0 0 fluoro-4-[6-methoxy-7- N 163 (piperidin-4-ybnethoxy)- N N N quinolin-4-yloxy]-phenyll- H H HN oxalamide N-[2-(2,4-Dichloro-phenyl)- IO ethyl]-N'-{3-fluoro-4-[6- I 164 methoxy-7-(piperidin-4- N ylmthoxy)-quinolin-4- HHN yloxy]-phenyl}-oxalamide N-[2-(3,4-Dimethoxy- N phenyl)-ethyl]-N'-{3-fluoro-4 165 [6-methoxy-7-(piperidin- H H ylmethoxy)-quinolin-4-H yloxy]-phenyl)-oxalamide 53 WO 20051030140 PCTUS2004103 1523 Table 1 Entry NameStuur N-42-4EtyIpheny)-efiyl 1 N 166 (piperidin-4-ylmethoxy)- H quinolin-4-yloxy)-phenyl}- H oxalamide N-[2-(4-Ethoxy-phenyl)-00 ethyl)-N-{3-flucro4-[6- N d-~ ~ 167 niethoxy-7-(pipeidin-4- H II yhnethoxy)-quinolin-4- H yloxy)-phanyl}--oxalamide N-[2-(4-Ethoxy-3-methoxy- N ~ N 168 [6-methoxy-7-(piperidin-4- H r ylmethoxy)-quino~n-4- H yloxyl-phenyl)-oxalaraide 54 WO 2005/030140 PCT/US2004/031523 Table 1 Entry Name Structure N-{3-Fluoro-4-[6-methoxy-7- 0 (piperidin-4-ylmethoxy)- 0 169 quinolin-4-yloxy]-pheny1}j-N- N NI./ O [2-(4-phenoxy-phenyl)-ethyl]- H NH oxalamide 0 N N-(2-(3-Ethoxy-4-methoxy- 0 phenyl)-ethy1]-N'-{3-fluoro-4-N 170 [6-metoxy-7-(piperidin-4 ylmethoxy)-quinolin-4-. HN yloxy]-phenyl}-oxalamide N-f3-Fluoro-4-[6-methoxy-7 (pipetidin4-ylmethoxy)- 0 171 quinolin4yloxy-phenyl}-N'- N N C NN (2-pyrcidin-2-yl-ethiyl).. H H HN oxalamide

N

0 N-{3-Fluoro-4-[6-methoxy-7 (piperidin-4-ylmethoxy) 172 quinolin-4-yloxyj-phenyl }-N' - A (2-pyridin-4-yl-ethyl)- HN oxalamide N 55 WO 2005/030140 PCT/US2004/031523 Table 1 Entry Name Stcture N-{3-Fluoro-4-[6-methoxy-7- F (piperidin-4-ylmethoxy) 173 quinolin-4-yloxy]-phenyl}-N'- N [2-(4-fluoro-phenyl)-ethyl]- H HN oxalamide F N-[2-(2-Bromo-phenyl) , ethyl]-N'-{3-fluoro-4-6- ( 174 methoxy-7-(piperidin-4- N N O ylmethoxy)-quinolin-4- H H HN yloxy]-phenyl}-oxalamide Br 0 F N-[2-(2-Chloro-6-fluoro- 0 phenyl)-ethyl)-N'-{3-fluoro-4- N 175 [6-metboxy-7-(piperidin-4- N N ybnethoxy)-quinolin-4 HH H yloxy]-phenyl}-oxalamide F FF 0 N-{3-Pluoro-4-[6-methoxy-7- N 0 176 (piperidin-4-ylmethoxy)- N N quinolin-4-yloxy]-phenyl)-N- H H ' (2R-phenyl-propyl)-oxalamIide HN 56 WO 2005/030140 PCT/US2004/031523 Table 1 Entry Name Structure F N-f3-Fluoro-4-[6-methoxy-7- t0N 177 (piperidin-4-ylmethoxy)- N quinolin-4-yloxy]-phenyl1-N'- H indan-1-yl-oxalamide HN N-{3-Fluoro-4-[6-methoxy-7- F (1-methyl-piperidin-4- 0 178 ylmethoxy)-quinolin-4 yloxy]-phenyl)-N'-isobutyl- N N N oxalamide H HN 0 N-f 3-Fluoro-4-[6-methoxy-7 (1-methyl-pipmidin-4- Its 179 ylmethoxy)-quinolin-4- N N o yloxy]-pheny1}-N'-(3-methy1- N HN butyl)-oxalamide HN 0 N-{3-Fluoro-4-[6-methoxy-7- 0 F (1-methyl-piperidin-4- N 180 ylmethoxy)-quinolin-4- N NA/ N yloxy]-phenyl}--N'-(2R- HN phenyl-propyl)-oxalmide 57 WO 2005/030140 PCT/US2004/031523 Table 1 Entry ,NameSrute O5 q N-{3-Fluoro-4-[6-methoxy-7 (1-methyl-piperidin-4 181 ylmethoxy)-quinolin-4- N N yloxy]-phenyl)-N'-(2-phenyl- HN propyl)-oxalamide N-{3-Fluoro4-[6-methoxy-7- r F (1-methyl-piperidin-4- b 182 ylmcthoxy)-quinolin-4- N N NH O yloxy]-phenylj-N'-indan-2-y1- H oxalamide NH IN N-{3-Fluoro-4-[6-methoxy-7- F 183 (piperidin-4-ylmethoxy) quiolin-4-yloxy]-phenyl.-N- N O (1R-phenyl-ethyl)-oxalamide N 0 N-{3-Fluoro-4-[6-methoxy-7- F 184 (pipeidin-4-ylmethoxy)- O quinolin-4-yloxy]-pheny1}-N'~ N / (1S-phenyl-ethyl)-oxalamide N 58 WO 2005/030140 PCT/US2004/031523 Table 1 Entry Name Structure *O 0 N-[2-(3-]Bromo-phenyl)-0 ethyl]-N'-{3-fluoro-4-[6- ' 185 methoxy-7-(pipei-4- -N N t N y ylmethoxy)-quinolin-4- H NH yloxy]-phenyl}-oxalamide F N-(2-(2,6-Dichloro-phenyl)- O ethyl]-N'-{3-flnoro-4-[6- I 186 methoxy-7-(piperidin-4- N N O ylmethoxy)-quinolin-4- H H NH yloxy}-phonyll-oxalamide I CI F N-[2-(2,4-Dichloro-phenyl) ethyl]-N'-{3-flnoro4-[6 187 methoxy-7-(piperidin-4- N N O yhnethoxy)-quinolin-4- HH NH yloxy]-phenyl)-oxalamide CI N O F N-(2-Benzo[1,3jdioxol-5-yl ethyl)-N'-{3-fluoro-4-{6 188 methoxy-7-(piperidin-4- N ylmethoxy)-quinolin-4- H H NH yloxy}-phenyl}-oxalamide 50 59 WO 2005/030140 PCT/US2004/031523 Table 1 Entry Name Structure

N

0 N F N-[2-(3-Bromo-4-methoxy-0 pheyl)ethl]-'-3-fluoro-4 phnl)hylN]3M uw 6 N~ & 189 [6-methoxy-7-(piperidin-4- N NN o ylmethoxy)-inoln-4. H H NH yloxy]-phenyl}-oxalamide F N-[2-(3,5-Dimethoxy- t phenyl)-ethy]-N'-{3-fluaro-4- N N N 190 [6-methoxy-7-(piperidin-4- H H ylmethoxy)-quinolin-4- NH yioxy]-phenyl}-oxalamide NO 0 F N-{3-Fuoro-4-f6-methoxy-7- 0 11 (piperidin-4-ylmethoxy)-N quinolin-4-yloxy}-pheny}-N'- N N'yO (2-o-tolyl-ethyl)-oxalamide NH 60 WO 2005/030140 PCT/US2004/031523 Table 1 Entry Name Structure N1* 0 N-f3-Fluoro-4-[6-methoxy-7- 5 192 (piperidin-4-ylmethoxy)- N quinolin-4-yloxy]-phenyl)-N'- H NH (2-m-tolyl-ethyl)-oxalamide O N-[2-(3-Ethoxy-pheny)- 0 ethyl]-N'-{3-fluom-4-[6 193 methoxy-7-(piperidin-4- N yhnethoxy)-quinolin-4- H NH yloxy]-phenyl}-oxalamide O F~ N-[2-(3,4-Dimethyl-pheny)- c ethyl]-N'-f3-fluoro-4-16 194 methoxy-7-(piperidin-4- N N& N ylmethoxy)-quinolin-4- H NH yloxy]-phenyl}-oxalamide N Ao NO 0 N-[2-(2,5-Dimethyl-phenyl)- o ethyl]-N'-{3-fluoro-4-[6 195 methoxy-7-(piperidin-4- N ./ N ylmethoxy)-quinolin-4- H NH yloxy]-phenyl}-oxalamide 61 WO 2005/030140 PCT/US2004/031523 Table 1 Entry Name Strucure N-[2-(3-Chloro-4-propoxy- O1 r phenyl)-ethyl]-N'-{ 3-fluoro4 I I 196 [6-methoxy-7-(piperidin4- N N O ylmethoxy)-quinolin-4- H NH yloxy]-phenyl}-oxalamide Cl 0 N-(2-(4-Butoxy-3-chloro- O phenyl)-ethyl]-N'-{3-fluoro-4- 4in N 197 [6-methoxy-7-(piperidin-4- H N N O ylmethoxy)-quinolin-4- H NH yloxy]-phenyl}-oxalamide Cl N-[2-(4-tet-Butyl-phenyl)- 1 ethyl]-N.'-{3-fluoro-446- N 198 methoxy-7-(piperidin-4- H NH ynethoxy)-quinolin-4 yloxy]-phenyl}-oxalamide 62 WO 2005/030140 PCTUS2004/031523 Table 1 Entry Name Structure N-{3-Fluoro-4-[6-methoxy-7- 0 (piperidin-4-ylmethoxy)- N 199 quinolin-4-yloxy]-phenyl}-N'- N [2-(4-sulfamoyl-phenyl)- NH etbyfl-oxalamide;t

H

2 N% N-f 3-Fluoro-4-[6-methoxy-7 (piperidin-4-ylmethoxy) 200 quinolin-4-yloxy}-phenyl}-N'- N N N O [2-(4-hydroxy-3-methoxy H NH phenyl)-ethyl]-oxalamide HO 0 N-{ 3-Fuoro-4-[6-methoxy-7- 0 (piperidin-4-ylmethoxy) 201 quinolin-4-yloxy]-phenyl}-N'- N N' [2-(3.-hydroxy-4-methoxy- H H NH phenyl)-ethyl]-oxalamide H HO 63 WO 2005/030140 PCTUS2004/03152 3 Table 1 Entry Name Structure NO N-(2,4-Dichloro-benzyl)-N'- 3 {3-fluoro-4-[6-methoxy-7- N N 202 (piperidin-4-yhnethoxy)- H quinolin-4-yloxy]-phenyll- NH oxalamide C1 C1 F N-{3-Fluoro-4-[6-methoxy-7- 0 (piperidin-4-ylmethoxy)- N N N' O 203 quoin-4-yloxy]-phenylj-N'- H NH (4-fluoro-2-trifluoromethyl- F benzyl)-oxalamide F F4 X 0F N-{3-Fluoro-4-[6-methoxy-7- 0 j0 204 (piperidin-4ylmethoxy) quinolin-4-yoxy]-phenyl}-N- NH (1-p-tolyl-ethyl)-oxalamide 64 WO 2005/030140 PCT/US2004/031523 Table 1 Entry Name Structure 0F N-{3-Fluoro-4-[6-methoxy-7- s (piperidin-4-ylmethoxy)- N 205 quinoin4-yloxy]-phenyJ}N'- H NH (3-fluoro-4-tdfluoromethyl benzyl)-oxalamide F CFs 0 F N-(3-Chloro-4-fluoro-benzyl)-0 N-{3-fluoro-4-[6-methoxy-7- N N 206 (piperidin-4-ylmethoxy)- N quinolin-4-yloxy]-phenyl} oxalamide CI F N-{3-Fluoro-4-[6-methoxy-7- O 5 (piperidin-4-ylmethoxy) 207 quinolin4-yloxy]-phenyl}-N'- N N [1-(3-methoxy-pheny1)-ethyl]- H NH oxalamide 65 WO 2005/030140 PCT/US2004/031523 Table 1 Entry Name Structure N-{3-Fluoro-4-[6-methoxy-7- 8 (pipeddin-4-ylmethoxy)- N O 208 quinolin-4-yloxy)-phenyl}-N'- NH (1-naphthalen-2-yl-ethyl) oxalamide "0 F N-(4-Chloro-3-00 tifluorormethy1-benzyl)-N'- I {3-fluoro4-[6-methoxy-7- N N 209 (piperidin-4-ylmethoxy)- H HlNH quinolin-4-yloxy]-phenyl} oxalamide Ps3C 0.

8 CI 0 F0 N-{3-Fluoro-4-[6-methoxy-7- 1 0 210 (pipeddin-4-ykmethoxy)- N quinolin-4-yloxy]-phenyl}-N- H NH (1-p-tolyl-othyl)-oxalamide 66 WO 2005/030140 PCT/US2004/031523 Table 1 Entry Name Structure N F N-{3-Fluoro-4-[6-methoxy-7- 0 (piperidin-4-ylmeothoxy)- N N0 211 quinolin-4-yloxy]-phenyl}-N'- , NH (6-trifluoromethyl-pyridin-3 ylmethyl)-oxalamide

CF

3 N F N-{3-Fluoro-4-[6-methoxy-7- 0 212 (piperidin-4-ylmothoxy)- N N O quinolin4-yloxy]-phenyl}-N'- H (2-mcthyl-benzyl)-oxalamide t NH F N-{3-Fluoro-4-[6-mothoxy-7- 0 213 (piperidin-4-ylmethoxy)- N NN N quinolin-4-yloxy]-phenyl}-N' (3-methyl-benzyl)-oxalamide HNH 67 WO 2005/030140 PCTr/US2004I031523 Table I Entry NameStuur N(3-Huorotf6-methoxy-7- 0 ~ A 214 quinolinA-yioxy]-phenyl } -N!- H 4 (4-f luoro-3-trifluorometbyl benzyl)-oxalamide N-(3,5-Diohloro-benzyl)-N'-0 f 3-fluoro-4-[6-znethoxy-7-I 215 (piperidin-4-ybnethoxy)- 6 N q y y y } N H oxalamide N-{ 3-FI'uoro-4-[6-methoxy-7- 0 26 (piperdin-4-yhnethoxy)- K) N1 26 quinolIn-4-yloxy]-phenyl}-N' (1R,2,3,4-tetrohydro- N naphthalen-1-yl)-oxalaxnide N -{3-Fluoro-4-[6-methoxy-7- 0>o..S 27 (piperidin-4-ylmethoxy)- K) NAy 27 quinoIfn-4-yloxyj-phenyl} -N'- 0 (18,2,3,4-tetrahydro- .NH naphtbalea-1-yI)-oxalamide 68 WO 2005/030140 PCTUS2OD4/031523 Table 1 Entry Name Structure N-Cyclopentyl-N'-{3-fluaro- y"F 218 44[6-xnothoxy-7-(piperidin-4- 0 ylmethoxy)-quinotin-4- .6N 10 yloxy]-phenyl}-oxalamide H NH' N.{1-(4-Bromo-phenyl)> 05 219 methoxy-7.-(piperidin-4- H NH ylmethoxy)-quinolin-4- N yloxy]-phenyl}-oxalmide Br N-(2-Fl-uoro-benizyl)-N'-{ 3- 0 % n~ fluoro-4-[6-methoxy-7- K 220 (piperidin-4-ybnethoxy)- N & ry quinolin-4.-yloxy]-phenyl}- H NH oxalamide F N-[2-(3,4-Dichloro-phenyl)- N ethyl]-N'-{3-fluro-4-16- ,I)Y 221 methoxy-7-(pipericlin-4-N yfinethoxy)-quinolin-4- H NH yloxy]-phenylj -oxalanide CI C1 69 WO 2005/030140 PCTUSOO4IO3X52S Table I N-(4-fluoro-benzyl)-W-{3- 0 0 fluoro-4-(6-methoxy-7- N) Nr 222 (pipcuidin-4-yhnethoxy)- NH quiniolin-4-yloxy]-phenyfl ~N N 223 (piperidin-4-ylnaethoxy)- N quinolin-4-yloxyll-phenylj- HNH oxalanide F 225 (pipedrdin-4-ymethoxy)- NloI4[-mtoy7 7A:o quinoin4-yloxy]-phenyl)-- H N (2peox-tloaiide N 700 WO 2005/030140 PCTfU52004/031523 Table 1 Entry Name Structure Nq134Fluoro-4[6meffioxy-7- 0S' ~y 226 quinolin-4-yloxy]-phenyl}-N'- -, [2-(4-methoxy-phenyl)-ethyl]- NH oxalamide N-{3-fluo-ro-4-16-methoxy-7- 221 (piperidin-4-ylmethoxy)- K)N (2-phenyl-propyl)-oxalanidNH F 228 meth oox- -pedn-4- KS0 Y0y Nt--(-om o-enyl)1 22 ethy-'-3-flurod-4- N 0 ylmethcrxy)-quinolin-4- riNH yloxy]-pheutyi)-oxalamide B0 F N-{4-[7-(i-Etbyl-piperidin-4- 0 ylniofxy)-6-methoxy- K 29 quinolin-4-yloxy-3-fluoro- NN-Y phenyl}-2-oxo-2-(2-phenyl- KN morpholin-4-yI)-acetamide N ) 71 WO 2005/030140 PCT/US2004031523 Table 1 Entry Name Structure 0 F N-{ 3-Fluoro4-[6-methoxy-7 (piperidin-4-ylmethoxy) 230 quinolin-4-yloxy]-phenyl}-N' (3-fluoro-5-trifluoromethyl- NH benzyl)-oxalamide FaC F 0 O F N-(3,5-Dif2uoo-benzyl)-N'- A {3-fluoro4[6-methoxy-7- N 01 , 231 (piperidin-4-ylmethoxy)- N quinolin-4-yloxy]-phenyl)- H NH oxalamide F F 0 O F N-(2-Chloro5- ' trifluoromethyl-benzyl)-N' 232 {3-fluoro-4-[6-methoxy-7- N N ON (piperidin-4-ylmethoxy)- H NH quinolin-4-yloxy]-phenyl) oxalamide ci F s O F N-[4-(6,7-Dimethoxy- ON/ O quinolin4-yloxy)-3-fluoro- N A N O 233 phenyl]-N'-(2-dimethylamino- NH 2-phenyl-ethyl)-oxalamide 72_ $1 K 72 WO 20051030140 PCTIJSZOO4/031523 Table 1 Entry Name tcm N-{3-Tuoro4[6-niethoxy-7-0 (piperidin-4--yhnethoxy) 234 quinolin-4-yloxy]-phenyl}-N'- NHY (4-methoxy-benzyl)- N oxalamido N-{3-Ftuoro-4-[6-methoxy-7 (piperidin-4-ylmethoxy)- N 25 quinolrn-4-yloxy]-phenyl}-N- NH (4-trffuoromediyl-benzyl)- N

CF

3 N-f3-iFluoro-4-[6-methoxy-7- 0X (pipeildiu4-yhnethoxy) 236 quinolin4yloxy-phenyl)-N*'- , (3-methoxy-benzyl). NH axaaide 73 WO 2005/030140 PCT/US2004/031523 Table 1 Entry Name Structure 0 F N-{3-Fluoro-4-[6-methoxy-7 (piperidin-4-ybmethoxy)- N 237 quinolin-4-yloxy]-pheny}-N (3-trifluoromethy1 benzyl)- H oxalaniide FsC F N-{3-Fluoro-4-[6-methoxy-7 (piperidin-4-ylmethoxy) 238 quinolin-4-yloxy]-phenyl)-N'- N (3-trifluoromthoxy-benzy)- NH oxalamide - F N-{3-Fluoro-4-[6-methoxy-7- 0 (piperidin-4-ymethoxy)- NI r 239 quinolin-4-yloxyj-phenyl}-N'- - NNN O (2-methoxy-benzyl)- H NH oxalamide N-{3-Fluoro-4-[6-methoxy-7- 6 0 (piperidin-4-ylmethoxy) 240 quinolin-4-yloxy]-phenyl}-N'- N N / (2-trfluoromethyl-benzyl)- H NH oxalamide 74 WO 2005/030140 PCT/US2004/031523 Table 1 Entry Name Structure 0 F N-(3-Chloro-benzyl)-N'-{3- 0 fluoro4-[6-methoxy-7- N 241 (piperidin-4-ylmethoxy)- N quinolin4-yloxy]-phenyl}- NH oxalamide Cl N-f 3-Fluoro-4-[6-methoxy-7- 0 O (piperidin-4-ylmethoxy)- ) 1 K 242 quinolin-4-yloxyl-phenyl}-N'- N (2-trifluoromethoxy-benzyl)- NH oxalamide ,FsC' ~~o3 O F N-(2-Chlaco-benzyl)-N'-{3-0 0 fluoro-4-[6-metoxy-7 243 (piperidin-4-ylmethoxy)- NN quinolin-4-yloxyj-phenyl}- H NH oxalanil7 15 WO 20051030140 PCT/US2004/031Z3 Table 1 Entry Name Structure 0 N-f 3-Fluoro-4-[6-methoxy-7- 0 (piperidin-4-ylmethoxy)- N:kNY O 244 quinolin-4-yloxyj-pheny1}-N'- HH NH (4-trifluoromethoxy-benzyl) oxalamide 0 F N-{3-Flboro-4-[6-methoxy-7- 0 (1-methyl-piperidin-4- N N NY 245 ylmethoxy)-quinolin-4- I NH yloxy]-pheny1}-N'-(4 methoxy-benzyl)-oxalamide N-{3-Fluoro-4-[6-methoxy-7- (5 0N (1-methyl-piperidin-4-N 246 ylmethoxy)-quinolin-4- N yloxy]-phenyl}-N'-(4- NH trifluoromethyl-benzyl) oxalamide OF7 76 WO 2005/030 140 PCTJUS2004/031523 Table 1 Entry Name Structure 'N.0 N-f 4-[7-(Azetidin-3- A0 ylmethoxy)-6-methoxy- S 247 quinoi-4-yloxy]-3-fiuoro- H phnl}N-phenethyl- NH oxalamide N-{3-Fluoro-4-f6-methoxy-7- Ao (1-methyl-azetidin-3-N N 248 ylmetboxy)-quinolin-4-N N0 yloxy]-phenyl}-N'-phenethyl- NH oxalamide r N F N-{3-Fluoro4-[6-methoxy-7- 0~ 1 N (pipezidin-4-ylmethoxy)-N .29 quinolin-4-yloxyJ-pbeny1J-Nt. N II (2-hydroxy-2-phenyl-ethyl)- H NH oxalamide 01 1OH 0 0' N N-f 5-Chloro-6-(6,7- N 250 dimethoxy-quinolin-4-yloyxy)- N 0Nt pyxIdin-3-yl]-N'-(2,4-difluoro- H phenyl)-malonamide WO 2005/03 0140 PCT1US2004/031523 Table 1 N- [5-Chloro-6-(6,7- 0 dimthoxy-quiolIn-4-ylox-y)- N x N 2.51 pyridin-3-yl]-N-(4-fluoro- HA phenyl)-N'-methyl-N 0 malonamide F N-{3-Bluoro-4-[6-znethoxy-7- 0 (piperidi-4-ylmethoxy)- 0 252 q~oi--~x]peyjN N 0 (IR-phenyl-propyl)- H N oxalamide N-{3-fluoro-4-[6methoxy-7- 0 23 (piperidin-4-yhnethoxy)- L) 4o 0 23quinolin-4-yloxy]-phenylj-N' (IR-phenyl-propyl)- NH oxalamide 78 WO 2005/030140 PCT/US2004/031523 Table 1 Entry Name Structure N-(3,4-Difluoro-benzyl)-N'- 0 0 (3-fluoro-4-t0-methoxy-7- N 254 (piperidin-4-yhnethoxy)- H NH quinolin-4-yloxy]-phenyl NH oxalamide F F 0 - F N-(2,6-Difluoro-benzy)-N'- O {3-fluoro-4-[6-methoxy-7- ( 4 255 (piperidin-4-ylmethoxy)- N NN O quinolin-4-yloxy]-phonyl}- H H NH oxalamide F N-{ 3-Fluoro-4-[6-methoxy-7 (1-methyl-piperidin-4-0 256 ylrnethoxy)-quinolln-4- OIt yloxy]-phenyl}-N'-[2-(4- NH fluoro-phenyl)-ethyl]- NH oxalamide .FN N-{3-Fluoro-4-[6-methoxy-7- 0 F (1-methyl-piperidin-4- 0 257 ylmethoxy)-quinolin-4- I) N yloxy]-phenyl}-N'-phenyl- N oxalamide NH 09 79 WO 2005/030140 PCT/US2004/031523 Table 1 Entry Name Structure O F N-{3-Fluoro-4[6-methoxy-7- 5 258 (piperidin-4-yhnethoxy) quinolin4-yloxy]-pheny}-N' (3-fluoro-phenyl)-oxalamide NH ~~0 F N-(4-Cbloro-3-fluoro- I5 N phenyl)-N'- 3-fluoro-4-[6 259 methoxy-7-(piperidin-4- N N O ylmethoxy)-quinoln-4- H NH yloxy]-phenyl}-oxalamide F 1.0 N-(3,4-Dimethoxy-pheny1)- 0 F N'-{3-fluoro-4-[6-methoxy-7 260 (piperidin-4-ylmethoxy)- [ N quinolin-4-yloxy]-phenyl}- H H oxalamide Io NH N-{3-]Fluoro-4-[6-methoxy-7- 0 261 (piperidin-4-ylmethoxy) 21 quinoli-4-yloxy]-phenyI}-N'- N (3-methyl-butyl)-oxalamide NH 80 WO 2005/030140 PCT/US2004/031523 Table 1 Entry Name Structure O N-(3,3-Dimethyl-buty1)-N- 1 -r {3-fluoro-4-[6-methoxy-7- I 262 (piperidin-4-ylmethoxy)- N N quinolin-4-yloxy]-phenyl}- H NH oxalamide ~~0 rN CI N-{5-Chloro-&[6-methoxy-7- > iN 0 (3-piperidin-1-yl-propoxy)- N N N, 263 quinolin-4-yloxyl-pyridin-3- H yl}-N'-(4-fluoro-phenyI)- HN O malonamide F N-{5-Chloro-6-[6-methoxy-7- 0 (3-morpholin-4-yl-propoxy)- NN N N 264 quinoln-4-yloxy]-pyridin-3- H y1}-N'-(4-fluoro-phenyl)- HN 0 malonamide 81 WO 2005/030140 PCT/US2004/031523 Table 1 Entry Name Structure CI N-{5-Chloro-6-[7-(3 diethylanno-propoxy)-6- N N N N 265 methoxy-quinolin-4-yloxy]- H pyridin-3-yl}-N'-(4-fluoro- HN phonyl)-malonamide F 0 10 F N-(4-Chloro-benzyl)-N'-{3- 0 fluoro-4-[6-methoxy-7- N 266 (piperidin-4-ylmethoxy)- NH quinolin-4-yloxy]-phenyl} oxalanide CI OINF N-(3,5-Dimethoxy-benzyl)- 0 N'-{3-fluoro-4-[6-methoxy-7- N NX/ N O 267 (piperidin-4-ylmethoxy)- H NH quinolin-4-yloxy]-phenyl} oxdamide 0O 82 WO 2005/030140 PCT/US2004/031523 Table 1 Entry Name Structure N-(4-Butyl-benzyI)-N'-{3- /0 fluoro-4-[6-methoxy-7- N 268 (piperidin4-ymethoxy)- NH quinolin-4-yloxy}-phenyl} oxalamide 0 N-{3-Fluoro-4-[6-methoxy-7- 4/ (piperidin4-ylmethoxy)- N O quinolin-4-yloxy]-phenyl}-N'- NH (2-p-tolyl-ethyl)-oxalamide NH :N F N-(3,5-Bis-tifluoromethyl- o benzyl)-N'-{3-fluoro-4-[6- N O 270 methoxy-7-(piperidin-4- N N--Y yhnethoxy)-qninolin-4- H NH yloxy]-phenyl}-oxalamide

F

3 0 CF 3 83 WO 2005/030140 PCTUSZOO04/031523 Table I. Entry Name Structure 'o I~kF N-{3-1luoro4-[6-raethoxy-7- 0 21 quinioUm.4qyoxy)-phenyl N'.. H Y pyrazin-2-yhnethyl-oxalamide NH ~0 F 272 (piperklin-4-ylmethoxy)- N'0 qunolin-4-yloxy]-pbenyl}I-NI- NNHy pyridin-2-ylmethyl-oxalainide 6 N-{3-Fluoro-4-116-methoxy-7- 0 23 (piperidin-4-y~methoxy)- N N 23 qtunain -4-yloxyj-phenyl}- H -Y N'-phenethyl-oxalamide NH N-(3-Fluoro-4-[6-methoxy-7-0 (1-methyl-piperidin-4 274 ylmethoxy)-qninazolin-4 yloxy]-phenyl}-N t -phenethyl- I 84 WO 2005/030140 PCT/US2004/031523 Table 1 Entry Name Structure F N-{3-Fluoro-4-[6-methoxy-7 (piperidin-4-ylmethoxy) 275 quinolin-L4-yloxy]-phenyl}-N'- N O (2-fluoro-3-trifuoromethyl- NH benzyl)-oxalamide FaC N-[2-(2-Bromo-6-methoxy- 0 phenyl)-ethyl]-N'-{3-fluoro-4- K 276 [6-methoxy-7-(piperidin-4- N ylmethoxy)-quinolin-4- NH yloxy]-phenyl}-oxalamide Br N-[2-(3,4-Dimethoxy phenyl)..ethyl]-N'-{3-fuoro-4.

277 [6-methoxy-7-(piperidin-4- N 0 ylmethoxy)-quinolin-4- HH yloxy)-phenyl1-N-methyl oxalamide N% 0 0 F N-[2-(5-Bromo-2-methoxy pheny1)-ethyl]-N'-{3-fluoro-4- NZ 0 278 [6-methoxy-7-(piperidin-4 ylmethoxy)-quinolin-4- NH yloxy)-phenyl)-oxalamide Br 85 WO 2005/030140 PCT[7U520041031523 Table 1 Entry Name Srcw 0S Nk N-f -FluoroA-6-xnethoxy-7-00 (piperfdin-4-ylmetboxy)-N 279 quinolio4-yloxy]-phenylj-N'- NHY (2-fluoro-5-trifluoromethyl- M benzyl)-oxalamide CF3 N-f 3-Fiuoro-4-(6-methoxy-7 (piperxidin-4-ylmcthoxy)- N1 280 quinoliu-4-yloxyj-phenyl }-N- NH [1-(4-tluoro-phenyl)-ethytl F N-(IS-Benzyl-2-oxo-2- 0 pyrroijdn--y-ethy)-N-f 3- 0 281 fluoo-46m thoxt(5 0N ~ ~ 00 quinolin-4-yloxyl-phenytl HN-, N-f 3-Pluoro-4-[6-naetboxy-7- 1.~ .

0 o.&~> (octahydro 282 cyclopenta[cjpyirol-5- H HN, ,NN y ylmethoxy)-quinazolin-4-H yloxyj-phenyl)-N'-phonethyl- NN oxabmiide 86 WO 2005/030140 PCTIUS2004/031523 Table 1 Entry Nam Structure 0 F N-[2-(4-Amino-phenyl)- N ethyl]-N'-{3-fluoro-4-[6- N I 283 methoxy-7-(piperidin-4 ylmethoxy)-quinolin-4- NH yloxy]-phenyl}-oxalamide

H

2 N 0 O' F 2-(4-Bfenzyl-piperidin-1-yl)- I>'Y N N-{3-fluoro-4-[6-methoxy-7- N N 284 (piperidin-4-ylmethoxy)- H N quinolin-4-yloxy]-phenyl}-2 oxo-acetamide N-[4-(6,7-Dimethoxy- N / Z 285 quinolin-4-yloxy)-phenyl]-N- H (4-fluoro-phenyl)-malonamide F 87 WO 2005/030140 PCT/US2004/031523 Table 1 Entry Name Structure 0 N-[5-Chloro-6-(6,7- 0 286 dimethoxy-quinolin-4-yloxy)- N N pyridin-3-yI]-N'-(3-fluoro phenyl)-malonamide HN 0 F -CC N-[5-Chloro-6-(6,7- O 287 dimethoxy-quinolin-4-yloxy)- N N pyridin-3-yl)-N'-phenyl-' malonamide N 0 *~0 A C N-[5-Cbloro-6-(6,7- 0 dimethoxy-quinolin-4-yloxy)- N N N 288 pyridin-3-yIj-N'-(4-fluoro- H phenyl)-2,2-dimethyl- HN malonamide F N-Ethyl-N'-{3-fluoro-4-[6 289 methoxy--(piperidi-n-0 ylmethoxy)-quinolin-4- NO yloxy}-phenyl}-oxalamide NH 88 WO 2005/030140 PCT/US2004/031523 Table 1 Entry Name Structure N-{3-Fluoro-4-[6-methoxy-7- F 290 (piperidiN-4-ybmthoxy)- O quinoliln-4-yloxy]-phenyl 1-Nw- NKol&)r isopropyl-oxalamide N-Butyl-N'-{3-fluoro-4-[6- F 291 methoxy-7-(piperidin-4- O ylmethoxy)-quinoin-4 yloxy]-phenyl)-oxalamide N O H NH N-{3-Fluoro-4-[6-methoxy-7- O F 293 (piperidin-4-ylmethoxy)- 00 quinolin-4-yloxy]-phenyl}-N (2-methoxy-etiyl)-oxaamid N 0'(0 '*-- NH 0 N-Cyclopropylmethyl-N'-{3- F fluoro-4-[6-mthoxy-7- 0 293 (piperidin-4-ylmethoxy)- N quinolin-4-yloxy]-phenyl}- H oxalamide 8.9 N-{3-Fluoro-4-[6-methoxy-7- F (piperidin-4-yhnethoxy)- ' 294 quinolin-4-yloxy]-phenyl}-N'- N o (2-morpholin-4-yl-ethyl)- N oxaamide -N N-o NH 89 WO 2005/030140 PCT/US2004/031523 Table 1 Entry Name Strcure N-f 3-Fluoro-46-methoxy-7- F (piperidin4-ylmethoxy)- 0 295 quinolin-4-yloxy]-phenyl}-2 oxo-2-pyrrolidin-1-yl- N N-'O acutamideN N-Ethyl-N'-{3-fluoro-4-[6- F methoxy-7-(piperidin-4- O 296 ylmethoxy)-quinolin-4- N yloxy]-phenyl}-N-methyl-N/O oxalamide (0078] In another aspect, the invention comprises a compound for modulating kinase activity of formula A-B-C, or a pharmaceutically acceptable salt, hydrate, or prodrug thereof, wherein, A is selected from:

-RR

00-2

R

1 R R}O -2 RtNN

N

8 R 90 WO 2005/030140 PCT/US2004/031 5 23 RA / M- RO N 1 N-R-OR N / oR-o B is selected from 0 N 8(0)-a 0 -.. I 1- R 8 1 N NA N N(ONol \ 3 -3 I 0 ,,I (RR N()- S0(-20 h 0 -3 91 WO 2005/030140 PCT/US2004/031523

E

1 E1 03 1-2 0-3 0- 0 ~l 2 0

(R

2 )q RS q 0-2 q(R 2 ) 0 N

-

El ElR (RERS q(F2) o q(R2) s 0 \ 1F1 5

R

5 0 RS R35 R 5 A2 Ra A rr 3 (R%) (R2 wherein R 2 is selected from -H, halogen, trihalomethyl, -CN, -NH 2 , -NO 2 , -OR', -NR 3 , -S(0)-2R 3 , -SO 2

NR

3 W, -C0 2

R

3 , -C(O)NR 3

R

3 , -N(R 3

)SO

2 R, -N(R 3

)C(O)R

3 ,

-N(R

3

)CO

2

R

3 , -C(O)R 3 , and optionally substituted lower alkyl; q is 0 to 2; each R 3 is independently selected from -H, optionally substituted lower alkyl, optionally substituted aryl, optionally substituted arylalkyl, and optionally substituted heteroarylalkyl; two R3, together with the nitrogen to which they are attached, form a four- to seven membered heteroalicyclic, said four- to seven-membered heteroalicyclic optionally containing one additional heteroatom; when one said additional heteroatom is a nitrogen, then said nitrogen is optionally substituted with a group selected from -H, trihalomethyl,

-SO

2 R, -SO 2

NR

5

R

5 , -CO 2

R

5 , -C(O)NR 5 R, -C(O)R 5 , and optionally substituted lower alkyl; each R' is independently selected from -H, -C(=O)R 3 , -C(=0)OR, -C(=O)SR 3 , -S0 2

R

3 , -C(=0)N(R 3

)R

3 , and optionally substituted lower alkyl; 92 WO 2005/030140 PCT/US2004/031523 two RO, together with the nitrogen to which they ate attached, can combine to fonm a heteroalicyclic optionally substituted with between one and four of R", said heteroalicyclic may have an additional annular heteroatom, and said heteroalicyclic may have an aryl fused thereto, said aryl optionally substituted with an additional one to four of

R;

A' is selected from =N-, =C(H)-, and =C(CN)-;

A

2 is either =N- or =C(H)-; R5 is -H or optionally substituted lower alkyl; R8 is selected from R3, -SO 2

NRR

3 , -CO2R 3 , -C(O)NR 3 R, -SOzR 3 , and -C(O)R 3 ; R', R 0 , and R" are each independently selected from -H, and -OR 12 ; or R9 is selected from -H, and -OR 1 E, and R'O and R", when taken together, are either an optionally substituted alkylidene or an oxo; and

P

2 is selected from -H, -C(O)R 3 , optionally substituted lower alkylidyne, optionally substituted lower arylalkylidyne, optionally substituted lower heterocyclylalkylidyne, optionally substituted lower alkylidene, optionally substituted lower alkylidenearyl, optionally substituted lower alkylideneheterocyclyl, optionally substituted lower alkyl, optionally substituted lower alkylaryl, optionally substituted aryl, optionally substituted lower heterocyclylalkyl, and optionally substituted heterocyclyl; or two R's, when taken together, form 1) a corresponding spirocyclic ketal when said two R 12 's stem from R"' and R", or 2) a corresponding cyclic ketal when said two R''s stem from R 9 and one of R 10 and R"; 1 is selected from -0-, -CH 2 -, -N(R)-, and -S(0)0-2-; Q is a five- to ten-membered ring system, optionally substituted with between zero and four of R 20 ; R2 is selected from -H, halogen, trihalomethyl, -CN, -NO2, -NH 2 , -OR', -NVR 3 , -S(O)o.2R 3 , -SO 2

NR

3 R, -CO2R 3 , -C(O)NR 3

R

3 , -N(R 3

)SO

2

R

3 , -N(R 3 )C(0)R',

-N(R

3

)CO

2

R

3 , -C(O)R 3 , and optionally substituted lower alkyl; R" is selected from -H, halogen, trihalomethyl, -CN, -NO 2 , -NH2, -OR 3 , -NR( 3 , -S(0)0.2R 3 , -SO 2 NR3R, -CO2R 3 , -C(o)NRIR, -N(R 3 )SO2R3, -N(R 3 )C(o)R 3 , 93 WO 2005/030140 PCT/U1S2004/031523

-N(R)CO

2

R

3 , -C(O)R 3 , optionally substituted lower alkyl, optionally substituted aryl, optionally substituted heteroarylalkyl, and optionally substituted arylalkyl; two of R6, when attached to a non-aromatic carbon, can be oxo; each methylene in any of the above formulae is independently optionally substituted with each R 2 5 is independently selected from halogen, tibalomethyl, -CN, -NO 2 , -NH 2 , -OR 3 ,

-NR

3

R

3 , -S(O)o-2R 3 , -SO,'RR 3 , -CO 2

R

3 , -C(O)NR 3 R', -N(R 3

)SO

2

R

3 , -N(R 3 )C(O)R,

-N(R

3

)CO

2

R

3 , -C(Q)R, optionally substituted aryl, optionally substituted arylalkyl, heteroarylalkyl, and optionally substituted lower alkyl; two of R 25 , together with the carbon or carbons to which they are attached, can combine to forit a three- to seven membered alicyclic or heteroalicyclic, two of RM on a single carbon can be oxo; with the proviso that when B is selected from: 1 O Nz A R3_ N and C contains (R,)q and the remaining portion of C contains one of: H H H H H Y"N O ', N YN NyN 0 SO H H NYS% S S 94 WO 2005/030140 PCT/US2004/0 3 15 23 directly attached to (R2)q , then A must be one of; 0 R N Nr-N

O

8 N2 and with the proviso that when C contains , and B is selected from: 1A 1 , A' 95-4 1-4A 0-2 RN - A'C RR09A ' N 4 9I5R WO 2005/030140 PCT/US2004/031523 then the portion of C directly attached to (R 2 q cannot contain 0 0 H R70 70, when R 7 0 is selected from -H, C 1 4alyl, and C 1 4 alkoxyl. [0079] In another example the compound is according to paragraph [0078], wherein Q is selected from phenyl, napthyl, 1,2,3,4-tetrahydronaphthyl, indanyl, benzodioxanyL benzofuranyl, phenazinyl, phenothiazinyl, phenoxazinyl, tetrahydroisoquinolyl, pyrrolyl, pyrazolyl, pyrazolidinyl, imidazolyl, imidazolinyl, imidazolidinyl, tetrahydropyridinyl, pyridiny], pyrazinyl, pyrimidinyl, pyridazinyl, oxazolyl, oxazolinyl, oxazolidinyl, triazolyl, isoxazolyl, isoxazolidinyl, thiazolyl, thiazolinyl, thiazolidinyl, isothiazoly], isothiazolidinyl, indolyl, isoindolyl, indolinyl, isoindolinyl, octahydroindolyl, octahydroisoindolyl, quinolyl, isoquinolyl, benzimidazolyl, thiadiazolyl, benzopyranyl, benzothiazolyl, benzoxazolyl, furyl, thienyl, benzothieliyl, and oxadiazolyl; each optionally substituted with between one and four of R; wherein each R is independently selected from -H, halogen, trihalomethyl, -CN, -NO 2 , -NH 2 , -OR 3 , -NRR, -CO2W, -C(O)NR 3

R

3 , -N(R 3

)SOR

3 , -N(R 3

)C(O)R

3 , -N(R 3

)CO

2

R

3 , -C(O)R 3 , and optionally substituted lower alkyl. [0080] In another example the compound is according to paragraph (0079], wherein B is either of the following: V N R/- N wherein A' is either =N- or =C(H)-. [00811 In another example the compound is according to paragraph [0080], wherein B is N 96 WO 2005/030140 PCT/US2004/031523 [0082] In another example the compound is according to paragraph [0081], wherein C is selected from: H R Al (R20).N R 2 R-52R H E N N NyN a 2 R 0-2 --(3~ E 0

R

2 R \ N Re0-

I(R)

3 N H R 0 0 2 00-2 t E- )0H 4 N c< N N ; 0 R 0 (R 6 o4 R2 R2 WO 2005/030140 PCT/US2004/031523 02 N N N 0(-0 R2 H~ 0- H0-2 N N wherein R2, R 3 , R(~ R 20 , R3M and R 60 are as defined above. [0083] In another example the compound is according to paragraph {0082], R2 is selected from halogen, trihalomethyl, -CN, -NO2, -QRl, -NR 3 , .- C0 2

R

3 , -C(O)NR 3

R

3 ,

-N(R

3

)C(Q)R

3 , -N(R 3

)CO

2

R

3 , -C(Q)R 3 , and optionally substituted lower alkyl [0084] In another example the compound is according to paragraph [0083], wherein R2 is halogen. [0085] In another example the compound is according to paragraph [0084], wherein R 2 5iS either fluorine or chlorine. [0086J In another aspect, the invention comprises a compound for modulating kinase activity according to Formula XI, 0(R) R0 (0)04 N RR3 XI or a pharmaceutically acceptable salt, hydrate, or podrug thereof, wherein, 98 WO 2005/030140 PCT/US2004/031523 each RI is independently selected from halogen, -OR 3 , -NO 2 , -NHz, -NR 3 R, -D-R 0 and optionally substituted C 4 alkyl;

R

7 ) is selected from -H, halogen, -OR 3 , -S(O)o.R 3 , -NO2, -- NH2, -NR 3

R

4 , and optionally substituted C 1 ,-alkyl; Q is selected from =N-, =C(H)-, and =C(CN)-; Z is selected from -S(O)o-2-, -0-, and -NR 5 -; Ar is either a five- or six-membered arylene or a five- or six-membered heteroarylene containing between one and three heteroatoms; G is either an optionally substituted cycloalkyl or an optionally substituted heteroalicyclic; each R 2 is independently selected from halogen, tribalomethyl, -CN, -NO 2 , -NH 2 , -OR 3 ,

-NR

3

R

4 , -S(O),.2R 3 , -sO 2

NR

3 , -CO2R3, -C(O)NR 3

R

3 , -N(R 3 )SO2R, -N(R 3

)C(O)R

3 ,

-N(R

3

)COR

3 , -C(O)R, and optionally substituted Clialkyl; each R 3 is independently -H or R ; each R 4 is independently selected from optionally substituted Cl-alkyl, optionally substituted aryl, optionally substituted aryl C 14 alkyl, optionally substituted heterocyclyl, and optionally substituted heterocyclyl Ci.6alkyl; or

R

3 and R, when taken together with a common nitrogen to which they are attached, fonn an optionally substituted five- to seven-membered heterocyclyl, said optionally substituted five- to seven-membered heterocyclyl optionally containing at least one additional annular heteroatom selected from N, 0, S, and P;

R

5 is -H or optionally substituted C 1

.

6 alkyl; each D is independently selected from -0-, -S(O)oo-2, and -NR'-; each R" is independently either R 3 , or according to formula XH; ~y (X) (W)n (XI)p XHf wherein X1, X2, and optionally X, represent the atoms of a saturated bridged ring system, said saturated bridged ring system comprising up to four annular heteroatoms represented by any of X1, X2, and X 3 ; wherein, 99 WO 2005/030140 PCT/US2004/031523 each X' is independently selected from -C(R)R 7-- -O-, -S(O)o.,. and -NR-; each X 2 is independently an optionally substituted bridgehead methine or a bridgehead nitrogen; each XO is independently selected from -C(R 6

)R

7 -, -0-, -S(O)o-r, and -NR-; Y is either: an optionally substituted lower alkylene linker, between D and either 1) any annular atom of the saturated bridged ring system, except X 2 when X 2 is a bridgehead nitrogen, or 2) any heteroatom, represented by any of R5 or R7; provided there are at least two carbon atoms between D and any annular heteroatom of the saturated bridged ring system or any heteroatom represented by any of R 6 or R7; or Y is absent, when Y is absent, said saturated bridged ring system, is directly attached to D via an annular carbon of said saturated bridged ring system, unless D is -SO-, in which case said saturated bridged ring system, is directly attached to D via an any annular atom of said saturated bridged ring system; m and p are each independently one to four; n is zero to two, when n equals zero, then there is a single bond between the two bridgehead X 2 ';

R

6 and R7 are each independently selected from -H, halogen, trihalomethyl, -CN, -NH2,

-NO

2 , -OR, -NR'R, -S(0)oR-2R4 -SO2NR 3

R

4 , -CO 2

R

3 , -C(O)NR 3 R4, -N(R)SO 2 R,

-N(R

3

)C(O)R

3 , -NCO 2

R

3 , -C(O)R, optionally substituted C.6allkyl, optionally substituted aryl, optionally substituted aryl C 1

.

6 alkyl, optionally substituted heterocyclyl, optionally substituted heterocyclyl C 1

.

6 alkyl, and a bond to either Y or D; or

R

6 and RY, when taken together are oxo; or R 6 and Ri, when taken together with a common carbon to which they are attached, form a optionally substituted three- to seven-membered spirocyclyl, said optionally substituted three- to seven-membered spirocyclyl optionally containing at least one additional annular heteroatorn selected from N, 0, S, and P;

R

8 is selected from -R3, Y, -SO 2

NR

3

R

4 , -CO 2

R

4 , -C(O)NRR 3 , -SO2R4, and -C(O)R; and 100 WO 2005/030140 PCT/US2004/031523 each R 30 is independently selected from halogen, trihalomethyl, -CN, -NO 2 , -NH 2 , -OR,

-NR

3

R

4 , -S(O)O.

2 W, -S02NRR, -CO2R 3 , -C(Q)NRR 3 , -N(R)SO 2

R

3 , -N(R 3 )C(O)R,

-N(R

3 )C0 2

R

3 , -C(O)R, and optionally substituted C 1

.

4 alkyl. (0087] In one example, the compound is according to paragraph [0086], wherein Z is either -0- or -NR 5 -. [0088] In another example, the compound is according to paragraph [0087], wherein at least one of R is -D-R 0 . (0089] In another example, the compound is according to paragraph [0088], wherein D is '-O- and at least one other R' is -OR. £0090] In another example, the compound is according to paragraph [0089], of formula XIla or XHIb: G Gs g gab H I 11 NR N , 0 0BD0 0 Z O NO R 3 O 2N NO XMa Xflb wherein Q 1 is either =N- or =C(H)-. [0091] In another example, the compound is according to paragraph [0090], wherein R0 is selected from CI5alkyl optionally substituted with at least one of optionally substituted amino, optionally substituted Cs 6 alkyl amino, optionally substituted C, 6 dialkyl amino, optionally substituted heteroalicylic, and a group of formula XI. [0092] In another example, the compound is according to paragraph [0091], wherein R3a is Cs.6alkyl. (0093] In another example, the compound is according to paragraph [0092], wherin Z is -0-. [0094] In another example, the compound is according to paragraph [0093], wherein G is selected from cyclopropyl, aziradine, cyclobutyl, and azetidine, each optionally substituted with between zero and four of R30. 101 WO 2005/030140 PCTIUS2004/0315 2 3 [0095] In another example, the compound is according to paragraph [0094], wherein Q is either =N- or=C(H-. [0096] In another example, the compound is according to paragraph [0095], wherein R2 is selected from -H, halogen, Ci-. alkyl and perfluoro C 1 - alkyl. [0097] In another example, the compound is according to paragraph [0096], wherein -N(Rsb)R 4 is selected from the following: HSb RSb (R 0-2-2 1. N rN

(R

6

))

4 (R(OR wherein J, is a five- to ten-mnembered ring, optionally substituted with between zero anid five of R120; each R(20 is independently selected from -H, halogen, trihalomethyl, -CN, -NO 2 , -NIH2z -O0, -NR -S(O)o- 2

R

3 , -SO2NR 3

R

3 , -C0 2

R

3 , -C(Q)NR 3

R

3 , -N(R3)SO2R 3 -N(R3)C(O)R 3 , -N(R 3 )CO2R, -C(O)R 3 , optionally substituted C 1 .alkyl, optionallY sdlbstituted aryl, optionally substituted aryl Cisalkyl, optionally substituted heterocyclyi and optionally substituted heterocyclyl C 1 -.alkyl; two of R', together with the atom or atoms to which they ate attached, combine to form an optionally substituted three- to seven-membered heteroalicyclic, said optionally substituted three- to seven-membered heteroalicyclic either spiro- to J or fused to J; E is selected from -0-, -N(R 5 )-, -CH-, and -S(O)o.Z-; each R60 is independently selected from halogen, tribalomethyl, -CN, -NO 2 , -NH 2 , -ORs,

-NR

3 R4, -S(O).2R 3 , -SO 2

NR

3

R

3 , -CO2R 3 , -C(Q)NR 3

R

3 , -N(R 3 )SOzR 3 , -N(R 3

)C(O)R

3 , -N(R3)CO 2 R, -C(O)R 3 , optionally substituted C1.alkyl, optionally substituted aryl, optionally substituted heteroaryl CI- 6 alkyl, and optionally substituted aryl C 1

.

6 alkyl; 102 WO 20051030140 PCT/US2004/031523 each methylene in any of the above formulae, other than those in a depicted ring, is independently optionally substituted with R5; and R" is selected from halogen, trihalomethyl, oxo, -CN, -NO,, -NH 2 , -OR 5 , -NRR 4 ,

-S(O)

0 -2R 3 , -SO 2

NR

3

R

3 , -CO2R 3 , -C(O)NRR 5 , -N(R)SOaR, -N(RY)C(O)R 3 ,

-N(R

3 )COzR 5 , -C(O)R 3 , optionally substituted aryl, optionally substituted aryl C.6alkyl, heteroaryl C 1

.

6 alkyl, and optionally substituted C 14 alkyl; or two of Rs, together with the carbon or carbons to which they are attached, can combine to form a three- to seven-membered alicyclic or heteroalicyclic; Rsbis equivalent to R3 as defined above; and

R

4 and R 5 are as defined above. [0098] In another example, the compound is according to paragraph [0097], of formula XIVa or XIVb: (R3064a (R3sao 0

(R

2 ) R2 R5 l Q Q j XIVa .X"~ [0099] In another example, the compound is according to paragraph [0098], wherein R 50 is C2.6alkyl optionally substituted with a group selected from optionally substituted amino, an optionally substituted alkylamino, optionally substituted dialkylamino, and optionally substituted heteroalicylic. (01001 In another example, the compound is according to paragraph [0099], wherein the heteroalicyclic portion of said optionally substituted heteroalicyclic of R 0 is selected from the group consisting of piperidine, piperazine, morpholine, thiomorpholine, thiomorpholine 1-oxide, thiomorpholine 1,1-dioxide, 2-oxo-morpholine, pyrrolidine, and azepine. (01011 In another example, the compound is according to paragraph [0099], wherein R 50 is according to formula XI. 103 WO 20051030140 PCT/US2004/031523 [0102] In another example, the compound is according to paragraph [0101], wherein the saturated bridged ring system according to formula XH has a geometry selected from the group consisting of [4.4.0], [4.3.0], [4.2.0], [4.1.0], [3.3.0], [3.20], [3.1.0], [3.3.3], [3.3.2], [3.3.1], [3.2.2), [3.2.1], [2.2.2], and [2.2.1]. 10103] In another example, the compound is according to paragraph 10102], wherein Y is selected from -CH 2 CH 2

CH

2 -, -CCH 2 CH2H-, -CH 2 CHr, -CH 2 -, and absent. [0104] In another example, the compound is according to paragraph [0103], wherein n is 0 and the saturated bridged ring system according to formula XII has a geometry selected from the group consisting of [4.4.0], [4.3.0], [4.2.0], [4.1.0], [3.3.0], [3.2.0], and [3.1.0]. [0105] In another example, the compound is according to paragraph [0104], wherein said saturated bridged ring system contains at least one annular nitrogen or at least one annular oxygen. [0106] In another example, the compound is according to paragraph [0105], wherein said saturated bridged ring system contains -NW-, wherein R8 is'selected from -H, optionally substituted C6alkyt -CO 2 R, -C(Q)NR 3

R

3 , -SO2R 3 , and -C(O)R. (0107) In another example, the compound is according to paragraph [0105], wherein said saturated bridged ring system is of formula XV, N Uq Xv wherein U' is selected from -0-, -S(O)o.-, -NR-, -CRR 7 -, and absent; and e is 0 or 1. [0108] In another example, the compound is according to paragraph [0107], wherein Y is -CH2-. [0109) In another example, the compound is according to paragraph [0108], wherein UI is -NR-, wherein R is selected from -H, optionally substituted lower alkyl, -COR 3 , -C(O)NReR 3 , -SO.R, and -C(O)R. [0110] In another example, the compound is according to paragraph [0108], wherein U. is -O-. 104 WO 2005/030140 PCTIUS2004/031523 [0111] In another example, the compound is according to paragraph [0108], wherein U1 is absent [0112] In another example, the compound is according to paragraph [0103], wherein Y is selected from -CH 2 CHr, -CH 2 -, and absent. [0113] In another example, the compound is according to paragraph [0112], wherein said saturated bridged ring system is of formula XVI, 0 0 RIO R 11 XVI wherein R 9 , R' 0 , and R" are each independently selected from -H, and -OR 1 2 ; or

R

9 is selected from -H, and -OR 1 2 , and R' 0 and R", when taken together, are either an optionally substituted alkylidene or an oxo; R a is selected from -H, -C(Q)R 3 , optionally substituted lower alkylidyne, optionally substituted lower arylalkylidyne, optionally substituted lower heterocyclylalkylidyne, optionally substituted lower alkylidene, optionally substituted lower alkylidenearyl, optionally substituted lower alkylideneheterocyclyl, optionally substituted lower alkyl, optionally substituted lower alkylaryl, optionally substituted aryl, optionally substituted lower heterocyclylalkyl, and optionally substituted heterocyclyl; or two R' 2 's, when taken together, form 1) a corresponding spirocyclic ketal when said two R 12 's stem from RW and R' 1 , or 2) a corresponding cyclic ketal when said two R2s stem from R 9 'nd one of R" andR. [0114] In another example, the compound is according to paragraph [0113], wherein one of R') and R" is -OR 1 2 , wherein R" is selected from -H, -C(Q)R, and optionally substituted lower alkyl; and R 9 and the other of R 10 and R" are both -H. [0115] In another example, the compound is according to paragraph [0114], wherein Y is either -CH 2 - or absent. [0116] In another example, the compound is according to paragraph [0113], wherein R 9 is an alkyl group containing at least one fluorine substitution thereon. 105 WO 20051030140 PCT/US20041031523 [0117] In another example, the compound is according to paragraph [0106], wherein said saturated bridged ring system is of formula XVIi. R x-Nf [0118] In another example, the compound is according to paragraph [0117], wherein Y is either -CH- or absent [0119] In another example, the compound is according to paragraph (0118], wherein R 8 is methyl or ethyl. [0120] In another example, the compound is according to paragraph [0119], wherein at least one of R is halogen. [0121] In another example, the compound is according to paragraph [0106], wherein said saturated bridged ring system is of formula XVHI. XVI [0122] In another example, the compound is according to paragraph [0121], wherein Y is [0123] In another example, the compound is according to paragraph [0122], wherein R' is methyl or ethyl. [0124) In another example, the compound is according to paragraph [0105], wherein said saturated bridged ring system is of formula XIX F1 3 N XIX wherein U is selected from -0-, -S(O)o-2, -NR-, -CR 6 Rt, and absent. (01251 In another example, the compound is according to paragraph [0124], wherein R 3 of formula XIX is selected from -H and optionally substituted alkyL. 106 WO 2005/030140 PCT/US20041031523 [0126] In another example, the compound is according to paragraph [0125], whemin U is either-CR 6

R

7 - or absent. [01271 In another example, the compound is according to paragraph [0126], wherein U is either -CH 2 - or absent. [0128] In another example, the compound is according to paragraph [0127], wherein Y is

-CH

2 -. [0129] In another example, the compound is according to paragraph [01061, wherein said saturated bridged ring system is according to formula XX. XX [0130] In another example, the compound is according to paragraph [0129], wherein R' is methyl or ethyl. [0131] In another example, the compound is according to any of paragraphs [0099] [0130], wherein R is selected from C_ alkyl, perfluoro C 1 4 alkyl, and halogen. [0132] In another example, the compound is according to paragraph [0131], wherein R 2 is selected from perfluoro C 1

.

3 alkyl and halogen. [0133] In another example, the compound is according t6 any of paragraphs (0099] [0130], wherein R is selected from halogen, -CN, -NO 2 , -NH 2 , -OR 3 , -NR3R,

-N(R

3

)SO

2

R

3 , -N(R 3

)C(O)R

3 , -N(R 3

)CO

2

R

3 , optionally substituted heterocyclyl, and optionally substituted heterocyclyl CI 6 alkyl, and (two of Re) together with the atom or atoms to which they are attached, an optionally substituted three- to six-membered heteroalicyclic, said optionally substituted three- to six-membered heteroalicyclic fused to the phenyl as in XWa or XMb. [0134] In another example, the compound is according to paragraph [0133], wherein R20 is selected from halogen, -NRR 4 , optionally substituted heterocyclyl, and optionally substituted heterocyclyl CI-alkyl, and (two of R 2 0) together with the atom or atoms to which they are attached, an optionally substituted five- to six-membered heteroalicyclic, said optionally substituted five- to six-membered heteroalicyclic fused to the phenyl as in XfVa or XWh. 107 WO 2005/030140 PCT/(JS2004/031523 [0135] In another example, the compound is according to paragraph [0134], wherein R selected from Ci..a alkyl, perfluoro CI-6 alkyl, and halogen. [0136] In another example, the compound is according to paragraph [0135], wherein R 2 is selected from perfluoro C1.3 alkyl and halogen. [0137] In another example, the compound is according to paragraph [0086], selected from Table 2. Table 2 Entry Name Structue N-(6-{[6,7- C N bis(methyloxy)quinolin-4 yl]oxy}-5-chloropyridin- 0 N 3-yl)-N'-(4- :c i fluorophenyl)yclopropan e-1,1-dicarboxamide N-(6-{ [6,7- H H bis(methyloxy)quinolin-4- N 2 y1]oxy}-5-chloropyridin- NF 3-yl)-N'-(4 fluorophenyl)cyclobutane -1,1-dicarboxamide N N-(6-{[6,7 bis(methyloxy)quinolin-4 3 yl]oxy}-5-chloropyridin- C N 0 3-yl)-N' (phenyhmethyl)cyclopropa ne-I,1-dicarboxamide N-(6-{[6,7- Ch bis(methyloxy)quinolin-4 4 yl]oxy)-5-chloropyridin- 0 N 3-yl)-N' phenylcyclopropane-1,1 dicarboxamide 108 WO 2005/030140 PCTIUS2004/031523 Table 2 Entry Name Structure N-[3-fluoro-4-({6 (methyloxy)-7-[(3 morpholin-4 5 ylpropyl)oxy]quinolin.-F yl}oxy)phenyl]-N'-(4-N fluorophenyl)cyclopropan OJ1 N e-1,1-dicarboxamide N-[3-fluoro-4-({6 (methyloxy)-7-[(3 piperidin-1 6 ylpropyl)oxy]quinolin-4- F yl}oxy)phenyl]-N'-(4.- N ftlorophenyl)cyclopropan e-1,1-dicarboxamide N-[3-fluoro-4-({6 (methyloxy)-7-[(3 piperidin-1 yl}oxy)phenyl]-N'-(4 fluorophenyl)cyclobutane -1,1-dicarboxamide ) N-(6-{[6,7- C N N bis(methyloxy)quinolin-4 8 ylloxy)-5-chloropyridin- , N N 3-yl)-N'-(2- 0 phenylethyl)cyclopropane K. -1,1-dicarboxamide N N-(6-{ [6,7 bis(methyloxy)quinolin-4 9 yl~oxy)-2-methylpyridin- AN 0 0 / F 3-yl)-N'-(4 fluorophenyl)cyclopropan e-1,1-dicarboxamide N-(4-((7-chloroquinolin- N % 4-yl)oxy-3- 0 0 10 fluorophenyl)-N'-(4- F fluorophenyl)cyclopropan e-1,1-dicarboxamide 109 WO 2005/030140 PCT/US2004/031523 Table 2 Entry Name Structure N-{4-[(7-chloroquinolin 4-yl)oxyjpheny1}-N'-(4- a 0 F fluorophenyl)oyclopropan e-1,1-dicarboxamide N-(4-{[6,7 bis(methyloxy)quinolin-4- 0 0 12 y1]oxy}phonyl)-N'-(4- F fluorophenyl)cyclopropan O e-1,1-dicarboxamide NN0 N-(4-{{6,7 bis(methyloxy)quinazolin 0 0 13 -4-yl]oxy}phenyl)-N'-(4- F fluorophonyl)cyclopropan

-

N e-1,1-dicarboxamide N N-(4-{ [6,7- F bis(methyloxy)quiazolin fluorophenyl)-N'-(4 fluorophenyl)cyclopropan / Z N e-1,1-dicarboxamide N-[3-fluoro-4-({6 (methyloxy)-7-[(3- N 1 morpholin-4- 0F ylpropyl)oxy]quinazolin- F 4-yl)oxy)phenyl]-N'-(4- - /0 fluorophenyl)cyclopropan e-1,1-dicarboxamide N-{5-chloro-6-[(6 (methyloxy)-7-{ [(1 methylpiperdin-4- 0 O 16 yl)methyl]oxyjquinolin- F 4-yl)oxy]pyridin-3-yI} N'-(4 fluorophenyl)cyclopropan e-i,1-dicarboxamide 110 WO 2005/030140 PCT/US2004/031523 Table 2 Entry Name Structure N-[5-chloro-6-({6- H (methyloxy)-7- CN [(piperidin-4- N o o 17 ylmethyl)oxy)quinolin-4- , yljoxy)pyridin-3-yl]M-0 (4 fluorophenyl)cyclopopan e-1,1-dicarboxamide N-[5-chloro-6-({6- N (methyloxy)-7 [(henylmethyI)oxy]quino N, F 18 lin-4-yl}oxy)pyridin-3 yl-N'--(4 fluorophenyl)cyclopropan e-1,1-dicarboxamide N-(4-{[7-{ [2-H (diethylamino)ethyl]oxy}- F N 6-(methyloxy)quinolin-4-00 19 yl]oxy}-3-fluorophenyl)-.O N'-(4 fluorophenyl)cyclopropan e-1,1-dicarboxamide N-(4-{[7-{[2 (diethylamino)ethyl]oxy } 6-(methyloxy)quinolin-4 20 ylloxy}-3-fluorophenyl)- o F fluoropheny])cyclobutane -1,1-dicarboxamide N-{3-fluoro4-[(6 (methyloxy)-7-{[(1 methylpiperidin-4- 0 0 21 yl)methyljoxyjquinazolin -4-yl)oxy]pheiiyl}-N'-(4 fluorophenyl)cyclopropan (>N e-1,1-dicarboxamide N N-(4-{[6,7- NHAH bis(methyloxy)quinolin-4 22 yl]oxyj-2-methyphenyl)- 0 , F N'-(4 fluorophenyl)cyclopropan / e-1,1-dicarboxamide N 111 WO 2005/030140 PCT/US2004/031523 Table 2 Entry Name Structure N-(4-fluorophenyl)-N'-(2 methyl-6-(6 (methyloxy)-7-[(3 23 morpholin-4- 0 23 ylpropyl)oxylquiniolin-4-. . yloxy)pyridin-3 yl]cyclopropane-1,1 dicarboxamide N-(4-{[6,7- N bis(methyloxy)quinolin-4 yl]oxy}-3-fluorophenyl)- 0 0F 24 N'-(4- a fluorophenyl)cyclopropan / .e-1,1-dicarboxamide I N-(6-{[6,7- H H bis(methyloxy)quinolin-4- ClNN yl]oxy}-5-chloro-2- 0 0 25 methylpyridin-3-yl)-N- 0 NF (4- o fluorophenyl)cyclopropan e-1,1-dicarboxamide N-[3-fluoro4-({7- H (methyloxy)-6-{(3- F morpholin-4- N 0 0 26 ylpropyl)oxy]quinazolin- F 4-yljoxy)phenyl]-N'-(4- c o N fluoropheny)cyclopropan e-1,1-dicarboxamideN N-(4-f[6,7- F N bis(me thyoxy)quinolin4- )a difluorophenyl)-N-(4- F fluorophenyl)cyclopropan / e-1,1-dicarboxamide : N-(4-{[6,7- FN bis(methyloxy)quinolin-4 28 difluorophenyl)-N'-(4 fluorophenyl)cyclopropan / e-1,1-dicarboxamide 112 WO 2005/030140 PCT/US2004/031523 Table 2 Entry Name Structure N-13-fluoro-4-({7- H H (methyloxy)-6-[(3- N N morpholin4- 0 0 29 ylpropyl)oxy]quinolin-4yljoxy)pheny]-N'-(4 fluorophenyl)cyclopropan e-1,1-dicarboxamide N-{3-fluoro-4-[(6 (methyloxy)-7-(2-methyl octahydrocyclo 30 pentaclpyrrol-5 ylmethoxy)quinazolin-4 yl)oxy]phenyl}-N'-(4 fluorophenyl)cyclopropan N e-1,1-dicurboxamide N-{3-fluoro-4-[(7- H (methyloxy)-6-[(1.- N mothylpiperidin-4- 0 31 yI)methyl]bxy}quinazolin N F -4-yl)oxy]phenyl}-N'-(4 fluorophenyl)cyclopropan e-1,1-dicarboxamide N-[5-fluoro-2-methyl-4- H H ({6-(methyIdxy)-7-[(3- N N morpholin-4- 0 0 a 32 ylpropyl)oxyjquinolin-4 yfloxy)phenyl]-N'-(4- 0 fluorophenyl)cyclopropan e-1,1-dicarboxamide N-(4-{[6,7- N bis(methyloxy)quinolin-4 33yl]oxy}-2,3,5~ F 0 O F10 trifluorophenyl)-N'-(4- F fluorophenyl)cyclopropan e-1,1-dicarboxamide N-(4-f [6,7- N bis(methyloxy)quinolin-4 34 yloxy}-5-fluoro-2- 0 0 F methylphenyl)-N'-(4 fluorophenyl)cyclopropan / e-1,1-dicarboxamide N 113 WO 2005/030140 PCT/US2004/031523 Table 2 Entry Name Structure N-(4-{[6,7- N bis(methyloxy)quinolin-4 35 yl~oxy}-2-chloro-5- O (C 0C 1 F me t hylphenyl)-N'-(4 fluorophenyl)cyclopropan/ e-1,1-dicarboxamide N-(3-fluoro-4-{[6- F N N hydroxy-7 36 (methyloxy)quinolin4 yI]oxyjphenyl)-N'-(4- HO fluorophenyl)cyclopropan e-1,1-dicarboxamide N-(4-fluorophenyl)-N'-[2- H H methyl-4-({6- N N (methyloxy)-7-[(3- o 37 morpholin-4- 0 a 0 0F ylpropyl)oxy]quinolin-4- N/ yl}oxy)phenyl]oyclopropa ne-1,1-dicarboxamide F N-[3-fluoro-4-({6 (methyloxy)-7-[(3- N piperazin-1- NH 38 ylpropyl)oxy]quinolin-4- NO yI}oxy)phenyl]-N'-(4- H fluorophenyl)cyclopropan NH e-1,1-dicarboxamide F 114 WO 20051030140 PCT/US2004/031523 Table 2 Entry Name Structure N-{3-fluoro-4-[(6- F N (mothyloxy)-7-{ [3-(4- O H methylpiperazin-1 39 yl)propyl]oxy}quinolin4 yl)oxylphenyl)-N'-(4- F fluorophenyl)cyclopropau e-1,-dicarboxamide HNN N-{3-fluoro-4-[(6-. (methyloxy)-7- {[(1- methylpiperidin-4- H 40 yl)methy]]oxy}quinolin 4-yl)oxy]phenyl}-N'-(4 fluorophenyl)cyclopropan 0 e-1,1-dicarboxamide IN NH N-(4-fluorophenyl)-N'-[4 ({6-(methyloxy)-7-[(3- O NH 41 morpholin-4 ylpropyl)oxy]quinolin-4- 0 yl}oxy)phenyl]cyclopropa 0 ne-I,-dicarboxamide .. N NH N-(4.--{[7-{[3 (diethylamino)propyl]oxy N }-6-(iethyloxy)quinolin- H 42 4-yl]oxy)-3 fluorophenyl)-N'-(4 fluorophenyl)cyclopropan F e-1,1-dicarboxamide0 11N 115 WO 2005/030140 PCT/US2004/031523 Table 2 Entry Name Structue N-(4-{[6,7 bis(nethyoxy)quinolin-4- F-O 43 ylloxy}-2-chloro-5- 4Q fluorphenyI)-N'-(4.- 0 fluorophenyl)cylopropan H N e-1,i-dicarboxamide H N-(4-{[6,7-O bis(methyloxy)-2- F F/ (methylthio)quinolin-4 44 yl]oxy}-3-fluorophenyl) fluorophonyl)cyclopropan H e-1,1-dicarboxamide N-(4-fluorophenyl)-N'-(4 { [2-methyl-6,7- F 45 bis(methyloxy)quinazolin 00o yl]oxylphenyl)cyclopropa Nb N N ne-i,1-dicarboxamide H N-(4-{{2-amino-6,7 bis(methyloxy)quinolin-4- F F 46 yl]oxy}-3-fluorophenyl) '-(4 fluorophenyl)cyclopropan N N e-i,l-dicarboxamide

NH

2 N-(3-fluoro4-{[2- F (methylamino)-6,7- F 47 bis(methyloxy)quinolin-4 yljoxylphenyl)-N'-(4 fluorophenyl)oyclopropan N e-1,1-dicarboxamide INH 116 WO 2005/030140 PCT/US2004/031523 Table 2 Entry Name Structure (1S,2R)-N-f3-fluoro-4- N1 ({6-(methyIoxy)-7-[(3 morpholin-4- F 48 ylpropyl)oxy]quinolin-4- 0 yljoxy)phenyl]-N'(4 fluorophonyl)-2- N 0HN methylcyclopropane-1,1- I dicarboxamide N FO (1R,2R)-N-[3-fluoro-4- N3 ({6-(methyloxy)-7-[(3 morpholin-4- F 49 ylpropyI)oxy]quinolin-4 yl)oxy)phenyl]-N-(4 fluorophenyl)-2- methylcyclopropano-1,1 dicarboxamide N O F (diethylino)propyl]oxy }-7-(methyloxy)quinolin- HN 50 4-yloxy}-3- F fluorophenyl)-N'-(4 fluorophenyl)cyclopropan HN e-1,1-dicarboxamide N N-(4-{ [6-{[2 (diethylamino)ethy1]oxy) 7-(methyloxy)quinolin-4- HN 0 0 51 ylloxy}-3-fluorophenyl)- 'o F N'-(4.- O fluoropheyl)cyclopropan HN e-1,1-dicarboxamide \ N 117 WO 2005/030140 PCT/US2004/031523 Table 2 Entry Name Structure 1,1-dimethylethyl 4-(3 [4-[(2-fluoro-4-{[Ik(1 . { [(4-O fluorophenyl)amino]carbo N 52 nyl }cyclopropyl)carbonyl F ]amino)phenyl)oxy]-6- H N (methyloxy)quinolin-7 ylloxy}propyl)piperazine- 0k0 1-carboxylate F 0 (1R,2R)-N-[3-fluoro-4 ({6-(methyloxy)-7-[(3 morpholin-4- F 53 ylpropyl)oxy]quinazoin 4-y1}oxy)phenylI-N'-(4 fluorophenyl)-2- 0 / HN methylcyclopropane-1,1- t dicarboxamide F N (1R,2R)-N-(4-{ [7-f [2 (diethylamino)cthyoxy}- I 6-(methyloxy)quinazoliu- 0 54 4-yI]oxyj-3- 0 fluorophenyl)-N'-(4 fluorophenyl)-2- N methylcyclopropane-1,1- N dicarboxamide F N N-(4-{[7-f[3- N (diethylamino)propyl]oxy 55 (methyoxy)quinazolU-4- F y3oxy}-3-fluorophenyl)-oF N'-(4- 0 n fluorophenyl)cyclopropan 0r I e-1,1-dicarboxamide NN*N. N 118 WO 2005/030140 PCT/US2004/031523 Table 2 Entry Namne Structure N-(4-{[7-{{[3-(4 acetylpiperazin-1-N y1)propyl]oxy)-6 56 (methyloxy)quinolin-4 yl]oxy)-3-fluoraphenyl)- F F0 N'-(4 fluorophenyl)cyclopropan e-1,1-dicarboxamide N H N ~ 1,1-dimethylethyl 4-(3- 1 {[4-[(2-fluoro-4- 0 {[((1R,2R)-1-{[(4-F fluorophenyl)aminolcarbo 0 57 Iyl}-2 methylcyclopropyl)carbon HN yl]aminojphenyl)oxy]-6.. N (methyloxy)quinolin-7- N O o F 1-carboxylate N-(4-{l[6,7 bis(methyloxy)quinolin4 NH 58 yl]oxylphenyl)-N'-(4 fluorophenyl)-1- 0 (phenylmethyl)azetidine- N O -- 3,3-dicarboxamide .. 119 WO 2005/030140 PCT/US2004/031523 Table 2 Entry Name Structure N-(4-{[6,7 bis(methyloxy)quinolin-4- 0 NH 59 yl]oxy}phenyl)-N'-(4 fluorophenyl)azetidine- 3,3-dicarboxanide N N (1R,2S)-N-{3-fluoro-4 [(6-(methyloxy)-7-{[3-(4 methylpiperazin-1- F 60 yl)propyl]oxy'quinolin-4 yl)oxy]phenyl)-N'-(4 fluorophenyl)-2- C 0 HN methylcyclcpropane-,- i N dicarboxamide a (1R,2R)-N-{3-fluoro-4 f(6-(methyloxy)-7-{[3-(4 methylpiperazin-l- F 61 yl)propyljoxy}quinolin-4 yl)oxy]phenyl}-N'-(4 fluorophenyl)-2- 0 HN mecthylcyclopropane-1,1-I dicarboxamide N F H NH (1R,2R)-N-[3-fluoro-4- N ({6-(methyloxy)-7-[(3 pipCrazin-1 62 ylpropyl)oxyquinolin-4 yl}oxy)pheny1]-N'-(4 fluorophenyl)-2" 0 OHN methylcyclopropane-1,1 dicarboxamide F N O H 120 WO 2005/030140 PCT/US2004/031523 Table 2 Entry Name Structure N-(3-fluoro-4- [7-({3.-4- F (1-methylethyl)piperazin- F 1-y1lpropylloxy)-6- NH 63 (methyloxy)quinolin-4- N yloxy}phenyl)-N'-(4- N fluorophenyl)cyclopropan H N e-1,1-dicarboxamide N-(4-{{7-{{3 (diethylamino)propyl]oxy F }-6- F 64 (methyloxy)quinazoin-4- 0 yl]oxy}-3-fluorophenyl)- NH N'-(4- 0 N"& N N N fluorophenyl)cyclopropan H e-1,1-dicarboxamide (lR,2R)-N-(4-{[7-{[3 (diethylamino)propylloxy }-6-(methyloxy)quinolin- 0 F 65 4-yl]oxy}-3 fluorophenyl)-N'-(4 fluorophenyl)-2- 0HNI methylcyclopropane-1,1 dicarboxamide F N O H (IR,2R)-N-(4-{[7-{[2- N (diethylamino)ethyl]oxy}-

N

0 F 6-(methyloxy)quinolin-4 66 yl]oxy)-3-fluorophenyl) N-(4-fluorophenyl)-2- 00H methylcyclopropane-1,1- N dicarboxamide N /!F 121 WO 2005/030140 PCT/US2004/031523 Table 2 Entry Name Structure (1R,2S)-N-(4-{ [7-{[3 (diethylamino)propylloxy }-6-(methyloxy)quinolin- N F 674-ylloxy)-3- 0 fluorophenyl)-N'-(4 fluorophenyl)-2- 0 HN methylcyclopropane-1,1- 'H dicarboxamide N F (IR,2S)-N-(4-{[7-{[2- N (diethylamino)ethyl]oxy}- K . F 6-(methyloay)quinolin-4 68 yl]oxy}-3-fluorophenyl) N'-(4-fluorophenyl)-2 methylcyclopropane-1,1- N 0 H dicarboxamideN F N-(4-{ [7-{[2 (diethylamino)ethyl]oxy}- N 6-(methyloxy)quinazolin 69 4-ylloxy}-3- N fluorophenyl)-N'-(4- 0 -NH fluorophenyl)cyclobutane -1,1-dicarboxamide ~ F rNH (IR,2S)-N-[3-fluoro-4- N, ({6-(methyloxy)-7-[(3- r piperazin-1- F 70 ylpropyl)oxylquinolin-4 y1)oxy)phenyl]-N-(4 fluorophenyl)-2- 0 tH metbylcyclopropane-1,1 dicarboxamide N ./ F N 122 WO 2005/030140 PCT/US2004/031523 Table 2 Entry Name Structure (1R,2R,3S)-N-[3-fluoro- N 4-({6-(methyloxy)-7-[(3 morpholin.-4-F 71 ylpropyl)oxy]quinoin-4-\ y1}oxy)phenylj-N'-(4- fluorophenyl)-2,3- O HN dimethylcyclopropane- I 1,1-dicarboxamide F oN (LR,2R,3S)-N-{3-fluoro- N 4-[(6-(mothyloxy)-7-{[3- K (4-methylpiperazin-1 72 yl)propyljoxy)quinolin-4 yl)oxy]phenyl}-N'-(4 fluorophenyl)-2,3- 0 HN dimethylcyclopropane- C ii 1,1-dicarboxamide FN ' (1R,2R,3S)-N-[3-fluoro 4-({6-(methyloxy)-7-[(3 morpholin-4- $ F 73 ylpropyl)oxy]quinazolin 4-y1}oxy)phenyl]-N'-(4- 0 fluorophenyl)-2,3- 0H dimethylcyclopropane- N ))1k. 1,1-dicarboxamide F N (IR2R,3S)-N-{3-fluoro- N 4-[(6-(methyloxy)-7-{[3 (4-methylpiperazin-1- o F 74 yl)propylloxylquinazolin 4-yl)oxy]phenyl)-N'-(4 fluorophenyl)-2,3- N H dimethylcyclopropane- NCN X O 1,1-dicarboxamide F N 123 WO 2005/030140 PCT/US2004/031523 Table 2 Entry Name Structure N-[3-fluoro4-({6- CD3 (methyloxy)-7-[(3- N morpholin-4 75 ylpropyl)oxy]quinazoin 4-yI1}oxy)phenyl]-JN(4- N NH fluorophenyl)cyclobutane NH -1,1-dicarboxamide F (2R,3R)-N-[3-fIuoro-4- N ({6-(methyloxy)-7-[(3- r morpholin-4- F 76 ylpropyl)oxy]quinolin-4- o yl}oxy)phenyl]-N'-(4 fluorophenyl)-2,3- No H dimethylcyclopropane- A 1,1-dicarboxamide F N (2R,3R)-N-(4- [7- [3 (diethylamino)propylloxy C, F }-6-(mnethyloxy)quinolin.-. 4-yl]oxy}-3- o fluorophenyl)-N'-(4 fluorphenyl)-2,3 dimethylcyclopropane- N 1,1-dicarboxamide F N N-(4-{7-{[3- oF (diethylamino)propyl]oxy }-6-(methyloxy)quinolin 4-yljoxy}-3- N H fluorophenyl)-N'-(4 fluorophenyl)-2,2- rN N FN dimethylcyclopropane- H 1,1-dicarboxamide 124 WO 2005/030140 PCT/US2004/031523 Table 2 Entry Name Structure N-[3-fluoro-4-({6- F (methyloxy)-7-[(3 morpholin-4 79 'ylprpyl)oxyjquiazolin- Ha 4-yljoxy)phenyl]-N.(4 fluorophenyl)-2,2- N N N F N dimethylcyclopropane 1,1-dicarboxamide (LR,2R,3S)-N-(4-{[7-f 3- F (diethylamino)propyl]oxy }-6-(methyloxy)quinolin fluorophenyl)-N'-(4- I1HN fluorophenyI)-2,3- N FN dimethylcyclopropane- H 1,1-dicarboxamide N-(4-{[7-([2- N) (diethylamino)ethyIjoxy} 6-(methyloxy)quinolin4 81 yl]oxy}-3-fluorophenyl) N'-(4-fluorophenyl)-2,2- H dimethylcyclopropane 1,1-dicaboxamide F aN HI (1R,2R,3S)-N-(4-{[7-{[2- N (diethylamino)ethyl]oxy}- F 6-(methyloxy)quinolin-4- O 82 yl]oxy}-3-fluorophenyl) N'-(4-fluorophenyl)-2,3- HN dimethylcyclopropane 1,1-dicarboxamide F N N-[3-fluoro-4-((6- F (methyloxy)-7-[(3- 0 morpholin-4 83 ylpropyl)oxyjquinolin-4- H yl}oxy)phenyl]-N'-(4- 1 fluorophenyl)-2,2- N N F dimethykcyclopropane 1,1-dicarboxamide O 125 WO 2005/030140 PCT/US2004/031523 Table 2 Entry Name Structure N-(4-{ [7-{[2- F (diethylamino)ethyl]oxy}- 0 6-(methyloxy)quinazolin 4-yfloxy) -3- f 84 fluorophenyl)-N'-(4- N C O fluoophenyl)-2,2- NW F N O dimethylcyclopropanoe 1,1-dicarboxamide N-(4-f [7-f [3 (diethylamino)propyl-6xy 85 (methyloxy)quinazolin-4 yl]oxy}-3-fluorophenyl) N'-(4-fluorophenyl)-2,2 N r N,,,,N F N0 dimethylcyclopropane- H 1,1-dicarboxamide N-(4-{{7- {[3- F (diethylamino)propyl]oxy N }-6 86 (methyloxy)quinazolin-4- N ylloxy}-3-fluorophenyl)- N N'-(4- O NH fluorophenyl)cyclobutane -H -1,1-dicarboxamide /F N-{3-fluoro-4-[(6- C-N (methyloxy)-7-{ [3-(4- N methylpiperazin-1 87 yI)propyl]oxyjquinazolin-

N

4-yl)oxyjphenyl}-N'-(4 fluorophenyl)cyclobutane . N;H NH -1,1-dicarboxamide NHY F NH N-[3-fluoro-4-({6- F (nethyloxy)-7-[(3 piperazin-1 88 ylpropyl)oxy]quinazolin- "'N 4-yl~oxy)phenyl]-N'-(4 88N HN fluorophenyl)cyclobutane - 0 \ NH\O4 NH -1,1-dicarboxamide -0 126 WO 2005/030140 PCT/US2004/031523 Table 2 Entry Name Structure (2R,3R)-N-[3-fluor-4 ({6-(methyloxy)-7-[(3 morpholin-4- O 0 89 ylpropyl)oxy]quinazolin- o 4-yl oxy)phenyl]-N-(4 fluorophenyl)-2,3- NH dimethylcyclopropane- NF 1,1-dicarboxamide N NFa N-(4-[7-{[3 (diethylamino)propyl]oxy N }-6-(methyloxy)quinoliu- N 90 4-yl]oxy}:-3 fluorophenyl)-N'-(4 fluorophenyl)cyclobutane NHO N -1,1-dicarboxamide N N-{3-fluoro4-{(6- 0 F (methyloxy)-7-{[3-(4- N methylpiperazin-1 91 yl)propyl]oxy}quinolin-4- N yl)oxy]phenyl)-N-(4 fluorophenyl)cyclobutane NH -1,1-dicarboxamide N (1R,2R)-N-(4-f [7-{[3- No F (diethylamino)propyl]oxy }-6 92 (methyloxy)quinazolin-4 ylloxy}-3-fluorophenyl)- N MN'-(4-fluorophenyl)-2- N FN methylcyclopropane-1,1- H , dicarboxamide4 127 WO 2005/030140 PCT/US2004/031523 Table 2 Entry Name Structure (IR,2R)-N-{3-fluoro-4- 0 [(6-(nethyloxy)-7-{[3-(4 methylpiperazin-1 yl)propyljoxyjquinazoln- 0HNI 9 4-y)oxy]phenyi}-N'-(4- FN 20-O fluorophenyl)-2 methyloyclopropane-1,1 dicarboxamide (2R,3R)-N-(4-{ [7-{[2- F (diethylamino)ethyloxy} 6-(methyloxy)quinazolin 94 4-yljoxy}- 3 - N j oH fluorophenyl)-N'-( 4 - N N I fluorophenyl)- 2

,

3

-

F-N dimethylcyclopropane 1,1-dicaboxamide-- (2R,3R)-N-(4-{ [7-{[3- 0 F (diethylamino)propYlOxy 0/ }-6- 1 0OW (methyloxy)quinazoliKn-4 95 y]oxy}-3-finorophenYl) N'-(4-fluorophenyl)-2,3- (N N F A N dimethycyclopropane- H 1,1-dicarboxamide (1R,2R)-N-[3-fluoro-4- I0 F ({6-(methyloxy)-7-[(3-0N(o piperazin-1 ylpropyl)oxy]quinazolin- /HN .6 4-ylloxy)phenyl]-NN(4 N Fa ' fluorophenyl)-2 - methylcyclopropane-1- N dicarboxamide H (2R,3R)-N-(4-{[7-{[2- F (diethylaino)ethylloxy}- 0 k 6-(methyloxy)quinolin-4- HNW '97 yl]oxy}-3-fluorophenyl)- N 1 N!-(4-fluorophenyl)-2,3- N F1 O* dimthylcyclopropane-F 1,1-dicarboxamnide S128 WO 2005/030140 PCTUSZO04/031523 Table 2 Entry Name taur bis(methyloxy)quinolin-4 98 mIoy~hnI)-d(4 opropane-1,1-NN dicarboxamideH N-(4-{ (6,7 bis(metbyloxy)quinolin4- O 99 yI]oxyjphenyl)-N'-(2-00 morpholi-4 ylethyl)cyclopropane- 1,1-NN dicarboxamideH N-(4-1 [6,7-0 10 bis(mthyloxy)quinolin-4- N (piperidin-1- - N 1 ylmethyl)phenyljcyclopro N pane-1,1-dicarboxanike NNC N-(4-{[(6,7- ND011 bis(mothyloxy)quinolin-4-\N 1% 101 yI~oxyjpheny)-NL[2, yhmethyl)pbrnyl~cYclopro N pane-1,1-dicarboxamide % KN

C

0 N-(4-[[6,7- N bis(methyloxy)quinolin-4 102 y1~oxyjphe-ny1)-NP-[3- 0 (morpholin-4- N ylmethyl)pheuyl~cyelopro N pane-i, -dicaboxamide N 129 WO 2005/030140 PCTIUS2004/031523 Table 2 Entry Name Structure N-(4-{[6,7- 0 bis(methyloxy)quinolin4- N 103 yljoxy}phenyl)-N'-[2- - 0,. (morpholin-4- N 0 ylmethyl)pheny1]cyclopro NH I pane-1,1-dicarboxamide O NN N-(4-{[6,7 bis(mothyloxy)quinolin-4 104 ylloxy}phenyl)-N'- NH 0 0 phenylcyclopropane-1,1 dicarboxamide A N -N-[3-. ~ (aminomethyl)phenyl]-N' 105 (4-{[6,7-0 bis(methyloxy)quinolin-4- NH 0 O ylloxy}phenyl)cyclopropa N ne-1,1-dicarboxamide N'C N-(4-{ [6,7- N bis(methyloxy)quinolin-4 106 yl]oxy}phenyl)-N'-[3- 0 (piperidin- 1 ylmethyl)phenyl)cyclopro NH O pane-1,1-dicarboxamide O N N-(4-f (6,7- N$3 bis(mothyloxy)quinolin-4- 0 107 yl]oxy)phenyl)-N'-[3 (pyrrolidin-1-NH0' ylmethyl)phenyllcyclopro NH pane-1,1-dicarboxamide N 130 WO 2005/030140 PCT/JS2004/031523 [0176] Another aspect of the invention is a pharmaceutical composition comprising a compound according to any one of paragraphs [0033]-[0120] and a pharmaceutically acceptable carrier. [0177] Another aspect of the invention is a metabolite of the compound or the pharmaceutical composition according to any one of paragraphs [00221-10122]. [0178] Another aspect of the invention is a method of modulating the in vivo activity of a kinase, the method comprising administering to a subject an effective amount of the compound or the pharmaceutical composition according to any of paragraphs [0033] [0121]. [0179] Another aspect of the invention is the method according to paragraph [0123], wherein modulating the in vivo activity of the kinase comprises inhibition of said kinase. (0180] Another aspect of the invention is the method according to paragraph [0124], wherein the kinase is at least one of c-Met, KDR, c-Kit, fit-3, and fIt-4. [0181] Another aspect of the invention is the method according to paragraph [0125], wherein the kinase is c-Met. [0182] Another aspect of the invention is a method of treating diseases or disorders associated with uncontrolled, abnormal, and/or unwanted cellular activities, the method comprising administering, to a mammal in need thereof, a therapeutically effective amount of the compound or the pharmaceutical composition as described in any one of paragraphs [00331-[0121]. [0183] Another aspect of the invention is a method of screening for a modulator of a kinase, said kinase selected from c-Met, KDR, c-Kit, fit-3, and fIt-4, the method comprising combining a compound according to any one of paragraphs [0033]-[01201, and at least one candidate agent and determining the effect of the candidate agent on the activity of said idnase. [0184] Another aspect of the invention is a method of inhibiting proliferative activity in a cell, the method comprising administering an effective amount of a composition comprising a compound according any one of paragraphs [0033]-[0120] to a cell or a plurality of cells. [0185] As mentioned, although improved quinolines and quinazolines of the invention can be made via conventional serial methods, due to their complex structure, more efficient 131 WO 2005/030140 PCT/US2004/031523 routes are desirable, particularly convergent syntheses. Thus, the present invention also comprises a process for preparing a compound of Formula XXI, z Ar-B%i..,T Z ) L (R20 (R I)0 4 . XXI comprising reaction of a compound of Formula XXH, with a compound of Fomula XXII

P

1 (R1) rK 'tj Ar A-B, V-T N R 70 p22) s wherein, each R 1 is independently selected from halogen, -OR, -NOz, -NH 2 , -NR 3

R

3 , -D-R 0 and optionally substituted C1.6alkyl;

R

70 is selected from -H, halogen, -OR 3 , -S(O)ozR 3 , -NO 2 , -NH 2 , -NR 3

R

3 , and optionally substituted C 14 alkyl; J is selected from =N-, =C(H)-, =C(halogen)-, and =C(CN)-; Z is selected from -S(0)o-2-, -0-, and -NRW-; each R 5 is independently selected from -H, optionally substituted C 1

.

6 alkyl, optionally substituted aryl, and optionally substituted aryl C 1 .alkyl; Ar is either a five- to ten-membered arylene or a five- to ten-membered heteroarylene containing between one and three heteroatoms;

R

2 is selected from -H, halogen, trihalomethyl, -CN, -NO 2 , -NHz,, -OR 3 , -NR3R', -S(0) 0

.

2 R, -S0 2 NRR, -CO2R 3 , -C(O)NR3Ra, -N(R 3

)SO

2

R

3 , -N(R 3

)C(O)R

3 ,

-N(R

3

)CO

2

R

3 , -C(O)R 3 , and optionally substituted C 1

.

4 alkyl; each R' is independently selected from -H, -Si(R 5 )(R)R, optionally substituted lower alcyl, optionally substituted aryl, optionally substituted arylalkyl, and optionally substituted heteroarylalkyl; 132 WO 2005/030140 PCT/US2004/031523 two R3, together with the nitrogen to which they arm attached, form a four- to seven membered heteroalicyclic, said four- to seven-membered hetermalicyclic optionally containing one additional heteroatom; when one said additional heteroatom is a nitrogen, then said nitrogen is optionally substituted with a group selected from -H, trihalomethyl,

-SO

2

R

5 , -SO 2

NR

5 R, 'CO 2

R

5 , -C(O)NR 5

R

5 , -C(O)R 5 , and optionally substituted lower alkyl; B is selected from absent, -N(R")-, -N(SOzR')-, -O-, -S(0)o-2-, and -C(=0)-; L is selected from absent, -C(=S)N(R' 3 )-, -C(=NR')N(R 3 )-, -S0 2 N(R')-, -SO-, -C(=0)N(R"')-, -N(R')-, -C(=0)C1-2alkyN(R'3)-, -N(R"')Cj-2alkylC(=0)-, -C(=0)Co.,alkylC(=O)N(R'")-, -C(=0)-, -CO 4 alkylene-, -C(=O)Co.1alkylC(=0)OR'-, -C(=NRt)Co.1alkylC(=O)-, -C(=0)COalkyC(=O)-, and an optionally substituted four- to six-membered heterocyclyl containing between one and three annular heteroatoms and comprising at least one nitrogen; T is selected from --LH -R", -Coalkyl, -Co4alkylQ, -OCoalkylQ, -Cg.alkylOQ,

-N(R'

3 )CoalkylQ, -SO2CoalkylQ, -C(=0)C 4 alkylQ, -CoalkyN(R)Q, and

-C(=O)N(R

3 )CoaalkylQ, wherein each of the aforementioned Co 4 alkyl is optionally substituted; Q is a five- to ten-membered ring system, optionally substituted with between zero and four of R20; each R 20 is independently selected from -H, halogen, trihalomethyl, -CN, -NOz, -Nflz, -OR, -NR 3 R, -S(O).

2

R

3 , -SOzNR'R', -CO2R 3 , -C(O)NR 3 R, -N(R')SO 2

R

3 , -N(R3)C(O)R, -N(R 3

)CO

2 R', -C(O)R, optionally substituted CI-6alkyl, optionally substituted aryl, optionally substituted aryl C 1 4alkyl, optionally substituted heterocyclyl, and optionally substituted heterocyclyl CI-alkyL two of 0, together with the atom or atoms to which they are attached, combine to form an optionally substituted three- to seven-membered heteroalicyclic, said optionally substituted three- to seven-membered heteroalicyclic either spiro- to Q or fused to Q; D is selected from -0-, -S(O)oa.-, and -NR' 5 -;

R

50 is either R?, or according to formula XXXV; 133 WO 2005/030140 PCT/US2004/031523 X2I wherein X', X2, and optionally X0, represent the atoms of a saturated bridged ring system, said saturated bridged ring system comprising up to four annular heteroatoms represented by any of X 1 , XK, and X0; wherein, each X' is independently selected from -C(R)R 7 -, -0-, -S(O)o-2-, and -NR-; each X2 is independently an optionally substituted bridgehead methine or a bridgehead nitrogen; each X3 is independently selected from -C(R)R-, -0-, -S(O)o-2-, and -NR-; Y is either: an optionally substituted C 5 alkylene linker, between D and either 1) any annular atom of the saturated bridged ring system, except X 2 when )2 is a bridgehead nitrogen, or 2) any heteroatom, represented by any of R! or R 7 ; provided there are at least two carbon atoms between D and any annular hetezuatom of the saturated bridged ring system or any heteroatom represented by any of R or t; or Y is absent, when Y is absent, said saturated bridged ring system, is directly attached to D via an annular carbon of said saturated bridged ring system, unless D is -SO2-, in which case said saturated bridged ring system, is directly attached to D via an any annular atom of said saturated bridged ring system; m and p are each independently one to four; n is zero to two, when n is zero, then there is a single bond between the two bridgehead X2s; R6 and R7 are each independently selected from -H, halogen, trihalornethyl, -CN, -NH 2 ,

-NO

2 , -OR 3 , -NRR 3 , 'S(0) 0 -2R 3 , -SO 2

NR

3

R

3 , -CO2R3, -C(O)NR 3

R

3 , -N(R)SO 2 Rs,

-N(R

3

)C(O)R

3 , -NCO 2

R

3 , -C(0)R, optionally substituted Cisalkyl, optionally substituted aryl, optionally substituted aryl Ci.

6 alkyl, optionally substituted heterocyclyl, optionally substituted heterocyclyl a Cisl1kyl; and a bond to either Y or D; or 134 WO 2005/030140 PCT/US2004/031523

R

6 and i, when taken together are oxo; or

R

6 and R7, when taken together with a common carbon to which they are attached, fori a optionally substituted three- to seven-membered spirocyclyl, said optionally substituted three- to seven-membered spirocyclyl optionally containing at least one additional annular heteroatom selected from N, 0, S, and P; R is selected from -R, Y, -SO 2

NR

3

R

3 , -CO2R 3 , -C(O)NRR 3 , -SO 2

R

3 , and -C(O)R;

R

1 - is selected from -H, -C(=O)R 3 , -C(=O)OR 3 , -C(=O)SR 3 , -80R 3 , -C(=O)N), and optionally substituted C1-galkyl; two R', together with the atom or atoms to which they are attached, can combine to form a heteroalicyclic optionally substituted with between one and four of R 6 1, said heteroalicyclic comprising up to four annular heteroatoms, and said heteroalicyclic optionally comprising an aryl or heteroaryl fused thereto, in which case said aryl or heteroaryl is optionally substituted with an additional one to four of R0; R14 is selected from -H, -NO 2 , -NH 2 , -N(R 3

)R

3 , -CN, -OR 3 , optionally substituted Ci-salkyl, optionally substituted heteroalicyclyl C 1 .aalkyl, optionally substituted aryl, optionally substituted aryl C 1 .6alkyl and optionally substituted heteroalicyclic; R15 is a group -M-M 2 , wherein M' is selected from absent, -C(=S)N(R' 3 )-, -C=Na)(R)- _SO2N(R13)-, -SOz-, -C(=0)N(Rll)-, -C(=0)C(=0)N(R) -C04alkylene-, -C(=O)-, and an optionally substituted four to six-membered heterocyclyl containing between one and three heteroatoms but comprising at least one nitrogen; and

M

2 is selected from -H, -Co.aalkyl, alkoxy, -C(=O)Co4alkylQ, -Co 4 alkylQ, -OCoWalkylQ-, -N(R')Co 4 alkylQ-, and -C(=O)N(R)Co4alky1Q; R60 is selected from -H, halogen, tribalomethyl, -CN, -NO 2 , -NH 2 , -OW, -NR 3

R

3 , -S()o..2R 3 , -SO2NR'R 3 , -CO2R', -C(O)NR 3 R', -N(R3)SO 2

R

3 , -N(R 3

)C(O)R

3 ,

-N(R

3

)CO

2

R

3 , -C(O)R 3 , optionally substituted C1.6alkyl, optionally substituted aryl, optionally substituted heteroaryl C..alkyl, and optionally substituted aryl CI-alkyl; two of R 60 , when attached to a non-aromatic carbon, can be oxo; P' is a suitable leaving group; and

P

2 is selected from -H, a metal, and a group removed in-situ when combining XXU and XXHI to make XXI. 135 WO 20051030140 PCT/US2004/031523 [0131] In one example, the process is according to paragraph [0130], wherein Ar is para phenylene as defined by the substitution pattern of .- Z- and -B-L-T about said phenylene. [0132] In another example, the process is according to paragraph [0131], wherein Z is either -0- or -NR'-. [0133] In another example, the process is according to paragraph [0132], wherein -B-UrT is selected from the following:

R

18 RIB RI RI1 I N Q 0-3 1..4 - N N Q ~ yN tyrk% ~Nl.. Q NR14 R1 . q1-2 f0-2 N0N N E 0 NyNyS RN R 0 N /2 0-2 0 Y01 vNy >y5<

R

13

R

1 3 RR1 I 1 1 04 1 01 0-3 N N Q N RN R\ R o 0 0 Oi O 12 0 0 N N R0 N N N'f 0 0 0 0I 136 WO 2005/030140 PCT/US2004/031523 H1 3 R R 3 Ri )1-2 N x N a NyNyRO N N Q S 0 s 12 -3 NQ N R N N RS S 0S S 1 I 13 2 0 N~XERQ N O R N 0 0 0 o O 1-3 0- 3\/ 1 R13Ft 1 N E NN 1e R1 1IB Rer O 1 EH OHN o .0 0 O0 0 oR Ky? ,kQ 0v 00N 3 E C1.-4ky 1 37 RH 13 R's

R

13 0-1 0-3 N A' {j &e ) % 0x 0 0 'OR 5 RIB F 13 Rt 13 F11 3 N- 1 02 1 N 6 ~NR1B - NY E%,.8ly 0 N OR 0 0 wherein Q, 1e, and R(13 are as defined above; each E is selected from -0-, -NQ')-, -CR 2 , and -S(O)o.z-; M is selected from -0-, -N(R' 3 )-, -CR 2 -, and -C(=Q)N(R' 3 )-; each V is independently either =N- or =C(W-; each methylene. in any of the above formulae is 137 WO 2005/030140 PCT/US2004/031523 independently optionally substituted with R 2; and R2 is selected from halogen, trihalomethyl, -CN, -NO 2 , -NH 2 , -OR, -NR3RI, -S(0)oR', -SO2NRR3, -COzR 3 , -C(O)NRR, N(RY)S0 2 Ra, N(R 3

)C(O)R

3 , -N(R')CO2R3, -C(O)RW, optionally substituted aryl, optionally substituted aryl Ci-6alkyl, heteroaryl C 4 alkyl, and optionally substituted Cialkyl; two of R2, together with the carbon or carbons to which they are attached, can combine to form an optionally substituted three- to seven-membered alicyclic or heteroalicyclic; two of R 25 on a single carbon can be oxo. [0134] In another example, the process is according to paragraph [01331, wherein there is one of R1 that is -D-Re and another of R' that is -OR"'. [0135] In another example, the process is according to paragraph [0134], wherein D is [0136] In another example, the process is according to paragraph [01351, wherein -O-R 50 and -OR" are interchangeably located at the 6-position and 7-position of the quinazoline or quinoline according to Formula XXI. [01371 In another example, the process is according to paragraph [0136], wherein -OR 3 ' is selected from -OH, -OSi(R 5

)(R')R

5 , and optionally substituted -OCI 6 alkyl. [0138] In another example, the process is according to paragraph [0137], wherein J is =N or =C(H)-. [0139] In another example, the process is according to paragraph [0138], wherein -B-L-T is selected from:

R

13 0 R 1 s RIs ls R13 R13 - 0 R13 0 R0 s 1 3 R e R's R~138R3i WO 2005/030140 PCT/US2004/031523 U00-3

Y

13 R3 E 090 (RGo O O( rA 8

),.

4 o 0 (V). wherein Q, R20, R13, E, and R4 are as defined above; each methylene in any of the above formulae, other than those in a depicted ring, is independently optionally substituted with R25; and R is selected from halogen, trihalomethyl, oxo, -CN, -NO 2 , -NH 2 , -OR 3 , -NPR, -S(O)4.2R 3 , -SO2NR 3

R

3 , -CO 2

R

3 , -C(O)NR 3

R

3 , -N(R 3 )SO2R 3 , -N(R)C(O)R,

-N(R

3 )CO2R 3 , -C(O)R, optionally substituted aryl, optionally substituted aryl C 1 -alkyl, heteroaryl C 1

.

6 alkyl, and optionally substituted C 1 .alkyl; two of RS, together with the carbon or carbons to which they are attached, can combine to form a three- to seven membered optionally substituted alicyclic or heteroalicyclic. [0140] In another example, the process is according to paragraph [0139], wherein Q is selected from the following three formula: (R~20---(R2o.=

(R

2 0 )o.3 wherein R 20 is defined as above, and P is a five- to seven-membered ring, including the two shared carbons of the aromatic ring to which P is fused, P optionally containing between one and three heteroatoms. [0141] In another example, the process is according to paragraph [0140), wherein -B-L-T is either of formula XXV or formula XXVI, (RaG)o.4

R

1 3a 0 O A' 0-3 ;rj~l: -0

R

1 ' (R 20 )0..4 XXV XXVI wherein R20 is defined as above; G is either an optionally substituted cycloalkyl or an optionally substituted heteroalicyclic; each R" is independently selected from halogen, trihalomethyl, -CN, -NO 2 , -NH 2 , -OR', -NR 3 R, -S(O)0-zR', -SO 2

NR

3

R

3 , -CO 2 R', -C(O)NRRW, -N()SO2R, -N(R)C(0)R, -N(R3)CO2R 3 , -C(O)R3, and optionally 139 WO 20051030140 PCT/US20041031523 substituted C 14 alkyl; and Ra and R 3 b are each independently selected from -H and optionally substituted C-alkyl. [0142] In another example, the process is according to paragraph [0141], wherein a compound of formula XXIIa is combined with a compound of formula XXIJa to make a compound of formula XX~a, 0 1 C.akkyy-- (R2 0 kb 1(20 R.%RN.O NNR7O XXaXXaa wherein -B-L-T, Z, J, Roh and R 2 are as defined above; R 70 is selected from -H, -N02,

-NH

2 , and -NR 3

R

3 ; provided when Z is -N4(R 5 )- that R 5 is selected from -H, Ci-salkyl, and aryl C1-3alkyl; P 3 is selected from halogen, optionally substituted alkyl-S(O)ao-, optionally substituted arylsulfonate, optionally substituted alkylsulfonate, a group containing boron, an azide, a group containing phosphorus, and a metal; and P 2 is selected from -H and a metal. [0143] In another example, the process is according to paragraph [0142], wherein P 2 i selected from -H, lithium, sodium, potassium, cesium, copper, palladium, and titanium. [0144] In another example, the process is according to paragraph [0143], wherein Z is -0-. [0145] In another example, the process is according to paragraph [0144], wherein P 1 is selected from chlorine 1 bromine, a toluene sulfonate, and trifluoromethansulfonate. [0146] In another example, the process is according to paragraph [0145], wherein R 70 is -H. [0147] In another example, the process is according to paragraph [0146], wherein J is =C(H)-. [0148] In another example, the process s according to paragraph [0147], wherein R 2 is selected from Che alkyl, perfluoro Cs t e alkyl, and halogen. 140 WO 2005/030140 PCT/US2004/031523 [0149] In another example, the process is according to paragraph [0148], wherein XX~a and XXIa are heated together, optionally with a base, optionally with microwave radiation, to fann XXla. [0150] In another example, the process is according to paragraph [0149, wherein the base is selected from an organic base, an inorganic base, and a combination of an organic base and an inorganic base. [01511 In another example, the process is according to paragraph [0150], wherein the base is selected from 2,6-lutidine, 4-NN-dimethylaminopFyridine, and a metal carbonate. [01521 In another example, the process is according to paragraph [0151], wherein XXIla and XXma are heated together in a solvent with said base, at between about 40"C and 200"C for between about one hour and twerty-four hours to form XXIa. [0153) In another example, the process is according to paragraph [0152), wherein the solvent is an organic solvent. [0154] In another example, the process is according to paragraph [0153), wherein one molar equivalent of XXa is combined with between about one quarter and four.molar equivalents of XXTIIa. [0155] In another example, the process is according to paragraph [0154), wherein one molar equivalent of XXIa is combined with more than one but less than two molar equivalents of XXiJa. [0156] In another example, the process is according to paragraph [0155], wherein XXIIa is combined with XXIa and said base in an aromatic solvent to form a mixture, and said mixture is heated to between about 100"C and 200"C for between about one and ten hours to form Ia. [01571 In another example, the process is according to paragraph [0156], wherein the aromatic solvent is an optionally substituted benzene. [0158] In another example, the process is according to paragraph [0157], wherein the aromatic solvent is bromobenzene. [0159] In another example, the process is according to paragraph [0158], wherein the base is 4-N,N-dimethylaminopyridine. 141 WO 2005/030140 PCT/US2004/031523 [0160] In another example, the process is according to paragraph [0159], wherein said mixture is heated to reflux for between about three and seven hours. [0161] In another example, the process is according to paragraph [0160], wherein said mixture is heated to reflux for between about four and six hours. [0162] In another example, the process is according to paragraph [0155], wherein XXIIa is combined with XXffla and said base in a non-aromatic solvent to form a mixture, and said mixture is heated to between about 40*C and 100*C for between about one and twenty hours to form XXIa. [0163] In another example, the process is according to paragraph [0162], wherein the non aromatic solvent comprises a functional group selected from an amide, and ether, a nitrile, a halide, an ester, an amine, and a ketone. [0164] In another example, the process is according to paragraph [0163], wherein the non aromatic solvent is NN-dimethylacetamide. [0165] In another example, the process is according to paragraph [0164], wherein the base is potassium carbonate. [0166] In another example, the process is according to paragraph [0165], wherein said mixture is heated to about 50"C between about ten and twenty hours. [0167] In another example, the process is according to paragraph [0166], wherein the aromatic solvent is an optionally substituted pyridine. [0168] In another example, the process is according to paragraph [0167], wherein the aromatic solvent is 2,6-lutidine. [0169] In another example, the process is according to paragraph (0168], wherein the base is 2,6-lutidine. ' [0170] In another example, the process is according to paragraph [0169], wherein said mixturee is heated to reflux for between about three and seven hours. [0171) In another example, the process is according to paragraph [01703, wherein said mixture is heated to reflux for between about four and six hours. [0172] In another example, the process is according to paragraph [0154], wherein one molar equivalent of XXIIa is combined with more than one but less than two molar equivalents of XXIIa. 142 WO 2005/030140 PCT/US2004/031523 [0173] In another example, the process is according to paragraph [0172], wherein XXIIa is combined with XXIIa and said base in an aromatic solvent to fonr a mixture, and said mixture is heated to between about 100"C and 200 0 C for between about ten and twenty hours to form XXIa. [0174] In another example, the process is according to paragraph [0173], wherein the aromatic solvent is an optionally substituted pyridine. [0175] In another example, the process is according to paragraph [0174], wherein the aromatic solvent is 2,6-lutidine. [0176] In another example, the process is according to paragraph [0175], wherein the base is 2,6-lutidine. [0177] In another example, the process is according to paragraph [0176], wherein said mixture is heated to between about 150*C and 200*C for between about fifteen and twenty hours. [0178] In another example, the process is according to any of paragraphs [0149] - [01771, wherein a compound of formula XXIb is substituted for the compound of formula XXHa, and either a compound of formula XXIIEh or a compound of formula XXILc is substituted for the compound of formula XXIa, in order to make a compound of formula XXMb or a compound of formula XXc, respectively, p1 R5Z< 0 N XXbb 1 4 33 N 1,J b XXN IN 0_4 WO 2005/030140 PCT/US2004/031523 N,) N ( R ) (R 2 I X XIc wherein J, R 50 , R 2 and R are as defined above. [0179] In another example, the process is according to paragraph '[0178], wherein R 2 , if present, is halogen. [0180] In another example, the process is according to paragraph [0179], wherein R 2 if present, is fluorine. [0181] In another example, the process is according to paragraph [0180], wherein R 2 , if present, is up to two fluorines ortho to the oxygen of the phenylene to which R 2 is attached. [0182] In another example, the process is according to paragraph [0130], used to make a compound listed in either Table 1 or Table 2. [0183] In another example the process is according to any of paragraphs [0130] - [0182], further comprising converting said compound to a pharmaceutically acceptable salt, hydrate, or prodrag thereof. Definitions [0184] As used in the present specification, the following words and phrases are, generally intended to have the meanings as set forth below, except to the extent that the context in 144 WO 2005/030140 PCT/US2004/031523 which they are used indicates otherwise or they are expressly defined to mean something different. [0185] The symbol "-" means a single bond, "=" means a double bond, "=" means a triple bond. The symbol "uvw" refers to a group on a double-bond as occupying either position on the terminus of a double bond to which the symbol is attached; that is, the geometry, E- or Z-, of the double bond is ambiguous. When a group is depicted removed from its parent formula, the "-~" symbol will be used at the end of the bond which was theoretically cleaved in order to separate the group from its parent structural formula. [0186] When chemical structures are depicted or described, unless explicitly stated otherwise, all carbons are assumed to have hydrogen substitution to conform to a valence of four. For example, in the structure on the left-hand side of the schematic below there are nine hydrogens implied. The nine hydrogen are depicted in the right-hand structure. Sometimes a particular atom in a structure is described in textual formula as having a hydrogen or hydrogens as substitution (expressly defined hydrogen), for example,

-CH

2 CH-. It is understood by one of ordinary sdll in the art that the aforementioned descriptive techniques are common in the chemical arts to provide brevity and simplicity to description of otherwise complex structures. H H H H IR BrBr O2-W~H H HH [0187] In this application, some ring structures are depicted generically and will be described textually. For example, in the schematic below, if in the structure on the left, ring A is used to describe a "spirocyclyl," then if ring A is cyclopropyl, there are at most four hydrogen on ring A (when "R" can also be -H). In another example, as depicted on the right side of the schematic below, if ring B is used to describe a "phenylene" then there can be at most four hydrogens on ring B (assuming depicted cleaved bonds are not C-H bonds). AB (0188] If a group "R" is depicted as floatingg" on a ring system, as for example in the formula: 145 WO 2005/030140 PCT/US2004/031523 then, unless otherwise defined, a substituent 'R" may reside on any atom of the ring system, assuming replacement of a depicted, implied, or expressly defined hydrogen from one of the ring atoms, so long as a stable structure is formed. [0189] If a group "R" is depicted as floating on a fused ring system, as for example in the formulae: or or then, unless otherwise defined, a substituent 'R"may reside on any atom of the fused ring system, assuming replacement of a depicted (for example the -NH- in the formula above), implied (for example as in the formula above, where the hydrogens are not shown but understood to be present), or expressly defined hydrogen (for example where in the formula above, "IC' equals =CH-) from one of the ring atoms, so long as a stable structure is formed. In the example depicted, the "R" group may reside on either the 5-membered or the 6-membered ring of the fused ring system. In the formula depicted above, when y is 2 for example, then the two "R's" may reside on any two atoms of the ring system, again assuming each replaces a depicted, implied, or expressly defined hydrogen on the ring. [0190] When there are more than one such depicted "floating" groups, as for example in the formulae: H R N R Ror R H , or or where there are two groups, namely, the '" and the bond indicating attachment to a parent structure; then, unless otherwise defined, the "floating" groups may reside on any atoms of the ring system, again assuming each replaces a depicted, implied, or expressly defined hydrogen on the ring. [0191] When a group "'" is depicted as existing on a ring system containing saturated carbons, as for example in the formula: 146 WO 2005/030140 PCT/US2004/031523 (R)y where, in this example, "y" can be more than one, assuming each replaces a currently depicted, implied, or expressly defined hydrogen on the ring; then, unless otherwise defined, where the resulting structure is stable, two "R's" may reside on the same carbon. A simple example is when R is a methyl group; there can exist a geminal dimethyl on a carbon of the depicted ring (an "annular" carbon). In another example, two R's on the same carbon, including that carbon, may form a ring, thus creating a spirocyclic ring (a "spirocyclyl" group) structure with the depicted ring as for example in the formula: HNJO [0192] "Alkyl" is intended to include linear, branched, or cyclic hydrocarbon structures and combinations thereof, inclusively. For example, "Cs alIkyl" may refer to an n-octyl, iso-octyl, cyclohexylethyl, and the like. Lower alkyl refers to alkyl groups of from one to six carbon atoms. Examples of lower alkyl groups include methyl, ethyl, propyl, isopropyl, butyl, s-butyl, t-butyl, isobutyl, pentyl, hexyl and the like. Higher alkyl refers to ailcyl groups containing more that eight carbon atoms. Exemplary alkyl groups are those of C20 or below. Cycloalkyl is a subset of alIyl and includes cyclic hydrocarbon groups of from three to thirteen carbon atoms. Examples of cycloalkyl groups include c propyl, c-butyl, c-pentyl, norbomyl, adamantyl and the like. In this application, alkyl refers to alkanyL alkenyl, and alkynyl residues (and combinations thereof); it is intended to include cyclohexylmethyl, vinyl, allyl, isoprenyl, and the like. Thus when an allcyl residue having a specific number of carbons is named, all geometric isomers having that number of carbons are intended to be encompassed; thus, for example, either "butyl" or "C4 alkyl" is meant to include n-butyl, sec-butyl, isobutyl, t-butyl, isobutenyl and but-2 yne radicals; and for example, propyll" or "03 alkyr' each include n-propyl, propenyl, and isopropyl. [0193] "Alkylene" refers to straight or branched chain divalent radical consisting solely of carbon and hydrogen atoms, containing no unsaturation and having from one to ten carbon atoms, for example, methylene, ethylene, propylene, n-butylene and the like. Alkylene is a subset of alkyl, referring to the same residues as alkyl, but having two points of attachment and, specifically, fully saturated. Examples of alkylene include ethylene 147 WO 2005/030140 PCT/US2004/031523

(-CH

2

CH

2 -), propylene (-CH 2

CH

2

CH

2 -), dimethyipropylene (-CH 2 C(CH3) 2

CH

2 -), and cyclohexyipropylene (-CH2CH 2 CH(CaH 3 )). [0194] "Alkylidene" refers to a straight or branched chain unsaturated divalent radical consisting solely of carbon and hydrogen atoms, having from two to ten carbon atoms, for example, -ethylidene, propylidene, n-butylidene, and the like. Alkylidene is a subset of alkyl, referring to the same residues as alkyl, but having two points of attachment and, specifically, double bond unsaturation. The unsaturation present includes at least one double bond. [0195] "Alkylidyne" refers to a straight or branched chain unsaturated divalent radical consisting solely of carbon and hydrogen atoms having from two to ten carbon atoms, for example, propylid-2-ynyl, n-butylid-1-ynyl, and the like. Alkylidyne is a subset of alkyl, referring to the same residues as alkyl, but having two points of attachment and, specifically, triple bond unsaturation. The unsaturation present includes at least one triple bond. [0196] Any of the above radicals, "alkylene," "alkylidene" and "alkylidyne," when optionally substituted, may contain alkyl substitution which itself contains unsaturation. For example, 2-(2-phenylethynyl-but-3-enyl)-naphthalene (IUPAC name) contains an n-butylid-3-ynyl radical with a vinyl substituent at the 2-position of said radical. [01973 "Alkoxy" or "alkoxyl" refers to the group -0-alkyl, for example including from one to eight carbon atoms of a straight, branched, cyclic configuration, unsaturated chains, and combinations thereof attached to the parent structure through an oxygen atom. Examples include methoxy, ethoxy, propoxy, isopropoxy, cyclopropyloxy, cyclohexyloxy and the like. Lower-alkoxy refers to groups containing one to six carbons. [0198] "Substituted alkoxy" refers to the group -0-(substituted alkyl), the substitution on the alkyl group generally containing more than only carbon (as defined by alkoxy). One exemplary substituted alkoxy group is "polyalkoxy" or -0-optionally substituted alkylene-optionally substituted alkoxy, and includes groups such as -OCH 2

CH

2 0CH 3 , and glycol ethers such as polyethyleneglycol and -O(CH2CH20),CH 3 , where x is an integer of between about two and about twenty, in another example, between about two and about ten, and in a further example between about two and about five. Another exemplary substituted alkoxy group is hydroxyalkoxy or -OCH2(CH 2 )yOH, where y is for example an 148 WO 2005/030140 PCT/US2004/031523 integer of between about one and about ten, in another example y is an integer of between about one and about four. [0199] "Acyl" refers to groups of from one to ten carbon atoms of a straight, branched, cyclic configuration, saturated, unsaturated and aromatic and combinations thereof, attached to the parent structure through a carbonyl functionality. One or more carbons in the acyl residue may be replaced by nitrogen, oxygen or sulfur as long as the point of attachment to the parent remains at the carbonyl. Examples include acetyl, benzoyl, propionyl, isobutyryl, t-butoxycarbonyl, benzyloxycarbonyl and the like. Lower-acyl refers to groups containing one to six carbons. [0200] "a-Amino Acids" refer to naturally occurring and commercially available amino acids and optical isomers thereof. Typical natural and commercially available a-amino acids are glycine, alanine, series, homoserine, threonine, valine, norvaline, leucine, isoleucine, norleucine, aspartic acid, glutamic acid, lysine, omithine, histidine, arginine, cysteine, homocysteine, methionine, phenylalanine, homophenylalanine, phenylglycine, ortho-tyrosine, meta-tyrosine, para-tyrosine, tryptophan, glutamine, asparagine, proline and hydroxyproline. A "side chain of an a-amino acid" refers to the radical found on the a-carbon of an a-amino acid as defined above, for example, hydrogen (for glycine), methyl (for alanine), benzyl (for phenylalanine), and the like. 10201] "Amino" refers to the group -NH 2 . "Substituted amino," refers to the group -N(H)R or -N(R)R where each R is independently selected from the group: optionally substituted alkyl, optionally substituted alkoxy, optionally substituted aryl, optionally substituted heterocyclyl, acyl, carboxy, alkoxycarbonyl, sulfanyl, sulfinyl and sulfonyl, for example, diethylamino, methylsulfonylamino, furanyl-oxy-sulfonamino. [0202] "Asyl" refers to aromatic six- to fourteen-membered carbocyclic ring, for example, benzene, naphthalene, indane, tetralin, fluorene and the like, univalent radicals. As univalent radicals, the aforementioned ring examples are named, phenyl, naphthyl, indanyl, tetralinyl, and fluorenyl. [0203] "Arylene" generically refers to any aryl that has at least two groups attached thereto. For a more specific example, "phenylene" refers to a divalent phenyl ring radical. A phenylene, thus may have more than two groups attached, but is defined by a minimum of two non-hydrogen groups attached themto. 149 WO 2005/030140 PCT/US2004/031523 {0204] "Arylalkyl" refers to a residue in which an aryl moiety is attached to a parent structure via one of an alkylene, alkylidene, or alkylidyne radical. Examples include benzyl, phenethyl, phenylvinyl, phenylallyl and the like. Both the aryl, and the corresponding alkylene, alkylidene, or alkylidyne radical portion of an arylalkyl group may be optionally substituted. "Lower arylalkyr' refers to an arylalkyl where the "alkyl" portion of the group has one to six carbons; this can also be refered to as C6 arylalkyl. [0205] "Exo-alkenyl" refers to a double bond that emanates from an annular carbon, and is not within the ring system, for example the double bond depicted in the formula below. 0 0 (0206] In some examples, as appreciated by one of ordinary skill in the art, two adjacent groups on an aromatic system may be fused together to form a ring structure. The fused ring structure may contain heteroatoms and may be optionally substituted with one or more groups. It should additionally be noted that saturated carbons of such fused groups (i.e. saturated ring structures) can contain two substitution groups. [0207] "Fused-polycyclic" or "fused ring system" refers to a polycycic ring system that contains bridged or fused rings; that is, where two rings have more than one shared atom in their ring structures. In this application, fused-polycyclics and fused ring systems are not necessarily all aromatic ring systems. Typically, but not necessarily, fused-polycyclics share a vicinal set of atoms, for example naphthalene or 1,2,3,4-tetrahydro-naphthalene. A spiro ring system is not a fused-polycyclic by this definition, but fused polycyclic ring systems of the invention may themselves have spiro rings attached thereto via a single ring atom of the fused-polycyclic. (0208] "Halogen" or "halo" refers to fluorine, chlorine, bromine or iodine. "Haloalkyl" and "haloaryl" refer generically to alkyl and aryl radicals that are substituted with one or more halogens, respectively. Thus, "dihaloaryl," "dihaloalkyl," "trihaloaryl" etc. refer to aryl and alkyl substituted with a plurality of halogens, but not necessarily a plurality of the same halogen; thus 4-chloro-3-luorophenyl is within the scope of dihaloaryl. [0209] "Heteroarylene" generically refers to any heteroaryl that has at least two groups attached thereto. For a more specific example, "pyridylene" refers to a divalent pyridyl 150 WO 2005/030140 PCT/US2004/031523 ring radical. A pyridylene, thus may have more than two groups attached, but is defined by a minimum of two non-hydrogen groups attached thereto. [0210] "Heteroatom" refers to 0, S, N, or P. [0211] "Heterocyclyl" refers to a stable three- to fifteen-membered ring radical that consists of carbon atoms and from one to five heteroatoms selected from the group consisting of nitrogen, phosphorus, oxygen atid sulfur. For purposes of this invention, the heterocyclyl radical may be a monocyclic, bicyclic or tricyclic ring system, which may include fused or bridged ring systems as well as spirocycic systems; and the nitrogen, phosphorus, carbon or sulfur atoms in the heterocyclyl radical may be optionally oxidized to various oxidation states. In a specific example, the group -S(0)o-2-, refers to -S (sulfide), -S(O)- (sulfoxide), and -So2- (sulfone). For convenience, nitrogens, particularly but not exclusively, those defined as annular aromatic nitrogens, are meant to include their corresponding N-oxide form, although not explicitly defined as such in a particular example. Thus, for a compound of the invention having, for example, a pyridyl ring; the corresponding pyridyl-N-oxide is meant to be included as another compound of the invention. In addition, annular nitrogen atoms may be optionally quaternized; and the ring radical may be partially or fully saturated or aromatic. Examples of heterocyclyl radicals include, but are not limited to, azetidinyl, acridinyl, benzodioxolyl, benzodioxanyl, benzofuranyl, carbazoyl, cinnolinyl, dioxolanyl, indolizinyl, naphthyridinyl, perhydroazepinyl, phenazinyl, phenothiazinyl, phenoxazinyl, phthalazinyl, pteridinyl, purinyl, quinazolinyl, quinoxalinyl, quinolinyl, isoquinolinyl, tetrazoyl. tetrahydroisoquinolyl, piperidinyl, piperazinyl, 2-oxopiperazinyl, 2-oxopiperidiny 7 2-oxopyrrolidinyl, 2-oxoazepinyl, azepinyl, pyrrolyl, 4-piperidonyl, pyrrolidinyl, pyrazolyl, pyrazolidinyl, imidazolyl, imidazolinyl, imidazolidinyl, dihydropyridinyl, tetrahydropyidinyl, pyridinyl, pyrazinyl, pyrimidinyl, pyridazinyl, oxazolyl, oxazolinyl, oxazolidinyl, triazolyl, isoxazolyl, isoxazolidinyl, morpholinyl, thiazolyl, thiazolinyl, thiazolidinyl, isothiazolyl, quinuclidinyl, isothiazolidinyl, indolyl, isoindolyl, indolinyl, isoindolinyl, octahydroindolyl, octahydroisoindolyl, quinolyl, isoquinolyl, decahydroisoquinolyl, benzimidazolyl, thiadiazolyl, benzopyranyl, benzothiazolyL benzoxazolyl, furyl, tetrahydrofuryl, tetrahydropyranyl, thienyl, benzothieliyl, thiamorpholinyl, thiamorpholinyl sulfoxide, thiamorpholinyl sulfone, dioxaphospholanyl, and oxadiazolyl. 151 WO 2005/030140 PCT/Us204/031523 [02121 "Ietemalicyclic" refers specifically to a non-aromatic heterocyclyl radical. A heteroalicyclic may contain unsaturation, but is not aromatic. [0213] "Heteroaryl" refers specifically to an aromatic heterocyclyl radical. [0214] "Heterocyclylalkyl" refers to a residue in which a heterocyclyl is attached to a parent structure via one of an alkylene, alkylidene, or alkylidyne radical. Examples include (4-methylpiperazin-1-yl) methyl, (morpholin-4-yl) methyl, (pyridine-4-yl) methyl, 2-(oxazolin-2-yl) ethyl, 4-(4-methylpiperazin-1-yl)2-butenyl, and the like. Both the heterocyclyl, and the corresponding alkylene, alkylidene, or alkylidyne radical portion of a heterocyclylalkyl group may be optionally substituted. "Lower heterocyclylalkyl" refers to a heterocyclylalkyl where the "alkyl" portion of the group has one to six carbons. "Heteroalicyclylalkyl" refers specifically to a heterocyclylalkyl where the heterocyclyl portion of the group is non-aromatic; and "heteroarylalkyl" refers specifically to a heterocyclylalkyl where the heterocyclyl portion of the group is aromatic Such terms may be described in more than one way, for example, "lower heterocyclylalkyl" and "heterocyclyl CI6akyI" are equivalent terms. [0215] "Optional" or "optionally" means that the subsequently described event or circumstance may or may not occur, and that the description includes instances where said event or circumstance occurs and instances in which it does not. One of ordinary skill in the art would understand that, with respect to any molecule described as containing one or more optional substituents, that only stoically practical and/or synthetically feasible compounds are meant to be included. "Optionally substituted" refers to all subsequent modifiers in a term, for example in the term "optionally substituted arylC..s alkyl," optional substitution may occur on both the "C.. alkyl" portion and the "aryl" portion of the molecule; and for example, optionally substituted alkyl includes optionally substituted cycloalkyl groups, which in tum are defined as including optionally substituted alkyl groups, potentially ad infinium. A list of exemplary optional substitution are listed below in the definition of "substituted." [0216] "Saturated bridged ring system" refers to a bicyclic or polycyclic ring system that is not aromatic. Such a system may contain isolated or conjugated unsaturation, but not aromatic or heteroaromatic rings in its core structure (but may have aromatic substitution thereon). For example, hexahydro-furo[3,2-b]furan, 2,3,3a,4,7,7a-hexahydro-IR-indene, 7-aza-bicyclo[2.2.1]heptane, and 1,2,3,4,4a,5,8,8a-dctahydro-naphthalene are all included in the class "saturated bridged ring system." 152 WO 2005/030140 PCT/US2004/031523 [0217] "Spirocyclyl" or "spirocyclic ring" refers to a ring originating from a particular annular carbon of another ring. For example, as depicted below, a ring atom of a saturated bridged ring system (rings B and B'), but not a bridgehead atom, can be a shared atom between the saturated bridged ring system and a spirocyclyl (ring A) attached thereto. A spirocyclyl can be carbocyclic or heteroalicyclic. B B' [0218] "Substituted" alkyl, aryl, and heterocyclyl, refer respectively to alkyl, aryl, and heterocyclyl, wherein one or more (for example up to about five, in another example, up to about three) hydrogen atoms are replaced by a substituent independently selected from optionally substituted alkyl (for example, fluoromethyl), optionally substituted aryl (for example, 4-hydroxyphenyl), optionally substituted arylalkyl (for example, 1-phenyl-ethyl), optionally substituted heterocyclylalkyl (for example, 1-pyridin-3-yl-ethyl), optionally substituted heterocyclyl (for example, 5-chloro-pyridin-3-yl or 1-methyl-piperidin-4-yl), optionally substituted alkoxy, alkylenedioxy (for example methylenedioxy), optionally substituted amino (for example, alkylamino and dialkylamino), optionally substituted amidino, optionally substituted aryloxy (for example, phenoxy), optionally substituted arylalkyloxy (for example, benzyloxy), carboxy (-COH), carboalkoxy (that is, acyloxy or -OC(=O)R), carboxyalkyl (that is, esters or -CO 2 R), carboxamido, benzyloxycarbonylamino (CBZ-amino), cyano, acyl, halogen, hydroxy, nitro, sulfanyl, sulfinyl, sulfonyl, thiol, halogen, hydroxy, oxo, carbamyl, acylamino, and siilfonamido. [0219] "Suitable leaving group" is defined as the term would be understood by one of ordinary skill in the art; that is, a carbon with such a group attached, upon reaction wherein a new bond is to be formed, loses such a group upon formation of the new bond. The invention pertains particularly with respect convergent synthesis, to reactions where such a. leaving group is bonded to a reaction partner that is aromatic, undergoes a bond forming reaction and remains aromatic. A typical example of such a reaction is a nucleophilic aromatic substitution reaction, as would be understood by one of ordinary skill in the art. However, the invention is not limited to such mechanistic restrictions; for example, reactions where there is, for example, an insertion reaction (for example by a transition metal) into the bond between the aromatic reaction partner and its leaving group 153 WO 2005/030140 PCT/US2004/031523 followed by reductive coupling can also be used within the scope of the invention. Examples of suitable leaving groups include halogens, optionally substituted aryl or alkyl sulfonates, phosphonates, azides, RS(O)o 2 - where R Is, for example optionally substituted alkyl, optionally substituted aryl, or optionally substituted heteroaryl. [0220] "Sulfanyl" refers to the groups: -S-(optionally substituted alkyl), -S-(optionally substituted aryl), and -S-(optionally substituted heterocyclyl). [0221] "Sulfinyl" refers to the groups: -S(O)-H, -S(O)-(optionally substituted alkyl), -S(O)-optionally substituted aryl), and -S(O)-(optionally substituted heterocyclyl). [0222] "Sulfonyl" refers to the groups: -S(0 2 )-H, -S(0 2 )-(optionally substituted alkyl), -S(O2)-optionally substituted aryl), -S(02)-(optionally substituted heterocyclyl), -S(O2)-(optionally substituted alkoxy), -S(02)-optionally substituted aryloxy), and -S(O2)-(optionally substituted heterocyclyloxy). [0223] "Yield" for each of the reactions described herein is expressed as percentage of the theoretical yield. [0224] Some of the compounds of the invention may have imino, amino, oxo or hydroxy substituents off aromatic heterocyclyl systems. For purposes of this disclosure, it is understood that such imino, amino, oxo or hydroxy substituents may exist in their corresponding tautomeric form, i.e., amino, imino, hydroxy or oxo, respectively. [0225] Compounds of the invention are named according to systematic application of the nomenclature rules agreed upon by the International Union of Pure and Applied Chemistry (IUPAC), International Union of Biochemistry and Molecular Biology (IUBMB), and the Chemical Abstracts Service (CAS). [0226] The compounds of the invention, or their pharmaceutically acceptable salts, may have asymmetric carbon atoms, oxidized sulfur atoms or quaternized nitrogen atoms in their structure. 10227 The compounds of the invention and their pharmaceutically acceptable salts may exist as single stereoisomers, racemates, and as mixtures of enantiomers and diastereomers. The compounds may also exist as geometric isomers. All such single stereoisoners, racemates and mixtures thereof, and geometric isomers are intended to be within the scope of this invention. 154 WO 20051030140 PCT/US2004/031523 [0228] It is assumed that when considering generic descriptions of compounds of the invention for the purpose of constructing a compound, such construction results in the creation of a table structure. That is, one of ordinary sldl in the art would recognize that there can theoretically be some constructs which would not normally be considered as stable compounds (that is, sterically practical and/or synthetically feasible, supra). [0229] When a particular group with its bonding structure is denoted as being bonded to two partners; that is, a divalent radical, for example, -OCH 2 -, then it is understood that either of the two partners may be bound to the particular group at one end, and the other partner is necessarily bound to the other end of the particular group, unless stated explicitly otherwise. Stated another way, divalent radicals are not to be construed as limited to the depicted orientation, for example "-OC] 1 2-" is meant to mean not only

"-OC

2 -" as drawn, but also "-CH20-." [0230] Methods for the preparation and/or separation and isolation of single stereoisomers from racemic mixtures or non-racemic mixtures of stereoisomers are well known in the art. For example, optically active (R)- and (S)- isomers may be prepared using chiral synthons or chiral reagents, or resolved using conventional techniques. Enantiomers (R and S-isomers) may be resolved by methods known to one of ordinary skill in the art, for example by: formation of diastereoisomeric salts or complexes which may be separated, for example, by crystallization; via formation of diastereoisomeric derivatives which may be separated, for example, by crystallization, selective reaction of one enantiomer with an enantiomer-specific reagent, for example enzymatic oxidation or reduction, followed by separation of the modified and unmodified enantiomers; or gas-liquid or liquid chromatography in a chiral environment, for example on a chiral support, such as silica with a bound chiral ligand or in the presence of a chiral solvent. It will be appreciated that where a desired enantiomer is converted into another chemical entity by one of the separation procedures described above, a further step may be required to liberate the desired enantiomeric form. Alternatively, specific enantiomer may be synthesized by asymmetric synthesis using optically active reagents, substrates, catalysts or solvents, or by converting on enantiomer to the other by asymmetric transformation. For a mixture of enantiomers, enriched in a particular enantiomer, the major component enantiomner may be further enriched (with concomitant loss in yield) by recrystallization. [0231] "Patient" for the purposes of the present invention includes humans and other animals, particularly mammals, and other organisms. Thus the methods are applicable to 155 WO 2005/030140 PCT/US2004/031523 both human therapy and veterinary applications. In a preferred embodiment the patient is a mammal, and in a most preferred embodiment the patient is human. [0232] "Kinase-dependent diseases or conditions" refer to pathologic conditions that depend on the activity of one or more protein Idnases. Kinases either directly or indirectly participate in the signal transduction pathways of a variety of cellular activities including proliferation, adhesion, migration, differentiation and invasion. Diseases associated with Idnase activities include tumor growth, the pathologic neovascularization that supports solid tumor .growth, and associated with other diseases where excessive local vascularization is involved such as ocular diseases (diabetic retinopathy, age-related macular degeneration, and the like) and inflammation (psoriasis, rheumatoid arthritis, and the like). [0233] While not wishing to be bound to theory, phosphatases can also play a role in "Iinase-dependent diseases or conditions" as cognates of kinases; that is, kinases phosphorylate and phosphatases dephosphorylate, for example protein substrates. Therefore compounds of the invention, while modulating linase activity as described herein, may also modulate, either directly or indirectly, phosphatase activity. This additional modulation, if present, may be synergistic (or not) to activity of compounds of the invention toward a related or otherwise interdependent kinase or kinase family. In any case, as stated previously, the compounds of the invention are useful for treating diseases characterized in part by abnormal levels of cell proliferation (i.e. tumor growth), programmed cell death (apoptosis), cell migration and invasion and anglogenesis associated with tumor growth. [0234] "Therapeutically effective amount" is an amount of a compound of the invention, that when administered to a patient, ameliorates a symptom of the disease. The amount of a compound of the invention which constitutes a "therapeutically effective amount" will vary depending on the compound, the disease state and its severity, the age of the patient to be treated, and the like. The therapeutically effective amount can be determined routinely by one of ordinary skill in the art having regard to his own knowledge and to this disclosure. [0235] "Cancer" refers to cellular-proliferative disease states, including but not limited to: Cardiac: sarcoma (angiosarcoma, fibrosarcoma, rhabdomyosarcoma, liposarconia), myxoma, rhabdomyoma, fibroma, lipoma and teratoma; Lung;: bronchogenic carcinoma (squamous cell, undifferentiated small cell, undifferentiated large cell, adenocarcinoma), 156 WO 20051030140 PCT/US2004/031523 alveolar (bronchiolar) carcinoma, bronchial adenoma, sarcoma, lymphoma, chondromatous hanlartoma, inesothelioma; Gastrointestinal: esophagus (squamous cell carcinoma, adenocarcinoma, leiomyosaxtoma, lymphoma), stomach (carcinoma, lymphoma, leiomyosarcoma), pancreas (ductal adenocarcinoma, insulinorna, glucagonoma, gastrinoma, carcinoid tumors, vipoma), small bowel (adenocarcinorna, lymphoma, carcinoid tumors, Karposi's sarcoma, leiomyoma, hemangloma, liporma, neurofibroma, fibroma), large bowel (adenocaivinoma, tubular adenoma, villous adenoma, hamartoma, leiomyoma); Genitourinary tract: kidney (adenocatcinoma, Wilm's tumor [nepIrroblastoma], lymphoma, leukemia), bladder and urethra (squamous cell carcinoma, transitional cell carcinoma, adenocarcinoma), prostate (adenocarcinoma, sarcoma), testis (seminoma, teratoma, embryonal carcinoma, teratocarcinoma, choriocarcinoma, sarcorna, interstitial cell carcinoma, fibroma, fibroadenoma, adenomatoid tumors, lipoma); _Liver: hepatoma (hepatocellular carcinoma), cholangiocarcinoma, hepatoblastorna, angiosarcoma, hepatocellular adenoma, hemangioma; Blong: osteogenic sarcoma osteosarcomaa), fibrosarcoma, malignant fibrous histiocytoma, chondrosarcoma, Ewing's sarcoma, malignant lymphoma (reticulum cell sarcoma), multiple myeloma, malignant giant cell tumor chordoma, osteochronfroma (osteocartilaginous exostoses), benign chondroma, chondroblastoma, chondromyxofibroma, osteoid osteoma and giant cell tumors; Nervous system: skull (osteoma, hemangioma, granuloma, xanthoma, osteitis defornians), meninges (meningioma, meningiosarcoma, gliomatosis), brain (astrocytona, medulloblastoma, glioma, ependymoma, germinoma [pinealoma], glioblastorna multiform, oligodendroglioma, schwannoma, retinoblastoma, congenital tumors), spinal cord neurofibroma, meningioma, glioma, sarcoma); Gynecological: uterus (endometrial carcinoma), cervix (cervical carcinoma, pre-tumor cervical dysplasia), ovaries (ovarian carcinoma [serous cystadenocarcinoma, mucinous cystadenocarcinoma, - unclassified carcinoma], granulosa-thecal cell tumors, SertoliLeydig cell tumors, dysgerminona, malignant teratoma), vulva (squamous cell carcinoma, intraepithelial carcinoma, sdenocarcinoma, fibrosarcoma, melanoma), vagina (clear cell carcinoma, squamous cell carcinoma, botryoid sarcoma (embryonal rhabdomyosarcoma], fallipian tubes (carcinoma); H&matologic: blood myeloidd leukemia [acute and chronic], acute lymphoblastic leukemia, chronic lymphocytic leukemia, myeloproliferative diseases, multiple myeloma, myelodysplastic syndrome), Hodgkin's disease, non-fHodgkn's lymphoma [malignant lymphoma]; Sjkin: malignant melanoma, basal cell carcinoma, squamous cell carcinoma, Karposi's sarcoma, moles dysplastic nevi, lipoma, angioPa, 157 WO 2005/030140 PCT/JS2004/031523 dennatofibroma, keloids, psoriasis; and Adrenal lands: neuroblastoma. Thus, the term "cancerous cell" as provided herein, includes a cell afflicted by any one of the above-identified conditions. [0236] "Pharmaceutically acceptable acid addition salt" refers to those salts that retain the biological effectiveness of the free bases and that are not biologically or otherwise undesirable, formed with inorganic acids such as hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid, and the like, as well as organic acids such as acetic acid, trifluoroacetic acid, propionic acid, glycolic acid, pyruvic acid, oxalic acid, maleic acid, malonic acid, succinic acid, fumaric acid, tartaric acid, citric acid, benzoic acid, cinnamic acid, mandelic acid, methanesulfonic acid, ethanesulfonic acid, p-toluenesulfonic acid, salicylic acid and the like. [0237] "Pharmaceutically acceptable base addition salts" include those derived from inorganic bases such as sodium, potassium, lithium, ammonium, calcium, magnesium, iron, zinc, copper, manganese, aluminum salts and the like. Exemplary salts are the ammonium, potassium, sodium, calcium, and magnesium salts. Salts derived from pharmaceutically acceptable organic non-toxic bases include, but are not limited to, salts of primary, secondary, and tertiary amines, substituted amines including naturally occurring substituted amines, cyclic amines and basic ion exchange resins, such as isopropylamine, trimethylamine, diethylamine, triethylamine, tripropylamine, ethanolamine, 2-dimethylaminoethanol, 2-diethylaminoethanol, dicyclohexylamine, lysine, arginine, histidine, caffeine, procaine, hydrabamine, choline, betaine, ethylenediamine, glucosamine, methylglucamine, theobromine, purines, piperazine, piperidine, N-ethylpiperidine, polyamine resins, and the like. Exemplary organic bases are isopropylamine, diethylamine, ethanolamine, trimethylamine, dicyclohexylamine, choline, and caffeine. (See, for example, S. M. Berge, et al., "Pharmaceutical Salts," J. Pharm. Sci., 1977;66:1-19 which is incorporated herein by reference.) [0238] "Prodrug" refers to compounds that are transformed (typically rapidly) in vivo to yield the parent compound of the above formulae, for example, by hydrolysis in blood. Common examples include, but are not limited to, ester and amide forms of a compound having an active form beating a carboxylic acid moiety. Examples of pharmaceutically acceptable esters of the compounds of this invention include, but are not limited to, alkyl esters (for example with between about one and about six carbons) wherein the alkyl group is a straight or branched chain. Acceptable esters also include cycloalkyl esters and 158 WO 2005/030140 PCT/US20041031523 arylalkyl esters such as, but not limited to benzyl. Examples of pharmaceutically acceptable amides of the compounds of this invention include, but are not limited to, primary amides, and secondary and tertiary alkyl aides (for example with between about one and about six carbons). Amides and esters of the compounds of the present invention may be prepared according to conventional methods. A thorough discussion of prodrugs is provided in T. Higuchi and V. Stella, "ro-drugs as Novel Delivery Systems," Vol 14 of the A.C.S. Symposium Series, and in Bioreversible Cariers in Drug Design, ed. Edward B. Roche, American Pharmaceutical Association and Pergamon Press, 1987, both of which are incorporated herein by reference for all purposes. [0239] "Metabolite" refers to the break-down or end product of a compound or its salt produced by metabolism or biotransformation in the animal or human body; for example, biotransformation to a more polar molecule such as by oxidation, reduction, or hydrolysis, or to a conjugate (see Goodman and Gilman, "The Pharmacological Basis of Therapeutics" 8.sup.th Ed., Pergamon Press, Gilman et al. (eds), 1990 for a discussion of biotransformation). As used herein, the metabolite of a compound of the invention or its salt may be the biologically active form of the compound in the body. In one example, a prodrug may be used such that the biologically active form, a metabolite, is released in vivo. In another example, a biologically active metabolite is discovered serendipitously, that is, no prodrug design per se was undertaken. An assay for activity of a metabolite of a compound of the present invention is known to one of skill in the art in light of the present disclosure. [0240] In addition, the compounds of the present invention can exist in unsolvated as well as solvated forms with pharmaceutically acceptable solvents such as water, ethanol, and the like. In general, the solvated forms are considered equivalent to the unsolvated forms for the purposes of the present invention. [0241] In addition, it is intended that the present invention cover compounds made either using standard organic synthetic techniques, including combinatorial chemistry or by biological methods, such as bacterial digestion, metabolism, enzymatic conversion, and the like. [0242] "Treating" or "treatment" as used herein covers the treatment of a disease-state in a human, which disease-state is characterized by abnormal cellular proliferation, and invasion and includes at least one of: (i) preventing the disease-state from occurring in a human, in particular, when such human is predisposed to the disease-state but has not yet 159 WO 2005/030140 PCT/US2004/031523 been diagnosed as having it; (ii) inhibiting the disease-stat, i.e., arresting its development; and (iii) relieving the disease-state, i.e., causing regression of the disease-state. As is known in the an, adjustments for systemic versus localized delivery, age, body weight, general health, sex, diet, time of administration, drug interaction and the severity of the condition may be necessary, and will be ascertainable with routine experimentation by one of ordinary skill in the art. [0243] One of ordinary skill in the art would understand that certain crystallized, protein ligand complexes, in particular c-Met, c-Kit, KDR, fit-3, or flt-4-ligand complexes, and their corresponding x-ray structure coordinates can be used to reveal new structural information useful for understanding the biological activity of kinases as described herein. As well, the key structural features of the aforementioned proteins, particularly, the shape of the ligand binding site, are useful in methods for designing or identifying selective modulators of kinases and in solving the structures of other proteins with similar features. Such protein-ligand complexes, having compounds of the invention as their ligand component, are an aspect of the invention. [0244] As well, one of ordinary skill in the art would appreciate that such suitable x-ray quality crystals can be used as part of a method of identifying a candidate agent capable of binding to and modulating the activity of kinases. Such methods may be characterized by the following aspects: a) introducing into a suitable computer program, information defining a ligand binding domain of a kinase in a conformation (e.g. as defined by x-ray structure coordinates obtained from suitable x-ray quality crystals as described above) wherein the computer program creates a model of the three dimensional structures of the ligand binding domain, b) introducing a model of the three dimensional structure of a candidate agent in the computer program, c) superimposing the model of the candidate agent on the model of the ligand binding domain, and d) assessing whether the candidate agent model fits spatially into the ligand binding domain. Aspects a-d are not necessarily carried out in the aforementioned order. Such methods may further entail: performing rational drag design with the model of the three-dimensional structure, and selecting a potential candidate agent in conjunction with computer modeling. (0245] Additionally, one skilled in the art would appreciate that such methods may further entail: employing a candidate agent, so-determined to fit spatially into the ligand binding domain, in a biological activity assay for Idnase modulation, and determining whether said candidate agent modulates kinase activity in the assay. Such methods may also include 160 WO 2005/030140 PCTUS2004/031523 administering the candidate agent, determined to modulate kinase activity, to a mammal suffering from a condition treatable by Idnase modulation, such as those described above. [0246] Also, one skilled in the art would appreciate that compounds of the invention can be used in a method of evahdating the ability of a test agent to associate with a molecule or molecular complex comprising a ligand binding domain of a kinase. Such a method may be characterized by the following aspects: a) creating a computer model of a Idnase binding pocket using structure coordinates obtained from suitable x-ray quality crystals of the inase, b) employing computational algorithms to perform a fitting operation between the test agent and the computer model of the binding pocket, and c) analyzing the results of the fitting operation to quantify the association between the test agent and the computer model of the binding pocket. General Administration [0247] Administration of the compounds of the invention, or their pharmaceutically acceptable salts, in pure form or in an appropriate pharmaceutical composition, can be carried out via any of the accepted modes of administration or agents for serving similar utilities. Thus, administration can be, for example, orally, nasally, parenterally (intravenous, intramuscular, or subcutaneous), topically, transdermally, intravaginally, intravesically, intracistemally, or rectally, in the form of solid, semi-solid, lyophilized powder, or liquid dosage forms, such, as for example, tablets, suppositories, pills, soft elastic and hard gelatin capsules, powders, solutions, suspensions, or aerosols, or the lite, preferably in unit dosage forms suitable for simple administration of precise dosages. [0248] The compositions will include a conventional pharmaceutical carrier or excipient and a compound of the invention as the/an active agent, and, in addition, may include other medicinal agents, pharmaceutical agents, carriers, adjuvants, etc. Compositions of the invention may be used in combination with anticancer or other agents that are generally administered to a patient being treated for cancer. Adjuvants include preserving, wetting, suspending, sweetening, flavoring, perfuming, emulsifying, and dispensing agents. Prevention of the action of microorganisms can be ensured by various antibacterial and antifungal agents, for example, parabens, chlorobutanol, phenol, sorbic acid, and the like. It may also be desirable to include isotonic agents, for example sugars, sodium chloride, and the like. Prolonged absorption of the injectable pharmaceutical form 161 WO 2005/030140 PCT/US2004/031523 can be brought about by the use of agents delaying absorption, for example, aluminum monostearate and gelatin. [0249] If desired, a pharmaceutical composition of the invention may also contain minor amounts of auxiliary substances such as wetting or emulsifying agents, pH buffering agents, antioxidants, and the like, such as, for example, citric acid, sorbitan monolaurate, triethanolamine oleate, butylalted hydroxytoluene, etc. [0250] Compositions suitable for parenteral injection may comprise physiologically acceptable sterile aqueous or nonaqueous solutions, dispersions, suspensions or emulsions, and sterile powders for reconstitution into sterile injectable solutions or dispersions. Examples of suitable aqueous and nonaqueous carriers, diluents, solvents or vehicles idelude water, ethanol, polyols (propyleneglycol, polyethyleneglycol, glycerol, and the like), suitable mixtures thereof, vegetable oils (such as olive oil) and injectable organic esters such as ethyl oleate. Proper fluidity can be maintained, for example, by the use of a coating such as lecithin, by the maintenance of the required particle size in the case of dispersions and by the use of surfactants. [0251] One preferable route of administration is oral, using a convenient daily dosage regimen that can be adjusted according to the degree of severity of the disease-state to be treated. [0252] Solid dosage forms for oral administration include capsules, tablets, pills, powders, and granules. In such solid dosage forms, the active compound is admixed with at least one inert customary excipient (or carrier) such as sodium citrate or dicalcium phosphate or (a) fillers or extenders, as for example, starches, lactose, sucrose, glucose, mannitol, and silicic acid, (b) binders, as for example, cellulose derivatives, starch, alignates, gelatin, polyvinylpyrrolidone, sucrose, and gum acacia, (c) humectants, as for example, glycerol, (d) disintegrating agents, as for example, agar-agar, calcium carbonate, potato or tapioca starch, alginic acid, croscarmellose sodium, complex silicates, and sodium carbonate, (e) solution retarders, as for example paraffin, (f) absorption accelerators, as for example, quaternary ammonium compounds, (g) wetting agents, as for example, cetyl alcohol, and glycerol monostearate, magnesium stearate and the like (h) adsorbents, as for example, kaolin and bentonite, and (i) lubricants, as for example, talc, calcium stearate, magnesiUm stearate, solid polyethylene glycols, sodium lauryl sulfate, or mixtures thereof. In the case of capsules, tablets, and pills, the dosage forms may also comprise buffering agents. 162 WO 2005/030140 PCT/US2004/031523 [0253] Solid dosage forms as described above can be prepared with coatings and shells, such as enteic coatings and others well known in the art. They may contain pacifying agents, and can also be of such composition that they release the active compound or compounds in a certain part of the intestinal tract in a delayed manner. Examples of embedded compositions that can be used are polymeric substances and waxes. The active compounds can also be in microencapsulated form, if appropriate, with one or more of the above-mentiondd excipients. [0254] Liquid dosage form for oral administration include pharmaceutically acceptable emulsions, solutions, suspensions, syrups, and elixiMts. Such dosage forms are prepared, for example, by dissolving, dispersing, etc., a compound(s) of the invention, or a pharmaceutically acceptable salt thereof, and optional pharmaceutical adjuvants in a carrier, such as, for example, water, saline, aqueous dextrose, glycerol, ethanol and the like; solubilizing agents and emulsifiers, as for example, ethyl alcohol, isopropyl alcohol ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propyleneglycol, 1,3 butyleneglycol, dimethylformamide; oils, in particular, cottonseed oil, groundnut oil, corn germ oil, olive oil, castor oil and sesame oil, glycerol, tetrahydrofurfuryl alcohol, polyethyleneglycols and fatty acid esters of sorbitan; or mixtures of these substances, and the like, to thereby form a solution or suspension. [0255] Suspensions, in addition to the active compounds, may contain suspending agents, as for example, ethoxylated isostearyl alcohols, polyoxyethylene sorbitol and sorbitan esters, microcrystalline cellulose, aluminum metahydroxide, bentonite, agar-agar and tragacanth, or mixtures of these substances, and the like. [0256] Compositions for rectal administrations are, for example, suppositories that can be prepared by mixing the compounds, of the present invention with for example suitable non irritating excipients or carriers such as cocoa butter, polyethyleneglycol or a suppository wax, which are solid at ordinary temperatures but liquid at body temperature and therefore, melt while in a suitable body cavity and release the active component therein. [0257] Dosage forms for topical administration of a compound of this invention include ointments, powders, sprays, and inhalants. The active component is admixed under sterile conditions with a physiologically acceptable carrier and any preservatives, buffers, or propellants as may be required. Ophthalmic formulations, eye ointments, powders, and solutions are also contemplated as being within the scope of this invention. 163 WO 2005/030140 PCT/US2004/031523 [0258] Generally, depending on the intended mode of administration, the pharmaceutically acceptable compositions will contain about 1% to about 99% by weight of a compound(s) of the invention, or a pharmaceutically acceptable salt thereof, and 99% to 1% by weight of a suitable pharmaceutical excipient. In one example, the composition will be between about 5% and about 75% by weight of a compound(s) of the invention, or a pharmaceuticafly acceptable salt thereot with the rest being suitable pharmaceutical excipients. [0259] Actual methods of preparing such dosage forms are known, or will be apparentto those skilled in this art; for example, see Remington's Pharmaceutical Sciences, 18th Ed., (Mack Publishing Company, Easton, Pa., 1990). The composition to be administered will, in any event, contain a therapeutically effective amount of a compound of the invention, or a pharmaceutically acceptable salt thereof for treatment of a disease-state in accordance with the teachings of this invention. (02601 The compounds of the invention, or their pharmaceutically acceptable salts, are administered in a therapeutically effective amount which will vary depending upon a variety of factors including the activity of the specific compound employed, the metabolic stability and length of action of the compound, the age, body weight, general health, sex, diet, mode and time of administration, rate of excretion, drug combination, the severity of the particular disease-states, and the host undergoing therapy. The compounds of the present invention can be administered to a patient at dosage levels in the range of about 0.1 to about 1,000 mg per day. For a normal human adult having a body weight of about 70 kilograms, a dosage in the range of about 0.01 to about 100 mg per kilogram of body weight per day is an example. The specific dosage used, however, can vary. For example, the dosage can depend on a number of factors including the requirements of the patient, the severity of the condition being treated, and the pharmacological activity of the compound being used. The determination of optimum dosages for a particular patient is well known to one of ordinary skill in the art. Utility of compounds of the invention as screening agents [0261) To employ the compounds of the invention in a method of screening for candidate agents that bind to, for example c-Met, KDR, c-Kit, fIt-3, or fit-4, the protein is bound to a support, and a compound of the invention is added to the assay. Alternatively, the 164 WO 20051030140 PCT/US2004/031523 compound of the invention is bound to the support and the protein is added. Classes of candidate agents among which novel binding agents may be sought include specific antibodies, non-natural binding agents identified in screens of chemical libraries, peptide analogs, etc. Of particular interest are screening assays for candidate agents that have a low toxicity for human cells. A wide variety of assays may be used for this purpose, including labeled in vitro protein-protein binding assays, electrophoretic mobility shift assays, immunoassays for protein binding, functional assays (phosphorylation assays, etc.) and the like. [02621 The determination of the binding of the candidate agent to, for example, c-Met, KDR, c-Kit, fit-3, or flt-4 protein may be done in a number of ways. In one example, the candidate agent (the compound of the invention) is labeled, for example, with a fluorescent or radioactive moiety and binding determined directly. For example, thus may be done by attaching all or a portion of the c-Met, KDR, c-Kit, fit-3, or fit-4 protein to a solid support, adding a labeled agent (for example a compound of the invention in which at least one atom has been replaced by a detectable isotope), washing off excess reagent, and determining whether the amount of the label is that present on the solid support Various blocking and washing steps may be utilized as is known in the art. 10263] By "labeled" herein is meant that the compound is either directly or indirectly labeled with a label which provides a detectable signal, e.g., radioisotope, fluorescent tag, enzyme, antibodies, particles such as magnetic particles, chemiluminescent tag, or specific binding molecules, etc. Specific binding molecules include pairs, such as biotin and streptavidin, digoxin and antidigoxin etc. For the specific binding members, the complementary member would normally be labeled with a molecule which provides for detection, in accordance with known procedures, as outlined above. The label can directly or indirectly provide a detectable signal. [0264] In some embodiments, only one of the components is labeled. For example, c-Met, KDR, c-Kit, flt-3, or fit-4 protein may be labeled at tyrosine positions using '2I1, or with fluorophores. Alternatively, more than one component may be labeled with different labels; using 1I for the proteins, for example, and a fluorophor for the candidate agents. [0265] The compounds of the invention may also be used as competitors to screen for additional drug candidates. "Candidate bioactive agent" or "drug candidate" or grammatical equivalents as used herein describe any molecule, e.g., protein, oligopeptide, small organic molecule, polysaccharide, polynucleotide, etc., to be tested for bicactivity. 165 WO 2005/030140 PCT/IJS2004/031523 They may be capable of directly or indirectly altering the cellular proliferation phenotype or the expression of a cellular proliferation sequence, including both nucleic acid sequences and protein sequences. In other cases, alteration of cellular proliferation protein binding and/or activity is screened. In the case where protein binding or activity is screened, some embodiments exclude molecules aheady known to bind to that particular protein. Exemplary embodiments of assays described herein include candidate agents, which do not bind the target protein in its endogenous native state, termed herein as "exogenous" agents. In one example, exogenous agents further exclude antibodies to c Met, KDR, c-Kit, fit-3, or fit-4. [0266] Candidate agents can encompass numerous chemical classes, though typically they are organic molecules having a molecular weight of more than about 100 daltons and less than about 2,500 daltons. Candidate agents comprise functional groups necessary for structural interaction with proteins, particularly hydrogen bonding and lipophilic binding, and typically include at least an amine, carbonyl, hydroxyl, ether, or carboxyl group, for example at least two of the functional chemical groups. The candidate agents often comprise cyclical carbon or heterocyclyl structures and/or aromatic or polyaromatic structures substituted with one or more of the above functional groups. Candidate agents are also found among biomolecules including peptides, saccharides, fatty acids, steroids, purines, pyrimidines, derivatives, structural analogs, or combinations thereof. [0267] Candidate agents are obtained from a wide variety of sources including libraries of synthetic or natural compounds. For example, numerous means are available for random and directed synthesis of a wide variety of organic compounds and blomolecules, including expression of randomized oligonucleotides. Alternatively, libraries of natural compounds in the form of bacterial, fungal, plant and animal extracts are available or readily produced. Additionally, natural or synthetically produced libraries and compounds are readily modified through conventional chemical, physical and biochemical means. Known pharmacological agents may be subjected to directed or random chemical modifications, such as acylation, alkylation, esterification, acidification to produce structural analogs. [0268] In one example, the binding of the candidate agent is determined through the use of competitive binding assays. In this example, the competitor is a binding moiety known to bind to c-Met, KDR, c-Kit, flt-3, or flt-4, such as an antibody, peptide, binding partner, ligand, etc. Under certain circumstances, there may be competitive binding as between the 166 WO 2005/030140 PCT/US2004/031523 candidate agent and the binding moiety, with the binding moiety displacing the candidate agent [0269] In same embodiments, the candidate agent is labeled. Either the candidate agent, or the competitor, or both, is added first to for example c-Met, KDR, c-Kit, flt-3, or fit-4 for a time sufficient to allow binding, if present. Incubations may be performed at any temperature that facilitates optimal activity, typically between 4"C and 40 0 C [0270] Incubation periods are selected for optimum activity, but may also be optimized to facilitate rapid high throughput screening. Typically between 0.1 and 1 hour will be sufficient. Excess reagent is generally removed or washed away. The second component is then added, and the presence or absence of the labeled component is followed, to indicate binding. [0271J In one example, the competitor is added first, followed by the candidate agent. Displacement of the competitor is an indication the candidate agent is binding to c-Met, KDR, c-Kit, fit-3, or fit-4 and thus is capable of binding to, and potentially modulating, the activity of the c-Met, KDR, c-Kit, fit-3, or fit-4. In this embodiment, either component can be labeled. Thus, for example, if the competitor is labeled, the presence of label in the wash solution indicates displacement by the agent. Alternatively, if the candidate agent is labeled, the presence of the label on the support indicates displacement [0272] In an alternative embodiment, the candidate agent is added first, with incubation and washing, followed by the competitor. The absence of binding by the competitor may indicate the candidate agent is bound to c-Met, KDR, c-Kit, fit-3, or fIt-4 with a higher affinity. Thus, if the candidate agent is labeled, the presence of the label on the support, coupled with a lack of competitor binding, may indicate the candidate agent is capable of binding to c-Met, KDR, c-Kit, flt-3, or fit-4. [0273] It may be of value to identify the binding site of c-Met, KDR, c-Kit, flt-3, or fit-4. This can be done in a variety of ways. In one embodiment, once c-Met, KDR, c-Kit, flt-3, or fit-4 has been identified as binding to the candidate agent, the c-Met, KDR, c-Kit, flt-3, or fit-4 is fragmented or modified and the assays repeated to identify the necessary components for binding. [0274] Modulation is tested by screening for candidate agents capable of modulating the activity of c-Met, KJDR, c-Kit, fit-3, or fit-4 comprising the steps of combining a candidate agent with c-Met, KDR, c-Kit, fIt-3, or flt-4, as above, and determining an alteration in the 167 WO 2005/030140 PCT/US2004/031523 biological activity of the c-Met, KDR, c-Kit, fit-3, or fit-4. Thus, in this embodiment, the candidate agent should both bind to (although this may not be necessary), and alter its biological or biochemical activity as defined herein. The methods include both in vitro screening methods and in vivo screening of cells for alterations in cell viability, morphology, and the like. (0275] Alternatively, differential screening may be used to identify drug candidates that bind to native c-Met, KDR, c-Kit, fit-3, or fit-4, but cannot bind to modified c-Met, KDR, c-Kit, flt-3, or flt-4. [0276] Positive controls and negative controls may be used in the assays. For example, all control and test samples are performed in at least triplicate to obtain statistically significant results. Incubation of samples is for a time sufficient for the binding of the agent to the protein. Following incubation, samples are washed free of non-specifically bound material and the amount of bound, generally labeled agent determined. For example, where a radiolabel is employed, the samples may be counted in a scintillation counter to determine the amount of bound compound. [0277] A variety of other reagents may be included in the screening assays. These include reagents like salts, neutral proteins, e.g., albumin, detergents, etc which may be used to facilitate optimal protein-protein binding and/or reduce non-specific or background interactions. Also reagents that otherwise improve the efficiency of the assay, such as protease inhibitors, nuclease inhibitors, anti-microbial agents, etc., may be used. The mixture of components may be added in any order that provides for the requisite binding. Abbreviations and their Definitions [0278] The following abbreviations and terms have the indicated meanings throughout. Abbreviation Mning Ac acetyl ATP adenosine triphosphate BNB 4-bromomethyl-3-nitrobenzoic acid Boc t-butyloxy carbonyl 168 WO 2005/030140 PCT/US2004/031523 Abbreviation Meaning br broad Bi butyl "C degrees Celsius C- cyclo CBZ CarboBenZoxy = benzyloxycarbonyl d doublet dd doublet of doublet dt doublet of triplet DBU Diazabicyclo[5.4.O]undec-7-ere DCM dichloromethane = methylene chloride CH 2 C1 2 - DCB dichloroethylene DEAD diethyl azodicarboxylate DIC diisopropylcarbodiimide DEA N,N-diisopropylethyl amine DMAP 4-NN-dimethylaminopyridine DF N,N-diethylfonnamide DMSO dimethyl sulfoxide DVB 1,4-divinylbenzene EEDQ 2-ethoxy-l-ethoxycarbonyl-1,2-dihydroquinoline El Electron Impact ionization Et ethyl Fnoc 9-fluorenynethoxycarbonyl g gram(s) GC gas chromatography h or hr hour(s) HATU 0-(7-Azabenzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate ENDS hexametliyldisilazane HOAc acetic acid HO3t hydroxybenzotriazole HPLC high pressure liquid chromatography 169 WO 2005/030140 PCT/US2004/031523 Abbreviation Meaning L liters) M molar or molarity M multiplet me methyl mesyl methanesulfonyl Me MHJz megahertz (frequency) min minute(s) mL milliliter(s) mM millimolar mmol millinole(s) mol mole(s) MS mass spectral analysis MTE methyl t-butyl ether N normal or normality NBS N-bromosuccinimide NCS N-chlorosuccinimide nIM .nanomolar NMO N-methyhnorpholine oxide NMR nuclear magnetic resonance spectroscopy PEG polyethylene glycol pBY poly-glutamine, tyrosine Ph phenyl PhOH phenol PfP pentafluorophenol PfPy pentafluoropyridine PPTS Pyridinium p-toluenesulfonate Py pyridine PyBroP bromo-tris-pyrrolidino-phosphonium hexafluorophosphate q quartet 170 WO 2005/030140 PCT/US2004/031523 Abbreviation Meaning RT Room temperature Sat'd saturated a singlet s- secondary tertiary t or tr triplet TBDMS t-butyldimethylsilyl TES triethylsilane TFA tiuoroaceic acid TM tetrahydrofmran TMOF tdimethyl orthofonnate TfMS tdimethylsilyl tosyl p-toluenleslfoy Trt tdiphenylmethyl uL .

microliter(s) UM Mcromole(s) or micromolar Synthesis of Compounds [0279] Schemes 1 and 2 depict general synthetic routes for compounds of the invention and are not intended to be limiting. More specifically, Scheme 1 depicts synthesis of quinazoline compounds, and Scheme .2 depicts synthesis of quinoline compounds. Specific examples are described subsequently to these general synthetic descriptions so as to allow one skilled in the art to make and use either quinazolines or quinolines of the invention. Scheme 1 171 WO 2005/030140 PCT/US204/031523 P CC2R P s0 2 R EP) ENH 2 1 2 3 zAr L 0I P0 P -P * N NH EPO NH 6 5 4 Ar Ar ZO Z 7 8 [0280] Referring to Scheme 1, a benzoic ester 1, where R is typically but not necessarily a methyl radical and P is typically but not necessarily an alkyl group, is O-alkylated at the oxygen para to the carboxylate group with an electrophile to afford a substituted derivative 2. P is typically a lower alkyl group, but may be a protecting group that is removed later in a synthesis. When P is a lower alkyl group it may possess functionality initially, or be derivitized to contain such fimctionality at various stages of the synthesis. The group, El, may represent either a protecting group, e.g. benzyl, or a group that either has moieties present in compounds of the invention or possesses functionality that serve as a precursors to such groups. Aromatic ring nitration and reduction of the corresponding nitro group are carried out in a regio- and chemoselective manner by methods well known in the art to give anthranflate derivative 3. Formation of quinazolin-4-one 4 is canied out by methods well known in the art, for example by heating 3 in formamide solution in the presence of ammonium formate or for example by heating directly with formamidine hydrochloride. Introduction of 4-position functionality groups is carried out by methods known in the art. For example, quinazolin-4-one 4 is converted to an intermediate quinazoline 5, where "L" represents a leaving group, e.g. chlorine. Quinazoline 5 is then converted to 6 by reaction with a range of nucleophiles, e.g. amines, alcohols, and thiols. After formation of 6, group "Z" is either left "as is" or converted at some subsequent stage to a derivative thereof. For example when Z is -NH-, then the hydrogen on the nitrogen 172 WO 2005/030140 PCT/US2004/031523 may optionally be replaced with an alkyl group, or when Z is sulfur, then that sulfur atom may be oxidized to, for example, a sulfone. Structure 6 may represent compounds of the invention or, for example when El serves as a protecting group, Bl may be removed to provide phenol 7. Introduction of a group e is carried out by methods well established in the art; for example alkylation with an appropriately derivatized alkyl halide (or mesylate or the like) to give 8 which also represents compounds of the invention. Scheme 2 RI COCH RIO COCH 3 RIO COAC H 3 POa NO P NH 9 10 11 O " Ar OH R O0 RN)) O. R Oc t 14 13 12 T Ar - 0 EO 15 [0281] Scheme 2 shows a general route used to make exemplary quinolines of the invention. For example, compound 9 contains an alkyl group, R, a protecting group, P. The arrangement of the protected and alkylated phenolic oxygens may vary from the pattern depicted in compound 9. Compound 9 is nitrated to provide compound 10. The nitro group of compound 10 is reduced to give aniline 11. Compound 11 is treated, for example, with ethyl formate under basic conditions followed by acidification and isolation to form 4-hydroxy quinoline 12, Quinoline 12 may be converted to compounds of the invention in a number of ways. For example, the 4-oxygen is used as a nucleophile in a nucleophilic aromatic substitution reaction to fbrm quinoline-aryl-ether 13. In another example, compound 13 is further derivatized, via removal of protecting group P, to afford compound 14. The 7-hydroxy of compound 14 is alkylated, for example with electrophile B, to provide a compound of the invention. As discussed in relation to Scheme 1, 173 WO 2005/030140 PCT/US2004/031523 variations on any of the above steps are possible, and intermediates in these schemes, for example compounds 12, 13, and 14 way also be compounds of the invention according to formula 1. Also, for example, the 4-hydroxy quinoline compound 12 are converted to a corresponding 4-nitrogen or 4-sulfur quinoline using chemistry known in the art to make compounds of the invention, or alternatively the corresponding 4-nitrogen or 4-sulfur quinolines are made via routes analogous to that depicted in- Schemes I and 2. [0282] Schemes I and 2 are illustrative of quinolines and quinazolines having oxygen substitution at their respective 6- and 7-positions; the invention is not so limited, but rather is intended to encompass quinolines and quinazolines not necessarily having substitution, oxygen or otherwise, at their respective 6- or 7-positions. [0283] Schemes 3 and 4 depict generalized synthetic routes to show the process of the invention to make compounds of formua XXI and is not intended to be limiting. Mom specifically, Schemes 3 and 4 depict convergent syntheses of quinoline and quinazoline compounds as described herein. Specific examples are described subsequently to this general synthetic description so as to allow one of ordinary skill in the art to practice the invention. [0284) Referring to Scheme 3, a benzoic ester 16 for example, where R is typically but not necessarily a methyl radical and R1 is typically but not necessarily one or more alkoxy or hydroxy groups. In a typical synthesis, at least one of R1 within Scheme 3 is a hydroxyl which is converted (or protected )via one or more steps to a group important to the activity of the compounds as described as kinase modulators (in the case that -OH itself is desired in the final compound, then deprotection affords the -OH, vide supra). Preferably, but not necessarily, this group is complete once the synthesis of XXH is complete. By building desired complexity into XXI prior to combination with XXHI, convergent syntheses' advantages over serial syntheses are realized more fully. Regloselective aromatic ring nitration, and reduction of the corresponding nitro group, are carried out in a regio- and chemoselective manner by methods well known in the art to give anthranilate derivative 17. Formation of quinazoline or quinoline 4-one 18 is carried out by methods well known in the art. For example by heating 17 in formamide solution in the presence of ammonium formate, or by heating 17 with formam'idine hydrochloride, the quinazoline-4-one analog is made. In another example 17 is treated, for example, with ethyl formate under basic conditions followed by acidification and isolation to form the 4-hydroxy quinoline analog (a tautomer of the 4-one). In this scheme P represents either carbon or nitrogen atom with 174 WO 2005/030140 PCT/US2004/031523 the appropriate number of hydrogen to fill their respective normal valence bonding schemes; J' is a precursor to J. Radicals J and R" are in accord with formula XXI. Introduction of 4-position functionality is carried out by methods known in the art. For example, 4-one 18 is converted to XXII, where "P" represents a suitable leaving group (in accord with formula XXI), e.g. chlorine (via dehydration/chlorination of 18 to give XXII). In another example, a 4-hydroxy analog is converted to a sulfonyl ester, e.g. the trifluoromethane sulfonate. Scheme 3 C0 2 R riz R (R1).

4 4

NH

2 '>- NAF 16 17 18

P

1 ( or - -R, 0~ (R) 0 4 N

R

70 XXII [0285] Scheme 4 shows a general route used to make compounds of formula XXII. For example, aromatic compound 19, where "X" is a leaving group, such as fluorine and "'E" is an electron withdrawing group such as nitro, is converted to 20 by reaction with a range of nucleophiles, e.g. amines, alcohols, and thiols (where '" is oxygen, nitrogen (substituted or not), or sulfur). In this case, "R" represents a removable group, for example benzyl. In a typical synthesis, after formation of 20, group "F' is either left "as is" or converted at some subsequent stage to a derivative thereof. In the example depicted, E is converted to B', a precursor to B in accord with fonnula XX, to make 21. For example if B is a nitro, then B' could might be an amino group, made via reduction of the nitro group. Structure 21 may be further derivitized by synthesis of -B-L-T in accord with formula XXI. In scheme 4, this is depicted as a serial process whereby L', a precursor to L, is introduced to give 22, followed by introduction of T' (a precursor to T) to give 23. In some cases, -L-T is preformed and appended to B. One of ordinary skill in the art would appreciate that variations on any of the above steps are possible. Compound 23 is converted to XXII via conversion of T' to T and introduction of P 2 (for example, when R is benzyl, removal of the benzyl after completion of -B-LT). 175 WO 2005/030140 PCT/US2004/03152 3 Scheme 4 Ar-E f

-

-B' x z RRA.z

(R

2 )o.-4(R _ ( 0 4 19 20 21 -B- Ar-B-L-T

.

-B T (R2)0_4 (iR2 04 (R ?)0.4 22 23 [0286] As discussed above, one aspect of the invention encompasses combination of XXII and XXIII to make compounds of formula XXI. Because of the diversity and complexity of compounds described for kinase modulation (vide supra), methods of the invention provide advantages to serial synthesis. Ar - B T (RI)o.

4

-

R70 XXI Examples [0287] The following examples serve to more fully describe the manner of using the above-described invention, as well as to set forth the best modes contemplated for carrying out various aspects of the invention. It is understood that these examples in no way serve to limit the true scope of this invention, but rather are presented for illustrative purposes. All references cited herein are incorporated by reference in their entirety. Generally, but not necessarily, each example set out below describes a multi-step synthesis as outlined above. 176 WO 2005/030140 PCT/US2004/031523 Quinoline and Quinazoline Syntheses Example 1 0 H2S04 HNO N 0C [0288] Synthesis of 1-(4-Benzyloxy-5-methoxv-2-nitro-phenyl)-othanone. 1-(4 Benzyloxy-3-methoxy-phenyl)-ethanone (200 mmoL 51.3 g) dissolved in DCM (750ml) and the mixture cooled to 0* C. Nitric acid (90%, 300 mmol, 14 ml) was added dropwise to the cooled solution over 20 minutes. Sulfuric acid (96.2%, 300 mmol, 8.75 ml) was then added dropwise over 40 minutes at 0"C. [0289] Additional nitric acid (200 mmol, 9.4 ml) was added dropwise over 20 minutes. The reaction mixture was diluted with water (300 ml) and wash with water (3 X 200 nil), Sat. NaHCQ3 (4 X 200 ml, or until neutral). The organic layer was dried over Na2SO4 and concentrated. [0290] The cmude mixture was recrystallized with DMF to give 22.5 g of the nitro product. The IDMF layer was concentrated and recrystallized with ethyl acetate to give additional 8.75g of the product. The ethyl acetate layer was concentrated and purified on silica column using 20% EtOAc/hexanes to gave another 4.75 g of the product. Total yield is 36 g, (-60%). IH NMR (CDC13): 7.647 (1H, s), 7.446-7.333 (5H, m), 6.745 (1H, s), 5.210 (2H, s), 3.968 (3, s), 2.487 (3H, s). Example 2 FeN1Fe 'N-C 1 NH 2 0 N NH OAc 6- A [0291] Synthesis of 1-(2-Amino-4-benzyloxy-5-methoxy-phenyl)-ethanone. A Mixture of iron powder (477 mmnol, 27 g), ammonium acetate (500 mmol, 31.g), 1-(4-Benzyloxy-5 methoxy.2-nltro-phenyl)-ethanone (120 mmol, 36 g), toluene (500 ml) and water (500 ml) was refluxed overnight, or until completion. The mixture was filtered through celite and 177 WO 20051030140 PCT/US2004/031523 washed with EtOAc. The organic layer was washed with water and Sat NaCl, dried over Na2SO4, and concentrated to afford the product, 90%. IH NMR (CDC3): 7.408-7.298 (5H1, m), 7.130 (1H, s), 6.155 (2H, br), 6.104 (1H, s), 5.134 (21H, s), 3.834 (3, s), 2.507 (3H, s). LC/MS (M+1= 272). Example 3 + NH MeoNa 0II H DME N 0 N [0292] Synthesis of 7-Benzyloxv-6-methoxy-quinolin-4-o1. To a solution of 1-(2-Amino 4-benzyloxy-5-methoxy-phenyl)-ethanone (108 mmol, 29.3 g) in DME (700 ml) was added sodium methoxide (432 mmol, 23.35 g). The mixture was stirred for 30 minutes. Ethyl formate (540 mmol, 44 ml) was added and the mixture was stirred overnight. (Additional sodium methoxide may be needed if reaction is not complete as monitored by LC/MS.) After the reaction was completion, the mixture was diluted with water (40 ml) and acidified to neutral with 1M 1C. The precipitate was filtered and washed with water, dried in vacuo to afford 22g (72%) of 7-benzyloxy-6-methoxy-quinolin-4-.ol. 1H NMR (CDC]3): 10.7 (1H, br), 7.703 (1H, s), 7.493-7.461 (1H, t), 7.431-7.413 (2H, br d), 7.372 7.333 (2H, t), 7.296-7.283 (1H, d), 6.839 (1H, s), 6.212-6.193 (111, d), 5.212 (2H, s), 3.965 (3, s). LC/MS (M+1 = 282). Example 4

NO

2 o 0 2 N F FF ___ N [0293] 7-Benzyloxy4-(2-fluoro-4-nitro-ph noxy)6-methoxy- qinoline. To a round bottom flask equipped with a magnetic stir bar was added 7-Benzyloxy-6-methoxy-1H quinolin-4-one (12.2 g, 43.3 mmol, 1.0 eq.), acetonitrile (150ml), DMF (150ml) and 178 WO 2005/030140 PCT/US2004/031523 cesium carbonate (28.2 g, 86.5 mmol, 2.0 eq). The mixture was strred at room temperature for 30 minutes at which time 1,2-difluoro4-nitro-benzene (7.57 g, 47.6 mmol, 1.1 eq) was added over a 10 minute period. After 2 hours the reaction was complete at which time 75% of the MeCN and DMF was removed and the resulting solution was poured over into ice water. The solid was filtered and dried and further columned with a biotage system. The eluent was 1:3 ethyl acetate/hexane. Removal of the solvent afforded 7-Benzyloxy-4-(2-fluoro-4-nitro-phenoxy)-6-methoxy-quinoline as a pale green solid (7.4 g, 41% yield). lH NMR (400 MHz, CDCI 3 ): 8.53 (d, 1H), 8.42 (dd, 1Hl), 8.16 (m, 11), 7.5 (m, 8H), 6.76 (d, 1H), 5.31 (s, 2$, 3.92 (s, 3H); MS (E) for C27FN205: 421 (MH). Example 5

NO

2

NO

2 0 N I HO N [0294] 42-Fluoro-4-nitro-phenoxy)-6-methoxy-guinolin-7-oL To a round bottom flask equipped with a magnetic stir bar was added 7-benzyloxy-4-(2-fluoro-4-nitro-phenoxy)- 6 imethoxy-quinoline (2.9 g, 6.9 mmol, 1.Oeq) and 33% HBr in acetic acid (30 ml). The mixture was stirred at wrom temperature for 3 hours and diluted with ether to give a pale white solid. The solid was filtered, washed with ether and dried to yield 4-(2-Fluoro-4 nitro-phenoxy)-6-methoxy-quinolin-7-ol as a pale white solid (2.74 g, 97.5% yield). 1H NMR (400 MHz, CDCl 3 ):'11.89 (bs, 11), 8.87 (d, 1R), 8.57 (d, 1H), 8.30 (d, 1$, 7.89 (m, 1H), 7.73 (a, 111), 7.55 (s, 1M), 4.03 (a, 3M); MS (ELI) for C 16 Hu 1

FN

2 0 5 : 421 (M+Hf). Example 6

NOO

2 )0 N2 O F CbzC N 179 WO 2005/030140 PCT/US2004/031523 [0295 5-44-(2-Fluoro4-nitro-phenoxy6-mthox-uino ln-7-y1oxmethy-hexahydo cyclopenta[clpyrrole-2-carboxylic acid benzyl ester. To a round bottom flask equipped with a magnetic stir bar was added 4-(2-Fluoro-4-nitro-phenoxy)-6-methoxy-quinolin-7-ol (2.74 g, 6.7 mmol, 1.0 eq.), DMA (30ml) and cesium carbonate (6.6 g, 20.2 mmol, 5.Q eq). The mixture was stirred at room temperature for 30 minutes at which time 5 methanesulfonyloxymethyl-hexahydro-cyclopenta[c]pyrrole-2-carboxylic acid benzyl ester (2.6 g, 7.3 mmol, 1.1 eq) was added. The reaction was heated to 750 C and allowed to stir overnight. After allowing the reaction to cool to room temperature the reaction was poured into water. The solid was filtered and was then dissolved in EtOAc and washed 2X water, 1X brine and dried over NaSO 4 . The solvent was removed to yield 5-[4-(2 Fluoro-4-nitro-phenoxy)-6-methoxy-quinolin-7-yloxymethyl}-hexahydro cyclopentafc]pyrrole-2-carboxylic acid benzyl ester as a cream solid (3.7 g, 94% yield). 'H NMR (400 Mfz, CDC1 3 ): 8.55 (d, 1), 8.15 (d, 1H), 8.09 (d, 1H), 7.32 (m, 8H), 6.52 (d, 1H), 5.11 (d, 211), 4.13 (d, 2H), 3.95 (s, 3H), 3.57 (m, 2H), 3.43 (m, 2H), 2.93 (m, 3H), 2.16 (m, 2R), 1.39 (m, 2W); MS (BI) for C3nH30FN307: 588 (M++. Example 7 M0N 2 -~N0 2 0zNN0 N ObzN_; -1N [0296] 4-(2-Fluoro-4-nitro-phenoxy)-6-methoxy-7-(octahydro-cyclopentafclpyrrol-5 ylmethoxy)-guinoline. To a round bottom flask equipped with a magnetic stir bar was added 5-[4-(2-Fluoro-4-nitro-phenoxy)-6-methoxy-quinolin-7-yloxymethyl] hexahydrocyclopenta-[c]pyrrole-2-carboxylic acid benzyl ester (2.5 g, 4.1 mmol, 1.aeq), 33% HBr in acetic acid (5 ml) and acetic acid (5 ml). The mixture was stirred at room temperature for 1 hour and diluted with EtOAc to give a pale orange solid. The solid was filtered, washed with EtOAc and dried, giving 4-(2-Fluoro-4-nitro-phenoxy)-6-methoxy-7 (octahydro-cyclopenta[c]pyrrol-5-ylmethoxy)-quinoline (2.1 g, 95% yield). 'H NMR (400 MHz, CDCb): 8.83 (d, 1H), 8.32 (m, 2H), 8.02 (s, 1H), 7.76 (t, 1$), 7.65 (s, 11), 6.89 (d, 180 WO 2005/030140 PCT/US2004/031523 111), 5.3 (d, 211), 4.11 (m, 31), 3.26 (m, 4H), 2.95 (m, 2R), 2.68 (m, 3H), 2.36 (m, 2H), 1.68 (M 2H); MS (BI) for C 2 4H4PNsO 3 : 454 (M+Ht). Example 8

NO

2

NO

2 0N.0F F HN O N .....-N [0297] 4-(2-luoro-4-nitro-phenoxy)-6-methoxy-7-(2-methyl-octahydro cyclopentafclpynol-5-ylmethoxy)-quinoline. To a round bottom flask equipped with a magnetic stir bar was added 4-(2-Fluoro-4-nitro-phenoxy)-6-methoxy-7-(octahydro cyclopenta[c]pyrrol-5-ylmethoxy)-quinoline (2.1 g, 3.9 mmol, 1.0 eq.) and acetonitrile/water 1:1 (5ml, 5ml). The reaction mixture was then cooled to 00 C and 37% solution of formaldehyde in water was added (0.2 g, 7.8 mmol, 2.0 eg). While keeping the temperature at 0 0 C Na(OAc)sBH was added (4.4g, 20.7 mmol, 3.0 eq). After 1 hour the pH was adjusted to 10 and the aqueous was extracted 2 x DCM (100 ml). Removal of the DCM resulted in a white solid. The compound was further purified with a biotage systern using an eluent EtOAc and 5% MeOH, affording 4-(2-luoro-4-nitro-phenoxy)-6 methoxy-7-(2-methyl-octahydrocyclopeuta-[c]pyrrol-5-ylnethoxy)-quinoline (0.9 g, 50% yield). ). 'H NMR (400 MHz, CDC13): 8.57 (d, 11), 8.14 (dd, 1H), 8.12 (dd, 1H), 7.41 (s, 2H), 7.34 (t, 1H), 6.54 (d, 111), 4.19 (d, 2H), 4.01 (s, 3H), 2.61 (m, 4H), 2.43 (m, IH), 2.33 (s, 3H), 2.11 (m, 411), 1.32 (m, 2H); MS (El) for C2sH2 6 FNOs: 468 (M+H. Example 9

AONO

2 N NH 2 N 18 'N' NrN ANN 181 WO 2005/030140 PCT/US2004/031523 [0298] 3-Fluoro-4-6-methoxy-7-(2-methyl-octahydro-cyclopentarcpyrrol-5-ylmethox) quinolin-4-yloxyl-phenvlamine. To a par hydrogenation reaction vessel was added 4-(2 fluoro-4-nitro-phenoxy)-6-methoxy-7-(2-methyl-octahydro-cyclopenta[c]pyrrol-5 ylmethoxy)-quinoline (0.800 g, 1.6 mmol, 1.0 eq.), DMF (50 ml), EtoAc (50mI), MeOH (50ml), TEA (5ml) and 10% Pd/C (200 mg). The vessel was placed on the par hydrogenator at 35 psi overnight. The Pd was filtered and the solvent removed to give 3 fluoro-4-[6-methoxy-7-(2-methyl-octahydro-cyclopenta[c]pyrrol-5-ylmethoxy)-quinolin 4-yloxy]-phenylamine as an off yellow solid (0.78 g, 99% yield). 'H NMR (400 MHz, CDCls): 8.45 (d, 1H), 7.57 (s, 111), 7.36 (s, 111), 7.05 (t, 111), 6.54 (m, 2H), 6.39 (d, Ip, 4.16 (d, 2H), 4.01 (s, 3H), 3.81 (m, 311), 2.61 (m, 311), 2.41 (m, 1H), 2.29 (s, 3H), 2.23 (m, 2H), 1.32 (m, 2H); MS (BI) for C2 5

H

2 8FN 3 0 3 : 438 (M+H). Example 10 O NH 2 CN .- II A F -J- .- F O F NN [0299] 1-{ 3-Fluoro-4-f6-methoxy-7-(2-methyl-octahydro-cyclopentaflpcrrol-5 yLmethoxv)-quinolin-4-yloxv]-phenyl}-3-phenvlacetl-thiourea. To a round bottom flask equipped with a magnetic stir bar was added 3-fluoro-4-[6-methoxy-7-(2-methyl octahydro-cyclopenta[cjpyrrol-5-ylmethoxy)-quinolin-4-yloxy]-phenylamine (0.78 mg, 1.7 mmol, 1.0 eq.), toluene (10ml), ethanol (10ml) and phenyl-acetyl isothiocyanate (1.64 g, 9.2 mmol, 4.5 eq). The reaction mixture was stirred at room temperature overnight. After removal of the solvent the product was purified with a biotage system using an eluent EtOAc and 4% TEA (2L) then EtOAc, 4% TEA, 1% MeOH (1L). The solvent was removed to give 1-{3-fluoro-4-[6-methoxy-7-(2-methyl-octahydro-cyclopenta[c]pyrrol-5 ylmethoxy)-quinolin-4-yloxyl-phenyl}-3-phenylacetyl-thiourea (0.5 g, 50% yield). 'H NMR (400 MHz, DMSO): 8.48 (d, 1H), 7.92 (dd, 111), 7.53 (s, 1H), 7,40 (m, 4H), 7.33 (d, 2M), 7.23 (m, 2H), 6.54 (d, 2H), 6.39 (d, 111), 4.21 (d, 21), 4.02 (s, 3H), 3.81 (m, 3H), 182 WO 2005/030140 PCTIUS2004/031523 2.87 (d, 2H), 2.73 (m, 4H), 2.53 (i, 1H), 2.27 (m, 2H), 2.01 (s, 3H), 1.36 (m, 21); MS (EI) for C3 4

I

35

FN

4 0 4 S: 615 (M+H*). Example 11 F NH 2 N F NH 4 SCN, Br 2 a s NH2 [0300] 6-(6,7-Dimethoxyauinolin-4-vloxv)-5-fluoro-benzothiazol-2-ylamine. 4-(6,7 dcimethoxy-quinolin-4-yloxy)-3-fluoro-phenylamine (1.00g, 3.18mmol) was dissolved in AcOH (8.Oml), to which was added NHL 4 SCN (486mg, 6.38mmol) and the mixture cooled in an ice bath. Br 2 (0.33ml, 6.42mmol) in AcOH (0.33ml) was added dropwise with stirring. After addition was complete, the reaction mixture was stirred at room temperature. After one hour, more NH4SCN (1.0g, 13.1mmol) was added, followed by more Br 2 (0.33ml, 6.42mmol) in AcOH (0.33ml), dropwise with stiring. The reaction mixture was then heated to reflux for several minutes. Upon cooling to room temperature, solids were filtered and washed with AcOH, followed by H20. The volume of the filtrate was reduced in vacuo and the pH adjusted to pH 9-10 with 1.ON NaOK The resulting solids were filtered, washed with H20, and dried under high vacuum to give 6-(6,7 dimethoxy-quinolin-4-yloxy)-5-fluoro-benzothiazol-2-ylamine (568mg, 48%). 'H-NMR (400MHz, DMSO): 8.45 (d, 1M), 7.82 (d, 1H), 7.73 (br s, 211), 7.53 (s, 111), 7.38 (m, 2H), 6.44 (d, 11), 3.94 (s, 6H). LC/MS Calcd for [M+H]* 372.1, found 372.2 Example 12 ZO NH IIZII~C~~NH2 N -0):) NEtN y1 Q ' N [0301] N-f6-(6,7-Dimethoxv-quinolin-4-yloxy)-5-fluoro-benzothiazol-2-yjl2-phenyl acetamide. 6-(6,7-dimethoxy-quinolin-4-yloxy)-5-fluoro-benzothiazol-2-ylamine (95mg, 183 WO 2005/030140 PCT/US2004/031523 0.25mmol), Et 3 N (0.10ml, 0.72mmol), phenylacetyl chloride (0.044ml, 0.33mmol), and THW (l.0m1) were combined and stirred at room temperature for 1 hr. Additional phenylacetyl chloride (0.044ml, 0.33mmol) was added and the mixture heated to reflux for 1-2 hrs. After cooling to room temperature, the reaction mixture was diluted with 1:1 AcCN:H 2 0 (1.0ml) and the resulting solids filtered, washed with 1:1 AcCN:Hi 2 O and dried under high vacuum to give N-[6-(6,7-dimethoxy-quinolin-4-ylaxy)-5-fluoro-benzothiazol 2-yl]-2-phenyl-acetamide (72mgs, 59%). 'H-NMR (400MHz, DMSO): 12.80 (s, 1H), 8.54 (d, 1H), 8.18 (d, 1H), 7.91 (d, 11), 7.60 (s, IH), 7.45 (s, 1H), 7.34 (mn, 4M), 7.28 (im, 111), 6.60 (d, 1H), 3.98 (s, 311), 3.06 (s, 311), 3.86 (s, 2H). LC/MS Calcd for [M+H]* 490.1, found 490.0. Example 13 CI FX

NH

2 N aN N C6N N CBZ CBZ [0302] 5-[4-(4-Amino-2-fluor-phenoxy)-6-methoxy-quinazolin-7-yloxymethylJ hexahydro-cyclopenta[epyrole-2-carboxylic acid benzyl ester. 4-Amino-2-fluoro-phenol (1.53g, 12.Ommol) was dissolved in dry DMF (30ml) to which was added 60% NaH (774mg, 19.3mmol). After the mixture was stirred at room temperature for several minutes, a suspension of 5-(4-chloro-6-methoxy-quinazolin-7-yloxymethyl)-hexahydro cyclopenta[cjpyrrole-2-carboxylic acid benzyl ester (4.70g, 6.7mmol) in dry DMF (40il) was added. The reaction mixture was stirred at room temperature for 1-2 hrs, then diluted with EtOAc and washed with sat'd NaHCO 3 (3x), LO (lx), sat'd NaCI (1x), dried (Na 2 SO4), and concentrated in vacuo to give crude 5-[4-(4-amino-2-fluoro-phenoxy)-6 methoxy-qulnazolin-7-yloxymethyl]-hexahydro-cyclopenta[clpyrrole-2-carboxylic acid benzyl ester (5.6g, -100%) which was used in the next reaction without further purification. 'H-NMR (400MHz, DMSO): 8.50 (s, 1H), 7.48 (s, 1H), 7.34 (m, 5H), 7.28 (m, 1H), 7.02 (t, 1H), 6.48 (dd, 1M), 6.40 (dd, 111), 5.40 (br a, 2H), 5.05 (s, 2H), 4.16 (d, 2H), 3.92 (s, 3H), 3.48 (m, 2H), 3.30 (mn, 2H), 2.65 (m, 2H), 2.52 (m, UT), 2.10 (m, 2H), 1.30 (m, 2H), LC/MS Caled for [M+H] 559.2, found 559.4. 184 WO 2005/030140 PCT/US2004/031523 Example 14 01 H H AgSCN N N P H2N F N OgSGN 0~~ C2N N* CB CBt GB [0303] 5-{4-2-Fluoro-4-3-phenylacetl-thioureido)-phenoxy-6-methoxv-unazolin-7 yloxymethyll-hexahydro-cyclopentafclpyrrole-2-carboxylic acid benzyl ester. Phenylacetyl chloride (2.65ml, 20.0mmol) and AgSCN (4.92g, 29.6mmol) were combined in dry toluene (50ml) and heated to reflux for 2 hrs. The reaction mixture was allowed to cool to room temperature, the solids were filtered through celite and the filtrate concentrated in vacuo. The resulting oil was combined with 5-[4-(4-amino-2-fluoro phenoxy)-6-methoxy-quinazolin-7-yoxymethyl]-hexahydro-cyclopenta[c]pyrrole-2 carboxylic acid benzyl ester (5.6g, 10mmol) in 1:1 EtOH:toluene (100ml) and the mixture stirred at room temperature for 1-2 hts. The reaction mixture was diluted with EtOAc and washed with sat'd -NaHCO 3 (3x), H2O (1x), sat'd NaCl (1x), dried (Na 2

SO

4 ), and concentrated in vacuo. The resulting oil was purified by flash chromatography (3:1 EtOAc:hexanes) to give 5-{4-[2-fluoro-4-(3-phenylacetyl-thioureido)-phenoxy]- 6 methoxy-quinazolin-7-yloxymetbyl}-hexahydrocyclopenta[cpyrrole-2-carboxylic acid benzyl ester (3.61g, 49%) as a dark brown foam. 'H-NMR (400MEfz, DMSO): 12.44 (s, IH), 11.80 (s, 1H), 8.54 (s, 1H, 7.90 (m, 111), 7.53 (s, 1H), 7.48 (m, 2H), 7.38 (s, i), 7.34 (m, 7H), 7.28 (M, 3H), 5.05 (s, 2H), 4.16 (d, 2H), 3.94 (s, 3H), 3.72 (s, 2W, 3.48 (m, 2H), 3.30 (m, 2H), 2.65 (in, 2H), 2.52 (m, 1H), 2.10 (m, 211), 1.30 (m, 2H). LC/MS Calcd for [M+H* 736.2, found 736.0. Example 15 H H HF rr N F .N N,, (F _ _ N 33% HBR/ AcOH H B N 15HN 2Hr 185 WO 2005/030140 PCT/US2004/031523 [0304] 1-{ 3 -Fluoro-4-[6-methoxy-7-(octahydro-cyclopenta[c]pyrrol-5-ylmethoxy) quinazolin4-yloxy]-phenyl}-3-phenylacetyl-thiourea, dihydrobromide salt. 5-{4-[2 Fluoro- 4 -(3-phenylacetyl-thioureido)-phenoxy]-6-methoxy-quinazolin-7-yloxymethyl} hexahydro-cyclopenta[c]pyrrole-2-carboxylic acid benzyl ester (3.3g, 4.5mmol) was dissolved in AcOH (70ml) to which was added 33%HBr in AcOH (12ml). The reaction mixture was stirred at room temperature for 1 hr, diluted with Et 2 0 (1000ml) and the resulting solids filtered, washed with Et 2 O, and dried under high vacuum to give the 1-{3 fluoro-4-[6-methoxy-7-(octahydro-cyclopenta[c]pyrrol-5-yhnethoxy)-quinazolin-4 yloxy]-phenyl}-3-phenylacetyl-thiourea, dihydrobromide salt (3.4g, 100%). 1 H-NMR (400MHz, DMSO): 12.42 (s, 1H), 11.80 (s, 1H), 8.84 (br s, 211), 8.64 (s, 1H), 7.92 (M, 11), 7.59 (s, 1H), 7.49 (m, 211), 7.41 (s, 1H1), 7.33 (m, 4H), 7.27 (m, 1H), 4.17 (d, 2H), 3.95 (s, 3H), 3.73 (s, 2H), 3.17 (m, 2H), 3.10 (m, 2H), 2.83 (m, 2H), 2.45 (m, 1H), 2.15 (, 211), 1.30 (m, 211). LC/MS Calkd for [M+H]* 602.2, found 602.1. Example 16 H No; Y F -Formaldehyde N Na(OAo) 3 8HN HN 2HBr [0305] 1-{3-Fluoro-4-[6-methoxy-7-(2-methyl-octahydro-cyclopenta[c]pyrrol-5 ylmethoxy)-quinazolin-4-yloxy]-phenyl}-3-phenylacetyl-thiourea. 1-{3-Fluoro-4-[6 methoxy-7-(octahydro-cyclopenta[c]pyrrol-5-ylmethoxy)-quinazolin-4-yloxy]-phenyl}-3 phenylacetyl-thiourea, dihydrobromide salt (3.4g, 4.5mmol) was dissolved in in a combination of AcCN (100ml), H2O (30ml), and AcOH (2.45m). Formaldehyde (37% in H20, 855mI, 10.5mmol) was added and the mixture cooled in an ice bath. Na(OAC) 3 BH (2.99g, 14.1mmol) was added and the reaction mixture was stirred at 0 C for 1 hr, followed by stirring at room temperature for 2 hrs. The reaction mixture was neutralized with the addition of sat'd NaHCO 3 and then congentrated in vacuo. The resulting aqueous mixture was extracted with CH 2 C1 2 (3x). The combined extractions were washed with sat'd NaHCO 3 (lx), sat'd NaCl (1x), dried (Na 2 SO4), and concentrated in vacuo. The 186 WO 2005/030140 PCT/US2004/031523 resulting residue was purified by flash chromatography (100% EtOAc, followed by 4% Et 3 N in EtOAc) to give the free base of 1-{3-fluoro-4-[6-methoxy-7-(2-methyl-octahydro cyclopenta[cjpyrrol-5-ylmethoxy)-quinazolin-4-yloxy]-pheny}-3-phenylacetyl-thiourea (1.13g, 40%). The free base was converted to the HCl salt by dissolving the free base in a mixture of 1:1 AcCN:H 2 0 containing 2-3 equivalents of 1 N HC and lyophilizing to give the HC1 salt of 1-{3-fluoro-4-[6-methoxy-7-(2-methyl-octahydro-cyclopenta[c]pyrrol-5 ylmethoxy)-quinazolin-4-yloxy-phenyl}-3-phenylacetyl-thiourea as a white solid. IH NMR (400MHz, DMSO): 12.44 (s, 1H), 11.83 (s, 111), 10.24 (br s, I), 8.59 (s, 1H), 7.93 (m, 1H), 7.59 (s, 1H), 7.50 (m, 2H), 7.42 (s, 1H), 7.36 (m, 4H), 7.30 (m, 1H), 4.20 (m, 2H), 3.95 (s, 311), 3.73 (s, 2M), 3.39 (in, 2H), 3.06 (m, 2H), 2.95-2.77 (m, 511), 2.35 (m, 1H), 2.15 (m, 21), 1.45 (ma, 2H). LC/MS Caled for [+1iH] 616.2, found 616.2. Alternatively, the free base was converted to the acetate salt by dissolving the free base in a mixture of MeOH and CH 2

CI

2 to which was added 3 equivalents of acetic acid. The resulting mixture was concentrated in vacuo and the resulting residue lyophilized from 1:1 AcCN:H 2 0 to give the acetate salt of 1-{3-fluoro-4-[6-methoxy-7-(2-methyl-octahydro cyclopenta[c]pyrrol-5-ylmethoxy)-quinazolin-4-yloxy]-phenyl}-3-phenylacetyl-thiourea as a white solid. 'H-NMR (400MHz, CDC1 3 ): d 12.45 (s, 1H), 8.65 (s, 1H), 7.98 (dd, 1H), 7.50 (s, 1N), 7.40 (in, 4H), 7.29 (m, 4H), 4.17 (d, 2H), 4.05 (s, 3H), 3.75 (s, 2H), 2.93 (m, 2H), 2.80 (m, 2H), 2.72 (m, 2H), 2.53 (s, 3H), 247(m, 1H), 2.25 (m, 2H), 2.02 (s, 3H), 1.35 (m, 2H). LC/MS Caled for [M+-H] 616.2, found 616.2. Example 17 CI

H

2 N

_NO

2 HNXYr N) N HCI [0306] (6.7-Dimethoxy-guinazolin-4-vl)-(2-fluoro-4-nitro-phenyl)-amine. A mixture of 4 chloro-6,7-dimethoxy-quinazoline (548mg, 2.4mmol), 2-fluoro-4-nitro-phenylamine (392mg, 2.5mmol), AcCN (10ml), and conc'd HC1 (0.050m]) was heated to reflux for several hrs. After the reaction mixture was allowed to cool to room temperature, the resulting solids were filtered, washed with AcCN and air-dried to give (6,7-dimethoxy quinazolin-4-yl)-(2-fluoro-4-nitro-phenyl)-amine (673mgs, 80%). 1 H-NMR (400MHz, 187 WO 2005/030140 PCT/US2004/031523 DMSO): 12.18 (br 8, 1M), 8.91 (s, 1H), 8.45 (s, 1H), 8.36 (dd, 1H), 8.24 (dd, 111), 7.91 (dd, IH), 7.44 (s, 1H), 4.04 (s, 3H), 4.02 (s, 3). LC/MS Calcd for [M+HJ* 345.1, found 345.4. Example 18 F NO HF NH 2 HNN N H 2 , 10% Pd/C [0307] N'-(67-Dimethoxy-guinazolin-4-yl)-2-fluoro-benzene-1,4-diamine. (6,7 Dimethoxy-quinazolin-4-y)-(2-fluoro-4-nitro-phenyl)-amine (673mg, 1.95mmol) was dissolved in a combination of DMF (20ml) and MeOH (20ml), to which was added 10% Pd/C (227mg). The mixture was shaken under an atmosphere of H2 on a Parr hydrogenator at 40psi for 3hrs. The reaction mixture was filtered through celite and the filtrate concentrated in vacuo. The resulting residue was triturated in EtOAc/Et 2 0. The resulting solids were filtered, washed with Et 2 O, and dried under vacuum to give N'-(6,7 dimethoxy-quinazolin-4-yl)-2-fluoro-benzene-1,4-diamine (398mg, 65%) which was used in the next reaction without further purification. 'H-NMR (400Mz, DMSO): 10.80 (br s, 1H), 10.30 (br s, 1H), 8.63 (s, 111), 8.15 (s, 1H), 7.33 (s, 1H), 7.15 (m, 1H), 6.45 (m, 1H), 3.96 (s, 6H). LC/MS Calcd for [M+H]* 315.1, found 315.4. Example 19 F NH 2 4 AgSCN HN SCN NO HN A N) S "N1 N N [0308] 1-r4-(6,7-Dimethoxy-guinazolin-4-vlamino)-3-fluoro-phenyll-3-phenylactvl thiourea. Phenylacetyl chloride (0.18ml, 1.4mmol) and AgSCN (338mg, 2.0mmol) were 188 WO 20051030140 PCT/US2004/031523 combined in dry toluene (5ml) and heated to reflux for 2 hrs. The reaction mixture was allowed to cool to room temperature, the solids were filtered through celite and the filtrate concentrated in vacuo. The resulting oil was combined with N 1 -(6,7-Dimethoxy quinazolin-4-yl)-2-fluoro-benzene-1,4-diamine (398mg, 1.3mmol) in 1:1:2 EtOH:toluene:MeOH (30m]) and the mixture stirred at room temperature overnight. The resulting solids were filtered and washed with toluene, followed by hexanes. The solids were dissolved/suspended in a mixture of EtOA/MeOH. Insoluble material was filtered and the filtrate concentrated in vacuo. The resulting solids were once again dissolved/suspended in a mixture of EtOAc/MeOH. In soluble material was filtered and the filtrate concentrated in vacuo to give 1-[4-(6,7-dimethoxy-quinazolin-4-ylamino)- 3 fluoro-phenyl]-3-phenylacetyl-thiourea (105mg, 17%). 1 H-NMR (400MHz, DMSO): 12.53 (s, 1H), 11.86 (s, 1H), 11.44 (br s, 1H), 8.81(s, 11H), 8.25 (s, 1f), 7.94 (dd, 1H), 7.54 (m, 21), 7.16 (in, 5H), 7.10 (i, 11), 4.02 (s, 6H), 3.84 (s, 2H). LC/MS Caled for [M+H]* 492.1, found 492.4. Example 20 ON0 g NO O NO2 [0309] 6.7-Dimethoxy-445-nitro-pyridin-2-yloxy)-quinoline. To a round bottom flask equipped with a magnetic stir bar was added 6,7-dimethoxy-1H-quinolin-4-one (1.8 g, 8.77 mmol, 1.0 eq.), anhydrous acetonitrile (90 mL) and Cs 2 COs (3.13 g, 9.65 mmole, 1.1 eq.). The reaction mixture was stirred at room temperature for 5 minutes. Then, 2-C1-5 nitropyrdine (1.53 g, 9.65 mmol, 1.1 eq.) was added. The reaction mixture was stirred at room temperature for 16 hours. The solids were then filtered off and the filtrate was concentrated via rotary evaporation. The resulting material was taken up in EtOAc, and again the solids were filtered off. The EtOAc filtrate was concentrated. Purification was done on Biotage with solvent system EtOAc 100%. The collected pure fractions were concentrated and dried on high vacuum overnight to give 6,7-dimethoxy-4-(5-nitro pyridin-2-yloxy)-quinoline as a yellow foam solid (0.902 g, 31.4% yield). 1 H NR (400 189 WO 2005/030140 PCT/US2004/031523 MHz, CDCl3): 9.08 (d, 1), 8.74 (d, 1H), 8.60 (dd, 1H), 7.49 (s, 1H), 7.26 (d, 1H), 7.16 (s, 1H), 7.07 (d, 1H), 4.06 (s, 3H), 3.95 (s, 3H); MS (E) for C 16

H

13

N

3 0s: 328 (M+Ht). Example 21 NO2 NH2 0N ' OPW 0A

H

2 Balloon [0310] 646.7-Dimetboxy-quinolin4yloxy)-pyidin-3--yamine. To a round bottom flask equipped with a magnetic stir bar was added 6,7-dimethoxy-4-(5-nitro-pyridin-2-yloxy) quinoline (0.46 g, 1.41 mmol, 1.0 eq.) and THF (10 mL), MeOH (4 niL), DMF (2 mL), and TEA (2 mL). The 6,7-Dimethoxy-4-(5-nitro-pyridin-2-yloxy)-quinoline was dissolved completely in the above solution mixture, and was flushed with nitrogen for at least 5 minutes. The Pd/C (10% by weight) (0.090 g, 20% by weight) was then added. A balloon filled with H2 was connected to the flask after the nitrogen was vacuumed out. The reaction mixture was stirred at room temperature for 4 hours. The palladium was filtered out through Celite, and the filtrated was collected and concentrated via rotary evaporation. The resulting oi-like product was taken up into 5 mL of water and 1 mL of acetonitrile and lyophilized to yield 6-(6,7-dimethoxy-quinolin-4-yloxy)-pyridin-3-ylamine as a light brown solid (0.411 g, 98.1%). 'H NMR (400 MHz, CDCI3): 8.54 (d, UH), 7.85 (d, 1H), 7.53 (s, 1H), 7.41 (s, 1H), 7.18 (dd, 11), 6.96 (d, 1H), 6.61 (d, 1H), 4.05 (s, 311), 4.03 (s, 3H), 3.73 (s, 2M); MS (EI) for C 16

H

15

N

3 0 3 : 298 (M+H*). Example 22 HOH H H SCNN N N N N >21 0 N

N

0 'O [0311] 1-[6-(6.7-Dimethoxy-quinolin-4loxy)-pvridin-3-vll-3-phenlacetyl-thiourea. To a round bottom flask equipped with a magnetic stir bar was added 6-(6,7-dimethoxy quinolin-4-yloxy)-pyridin-3-ylamine (85 mg 0.0285 mmol, 1.0 eq.), and Phenyl-acetyl 190 WO 2005/030140 PCT/US2004/031523 isothiocyanate (256 mg, 1.44 mmoL 5.0 eq.) dissolved in EtOAc/MeOH 50:50 (2 mL). The reaction mixture was sittred at room temperature for 12 hours, and the solvent was evaporated via rotary evaporation. Purification was done on Biotage with solvent system 95% EtOAc, 4% TBA and 1% MeOH. The combined pure fractions were concentrated and dried under vacuum overnight to yield 1-[6-(6,7-dimethoxy-quinoin-4-yloxy) pyridin-3-yl]-3-phenylacetyl-thiourea as a light yellow solid (40.4 mg, 29.7%). 'H NMR (400 MHz, CDC3): 8.65 (d, 1H), 8.33 (4, 11H), 8.27 (dd, 1H), 7.35 (mn, 7H), 7.15 (d, 1H), 6.92 (d, 1f), 4.05 (s, 311), 3.99 (s, 3H), 3.76 (s, 2H); MS (BI) for CsH22N40 4 S: 475 (M+R4). Example 23 1. CICOOOEts 8 N, 2. phenethylamine, Me Me a N- 80OC MeO N [0312] N-[4-(6,7-Dimethoxy-guinolin-4-yloxy -3-fluoro-phenyll-N'-phenethyl-oxalamide. To a solution of 4-(6,7-dimethoxy-quinolin-4-yloxy)-3-fluoro-phenylamine (263 mg, 0.83 mmol) and Et 3 N (0.223 ml, 1.67 mmol) in CH 2

C

2 (10 mL) was added dropwise a solution of ethyl oxalyl chloride in CH 2 C12 (1 mL). The stirring was continued for 0.5 h at rt. The reaction mixture was then washed with aqueous saturated NaHCO 3 and dried over NaSO4. Removal of the solvent gave the crude oxamate, which was treated with neat phenethylamine (1.0 g, 8.3 mmol) at 80 *C for 3 I Purification by flash column chromatography (hexanes:EtOAc = 1:3) gave N-[4-(6,7-dimethoxy-quinolin-4-yloxy)-3 fluoro-phenyl]-N'-phenethyl-oxalamide (310 mg, 76%). 'H NMR (400 MHz, CDCl3) 6 9.35 (br s, I H), 8.70 (d, J= 6.3 Hz, 1 H), 7.83 (dd, J= 11.9, 2.5 Hz, 1 M), 7.60-7.54 (m, 2 H), 7.43 (s, 1 H), 7.38-7.32 (i, 3 H), 7.30-7.20 (m, 4 H), 6.41 (d, J = 5.3 Hz, 1 H), 4.07 (s, 3 H), 4.05 (s, 3 H), 3.67 (dt, J= 7.0, 7.0 Hz, 2 H), 2.92 (t, J= 7.2 Hz, 2 H). LC-MS: 490 [M+HJ* 191 WO 2005/030140 PCTIUS2004/031523 Example 24 H NNN Oa H 0 N [0313] N-{3-Fluoro-4-[6-methoxy-741-methyl-piperidin-4-ylmethoxy)-quinolin-4 vloxy-phenyl)N'-phenethyl-oxalamide. To a flask containing 7-benzyloxy-4-(2-fluoro-4 nitro-phenoxy)-6-methoxy-quinoline (850 mg, 2.0 mmol) was added 20 mL of 30% BBr in AcOH. The resulted solution was stirred for 4 h at rt; at this time, a large amount of precipitate formed. The crude product was filtered, washed with Et 2 O and dried in air, giving 4-(2-fluoro-4-nitro-phenoxy)-6-methoxy-7-hydroxyquinoline (609 mg, 92% yeld). [0314] To a solution of the 4-(2-fluoro-4-nitro-phenoxy)-6-methoxy-7-hydroxyquinoline (609 mg, 1.8 mmol) in DMF (9 mL) was added K 2

CO

3 (1.24 g, 9.0 mmol) and N-Boc-4 piperidinemethanol mesylate (732 mg, 2.5 mmol). The mixture was then stirred at 80 "C for 2.5 h. After it was cooled to rt, the mixture was loaded directly to a Biotage column, and eluted with solvents (hexanes:EtOAc = 1:3). The resulting product, 4-[4-(2-fluoro-4 nitro-phenoxy)-6-methoxy-quinolin-7-yloxymethyl-piperidine-1-carboxylic acid tert butyl ester, was obtained as a solid (556 mg, 56%). [0315] To a solution of 4-[4-(2-fluoro-4-nitro-phenoxy)-6-methoxy-quinolin- 7 yloxymethyl]-piperidine-1-carboxylic acid tert-butyl ester (305 mg, 0.58 mmol) in CH 2 C1z (1 mL) was added 0.4 mL of TFA. The reaction mixture was stirred for 1.5 h and the solvents were removed under reduced pressure. The crude product was treated with NaBH(OAc)3 (381 mg, 1.80 mmol) and formaldehyde (0.5 mL, 37% in H2O). The stirring was continued for 12 h. The reaction was quenched with sat. aqueous NaHCO3. 15% NaOH was added until PH = 14. The product was extracted with EtOAc. Removal of the solvent in vacuo gave the crude product, 4-(2-fluoro-4-nitro-phenoxy)-6-methoxy-7-(1 methyl-piperidin-4-ylmethoxy)-quinoline, (240 mg, 93%), which was used directly in the next reaction. [0316] To a solution of 4-(2-Fluoro-4-nitro-phenoxy)-6-methoxy-7-(1-methyl-piperidin- 4 ylmethoxy)-quinoline (240 mg, 0.54 mmol) in EtOH (20 mL) was added 10% Pd/C (50 192 WO 2005/030140 PCT/US2004/031523 mg). The mixture was then hydrogenated on a Parr hydrogenator (40 psi) for 10 h. AcOH was added to dissolve the intermediate (mostly the hydroxylamine) and the hydrogenation was continued for additional 12 h. LC-MS was used to monitor the reaction progress. The solvents were removed under reduced pressure and the resulting crude product of 3 fluoro-4-[6-methoxy-7-(1-methyl-piperidin-4-ylmethoxy)-quin6lin-4-yloxy-phenylamine (about 220 mg) was used directly in the next reaction. [0317] To a 0 "C solution of 3-fluoro-4-[6-metboxy-7-(1-methyl-piperidin-4-ylmethoxy) quinolin-4-yloxy]-phenylamine (66 mg, 0.13 mmol) and Et 3 N (0.34 mL) in CH 2

C

2 (6 mL) was added slowly ethyl oxalyl chloride (98 mg). The reaction mixture was stirred at rt for 30 min, then diluted with CH 2 C1 2 and washed with sat. aqueous NaHCO 3 . After dried over MgSO 4 and concentrated, the crude ethyl oxamate was reacted with phenethylanine (80 mg, 0.64 mmol) at 80"C for 2 h. Purification by HPLC gave product, N-{3-fluoro-4 [6-methoxy-7-(1-methyl-piperidin-4-ylmethoxy)-quinolin-4-yloxy]-phenyl}.-N'-phenethyl oxalamide (52 mg, 68% yield). 'H NMR (400 MHz) 8 9.38 (br s, 1 H), 8.48 (d, I = 5.2 Hz, 1 H), 7.83 (dd, J= 11.7, 2.6 Hz, 1 H), 7.59 (t, I = 6.2 Hz, 1 H), 7.55 (s, 1 H), 7.40-7.20 (8 H), 6.39 (d, I = 5.3 Hz, 1 H), 4.06 (d, I = 6.6 Hz, 2 H), 4.04 (s, 3 H), 3.67 (q, J = 6.8 Hz, 2 H), 2.98 (br d, J = 11.5 Hz, 2 H), 2.92 (t, J = 7.0 Hz, 2 H), 2.34 (s, 3 H), 2.10-1.80 (m, 5 H), 1.60-1.54 (m, 2 H). Example 25 -F [0318] 1-(4-Fluoro-phenylcarbamoyl)-cclopropanecarboxylic acid, The title compound was prepared based on a modified procedure of Shih and Rankin [Synthetic Communications, 1996, 26(4), 833-836]: To a mixture of cyclopropane-1,1-dicarboxylic acid (21.2 g, 0.163 mol, 1.0 eq.) in anhydrous THF (200 mL) under nitrogen was added dropwise triethylamine (16.49 g, 0.163 mol, 1.0 eq.) with stirring for 30 minutes at 0"C, followed by the addition of thionyl chloride (19.39 g, 0.163 mol, 1.0 eq.) with stirring for another 30 minutes at 0*C. To the resulting mixture under nitrogen was added dropwise a solution of 4-fluoroaniline (19.92 g, 0.179 mol, 1.1 eq.) in anhydrous TBF (100 mL) with stirring for 1.5 hours at 0"C. The reaction mixture was diluted with ethyl acetate and 193 WO 2005/030140 PCTUS2004/031523 washed with 1N NaOH. The layers were separated, and the ethyl acetate layer was concentrated in vacuo to give a brownish solid. The brownish solid was washed with small amount of cold ethyl acetate, filtered and dried under vacuum to yield 1-(4-fluoro phenylcarbamoyl)-cyclopropanecarboxylic acid as a white solid (23.71 g, 65.18%). 'H NMR (400 Mz, CD 3 0D): 7.57-7.53 (m, 2H), 7.05-7.00 (n, 2M)1.46-1.43 (in, 2H), 1.40 1.37 (m, 2H). Example 26 HO F [03191 1-(4-Fluoro-phenylcarbamovl)-cyclobutanecarboxvlic acid. To a mixture of cyclobutane-1,1-dicarboxylic acid (10.0 g, 69.4 mmol, 1.0 eq.) in anhydrous THF (100 mL) under nitrogen was added dropwise triethylamine (7.02 g, 69.4 mmol, 1.0 eq.) with stirring for 30 minutes at 0*C, followed by the addition of thionyl chloride (8.25 g, 69.4 mmol, 1.0 eq.) with stirring for another 30 minutes at C. To the resulting mixture under nitrogen was added dropwise a solution of 4-fluoroaniline (8.48 g, 76.3 mmol, 1.1 eq.) in anhydrous THF (50 mL) with stirring for 1.5 hours at 0C. The reaction mixture was diluted with ethyl acetate and extracted with 2N NaOil. The aqueous phase was titrated with 2N HCl to pH 1-2 and then extracted with ethyl acetate. The organic phase was dried with sodium sulfate and concentrated in vacuo to give 1-(4-fluoro-phenylcarbamoyl) cyclobutanecarboxylic acid as a light pink solid (5.75 g, 34.9%). 'H NMR (400 MHz, CDC1 3 w/ldrop CD 3 OD): 7.53-7.48 (m, 211), 7.06-7.00 (m, 211), 2.81-2.63 (m, 411), 2.14 2.02 (m, 2). Example 27 HOH HO N 0 0 [0320) 1-Benzylcarbamoyl-cyclopropanecarboxylic acid. The title compound was prepared based on a modified procedure of Shih and Rankin [Synthetic Communications, 1996, 26(4), 833-836]: To a mixture of cyclopropane-1,1-dicarboxylic acid (5.0 g, 38.4 194 WO 2005/030140 PCT/US2004/031523 mmol, 1.0 eq.) in anhydrous TBF (50 mL) under nitrogen was added dropwise triethylamine (3.89 g, 38.4 mmol, 1.0 eq.) with stiring for 30 minutes at 0"C, followed by the addition of thiohyl chloride (4.57 g, 38.4 mmol, 1.0 eq.) with stirring for another 30 minutes at 0"C. To the resulting mixture under nitrogen was added dropwise a solution of benzylamine 5 (4.53 g, 42.3 mmol, 1.1 eq.) in anhydrous THF (25 mL) with tiring for 1.5 hours at 0"C. The reaction mixture was diluted with ethyl acetate and extracted with 2N NaOH (to pH 10). The aqueous phase was titrated with 2N HCl to pH 1-2 and then extracted with ethyl acetate. The organic phase was dried with sodium sulfate and concentrated in vacuo to give 1-Benzylcarbamoyl-cyclopropanecarboxylic acid as a white solid (4.39 g, 52.15%). 1H NMR (400 MHz, CDCIs): 8.44 (br s, 1H), 7.37-7.33 (m, 2H1), 7.32-7.26 (m, 3H), 1.82-1.70 (m, 4H). Example 28 HO N [0321] 1-Phenylcarbamoyl-cvcloprpanecarboxvic acid. To a mixture of cyclopropane 1,1-dicarboxylic acid (5.29 g, 40.7 mmol, 1.0 eq.) in anhydrous THF (50 mL) under nitrogen was added dropwise triethylamine (4.12 g, 40.7 mmol, 1.0 eq.) with stirring for 30 minutes-at 0"C, followed by the addition of thionyl chloride (4.84 g, 40.7 mmol, 1.0 eq.) with stirring for another 30 minutes at 0"C. To the resulting mixture under nitrogen was added dropwise a solution of phenylamine 9 (4.17 g, 44.8 mmol, 1.1 eq.) in anhydrous TBF (25 mL) with stirring for 1.5 hours at 0"C. The reaction mixture was diluted with ethyl acetate and extracted with 2N NaOH (to pH >10). The aqueous phase was titrated with 2N HCI to pH 1-2 and then extracted with ethyl acetate. The organic phase was dried with sodium . sulfate and concentrated in vacuo to give 1-phenylcarbamoyl cyclopropanecarboxylic acid as a white solid (5.08 g, 60.8%). 1H NMR (400 MHz, CDCl 3 ): 10.50 (br s, IH), 7.56-7.54 (m, 2H), 7.35-7.31 (m, 2H), 7.15-7. 10 (m, 11), 1.94 1.91 (m, 2H), 1.82-1.79 (m, 2H). 195 WO 2005/030140 PCT/US2004/031523 Example 29 0 C] - NH (COCI)21 DMF A N QN:" [0322] 7-Benzvloxv-4-chloro-6-methoxy-guinoline. Dry DMF (8.0ml, 103mmoI) was dissolved in dry CHC 3 (40ml) and cooled in an ice bath. Oxalyl chloride (9.001, 105mmol) in CH 2 Cl 2 (10ml) was added dropwise with stirring at OC. When the bubbling had ceased, this solution was added slowly to an ice-cold solution of 7-benzyloxy- 6 methoxy-3H-quinazolin-4-one (10.0g, 35.4mmol) in dry CHC1 3 (60ml) and the mixture was then heated to reflux for 2-3hrs. After cooling to room temperature, H20 (100ml) was added and the phases were separated. The aqueous phase was further extracted with

CHC

3 (2x). The combined CHCl3 extractions were washed with sat'd NaCI (lx), dried (Na 2

SO

4 ) and concentrated in vacuo. The resulting residue was purified by flash chromatography (1:1 hexanes:EtOAc, followed by 100%EtOAc) to give 7-benzyloxy- 4 chloro-6-methoxy-quinoline (5.llg, 48%). LC/MS Calcd for [M+H 301.1, found 301.1. Example 30 10% Pd/C, EtOH E~n'lI-C O N 89% [03231 Cyclopropane-1,1-dicarboxylic acid [3-fluoro-4-(7-hydroxy-6-methoxy-uinolin 4-vloxv)-phenyll-awide(4-fluoro-phenyl)-amide. To a solution of cyclopropane-1,1 dicarboxylic acid (4-(7-benzyloxy-6-methoxy-quinolin-4-yloxy)-3-fluoro-phenyl]-amide (4-fluoro-phenyl)-amide (1.18g, 2.0 mmol) in EtOH (20 mL) was added 1,4 cyclohexadiene (2.0 mL, 20 mmol) and 10% Pd/C (300 mg). The reaction mixture was then heated to reflux and the stirring was continued for 2 h. It was cooled to room temperature, filtered through celite and washed with MeOK The MeOH solution was then concentrated under reduced pressure. The residue was taken into EtOAc (200 xnL). 196 WO 2005/030140 PCT/US2004/031523 The EtOAc solution was washed with water, and dried over Na 2

SO

4 . Removal of the solvent under reduced pressure gave 900 mg (89%) of the crude product (90% purity by analytical HPLC), which was used in the next reaction without further purification. Example 31 HF OH F DIAD, PhaP, CHpcfa HO ,O [0324] N-(4-((7-((2-(Diethylamino)ethylloxvl-6-(mthyoxy)quiuolin-4-vlloxy}-3 fluorophenyl)-N'-(4-fluoropheny lcyclopropane-1.1-dicarboxamide. To a mixture of cyclopropane-1,1-dicarboxylic acid [3-fluoro-4-(7-hydroxy-6-methoxy-quinolin-4-yloxy) phenyl]-amide(4-fluoro-phenyl)-amide (186 mg, 0.36 mmol) in CH 2

C

2 (10 mL) was added 2-(diethylamino)ethanol (63 mg, 0.54 mmol), and PPh 3 (141 mg, 0.54 mmol). DIAD (109 mg, 0.54 nmol) was then added as a CHzCl 2 (1 nL) solution. The resulted solution was stirred at room temperature for 2 h and the solvent was removed under reduced pressure. To the residue was added 1 N HCl (50 mL), and it was washed with EtOAc (50 mL x 2). The aqueous phase was basified by adding 15% NaOH aqueous solution until pH =11-13, and then extracted with ether (50 mL x 2). The combined organic layer was dried (MgSO4), and concentrated in vacuo. The residue was purified on preparative HPLC to give N-(4-{[7-f [2-(diethylamino)ethyloxy)-6-(methyloxy)quinolin 4-yl]oxy}-3-fluorophenyl)-N'-(4-fluom-phenyl)cyclopropane-1,1-dicarboxamide (74 mg, 34%) as a pale yellow solid. 'H NMR (400 MHvz, DMSO-d 6 ) 8 10.40 (br s, 1 H), 10.02 (br s, 1 H), 8.47 (d, J = 5.2 Hz, 1 H), 7.91 (br d, J = 13.9 Hz, I H), 7.54-7.52 (m, 2 H), 7.55 7.50 (m, 1 H), 7.52 (s, I H), 7.50-7.40 (m, 1 H), 7.41 (s, 1 H), 7.16 (br t, J = 8.7 Hz, 2 H), 6.41 (br d, J=4.7 Hz, 1H), 4.18 (t, J=6.0 Hz, 2 H), 3.94 (s, 3 1), 2.87 (br t, J=6.3 Hz, 2 H), 2.59 (q, J= 7.1 Hz, 4 H), 1.47 (br s, 4 W), 1.00 (t, J =7.0 Hz, 6 H). 197 WO 2005/030140 PCT/US2004/031523 Example 32 BnBr, K 2 0s 3 - HNO , 0 -" :X), ~11464, 0 C N0. Fe, HCO 2

NH

4 , A SOH 0 OO rb HCO 2 Et, Ox 2 - NH 2 [03251 1-(4-Benzyloxy-3-methoxyphenyl)ethanone. A solution of 4-hydroxy- 3 methoxyacetophenone (40 g, 240 mmol), benzyl bromide (31.4 mL, 260 mmol) and potassium carbonate (99.6 g, 360 mmnol) in DMF (800 mL) was heated to 40 "C overnight. The solution was cooled to room temperature, poured over ice and the resultant solid was filtered. This material was washed with water and dried to give 1-(4-benzyloxy-3 methoxyphenyl)ethanone (61 g, 99 %). [0326] 1-(4-Benzyloxy-5-methoxy-2-nitrophenyl)ethanone. A stirred solution of 1-(4 benzyloxy-3-methoxyphenyl)ethanone (51.3 g, 200 mmol) in dichloromethane (750 mL) was cooled to 0 "C. Nitric acid (90 %, 14 mL, 300 mmol) was added dropwise to the cooled solution over 20 min. Sulfuric acid (96.2 %, 16.3 mL, 300 mmol) was then added dropwise over 40 min at 0 *C. Additional nitric acid (9.4 mL, 200 mmol) was added dropwise over 20 min. The reaction mixture was washed with water (3 x 200 mL), and saturated sodium bicarbonate (4 x 200 mL, or until neutral). The organic layer was dried over Na 2

SO

4 and concentrated. The crude mixture was recrystallized from DMF to give 1-(4-benzyloxy-5-methoxy-2-nitrophenyl)ethanone (36 g, 60 %). 'H NMR (400 MHz, CDCl 3 ): 8 7.65 (s, 111), 7.45-7.33 (m, 511), 6.74 (s, 1H), 5.21 (s, 2H), 3.97 (s, 311), 2.49 (s, 3H). [0327) 1-(2-Amino-4-benzyloxy-5-methoxyphenyl)ethanone. A mixture of iron powder (27 g, 0.48 g atoms), ammonium formate (31 g, 500 mmol), 1-(4-benzyloxy-5-methoxy-2 nitrophenyl)ethanone (36 g, 120 mmol), toluene (500 mL) and water (500 mL) was heated to reflux overnight. The mixture was filtered through elite and washed with ethyl acetate. The combined organic layers were washed with water and brine. The organic layer was 198 WO 2005/030140 PCTJS2004/031523 dried oer Na 2

SO

4 and concentrated to afford 1-(2-amino-4-benzyloxy-5 methoxyphenyl)ethanone (29.3 g, 90 %). 'H NMR (CDCI): a 7.41-7.30 (m, 5H), 7.13 (8, 1H), 6.16 (br s, 2H), 6.10 (s, I), 5.13 (s, 2H), 3.83 (s, 3), 2.51 (s, 3M). LC/MS (M+H= 272). [0328] 7-Benzyloxy-6-methoxyquinolin-4-oL Sodium ethoxide (74.8 g, 1.1 mol) was added to a solution of 1-(2-amino4-benzyloxy-5-methoxyphenyl)ethanone (29.3 g, 108 mmol) in DM8 (700 mL) and stirred for 30 min. Ethyl formate (44 mL, 540 mmol) was added and the mixture was stirred oveight (in case of incomplete reaction, additional sodium ethoxide can be added and the reaction monitored by LC/MS). After the reaction was complete, the mixture was diluted with water (40 mL) and acidified to neutral pH with 1M HCL The solid was filtered, washed with water and dried to afford 7-benzyloxy 6-methoxyquinolin-4-ol (22 g, 72%). 'H NMR (400 MHz, CDC13): 5 10.7 (br s, 1H), 7.70 (s, 1H), 7.49-7.46 (t, 1H, 7.43-7.41 (br d, 2B), 7.37-7.33 (t, 2H), 7.30-7.28 (d, 11), 6.84 (s, 1H), 6.21-6.19 (d, 1H), 5.21 (s, 2H), 3.96 (s, 3H). LC/MS (M+H= 282). [0329] 7-Benzyloxy-4-chloro-6-methoxyguinoline. Phosphoms oxychloride (300 mnL) was added to 7-benzyloxy-6-methoxyquinolin-4-o1 (40 g, 140 mmol) and the mixture heated to reflux for 2 I. The mixture was carefully poured into a mixture of ice and sodium carbonate. The solution was adjusted to pH 8 with the addition of solid sodium bicarbonate and stired at room temperature overnight. The solid was filtered and washed with water and dried to give 7-benzyloxy-4-chloro-6-methoxyquinoline as a pale brown solid (40.2 g, 95%). 1H NMR (400 MHz, d 6 -DMSO): 8 8.61 (s, 1H), 7.57-7.37 (m, 8H), 5.32 (s, 2H), 3.98 (s, 3H); 13 C NMR (100 MHz, d4-DMSO): 6 152.4, 151.5, 148.5, 146.2, 139.6, 137.0, 129.2, 128.8, 121.7, 120.4, 110.1, 101.9, 70.8, 56.5; IR (cm): 2359, 2341, 1506, 1456, 1435, 1252, 1227, 1146, 999, 845, 752, 698,667; LC/MS (M+H = 300). Example 33 080 2 CF Bn [0330] Trifluoromethanesulfonic acid 7-benzyloxy-6-methoxy-quinolin4-yl ester. To a dry 2L RBF containing 7-benzyloxy-6-methoxyquinolin-4-oI (75.3 g, 267 mmol) was added DCM (1 L), 4-dimethylaminopyridine (3.28 g, 26.8 mmol) and 2,6-lutidine (62 mL, 199 WO 2005/030140 PCT/US2004/031523 534 mmol). The mixture was cooled to -20*C by controlled addition of dry ice to an acetone bath. Trifluoromethanesulfony chloride (37 mL, 350 mmol) was added dropwise to the cooled solution with magnetic stirring over 25 minutes. After addition was complete, the mixture was stirred in bath for 20 minutes, then at room temperature for 3 hours. LCMS indicated reaction completion. The reaction mixture was concentrated in vacuo and placed under high vacuum to remove residual 2,6-lutidine. To the resulting brown solids was added methanol (3.5 L). The resulting slurry was stirred with mechanical stirrer for 30 min before adding water (1.5 L). The solids were isolated by filtration, followed by a water wash. The resulting solid was dried under high vacuum overnight yielding trifluoromethanesulfonic acid 7-benzyloxy-6-methoxy-quinolin-4-yl ester as a light brown solid (92.2 g, 83.8%). 'H1 NMR (400MHz, DMSO, d6): 5 8.82 (d, 1H1), 7.67 (s, 1H), 7.59 (d, 1H), 7.54-7.52 (m, 2H), 7.46-7.42 (m, 2H), 7.39-7.36 (m, l), 7.23 (s, 1), 5.35 (s, 2H), 3.97 (s, 3M). LCIMS: M+H = 414. Example 34

OSO

2

CF

3 ':aN [0331] Trifluoromethanesulfonic acid 6,7-dimethoxyguinolin-4-vl ester from 6,7 Dimethoxy-guinolin-4-ol. To a dry 1L RBF containing 6,7-dimethoxy-quinolin-4-ol (20.9 g, 102 mmol), which can be prepared according to the procedure of Riegel, B. (J. Amer. Chem. Soc. 1946, 68, 1264), was added DCM (500 mL), 4-dimethylaminopyiddine (1.24 g, 10 mmol) and 2,6-lutidine (24 mL, 204 mmol). The mixture was vigorously stirred at RT. Trifluoromethanesulfonyl chloride (14 mL, 132 mmol) was added dropwise to the solution. After addition was complete, the mixture was stirred ice bath for 2 to 3 hrs. On LC/MS indicating the reaction completion, the reaction mixture was concentrated in vacuo and placed under high vacuum to remove residual 2,6-lutidine. To the resulting brown solids was added methanol (250 mL). The resulting slurry was stirred for 30 min before adding water (1 L). The solids were isolated by filtration, followed by a water wash. The resulting solid was dried under high vacuum overnight yielding trifluoromethanesulfonic acid 6, 7-dimethoxy-quinolin-4-yl ester as a light brown solid (27 g, 80%). lH NMR (400MHz, DMSO, dQ): 5 8.82 (d, 1H), 7.59 (m, 2H, 7.20 (s, 1H), 3.97 (d, 6H). LCIMS: M+H = 338. 200 WO 2005/030140 PCT/US2004/031523 Example 35 Hnt Bn N02 HCO H4 nNH2 NtroBOON HBn H 2

NH

4 H2 IPr 2 NE N A HBr CyOP~ N 002 g0 H4), HaHOAc tax>(D BnO [0332] 1-Benzyloxy-2-fluoro-4-nitrobenzene. A solution of 2-fluoro-4-nitrophenol (50.0 g, 318 mmol), benzyl bromide (42 mL, 350 mmol) and potassium carbonate (66.0 g, 478 mmol) in DMF (200 inL) was heated to 40 "C overnight. The solution was cooled to room temperature, poured over ice and the resultant solid was filtered. This material was washed with water and dried to give 1-benzyloxy-2-fluoro-4-nitrobenzene (75.0 g, 95 %). 'H NNM (400 MHz, 4-DMSO): 88.19-8.11 (m, 2W), 7.53-7.37 (m, 6H), 5.36 (s, 2H); "C NMR (100 MHz, d 6 -DMSO): 5 152.8, 152.4, 149.9, 140.9, 136.1, 129.3, 129.1, 128.7, 122.0, 115.2, 112.8, 112.6, 71.6; IR (cim?): 1499, 1346, 1279, 1211, 1142, 1072, 986, 885, 812, 789, 754, 742, 700, 648, 577. [0333] 4-Benzyloxy-3-fluoroaniline. A mixture of iron powder (45.2 g, 0.809 g atoms), ammonium formate (53.6 g, 0.850 mol), 1-benzyloxy-2-fluoro-4-nitrobenzene (50.0 g, 0.200 mol), toluene (400 mL) and water (400 mL) was heated to reflux overnight. The mixture was filtered through Celite and washed with hot ethyl acetate. The combined organic layers were washed with water and brine, then dried over sodium sulfate and concentrated to afford 4-benzyloxy-3-fluoroaniline (44 g, 100 %). 'H NMR (400 MHz, d 6 -DMSO): 8 7.43-7.26 (m, 5H), 6.90 (dd, 1H), 6.49 (dd, 11), 6.34 (m, 111), 4.99 (br s, 2H), 4.98 (s, 2M); 3 C NMR (100 Mz, drDMSO): 5 171.1, 155.1, 152.7, 144.9, 138.0, 137.2, 129.6, 129.0, 128.5, 118.9, 110.0, 102.9, 72,5; IR (cmt): 1510, 1454, 1277, 1215, 1126, 1007,957, 843, 800, 789,739,694,604; LC/MS (M+H= 218). [0334] Bthyl [(4-benzyloxy-3-fluorophenvl)aminol(oxo)acetate. Ethyl oxalyl chloride (44 mL, 390 mmol) was added to a solution of 4-benzyloxy-3-fluoroaniline (44 g, 180 mmol) in diisopropylethylamine (69 i, 400 mmnol) and stirred at room temperature for 15 min. The mixture was extracted with dichloromethane and washed with water and brine. The organic layer was dried over sodium sulfate and concentrated to afford ethyl [(4 201 WO 2005/030140 PCTIUS2004/031523 benzyloxy-3-fluorophenyl)amino](oxo)acetate (58.4 g, 100 %). '11 NMR (400 MHz, do DMSO): 8 10.87 (s, 1H), 7.73 (d, 1), 7.69 (d, 1M, 7.53 (d, 1H), 7.46-7.40 (in, 4H), 5.17 (s, 2H), 4.31 (q, 2H), 1.31(t, 3H); IR (cmu'): 1732, 1705, 1558, 1541, 1508, 1456, 1273, 1186, 1167, 1101,999,858,741,694; LCMS (M+H=318). [0335] N-(4-Benzvloxy-3-floupihenvl-N'-(2-phenylethyl)ethanediamide. Phenethyl amine (33 mL, 520 mmol) was added to ethyl [(4-benzyloxy- 3 fluorophenyl)aumino](oxo)acetate (81 g, 260 mmol) and the mixture was sonicated at room temperature for 30 min. The resulting solid was filtered, washed with water and dried to give N-(4-benzyloxy-3-flourophenyl)-N'--(2-phenylethyl)ethanediamide (100 g, 99 %). 1H NMR (400 MHz, dr-DMSO): 8 10.72 (br s, 1H), 9.05 (m, 111), 8.78 (m, 11), 7.77 (m, 1H), 7.59 (m, 111), 7.46-7.19 (m, 8H), 5.16 (m, 211), 3.45 (m, 2H), 2.83 (in, 2H); IR (cm~ ): 2980, 2883, 1653, 1522, 1506, 1441, 1385, 1221, 1122, 951, 808, 746, 696, 584; LC/MS (M+H= 393). [0336] N-(3-Fluom-4-hydroxypheny)-N'-(2-phenvlethyl)ethanediamide. A mixture of N (4-benzyloxy-3-flourophenyl)-N'-(2-phenylethyl)ethanediamide (40 g, 100 nnol) and 38% hydrobromic acid in acetic acid (250 mL) was stirred at room temperature overnight. The resulting solid was filtered, washed with water and dried to give N-(3-fluoro-4 hydroxyphenyl)-N'-(2-phenylethyl)ethanediamide as a slightly yellow solid (30.6 g, 99 %yield). 'H NMR (400 MHz, d 6 -DMSO): 8 10.60 (s, 1H), 9.02 (t, 1H), 7.70 (d, 1H), 7.47 (d, 1H), 7.32-7.20 (m, 311), 6.91 (t, 1H), 3.43 (m, 2H), 2.81 (m, 2H); 3 C NMR (100 MHz, ds-DMSO): 8160.5, 158.8, 152.0, 149.6, 142.2, 139.8, 130.3, 129.3, 129.0, 126.8, 118.1, 117.4, 109.6,109.3 JR (cm-): 3279, 1653, 1518, 1456, 1279, 1190, 742, 696, 584; LC/MS (M+H = 303). Example 36 F NO2 F R tF QF BnOH ) ~ 13n, EDO, DMA - Z FNaH %Or# F R = NO 2

R

1 R1 = Bn PdlCEtOH

R=NH

2 Fe, HCO2NH4, A R 1 = H cylohexadiene 202 WO 2005/030140 PCT/US2004/031523 [0337] 1-Benzyloxy-2-fluoro-4-nitro-benzene. To a slurry of sodium hydride (60% dispersion is oil, 693 mmol, 27.7 g) and dimethylacetamide (600 ml) was added benzyl alcohol (462 mmol, 48 ml) dropwise with stirring under N 2 . The mixture was stirred for 1 hour at RT and then cooled to O"C. 3,4-difluoronitrobenzene (508 mmol, 56.2 ml) was added to the cooled solution and stirred for 1 hour. Reaction mixture poured onto saturated ammonium chloride solution (800 ml) and stirred for 30 minutes, filtered and washed with water. The solid was stirred in ethyl acetate (500 mL), and filtered to give 54g of product. The ethyl acetate filtrate, after concentrated in vacuo, was triturated with diethyl ether (500 mL), sonicated for 2 hours, and filtered to give another 30g of product. The other layer was concentrated and column purified using 5% EtOAc/hexanes as eluent to gave additional 15g of product. The total yield of 1-benzyloxy-2-fluoro-4-nitro benzene was 95g (83%). (Note: the product contains ca. 5% of 3,4-Bis-benzyloxy nitrobenzene, which is carried into the next step without further purification.) 1 H NMR (400Mfz, CDCl 3 ); 8 8.04-8.00 (m, 2H), 7.43-7.37 (m, 5H), 7.08 (t, IH), 5.26 (s, 2H). [0338] 4-Benzyloxy-3-fluoro-phenylamine. A mixture of 1-benzyloxy-2-fluoro-4-nitro benzene (44g, 178 mmol), toluene (400 ml), ammonium formate (35 g), iron (30 g), and water (400 ml) was heated to reflux with stiring overnight. The reaction mixture was filtered through elite and washed with ethyl acetate (400ml). The organic layer was separated and washed with brine (300 ml), dried over sodium sulfate and concentrated to give 4-benzyloxy-3-fluoro-phenylamine as an oil (33.7 g, 87%). 'H NMR (400MHz, CDC1 3 ): 87.41-7.29 (m, 5H), 6.79 (t, 1H), 6.45 (dd, 1H), 6.14 (dd, 111), 5.02 (s, 2H), 3.50 (s, 2H). LC/MS: (M+1) 218. [0339] Cyclopropane-1,-dicarboxylic acid (4-benzyloxy-3-fluoro-phenl)-amide (4 fluoro-phenvl)-amide. To a stored mixture of 4-benzyloxy-3-fluoro-phenylamine (155.3 mmol, 33.7 g), 1-(4-fluoro-phenylcmbamoyl)-cyclopropanecarboxylic acid (170.8 mmol, 38.13 g) and anhydrous dichloromethane (600 ml) was added EDCI (233.9 mmol, 44.1 g) in portions. After stirring at RT for 1 hr, the reaction mixture was diluted with saturated sodium bicarbonate (400 ml) and stirred for 30 minutes. The precipitate was filtered and air dried to give the 1 st crop of product. The biphasic filtrate was separated, and the organic phase was -washed with brine (300 ml), dried over sodium sulfate, and concentrated. The residue was taken up in DCM (100 ml), stirred for 15 minutes, and filtered to give a 2" crop of product. The combined yield of cyclopropane-1,1 dicarboxylic acid (4-benzyloxy-3-fluoro-phenyl)-amide (4-fluoro-phenyl)-amide was 64.5 203 WO 2005/030140 PCT/US2004/031523 g (98%). 'H NMR (400MHz, CDCI 3 ): 8 8.92 (br s, 111), 8.88 (br s, 1H), 7.50-7.32 (in, 8H), 7.06-7.02 (m, 3H), 6.97-6.92 (t, 1H), 5.13 (s, 2H), 1.65 (s, 4H). LC/MS: (M+1) 423. [0340] Cvclopropane-1,1-dicarboxylic acid (3-fluoro-4-hydroxv-phenyl)-amide (4-fluoro phenvl)-amide. A mixture of cyclopropane-1,1-dlcarboxylic acid (4-benzyloxy-3-fluoro phenyl)-amide (4-fluoro-phenyl)-amide (152.8 mmol, 64.5), ethanol (800 ml), cyclohexadiene (764 mmol, 71 ml), and 10% Pd/C (2 g) was refluxed for 2 hours. Reaction mixture cooled and filtered through celite and washed with methanol. The combined filtrate was concentrated and stirred in 10% EtOAc/ether (350 ml). The resulting precipitate was filtered and washed with ether to give a 1V crop of product. The filtrate was concentrated and stirred in DCM (150 ml) to give another precipitate, which was then filtered to give a 2" crop of product. The combined yield of cyclopropane-1,1 dicarboxylic acid (3-fluoro-4-hydroxy-phenyl)-amide (4-fluoro-phenyl)-amide was 43 g (85%) in 95% purity by HPLC (UV @ 254 in). 'H NMR (400Mz, DMSO-D6): 8 10.07 (br s, 11), 9.92 (br s, 1H), 9.64 (br s, 1H), 7.64-7.60 (mi, 21), 7.55-7.51 (m, I), 7.17-7.12 (m, 3H), 6.89-6.84 (t, 1H), 1.43 (s, 4H). LC/MS: (M+1) 333. Example 37 Bn+HOF : n F ,10% Pd/C EtOH, reflux, 93% HO O O F [0341] Cyclopropane-l,1-dicarboxylic acid (4-benzyloxv-phenyl)-anide (4-fluoro phenyl)-amide. To a 0 "C suspension of 4-benzyloxyaniline hydrochloride (47.0 g, 200 mmol) and 1-(4-fluoro-phenylcarbamoyl)-cyclopropanecarboxylic acid (49.1 g, 220 mmol) in CH 2 C1 2 (400 mL) was added EDCI (38.2 g, 200 mmol). Stirring was continued at rt for 2-4 h until the reaction was complete. CH 2 Cl 2 was removed under reduced pressure. HzO (300 nL) and MeOH (200 mL) were added, and the resulting mixture was stirred at rt for 30 min. After filtration and wash with H70, the solid was transferred to another flask containing 300 mL of sat. aqueous NaHCO 3 solution. The mixture was stirred for another 30 min. The solid was filtered, washed with water, and dried over night 204 WO 2005/030140 PCT/US2004/031523 on a lyophilizer, affording cyclopropane-1,1-dicarboxylic acid (4-benzyloxy-phenyl) amide (4-fluoro-phenyl)-amide (75.8g, 95% yield) as an off-white solid. [0342] Cyclopropane-1.1-dicarboxylic acid (4-fluoro-phenl)-amide (4-hydxy-phenylYh amide. To a refluxing mixture of cyclopropane-t,1-dicarboxylic acid (4-benzyloxy phenyl)-amide (4-fluoro-phenyl)-amide (46 g, 113 mmol), 10% Pd/C (2 g) in EtOH (400 mL) was added dropwise 1,4-cyclohexadiene (62.7 mL, 678 mmol). Stirring was continued for 2-5 h until the reaction was complete. The mixture was cooled to rt, filtered through celite, and washed with EtOH. The solution was then concentrated under reduced pressure. To the flask containing the crude product was added CHC1 3 (200 mL). The resulting suspension was stirred for 15 min at rt. The solid was filtered, and dried in the air to give cyclopropane-1i-dicarboxylic acid (4-fluoro-phenyl)-amide (4-hydroxy phenyl)-amide (34.4 g, 95%, yield). Example 38 H2 HO N EDCi, DMA, ri N N HO+ 0 0 HO88 3 HONO [0343] Alternate Synthesis of Cyclopropane-1,1-dicarboxylic acid (4-fluoro-pheny1) amide (4-hydroxy-phenyl)-amide. To a solution of 4-aninophenol (2.93 g, 26.9 mmol) and 1-(4-fluoro-phenylcarbamnoyl)-cyclopropanecarboxylic acid (5.00 g, 22.4 mmol) in DMA (30 mL) was added EDCI (5.15 g, 26.9 mmol). The mixture was stirred vigorously until the reaction was complete (- 3 h). With vigorous stirring, the reaction mixture was then poured into a flask containing sat. aqueous NaHCO 3 solution (200 mL). The stiiring was continued for 1 h. The resulting suspension was then filtered. The solid was washed with water (50 mL), chloroform (50 mL) and dried under vacuum, affording 1-(4-fluoro phenylcarbamoyl)-cyclopropanecarboxylic acid (6.22g, 88% yield) as a powder (>95% purity by HPLC and 'H NMR). 205 WO 2005/030140 PCTIUS2004/031523 Example 39 OH + BrC6H5 N. heat [0344] N-44-F(7-Benzyloxy-6-methoxqguinolin-4-vI)oxy}-3-fluorophenvl}-N'-(2 phenylethyl)ethanediamide. A mixture of 7-benzyloxy-4-chloro-6-methoxyquinoline (30 g, 100 mmol), N-(3-fluoro-4-hydroxyphenyl)-N'-(2-phenylethyl)ethanediamide (32 g, 106 mmol), DMAP (125 g, 1.02 mol) and bromobenzene (500 mL) was heated to reflux for 6 h. The mixture was cooled to room temperature and the bromobenzene was removed under reduced pressure. Methanol (500 mL) was added to the residue and the mixture was stirred at room temperature for 2 1. The resulting solid was filtered, washed with methanol and dried to give N-{4-[(7-benzyloxy-6-methoxyquinoln-4-yl)oxy]-3-fluorophenyl}-N' (2-phenylethyl) ethanediamide (34 g, 61 %). 'H NMR (400 MHz, d-DMSO): 5 11.05 (s, 1H), 9.15 (s, 1H), 8.47 (d, II), 8.05 (d, 1H), 7.84 (d, 1H), 7.56-6.36 (m, 13H), 6.46 (d, 1H), 5.32 (s, 2H), 3.97 (s, 3H), 3.47 (q, 2H), 2.86 (t, 21); ' 3 C NMR (100 MHz, d 6 DMSO): 5 160.5, 160.2, 159.9, 159.5, 155.2, 152.7, 152.2, 150.3, 149.6, 146.9, 139.7, 137.4, 137.3, 137.2, 137.1, 129.3, 129.2, 129.1, 129.0, 128.9, 128.7, 128.6, 126.9, 124.8, 117.9, 115.3, 109.9, 102.8, 99.8, 70.6, 56.5, 41.3, 35.2; IR (cm 1 ): 1657, 1510, 1481, 1433, 1416, 1352, 1310, 1252, 1215, 1609,986, 891, 868, 850,742, 696; LCIMS (M+H= 566). Example 40 HH [0345] N- 3-Fluoro-4-[(7-hydrox-methoxyquinoin-4-vl)oxylphenyl} -N'-(2 phenylethyl)etbanediamide. To a solution of N-{4-[(7-benzyloxy-6-methoxyquinolin- 4 206 WO 2005/030140 PCT/UJS2004/031523 y1)oxyJ-3-fluorophenyl}-N'-(2-phenylethyl)ethanediamide (32 g, 56 mmol) in methanol (200 ML), DMF (100 mL), dichloromethane (100 mL), ethyl acetate (100 mL) and acetic acid (5 mL) was added palladium hydroxide (4.2 g) and the mixture was shaken on a Par hydrogenator under a hydrogen pressure of 45 psi for 4 h. The resulting suspension was filtered through celite and the solid residue was washed with boiling dichloromethane (2 L) and acetone (2 L). The combined filtrates were evaporated to yield N-{3-fluoro-4--(7 hydroxy-6-methoxyquinolin-4-yl)oxy]phenyl)-N'-(2-phenylethyl)ethanediamide as an off white solid (25.6 g, 95 %). 1H NMR (400 MHz, d 6 -DMSO): 8 11.06 (s, 1W), 10.25 (br s, 1H), 9.12 (t, 1H), 8.40 (d, 1H), 8.01 (dd, 1H), 7.50-7.44 (m, 2H), 7.31-7.23 (m, 6H), 6.39 (d, 111), 3.95 (s, 3H), 2.85 (t, 2H), 2.50 (m, 2H); IR (cm-1): 1666, 1624, 1585, 1520, 1481, 1427, 1377, 1256, 1211, 1194, 1022, 880, 850, 839, 802, 750, 700; LC/MS (M+H=476). Example 41 -o O-b -NH HN-\ o N [0346] N-3-Fluoro-4-f 6-methoxy743-moholin-4-ylpropoxy)qnolin-4 v1loxypheny1-N'-(2-phenylethvylethanediamide. A solution of N-{3-fluoro-4-[(7 hydroxy-6-methoxyquinolin-4-yl)oxy]phenyl}-N'-(2-phenylethyl)ethanediamide (25.6 g, 54 mmol), N-(3-chloropropyl)morpholine hydrochloride (11.7 g, 592 mmol) and potassium carbonate (16.6 g, 120 mmol) in DMF (300 mL) was heated to 80 0C ovemight. Upon cooling, a majority of the DMF (250 mL) was removed on a rotary evaporator, 5% aqueous LiC1 (300 mL) was added and the mixture was sonicated at room temperature. The solid was filtered, suspended in IN HCl and washed with ethyl acetate (2 x 300 mL). The solution was adjusted to pH 14 using 2N sodium hydroxide and subsequently extracted with dichloromethane (3 x 200 mL). The organic layer was dried over sodium sulfate, filtered and evaporated to give N-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4 ylpropoxy)quinolin-4-yl]oxy)phenyl)-N'-(2-phenylethyl)ethanediamide as a yellow solid (24 g, 74 %). 'H NMR (400 MHz, CDC1 3 ): 8 9.37 (s, 111), 8.46 (d, 1H), 7.81 (dd, 1H), 7.57 (t, 1H), 7.53 (s, 1H), 7.42 (s, 2H), 7.34-7.20 (m, 6H), 6.39 (d, 11), 4.27 (t, 21), 4.03 (s, 3H), 3.71 (n, 4H), 3.65 (q, 2H), 2.91 (t, 2,H), 2.56 (br s, 4H), 2.13 (m, 2H); "C NMR (100 MHz, d 6 .DMSO): 8 160.1, 160.0, 159.5, 155.2, 152.7, 152.6, 150.2, 149.5, 147.1, 207 WO 2005/030140 PCT/US2004/031523 139.7, 137.3, 137.1, 129.3, 129.1, 126.9, 124.8, 117.9, 115.1, 109.2, 102.7, 99.6, 67.4 66.9, 56.5, 55.5, 54.1, 41.3, 35.2, 26.4; IR (cm 1 ): 1655, 1506, 1483, 1431, 1350, 1302, 1248, 1221, 1176, 1119, 864, 843, 804, 741, 700; LCIMS (M+H 603). Example 42 HQ F F FF 2,-Iutidine, reflux N OTf O Bn (0347] Cyclopropane-1,1-dicarboxylic acid F4-(7-benzyloxy-6-metlhoxy-puinolin- 4 yloxy)-3-fluoro-phenyll-amide (4-fluoro-phnyl-amide. To a flask containing cyclopropane-1,1-dicarboxylic acid (3-fluoro-4-hydroxy-phenyl)-amide (4-fluoro-phenyl) amide (2.25 g, 6.7 mmol) and trifluoromethanesulfouic acid 7-benzyloxy-6-methoxy quinolin-4-yl ester (1.87 g, 4.5 mmol) was added dry 2,6-lutidine (9 mL). The reaction mixture was heated to reflux (143C) with vigorous stirring. The reaction progress was monitored by LC-MS. 2,6-Lutidine was removed under reduced, pressure when the reaction was complete (about 6 h). The residue was treated with charcoal (1.5 g) in refluxing EtOAc (50 mL) for 15 min, and filtered through celite. The volume of the filtrate was reduced to about 20 mL and was added 20 mL of 1 N HC. The cude product precipitated as the HCI salt, which was filtered and washed with EtOAc and H20 (88% purity by analytical HPLC). The HC salt was free-based with saturated aqueous NaHCO3 solution. Further purification by column chromatography (hexans:EtOAc = 1:4) gave cyclopropane-1,1-dicarboxylic acid [4-(7-benzyloxy-6-methoxy-quinolin-4-yloxy)-3 fluoro-phenyl]-anide (4-fluoro-phenyl)-amide as an off-white solid (1.3 g, 48% yield. IH NMR (400 MHz, DMSO, dQ): 10.41 (s, IH), 10.02 (s, 1H1), 8.48 (d, 1H), 7.92 (dd, 1H), 7.65 (m, 2H), 7.54 (m, 5H), 7.41 (m, 4H), 7.17 (m, 2H), 6.43 (d, 1H), 5.32 (s, 211), 3.97 (s, 3H), 1.48 (m, 411). LC/MS Calod for [M+HJ 596.2, found 596.3. 208 WO 2005/030140 PCT/US2004/031523 Example 43 F NO Ol N 0 0 F HO N [0348] Cyclopropane-1,1-dicarboxylic acid [3-fluoro-4-(7-hydroxy-6-methoxv.uinolin 4-vloxy)-phenyl-amide (4-fluoro-phenvl)-amide. To a solution of the cyclopropane-1

,

1 dicarboxylic acid [4-(7-benzyloxy-6-methoxy-quinoin-4-yloxy)-3-fluoro-phenyl]-amide (4-fluoro-phenyl)-amide (22.4 g, 37.6 mmol) in EOH (340 mL) was added 1,4 cyclohexadiene (35 mL, 376 mmol) and 10% Pd/C (2.08 g). The reaction mixture was then heated at 65"C with stirring for 3 h (Caution: H gas is released from the reaction). It was then allowed to cool to room temperature, and filtered through celite follwed by a MeOH wash. The solution was then concentrated under reduced pressure. The yellow residue was taken into EtOAc (1 L). The EtOAc solution was washed with water (lX), brine (2X), dried over MgSO 4 and concentrated in vacuo. Cyclopropane-1,1-dicarboxylic acid [3-fluoro-4-(7-hydroxy-6-methoxy-quinolin-4-yloxy)-phenyl]-amide (4-fluoro phenyl)-amide was obtained as a yellow solid (17.3 g, 91.1% yield), which were carried on to the next reaction without further purification. 'H NMR (400 MHz, DMSO, d6): 10.39 (s, 1H), 10.15 (s, I), 10.00 (s, 1H), 8.38 (d, 1H), 7.88 (dd, 1H), 7.63 (m, 2H), 7.50 (m, 2H), 7.40 (t, 1M), 7.27 (s, 1H), 7.14 (n, 2M), 6.33 (d, 111), 3.95 (s, 3H), 1.47 (m, 41). LC/MS Calkd for [M+iH] 4 506.2, found 506.3. Anal. UPLC: 99.4% pure. Example 44 N. O N O F L~jo F N' N H [0349] N-3-fluoro-4-({6-(metyloxy)-7-[(3-morpholin-4-lpropylloxv quinolin-4 yloxyhenyll-N-(4-fluoropheny lcyclopropane-1.1-dicarboxamide. To a mechanica ll y stirred slurry of cyclopropane-I,1-dicarboxylic acid [3-fluoro-4-(7-hydroxy-6-methoxy quinolin-4-yloxy)-phenyll-amide (4-fluor-phenyl)-amie (16.6 g, 32.8 mmol) and 209 WO 2005/030140 PCT/US2004/031523 potassium carbonate (13.6 g, 98.6 mmol) in DMF (250 mL) was added 4-(3 chloropropyl)-morpholine hydrochloride (13, 7.92 g, 39.6 mmol). The resulting mixture was heated at 90"C for 5 hours (until phenol completely consumed). The reaction mixture was allowed to cool to room temperature, then dumped into water (900 mL), followed by extraction with EtOAc (3X). The combined extracts were washed with 5% LiC (aq.) (3X) and brine (iX) followed by drying over MgSO4 and concentration in vacuo. The crude (18.8g) obtained as brown solid was further purified by flash chromatography [silica gel, 4-stage gradient system: 1) EtOAc; 2) EtOAcMeOH:7N NHaiMeOH (95:5:0.5); 3) DCM:MeOH:7N NH3I/MeOH (95:5:0.5); 4) DCM:MeOH: 7N NH 3 /MQOH (93:8:1)], affording N-[3-fluoro-4-({6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]quinolin- 4 yl}axy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide was obtained as an off white solid (15.0 g, 72% yield). 1H NMR (400 MHz, DMSO-d6): 10.41 (s, 1H), 10.02 (s, 1H), 8.47 (d, IH), 7.91 (dd, 1H), 7.65 (m, 21), 7.53 (m, 2H), 7.42 (t, 1M), 7.40 (s, 11), 7.16 (m, 2H), 6.42 (d, 111), 4.20 (t, 2H), 3.96 (s, 3H), 3.59 (t, 4H), 2.47 (t, 2H), 2.39 (br, s, 4H, 1.98 (m, 2M), 1.48 (M, 4). LC/MS Calcd for [M+H]+ 633.3, found 633.0. Example 45 HX- 0 0 Q F DMAC F A- N K 2 C0s {0350] Cyclopropane-1,1-dicarboxvlic acid r4-(7-benzyloxy-6-.methoxy-quinazolin-4 yloxv)-3-fluoro-phenyll-amide (4-fluoro-phenvl)-amide: A mixture of 7-benzyloxy-4 chloro-6-methoxy-quinazoline (5 g, 16.67 mmol), cyclopropane-1,1-dicarboxylic acid (3 fluoro-4-hydroxy-phenyl)-amide (4-fluoro-pheny])-amide (8.3 g 25 mmol), potassium carbonate (125 mmol, 17.25 g), and dimethylacetamide (125 ml) was heated 50' C with stirring for 16h. Reaction mixture was poured onto ice/water (600 ml) and stirred for 30 minutes, and filtered. The solid was dissolved in ethyl acetate and washed with water (lx), brine, and concentrated. The crude was purified on silica get column eluting with 30% acetone in hexanes to yield cyclopropaue-1,1-dicarboxylic acid [4-(7-benzyloxy-6 210 WO 2005/030140 PCT/US2004/031523 methoxy-quinazolin-4-yloxy)-3-fluoro-phenyl]-amide (4-fluoro-phenyl)-amide (7.5 g, 76%). 'H NMR (CDCIs); 8.64 (1H, br. s), 8.55 (1H, s), 8.33 (1H, br. s), 7.74-7.71 (1H, dd), 7.54 (1H, s), 7.48-7.33 (8H, m), 7.31-7.24 (211, in), 7.06-7.02 (2H, m), 5.32 (2H, a), 4.06 (311, s), 1.77-1.74 (2, m), 1.63-1.61 (2H, m). Example 46 0 F A-) [0351] Cyclopropane-1,1-dicarboxylic acid [3-fluoro-4-(7-hydroxy-6-methoxy quinazolin-4-vloxy)-phenylamide (4-fluoro-phenl)-amide. To a mixture of cyclopropane-1,1-dicarboxylic acid [4-(7-benzyloxy-6-methoxy-quinazolin4-yloxy)-3 fluoro-phenyll-amide (4-fluoro-phenyl)-amide (7.5 g, 12.6 mmol), acetic acid (few drops), dichloromethane (50 ml) and methanol (100 ml) was added 10% Pd/C (700 mg). The mixture was agitated in hydrogen gas -(40 psi) until the reaction was complete (ca. 4 fr). The solution was filtered through celite and concentrated to give a crade product as a solid. The crude product was titurated with ether, and filtered. The filter cake was dried in vacuo to yield cyclopropane-1,1-dicarboxylic acid [3-fluoro-4-(7-hydroxy-6-methoxy quinazolin-4-yloxy)-phenyl]-amide (4-fluoro-phenyl)-amide (6.1 g, 95% yield). 'H NMR (dmso-d6): 10.86 (1H, br. s), 10.34 (1H, br. s), 10.04 (1H, br. s), 8.46 (1H, s), 7,84-7.80 (1H, dd), 7.66-7.62 (2H, m), 7.55 (111, s), 7.47-7.45 (111, m), 7.41-7.37 (1H, m), 7.24 (11, s), 7.18-7.13 (2, t), 3.98 (31, s), 1.46 (4H1, s). Example 47 0 0 F, N, O F 0 0 NN N- /H H [03521 N-[3-Fluoro-4-({ 64methyloxy)-7-[(3-morpholin-4-ylpropyl)oxylguinazolin-4 ylloxylphenyll-N'-(4-fluorophenyl)cyclopropane-1.1-dicarboxamide. To a mixture of 211 WO 2005/030140 PCT/US2004/031523 cyclopropane-1,1-dicarboxylic acid [3-fluoro4-(7-hydroxy-6-methaxy-quinazolin- 4 yloxy)-phenyl]-amide (4-fluoro-phenyl)-amide (1.5 g, 2.96 -mmol), 4-(3 hydroxypropyl)morpholine (0.623 mL, 4.5 mmol), triphenylphosphine (1.18 g, 4.5 mmol), and dichloromethane (50 mL) was added diisopropyl azodicarboxylate (0.886 mL, 4.5 mmol). The mixture was stirred at room temperature for 16 h, monitored by LCMS. After removal of solvent, the crude mixture was separated by flash column chromatography (silica), eluting with 5% methanol in dichloromethane to give N-[3-fluoro-4-(f6 (methylaxy)-7-[(3-morpholin-4-ylpropyl)oxy]quinazolin-4-yl)oxy)phenyl]-N'-(4 fluorophenyl)cyclopropane-1,1-dicarbox-amide (890 mg, 47% yield). 1HNMR (400MHz, DMSO-d6): d 10.36 (br s, 11), 10.05 (br s, 111), 8.55 (s, 111), 7.83 (m, 1H), 7.64 (m, 2), 7.57 (s, 1H), 7.44 (n, 3), 7.18 (t, 2H), 4.27 (m, 2H), 3.99 (s, 3H), 3.61 (m, 6H), 2.40 (m, 4H), 2.01 (m, 2H), 1.47 (m, 4H). LC/MS Calcd for [M+H] 634.2, found 634.3. Example 48 HO F N [0353] N-(4-{ [67-bis(methyloxykquinolin-4-ylloxylpheny1)-N'-(4-fluorophenvl)cyclo propane-1.1-dicarboxamide. To a solution of cyclopropane-1,1-dicarboxylic acid (4 fluoro-phenyl)-amide (4-hydroxy-phenyl)-amide (6.98 g, 22.2 mmol) in anhydrous 2,6 lutidine (60 mL) was added trifluoromethanesulfonic acid 6, 7-dimethoxy-quinolin-4-yl ester (5 g, 14.8 mmol). The reaction mixture was heated at 165*C in a sealed pressure tube with stirring for 18 h. The reaction mixture was concentrated on high vacuum to completely remove lutidine. The resulting solid material was dissolved in DCM (250 mL), and washed several times with 1 N sodium hydroxide to remove the excess phenol. The crude mixture was loaded on a silica gel flash column and eluted with 75% EtOAc hexanes, affording N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N'-(4 fluorophenyl)cyclopropane-1,1-dicarboxamide (3.2 g, 44%). 'H NMR (400 MHz, d 6 DMSO): 8 10.2 (s, 1H), 10.05 (s, 1H), 8.4 (s, 1H), 7.8 (m, 2H), 7.65 (m, 2H), 7.5 (s, 1H), 212 WO 2005/030140 PCTUS2004/031523 7.35 (s, 1M), 7.25 (m, 211), 7.15(im, 2H), 6.4 (s, 1H), 4.0 (d, 61), 1.5 (s, 4H). LC/MS: M+H= 502. Example 49 C [0354] 4,7-Dichloroquinoline. Phosphorus oxychloride (4nL, 429 mmol) was added to 7-chloro-4-hydroxyquinoline 2.86g, 15.9mmol) in a round bottom flask equipped with a reflux condenser. The mixture was heated to reflux for 2h, then allowed to cool to room temperature. The solution was concentrated in vacuo to a thick oil, then dumped over cracked ice. The resulting solution was neutralized with saturated NaHCO 3 (aq). The slurry was filtered and washed with water. The solids were dried under vacuum, afforded 4,7-dichloroquinoline as a white solid (2.79g, 88.5% yield). Example 50 Oa Ms N F MI ' F NL F zN~aOHBo [0355] 4-[4-(2-Fluoro-4-{ [1-(4-fluoro-phenylcarbamovl-cyclopro anecarbonyl -amino phenox)-6-methoxy-quinazolin-7-vloxymethyl-piperidine-l-carboxylic acid tert-butyl ester Cyclopropane-1,1-dicarboxylic acid [3-fluoro-4-(7-hydroxy-6-methoxy-quinazolin 4-yloxy)-phenyl]-amide (4-fluoro-phenyl)-amide (325 mg, 0.64 nmol), 4 methanesulfonyloxymethyl-piperidine-1-carboxylic acid tert-butyl ester (193 mg, 0.66 mmol), K 2

CO

3 (181 mg, 1.31 mmol) were combined in DMF (5 ml) and heated to 80"C overnight The reaction was not complete and more 4-methanesulfonyloxymethyl piperidine-l-carboxylic acid tert-butyl ester (90 mg, 0.31 mmol) and K2CO3 (90 mg, 0.65 mmol) were added and heating at 800C continued for another night. The reaction mixture 213 WO 2005/030140 PCT/US2004/031523 was allowed to cool to room temperature, then diluted with EtOAc and washed with HzO (3x), sat'd NaC (1x), dried (Na2SO4) and concentrated in vacuo. The resulting crude material was purified by flash chromatography (1:1 bexanes:EtOAc, followed by 1:3 hexanes:EtOAc) to give 4-[4-(2-fluoro-4-{1[-(4-fluoro-phenylcarbamoyl) cyclopropanecarbonyl]-amino}-phenoxy)-6-methoxy-quinazolin-7-yloxymethyl] piperidine-1-carboxylic acid tert-butyl ester (273 mg, 60%). LC/MS Calcd for [M+H 704.3, found 704.4. Example 51 F HN O NNO [0356] Cyclopropane-l,1-dicarboxylic acid f3-fluoro-4-[6-methoxy-7-(piperidin-4 ylmethoxy)-guinazoHn-4-vloxv}-phenyll-amide (4-fluoro-phenyl-amide, TFA salt. 4-44 (2-Fluoro-4-{[1-(4-fluoro-phenylcarbamoyl)-cyclopropanecarbonylj-amino}-phenoxy)-6 methoxy-quinazolin-7-yloxymethyl]-piperidine--carboxylic acid tert-butyl ester (273 mg, 0.39 mmol) was dissolved in CH 2

C

2 (8 ml) to which was added TFA (8 ml) and the mixture stirred at room temperature for 1hr. The reaction mixture was concentrated in vacuo and the resulting oil triturated with Et 2 0. The resulting solids were filtered, washed with Et 2 O and dried under high vacuum to give cyclopropane-1,1-dicarboxylic acid {3 fluoro-4-[6-methoxy-7-(piperidin-4-ylmethoxy)-quinazolHi-4-yloxy]-phenyll-amide (4 fluoro-phenyl)-amide, TFA salt (222 mg, 80%). LC/MS Caled for [M+H]l 604.2, found 604.3. Example 52 F N-2 F [0357] N-{3-Fluoro-4-[(6-(methyloxy)-7-f [(1-methylpiperidin-4-vl)methylloxyqguin azolin-4-yl)oxylphenyl}-N'-(4-fluorophenvl)cyclopropane-1.1-dicarboxamide. 214 WO 20051030140 PCT/US2004/031523 Cyclopropane-1,1-dicarboxylic acid {3-fluoro4-[6-metboxy-7-(pipeddin-4-ylmethoxy) quinazolin-4-yloxy]-phenyl}-amide (4-fluoro-phenyl)-amide, TFA salt (222 mg, 0.31 mmol), H 2 0 (3 ml), 37% formaldehyde in H20 (0.18 ml) and acetic acid (27 drops) were combined in acetonitrile (9 ml) to which was slowly added triacetoxyborohydride (561 mg, 2.65 mmol). The mixture was stirred at room temperature for 1-2 hr, then diluted with 1N NaOH and H20 and extracted with CH 2

CI

2 (3x). The combined CHCl2 extractions were washed with sat'd NaCl (lx), dried (Na 2 SO4) and concentrated in vacuo. The resulting residue was dissolved in a minimum of 1:1 dioxane:EtOAc to which was added 4M HCI in dioxane (1-2 ml). The resulting solids were filtered, washed with EtOAc and dried under high vacuum to give N-{3-fluoro-4-[(6-(methyloxy)-7-{[(1 methylpiperidin-4-yl)methyl]oxy}quinazolin-4-y)oxy] phenyl)-N'-(4 fluorophenyl)cyclopropane-1,1-dicarboxamide, HC salt (167 mg, 83%). lHNMR (400MHz, DMSO-d 6 ): 8 10.40 (s, 1H), 10.17 (br s, 1H) 10.07 (s, 1H), 8.61 (s, 1M), 7.85 (m, 1H), 7.65 (m, 2H), 7.48 (m, 211), 7.42 (t, 1H), 7.16 (t, 2H), 4.12 (2, 2H), 4.00 (s, 3H), 3.46 (m, 2H), 2.99 (i, 2H, 2.73 (d, 3M), 2.13 (m, 1H), 2.01 (m, 2H), 1.63 (m, 2M), 1.47 (m, 4H). LCIMS Calcd for [M+H 618.2, found 618.3. Synthesis of Bridged Bicyclics [0358] The following describes synthesis of bridged bicyclics with appended leaving groups for use as, for example, alkylating agents. In the context of this invention, these alkylating agents are used, for example, to alkylate the quinazoline or quinolines on the 6 or '7-oxygens to make compounds of the invention. The invention is not limited to alkylation chemistry to append such bridged bicyclics, but rather the aforementioned description is meant only to be illustrative of an aspect of the invention. Example 53 [0359] 1,4:3,6-dianhydro-2-0-methyl-5-0-(methylsulfonyl)-D-glucitoi: To a solution of 1,4:3,6-dianhydro-2-0-methyl-D-glucitol (1.19g, 7.4 mmol) in dichloromethane was added pyridine (1mL, 12.36 mmol) followed by methanesulfonyl chloride (0.69mL, 8.92 mmol) and the mixture was allowed to stir at room temperature over 12 hours. The solvent was removed and the amorphous residue was partitioned with ethyl acetate and 0.1M aqueous hydrochloric acid. The aqueous phase was extracted once with additional 215 WO 2005/030140 PCT/US2004/031523 ethyl acetate and the combined organic layers were washed with saturated aqueous sodium chloride then dried over anhydrous magnesium sulfate. Filtration and concentration followed by drying in vacuo afforded 1,4:3,6-dianhydro-2-0-methyl-5-0 (methylsulfonyl)-D-glucitol (1.67g, 94% yield) as a colorless oil. GC/MS calculated for CsHuSO6: 238 (M). Example 54 [0360] 1,4:3.6-dianhydro-5-0-(phenylcarbonyl)-D-fructose ethylene glycol acetal: A solution of 1,4:3,6-dianhydro-5-0-(phenylcarbonyl)-D-fructose (2.00g, 8.06 mmol), ethylene glycol (5.00g, 80.6 mmol), and p-toluenesulfonic acid (1.53g, 8.06 mmol) in benzene (100mL) was refluxed for 90 min using a Dean-Stark Trap apparatus. The reaction mixture was diluted with ethyl acetate (100mL), washed with saturated aqueous sodium bicarbonate (2 x 50mL) then brine (50mL), and dried over anhydrous sodium sulfate. Filtration, concentration and column chromatography on silica (1:1 hexane/ethyl acetate) provided 1.44g (61% yield) of 1,4:3,6-dianhydro-5-0-(phenylcarbonyl)-D fructose ethylene glycol acetal as a colorless solid. 'H NMR (400 MHz; CDCl 3 ): 8.08 (in, 2H), 7.58 (m, 1M), 7.54 (m, 2M), 5.38 (dd, 1H), 4.97 (t, li), 4.21-4.02 (m, 7H), 3.86 (d, 1U), 3.75 (d, 111). Example 55 [0361] 14:3.6-dianhydro-D-fructose ethylene g1ycol acetal: To a solution of 1,4:3,6 dianhydro-5-0-(phenylcarbonyl)-D-fructose ethylene glycol acetal (1.44g, 4.93 mmol) in methanol (4OmL) was added 50% aqueous sodium hydroxide (0.38 g, 4.75 mmol) and the mixture was stirred at room temperature for 30 minutes. Neutralization with IM HC1, followed by concentration and column chromatography on silica (1:2 hexane/ethyl acetate) provided 0.74g (80% yield) of 1,4:3,6-dianhydro-D-fructose ethylene glycol acetal as a colorless solid. 'H NMR (400 MHz; CDC13): 4.60 (t, 11), 4.32 (m, 1D, 4.14 (d, 1), 4.05-3.98 (m, 5H), 3.82 (s, 2H), 3.62 (dd, 1H), 2.65 (d, I). [0362] 1,4:3,6-dianhydro-5-0-(methylsulfonyl)-D-fructose ethylene glycol acetal: To a solution of 1,4:3,6-dianhydro-D-fructose ethylene glycol acetal (0.74g, 3.93 mmdl) and triethylamine (L20g, 11.86 mmol) in dichloromethane (4OmL) was added 216 WO 20051030140 PCT/US20041031523 methanesulfonyl chloride (0.90g, 7.88 mmol) at U*C under nitrogen. The solution was warmed to room temperature and stirred for 13 I. Dichloromethane (5OmL) was added, and the organic layer was washed with saturated aqueous sodium bicarbonate (3OmL), water (30mL), and brine (3OmL) then dried over anhydrous sodium sulfate. Filtration and concentration provided 1.02g (97%) of 1,4:3,6-dianhydro-5-0-(methylsulfonyl)-D fructose ethylene glycol acetal as a yellow oil. 1H NMR (400 MEfz; CDCb): 5.08 (M, 1H), 4.82 (t, I), 4.13 (dd, 1H), 4.04 (m, 411), 3.93 (dd, 1H), 3.87 (d, 1H), 3.81 (d, 11), 3.13 (s, 3). Example 56 [0363] 1,4:3,6-dianhydro-2-deoxy-2-methylidene-D-arabino-hexitol: To a solution of 1,4:3,6-dianhydro-2-deoxy-2-methylidene-5-O-(phenylcarbonyl)-D-arabino-hexito (329mg, 1.34 mmol) in methanol (10mL) was added 50% aqueous sodium hydroxide (95mg, 1.19 mmol) and the mixture was stirred at room temperature for 30 minutes. Neutralization with 4M hydrogen chloride in 1,4-dioxane'followed by concentration and column chromatography on silica (1:1 hexane/ethyl acetate) provided 141mg (74%) of 1,4:3,6-dianhydro-2-deoxy-2-methylidene-D-arabino-hexitol as a colorless solid IH NMR (400 MHz; CDC1 3 ): 5.37 (m, 1), 5.20 (M, 1f), 4.80 (m IH), 4.54 (m, 21), 4.43 (in, 1H), 4.26 (m, 1H), 3.95 (dd, 1H), 3.54 (dd, 1H), 2.70 (d, 1H). [0364] 1,4:3,6-dianhydro-2-deoxv-2-methylidene-5-0-(methylsulfonyl)-D-arabino hexitol: To a solution of 1,4:3,6-dianhydro-2-deoxy-2-mrethylidene-D-arabino-hexito (135mg, 0.95 mmol) and triethylamine (288mg, 2.85 mnol) in dichloromethane (10iL) was added methanesulfonyl chloride (222mg, 1.94 mmol) at 00C under nitrogen. The solution was warmed to room temperature and stired for 18 h. Dichloromethane (50mL) was added and the organic layer was washed with saturated aqueous sodium bicarbonate (2 x 25mL), water (25mL) and brine (25mL) then dried over anhydrous sodium sulfate. Filtration and concentration provided 213mg (72%) of 1,4:3,6-dianhydro-2-deoxy-2 methylidene-5-O-(methylsulfonyl)-D-ambino-hexitol as a yellow oil. 'H NMR (400 MHz; CDC 3 ): 5.40 (m, 1H), 5.23 (m, I), 5.04 (m, 1H), 4.85 (m, 1f), 4.73 (t, 1H), 4.58 (m, 1H), 4.41 (m, 1H), 4.08 (dd, 1H), 3.86 (dd, 1H), 3.14 (s, 3H). 217 WO 2005/030140 PCT/US2004/031523 Example 57 [0365] 1,4:3, 6 -dianhydro-2-deoxv-5-0-(phenylcarbonvl)-L-arabino-hex-1-enitol: To a mixture of 1, 4 :3,6-dianhydro-5-0-(phenylcarbonyl)-(D)-glycitol (4.32g, 17.3 memol), triethylamine (4.91 mL, 35.3 mmol) and 4-dimethylaminopyridine (0.63g, 5.2 mnol) in dichloromethane (50 mL) at -10 0 to -15" was added trifluromethanesulfonic anhydride (3.48mL, 20.7 mmol) dropwise over ten minutes and the resulting mixture was stirred at this temperature for 3 hours. The mixture was pouted into 100 mL of ice-water and extracted with dichloromethane (3 x 50 mL). The combined organic layers were washed with brine, dried over anhydrous sodium sulfate, filtered then concentrated. The crude triflate was suspended in toluene (50 mL) followed by addition of 1,8 diazabicyclo[4,5,O]undec-7-ene (5.25 mL, 34.6 mmol) and the mixture was stirred at room temperature for 18 hours. The reaction mixture was poured into ice-water and partitioned then the aqueous portion was extracted with dichloromethane (3 x 50 nL). The combined organic portion was washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by flashed chromatography (silica gel, 5-20% ethyl acetate-hexane) to give 1,4:3,6-dianhydro-2-deoxy-5-O-(phenylcarbonyl)-L arabino-hex-1-enitol, as a white solid, 3.10g, 77% yield. 'H NMR (400MHz; CDCls): 8.08-8.06 (m, 2M), 7.61-7.57 (m, 1H), 7.56-7.43 (in, 2H), 6.62-6.61 (d, 111), 5.48-5.46 (m,1H), 5.32-5.26 (m,f1H), 5.13-5.10 (m, 2H), 4.184.14 (tr,1H), 3.61-3.56 (tr, 1H). Example 58 [0366] Methyl 3,6-anhydro-5-0-(phenvlcarbonl)-p-L-glucofuranoside: To a solution of 1,4:3,6-dianhydro-2-deoxy-5-0-(phenylcarbonyl)-L-arabino-hex-1-enitol (1.00g, 4.3 mmol) in methanol (17 mL) at -4*C was added 3-chloroperoxybenzoic acid (85%, 1.35g, 8.6 mmol), and the resulting mixture was slowly warmed to room temperature and stirred for 18 hours. The reaction mixture was concentrated, diluted with dichloromethane (50 mL), washed with saturated aqueous sodium bicarbonate solution, dried over sodium sulfate, filtered and concentrated. The residue was purified by flash chromatography (silica gel, 25-60% ethyl acetato-hexane) to give methyl 3,6-anhydro-5-0 (phenylcarbonyl)--L-glucofuranoside as a white solid, 1.03g, 83% yield. IH NMR (400MHz; CDCls): 8.11-8.08 (d, 211), 761-7.56 (tr, 1H), 7.48-7.44 (in, 2H), 5.24-5.17 218 WO 20051030140 PCT/rJS2004/031523 (m, 2H), 4.96 (s, 11), 4.57-4.56 (d, 1M), 4.27 (s, 1H), 4.22-4.18 (dd, 1H), 4.08-4.04 (dd, 111) 3.36 (s, 3H). [0367] Methyl 3.6-anhydro-2-O-methvl-5-04phenlcarbonyl-L-glucofuranoside: A mixture of methyl 3,6-anhydro-5-0-(phenylcarbonyl)-f-L-glucofaranoside (1.03g, 3.7 mmol), silver (1) oxide (0.85g, 3.7 mmol) and methyl iodide (0.34 mL, 5.5 mmol) in DMF (2 mL) was heated at 60"C for 1 hour. After cooling to room temperature the reaction mixture was diluted with ethyl acetate (50 mL), filtered over celite, adsorbed on silica gel (10g) and purified by flash chromatography (silica gel, 5-30% ethyl acetate-hexane) to give methyl 3,6-anhydro-2-O-methyl-5-O-(phenylcarbonyl)-0-L-glucofuranoside as a colorless oil, 0.82g, 76% yield. 'H NMR (400MHz; CDC1 3 ): 8.11-8.09 (d, 2H), 7.60-7.56 (m, 11), 7.46-7.44 (m, 2H), 5.24-5.20 (m, 111), 5.18-5.09 (tr, 1H), 4.99 (s, 111), 4.61-4.60 (d, 1H), 4.21-4.17 (tr, 1H), 4.08-4.03 (tr, 111), 3.81 (s, 1H), 3.40 (s, 3H), 3.57 (s, 31). [0368] Methyl 3,6-anhydro-2-0-methyl--D-idofuranoside: A solution of methyl 3,6 anhydro-2-0-methyl-5-0-(phenylcarbonyl)-p-L-glucofuranoside (820mg, 3.1mmol) and 50% sodium hydroxide (248 mg, 3.1 mmol) in methanol (1OmL) was stirred at room temperature for 30 minutes. The material was adsorbed on silica gel (5g) and passed through a short column (15% ethyl acetate in hexanes to 5% methanol in ethyl acetate) to give methyl 3,6-anhydro-2-0-methyl-a-D-idofuranoside as a colorless oil, 420 mg, 85% yield. 111 NMR (400MHz; CDCls): 5.04 (s, 11), 5.84-5.81 (tr, 111), 4.44-4.42 (tr, 1H), 4.25-4.19 (m, 11), 3.85-3.75 (m, 111), 3.49 (s, 3H), 3.43 (s, 31H), 2.75-2.72 (d, 11). [0369] Methyl 3,6-anhydro-2-O-methyl-5-0-methvIsulfonyl)-B-L-glucofuranoside: Methyl 3,6-anhydro-2-0-methyl-a-D-idofuranoside (420 mg, 2.6 mmol) was dissolved in dichloromethane (10 nL) and pyridine (0.36 mL, 3.7 mmol) at O"C. Methanesulfonyl chloride (0.14 mL,.3.1 mmol) was added and the resulting mixture was stirred at 00C for 1 hour then at room temperature for 2 hours. The reaction mixture was washed with water and saturated aqueous sodium bicarbonate solution, dried over anhydrous sodium sulfate, filtered and concentrated to give methyl 3,6-anhydro-2-0-methyl-5-0-(methylsulfonyl)-@ L-glucofuranoside as a colorless oil, 669mg, 95% yield, which was used without further purification. 219 WO 2005/030140 PCT/US2004/031523 Example 59 (0370] 3.6-anhydro-5-0-(phenyIcarbonyl)-L-glucofuranose: A mixture of osmium tetroxide (4% in water, 0.25 mL, 0.03 nmol) and N-methylmorpholine (505 mg, 4.3 mmol) in 3 mL of 50% acetone in water was warmed to 60"C. A solution of 1,4:3,6 dianhydro-2-deoxy-5-0-(phenylcarbonyl)-L-arabino-hex-1-enitol (2.00g, 8.6 mmol) in 6 mL of 50% acetone in water was added over 3 hours. During this time an additional amount of N-methylmorpholine (1.01g, 8.6 mmol) was added in small portions periodically. Upon completion of the addition process the reaction was stirred for another hour and cooled to room temperature. The crude mixture was applied to a column of silica gel and flashed (0-6% methanol in 1:1 ethyl acetate:hexane) to give 3,6-anhydro-5-0 (phenylcarbonyl)-a-L-glucofuranose as a white solid, 1.5g, 65% yield. 1H NMR (400MHz; DMSO-d): 8.01-7.95, (m, 2H), 7.68-7.66 (n, 1), 7.57-7.53 (m, 2H), 5.18 5.11 (m, 2H1), 4.854.81 (m, 1H, m), 4.37-4.35 (m, 1H), 4.05-3.96 (m, 2M), 3.85-3.83 (mn, 1H). [0371] 3,6-anhydro-2-0-methyl-5-0-(phenvlcarbonyl)-arL-glucofuranoside: 3,6 Anhydro-5-0-(phenylcarbonyl)-a-L-glucofuranose (576 mg, 2.2 mmol) was added to a mixture of sodium hydride (60% oil dispersion, 346 mg, 8.7 mmol) and methyl iodide (0.54mL, 8.7 mmol) in 5 mL of DMF at C and the resulting mixture was stirred for I hour. The reaction mixture was diluted with ethyl acetate and quenched with water (5 mL). The aqueous portion was extracted with ethyl acetate (3 x 5 mL). The combined organic portion was washed with brine, dried over anhydrous sodium sulfate, filtered, and. concentrated. The residue was purified by flashed chromatography (silica gel, 5-20% ethyl acetate in hexane) to give 3,6-anhydro-2-0-methyl-5-0-(phenylcarbonyl)-cc-L glucofuranoside as a white solid, 270 mg, 42% yield. 'H NMR (400MHz; CDCl 3 ): 8.09 8.07 (m, 21), 7.61-7.57 (m, 1H), 7.48-7.27 (M, 2), 5.25-5.22 (m, IH), 5.07-5.06 (d, 1H), 4.94-4.91 (m, 1H), 4.73-4.71 (m, 1H), 4.20-4.16 (m, 110, 3.96-3.94 (m, 1H), 3.85-3.83 (tr, 111), 3.50 (s, 3H), 3.42 (s, 3H). [0372] Methyl 3,6-anhydro-2-0-methyl-5-0-(methylsulfonyl)-a-L-glucofuranoside: A solution of methyl 3,6-anhydro-2-0-methyl-5-0-(phenylcarbonyl)-a-L-glucofuranoside (230mg, 0.92 mmol) and 50% sodium hydroxide (74 mg, 0.92 mmol) in methanol (5 rnL) was stirred at room temperature for 30 minutes. The mixture was adsorbed on silica gel (2g) and passed through a short column (15% ethyl acetate in hexanes to 5% methanol in ethyl acetate) to afford a colorless oil which was employed directly in the next step, 140 220 WO 2005/030140 PCT/US2004/031523 mg, 0.72 mmol, 95% yield. The alcohol was dissolved in dichloromethane (5 mL) and pyridine (121 pL, 1.03 mmol) was added at 0"C. Methanesulfonyl chloride (27pL, 0.88 mmol) was added and the resulting mixture was stirred at 0"C for 1 hour then at room temperature for 2 hours. The reaction mixture was washed with water and saturated aqueous sodium bicarbonate solution, dried over sodium sulfate, filtered and concentrated to give methyl 3,6-anhydro-2-0-methyl-5-0-(methylsulfonyl)-ac-L-glucofuranoside as a colorless oil, 190 mg, 96% yield. Example 60 [0373] 3.6-Anhydro-1,2-O-(1-methylethylidene)-5-0-(phenvlcarbonyl -a-L-gluco furanose: A mixture of 3,6-anhydro-5-0-(phenylcarbonyl)-o-L-glucofuranose (1.00g), 2,2-dimethoxy propane (0.63 mL), p-toluenesulfonic acid (20 mg) and benzene (10 niL) was heated at reflux for 3 hours. The reaction mixture was cooled then adsorbed on silica gel (10g) and purified by flash chromatography (silica gel, 5-35% ethyl acetate in hecanes) to give 3,6-anhydro-1,2-0-(1-methylethylidene)-5-O-(phenylcarbonyl)-oaL glucofuranose as colorless oil, 0.85g, 74% yield. 'H NMR (400MHz; CDC1 3 ): 8.08-8.06 (d, 2H), 7.59-7.56 (tr, 11), 7.46-7.42 (m, 2H), 5.99-5.98 (d, 1H), 5.35-5.31 (tr, IH), 5.10 5.08 (d, IH), 4.66-4.65 (d, 1H), 4.61-4.60 (d, IH), 4.20-4.16 (dd, IH), 3.91-3.74 (tr, 1H,), 1.50 (s, 311), 1.34 (s, 3H. [0374] 3,6-Anhydro-1,2-0-(1-methylethylidene)-5-0-(methylsulfonyl)-a-L-gluco furanose: A solution of 3,6-anhydro-1,2-0-(1-methylethylidene)-5-0-(phenylcarbony)-ac L-glucofuranose (850mg) and 50% sodium hydroxide (111 mg) in methanol (lOmL) was stirred at room temperature for 30 minutes. The mixture was then adsorbed on silica gel (5g) and passed through a short column (15% ethyl acetate in hexanes to 5% methanol in ethyl acetate) and the alcohol intermediate, 390 mg, 70% yield, was used immediately in the next step. The alcohol was dissolved in dichloromethane (10 mL) and pyridine (0.32 mL) at 0"C. Methanesulfonyl chloride (0.12 mL) was added and the resulting mixture was stirred at 0*C for 1 hour then at room temperature for 2 hours. The reaction mixture was washed with water and saturated aqueous sodium bicarbonate solution, dried over anhydrous sodium sulfate, filtered and concentrated to give 3,6-anhydro-1,2-0-(1 methylethylidene)-5-0-(methyasulfonyl)-a-L-glucofuranose as a colorless oil, 485 rng, 90% yield, which was immediately employed in the next step. 221 WO 2005/030140 PCT/US2004/031523 Example 61 [0375] (3S,8aS)-3-(Chloromethyl)hexahydro-1H-pyrrolof2,1-cif1,4oxazine: (S)-(+) Prolinol (6.00 g, 59.3 mmol) was added to epichlorohydrin (47 mL, 600 mmol) at 0"C. The solution was stired at 40"C for 0.5 h and then concentrated in vacuo. The residual oil was cooled in an ice bath and concentrated sulfuric acid (18 mL) was added dropwise with stirring. The mixture was heated at 170-180"C far 1.5 h, poured into ice (300 mL) and then basified idth sodium carbonate to pH-8. The mixture was partitioned with ethyl acetate/hexanes and filtered. The filtrate was separated and the aqueous portion was extracted twice with ethyl acetate. The combined organic portion was dried over sodium sulfate, filtered and concentrated in vacuo to afford oil that was purified by column chromatography (ethyl acetate for less polar product and then 30% methanol in ethyl acetate). (3S,8aS)-3-(Chloromethyl)hexahydro-1H-pyrrolo[2,1-c][1,4]oxazine (less polar product) (1.87 g, 10.7 mmol, 18% yield): 'H NMR (400 MHz, CDChs): 4.06 (dd, 1IH, 3.79-3.71 (m, 1H), 3.60-3.48 (m, 2H), 3.36 (dd, 1H), 3.15 (dd, 1H), 3.13-3.06 (m, 1H), 2.21-2.01 (m, 3H), 1.90-1.68 (m, 3H), 1.39-1.24 (n, 1W; MS (El) for C 8

H

14 NOCI: 176 (MB*). (3R,8aS)-3-(Chloromethyl)hexahydro-1H-pyrrolo[2,1-c][1,4]oxazine (1.54 g, 8.77 mmol, 15% yield): 'H NMR (400 MHz, CDC13): 3.94-3.77 (m, 4H), 3.55 (dd, 1H), 3.02 2.93 (m, 2M), 2.45 (dd, 1H), 2.29-2.15 (m, 2H), 1.88-1.64 (m, 31), 1.49-1.38 (m, 1H); MS (EL) for CsH 1 4 NOC: 176 (MW). [0376] Using the same or analogous synthetic techniques and/or substituting with alternative starting materials, the following were prepared: [03771 (3R.aR)-3-(Chloromethylhexahydro-1H-pyrrolo2.1-clfl,41oxazine: 'H NMR (400 MHz, CDC 3 ): 4.05 (dd, 11), 3.79-3.70 (i, 1H), 3.61-3.48 (m, 2H), 3.35 (dd, 1H), 3.15 (dd, 1H), 3.13-3.07 (m, 1H), 2,21-2.01 (m, 3M), 1.89-1.67 (m, 3H), 1.39-1.25 (m, 1H); MS (El) for CH 4 NOCL 176 (M ). [0378] (3S,8aR)-3-(Chloromethyl)hexahydro-IH-pvrrolor2,1-cl[1,4oxazine: 'H NMR (400 MHz, CDCla): 3.93-3.77 (m, 4H), 3.55 (dd, 1H), 3.02-2.93 (M, 2H), 2.45 (dd, 1H), 2.30-2.15 (m, 2H), 1.88-1.64 (m, 3M), 1.49-1.37 (i, 1H); MS (EI) for CH 14 NOCl: 176 (MW). 222 WO 20051030140 PCT/US2004/031523 Example 62 [0379] (3S,8aS)-Hexahydro-1H-pvrrolo[21-c1,41oxazin-3-ylmethyl acetate: (3S,8aS)- 3 (Chloromethyl)hexahydro-1H-pyrrolo[2,1-c][1,4]oxazine (2.30 g, 13.1 mmol) and potassium acetate (12.8 g, 131 mmol) were stirred in dimethylformamide (25 mnL) at 140"C for 20 h. The mixture was partitioned between ethyl acetate and water. The organic portion was washed twice with water, then with brine, dried over sodium sulfate, filtered and concentrated in vacuo to afford (33,8aS)-hexahydro-1H-pyrrolo[2,1 c][1,41oxazin-3-ylmethyl acetate as a brown oil (2.53 g, 12.7 mmol, 97% yield). 'H NMR (400 MHz, CDC 3 ): 4.14-4.02 (m, 3H), 3.81-3.72 (m, IH), 3.37-3.31 (m, 1H), 3.09 (dt, 1H), 3.00 (dd, 11), 2.21-2.00 (in, 3H), 2.10 (s, 3H), 1.90-1.67 (m, 3H), 1.39-1.24 (m, 1H); MS (El) for CIofIrNO3: 200 (MV ). [0380] (3S,8aS)-Hexahydro-ll-pyrolo 2,1-cl 1.41oxazin-3-ylmethanol: (3S,8aS) Hexahydro-1H-pyrrolo[2,1-c][1,4]oxazin-3-ylmethyl acetate (2.36 g, 11.9 mmol) was treated with sodium methoxide (25 wt% solution in methanol; 2.7 mL) for 0.5 h. The mixture was cooled in an ice bath and a solution of 4M HCI in 1,4-dioxane (3 mL, 12.0 mmol) was added slowly. The mixture was stirred at room temperature for 5 minutes and then was concentrated in vacuo to afford a suspension which was diluted with dichloromethane, filtered and the filtrate was concentrated in vacuo to afford (3S,8aS) hexahydro-1H-pyrrolo[2,1-c][1,4]oxazin-3-ylmethano as a brown oil (1.93 g, >100% yield). 'H NMR (400 1VJHz, CDCI 3 ): 4.05 (dd, 1), 3.73-3.65 (m, 2H), 3.62-3.56 (m, 1H), 3.39-3.34 (m, 1H), 3.10 (dt, 111), 3.00-2.95 (m, 1H), 2.24-1.98 (m, 41), 1.97-1.70 (m, 3H), 1.44-1.28 (m, 1H); MS (BI) for C 8

H

5

NO

2 : 158 (MH*). [0381] (3S,8a)-hexahydro-1H- rrolo[2,1-c[14 oxazin-3-vImethyl methanesulfonate: (3S,8aS)-Hexahydro-1H-pyrrolo[2,1-c][1,4]oxazin-3-ylmethanol (1.00 g, 6.37 mmol) was dissolved in dichloromethane (10 mL) and triethylamine (2.4 mL, 17.3 mmol) was added at 0*C followed by dropwise addition of methanesulfonyl chloride (0.93 mL, 12.0 mmol). The solution was warmed to room temperature and stirred for 1.25 h and then was concentrated in vacuo. The residue was partitioned between ethyl acetate and saturated sodium bicarbonate solution. The organic portion was washed with saturated sodium bicarbonate solution. The combined aqueous portion was extracted with ethyl acetate. The combined organic portion was washed with brine, dried over sodium sulfate, filtered and concentrated in vacuo to afford (3S,8aS)-hexahydro-1H-pyrrolo[2,1-c][1,4]oxazin-3 223 WO 2005/030140 PCT/US2004/031523 ylmethyl methanesulfonate as an orange-brown oil (1.20 g, 5.1 mmol, 80% yield). MS (EI) for CgHnNO 4 S: 236 (MH*). Example 63 (03821 Octahydro-2H-quinolizin-3-ylmethanol: Ethyl octahydro-2H-quinolizine-3 carboxylate (2.35 g 11.1 mmol) was added dropwise to a stirred suspension of lithium aluminum hydride (1 M solution in tetrahydrofuran, 33 mL, 33 mmol) in tetrahydrofuran (50 mL) at 0"C. The reaction was stirred -at room temperature for 3 h. The mixture was cooled in an ice bath and ethyl acetate (6 mL) was added slowly, followed by water (1.25 mL), 15% aqueous sodium hydroxide solution (5 mL) and water (1.25 mL). The mixture was filtered through a pad of celite and washed with ether. The filtrate was concentrated in vacuo and dried rigorously to afford octahydro-2H-quinolizin-3-ylmethanol as a yellow oil (1.66 g, 9.82 mmol, 88% yield). MS (B1) for C 10

H

19 NO: 170 (Me). [0383 Octahydro-2H-guinolizin-3-vnethvl methanesulfonate: Octahydro-2H-quinolizin 3-ylmethanol (600 mg, 3.55 mmol) was dissolved in dichloromethane (8 mL) and triethylamine (1.5 mL, 10.8 mmol) was added at 0"C followed by dropwise addition of methanesulfonyl chloride (0.56 mL, 7.16 mmol). The solution was warmed to room temperature and stirred for 1.25 h and then was concentrated in vacuo. The residue was partitioned between ethyl acetate and saturated sodium bicarbonate solution. The aqueous portion was extracted with ethyl acetate. The combined organic portion was washed with brine, dried over sodium sulfate, filtered and concentrated in vacuo to afford octahydro 2H-quinolizin-3-ylmethyl methanesulfonate as an orange oil (796 ing, 3.22 mmol, 91% yield). MS (EI) for C 1

H

21 NO3S: 248 (MHt). Example 64 [0384] (3S,8aS)-3-(Hydroxymethyl hexahvdropyr0lof1,2-lprazin-1(2H)-one: A solution of methyl 1-[(2S)-3-hydroxy-2-({[(phenylmethyl)oxy]carbonyl}amino)propyl]-L prolinate (3.50 g, 10.4 mmol) in methanol was added to 5% palladium on carbon (50 wt.% in water) in methanol and treated with hydrogen at 40 psi for 1 h. The mixture was filtered and the filtrate was brought to reflux briefly and then cooled and concentrated in vacuo to afford (3S,8aS)-3-(hydroxymethyl)hexahydropyrrolo[1,2-a]pyrazin-1(2H)-one as 224 WO 2005/030140 PCT/US2004/031523 a colorless solid (1.50 g, 8.83 mmol, 85% yield). 'H NMR (400 Mfz, CDClg): 7.28-7.22 (m, 1H), 3.83-3.75 (m, 1H), 3.69 (dd, 1H), 3.56 (dd, 11), 3.31 (t, 1H), 3.08 (dd, 1H, 2.92 (dt, 1H), 2.76-2.70 (m, 111), 2.66 (dd, 1H), 2.28-2.16 (m, 1H), 2.02-1.73 (m, 3H); MS (El) for CsHuN202: 171 (MHt). [0385] (3S.8aS)-3-({[(1,1-Dimethvlethyl)(dimethylsilylloxvmethyl)hexahydro pyrrolofl,2-alprazin-1(2=)-one: To a solution of (3S,8aS)-3-(hydroxymethyl) hexahydropyrrolo[1,2-a]pyrazin-1(2H)-one (1.49 g 8.82 mmol) in dimethylformamide (20 mL) was added triethylamine (2.45 mL, 17.6 mmol) and 4-dimethylaminopyridine (90 mg, 0.882 mmol). The solution was cooled in an ice bath and tert-butyldimethylsilyl chloride (2.66 g, 17.6 mmol) was added. The mixture was warmed to room temperature and stirred for 14 h. The mixture was concentrated in vacuo and the residue was partitioned between ethyl acetate and water. The aqueous portion was extracted twice with ethyl acetate. The combined organic portion was dried over sodium sulfate, filtered and concentrated in vacuo to afford a pale brown solid which was triturated with ethyl acetate to afford (3S,8aS)-3-({ [(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl) hexahydropyrrolo[1,2-a]pyrazin-1(2H)-one as an off-white solid (1.74 g, 5.84 nimol, 66% yield). 1H NMR (400 MHz, CDCl 3 ): 6.09-5.90 (m, 1H), 3.86-3.76 (in, 11), 3.63 (dd, 11), 3.44 (dd, 1H), 3.25 (t, 1H), 3.10 (ddd, 1H), 2.98-2.90.(m, 1H), 2.68-2.60 (m, 1H), 2.52 (dd, 1H), 2.28-218 (n, 1H), 2.06-1.95 (in, 1H), 1.93-1.74 (m, 2H), 0.90 (s, 9H), 0.07 (s, 6H); MS (E) for C, 4

H

2 aN 2 0 2 Si: 285 (MH*). [0386] (3S.8aS)-3-({ (1--Dimethylethyl)(dimethyllsilvlloxvlmethyl)-2-methylhexahydro pyrrolofl,2-alpyazin-1(2H)-one: (3S,8aS)-3-( [(1,1-Dimethylethyl)(dimethyl)silyl]oxy} methyl)hexahydropyrrolo[1,2-a]pyrazin-1(2H)-one (1.51g, 5.32mmol) in dimethylformamide (8 mL) was added to an ice-cooled suspension of sodium hydride (60 wt.% dispersion in oil; 213 mg, 5.32 mmol) in dimethylformamide (8 mL). The mixture was stirred at 0"C for 0.25 h and then iodomethane (0.332 niL, 5.32 mmol) was added dropwise. The mixture was stirred at room temperature for 0.5 h and then was stirred at 70"C for 2 h. The mixture was concentrated in vacuo and the residue was partitioned between ethyl acetate and water. The aqueous portion was extracted with ethyl acetate. The combined organic portion was dried over sodium sulfate, filtered and concentrated in vacuo to afford (3S,8aS)-3-({[(1,1-dimethylethyl)(dimetbyl)silyl]oxy}methyl)-2 methylhexahydropyrrolo[1,2-a]pyrazin-1(2H)-one as a yellow oil (1.552 g, 5.21 nnol) which was dissolved in tetrahydrofuran (20 mL) and treated with tetrabutylammonium 225 WO 2005/030140 PCT/US204/031523 fluoride (1.OM solution in tetrahydrofuran; 10.4 mL, 10.4 mmol) for 2 h at room temperature. The mixture was concentrated in vacuo and purified by column chromatography (10% methanol in dichloromethane) to afford (3SaS)- 3 (hydroxymethyl)-2-methylhexahydropyrrolo[1,2-a]pyrazin-1(21)-one as a yellow oil (496mg, 2.70mmol, 51% yield from (3S,8aS)-3-({I(1,1 dimethylethyl)(dimethyl)silylloxy} methyl)hexahydropyrrolo[1,2-apyrazin-1(2H)-one). 'H NMR (400 MHz, CDCl,): 3.98-3.93 (m, 1$, 3.86 (dd, 1H), 3.61-3.55 (m, IH), 3.29 3.25 (m, 1H), 3.09-3.03 (m, 111), 3.03-2.97 (m, 1H), 3.02 (s, 3H), 2.93 (dd, 1H), 2.87-2.79 (m, IH), 2.32-2.21 (m, 111), 2.00-1.86 (m, 2H), 1.83-1.64 (m, IH); MS (EI for

C

9

H

16

N

2 0 2 : 185 (MH*). Example 65 [0387] 1.2-Dideoxy-1-[(2S)-2-(methoxycarbonyl)-1-pyrroldinv l-2-thenlmethoxy) ggaronylaminol-D-lcerohejtl: To a solution of 2-deoxy-2-{[(phenylmethyloxy) carbonyl]amino}-D-glycero-hexopyranose (5.0 g, 0.016 mol) in methanol (500 mL) was added L-proline methyl ester hydrochloride (2.8 g, 0.022 mol) and sodium cyanoborohydride (3.4 g, 0.054 mol). The solution was heated to 64 "C for 14 h. After cooling to room temperature, the reaction mixture was concentrated in vacuo to afford 1,2-. dideoxy-1-[(2S)-2-(methoxycarbonyl)-1-pyrrolidinyl]-2-[[(phenylmethoxy)carbonyl] amino]-D-glycero-hexitol (6.81 g, 100%) as a clear and colorless oil. MS (EL) for

C

2 oHsN 2 0s: 427 (MH*). Example 66 [0388] Methyl 1-F(2S)-3-hydroxy-2-U LIhenyhnethylloxvkarbonyl laminopropyll-L prolinate: 1,2-dideoxy-1-[(2S)-2-(methoxycarbonyl)-1-pyrrolidinyl]-2-[[(phenylmethoxy) carbonyl]amino]-D-glycero-hexitol (6.81 g, 0.016 mol) was taken into water (100 mL) and the resulting solution was cooled to 0"C. Sodium periodiate (14.8 g, 0.069 mol) dissolved in water was added dropwise and the resulting mixture was stirred at 0*C for 2 h. The reaction mixture was partitioned with dichloromethane (3x100 mL), dried over anhydrous magnesium sulfate, filtered and concentrated in vacuo. The residue was taken up in methanol (200 mL) and the resulting solution was cooled to 0*C. Sodium borohydride . 226 WO 2005/030140 PCT/US2004/031523 (1.98 g, 0.052 mol) was added and the reaction mixture was stirred for 1 h at 0"C. The reaction mixture was concentrated in vacuo and partitioned with dichloromethane and saturated aqueous ammonium chloride. The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated in vacuo. The resulting crude product was purified by column chromatography (5% methanol in dichloromethane) to yield methyl 1 [(2S)-3-hydroxy-2-({[(phenylmethyl)oxy]carbonylamino)propyl]-L-prolinate (4.9 g, 92%) as a white solid. MS (El) for C 1 7

I

3

N

2 0,: 337 (MHf). [0389] Methyl 1-(2S)-3-[(methvlsulfonyl)oxvl-2-({[(phenylmethyl)oxylcarbonyl aminol propyll-L-vrolinate: Methyl l-[(2S)-3-hydroxy-2-({ [(phenylmethyl)oxy]carbonyl amino) propyl]-L-prolinate (200 mg, 0.594 mmol) was dissolved in dichloromethane (5 mL) followed by the addition of 4-(dimethylamino)pyridine (3.6 mg, 0.039 mmol) and triethylamine (0.125 mL, 0.891 mmol) and the resulting mixture was cooled to' 0 *C. Methanesulfonyl chloride (0.060 mL, 0.773 mmol) was added dropwise and the reaction mixture was stirred for 1 h at 0"C. The mixture was partitioned between dichloromthane and saturated aqueous sodium bicarbonate. The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated in vacuo to afford methyl 1-[(23)-3 [(methylsulfonyl)oxy]-2-({[(phenylmethyl)oxylcarbonyl}amino)propyl]-L-prolinate (246 mg, 100%) as a clear and colorless oiL MS (El) for CIH27N20 7 S: 415 (Mt'). Example 67 [0390] 1,1-Dimethylethyl (3aR.6aS)-5-(hydroxmethyl)hexahydrocyclopentafclpvrrole 2(1E)-carboxylate: Under a nitrogen atmosphere, borane tetrahydrofuran complex (IM in THF, 42 mL, 41.9 mmol) was diluted with tetrahydrofuran (42 mL) and cooled with an ice bath. Neat 2,3-dimethylbut-2-ene (5.0 mL, 41.9 mmol) was added in portions over 0.25 h and the solution was stirred at 0*C for 3 h. A solution of 1,1-dimethylethyl (3aR,6aS)-5 methylidenehexahydrocyclopenta[c]pyrrole-2(1f)-carboxylate (1.98 g, 8.88 mmol) in tetrahydrofuran (10 mL) was added slowly,4 and the solution was warmed to room temperature and stirred 12 h. After cooling to 0*C, 10% aqueous sodium hydroxide (17 mL, 41.7 mmol) was added slowly, followed by 30% aqueous hydrogen peroxide (13 nL, 128 mmol) and the solution was warmed to room temperature. The solvent was removed in vacuo and the solution was partitioned between water and diethyl ether. The layers were separated and the aqueous layer was further extracted (3 x 50 mL diethyl ether). The

-

227 WO 2005/030140 PCT/US2004/031523 combined organic layers were dried over anhydrous sodium sulfate, filtered and concentrated in vacuo to provide 2.04 (95%) of 1,1-dimethylethyl (3aR,6aS)-5 (hydroxymethyl)hexahydrocyclopenta[c]pyrrole-2(1B)-carboxylate, which was used without purification. 'H NMR (400 MHz, CDCls): 8.50 (broad s, 111), 3.66-3.46 (m, 3H), 3.20-3.00 (m, 2H), 2.70-2.59 (m, 2H), 2.37-2.18 (i, 1H), 2.04 (m, 1H), 1.84 (broad s, 1H), 1.70-1.55 (m, 1H), 1.46 (s, 9H), 1.17 (m, 1H), 0.93 (m, 1H). [0391] L1-Dimethylethyl (3aR,6aS)--5- {(methysulfonyl)oxlmethvllhexahydrocyclo penta rclpyrrole-2(1)-carboxylate: Metbanesulfonyl chloride (0.2mL, 2.48mmol), was added dropwise to a solution of 1,1-dimethylethyl (3aR,6aS)-5-(hydroxymethyl)hexahydro cyclopenta[c] pyrrole-2(1B)-carboxylate (0.40 g, 1.65 mmol) and triethylamine (0.69 nL, 4.95 mmol) in 20 mL dichloromethane at 0"C and the reaction mixture was stirred for 1 h at room temperature. The solvent was evaporated, the resulting crude mixture was diluted with 100 mL ethyl acetate and washed with water (30 mL), 1M aqueous sodium hydroxide, brine, 1M aqueous hydrochloric acid and brine again. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The resulting 1,1-dimethylethyl (3aR,6aS)-5-{[(methylsulfonyl)oxy]methyl)hexahydrocyclo penta[clpyurole-2(lH)-carboxylate was used without further purification. MS (El) for CuH 2 sNO5S: 320 (Mt), 264 (M-tBu). Example 68 [0392] 1.1-Dimethylethyl (3aR,6aS)-5-hydroxy)-hexahydrocclopentarcl pyrrole-2(1l) carboxylate: Sodium borohydride (0.15 g, 4.00 mmol), was added to a solution of 1,1 dimethylethyl (3aR,6aS)-5-oxo-hexahydrocyclopenta[c] pyrrole-2(11)-carboxylate (0.45 g, 2.00 mmol) in 10 mL methanol at 0*C and the reaction mixture was stirred for 1 h at this temperature. The solvent was evaporated, the crude mixture was diluted with 100 niL ethyl acetate and washed with water (30 mL), 1M aqueous hydrochloric acid and brine. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated to give 1,1-dimethylethyl (3aR,6aS)-5-(hydroxy)-hexahydrocyclopenta[c] pyrrole-2(1R) carboxylate (0.44g, 98%). 'H NMR (400 MHz, ds-DMSO): 4.08 (m, 1H), 3.40 (m, 2H), 3.30 (n, 211), 2.50 (m, 2), 1.98 (m, 2H), 1.40 (s, 9H), 1.30 (m, 211). MS (EI) for

C

12

H

21 N0 3 : 228 (Mlf). 228 WO 2005/030140 PCT/US2004/031523 [0393J 1.1-Dimethylethyl (3aR,6aS)-5-f (methylsulfonyfloxyl hexahydrocyclo pentarclpyrole-2(1f)-carboxylate: Methanesulfonyl chloride (0.18 mL, 2.33 mmol), was added dropwise to a solution of 1,1-dimethylethyl (3aR,6aS)-5-(hydmxy) hexahydrocyclopenta[c] pyrrole-2(1i)-carboxylate (0a44 g, 1.94 mmol) and triethylamine (0.81 mL, 5.81 mmol) in 10 mL dichloromethane at O"C and the reaction mixture was stirred for 1 h at room temperature. The solvent was evaporated, the resulting crude mixture was diluted with 100 mL ethyl acetate and washed with water (30 mL), brine, 1M aqueous hydrochloric acid and brine again. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated. The resulting crude 1,1-dimethylethyl (3aR,6aS)-5-{[(methylsulfonyl)oxy])hexahydrocyclopenta[clpyrrole-2(WH)-carboxylate was used without further purification. MS (BI) for CsH23NO 5 S: 306 (MI4. Example 69 [0394] 3-(Chlorometbl)hexahydro-1H-[1,4loxazino[3,4-cl[lo41xazine: A solution of (3R)-morpholin-3-ylmethanol (4.21 g, 36.0 mmol) in 2-(chloromethyl)oxirane (28.2 mL, 0.360 mol) was heated to 40"C for 3 h and then the solution was concentrated in vacua. The intermediate was cooled in an ice bath and treated with 30.0 mL of concentrated sulfuric acid. Ihe mixture was heated to 170"C for 2 h and then allowed to cool to room temperature. The mixture was poured into ice-water and solid sodium bicarbonate was carefully added until the solution was basic. 10% methanol in ethyl acetate was added and the biphasic mixture was filtered. The layers were separated and the aqueous layer was extracted (3 x 100 mL 10% methanol in ethyl acetate). The combined organic layers were dried over anhydrous sodium sulfate, filtered and concentrated in vacua. Column chromatography (SiQ 2 , 2:5 hexanes:ethyl acetate) provided 3-(chloromethyl)hexahydro 1H-[1,4]oxazino[3,4-c][1,4]oxazine 2.44g (35%) as two separated diastereomers. (3R,9aS)-3-(chloromethyl)hexahydro-1H-[1,4]oxazino[3,4-c][1,4]oxazine: (0.886 g, 13% yield): 1H NMR (400 Mz, CDC1 3 ): 3.91 (m, 3H), 3.82 (m, 1H), 3.68 (dt, 1M), 3.61 (dd, 1H), 3.47 (dd, 1H), 3.35 (t, 1H), 3.19 (t, 13), 2.80 (d, 1H), 2.54 (n, 2H), 2.40 (m, 2H); MS (El) fir CfHl4NO 2 Cl: 192 (Mfl). (3S,9aS)-3-(chloromethyl)hexahydro-1H [1,4]oxazino[3,4-c][1,4]oxazine: (1.55g, 22% yield): 1 HNMR (400 MHz, CDC 3 ): 3.85 (m, 2H), 3.73 (m, 3H), 3.50 (m, 2H), 3.29 (t, 111), 3.18 (t, 1H), 2.85 (dd, 1H), 2.64 (dd, 1H), 2.40 (m, 2H, 2.17 (t, 1H); MS (El) for CH 14

NO

2 C1: 192 (lVt). 229 WO 2005/030140 PCT/US2004/031523 [0395] Hexahydro-1H-[1,41oxazino[3,4-cl1.41oxazin-3-vhnethyl acetate; A suspension of (3R,9aS)-3-(cbloromethyl)hexahydro-1H-[1,4]oxazino[3,4-c][1,4]oxazine (1.97 g, 10.3 mmol) and potassium acetate (10.1 g, 102 mmol) in DMF (20.0 mL) was stirred at 140"C for 16 h, and then at 150"C for another 12 h. The reaction mixture was partitioned between water (250 mL) and ethyl acetate (250 mL), the organic layer was washed with 5% lithium chloride (2 x 100 mL) and brine (100 mL) then dried over anhydrous sodium sulfate and concentrated in vacuo. Column chromatography (SiOz, 1:1 hexane:ethyl acetate, then 100% ethyl acetate) afforded 0.92 g (42%) of hexahydro-1H [1,4]oxazino[3,4-c][1,4]oxazin-3-yhnethyl acetate as a yellow oil. Distinct diastereomers as described above were converted in this step to give: (3R,9aS)-hexahydro-1H [1,4]oxazino[3,4-c][1,4]oxazin-3-yhnethyl acetate: 'H NMR (400 Mz, CDCI 3 ): 4.18 (dd, 1H), 4.00 (m, 1H), 3.80 (dd, 1H), 3.68 (dt 1H), 3.60 (dd, 1H), 3.46 (m, 2H), 3.22 (t, 1H), 2.64 (dd, 1H), 2.53 (m, 2H), 2.43-2.35 (m, 211), 2.10 (s, 3H), and (3S,9aS) hexahydro-1H-[1,4]oxazino[3,4-c][1,4]oxazin-3-ylmethyl acetate: 'H NMR (400 MHz, CDC13): 4.09 (d, 2H), 3.90-3.82 (m, 2H), 3.75-3.64 (m, 3H), 3.27 (t, 1H), 3.18 (t, 111), 2.69 (dd, 1H), 2.63 (m, Il), 2.46-2.33 (n, 2H), 2.16 (t, 1H), 2.10 (s, 3H). [0396] (3R,9aS)-Hexahvdro-1H-[1,4]oxazinor3, 4-cl(1,41oxazin-3-viethyl methane sulfonate: To a solution of (3R,9aS)-hexahydro-1H-[1,4]oxazino[3,4-c][1,4]oxazin-3 yimethyl acetate (0.922 g, 4.28 mmol) in methanol (14.0 mL) was added 1.03 mL (4.50 mmol) of sodium methoxide (25% wt. in methanol) dropwise at room temperature. After. 5 min., 1.6 mL (6.43 mmol) of 4.0M hydrogen chloride in dioxane was added and a pink precipitate formed. The solution was concentrated in vacuo and the pink solid was taken up in 30.0 mL dichloromethane. This slurry was cooled in an ice bath and triethylanine (3.0 mL, 21.5 mmol) was added, followed by methanesulfonyl chloride (0.37 mL, 4.71 mmol). The resultant yellow solution was stirred for 30 minutes at room temperature. The mixture was then partitioned between dichloromethane and saturated aqueous sodium bicarbonate then the aqueous layer was extracted (3 x 50 mL dichloromethane). The combined organic layers were dried over anhydrous sodium sulfate, filtered and concentrated in vacuo to provide crude (3R,9aS)-hexahydro-1H-[1,4]oxazino[3,4 c][1,4]oxazin-3-ylImethyl methanesulfonate which was taken on to the following reaction without purification. 230 WO 2005/030140 PCT/US2004/031523 Example 70 [0397] (8aR)-6-Chloromethyltetrahydro-1 -[1,3 thiazolof43-c(14 oxazine: A solution of (4R)-1,3-thiazolidin-4-ylmethanol (0.300 g, 2.52 mmol) in 2 (chloromethyl)oxirane (2.0 mL, 25.5 mmol) was heated under nitrogen to 40C for 12 h. The solution was then cooled to room temperature and 2-(chloromethyl)oxirane was removed in vacuo. The crude intermediate was cooled in ice, and was taken up in 2.0 mL of concentrated sulfuric acid. The resulting mixture was heated to 200"C for 0.5 h then poured carefully onto wet ice, which was allowed to melt. The aqueous solution was carefully made basic using solid sodium bicarbonate and the resulting mixture was filtered using water and 10% methanol in ethyl acetate as eluent The layers were separated and the aqueous layer was extracted with 10% methanol in ethyl acetate. The combined organic layers were dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo to give 11.6 mg (2.4% yield) of crude (8aR)-6-(chloromethyl)tetrahydro- 1H [1,3]thiazolo[4,3-c][1,4]oxazine as a mixture of diastereomers which was directly taken on to the next step. Example 71 [0398] 1,1-Dimethylethyl (3-endo)-3-{2-[(methylsulfonyl)oxylethyl}-8-azabicyclof3.2.11. octane-8-carboxylate: To a solution of 1,1-dimethylethyl (3-endo)-3-(2-hydroxyethyl)-8 azabicyclo[3.2. 1]octane-8-carboxylate (30.3 mg, 1.19 mmol) in dichloromethane (4.0 nL), was added triethylamine (0.5 mL, 3.56 mmol) and the solution was cooled to 0*C under nitrogen. Methanesulfonyl chloride (0.11 mL, 1.42 mmol) was added slowly and mixture was allowed to warm to room temperature and stirred for lh. The.reaction mixture was partitioned between dichloromethane and water. The aqueous phase was extracted with dichloromethane (2 x 100 mL). The combined organic layers were dried over anhydrous sodium sulfate, filtered and concentrated in vacuo to provide 35.1 mg (89%) of 1,1 dimethylethyl (3-endo)-3-{2-[(methylsulfonyl)oxy]ethyl)-8-azabicyclo[3.2.1]octane--8 carboxylate, which was carried forward for alkylation without purification. 231 WO 2005/030140 PCT/US2004/031523 Example 72 O FN OPS-PPh N F DEADN [0399] N-[3-Fluoro4(ff7-(methyloxv)-6-[(3-morpholin-4-ylnropyl)oxyluuinazoin-4 vlloxylphenll-N'-(4-fluoropheniylkcyclopropane-1,.1-dicarboxamide. Crude cyclopropane-1,1-dicarboxylic acid [3-fluoro-4-(6-hydroxy-7-methoxy-quinazolin-4 yloxy)-phenyl]-amide (4-fluoro-phenyl)-amide (333mg, .66mN ol), PS-PPh 3 rcsin, (loading = 2.33mmol/g, 797mg, 1.86mmol), 3-morpholin-4-yi-propan-1-ol (0.2601, 1.88mmol), and DEAD (0.31m1, 1.91mmol) were combined in CH2C12 (10ml) and stirred at room temperature for 1-2hrs. The reaction mixture was filtered and the resin thoroughly washed with CH202. The filtrate was concentrated in vacuo and the resulting residue was dissolved in EtOAc and washed with H20 (4x) and sat'd NaC (1x) and then extracted with 1N HCI (3x). The combined 1N HC extractions were washed with EtOAc (2x). The acidic aqueous phase was then basified with 1N NaOH and extracted with EtOAc (3x). The combined EtOAc extractions were washed with H20 (1x), sat'd NaCl (1x), dried (NaSO4), and concentrated in vacuo. The resulting residue was purified by preparative reverse phase HPLC (25mM NH4OAc/acetonitrile) and the pure fractions were lyophilized to give cyclopropane-i,1-dicarboxylic acid {3-fLuoro-4-[7-methoxy-6-(3-morpholin-4-yl propoxy)-quinazolin-4-yloxy]-phenyl}-amide (4-fluoro-phenyl)-amide (42.6mg, 10%). 1NMR (400MHz, DMSO-d6): d 10.31 (br s, 1H), 10.05 (br s, 1), 8.55 (s, 1H), 7.84 (m, 111), 7.65 (m, 2H), 7.58 (s, 11), 7.43 (m, 3H), 7.16 (f, 2H), 4.27 (m, 2H), 4.00 (s, 313), 3.60 (in, 6H), 2.39 (m, 4H), 1.99 (m, 21), 1.47 (m, 4M). LCIMS Caled for [M+H] 634.2, found 634.1. [0400] Using the same or analogous synthetic techniques and/or substituting with alternative starting materials, the following were prepared: [0401] N-f 3-fluoro-4-[(7-(methyloxy)-6-{ [(-methylpiperidin-4-vlmethylloxyluin azolin-4-vyloxylphenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide: 'H NMR (400MHz, CDCl 3 ): 8 9.67 (s, 1H), 8.59 (s, 1H), 8.43 (s, 1H), 7.75 (d, 11), 7.52 (s, 111), 232 WO 2005/030140 PCT/US2004/031523 7.46 (m, 2H), 7.31 (s, 1H), 7.20 (m, 2H), 7.06 (t, 211), 4.04 (d, 2H), 4.03 (s, 3H), 2.98 (d, 2H), 2.34 (a, 3H), 2.12-2.1.95 (M, 5H), 1.76 (m, 2), 1.64 (m, 211), 1.57 (m, 211). Example 73 H2N '- O I HO S0C12 O OO N OH TEA TEA/THF N THF [0402] Preparation of 1-f4-(6,7-dimethoxy-quinoliu-4-vloxy)-phenylcarbamol cyclopropanecarboxylic acid. To the cyclopropyl di-carboxylic acid (449 mg, 3.45 mmol) in THF (3.5 mL) was added TEA (485 pL, 3.45 mmol). The resulting solution was tired at room temperature under a nitrogen atmosphere for 40 minutes before adding thionyl chloride (250 pL, 3.44 mmol). The reaction was monitored by LCMS for the formation of mono acid chloride (quenched the sample with MeOH and looked for corresponding mono methyl ester). After 3 hours stiring at room temperature, 4-(6,7-dimethoxy-quinolin-4 yloxy)-phenylamine (1.02 g, 3.44 mmol) was added as a solid, followed by more THF (1.5 mL). Continued to stir at room temperature for 16 hours. The resulting thick slurry was diluted with EtOAc (10 mL) and extracted with IN NaOH. The biphasic slurry was filtered and the aqueous phase was acidified with conc. HCI to pH = 6 and filtered. Both solids were combined and washed with EtOAc, then dried under vacuum. The desired product, 1-[4-(6,7-dimethoxy-quinolin-4-yloxy)-phenylcarbamoyl] cyclopropanecarboxylic acid, was obtained (962 mg, 68.7% yield, 97% pure) as a white solid. 11 NMR (DzQ/NaOH): 7.97 (d, 11), 7.18 (d, 2H), 6.76 (m, 411), 6.08 (d, 111), 3.73 (s, 311), 3.56 (s, 3H), 1.15 (d, 4H). Example 74 OH NH O O HATU/DIEA/DMA 0 N N

H

2 N F FN 233 WO 2005/030140 PCT/US2004/031523 [0403] 'N-(4f 6.7-Bis(methvloxy)guinolin4-vlloxylvphenl)-N'-[(4-fluorohenyl)methyll cyclopropane-1,1-dicarboxamide. To a solution of 1-[4-(6,7-dimethoxy-quinolin-4-yloxy) phenylcarbamoyl]-cyclopropanecarboxylic acid (74.3 mg, 0.182 mmol), 4-Fluoro benzylamine (25 pL, 0.219 mmol), DIBA (90.0 L, 0.544 mmol) in DMA (1.0 mL) was added HATU (203 mg, 0.534 mmol). The resulting solution was stirred at room temperature for 1 hour before adding dropwise to water (10 mL) with stirring. The slurry was sonicated, filtered and the solids were washed with 1 N NaOH followed by water. After air drying, the solids were further purified by prep HIPLC, affording 'N-(4-{[6,7 bis(methyloxy)quinolin-4-yIjoxy}phenyl)-N'-[(4-fluorophenyl)methyl]cyclopropane-1,1 dicarboxamide (33 mg, 35% yield, 98% pure) as a white solid. 1H NMR (DMSO, d: 10.82 (s, 1H), 8.80 (d, 1H), 8.50 (t, 1), 7.83 (d, 2M), 7.74 (s, 11), 7.56 (s, 1H), 7.30-7.38 (m, 4H), 7.15 (t, 2H), 6.80 (d, 1H), 4.32 (d, 2H), 4.04 (s, 3H), 4.03 (s, 3H), 1.42 (s, 4H). [0404] The following compounds were pepared, in a similar manner as above, from the coupling of 1-[4-(6,7-dimethoxy-quinolin4-yloxy)-phenylcarbamoyl]-cyclopropane carboxylic acid with a corresponding alkylanine or arylamine. [0405] N-(4-{6,7-Bis(methyloxy)qguinoin-4-vl oxphenvl-N'-C[ipriylmethyl)phenyllcyclopropane-1.1-dicarboxamide. 1H NMR (DMSO-d6): 10.62 (s, 1H), 8.79 (d, 1H), 8.24 (t, 1H), 7.83 (d, 2H), 7.72 (s, 1H), 7.58 (s, 1W), 7.37 (d, 2W), 6.76 (d, 1H), 4.04 (s, 3H), 4.03 (s, 3H), 3.98 (m, 2W), 3.66 (m, 2H), 349 (m, 4H), 3.25 (t, 2H), 3.13 (br., 2H), 1.42 (d, 4H1). [0406] N-(4- [6.7-Bis(methyloxy)auinoliu-4-vlloxvlphenyl)-N'-2-Wipeddin-1 ylmethyl)phenyllcyclopropane-11-dicarboxamide. 1H NMR (DMSO-d6): 10.78 (s, 1H), 10.53 (s, 1H), 8.43 (d, 1H), 8.12 (d, 1W), 7.82 (d, 2H), 749 (s, 11), 7.37 (s, 1), 7.20-7.28 (m, 3H), 7.15 (dd, 1M), 7.01 (td, 1H), 6.35 (d, 1H), 3.93 (s, 3H), 3.92 (s, 3H), 3.47 (s, 2H), 2.17 (br., 4H), 1.49 (m, 4H), 1.41 (m, 4H), 1.32 (br., 2). [0407] 'N-(4-f [6.7-Bis(methyloxv)quinolin-4-vlloxvlphenl)-N'-[2-(pyrrolidin-1 vlmethyl)phenyllcyclopropane-1,1-dicarboxamide. 1H NMR (DMSO-d6): 10.98 (s, 1H), 10.56 (s, 1H), 8.42 (d, 1H), 8.10 (dd, 1H), 7.81 (m, 2H), 7.49 (s, 1H), 7.37 (s, 1H), 7.17 7.27 (m, 4H), 7.01 (td, 111), 6.35 (d, 1H), 3.93 (s, 3H), 3.92 (s, 3H), 3.61 (s, 211), 2.30 (br., 4H), 1.47 (br., 4H), 1.43 (m, 4H). [0408] 'N-(4-{f6,7-Bis(methyloxy)quinolin-4-ylloxylphenyl)-N'-3-(morpholin-4 vLmethyl)phenylcyclopropane-1,1-dicarboxamide. 1H NMR (DMSO-d6): 10.12 (s, 11), 234 WO 2005/030140 PCT/US2004/031523 10.03 (s, 1H), 8.44 (d, 111), 7.74 (d, 2H), 7.57 (s, 1H), 7.53 (d, 111), 7.48 (s, 1H), 7.37 (s, 111), 7.21 (m, 3H), 6.98 (d, 1H), 6.40 (d, 11), 3.93 (s, 3H), 3.92 (s, 3H), 3.56 (t, 4H), 3.41 (s, 2H), 2.34 (br., 4H), 1.48 (s, 41). [0409j 'N-(4-f r6,7-Bis(methy1oxvqufioli-yxvphenv)-N'-2-(mowholin-4 ymeth1yLheuv1cyclopropane-1,1-dicarboxamide. 1K NMR (DMSO-d6): 10.54 (s, 1H), 10.47 (s, 111), 8.43 (d, 1H), 8.08 (d, 1H), 7.78 (d, 2M), 7.49 (s, 1H), 7.37 (d, 1H), 7.18 7.30 (m, 41), 7.03 (t, 11), 6.37 (d, 11), 3.94 (s, 3H), 3.93 (s, 3H), 3.50 (s, 2H), 3.44 (br., 4H), 2.20 (br., 4H), 1.48 (d, 4H). [0410] 'N-(4-f [6,7-Bis(methyloxy)uinolin-4-ylloxvIphenyl)-N'-[3-(pipriin-1 vlmethyl)phenyllcycloproane-1,1-dicarboxamide. 1H NMR (DMSO-d6): 10.0-10.2 (br., 2H), 8.46 (d, 111), 7.76 (d,'2H), 7.53 (m, 3H), 7.39 (s, 1M), 7.24 (m, 3H), 6.98 (d, 1H), 6.43 (d, 1H), 3.95 (s, 3H), 3.93 (s, 31), 3.37 (s, 2H), 2.31 (br., 4H), 1.48 (m, 8H), 1.39 (br., 2H). [0411] 'N-(4-f6,7-Bis(methyloxy)guinolin-4-vlloxvlphenyl)-N'-3-(prrolidin-1 ylmethyl)phenyllcyclopropane-1,1-dicarboxamide. IH NMR (DMSO-d6): 10.0-10.2 (br., 2H), 8.46 (d, 11), 7.77 (d, 2H), 7.59 (s, 1H), 7.53 (d, 1H1), 7.51 (s, 1H), 7.39 (s, 1H), 7.23 (m, 3H), 6.99 (d, 1H), 6.43 (d, 11), 3.95 (s, 311), 3.93 (s, 3H), 3.52 (s, 2H), 2.42 (br., 4H), 1.69 (br, 4H), 1.48 (s, 411). Example 75 IS 0 "s 0 OH

NH

2 S, EtOK N 5 0 s+N lux 2000 s 2h 10mn

H

2 N F OH O NF NNO 1. Cs2COS, DMF , O +2, a Ammonium format, O z N S NS F Fe, ToVH 2 0 reflux 0 N 2 235 WO 2005/030140 PCTUS2004031523 H2N F FF NI N ONF HATU, TEA O AF N + 'N +FH NDMF T [0412] Synthesis of N-(4-{ r6,7-bis(methyloxy)-2-methylthio)iolin-4-ylloxy}-3 fluorophenvl-)M-(4-fluorophenyl)cyclopropane-1-dicarboxamide Commercially available 5-(bis-methylsulfanyl-methylene)-2,2-dimethyl-[1,3]dioxane-4,6-dione (3.5 g, 14 mrnol) and 3,4-dimethoxyoaniline (2.2 g 14 mmol) were reflux in EtOH (20 mL) for 2 hours. The EtOH was removed under reduced pressure and EtOAc was added to the residue. The product was filtered and washed with cold EtOAc (3X). 5-[(3,4-dimethoxy phenylamino)-methylsulfanyl-methylene]-2,2-dimethyl-[1,3)dioxane-4,6-dione was obtained as a white solid (1.7 g, 47% yield) and used without further purification. LCMS: m/z 352 (M-H. (0413] A mixture of 5-[(3,4-dimethoxy-phenylamino)-methylsulfanyl-methylene]-2,2 dimethyl-[1,3]dioxane-4,6-dione (1.7 g, 6.6 mmol) and diphenylether (3.5 g, 21 mmol) were heated at 260 0C for 10 minutes. The mixture was cooled to room temperature and heptane was added. 6,7-Dimethoxy-2-methylsulfanyl-quinolin-4-ol was filtered and isolated as an orange solid and used without further purification (1.4 g, 83% yield). LCMS: m/z 352 (M+BWt [0414] A mixture of 6,7-dimethoxy-2-maethylsulfanyl-quinolin-4-ol (1.0 g, 4.0 mmol), 3,4 difluoronitrobenzene (0.48 mL, 4.3 mmol), cesium carbonate (2.6 g, 8.0 mmol), and DMF (15 mL) was stirred at room temperature for 12 hours, after which time, the mixture was filtered. The filtrate was extracted with DCM, washed with 10% LiClyq.), water, (1X) and brine (IX), followed by drying over Na 2

SO

4 and concentration in vacuo. The crude solids were purified by flash chromatography (silica gel, 5% MeOH in DCM), affording the nitroquinoline (1.3 g, 85.8% yield) as an orange solid. LCMS: m/z 391 (M+H). A mixture of nitroquinoline (0.33 g, 0.85 mmol), 5% Pt/S on carbon (0.050 g), ammonium formate (0.40 g, 6.3 mmol) in EtOH (5 mL) was heated at 80 0 C for 1 hour The mixture was cooled to room temperature and the solvent removed under reduced pressure. The residue was dissolved in DCM, the mixture filtered, and the precipitate discarded. Removal of the organic solvent afforded 4-(6,7-dimethoxy-2-methylsulfanyl-quinolin-4 yloxy)-3-fluoro-phenylamine as an orange oil (220 mg, 73% yield). LCMS: m/z 361

(M+H)

4 . 236 WO 2005/030140 PCT/US2004/031523 [0415] To a mixture of 4-(6,7-dimethoxy-2-methylsulfanyl-quinolin-4-yloxy)-3-fluoro phenylamine (0.22 g, 0.61 mmol) and 1-(4-Fluoro-phenylcarbamoyl) cyclopropanecarboxylic acid (0.16 g, 0.73 mmol) in DMF (5 mL) was added TEA (0.25 mL, 1.8 mmol) followed by HATU (0.57 g, 1.5 mmol). The resulting solution was stirred overnight at room temperature. The reaction mixture was dumped into water and extracted with DCM (2X). The combined extracts were washed with 5% LiCiaq.) (3X), water, (iX) and brine (1X), followed by drying over Na 2

SO

4 and concentration in vacuo. The crude solids were purified by preparatory HPLC with ammonium acetate, affording N-(4-{[6,7-bis(methyloxy)-2-(methylthio)quinolin-4-yl]oxy}-3-fluorophenyl)-N(4 fluorophenyl)cyclopropane-1,1-dicarboxamide (0.39 g, 11% yield) as a white solid. 'H NMR (DMS-4) 8 10.34 (s, 1H), 9.94 (s, 1H), 7.83 (d, 1H), 7.59 (M, 21), 7.56 (m, 1H), 7.40 (m. 2H), 7.23 (s, 1M), 7.09 (t, 2H), 6.12 (s, 1H), 3.88 (s, 311), 3.85 (s, 3H), 2.48 (s, 311), 1.40 (m, 4H). Example 76 0 S NH40H, HgC12I HZ Php 0 THF H260"O,0,80mIn r ~ Qiy~C NAo~ ~ 2NH2 1. F Noa HaN F Os2CO 3 DMF 0 HATU, TEA, DMF 2. Ammonium formate, RT Fe, ToVH2 Orefux

NH

2 H 2 N N [04161 Synthesis of N-(4-([2-amino-6,7-bis(methyloxyquinolin-4-lloxyl -3 fluorophenvl)-N'(4-fluorophenvl)cyclopropane-1.1-dicarboxamide. A mixture of 5-[(3,4 dimethoxy-phenylamino)-methylsulfanyl-methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione (1.0 g, 2.8 mmol), 30% ammonium hydroxide (8.5 mL), HgCl 2 (0.76 g, 2.8 mmol) in THF (5 mL) was stirred at room temperature for 30 minutes. The mixture was extracted with DCM and water (3X) and dried with Na 2 SO4. Concentration in vacuo afforded 5-[aniino (3,4-dimethoxy-phenylamino)-methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione as a white solid (0.90 g, 97% yield) and this compound was used without further purification. LCMS: in/z 321 (M-1). 237 WO 2005/030140 PCT/US2004/031523 [0417] A mixture of 5-[amino-(3,4-dimethoxy-phenylamino)-methylene]-2,2-dimethyl [1,3]dioxane-4,6-dione (0.90 g, 2.8 mmol) and diphenylether (3.0 g, 18 mmol) was heated at 260 0 C for 30 minutes. The mixture was cooled to room temperature and heptane was added. Product 2-ainino-6,7-dimethoxy-quinolin-4-oI was filtered and isolated as an orange solid and used without further purification (0.31 g, 33% yield). LCMS: m/z 221 (M+H)*. [0418] 4-(4-Amino-2-fluoro-phenoxy)-6,7-dimethoxy-quinolin-2-ylandne was synthesized from 2-amino-6,7-dimethoxy-quinolin-4-o1 in a similar manner as 4-(6,7 dimethoxy-2-methylsulfanyl-quinolin-4-yloxy)-3-fluoro-phenylamine, and obtained as a white solid (4.0% yield). LCMS: mfz 330 (M+1)t. [0419] N-(4-{ [2-amino-6,7-bis(methyloxy)quinolin-4-yl]oxy}-3-fluorophenyl)-N'-(4 fluorophenyl)cyclopropane-1,1-dicarboxamide was synthesized from 4-(4-amino-2-fluoro phenoxy)-6,7-dimethoxy-quinolin-2-ylamine in a similar manner as N-(4-{ [6,7 bis(methyloxy)-2-(methylthio)quinolin-4-yl]oxy}-3-fluorophenyl)-N'-(4 fluorophenyl)cyclopropane-1,1-dicarboxamide. It was purified by preparatory HPLC using ammonium acetate and isolated as a white solid (4.0% yield). 1 H NMR (DMSO-d6) 8 10.34 (s, 1H), 9.95 (s, 1H), 7.82 (d, 1H), 7.58 (m, 2H), 7.44 (d, 1H), 7.33 (t, 1H), 7.25 (s, 1H), 7.09 (t, 2H), 7.07 (s, 1H), 6.17 (br s, 2H), 5.66 (s, 1H), 3.79 (s, 3H), 3.77 (s, 3H), 1.40 (d, 4H). LCMS: m/z 535 (M+H). Example 77 0h 2 O OH MeNH 2 , HgCi 280 c is i n H H HATU, TEA, DMF 00F 2. Ammonium formate, or N Fe, ToI/H 2 O reflux N 0 .%Ce [0420] Synthesis of 'N-(3-fluo-4-{[2-(methylamino)-6,7-bis(methyloxy)guinolin-4 ylloxy~phenyl)-N'-(4-fluorophenyl)cyclopropane-11-dicarboxamide. A mixture of 5 238 WO 2005/030140 PCT/US2004/031523 [(3,4-dimethoxy-phenylamino)-methylsulfanyl-methyene}.2,2-dimethyl-[1,3]ioxane4,6 dione (0.50 g, 1.4 mmol), methylamine (2 M in THF, 0.75 mL. 1.5 mmol), HgC2 (0.38 g, 1.4 mmol) in THF (5 mL) was stirred at room temperature for 30 minutes. The mixture was extracted with DCM and water (3X) and dried with Na 2 SO4. Concentration in vacuo afforded 5-[(3,4-dimethoxy-phenylamino)-methylamino-methyene]-2,2-dimethyl [1,3]dioxane4,6-dione as a yellow solid (0.48 g, 99% yield) and this compound was used without further purification. LCMS: m/z 335 (M-H). [0421] A mixture of 5-[(3,4-dimethoxy-phenylamino)-methylamino--methylene]-2,2 dimethyl-[1,3]dioxane-4,6-dione (0.40 g, 2.8 mmol) and diphenylether (3.0 g, 18 mmol) was heated at 260 0 C for 15 minutes. The mixture was cooled to room temperature and heptane was added. Product 6,7-dimethoky-2-methylamino-quinolin-4-ol was filtered and isolated as a tan solid and used without further purification (0.30 g, quantitative yield). LCMS: m/z 235 (M+H). (0422] [4-(4-Amino-2-fluoro-phenoxy)-6,7-dimethoxy-quinolin-2-yl]-methyl-amine was synthesized from 6,7-dimethoxy-2-methylamino-quinolin-4-o in a similar manner as 4-(4 Amino-2-fluoro-phenoxy)-6,7-dimethoxy-quinolin-2-ylamine, and isolated as a yellow oil (58% yield). LCMS: In/z 330 (M+H)t [0423] 'N-(3-fluoro-4-{[2-(methylamino)-6,7-bis(methyloxy)quinolin-4-yljoxy}phenyl) N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide was synthesized from [4-(4-amino-2 fluoro-phenoxy)-6,7-dimethoxy-quinolin-2-yl]-methyl-amine in a similar manner as N-(4 { [6,7-bis(methyloxy)-2-(methylthio)quinolin-4-yl]oxy}-3-fluorophenyl)-N(4-fluoro phenyl)cyclopropane-1,1-dicarboxamide. It was purified by preparatory HPLC using ammonium acetate and isolated as a white solid (6.0 mg, 4.0% yield). 'H NMR (DMSO d) 5 10.42 (s, 1H), 9.91 (s, IH), 7.88 (dd, 1H), 7.56 (in, 2H), 7.44 (m, 4H), 7.09 (t, 2H), 5.90 (s, 1H), 3.88 (a, 311), 3.85 (s, 311), 3.39 (br s, 1H), 2.92 (s, 3H), 1.41 (dt, 4H). LCMS: m/z 535 (M+H). Example 78 O FH FO O OH 00 PPh, DIAD, DCM, RT N ' 9 239 WO 2005/030140 PCT/US2004/031523 [0424] 'N-(4-f [6-{f3-(diethylamino~provlloxyl-7-(methyloxylguinolin4-Iloxy}-3 fluoropheny)-N-(4-fluorophenvflcvclopropane-1,1-dicarboxamide. To a slurry of cyclopropane-1,1-dicarboxylic acid [3-fluoro-4-(6-hydroxy-7-methoxy-quinolin-4-yloxy) phenyl]-amide (4-fluoro-phenyl)-amide (0.12 g, 0.23 nmol), hydroxypropyldiethylamine (0.090 mL, 0.61 mmol), triphenylphosphine (0.20 g, 0.76 mmol) in DCM (10 mL) was added DIAD (0.17 mL, 0.86 mmol). The resulting mixture was stirred at room temperature for 12 hours, after which time, the solvent was removed under reduced pressure. The residue was extracted with EtOAc and IN HC] (6) and brine (1X) followed by drying with Na 2

SO

4 . Concentration of the organic fraction in vacuo afforded 'N-(4-{[6-{[3-(diethylamino)propylloxy)-7-(methyloxy)quinolin-4-ylloxy}-3 fluorophenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide as a yellow oil (0.18 g, wet, ca 95% purity by analytical HPLC). Further purification by preparatory HPLC using ammonium acetate afforded the product in 99% purity by analytical HPLC. LCMS: m/z 619 (M+H). 'H NMR (DMSOd 6 ) 8 10.37 (br s, 1M), 10.00 (s, 1H), 8.44 (d, 1H), 7.87 (d, 1H), 7.62 (m, 2H), 7.49 (m, 2H), 7.41 (m, 2H), 7.13 (t, 2H), 6.40 (d, 1H), 4.17 (t, 2), 3.93 (s, 3H), 2.59 (t, 21), 2.49 (in, 61), 1.91 (m, 411), 0.94 (t, 611). Example 79 0 0O SO M e 0 O0 H e pta n e N O M a N H 4 A c i M e Cr1 O HO NH2N 0O NH 2 NMe POCISC1 1 H N N0 2 01c

NH

2 O N Me 2) Pt/S, NH 4 0COH NO N Me H H HO N FO N O O N F-z 0 N,' Me 240 WO 2005/030140 PCT/US2004/031523 [0425] '-( 4 -fluorophenvl-N'-(4-f12-methyl-6.7-bis(methylox)qguinazolin-4 lloxvlphenl)cyloMropane-1,1-dicarboxamide. Commercially available 2-amino- 4

,

5 dimethoxy-benzoic acid methyl ester (3g, 0.014 mol) and acetic anhydride (4.03 ML, 0.0426 mol) were heated in heptane at 100"C for 3 hours. After removal of heptane in vaccuo, the crude product of 2-acetylamino.4,5-dimethoxy-benzoic acid methyl ester was obtained and used without further purification. LCIMS: m/z 254 (M+I). [0426] To the crude 2-acetylamino-4,5-dimethoxy-benzoic acid methyl ester obtained above was added ammonium acetate (7.98g, 0.104 mol) and acetic acid (10 mL). The mixture was heated at reflux in a pressure tube until the formation of the desired cyclization product, as indicated by LC/MS: m/z 221 (M+H). After cooling to RT, the reaction mixture was diluted with water, and extracted with EtOAc 3 times. The combined organic phase was basified with aq. NaOH solution, and washed 3 times with EtOAc. The aqueous layer was then acidified with aq. HCl and extracted three times with EtOAc. The combined organic extract was dired over Na 2

SO

4 and concentrated in vacuo, affording 6,7-dimethoxy-2-methyl-quinazolin-4-ol (0.15g), which was used without further purification. LC/MS: m/z 221 (M+Hl). [0427] A mixture of 6,7-dimethoxy-2-methyl-quinazolin-4-ol obtained from previous step (0.15g, 0.68 mmol) and POC3 (1.59 mL, 17.04 mmol) was heated at reflux for 48 hours. The reaction mixture was poured into ice water, neutralized with NaHCO 3 , and adjusted to basic with K 2

CO

3 . The mixture was cooled to D"C with stirring. The resulting precipitate was filtered, giving 4-chloro-6,7-dimethoxy-2-methyl-quinazoline (0.094g), which was used without further purification. [0428] A mixture of the chloro quinazoline (0.094g, 0.397 mmol) obtained above, 4 nitrophenol (0.11g, 0.795 mmol) and bromobenzene (3mL) was heated at 160"C for 48 hours. The solvent was then removed and the reaction was taken up in MeOH. EtzO was added and the reaction stirred 30 min and the precipitate was filtered, affording 6,7 dimethoxy-2-methyl4-(4-nitro-phenoxy)-quinazoline (0.081g) as a very light yellow solid. LC/MS: m/z 342 (M+H). [04291 A mixture of 6,7-dimethoxy-2-methyl-4-(4-nitro-phenoxy)-quinazoline (0.081g, 0.236 mmole), Pt/S (0.008g, 15 mol%), ammounium formate (0.098g, 1.56 nunol) and EtOH (3mL) was heated with stirring at 70"C for 3 hours. The reaction mixture was then filtered while hot and washed with hot BtOH. The crude product of 4-(6,7-dimethoxy-2 241 WO 2005/030140 PCT/US2004/031523 methyl-quinazolin-4-yloxy)-phenylamine (0.924g) was obtained as a yellow solid, which was used in the next reaction without further purification. LC/MS: m/z 312 (M+H). [0430] To a mixture of 4-(6,7-dimethoxy-2-methyl-quinazolin-4-yloxy)-phonylamine (0.100, 0.321 mmol) and 1-(4-fluoro-phenylcarbamoyl)-cyclopropanecarboxylic acid (0.

0 56g, 0.386 mmol) in DMF was added DIEA (0.168 mL, 0.963 mmol), followed by HATU (0.183g, 0.482 mmol). The reaction mixture was stirred at RT for 15 hours. The mixture was diluted with EtOAc, washed with 5% LiCi aq solution three times, dried over Na2SO4, and concentrated ih vacuo. The crude product was purified on preparative BPLC to give 'N-(4-fluorophenyl)-N'-(4-{ [2-methyl-6,7-bis(methyloxy)quinazolin- 4 yljoxy}phenyl)cyclopropane-1,1-dicarboxamide (3.2 mg) as a white solid. 1H NMR (DMSO-d6) 10.15 (bs, 1H), 10.01 (bs, 1), 7.69-7.75 (m, 2H), 7.61-7.68 (m, 2H), 7.52 (s, 1), 7.32 (s, 1H), 7.23-7.29 (m, 2H), 7.12-7.19 (m, 2H), 3.93 (d, 6H), 2.43 (s, 3H), 1.53 (s, 4H). Example 80 MeO OH + H 2 N F b O LIOH'HO NF THF-H20 HO ThH1 S H [0431] PrEWaration of 1-(4-Fluoro-henylcarbamoyl)-2-methyl-cyclopropanecarboxylic acid 2-Methylcyclopropane-1,1-dicarboxylic acid methyl ester was prepared by following the literature procedure (Baldwin, J. B.; Adlington, R. M.; Rawlings, B. J. Tetrahedron Lett. 1985, 481.) The carboxylic acid (700 mg, 4.4 mmol) was dissolved in

CH

2 C1 2 (10 mL). To the resulting solution was added 4-fluoroaniline (590 mg, 5.3 mmol), HOBt (890 mg, 6.6 mmol) and EDCI (2.5 g, 13.2 mmol). The stirring was continued for 3 h At rt. CHC1 2 (30 mL) was added to the reaction mixture, and the resulting solution was washed with brine, and dried over Na 2

SO

4 . CH 2 C1 2 was removed under reduced pressure. Further purification by column chromatography gave 635 mg (57%) of the desired amide. 242 WO 2005/030140 PCT/US2004/031523 [0432] The methyl ester obtained above was then treated with UOH-H 2 0 (116 mg, 2.78 mmol, 1.1 eqiv.) in THF (2 mL) and H20 (1 mL) for 3h at rt. THF was removed under reduced pressure. The aqueous solution was diluted with 20 mL of H20, washed with ether (10 mL), and acidified with 1 N HCL The solid was filtered, dissolved in BtOAc, and dried over Na 2 SO4. Removal of BtOAc gave the crude product of 1-(4-fluoro phenylcarbamoyl)-2-methyl-cyclopropane-carboxylic acid, which was used in the next reaction. 1H NMR (400 MHz, DMSO-dr) 8 12.99 (br s, 111), 10.33 (br s, 1 H), 7.59 (dd, J = 9.0, 5.0 Hz, 2 H), 7.11 (dd, J= 9.0, 9.0 Hz, 2 H), 1.86-1.78 (m, 1 H), 1.43 (dd, J= 9.0, 4.2 Hz, I H), 1.30 (dd, J=7.8, 4.3 Hz, 1 H), 1.19 (d, J=6.3 z, 3 H). Example 81 - HO F 0 O ______e_____OMe OML ja ,El 10% Pd/C N Bn PyBOP, DiEA, CH2CL 2 N 'Bn1 F O NOF Me K2CO , DMF OMe N OH N [0433] Synthesis of (1S,2R)-N-[3-fluoro-4-({6-(methyloxy)-7-[(3-morpholin-4-ylpropyl) oxy]quinclin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)-2-mrethylcyclopropane-1,1 dicarboxamide. To a solution of 4-(7-benzyloxy-6-methoxy-quinolin-4-yloxy)-3-fluoro phenylamine (150 mg, 0.38 mmol) in CH2Cl2 (3 mL) was added DIEA (341 mg, 2.64 mmol), 1-(4-fluoro-phenylcarbamoyl)-2-methyl-cyclopropanecarboxylic acid (120 mug, 0.49 mmol) and PyBOP (686 mg, 1.32 mmol). The reaction mixture was stirred at rt for 6 I. After standard workup, the crude product was purified by column chromatography. [0434] The coupling product (130 mg, 0.21 mmol) obtained above was dissolved in BtOH (2 mL). 1,4-cyclohexadiene (170 mg, 2.1 mmol) and 10% Pd/C (10 mg) were added. The 243 WO 2005/030140 PCT/US2004/031523 mixture was stirred for 2 h under reflux. After cooling, the mixture was filtered through Celite, and washed with MeOH. Removal of the solvents gave the crude product (136 mg), which was used in the next reaction. [0435] To a solution of the 7-hydroxyquinoline (136 mg, 0.26 mmol) in DMF (2 mL) was added 4-(3-chloropropyl)morpholine hydrochloride (70 mg, 0.35 mmol) and K2C03 (69 mg, 0.50 mmol). The reaction mixture was then stirred at 80 " for 5 h. After cooling, EtOAc (20 mL) was added. The EtOAc solution was washed twice with brine, and dried over Na 2

SO

4 . Removal of EtOAc and purification by column chromatography (CH2012: MeOH = 10:1) gave '(1S,2R)-N-[3-fluoro-4-({6-(methyloxy)-7-[(3-morpholin-4 ylpropyl)oxy]quinolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)-2-methylcyclopropane-1,1 dicarboxamide. The product was then dissolved in ethyl ether, and treated with 1.5 equiv. of 1 N HCl/ether. Filtration and lyophilization gave the HC salt of '(1S,2R)-N-[3-fluoro 4-({6-(methyloxy)-7-[(3-morpholin-4-ylproliyl)oxy]quinolin-4-yl}oxy)phonyl]-N'-(4 fluorophenyl)-2-methylcyclopropane-1,1-dicarboxamide: 'H NMVR (400 MHz, DMSO-d6) 3 10.49 (br s, 1 H), 10.26 (br s, I H), 10.15 (br s, IH), 8.74 (br s, 11 ), 7.95 (br d, J=113.2 Hz, 1 H), 7.8-7.5 (m, 6 11), 7.16 (t, J= 8.9 Hz, 2 11), 6.82 (br s, 1 H), 4.34 (t, J= 5.9 Hz, 2 I), 4.02 (s, 3 H), 3.99 (br s, 2 H), 3,77 (br t, J= 12.0 Hz, 2 1), 3.56-3.30 (m, 4 H), 3.17 3.07 (m, 2 11), 2A0-2.30 (m, 2 H), 2.04-1.95 (m, 1 H), 1.45 (dd, J = 7.2, 4.7 Hz, 1 H), 1.36 (dd, J=8.5, 4.5 Hz, 11), 1.09 (d, J=6.2 Hz, 3 1). Example 82 F NH MeO OH OM 1. LUOH, THF-H 2 0 OMe Bn EDCI, HOBt OA B H2N F PyBOP, DIEA, DMF F 0" d Et O 4 10% PdlCMOH ci F N COB N N~a " N% 244 WO 2005/030140 PCTUS2004/031523 [0436] Synthesis of (1R,2R)-N-3-fluoro-4-16-(methyloxy)-7-[(3-morphlin-4-: ylpropyl)oxvl-uinolin-v lloxyphenvl-N'4-Wfluoropheny)-2-methylcycloropane-1 -1 dicarboxamide. To a solution of 4-(7-benzyloxy-6-methoxy-quinolin-4-yloxy)-3-fluoro phenylamine (322 mg, 0.82 mmol) and 2-Methyl-cyclopropane-I,1-dicarboxylic acid methyl ester (195 mg, 1.23 mmol) in CH 2 C1 2 (4 mL) was added HOBt (61 mg, 0.32 mmol) and BDCI (211 mg, 1.64 mmol). The stirring was continued for 12 h at rt. The reaction mixture was then diluted with EtOAc and washed with brine. Removal of organic solvents in vacuo and further purification by column chromatography gave the desired coupling product (153 mg). (0437] The product (153 mg, 0.29 nmol) obtained above was treated with IOH.HO (15 mg, 0.35 mmol) in THF (1 mL) and H20 (1 mL) for 2 h. THF was removed. 10 mL of H20 was added to the mixture. The aqueous solution was washed with ether, and acidified with I N HCL. The solid was then filtered and dried under vacuum. [0438] The crude carboxylic acid (118 mg, 0.23 mmol) and 4-fluoroaniline (111 mg, 0.27 mmol) weke dissolved in DMF (2 mL). To this solution was added DIEA (178 mg, 1.38 mmol) and PyBOP (358 mg, 0.69 mmol). The mixture was stirred overnight at t. It was then diluted with EtOAc, washed twice with brine. Removal of EtOAc and column chromatography gave the desired product. [0439] The product (66 mg, 0.11 mmol) obtained above was dissolved in EtOH (2 nL). 1,4-cyclohexadiene (80 mg, 1.1 mmol) and 10% Pd/C (10 mg) were added. The mixture was stirred for 2 h under flux. After cooling, the mixture was filtered through Ceite, and washed with MeOH. Removal of the solvents gave the crude product (70 mg), which was used in the next reaction. [0440] To a solution of the 7-hydroxyquinoline (80 mg, 0.15 minmol) in DMF (2 mL) was added 4-(3-chloropropyl)morpholine hydrochloride (62 mg, 0.31 mmol) and K2C03 (64 mg, 0.46 mmol). The reaction mixture was then stirred at 80 "C for 5 h. After cooling, EtOAc (20 mL) was added. The BtOAc solution was washed twice with brine, and dried over Na 2

SO

4 . Removal of EtOAc and purification by column chromatography (CH201 2 : MeOH = 10:1) gave '(1R,2R)-N-[3-fluoro-4-((6-(methyIoxy)-7-[(3-morpholin-4 ylpropyl)oxy]quinolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)-2-methylcyclopropane-1, 1 dicarboxamide. The product was then dissolved in ethyl ether, and treated with 1.5 equiv. of I N HCI/ether. Filtration and lyophilization gave the HC1 salt of '(IR,2R)-N-[3-fluoro 4-({6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]quinolin4-yl}oxy)phenyl]-N'-(4 245 WO 2005/030140 PCT/US2004/031523 fluorophenyl)-2-methylcyclopropane-1,1-dicarboxamide: 'H NMR (400 VHz, DMSO-d6) 5 10.65 (br s, 1 H), 10.54 (br s, I H), 9.74 (s, 1 H), 8.75 (br s, 1 H), 8.01 (br d, J = 12.9 Hz, 1 H-), 7.80-7.50 (In, 6 H), 7.20-7.10 (m, 2 H), 6.84 (br s, 1 H), 4.34 (br t, J = 5 Hz, 2 I, 4.04 (s, 3 H), 4.05-3.95 (m, 2 H),3.77 (br t, J = 11 Hz, 2 H), 3.52 (br d, J= 12.7 Hz, 4 H), 3.12 (br q, J = 9.0 Hz, 2 H), 2.40-2.30 (m, 2 H), 2.10-1.95 (mn, 1 H), 1.40-1.30 (m, 2 H), 1.10 (d, J=6.2 Hz, 3 H). Example 83 0 0 Eto OEt NaOH, MeOH, H 2 0 8000, 5 h 0 0 H2 .HO EtO 1. LIOH, THF, H20 0 OMe OM! 2. HN- F ~ O~e HATU, DIEACH 2

C

2 BnNH 2 ~ -N O'Bn N 0 HATU, DIEA, DMF H'O' H H HN S1,4-cyclohexadiene F:c}.. N N 0 A F 10%Pd/C, EtOH 0 0 A A K200S, DMF C -MS N 'Bn HCI N [0441] Synthesis of '(2R.3R)-N-3-fluoro-4-({6-(methyloxy)-7-r(3-morpholin-4 vlpropyl)oxyl-quinolin-4-ylloxy)phenyIl-N'-(4-fluorophenyl)-2,3-dimethylcvclopropane 1,1-dicarboxamide. 2,3-trans-Dimethyl-cyclopropane-1,1-dicarboxylic acid diethyl ester was prepared by following the literature procedure. (Ohishi, I. Synthesis, 1980, 690.) To a solution of 2,3-trans-dimethyl-cyclopropane-1,l-dicarboxylic acid diethyl ester (6.75 g, 31.5 mmol) in MeOH (30 mL) was added 33 mL of 1 N NaOH aqueous solution. The mixture was stirred at 85 "C for 5 h. MeOH was removed under reduced pressure; the residue was diluted with 40 mL of H20. The aqueous solution was washed with 20 nL of 246 WO 2005/030140 PCTUS2004/031523 ether, and acidified with 1 N HCI. Filtration -and drying under vacuum gave 4.72 g 80 %) of the desired carboxylic acid. [0442] The aniline (1.08 g, 2.78 mmol) and the carboxylic acid (518 mg, 2.78 mmol) prepared above were dissolved in CH 2 Cl 2 (15 mL). HATU (2.11 g, 5.56 mmol) and DIBA (1.8 mL, 11.1 mmol) were added. The reaction mixture was stirred at rt overnight. It was then concentrated and diluted with EtOAc. The EtOAc solution was then washed with 5% NaOH and brine. Removal of EtOAc gave the crude coupling product, which was hydrolyzed to the corresponding carboxylic acid by treatment with LiOH'H 2 0 (175 rmg, 4.17 mmol) in THF (100 mL) -H20 (50 mL) at 60 "C for 10 h. [0443] The carboxylic acid (850 mg, 1.60 mnmol) and 4-fluoroaniline (355 mg, 3.20 mmol) were dissolved in DMF (8 mL). HATU (3.89 g, 3.2 mmol) and DIEA (1.1 ml, 6.4 mmol) were added. The reaction mixture was stirred at rt overnight. H20 (10 mL) was added to the reaction, and a precipitate formed. The solid was filtered, washed with aqueous sat. Na 2

CO

3 and ether. Further purification by column chromatography gave 596 mg (60%) of the desired product. Debenzylation was done by following the standard procedure. [0444] To a solution of the 7-hydroxyquinoline (261 mg, 0.49 mmol) in DMF (5 mL) was added 4-(3-chloropropyl)morpholine hydrochloride (195 mg, 0.98 mmol) and K 2

CO

3 (202 mg, 1.46 mmol). The reaction mixture was then stirred at 80 "C for 4 h. After cooling, EtOAc (20 mL) was added. The EtOAc solution was washed twice with brine, and dried over Na 2

SO

4 . Removal of EtOAc and purification by column chromatography (CH 2 C1 2 : MeOH = 10:1) gave 122 mg (37%) of '(2R,3R)-N-[3-fluoro-4-((6-(methyloxy)-7-[( 3 morpholin-4-ylpropyl)oxy]quinolin-4-yljoxy)phenyl]-N'-(4-fluorophenyl)-2,3-dimethyl cyclopropane-1,1-dicarboxamide. 'H NMR (400 MHz, CDC 3 ) 5 8.44 (d, J = 5.1 Hz, 1 H), 8.11 (br s, 1 H), 7.77-7.70 (m, 2 H), 7.53 (s, 1 H), 7.50-7.44 (m, 2 H), 7.40 (s, 1 H), 7.22 7.16 (m, 2 H), 7.06-6.98 (m, 2 H), 6.36 (br d, I = 5.1 Hz, 1 H), 4.26 (t, I = 7.0 Hz, 2 ), 4.02 (s, 3 H), 3.72 (t, J= 44 Hz, 4 H), 2.57 (t, J = 7.3 Hz, 21H), 2.50-2.42 (m, 4 H), 2.18 2.10 (m, 2 H), 1.80-1.66 (m, 2 H), 1.30-1.24 (m, 61H). 247 WO 2005/030140 PCT/US2004/031523 Example 84 Bn H H

NH

2 N N + HO OH HATU F - - N"' DIFA Ja CN 0Q Br DMF N F ST [0445] Synthesis of 'N-(4-f{6.7-bis methyloxy)quinolin-4-yl ~l henyll-N'(4 fluorophenyl)-1-(phenylmethyl)azetidine-3,3-dicarboxamide. 1-Benzyl-azetidine-3,3 dicarboxylic acid was prepared by following the literature procedure (Miller, R. A.; et a]. Syn. Comm. 2003, 33, 3347). To a solution of 4-(6,7-dimethoxy-quinolin-4-yloxy) phenylamine (4.2 mmol, 1 equiv.) and 4-fluoroaniline (4.2 mmol, 1 equiv.) in DMF (20 mL) was charged with DIEA (12.6 mmol, 3 equiv.) and a solution of 1-benzyl-azetidine 3,3-dicarboxylic acid ( 4.2 mmol, 1 equiv.) in DMF (10 mL). The reaction mixture was allowed to stir at RT and monitored by LCMS. The reaction was complete in 6 h. The reaction mixture was diluted with ethyl acetate and washed with 10% LiCi (3x), brine (3x), dried with sodium sulfate, filtered and the solvent Was reduced in vacuo. The crude product was purified by silica gel chromatography eluting with 2% of MeOH in EtOAc. The fractions containing the desired product were further purified using preparative HPLC to give N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxyjphenyl)-N'-(4-fluorophenyl)-1 (phenylmethyl)azetidine-3,3-dicarboxamide (300 mg, 12% yield) as a white solid. 'HNMNR (DMSO-d6): 10.0 (s, 1H), 9.90 (s, 1H), 8.45 (d, 1H), 7.80 (d, 2H), 7.70 (m, 2f), 7.50 (s, 1H), 7.40 (s, 11), 7.48-7.15 (m, 9H), 3.95 (s, 6H-), 3.70 (s, 4H), 3.60 (s, 2H). LCMS (POS): 607.2 (M+H). [0446] N-(4-{ [6,7-bis(methyloxy)quinolin-4-yl]oxy)phenyl)-N'-(4-fluorophenyl) azetidine-3,3-dicarboxamide. To a solution of N-(4-{[6,7-bis(methyloxy)quinolin- 4 ylloxy}phetyl)-N'-(4-fluorophenyl)-1-(phenyhnethyl)azetidine-3,3-dicarboxamide (300 mg, 0.5 mmol) in MeOH (50 mL) was charged with Pd/C (50% wet, 10% mmol, 265 mg) and acetic acid (2 mL). The reaction mixture was subjected to hydrogenolysis condition under H2 (50 psi) on a Parr Hydrogenator for 16 hr. The reaction mixture was filtered through celite and washed with MeOH. After removal of solvent in vacuo, the crude product was purified using preparative HPLC (solvent system: MeCN/H2O/NH4OAc), affording N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl) 248' WO 2005/030140 PCTUS2004/031523 azetidine-3,3-dicarboxamide (82 mg, 32% yield) as a white solid. 'HNMR (DMSO-d6): 8.46 (d, 1H), 7.84 (d, 2H), 7.70 (in, 2H), 7.50 (s, 1H), 7.40 (s, 111), 7.24 (d, 21), 7.20 (t, 21), 6.44 (d, 1H), 4.03 (s, 4H), 3.95 (s, 6H), 1.90 (s, 31, acetate salt). LCMS (POS): 517.3 (M+H). Example 85 O F OF 0 30% HCHO, NaBH(OAc) 3 0

CICH

2

CH

2 CI H NN [0447] N-{3-fluoro-4-[(6-(methyloxy)-7-{[(1-methylpiperidin-4-yl)methvlloxygquinolin 4-yl)oxyphenyll-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide. To a solution of cyclopropane-1,1-dicarboxylic acid {3-fluoro-4-[6-methoxy-7-(piperidin-4-yhmethoxy) quinolin-4-yloxy]-phenyl}-anide (4-fluoro-phenyl)-amide, TFA salt (-500 mg, 0.71 mmol) in C1CH 2

H

2 Cl (8 mL) were added 30% formaldehyde (4 mL) and NaBH(OAc)3 (752 mg, 3.55 mmol). The reaction mixture was stirred overnight It was then quenched with aqueous sat. NaHCO 3 , extracted with EtOAc. The organic phase was washed with brine and dried over Na 2

SO

4 . Drying salts were filtered, washed with EtOAc and the filtrate concentrated in vacuo to give 210mgs of crude product. The resulting residue was redissolved in EtOAc and any insoluble material filtered. To the filtrate was added 4M HCI in dioxane (200pl) and the mixture was stirred at room temperature for 1 hour. Solids were filtered, washed with EtOAc, dried under high vacuum, dissolved in 50% aqueous AcCN and lyophilized to give 'N-{3-fluoro-4-[(6-(methyloxy)-7-f[(1-methylpiperidin-4 yl)methyl]oxy}quinolin-4-yl)oxyjphenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarbox amide, HCl salt (113 mg, -25% yield). 1 HNMR (400MHz, DMSO-d6): 8 10.51 (s, 11H), 10.30 (br. s, 111), 10.04 (s, 1H), 8.80 (d, 1H), 7.99 (dd, 1M), 7.55 (m, 2H), 7.67-7.53 (m, 411), 7.16 (t, 211), 6.89 (d, 11), 4.13 (d, 2H), 4.05 (s, 31), 3.47 (mn, 21H), 3.00 (m, 2H), 2.74 (d, 3HR), 2.17 (m, 11), 2.03 (m, 2H), 1.68 (m, 2H), 1.49 (m, 4H). LC/MS Caled for [M+H] 617.3, found 617.4. Anal. HPLC (8 min gradient): 98% pure, 3.11 min. 249 WO 2005/030140 PCT/US20041031523 Example 86 0 F KgCOs 0 F <INZI OH Hi Cl U -CI [0448] (1R,2R,3S)-N-(4-{f7-{[2-(diethylamino)ethvlloxyl-6-(methyloxy)guinolin-4 ylloxyl-3-fluorophenyl)-N'-(4-fluorophenyl)-2,3-dimethylcyclopropane-1,1 dicarboxamide. 2,3-Dimethyl-cyclopropane-1,1-dicarboxylic acid [3-fluoro-4-(7-hydroxy 6-methoxy-quinolin-4-yloxy)-phenyl]-amide (4-fluoro-phenyl)-amide (210 mg, 0.39mmol), DMA (2mls), (2-chloro-ethyl)-diethyl-amine, HCa salt (73 mg, 0.42mmol) and K2COs (136 mg,. 0.98mmol) were combined and heated at 80C overnight. The reaction mixture was then diluted with H20 and sonicated. The resulting solids were filtered, washed with H20 and dried under high vacuum. The crude product was then purified by preparative HPLC using an ammonium acetate buffer system and lyophilized to give '(1R,2R,3S)-N-(4-{[7-{[2-(diethylamino)ethyl]oxy}-6-(methyloxy)quinolin-4-yl]oxy}-3 fluorophenyl)-N'-(4-fluorophenyl)-2,3-dimethylcyclopropane-1,1-dicarboxamide (39 mg, 16% yield). 1 HNMR (400MHz, DMSO-d6): 8 10.14 (s, 1H), 9.61 (s, 1H), 8.46 (d, 1H), 7.87 (dd, 1H), 7.67 (m, 2H), 7.57 (m, 111), 7.51 (s, 1H), 7.42 (s, 1H), 7.39 (m, I1), 7.15 (t, 2H), 6.41 (d, 1H), 4.20 (m, 211), 3.94 (s, 3H), 2.87 (m, 2H), 2.60 (m, 4H), 1.80 (m, 2H), 1.18 (s, 3H), 1.17 (s, 3H), 1.01 (m, 6H). Note: 0.5eq of AcOH is present by NMR. LC/MS Caled for [M+HJ+ 633.3, found 633.4. Anal. HPLC (25 min gradient): 96% pure, 18.52 min. Example 87 0 F K0200 O F Ne KNN OH N CO HCI 250 WO 2005/030140 PCT/US2004/031523 [0449] N-(4-fi[7-f[2-(diethylaminolethv1l0xv 6-(methvloxyluinazolin-4-vlloxy}-3 fluorovhenvl)-N'-(4-lurohnylY2.2-dbaethvlcycloproane-1.1-dicarboxawide. 2,2 Dimethyl-cyclopropane-1,1-dicarboxylic acid [3-fluoro-4-(7-hydroxy-6-methoxy quinazolin-4-yloxy)-phenyl]-amide (4-fluoro-phenyl)-amide (203 mg, 0.38mmol), DMA (2mals), (2-chloro-ethyl)-diethyl-amine, HCI salt (73 ing, 0.42mmol) and K 2

CO

3 (146 mg, 1.05mmol) were combined and heated at 80C overnight. The reaction mixture was then diluted with H20 and extracted with CH 2

C

2 (3x). The combined CH 2 C1 2 extractions were washed with sat'd NaHCO 3 (1x), sat'd NaC (1x), dried (Na2SO4), and concentrated in vacuo. The resulting crude product was purified by flash chromatograghy (Silica Gel 60, 100% EtOAc, followed by 10% MeOH, 1% triethylamine in EtOAc), then dissolved, in 50% aqueous AcCN and yophilized to give 'N-(4-[7-{[2-(diethylamino)ethylloxy}- 6 (methyloxy)quinazolin-4-yloxy}-3-flubrophenyl)-N'-(4-fluorophenyl)-2,2-dimethyl cyclopropane-1,1-dicarboxamide (70 mg, 29% yield). 'HNMR (400MHz, DMSO): 6 10.24 (s, 1H), 10.00 (s, 1H), 8.54 (s, [H), 7.84 (dd, 1H), 7.66 (n, 2H), 7.56 (s, 1H), 7.51 (m, 1H), 7.43 (m, 2M), 7.18 (t, 21), 4.26 (m, 2H), 3.98 (s, 31), 2.88 (m, 2H), 2.59 (in, 4H), 1.58 (m, 2W), 1.18 (s, 6H), 1.00 (t, 6H). LCIMS Caled for [M+ll 634.3, found 634.4. Anal. HPLC (25 min gradient): 94% pure, 24.08 min. Example 88

NH

2 NaOH NH-Boo Fe NH-Boc 0 2 N = HCI Boo 2 O 0 2 N HCQ 2

NH

4 HaN ONNOH N NH-Boo N N 0 H 2

NNH

2 00 HATU, DIEA - W (N 0N.I O\TFA N 0\ [0450] Synthesis of 'N-[3-(aminomethyl)phenyll-N'-(4-f(6,7-bis(methyloxy)quinolin-4 ylloxy phenvlcyclopropane-1.1-dicarboxamide. (4-Nitro-benzyl)-carbaric acid tert-butyl ester. 4-Nitro-benzylamine, ECI salt (5.19g, 27.5mmol) was dissolved in dioxane (100mis). NaOH (3.4g, 85.0mmol) in H20 (20mls) was added, followed by Boc 251 WO 2005/030140 PCT/US2004/03152 3 anhydride (7.6g, 34.8mmol). The mixture was stirred at room temperature. After 3hrs, the reaction mixture was diluted with EtOAc and washed with H20 (3x), sat'd NaC (1x), dried (Na 2 SO4), and concentrated in vacuo. The resulting residue was triturated with hexanes, the resulting solids filtered, washed with hexanes and dried under vacuum to give (4-nitro-benzyl)-carbamic acid tert-butyl ester (6.34g, 91% yield). LC/MS Caled for [M+H]+'253.1, found 197.0 (minus t-butyl). [0451] (4-Amino-benzyl)-carbamic acid tert-butyl ester. (4-Nitro-benzyl)-carbamic acid tert-butyl ester (6.34g, 25.1mmol), iron powder (6.5g, 116mmol), ammonium formate (13.0g, 206mmol), H20 (75mls), and toluene (75mls) were combined and heated to zeflux. After 3hrs the reaction mixture was allowed to cool and filtered through Celite with thorough washing with EtOAc. The filtrate was transferred to a separatory funnel and the phases separated. The organic phase was further washed with H20 (1x), sat'd NaCl (lx), dried (Na2SO 4 ), and concentrated in vacuo to give (4-amino-benzyl)-carbamic acid tert butyl ester (5.02g, 90% yield). LC/MS Caled for [M+H] 223.1, found 167.1 (minus t butyl). [0452] [3-({ 1-[4-(6,7-Dimethoxy-quinoin-4-yloxy)-phenylcarbamoyl]-cyclopropane carbonyl}-amino)-benzyl]-carbamic acid tert-butyl ester. 1-[4-(6,7-Dimethoxy-quinolin 4-yloxy)-phenylcarbamoyl]-cyclopropanecarboxylic acid (254 ng, 0.62mmol), (4-amino benzyl)-carbamic acid tert-butyl ester (164 mg, 0.74mmol), dry DMA (10mis), HATU (714 mg, 1.88mmol), and DIEA (325ml, 1.86mmol) were combined and stirred at room temperature. After 2hrs, the reaction mixture is diluted with H20 and the resulting solids are filtered, washed with H20, followed by sat'd NaHCO 3 , and dried under high vacuum to give crude [3-((1-[4-(6,7-dimethoxy-quinolin-4-yloxy)-phenylcarbamoyl] cyclopropanecarbonyl}-amino)-benzyl]-carbamic acid tert-butyl ester (301 mg, 79% yield) which was used in the next reaction without further purification. LC/MS Calcd for [M+HJ 613.3, found 613.1. [0453] N-[3-(Aminomethyl)phenyl]-N(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl) cyclopropane-1,1-dicarboxamide, TFA salt. [3-({1-[4-(6,7-Dimethoxy-quinolin- 4 yloxy)-phenylcarbamoyl]-cyclopropanecarbonyl}-anino)-benzyl]-carbamic acid tert-butyl ester (50 mg, 0.081mmol) was dissolved in 50% TFA in CH 2 C1 2 (10mls) and stirred at room temperature. After 2hrs, the reaction mixture was concentrated in vacuo and the resulting residue was triturated with EtO. The resulting solids were filtered, washed with Et 2 O and dried under high vacuum to give 'N-[3-(aminomethyl)phenyl]-N'-(4-{[6,7 252 WO 2005/030140 PCT/US2004/031523 bis(methyloxy)quinolin-4-yl]oxylphenyl)cyclopropane-1,1-dicarboxamide as the TFA salt (54 mg, 100%). 'HNMR (400MHz, DMSO-d6): 8 10.28 (s, 111), 10.19 (s, 111), 8.77 (m, 1H), 8.21 (m, 3H); 7.84 (m, 2H), 7.76 (m, 111), 7.71 (m, 111), 7.58 (m, 211), 7.38 (m, 31), 7.19 (m, 1H), 6.76 (n, 1H), 4.03 (s, 6H), 3.39 (m, 21), 1.53 (m, 411). Note: all peaks are very broad and unresolved. LCIMS Calcd for [M+H]* 513.2, found 513.4. Anal. HPLC (25 min gradient): 88% pure, 12.39 min. [0454] Table 3 contains 'H-NMR data for selected compounds of the invention. Table Entry Name 'H-NMR 1H NMR (DMSO-d6): 10.52 (s, 1H), 10.02 (s, N-[3-fluoro-4-({6-(methyloxy)- 11), 9.38 (br., 3H), 8.79 (d, 1), 7.98 (dd, 11), 7-[(3-piperazin-1- 7.74 s, IH, 7.65 (m, 3H), 7.54 (m, 2H), 7.15 1 ylpoxy)pheny]-N-4- (t, 2H), 6.86 (d, 11), 4.33 (t, 2H), 4.04 (s, 3), yljoy~penyl-N!(4- 3.17-3.50 (m, 9H), 2.27 (br., 2H), 1.79 (m, 1W), fluorophenylcyclopropane-1, 1.48 (m, 4H). Note: The peak at 89.38 includes 2 TFA equivalents. N-{3-fluoro-4-[(6-(methyloxy)- 1H NMR (DMSO-d6): 10.41 (s, 1H), 10.03 (s, 7-{[3-(4-methylpiperazin-1- 1H), 8.47 (d, 11), 7.90 (dd, 111), 7.64(m, 21), 2 yl)propylloxy}quinolin-4- 7.52 (s, 211), 7.42 (t, 1H),7.39 (s, 1H), 7.16 (t, yl)oxy]phenyl}-NL(4- 2H), 6.41 (d, 1M), 4.18 (t, 2H), 3.95 (s, 3H), fluorophenyl)cyclopropane-1,1- 2.47 (t, 21), 2.6-2.8 (br., 8H), 2.17 (s, 311), dicarboxamide 1.97 (m, 2$, 1.48 (s, 4H). N-{3-fluoro-4-[(6-(methyloxy)- 1H NMR (400MHz, DMSO-d6): d 10.51 (s, 7-{ [(1-methylpiperidin-4- 1H, 10.30 (br. s, 1), 10.04 (s, 111), 8.80 (d, yl)methyl]oxy)quinolin-4- 111), 7.99 (dd, 1H), 7.55 (m, 2H), 7.67-7.53 (in, 3 yl)oxyjphenyl}-N'-(4- 4H), 7.16 (t, 2H), 6.89 (d, 111), 4.13 (d, 211), fluorophenyl)cyclopropane-1,1- 4.05 (s, 311), 3.47 (m, 2H), 3.00 (m, 2$, 2.74 fr ecyopae- (d, 31), 2.17 (m, 11), 2.03 (in, 2H), 1.68 (M, 211), 1.49 (m, 4H). N-(4-fluorophenyl)-N'[4-(6- H NMR (400 MHz, DMSO-d6): 8.47 (d, I , (methyloxy)-7-[(3-iorpholin-4- 8.30 (m, 11), 8.15 (m, 1$), 7.8 (m, 2), 7.62 4 ylpropyl)oxy]quinolin-4- (a, 111), 7.45 (m, 21), 7.2 (m, 3H), 7.10 (m, yloxy)phenyljcyclopropane- 2H), 6.7 (d, 1$, 4.5 (m, 2H, 4.3 (m, 2R), yLx-dicarboxaraide 4.01(s, 311), 3.5 (br, 2H), 3.3 (m, 2H), 3.1 (w, 2), 2.51 (m, 2H), 1.9 (m, 2H)1.6 (m, 4H). N-(4-{ [7-{ [3- '1H NMR (400 MHz, DMSO-d6): 10.58 (s, 1H), (diethylainno)propyl]oxy}-6- 10.31 (bs, 111), 10.04 (s, 1H), 8.75 (d, 1H), 5 (methyloxy)quinolin-4-yl]oxy}- 7.99 (d, 1), 7.74 (s, 1H), 7.63 (m, 4$, 7.19 3-fluorophenyl)-N'-(4- (t, 21), 6.91 (m, 111), 4.39 (t, 2H), 4.19 (s, 3H), fluorophenyl)cyclopropane-1,1- 3.21 (m, 7H), 2.29 (m, 2H), 146 (d, 4H), 1.15 dicarboxamide (t, 61). 253 WO 20051030140 PCT/US20041031523 Table 3 Entry Name 'H-NMR N-(4-{[l6,7- 1H NMR (DMSO-d6): 11.56 (s, 1H), 9.77 (a, bis(methyoxy)uinorn-4- 1H), 8.50 (d, I), 8.32 (c 1H), 7.82 (d, 1H, 6 florophenyl)-N'-(4- 7.59 (m, 2H), 7.51 (a, 1H), 7.42 (s, 1H), 7.20 (t, flurohenl)N'-4- 211, 6.55 (ci, IM1, 3.95 (a, 3112), 3.94 (s, 3H1), fluoropheny cyclopropane-1, 1.73 (i, 21H) 3.65 (i, 2 ),. N-(4-{ (6,7-bis(methyloxy)-2- 'H NMR (DMSO-d) d 10.34 (s, 1M), 9.94 (s, (methylthio)quinolin-4-yI]oxy}- 1H), 7.83 (c, 1), 7.59 (m, 2M), 7.56 (m, 1H), 7 3-fluorophenyl)-N'-(4- 7.40 (m, 2H), 7.23 (s, 111), 7.09 (t, 211), 6.12 (s, fluorophenyl)cyclopropane-1,1- 1H), 3.88 (s, 3M), 3.85 (s, 3H), 2.48 (s, 3H), dicarboxamide 1.40 (m, 41). N-(4-fluorophenyl)-N'-(4-{[2- 'H NMR (DMSO-4) 10.15 (bs, 1R), 10.01 (bs, methyl-6,7- 1H), 7.69-7.75 (in, 2H), 7.61-7.68 (m, 21), 8 bis(methyloiy)quinazolin-4- 7.52 (s, 1ff), 7.32 (s, 1H), 7.23-7.29 (m, 21), yl]oxy}phenyl)cyclopropane- 7.12-7.19 (m, 2H), 3.93 (d, 61), 2.43 (s, 3H), 1,1-dicarboxamide 1.53 (s, 41). N-(4-{[2-amino-6,7- 1H NMR (DMSO-d6) d 10.34 (s, 1H), 9.95 (s, bis(methyloxy)quinolin-4- 1), 7.82 (d, 11), 7.58 (m, 2H), 7.44 (d, 1H), 9 yl]oxyj-3-fluorophenyl)-N'-(4- 7.33 (t, 1M), 7.25 (s, 1H), 7.09 (t, 21), 7.07 (s, fluorophenyl)cyclopropane-1,1- 1H), 6.17 (br s, 211), 5.66 (s, 111), 3.79 (s, 3H), dicarboxamide 3.77 (s, 3H), 1.40 (d, 4H). N-(3-fluoro-4-{ (2 (methylamino)-6,7- 'H NMR (DMSO-d) d 10.42 (s, 1M), 9.91 (s, 10 bis(methyloxy)quinolin-4- 11), 7.88 (dd, 1H), 7.56 (m, 2H), 7.44 (m, 4H), y1]oxy}phenyl)-N'-(4- 7.09 (t, 2H), 5.90 (s, 1H), 3.88 (s, 3H), 3.85 (s, fluorophenyl)cyclopropane-1,1- 3H), 3.39 (br s, 1H), 2.92 (s, 3H), 1.41 (dt, 4H). dicarboxamide 'H NMR (400 MHz, DMSO-d 6 ) d 10.49 (br a, (1S,2R)-N-[3-fluoro-4-({6- 1 H), 10.26 (br s, 1 H), 10.15 (br s, 11), 8.74 (inthyloxy)-7.-[(3-morpholin-4- (br s, 1 ), 7.95 (br d, J = 13.2 Hz, 1 H), 7.8 y(prmpyl)oxyquiohin-4- 7.5 (m, 6 11), 7.16 (t, J = 8.9 Hz, 2 H), 6.82 (br 11 ylpoxy)phenyl]-Ni-(4- s, 11 ), 4.34 (t, J = 5.9 Hz, 2 1), 4.02 (s, 3 ), 1luoyopeny N(- 3.99 (br s, 2 H), 3.77 (br t, J = 12.0 Hz, 2 H), athylulopropenyl) - 3.56-3.30 (m, 4 H), 3.17-3.07 (m, 2 H), 2,40 dicurboxan-ide 2.30 (m, 2 ), 2.04-1.95 (m, 1 ), 1.45 (dd, J= 7.2, 4.7 Hz, 1 H), 1.36 (dd, J= 8.5, 4.5 Hz, 1 1), 1.09 (d, J=6.2 Hz, 3 H). 254 WO 2005/030140 PCT/US2004/031523 Table 3 Entry Name 'H-NM NH NMR (400 Mz, DMSO-d 6 ) d 10.65 (br s, (IR,2R)-N-[3-fluoro4-({6- 1 11), 10.54 (br s, 1 H), 9.74 (s, I H), 8.75 (br s, (methyloxy)-7-[(3-morpholin-4- 1 H), 8.01 (br d, J = 12.9 Hz, 1 H), 7.80-7.50 ylpropyl)oxy]quinolin-4- (m, 6 H), 7.20-7.10 (in 2 H), 6.84 (br s, 1 H), 12 yl}oxy)phenyl]-N'-(4- 4.34 (br t, J=5 Hz, 2 H), 4.04 (s, 3 H), 4.05 fluorophenyl)-2- 3.95 (m, 2 H), 3.77 (br t, J= 11 Hz, 2 H), 3.52 nethylcyclopropane-1,1- (br d, J=12.7 Hz, 4 H), 3.12 (br q, J= 9.0 Hz, dicarboxamide 2 H), 2.40-2.30 (m,, 2 11),'2.10-1.95 (m, I H), 1.40-1.30 (m, 2 H), 1.10 (d, IJ=6.2 Hz, 3 H). N-(4-{f[6{[3- 1 H NMR (DMSO-d 6 ) d 10.37 (br s, 1H), 10.00 (diethylamino)propyl]oxy}-7- (s, 1), 8.44 (d, 1H), 7.87 (d, 1H), 7.62 (m, 13 (methyloxy)quinoln-4-y]oxy}- 2H), 7.49 (m, 2H), 7.41 (m, 2H), 7.13 (t, 2H), 3 1 1 6.40 (d, 11), 4.17 (t, 2H), 3.93 (s, 3H), 2.59 (t, fluorophylcyclrb pane-1,1- 21), 2.49 (nm, 6H), 1.91 (m, 4H), 0.94 (t, 6H). N-(4-{[6-{[2- 'H NMR (DMSO-d 6 ) d 10.36 (br s, 1H), 9.99 (diethylamino)ethyl]oxy}-7- (s, 1Hi), 8.44 (d, 1H), 7.88 (dd, 1H), 7.62 (m, 14 (2Hthy)oxy)quinolin-4-ylloxy}- 21D, 7.57 (m, 2H), 7.41 (m, 2H), 7.13 (t, 2H), 3-fluorophenyl)-W-(4- 6.40 (d, 1H), 4.17 (t, 21), 3.93 (s, 3H), 2.85 (t, fluorophenyl)cyclopropane-1,1- 2H), 2.56 (q, 4) 2.49 (m, 4H), 0.98 (t, 6H). dicarboxainide 21,25 1,1-dimethylethyl 4-(3-([4-[(2- 1H NMR (400 MHz, CDC 3 ): 10.05 (s, 1H), fluoro-4f-{ [(1-{ [(4- 8.49-8.27 (t, 11), 7.79-7.76 (d, 1H), 7.57 (s, fluorophenyl)amino]carbonyflc 1H), 7.47-7.43 (m, 3H), 7.27-7.20 (m, 1H), 15 yclopropyl)carbonyl]amino}phe 7.09-7.04 (m, 2H), 6.40-6.39 (d, 1H), 4.28-4.25 nyl)oxy]-6- (t, 2H), 3.50 (s, 311), 3.47-3.44, (t, 4H), 2.62 (methyloxy)quinolin-7- 2.59 (t, 2H), 2.46-2.44 (t, 4H), 2.18-2.11 (m, yl]oxyjpropyl)piperazine-1- 2H), 2.09 (s, 1K), 1.83-1.81 (t, 2H), 1.64-1.61 carboxylate (t, 2H), 1.47 (s, 9H). (1R,2R)-N-[3-fluoro-4-({6- 11 (Iethyloxy)-7-[(3-morpholin-4- H NMR (DMSO-do) d 10.40 (s, 1H), 9.65 (s, ylpropyl)oxyquinazolin-4- 1H), 8.45 (s, 11), 7.79 (dd, 1H), 7.53 (m, 211), 16 y1Ioxy)pheny]-N'-(4- 7.47 (s, 1H), 7.36 (m, 1H), 7.31 (m, 2H), 7.05 floropheny-2- (t, 211), 4.17 (t, 21), 3.91 (s, 3H), 3.51 (t, 41), tluorophenyl)-2- 2.40 (t, 21, 2.36 (i, 4H), 1.90 (m, 3H), 1.30 methylcyclopropane-1,1- (mn, 2H1), 1.02 (di, 31-). dicarboxamnie (1R,2R)-N-(4-{ [7-{[2- 1 H NMR (DMSO-d) d 10.49 (s, 1H), 9.73 (s, (diethylamino)ethyloxy)-6- 1K), 8.52 (s, 1H), 7.85 (dd, 1H), 7.61 (m, 2H), 17 y moxy}-3-fluorophenyl)-N'-(4- 7.54 (s, 1H), 7.41 (m, 311), 7.12 (t, 2H), 7.23 (t, fluorophenyl)-2- 2H), 3.96 (s, 31), 2.86 (t, 2H), 2.56 (q, 4H), methylcyclopropane-1,1- 1.98 (m, 11), 1.34 (m, 211), 1.07 (d, 3H), 0.97 dicarboxamnide (t, 61. 255 WO 20051030140 PCT/US2004/031523 Table 3 Entry Name N-(4-{[7-{y[3- 1H NMR (DMSO-d6) 8.51 (s, 111), 7.78-7.84 (diethylno)propoxy-6- (m, 111), 7.58-7.64 (m, 2H), 7.53 (s, 1H), 7.34 18 yoxy}-3-fluorophenyl)-N'-(4- 7.48 (m, 3H), 7.13 (t, 2H), 4.22 (t, 2H), 3.98 (s, fluorophenyl)cyclopropane-1, 1- , 2.84 (t, 2H), 2.55 (q, 4H), 1.48 (s, 4H), dicarboxamide 1.39 (t, 6H). H NMR (400 lHz, CDC 3 ): 10.04 (s, 1), N-(4-{[7-{[3-(4-acetylpiperazin- 8.48-8.47 (d, 1H), 8.21 (s, 1H), 7.79-7.76 (d/ 1-yl)propylloxy}-6- 1H), 7.57 (s, 1H), 7.52-7.44 (m, 3H), 7.28-7.20 19 (methyloxy)quinolin-4-yljoxy)- (m, 21), 7.09-7.05 (t, 2H), 6.40-6.39 (d, 1), 3-fluorophenyl)-N'-(4- 4.304.26 (t, 21), 4.04 (s, 3H), 3.64-3.62 (t, fluorophenyl)cyclopropane-1,1- 21), 3.49-3.47 (t, 211), 2.62-2.58 (t, 2H), 2.50 dicarboxamide 2.44 (m, 41), 2.17-2.12 (in, 2H), 2.10 (s, 3H), 1.84-1.81 (t, 21), 1.64-1.61 (t, 2H). 1,1-dimethylethyl 4-(3-{[4-[(2- 1H NMR (400 MHz, DMSO-d): 10.54 (s, 11), fluoro-4-{[((1R2R)-1-{ [(4- 9.72(s, 1H), 8.47-8.46 (d, 1K), 7.96-7.93 (dd, fluorophenyl)emino]carbonyl}- 1H), 7.63-7.61 (m, 2H), 7.52 (br s, 2H), 7.42 2- 7.40 (d, 21), 7.17-7.12 (t, 2H), 6.44-6.42 (d, 20 methylcyclopropyl)carbonylam 1H), 4.24.18 (t, 2), 3.95 (s, 3H, 3.42-3.40 ino}phenyl)oxyl-6- (m, 2H), 2.36-2.26 (m, 8H), 2.00-1.98 (m, 3H), yl](myloxy)qinorine-1- 1.58-1.54 (m, 2H), 1.40 (s, 9H), 1.10-1.09 (d, carboxylate N-(4-{[6,7 bis(methyloxy)quinolin-4- 1H NMR (DMSO-d6): 10.0 (s, 1H), 9.9 (s, 21 yl]oxy}phenyl)-N'-(4- 11), 8.45 (d, 1K), 7.8 (d, 2H), 7.7 (m, 2H), 7.5 fluorophenyl)-1- (s, 1K), 7.4 (s, 1K), 7.48-7.15 (m, 9H), 3.95 (s, (phenylmethyl)azetdine-3,3- 61), 3.7 (s, 4H), 3.6 (s, 21). dicarboxamide N-(4-{[6,7- 1H NMR (DMSO-d6): 8.46 (d, 11), 7.84 (d, bis(inetyioxy)quinolin-4- 2H), 7.70 (m, 2H), 7.50 (s, 1H), 7.40 (S, 11), fluorophenyl)azetidine-3 - 7.24 (d, 21), 7.20 (t, 2H, 6.44 (d, 1H), 4.03 (s, drboamide ' 4H), 3.95 (s, 6H), 1.90 (s, 3H, acetate salt). (1R,2S)-N-f3-fhuoro-4-[(6- IH NMR (400 MHz, DMSO-d): 10.26 (s, 1H), (methyloxy)-7-{ [3-(4- 9.75 (s, 1H, 8.47-8.46 (d, 1H), 7.91-7.87 (dd, methylpiperazin-1- 1H), 7.70-7.66 (m, 21), 7.56-7.51 (i, 2H), 23 yl)propyl]oxy)quinolin-4- 7.43-7.38 (m, 2H, 642-6.41 (d, 1K), 4.20-4.16 yl)oxyjphenyl)-N'-(4- (t, 2H), 3.95 (s, 3H), 2.47-2.43 (m, 2H), 2.40 fluorophenyl)-2- 2.24 (m, 5H), 2.14 (s, 3M), 2.03-1.93 (n, 3), methylcyclopropane-1,1- 1.89 (s, 3H), 1.45-1.42 (m, 1H), 1.38-1.35 (m, dicarboxamide 1H), 1.10-1.08 (d, 3M). 256 WO 20051030140 PCT/US2004/031523 Table 3 Entry Name 'H-NMR (1R,2R)-N-{3-fluoro-4-[(6- 'H NMR (400 M&z, DMSO-d): 10.56 (s, 1), (methyloxy)-7-{[3-(4- 9.75 (s, 1), 8.47-8.46 (d, 1H), 7.96-7.93 (d, methylpiperazin-1- 1H), 7.68-7.61 (in, 21), 7.53-7.52 (m, 2H), 24 yl)propyl]oxy}quinolin-4- 7.44-7.39 (in, 2H), 7.18-7.12 (m, 2$), 6.44 yl)oxy]phenyl)-N'-(4- 6.42 (d, 1H), 4,204.17 (t, 21), 3.95 (s, 3), fluorophenyl)-2- 3.42-3.30 (m, 3H), 2.46-2.44 (in, 2H), 2.33 (br methylcyclopropane-1,1- s, 2H), 2.15 (s, 3H), 2.05-1.94 (m, 211), 1.89 (s, dicarboxamide 15H), 1.40-1.35 (mn, 1H), 1.10-1.09 (m, 3). (1R,2R)-N-[3-fluoro-4-({6- 'H NMR (400 MHz, DMSO-d): 10.55 (s, 11i), (inethyloxy)-7-[(3-piperazin-1- 9.72 (s, 111), 8.47-8.46 (d, 1), 7.96-7.93 (d, ylpr(pyl)oxy]quinolin-4- 1, 7.68-7.61 (m, 2$), 7.52 (br s, 2H), 7.44 25 yl}oxy)phenyl]-N'-(4- 7.40 (i, 2H), 7.17-7.12 (mn, 2H), 6.44-6.43 (d, fluorophenyl)-2- 11), 4.21-4.18 (t, 2H), 3.95 (s, 3H), 2.79 (br s, 4H), 2.47-2.44 (t, 2H), 2.38 (br s, 3H), 2.04 miethycyclopropane-1,1- 1.95 (i, 3H), 1.40-1.35 (m, 2H), 1.11-1.09 (m, 5H). N-(3-fluoro-4-{[7-({3-[4-(1- 'HNMR (400 MHz, DMSO-d 6 ): 10.40 (s, 1H), 10.02 (s, 1H), 8.47-8.46 (d, 11), 7.92-7.89 (d, methylethyl)pp -1- 1H), 7.66-7.63 (m, 2H), 7.52-7.51 (d, 2H), 26 (mhyljpropxy) -6- 7.44-7.39 (m, 21), 7.19-7.14 (m, 2H), 6.42 26n(tyloxy quino- 4- 6.41 (d, 111), 4.20-4.17 (t, 2H), 3.95 (s, 311), luoxyjphenyl)yclop aNe-( - 2.70-2.68 (m, 1H), 2.62-2.55 (m, 211), 2.46 dicarboxande 2.33 (m, 8H), 1.99-1.94 (m, 2), 1.47 (s, 41, 1.00-0.95 (m, 6). N-(4-{[7-{([3- 'H NMR (DMSO-ds)10.34 (s,l1H, 10.01 (s, (diethylamino)propyl]oxy}-6- 11), 8.50 (s, 11), 7.81 (dd, 11), 7.55-7.68 (m, 27 (methyloxy)quinazolin-4- 2H), 7.51-7.55 (m, 2H), 7.33-7.48 (in, 3H), yljoxy}-3-fluorophenyl)-N'-(4- 7.12 (t, 2H), 4.22 (t, 2$), 3.94 (s, 3H), 2.52 fluorophenyl)cyclopropane-1,1- 2.61 (m, 2), 2.49-2.51 (m, 4$), 1.83-1.94 (m, dicarboxamide 2H), 1.42 (s, 4H), 0.95 (t, 6H). (1R,2R)-N-(4-{[7-{[3- 'H NMR (DMSO-d) d 10.52 (s, 1H), 9.70 (s, (diethylamino)propyl]oxy)-6- 1H), 8.44 (d, 1H), 7.92 (dd, 1$), 7.61 (m, 2), (23ethyloxy)quinolin-4-yloxy}- 7.50 (m, 2H), 7.43 (m, 2$), 7.12 (t, 2$), 6.41 28 3-fluorophenyl)-2-(4- (d, 1, 4.17 (t, 2H), 3.93 (s, 3H), 2.55 (m, eycpropan)-1- 2$), 2.31 (m, 4H), 1.98 (m, 1H), 1.88 (m, 211), methycycroane-1,1- 1.35 (m, 21), 1.07 (c 3H), 0.94 (t, 6$). (1R,2R)-N-(4-{[7-{[2- 'HNMR (DMSO-ds) d 10.52 (s, 1M), 9.70 (r, (dietbylamino)ethyl]oxy}-6 111), 8.44 (d, 1H), 7.78 (dd, 1), 7.61 (im, 2), (23ethyloxy)quinohn-4-yloxy- 7.51 (m, 2H), 7.41 (m, 2$), 7.12 (t, 2H), 6.41 29 3-fluorophnyl)-N-(4- (d, 1M, 4.17 (t, 21), 3.93 (s, 3H), 2.85 (t, 2H), fluorophenyl)-2- 2 57 (q, 41H), 1.98 (ni, 1$), 1.34 (in, 2$), 1.07 methylcyclopropane-1,1 dicarboxamide (d, 31, 0.98 (t, 61). 257 WO 2005/030140 PCTUS2004/031523 Table 3 Entry Name 1 H.NMR (1R,2S)-N-(4-{[7-{[3- IH NMR (DMSOd) d 10.17 (s, 1H), 9.97 (s, (diethylamino)propyl]oxy}-6- 1M), 8.39 (d, 1H), 7.80 (dd, 1H), 7.62 (m, 2H), (inethyloxy)quinolin-4-ylloxy}- 7.45 (m, 28), 7.31 (m, 2$, 7.09 (t, 2H), 6.34 30 3-fluorophenyl)-N'-(4- (d, 1H), 4.12 (t, 21), 3.88 (s, 3H), 2.46 (m, fluorophenyl)-2- 2H), 2.40 (in, 41), 1.92 (in, 1H), 1.84 (m, 2H), methylcyclopropane-1,1- 1.37 (m, 1H), 1.29 (m, 1H), 1.01 (d, 3H), 0.89 dicarboxamide (t, 6H). (1R,2S)-N-(4-{[7-{[2- 1 HNMR (PMSO-d) d 10.22 (s, 1H), 10.01 (s, (diethylaninothyl]oxy}-6- 11), 8.44 (d, 1H), 7.86 (dd, 1H), 7.66 (m, 28), 31 h7Z.9 (m, 21), 7.39 (mn, 2H), 7.14 (m, 2), 6.39 1-fluorophenyl).-- (d, 1H), 4.18 (m, 2H), 3.92 (s, 3H), 2.85 (t, metlycyopone-1,1- 2H), 2.57 (q, 4H), 1.97 (m, 1H), 1.42 (m, 18), 1.35 (m, 1), 1.06 (d, 3H), 0.98 (t, 6H). N-(4-{[7-1[2- '11 NMR (CDC1 3 ) 8.57 (s, 1H), 8.12 (s, 1H), (diethylmino)eiyloxy}-6- 7.73-7.81 (in, 2H), 7.48-7.53 (m, 2H), 7.32 (s, 32 '(methyloxy)quinazolin-4- 1H), 6.98-7.08 (m, 313), 4.28 (t, 2H), 4.04 (s, yl]oxy}-3-fluorophenyl)-N-(4- 3H), 3.25 (t, 21), 2.76 (q, 4H), 2.67 (q, 48), fluorophenyl)cyclobutane-1,1- 2.01-2.15 (m,2H), 1.10 (t, 6H). dicarboxamide (1R,2S)-N-[3-fluoro-4--({6- IH NMR (400 MHz, DMSO-d): -10.28 (s, 111), (mthyloxy)-7-[(3-plperazin-1- 9.80 (s, 1H) 8.47-8.46 (d, 11), 7.90-7.88 (d, y(propyl)oxy)quin pin-- 1H, 7.70-7.62 (m, 21), 7.56-7.52 (m, 2H), 7.44-7.39 (m, 2H), 7.18-7.12 (mu, 2H), 6.44 33 yl}oxy)phenyl]-N'-(4- 6.41 (t, 1H), 4.20-4.17 (t, 21), 3.95 (s, 311), laorophenyl)-2- 2.74-2.72 (t, 3H), 2.46-2.42 (m, 1H), 2.35 (br s, methyycloppane-1,1- 3H), 2.03-1.93 (M, 313), 1.87 (s, 4H), 1.43-1.35 (m, 2H), 1.09-1.08 (mn, 3H). (lr,2R,3S)-N-[3-fluoro-4-({6- 1HNMR (DMSO-d6): 1H(10.12 ppm, s), 1H (methyloxy)-7-[(3-morpholin-4- (9.6 ppm, s), 1H (8.46 ppm, d), 1H (7.88 ppm, ylpropyl)oxylquinolin-4- dd), 2H (7.68 ppm, m), 1H (7.56 ppm, d), 1H 34 yl}oxy)phenyl]-N'-(4- (7.51 ppm, a), 2H(7.4 ppm, m), 25 (7.13 ppm, fluorophenyl)-2,3- t), 1H (6.4 ppm, d), 2H (4.2 ppm, t), 3H (3.94 dimethylcyclopropane-1,1- ppm, s), 4H (3.6 ppm, t), 2H (2.45 ppm, t), 4H dicarboxamide (2.37 ppm, m), 2H (1.97 ppm, t), 2H (1.8 ppm, m), 6 H(1.28 ppm, d). (1r,2R,3S)-N-(3-fluoro-4-[(6- 1HNMR (DMSO-d6): 1H (10.12 ppm, s), 1H (methyloxy)-7-{[3-(4- (9.6 ppm, s), 18 (8.46 ppm, d), 11 (7.88 ppm, methylpiperazin-1- dd), 2H (7.69 ppm, m), 1H (7.58 ppm, d), 111 35 yl)propylloxy)quinolin-4- (7.51 ppm, s), 2H (7.4 ppm, m), 2H (7.13 ppm, yl)oxy]phenyl)N'-(4- t), 1H (6.4 ppm, d), 2H (4.2 ppm, t), 3H (3.95 fluorophenyl)-2,3- ppm, s), 10H (2.35 ppm, m), 3H (2.14 ppm, s), dimethylcyclopropane-1,1- 2H (1.97 ppm, t), 2H (1.8 ppm, m), 6H (1.28 dicarboxamide ppm, d). 258 WO 2005/030140 PCT/US2004/031523 Table 3 Entry Name 1 H-NMR N-[3-fluoro-4-({6-(methyloxy)- 'H NMR (400 MHz, DMSO-d6): 8.45 (d, 2 H), 7-[(3-morpholin-4- 8.15 (d, 111), 7.8 (d, 1H), 7.45 (m, 3H), 7.25 36 y }opyl)x nazol-N4- (m, 311), 7.0 (M, 2H), 4.20 (t, 2H), 4.0 (s, 3H), fluorophenyl)cyclobutane-1,1- 3.7 (m, 4H), 2.67 (m, 4H), 2.45 (m, 6H), 2.0 dicarboxamide (m, 41). I'H NMR (400 MHz, CDs) d 8.44 (d, J=5.1 (2R,3R)-N-[3-fluoro-4-({6- Hz, 1 H), 8.11 (br s, 1 H), 7.77-7.70 (m, 2 H), (methyloxy)-7-[(3-morpholin-4- 7.53 (s, 1 H), 7.50-7.44 (m, 2 11), 7.40 (s, 1 H), ylpropyl)oxyjquinolin-4- 7.22-7.16 (m, 2 H), 7.06-6.98 (in, 2 H), 6.36 37 yl}oxy)phenyl-N'-(4- (br d, J = 5.1 Hz, 1 11), 4.26 (t, J = 7.0 Hz, 2 H), fluorophenyl)-2,3- 4.02 (s, 3 H), 3.72 (t, J = 4.4 Hz, 4 H), 2.57 (t, J dimethylcyclopropane-1,1- = 7.3 Hz, 2 1), 2.50-2.42 (m, 4 H), 2.18-2.10 dicarboxamide (m, 2 H), 1.80-1.66 (m, 2 11), 1.30-1.24 (m, 6 H). (2R,3R)-N-(4-{[7-{[3- 1H NMR (400 MHz, DMSO-d) d 10.34 (s, 1 (diethylamino)propy1]oxy}-6- H), 10.05 (s, I H), 8.46 (br s, 1 1), 7.93 (br d, J (methyloxy)quinolin-4-yl]oxy}- = 4.7 Hz, 11 ), 7.54-7.52 (m, 2 H), 7.52-7.50 38 3-fluorophenyl)-N'-(4- (in, 2 H), 7.50-7.30 (m, 2 1), 7.20-7.10 (n, 2 fluorophenyl)-2,3- H), 6.47 (br s, 1 H), 4.30-4.20 (m, 2 H), 3.95 (s, dimethylcyclopropane-1,1- 3 H), 3.40-3.10 (m, 6 H), 2.60-2.40 (i, 2 11), dicarboxamide 1.90-1.80 (m, 2 H), 1.30-1.10 (n, 12 H). N-(4-{[7-f [3- 1H NMR (400MHz, DMSO-d6): d 10.47 (s, (diethylamino)propyl]oxy}-6- 1H), 10.16 (s, 1H), 8.43 (d, 1H), 7.92 (dd, 1H), (methyloxy)quinolin-4-yl]oxy}- 7.67 (m, 2H), 7.58 (m, 111), 7.52 (s, 1H), 7.41 39 3-fluorophenyl)-N'-(4- (m, 21), 7.15 (t, 2H), 6.44 (d, 11), 4.25 (t, 2H), fluorophenyl)-2,2- 3.95 (s, 3H), 3.10 (m, 6H), 2.17 (m, 2H), 1.91 dimethylcyclopropane-1,1- (s, 3H, acetate salt), 1.52 (n, 2H), 1.18 (m dicarboxamide 1211). N-[3-fluoro-4-({6-(methyloxy)- 1H NMR (400MHz, DMSO-d6): d 10.21 (s, 7-[(3-morpholin-4- 11), 9.97 (s, 1H), 8.51 (s, 1H), 7.81 (dd, 1H), ylpropyl)oxy)quinazolin-4- 7.64 (m, 2H), 7.54 (s, 1H), 7.48 (m, 1H), 7.41 40 yl}oxy)phenyl]-N'-(4- (m, 11), 7.38 (s, 1H), 7.15 (t, 2H), 4.24 (t, 2H), fluorophenyl)-2,2- 3.97 (s, 3M), 3.58 (m, 41), 2.45 (t, 2H), 2.38 dimethylcyclopropane-1,1- (m, 41), 1.97 (m, 2H), 1.58 (m, 2H), 1.18 (s, dicarboxamide 3H), 1.17 (s, 31). (1R,2R,3S)-N-(4-{[7-{[2- 1H NMR (400MvlHz, DMSO-d6): d 10.14 (s, (diethylamino)ethyl]oxy}-6- 1H), 9.61 (s, 11), 8.46 (d, 1), 7.87 (dd, 11), (methyloxy)quinolin-4-yI]oxy)- 7.67 (m, 2H), 7.57 (m, 111), 7.51 (s, 111), 7.42 41 3-fluorophenyl)-N'-(4- (s, 1H), 7.39 (n-, 1H), 7.15 (t, 2H), 6.41 (d, fluorophenyl)-2,3- 1), 4.20 (m, 2H), 3.94 (s, 311), 2.87 (m, 2H), dimethylyclopropane-1,1- 2.60 (m, 41), 1.80 (m, 2H), 1.18 (s, 3H), 1.17 dicarboxamide (s, 3H), 1.01 (m, 61). Note: 0.5eq of AcOH is present by NMR. 259 WO 2005/030140 PCT/US2004/031523 Table 3 Entry Name 'H-NMR (diethylaN )ehyl7oxy}-6- 11H NMR (400MHz, DMSO): d 10.24 (s, 1H), (iethyloxy)quinazolin-4- 10.00 (s, 111), 8.54 (s, 1H), 7.84 (dd, 1), 7.66 42 yloxy}-3-fluorophenyl)-N'-(4- (m, 2ff), 7.56 (s, 11), 7.51 (m, ID), 7.43 (in, fluorophenyl)-2,2- 213), 7.18 (t, 2H), 4.26 (m, 2H), 3.98 (s, 311), dimnethlyloopropane-1,1- 2.88 (, 211, 2.59 (m, 4), 1.58 (m, 2H), 1.18 dimtycroane-1 (a, 6$0, 1.00 (t, 6H). N-(4-{[7-{ [3- 1H NMR (400Mfz, DMSO-d6): d 10.21 (g, (diethylamino)propyl]oxy}-6- 1H), 9.97 (s, 1H), 8.51 (s, 1H), 7.82 (dd, 1H), (methyloxy)quinazolin-4- 7.64 (m, 2H), 7.54 (s, 1H), 7.48 (m, 1H), 7.41 43 yl]oxy)-3-fluorophenyl)-N'-(4- (m, IH), 7.37 (s, 11), 7.15 (t, 2R), 4.23 (t, 2R), fluorophenyl)-2,2- 3.97 (s, 3H), 2.56 (m, 211), 2.46 (m, 4H), 1.91 dimethylcyclopiopane-1,1- (m, 2M), 1.58 (m, 2H), 1.18 (s, 6H), 0.96 (t, dicarboxamide 61). N-(4-{[7.-{[3- 1H NMR (CDC13): 8.57 (s, 1H), 8.50 (s, 1H1), (diethylamino)propyl]oxy}-6- 8. 11 (s, 1H), 7.81 (dd, 1), 7.53 (m, 3H), 7.28 44 y1]oy}3-fluorophenyl)-N(4- (in, 4), 7.04 (t, 2R), 4.24 (t, 2H), 4.04 (s, 3H), fluorophenyl)cyclobutane--1,1- 2.95 (t, 2H), 2.84 (q, 4H), 2.75 (m, 411), 2.21 dicarboxamide (m, 2H), 2.02 (m, 21), 1.18 (t, 6H1). N-{3-fluoro-4-[(6-(methyoxy)- 1H NMR (CDCL3): 8.57 (s, 11), 8.49 (s, 111), 7-{[3-(4-methylpiperazin-1- 8. 10 (s, 111), 7.80 (c, 111), 7.70 (br., 11), 7.52 45 yl)propyI]oxy)quinazon-4- (in, 3H), 7.31 (m, 3H), 7.04 (t, 2H), 4.26 (t, fluorophnyylu , 2H), 4.04 (s, 3H), 2.62-2.77 (m, 141), 2.40 (s, dicarboxanide 3H), 2.13 (m, 2), 2.01 (m, 2R). (2R,3R)-N-[3-fluoro-4-({ 6- 1 H NMR (400 MHz, CDC1 3 ) d 8.59 (s, 1 K), (2ethyl3xy)-7-[(3-orpholin-4- 8.11 (br s, 11), 7.80-7.76 (m, 2 H), 7.53 (s, 1 ylpropyl)oxy]quinazoin-4- H), 7.50-7.46 (m, 2 K), 7.34 (s, 1 H), 7.26-7.24 46 yl)oxy)pheny aln-N(4- (m; 2 H), 7.06-7.00 (m, 2 K), 4.28 (t, I = 6.6 flu4y ophenyl)-Z3- Hz, 2 H), 4.05 (s, 3 H), 3.73 (br t, J= 4.4 Hz, 4 diinetliylcyclopropane-1, 1- H), 2.57 (t, J = 7.0 Hz, 2 H), 2,52-2,45 (m, 4 dicarboxamnide K), 2.18-2. 10 (m, 2 ), 1.80-1.68 (, 2 H), .1.28-1.20 (m, 6 H). N-(4{ 13-H NMR (400 MHz, DMSO-do): 9.98 (s, 1H), yN-(p4 oy71 -6- 9.72 (s, 1W), 8.45-8.43 (d, 1K), 7.97-7.94 (dd, (diethylyqinoli-yloxy 1H), 7.73-7.69 (m, 2), 7.65-7.52 (m, 3H), 47 7.44-7.39 (m, 1H), 7.18-7.14 (in, 2H), 6.43 3-fluorophenyl)-N'-(4- 6.42 (d, 1H), 4.20-4.19 (t, 2H), 3.95 (s, 3H), dicarboxamide 2.70-2.66 (m, 6H), 2.45 (br s, 2), 1.91-1.84 _____xnd (m, 6H), 0.98 (br s, 6H). 260 WO 2005/030140 PCT/US2004/031523 Table Entry Name 'H-NMR N-{3-fluoro4-[(6-(methyloxy)- 'H NMR (400 MHz, DMSO-ds): 9.99 (s, 1), 7-{[3-(4-methylpiperazin-1- 9.73 (s, 111), 8.45-8.43 (d, 1H), 7.97-7.93 (dd, yl)propylloxy}quinolin-4- 1H), 7.73-7.69 (A, 2H), 7.65-7.52 (m, 2H), 48 7.44-7.38 (m, 2H), 7.18-7.14 (i, 21H), 6.43 yI)oxy~phenyl)-N-(4- 6.42 (d, 1H), 4.19-4.16 (t, 3H), 3.95 (s, 3H), fluorophenyl)cyclobutane-1,1- 2.70-2.66 (m, 4H), 2.47-2.33 (m, SH), 2.15 (s, 3H), 1.98-1.94 (m, 2H), 1.90-1.84 (m, 4H). (2R,3R)-N-(4-{[7-{[2- 'H NMR (400 MHz, CDC1 3 ) d 8.59 (br s, 1 H), (diethylamino)ethy]oxy}-6- 8.29 (br s, 1 H), 7.93 (s, 111), 7.77 (d, J= 10.8 (methyloxy)quinazolin-4- Hz,1 H), 7.53 (s, 1 H), 7.50-7.45 (m, 2 H), 49 yl~oxy)-3-fluoropheny)-N'-(4- 7.32 (s, 1 H), 7.26-7.22 (m, 2 H), 7.05-6.99 (m, 21H), 4.27 (t, J = 6.6 Hz, 2 11), 4.04 (s, 3 H), fluorophenyl)-2,3- 3.03 (t, J = 6.5 Hz, 2 H), 2.67 (q, J= 7.0 Hz, 4 dimethyleyclop ane-1,1- H), 1.80-1.70 (m, 2 H), 1.22 (br t, J = 5.3 Hz, 6 dicarboxamide H), 1.09 (br t, J = 7.2 Hz, 6 ). (H NMR (400 MHz, CDCla) d 8.58 (s, 1 H), (diethy n)propy]o y}-6- 8.40-8.36 (m, I H), 8.02-7.96 (m, 1 H), 7.80 (ethylxyqzin'" 1IA-- 7.75 (m, I H), 7.53 (s, 1 H), 7.52-7.50 (m, 2 0 yInoxy}-3 h ny - 1-1), 7.31 (s, 1 H), 7.28-7.20 (m, 2 H), 7.02 (t, J fluorophenyl)-2,3- =8.5 Hz, 2 H), 4:25 (t, J = 6.3 Hz, 2 ), 4.04 dimethylyclopropane-1, - (s, 3 ), 3.00-2.90 (m, 2 F, 2.88-2.80 (m 4 dicarboxamide m), 2.30-2.20 (m, 2 H), 1.76-1.68 (m, 2 H), 1.25-1.15 (m 12 H). 'H NMR (400 Mffz, CD CIs) d 8.47 (d, J =5.2 (2R,3R)-N-(4-{[7-{[2- Hz, 1 H), 8.17 (br s, 1 H), 7.80-7.74 (m, 2 H), (diethylamino)ethyl]oxy}-6- 7.55 (s, 1 H), 7.52-7.46 (m, 2 H), 7.42 (s, 1 H), (methyloxy)quinolin-4-yI]oxy)- 7.24-7.20 (m, 2 H), 7.05 (t, J = 8.6 Hz, 2 H), 51 3-fluorophenyl)-N'-(4- 6.38 (br d, J= 5.4 Hz, 1 H), 4.27 (t, J = 6.4 Hz, fluorophonyl)-2,3- 2 H), 4.03 (s, 3 H), 3.04 (br t, J = 7.2 Hz, 2 H), dimethylcyclopropane-1,1- 2.68 (q, J = 6.8 H, 4 H), 1.80-1.68 (m, 2 H), dicarboxamide 1.26 (d, J=6.4 Hz, 611), 1.09 (br t, J=7.2 Hz, 6H. N-(4-{[6,7- 1HNMR (DMSO-d6): 10.82 (s, 1H), 8.80 (d, bis(methyloxy)quinolin-4- 1H), 8.50 (t, 1H), 7.83 (d, 211), 7.74 (s, 1H), 52 y11oxyJpheny)-N'-[(4- 7.56 (s, 1H), 7.30-7.38 (m, 4H), 7.15 (t, 211), fluorophenyl)methyl]cyclopropa 6.80 (d, 1M), 4.32 (d, 2H), 4.04 (s, 3H), 4.03 (s, ne-1,1-dicarboxamide 3H), 1.42 (s, 4H). N-(4-{[6,7- 1H NMR (DMSO-d6): 10.62 (s, 1H), 8.79 (d, bis(methyloxy)quinolin-4- IH), 8.24 (t, 1H), 7.83 (d, 2H), 7.72 (s, 1H), 53 y1]oxy}phenyl)-N'-(2- 7.58 (s, 1H), 7.37 (d, 21), 6.76 (d, 1H), 4.04 (s, morpholin-4- 3H), 4.03 (s, 3H), 3.98 (m, 211), 3.66 (ri, 2H), ylethyl)cyclopropane-1,1- 3.49 (m, 4H), 3.25 (t, 211), 3.13 (br., 211), 1.42 dicarboxamide (d, 4H). 261 WO 2005/030140 PCT/US2004/031523 Table 3 Entry Name 'H-NMR N-(4-{[6,7- 1H NMR (DMSO-d6): 10.78 (s, 1H), 10.53 (s, bis(methyloxy)quinolin-4- 1H), 8.43 (d, 1H), 8.12 (d, 1h), 7.82 (d, 2H), 54 y1]oxy}pheny1)-N-[2- 7.49 (s, 1H), 7.37 (s, 1H), 7.20-7.28 (m, 31), (piperidin-1- 7.15 (dd, 1H), 7.01 (td, 1), 6.35 (d, In), 3.93 ylmethyl)phenyl]cyclopropane- (s, 3H), 3.92 (a, 311), 3.47 (a, 2H), 2.17 (br., 1,1-dicarboxamide 4H), 1.49 (m, 41), 1.41 (m, 4H), 1.32 (br., 211). N-(4--{[6,7- 1H NMR (DMSO-d6): 10.98 (s, 11), 10.56 (s, bis(methyloxy)quinolin-4- 1H), 8.42 (d, 1H), 8.10 (dd, 11), 7.81 (m, 2H), 55 yl]oxy}phenyl)-N'-[2- 7.49 (s, 1H), 7.37 (s, 1H), 7.17-7.27 (m, 41), (pyrolidin-l- 7.01 (td, 11), 6.35 (d, 111), 3.93 (s, 311), 3.92 ylnethyl)phenyl]cyclopropane- (s, 3H), 3.61 (s, 2H), 2.30 (br., 4H), 1.47 (br., 1,1-dicarboxamide 14H), 1.43 (M, 4H). N-(4-{[6,7- 1H NMR (DMSO-d6): 10.12 (s, 1H), 10.03 (s, bis(methyloxy)quinolin-4- 1H), 8.44 (d, I), 7.74 (d, 2), 7.57 (s, 111), 56 ylloxy}phenyl)-N'-[3- 7.53 (d, 1H), 7.48 (s, 1H), 7.37 (s, 1H), 7.21 (morpholin-4- (m, 3H), 6.98 (d, 111), 6.40 (d, 111), 3.93 (s, ylmethy1)phenyl]cyclopropane- 311), 3.92 (s, 3H), 3.56 (t, 4H), 3.41 (s, 2H), 1,1-dicarboxamide 2.34 (br., 4H), 1.48 (s, 4H). N-(4-{[6,7- IHNMR (DMSO-d6): 10.54 (s, 1H), 10.47 (s, bis(methyloxy)quinolin-4- 11), 8.43 (d, 111), 8.08 (d, 1), 7.78 (d, 210, 57 yl]oxy}phenyl)-N'-[2- 7.49 (s, 1H), 7.37 (d, 11), 7.18-7.30 (m, 4H), (morpholin-4- 7.03 (t, 1), 6.37 (d, 11), 3.94 (s, 3H), 3.93 (s, ylmethyl)phenyl]cyclopropane- 3H), 3.50 (s, 2H), 3.44 (br., 41), 2.20 (br., 4), 1,1-dicarboxamide 1.48 (d, 4H). N-(4-{[6,7- 1H NMR (DMSO-d6): 10.14 (s, 1H), 10.03 (s, bis(methyloxy)quinolin-4- 11), 8.44 (d, 11), 7.74 (d, 2), 7.62 (d, 2H), 58 yl]oxy}phenyl)-N'- 7.48 (s, 11), 7.37 (s, 111), 7.27-7.31 (m, 2H), phenylcyclopropane-1,1- 7.19-7.23 (in, 21), 7.05 (t, 10, 6.41 (d, 111), dicarboxamide 3.93 (s, 611), 3.92 (s, 311), 1.48 (s, 4H). N-[3-minointylphenyl-N- 1H NMR (400MHz, DMSO-d6): d 10.28 (s, (4-[6,7- INH), 10.19 (s, 1), 8.77 (m, 1H), 8.21 (m, 311), 59 bis(methyloxy)quinolin-4- 7.84 (m, 2H), 7.76 (m, 1H), 7.71 (m, 1H), 7.58 (i, 2H), 7.38 (m, 3H), 7.19 (m, 11), 6.76 (m, y ,phenyyoppane- 11), 4.03 (s, 6H), 3.39 (m, 2H), 1.53 (m, 4H). oNote: all peaks are very bwad and unresolved. N-(4.-{[6,7- 1H NMR (DMSO-d6): 10.0-10.2 (br., 2H), bis(methyloxy)quinolin-4- 8.46 (d, 1H), 7.76 (d, 2H), 7.53 (n-, 3), 7.39 60 yl]oxy}phenyl)-N'-[3- (s, 11), 7.24 (m, 3H), 6.98 (d, 1H), 6.43 (d, yepenlcoro 1H), 3.95 (s, 31), 3.93 (s, 3H), 3.37 (s, 2H), yb1ethyl)peylcyclopropane- 2.31 (br., 4H), 1.48 (m, 8H), 1.39 (br., 2H). -dicarboxanide I262 262 WO 20051030140 PCT/US2004/031523 Table 3 Entry Name 1 R-NMR N-(4-{[6,7- 1H NMR (DMSO-d6): 10.0-10.2 (br., 2H), bis(methyloxy)quinolin-4- 8.46 (d, 1H), 7.77 (d, 2H), 7.59 (s1), 7.53 (d, 61 yl]oxy}phenyL)-N'-[3- 1H), 7.51 (s, 1H), 7.39 (s, 1H), 7.23 (m, 3), (pyzrolidin-1- 6.99 (d, 1H), 6.43 (d, 1H), 3.95 (s, 3H), 3.93 (s, ylmethyl)phenyl]cyclopropane- 3M), 3.52 (s, 2H), 2.42 (br., 4H), 1.69 (br, 4H, 1,1-dicarboxamide 1.48 (s, 4H). Assays [0455] Kinase assays were performed by measurement of incorporation of y- 33 P ATP into immobilized myelin basic protein (MBP). High binding white 384 well plates (Greiner) were coated with MBP (Sigma #M-1891) by incubation of 60ul/well of 20pg/ml MBP in Tris-buffered saline (TBS; 50mM Tis pH 8.0, 138mM NaCl, 2.7mM KCI) for 24 hours at 4" C. Plates were washed 3X with 1OpI TBS. Kinase reactions were carried out in a total volume of 34pl in kinase buffer (5mM Hepes pH 7.6, 15mM NaC, 0.01% bovine gamna globulin (Sigma #1-5506), 10mM MgC 2 , ImM DTT, 0.02% TritonX-100). Compound dilutions were performed in DMSO and added to assay wells to a final DMSO concentration of 1%. Each data point was measured in duplicate, and at least two duplicate assays were performed for each individual compound determination. Enzyme was added to final concentrations of 1OnM or 2OnM, for example. A mixture of unlabeled ATP and y 3P ATP was added to start the reaction (2x10 6 cpm of y3P ATP per well (3000Ci/mmole) and either 10pM or 30pM unlabeled ATP, typically. The reactions were canied out for 1 hour at room temperature with shaking. Plates were washed 7x with TBS, followed by the addition of 50pl/well scintillation fluid (Wallac). Plates were read using a Wallac Trilux counter. This is only one format of such assays, various other formats are possible, as known to one skilled in the art. [0456] The above assay procedure can be used to determine the ICso for inhibition and/or the inhibition constant, K. The IC5o is defined as the concentration of compound required to reduce the enzyme activity by 50% under the conditions of the assay. Exemplary compositions have ICs 5 's of, for example, less than about 100 pM, less than about 10 jpM, less than about 1 M, and further for example having ICso's of less than about 100 nM, and still further, for example, less than about 10 nM. The Ki for a compound may be 263 WO 20051030140 PCTUS2004/031523 determined from the ICo based on three assumptions. First, only one compound molecule binds to the enzyme and there is no cooperativity. Second, the concentrations of active enzyme and the compound tested are known (i.e., there are no significant amounts of impurities or inactive forms in the preparations). Third, the enzymatic rate of the enzyme-inhibitor complex is zero. The rate (i.e., compound concentration) data are fitted to the equation: V = V.E0 (E±+I+Ka) (Eo+4+K9)2_4Eo1a 2E where V is the observed rate, V., is the rate of the free enzyme, Io is the inhibitor concentration, ED is the enzyme concentration, and Kd is the dissociation constant of the enzyme-inhibitor complex. Kinase specificity assays: [0457] Kinase activity and compound inhibition are investigated using one or more of the three assay formats described below. The ATP concentrations for each assay are selected to be close to the Michaelis-Menten constant (Km) for each individual kinase. Dose response experiments are performed at 10 different inhibitor concentrations in a 384-well plate format. The data are fitted to the following four-parameter equation: Y=Min+ (Max - Min) /(1 + (XICsO)AH) where Y is the observed signal, X is the inhibitor concentration, Min is the background signal in the absence of enzyme (0% enzyme activity), Max is the signal in the absence of inhibitor (100% enzyme activity), ICso is the inhibitor concentration at 50% enzyme inhibition and H represents the empirical Hill's slope to measure the cooperativity. Typically H is close to unity. c-Met Assay [0458] c-Met biochemical activity was assessed using a Luciferase-Coupled Chemiluminescent Kinase assay (LCCA) format as described above. Again, kinase activity was measured as the percent ATP remaining following the kinase reaction. 264 WO 2005/030140 PCT/US2004/031523 Remaining ATP was detected by luciferase-luciferin-coupled chemiluminescence. Specifically, the reaction was initiated by mixing test compounds, 1pM ATP, 1pM poly EY and 10nM c-Met (baculovirus expressed human c-Met kinase domain P948-S1343) in a 20uL assay buffer (20mM Tris-HCL pH7.5, 10mM MgC 2 , 0.02% Triton X-100, 100mM DTT, 2mM MnC2). The mixture is incubated at ambient temperature for 2hours after which 2OuL luciferase-luciferin mix is added and the chemiluminescent signal read using a Wallac Victo? reader. The luciferase-luciferin mix consists of 50 mM HEPES, pH 7.8, 8.5ug/mL oxalic acid (pH 7.8), 5 (or 50) mM DTT, 0.4% Triton X-100, 0.25 mg/mL coenzyme A, 63 uM AMP, 28 ug/mL luciferin and 40,000 units of light/mL luciferase. KDR Assay [0459] KDR biochemical activity was assessed using a Luciferase-Coupled Chemiluminescent Kinase assay (LCCA) format. Kinase activity was measured as the percent ATP remaining following the Idnase reaction. Remaining ATP was detected by luciferase-luciferin-coupled chemiluminescence. Specifically, the reaction was initiated by mixing test compounds, 3 pM ATP, 1.6 pM poly-EY and 5 nM KDR (baculovirus expressed human KDR kinase domain D807-V1356) in a 2OuL assay buffer (20mM Tris HCL pH7.5, 10mM MgC12, 0.01% Titon X-100, 1mM DTT, 3mM MnC 2 ). The mixture is incubated at ambient temperature for 4 hours after which 20uL luciferase-luciferin mix is added and the chemiluminescent signal read using a Wallac Victor 2 reader. The luciferase-luciferin mix consists of 50 mM HEPES, pH 7.8, 8.5ug/mL oxalic acid (pH 7.8), 5 (or 50) mM DTT, 0.4% Triton X-100, 0.25 mg/mL coenzyme A, 63 uM AMP, 28 ug/mL luciferin and 40,000 units of light/mL luciferase. flt-4 Assay [0460] Biochemical activity for flt-4 was assessed using an Alphascreen Tyrosine Kinase protocol. AlphaScreenTM (Perkin Elmer) technology is a proximity assay employing microparticles. Singlet oxygen derived from a donor bead following laser excitation results in chemiluminescence when in proximity (100 A) to an acceptor bead due to biomolecular interactions. For the Flt-4 assay, donor beads coated with streptavidin and acceptor beads coated with PY100 anti-phosphotyrosine antibody were used (Perkin Elmer). Biotinylated poly(Glu,Tyr) 4:1 (Peddn Elmer) was used as the substrate. 265 WO 2005/030140 PCT/US2004031523 Substrate phosphorylation was measured by addition of donor/acceptor beads by chemiluminescence following donor-acceptor bead complex formation. Test compounds, 5 pM ATP, 3 nM biotinylated poly(Olu, Tyr) and 1 nM Ft-4 (baculovirus expressed human Flt-4 dnase domain D725-R1298) were combined in a volume of 20 pL in a 384 well white, medium binding microtiter plate (Greiner). Reaction mixtures were incubated for 1 hr at ambient temperature. Reactions were quenched by addition of 10 uL of 15-30 mg/mL AlphaScreen bead suspension containing 75 nM Hepes, pH 7.4, 300 mM NaCl, 120 mM EDTA, 0.3% BSA and 0.03% Tween-20. After 2-16 hr incubation at ambient temperature plates were read using an AlphaQuest reader (Perkin Elmer). ICSO values correlate well with those determined by radiometric assays. fMt-3 Assay [0461] Biochemical activity for flt-3 was assessed using a Luciferase-Coupled Chemiluminescent Kinase assay (LCCA) format. Kinase activity was measured as the percent ATP remaining following the Idnase reaction. Remaining ATP was detected by luciferase-luciferin-coupled chemiluminescence. Specifically, the reaction was initiated by mixing test compounds, 5 pM ATP, 3 pM poly-BY and 5 nM FIt-3 (baculovirus expressed human FIt-3 kinase domain R571-S993) in a 20uL assay buffer (20mM Tis HCL pH7.5, 10mM MgCl 2 , 0.01% Triton X-100, 1mM DTT, 2mM MnCl2). The mixture is incubated at ambient temperature for 3 hours after which 20uL luciferase-luciferin mix is added and the chemiluminescent signal read using a Wallac Victor? reader. The luciferase-luciferin mix consists of 50 mM HEPES, pH 7.8, 8.5ugImL oxalic acid (pH 7.8), 5 (or 50) mM DTT, 0.4% Triton X-100, 0.25 mg/mL coenzyme A, 63 uM AMP, 28 ug/mL luciferin and 40,000 units of light/mL luciferase. c-Kit Assay [0462] c-Kit biochemical activity was assessed using AlphaScreen Tm (Perkin Elmer) technology, described above. Test compounds, ATP, biotinylated poly(Glu, Tyr) and c Kit kinase were combined in a volume of 20 pL in a 384-well white, medium binding microtiter plate (Greiner). Reaction mixtures were incubated for 1 hr at ambient temperature. Reactions were quenched by addition of 10 uL of 15-30 mg/mL AlphaScreen bead suspension containing 75 mM Hepes, pH 7.4, 300 mM NaCl, 120 mM 266 WO 2005/030140 PCT/US20041031523 EDTA, 0.3% BSA and 0.03% Tween-20. After 16 hr incubation at amiient temperature plates were read using an AlphaQuest reader (Perldn Elmer). Structure Activity Relationships [0463] Table 4 shows structure activity relationship data for selected compounds of the invention. Inhibition is indicated as IC5o with the following key: A = ICso less than 50 nM, B = IC 5 o greater than 50 nM, but less than 500 riM, C = ICso greater than 500 nM, but less than 5000 nM, and D IC o greater than 5,000 nM. Depending upon the functionality about the quinazoline or quinoline, exemplary compounds of the invention exhibit selectivity for any of c-Met, KDR, c-Kit, fit-3, and flt-4. Abbreviations for enzymes listed in Tables 2-3 are defined as follows: c-Met refers to hepatocyte growth factor receptor kinase; KDR refers to kinase insert domain receptor tyrosine kinase; flt-4, fms-like tyrosine kinase-4, representative of the ELK family of receptor tyrosine idnases; c-Kit, also called stem cell factor receptor or steel factor receptor; and flt-3, fins-like tyrosine kinase-3. Empty cells in the tables indicate lack of data only. Table 4 Name N-[({3-fluoro-4-[(6-(methyloxy)-7-{[(3aR,6aS) octahydrocyclopenta[c]pyrrol-5 1 ylmethyl]oxyjquinazolin-4- A A yl)oxy]phenylamino)carbonothioyl]-2 phenylacetamide N-{ [(3-fluoro-4-{[7-(( [(3aR,6aS)-2 methyloctahydrocyclopenta[c]pyrrol-5 2 yl]methylloxy)-6-(methyloxy)quinazolin-4- A A A A yl]oxy}phenyl)amino]carbonothioyl}-2 phenylacetamide N-{[(4-{[6,7-bis(methyloxy)quinolin-4-yloxy}-3 3 fluorophenyl)(methyl)amino]carbonothioyl}-2- C phenylacetamide 4 1-(4-([6,7-bis(methyloxy)quinolin-4-yloxy}-3- C C C fluorophenyl)imidazolidin-2-one 5 1-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}-3- C B C fluorophenyl)-3-(phenylmthyl dazolidin-2-one 6 1-(4-{[6,7-bis(methyloxy)quinolin-4-ylloxy}-3- B fluorophenyl)-3 -(phenylacetyl)imnidazolidin-2-one 267 WO 2005/030140 PCT/US2004/031523 7 e thyl [(4-f [6.7-bis(methykvxy)quinofn4ylloxy}-3- B B C 13 flnorophonyl)aminol(oxo)acetate N-{ [(4-f [6,7-bismothyloxy)quinazdin4.y1]anino}-3 8 flnorophenyl)aminojcarbonotbioyl)-2- A B C B phenylacetaniide 9 N'-(4-{ [6,7-bis(methyloxy)quinolin-4-yl]oxy)-3- c __fluorophenyl)-N-methyl-N-(2-phenyleothyl)sulfamide - - N-(4-{ [6,7-bia(methyloxy)quinolin4-yl]oxy)-3 10 fluorophenyl)-3-(phenylmiethyl)-1,2,4-oxadiazol-5- C B3 C amine 11 1-(4-f [6,7-bis(methyloxy)quinoin-4-yl]oxy}-3 11 ~fluorophenyl)ppiddin-2-one c c 12 N-(4-{ [6,7-bia(methyloxy)quinoln-4-yI]oxy}-3- B B B C B 12fluorhony1)Nphenylethy)ethaediamB BC 13 N-(4-{ [6,7-bia(methyloxy)quinolin-4-yljoxy}-3 c CC B fluorophenyl)-4-phenyl-1,3-thiazol-2-amine 14 N-Q1-{ [6,7-bia~nethiyloxy)quinolln-4-yl]oxy)-3- A A A C A __ fluorophenyl)-N'-(2-phenylethyl)ethanediamide 15 N-(4-{[6,7-bis(methyloxy)quiaoliD4-ylloxy}-3- CC B 15 fluorophenyl)-1-phenylmethanesulfonamide c B 16 N-(4-{ [6,7-bia(methyloxy)quinolin4-ylloxy}-3- c c flnorophenyl)-2-phenylethaneaulfonamide I -I 17 4-f [6,7-bis(methyloxy)quinoliii-4-ylloxy)-3-fluoro-N- c c (phenylmethyl)benzenesulfonamicle c 18 4-f [6,7-bis(methyloxy)quinolin-4-yljoxyj-3-fluoro-N- c c znethyl-N-(phenylnethyl)benzenesulfonamide CC C 14-f ,-i~etyoyqioh4y~x)3-looN' 19(2-phenylethyl)benzeneslfonamide IC C C S4-{ [6,7-bia(methiyloxy)quinolin-4-yl]oxy}-3-fluoru-N 20 methyl-N- (2-phenylethyl)benzenesulfonami'de C CC 21 4-f [6,7-bis(mthyloxy)quhxolin-4-ylloxy)-3-fluoro-N (3-phenylpropyl)benzeneaulfonanideC 22 1-(4-{ [6,7-bis(methyloxy)quinolin-4-yl]oxy)-3- C C B fluorophenyl)pyrrolidin-2-one 23 4-f [6,7-bia(methyloxy)quinolin-4-ylloxy~pbenyl C (phenylmethyljcarbamate 24 4-f[ [6,7-lis(methylaxy)quinolin-4-yljoxy}pheny (2- C phenylethyl)oarbaniate 25 4-f [6,7-bia(methyloxy)quinolin-4-yloxy) -3-fluoro-N- C methyl-N-(3-phenylpropylbenznesulfonamide-- 26 N-(4-{[6,7-bis(methyloxy)quinolin-4-yljoxy} 3- B D C C fluorophenyl)-N-phenylethanedianide 27 4-f [6,7-bia(methyloxy)quinoliu-4-yllamino}-N-(3- c pbenylpropyl)benzamnide 268 WO 2005/030140 PCT/UJS2004/031523 N-{[(3-fluoro-4-f[7-{[(2 methylactahydrocyclopenta[c]pyrrol-5 28 yl)methyl]oxy}-6-(methyloxy)quinolin-4- A A A A A yl]oxy}phenyl)amino]carbonothioy}-2phenylacetamide N-[(Z)-[(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}-3 29 fluorophenyl)amino](imino)methyl]-2- C phenylacetamide 30 4-f [6,7-bis(methyloxy)quinolin-4-y]oxy}-3-fluoro-N- C [2-(phenyloxy)ethyl]benzenesulfonamide 31 This type of multiplicative nomenclature is not c supported in current version! 32 N-(4-f [6,7-bis(methyloxy)quinolin-4-yl]oxy}-3- C fluorophenyl)-3-phenylpropane-1-sulfonamide N-2--[(4-{[6,7-bis(methyloxy)quinolin-4-ylloxy}-3 fluorophenyl)sulfonyl]-N-phenylglycinamide 34 N-(6-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}pyidin- C 3-yl)-2-phenylacetamide N-{[(6-{[6,7-bis(methyloxy)quinolin-4 35 yl]oxy)pyridin-3-yl)amino]carbonothioyl}-2- A C D C phenylacetamide 36 6-{[6,7-bis(methyloxy)quinolin-4-ylloxy}-1,3- C c c benzothiazol-2-amine 37 6-{ [6,7-bis(methyloxy)quinolin-4-yloxy}-5-fluoro- C C 1,3-benzothiazol-2-amine 38 N-(6-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}-5- B C D B fluoro-1,3-benzothiazol-2-yl)-2-phenylacetamide N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}-3 39 fluorophenyl)-N'-(2-morpholin-4- C B B ylethyl)ethanediamide 1,1-dimethylethyl (2-[(4-{[6,7 40 bis(methyloxy)quinolin-4-yl]oxy}-3- C fluorophenyl)amino]-2 oxoethyl}(phenylmethyl)carbamate 41 N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxyl-3- B fluorophenyl)-N-2--(phenylmethyl)glycinamide N-2--acetyl-N-(4-{[6,7-bis(methyloxy)quinolin-4 42 yl]oxy}-3-fluorophenyl)-N-2-- C (phenylmethyl)glycinamide 43 N-(6-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}-1,3- B benzothiazol-2-yl)-2-phenylacetamide 1,1-dimethylethyl {2-[(6-{[6,7 44 bis(methyloxy)quinolin-4-yl]oxy}pyridin-3-yl)amino]- C 2-oxoethyl}(phenylmethyl)carbamate 45 N-(6-([6,7-bis(methyloxy)quinolin-4-yI]oxy}pyridin- C 3-yl)-N-2--(phenylmethyl)glycinamide 269 WO 2005/030140 PCT/U52004/031523 N'-2--acetyl-N-(6-{ [6,7-bis(methyloxy)quinolin4 46 yljoxyjpyridin-3-yl)-N-2.-- C 3-1(3phenyropaglcnaxide, 47 N-(6-f [6,7-big~methyloxy)quinoln-4-yljoxypyidin 3-yl)-4-phonylbutanamileC 48N-(6-f[6,7-bis(methyloxy)quinoin-4-yloxylpyridin- c - - - 'i9~~~ 3-yl)-N-4ty-.2phnyltnametyglc md 49 N-(- [6,7-bis(methyloxy)quinoin4yloxy)pri-3 (-l--mthyly-pheny eylithed iade e N-(4-{ [6,7-his (methyloxy)quinolin-4-y]oxy}-3 51 fluorophenyl)-N'-eh-N2- B A B (mtyophenylethyl)ycineian N- (4-f [6,7-bis(methyloxy)quinolin-4-ox-3 52 yluiouphonyl)aN-micbnothyl}-2-- A B B C A phenyletlgnamide N-f [(- 6,7-is(methyloxy)quinolin-4-oy}5 54 oboy idin-3-hoyl)amino]carbonothioyl)-2- A B B C B phenylacetanide 53 N-(6-{[6,7-bis(methyloxy)quinolin4-ylloxyj -3 55 fuoroph3-enztiol2yl)- 3-h yro-1- nden-1-A B B pylaetdamide N-(4-f [6,7-bis(methyloxy)quinolin-4-ylloxyj -3 56 fluorophenyl)-N'-(2,3-dihydro-1H-inden-2- AC yl)ethanedianiide N-(4-f [6,7-bis(methyloxy)qunolin-4-yljoxy}-3 57 fluorophenyl)-N-(A3-tetrhydronaphthaln-1- B c yl)ethanedianiide N-(4-f [6,7-bis(methylhxy)quinolin-4-yljoxy}-3- 17 57 fluorophenyl)-N-(2-pheyletrhyoaal)-N - .06C heyethy1)suiamide S N'-(4-{ f6,7-bismthyloxyquinoin4-yJoxy-3 14B70 B 58 fluoropheny)-N- -ptnfloro ety)-cN-md -0 60 N--(4-f 6,7-bis(methyloxy)quinolin-4-yloxy-3- B A A A B .fluorophenyl)amino]-2-oxoethyllbenzamide 61 N-(6-ff6,7-bisonethyloxy)quinolin-4-yl]oxy}pyridin- A B B B 3-yl)-N'-(4-flnorophenyl)propanediamide- - N-(4-f f6,7-bis(methyloxy)quinolin-4-yl~oxyl -3 62 fluorophenyl)-N'-I(2S)-1,2,3,4-tetreydronaphtbalen-2- C yIlethanecliamaide 270 WO 2005/030140 1CTf052004/031523 N-(4-{ [ 6 1 7-bis(xethyloxy)quinolin-4-yl]oxy}-3 63 fluorophenyl)-N'-[2-(4- C C C methylphcnyl)ethyfletbaediamide 64_ fluorophenyl)-N'-(2-phenylpropyl~ehanediamide B_ A B B N-(4-{ [6,7-bis(methyloxy)quinolin-4-yl]oxy}-3 65 .fluorophenyl)-N'-[2-(4- A C B C C chloropbenylethyllothaediamide 66 N-(4-{ [6,7-bis(methyloxy)quinolin-4-yI~oxyj-3- c fluorophenyl)-N,N'-bis(pheuybnethyl)sulfarmde 67 N-(4-{ [6,7-bis(naetbyloxy)quinolin-4-ylloxy}-3- c fluoophcnyl)-N,N-bis(2-phanylethyl)sulfwnide 68 ethyl [(6-{ [6,7-bis(methyloxy)quinolin-4-yfloxy)-5- c chloropyridin-3-yl)aninoj(oxo)acetate 69 N-(6-{ [6,7-bis~nethyloxy)quinolin-4-yl]oxy}-5- c __chloropyridin-3-yl)-N'-(2-phenylethy)ethanediamide N-(6-{ [6,7-bis(methyloxy)quinolin-4-yIloxy}-5 70 chloropyddin-3-yl)-N'-(4- A B B C fluoropbenyl)propanediamide N-(4-( (6,7-bis~nethyloxy)quinolin-4-yI]oxy}-3 1 71 fluorophenyl)-N'-((2R)-1,2,3,4-tetrahydronapbthalen- B D B C 2-yl]ethaecliamide- - - N-(4-{ [6,7-bis(methyloxy)quinoli-4-ylloxy)-3 72 fluorophenyl)-N'-f2-(1-methyipyrrolidin-2- C C C I yl)ethyllethanedianuide S N-QI- ( [6, 7-biu(methyloiy)quinolin-4-ylloxyJ-3- B B BC __flucrophenyl)-N'-[2-(phenyloxy)ethyl]ethanedianide -N-(4-([6,7-bis(methyloxy)quinolin-4-y1Joxy}-3 74 fluorophenyl)-N'-[2-hydroxy-1- B (phenylmethyl)ethyl]urea 1-(4-{ [6, 7-bis~methyloxy)quinolin-4-yl]oxy}-3 75 fluoropbenyl)-3-[(4-methylpbenylaulfony)-4- B B- B B3 B Ophnylmethy)inidazolidin-2-on - N'-(4-{ [6, 7-bis(meffiyloxy)quinolin-4-yl]oxyj -3 76 fluowophonyl)-N-methyl-N-(2- A B B B B phenylethyl)ethaedamde N-(4-{ [6,7-bis(methyloxy)quinoin-4-ylloxy}-3 77 fluorophenyl)-N'-([3- B B B (triluromethyl)phenyllmethyl)ethanedamide N(-[6,7-bis(methyloxy)quinolin4-ylIoxy)-3 78 fluorophenyl)-N'-{2-[3- C A B I (triflomethyl)pbenyllethylletbanediamide 79 N-(6-{ [6,7-bis(mnethyloxy)quinolin-4-ylloxy}-5 chlorapyridin-3-yl)-3-oxo-4-phenylbutanarniide c 271 WO 2005/030140 PCTIUS2004/031523 N-(6-{ [6,7-bie(methylox.y)quinoin-4.yljoxy}-5 80 . chloropy~din-3-y1)-2%[3- C (triflnoromethyl)phenyllacetomide 816-{ [6,7-bis(methyloxy)quinolin-4-yljoxy}-5-fluoro-N- B (2-(,Pheayloxy)ethyl]-1,3-benzotblazol-2-amine 82 6-f [6,7-bis(methyloxy)quinolin-4-yl]oxyj-5-fluoro-N __ (2-piperidin-1-ylethyl)-1,3-benzothiazol-2-amine C 83 6-{[ f67-bis(methyloxy)quinolin-4-yljoxy}-5-fluoro-N- c methyl-N-(2-pbenylethyl)-1 ,3-benzothiazol-2-amiue 84 6-{ [6,7-bis(methyloxy)quinolinA-yl]oxyl-5-tluoro-N __(2-pynrolidin-1-ylethylD-I,3-benzothiazol-2-amine 6-f [6,7-bis(methyloxy)quinolin4-yl]oxy}-5-fluoro-N 85 {([3-(trifluoromethiyl)phenyllznethylj-1,3-bemwtbiazol- C 2-amnine 6-{ [6,7-bis(methyloxy)qninolin-4-ylloxy}-5-flwro-N 86 {2-[3-(trifluoromethyl)phenyl]ethyl) -1,3-benzotbiazol- C 2-amine N-(6-{ (6,7-bis(methyloxy)quinolin-4-yl]oxy) -5 87 chloropyridin-3-yl)-N'43- C (trifluoromethyl)phenyllprpanediamide - - N-(6-{ [6,7-bis(methyloxy)quinolin-4-yIloxy)-5 88 fluoro-1,3-benzotbiazol-2-yl)-2-[3- C A B B B (trfluoronithyl)phenyl]acetamide N-.(4-{ [6,7-bis(methyloxy)quinolin4-yl)oxy}-3 89 fluorophenyl)-N-2--{[3- B A B B A (tifluomomethyl)phenyl]methyl }glycinanideII I 90 N-(4-{ [6,7-bis(methyloxy)quinoln-4-yIloxy}-3- B fluorophenyl)-N-2--(2-phenylethyl)glycinarnide N-(4-{ [6,7-bis(methylox-y)quinolin-4-yl]oxy}-3 91 fluorophenyl)-N-2--(2-[3- B B B B A (tfluoromethyl)pbeuyl]ethyllglycinamide 1, 1-dimethylethyl {2-[(6-f[[6,7 92 bis(methyloxy)quinolin-4-yl]oxy} -5-ohloropyridin-3- C yl)aminoJ-2-oxoethylj (phenylmetbyl)carbemate 93 N-(6-{ [6,7-bis(methyloxy)qulnolin-4-yl]oxyj-5- c luor-3-be)Nzot(hiazol2-yl)-[35- C B D N-(6-( [6,7-bis(methyloxy)quinoi-4-ylloxy}-5 95 fluoo-1,3-benzotiazol-2-yl)-2-[hlr5- AC B B B bi(trifluormethyl)phenylacetamide N- (3-fluoro-4-[(6-(melhyloxy)-7- I[(1 96 methylpipezlin-4-yl)methylloxylquinolin-4- A A A A A yl)oxy]phenyl}-N-(2-phenylethyl)ethanedianide 272 WO 2005/030140 PCTW[SZOO4/031523 N-(4-{ [6,7-bis(methiyloxy)quilolin-4-yljoxy}-3 97 fluorophenyl)-N'-(1,2,3,4-tetrahydroisoquinolin-1- C ylmethyl)ethanediamide N-(4-{ [6,7-bis,(xnethyloxy)quinolin-4-yl]oxy} -3 98 fluoropheny)-N'-[2-methy1-1,2,3,4- B B B A B itetrahydroisoquinolin-1-yl)uwthyllethanediamide N-(4-{ [6,7-bisgmethyloxy)quinolin-4-yl]oxy}-3 99 fluorophenyl)-N-2--methyl-N-2-- ff3- C __ (irifluorome-thyl)phenyljmcthyllglycinamide N-(4-{ r6,7-bis(mthyloxy)qtnohi-4-yl]oxy}-3 100 fluorophenyl)-N-2--niethy-N-2--{2-P[- c (trifluoromethyl)phenyljcthyl)glyoinamide - N-(4-{ [6,7-bis(methyloxy)quinolin-4-yfloxy.}-3 101 fluorophenyl)-N-2--nethyl-N-2--(2- C phenylethyl)glycinarnide- - 102 1-(4-f([6,7-bis(miethyloxy)quinolin-4-yl]oxy) -3- B B B B C fluorophenyl)-4-(phenylmethyl)bnidazolidin-2-one N-(6-{ [6,7-bis(methyloxy)quinolin-4 103 y1]oxy~pyridazin-3-y1)-Nt(4- A C B A C fluorophcnyl)propauediamide N-(6-{ [6,7-bis(methyloxy)quinolin-4-yI]oxy)-5 104 chlorupyiidin-3-yl)-'- (2- B chlorophenyl)propanedamide N-(6-{ [6,7-bis(methyloxy)quinoin-4-yljoxy}-5 105 chloropyzidin-3-yI)-N'-(3- C chloropheny)propanediaunide N-(6-{ [6,7-bis(methyloxy)quinolin4-yl]oxy}-5 106 ohloropyridin-3-yl)-N-2-methyl-N--2-- C (phenylmethyl)glydinamide N-(6-{ [6,7-bis(methyloxy)quinoin-4-yl]oxy} -5 107 cliloropyzidin-3-yI)-N'-(4- B clilorophenyl)propanedieniide-- 18 (2E)-N-(4-{ [6,7-bis~ntbyloxy)quinoin4 ___ylloxy~phenyl)-2-[(inethyloxy)imino]propanamide B B 109 (2E)-N-(4-{ (6,7-bis(methyloxy)quinobin-4- B yLjoxyj phenyl)-2-[(othyloxy)iminolpropanamide B A (2E)-N-44-( [6,7-bis(mthyloxy)qtin-4 110 ylloxylphenyl)-2- B B ___ f [(phenylmethyl)oxy]imino )propanamide SN-(4-{[6,7-bis(methyloxy)quinolin-4-yl~oxy)phenyl)- c I-(4-{ [6,7-bis(mcthyloxy)quinolin-4-yI]oxylpbenyl) 1121 3-[(4-metbylphenyl)sulfonyl]-4- B C B C C (phcnylmethy1)imidazolidin-2-one 113 1-(4-{ [6,7-bis(methyloxy)qulnolin-4-yIloxylpbenyl)- c 4-(phenyimethyl)imidazolidin-2-one 273 WO 2005/030149 PCT/UJS20041031523 F14 N-(4-{ [6,7-bis(methyloxy)quinolin-4-yfloxy~phenyl)- C B __ 4-(phenyhmethyl)-4,5-dihycfro-1,3-oxazol-2-amine 1 115 6,7-bii(mthylosy)-4-((4-[4-(phenyhnothyl)piperazin- C C 1-yllphenylloxy)quinolino 116 1-(4-{ [6,7-bis(methyloxy)quinoliu-4-yloxylpheny1)- c 117 N-(4-f [6, ebismthy)uprnol2yoxyeny. - N44-{ [6,7-bis(methyloxy)quinoln4-yljoxyjphnyl 11 N'2'-rtlN-2--(phenylmethyl)alaninamide 119 N-(4-{ [6,7-bis(methyloxy)quinoin-4-yljoxylphenyl)- c N2-t-N-2--(phenyhyllianina d 19N-(4-f [6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)- C C ~ N2-metlN--2--(phlenylmty)leucinaid e 12 N-(4-{ [6.7-bis(mcthyloxy)quinolin-4-yljoxyjphcnyl)- c N#-2--(phenylmoth34)va~inamde N-[5-clilor6-6-({ 6-(methyloxy)-4-[(piperidi-4 122; ylmothyl)oxylquinolin-7-ylloxy)pyridin-3-yl]-N'-(4- C C fluorophenyl)propanodianiide 131-(4-(6,7-bis(methyloxy)quinolin-4-ylloxyjphenyl)- C C S4-(phenyhnethyl)tetrahydropyriniidin-2QHI-)-onc N-[3-fluoro-4-({6-(mthyloxy)-7-((piperidin-4 124 ylehloyqlon4-loypo31N-2 A A A A A phcnylethyl)ethanocliamide N-(6-{ [6,7-bis(mcthyloxy)quinolin-4-yl]oxy}-5 125 cliloropyiidin-3-yl)-N'-(4-fluorophcnyljcyclopropane- A A B A B 1,1-dicarboxamide N-(6-{ [6',7-bis(methyoxy)quinolin4-y1~xy} -5 126 chloropyridin-3-yl)-N-(4-fluorophony)oyclobutane- C C 1,1-dicarboxamide I7N-(4-{[6,7-bis(methyloxy)quinolin-4-y1]oxy~phonyl)- c V N-2--mothyl-N-'2--(phenylmethyl)valinanide 128 (ZE)-N- (4-f [6,7-bis(methyloxy)quinolin-4- C A yljoxy }pheny1)-2-[(phenyloxy)iminolpropanamide (2E)-N-(4-( [6, 7-bis(methyloxy)quinolin-4 129 yljoxylphenyl)-2-phenyl-2- B C I [(phenyhmethy)oxyimina)othanamide 130 6,7-bis(mothyloxy)-4-Q14-[4-(phenylmethyl)pipwridin- c 1-yljphenyl}oxy)quinolino e N-(4- {[6, 7-bis~nethyloxy)qui-nolin-4-ylloxy}-3 131 fluorophenyl)-N'-{ [2-(I-methylethyl)-1,2,3,4- B B teitrahydroisoquinolin-1-yllmethyl Jethanecliamide N-(4- { [6,7-bis(moethyloxy)quinolin-4-ylloxy}-3 132 fluorophenyl)-N'-[(2-ethyl-1,2,3,4- B C tetrahydroisoquinolin-1-yl)rnothyl~ethanediamide 274 WO 2005/030140 PCT11520041031523 1, 1-dimethylethyl 4-(f [4-f [3-chloro-5-((3-[(4 1331 fluorophenyl)eminoj-3-oxopropanayljamino)pyridin- B C 2-yl]oxy)-6-(methyloxy)quiolin-7 yl]oxylmethyl)pipeidie-1-oarboxylate N-11-clor-6-({ 6-(methyloxy)-7-[(pipeiidin-4-B A 134 ylmthy1)oxylquinolinA-y1}oxy)pyidin-3-y1]-NL(4~ fluorophenyl)propanediamicle N-f 5-obloro-6- [(6-(mcthyloxy)-7-f [(1 135 metbylpiporidin-4-yl)methylloxy~quinolin-4- A B B A yl)oxy]pyridin-3-yl}-N'-(4 fluorophenyl)propanediaxnide N-(4-f 17-f [3-(diethylamino)propylloxy}-6 136 (methyloxy)quinolin-4-yloxy}-3-fluorophwnyl)-N-(2- A A. A B A pheny4ethyl)effianediamide N-[3-flnoro-4-(f6-(me-thyloxy)-7-[(3-moiholin-4 137 ylpxopyl)oxy]quinolin4yljoxy)phenyfl-N-(2- A A A B A phenylethyl)ethanediemide N-[3-flo-4-(f6-Qnethyloxy)-7-[(3-piperidin-1 138 ylpropyl)oxyjquinolin-4-ylloxy)phenyl]-N'-(2- A A A A phenyletliyl)ethanediamide N-(4-f 17-f [2-(dicthylaniino)ethyl]axy}-6 139 (methylaxy)quinoiin-4-yfloxy} -3-f luorophenyl)-N'-(2- A A A A A phenyletbyl)ethanediamide fl'-{3-ftuoro-4-[(6-(methyloxy)-7-{ [(1 10 methylpipridin-4-yl)methylloxyjquinoln-4- A A B yl)oxy]phenyl }-N-methyl-N-(2 *phenylethyl)etbanediamide N-(3-fluomo-4-f [ 7-Q [(3aR,5r,6a5)-2 141 IflthyloctahydrocyclopentacpyP1715- A A A A A yIlmethyl )oxy)-6-(mothyloxy)quinolin-4 ylloxylphenyl)-N'-(2-phenylethyl)ethanediamide N-(3-fluoro-4-{ [7-({ [(3aR,6aS)-2 142 methylactahydrocyclopenta[clpynrol-5- A A A A A yl]methylloxy)-&(methyloxy)quinazolin-4 __ yl]axylphenyl)-N'-(2-phenylethyl)ethanodiamide 2-(3,4-dihydroisoquinaln-2(1J-y)-N-{3-fluoro-4 143 [(6-(methyloxy)-7-{ ((1-methylpiperidin-4- A A yI)methylloxylquinolln-4-yl)oxyjphonyll-2- A A oxoaoetamide N-[3-fluoro-4-ff 6-(methyloxy)-7-[(piperidin-4 144 ylmethyl)oxy]quinolin-4-yIloxy)phenyl]-2-oxo-2-(3- A A A A A phenylpynroidin- 1-yl)acetamide N-[3-fluoro-4-(( 6-(methyloxy)-7-[(piperidin-4 145 ylmethyl)oxy]quinolin4-ylloxy)phenyl]-2-oxo-2-(2- A B B B phenybnorpholin-4-yl)acetiide---- 275 WO 2005/030140 PCT/U52004/031523 N-[2-(dimethylamino)-2-phenylethyl]-N'43-fluoro-4 146 ({6-(methyloxy)-7-[(piperidin-4- .A A B A lyhnethyl)oxyjquinolin-4-ylloxy)phenyl]etanediamide N-[3-fluoro-4-((6-(methyloxy)-7-[(piperidin-4 147 ylnmothy1)oxy]quinolin-y1Joxy)pheny]-N-(2-oxo-2- A B B B B phenylethyl)ethaedamde N-(6-{ (6,7-bis(methyloxy)quinolin-4-yfloxy) -5 148 ohloropyridin-3-yl)-2,2-difluoro-N'-(4- C C fluorophenyl)propanediamide N-f 3-fluoroA4-[(6-(nrthyloxy)-7-{ [(1 149 methylpipeiidin-4yl)methyl]oxy~quinolin-4- A A A B A __ y1)oxy]pheny1-N'-phenyhmethyI)ethanediamide - N-[3-fluowo-4-({6-(methylaxy)-7-[(pipeddin-4 150 ylmethyl)oxylquinolin-4-yl}oxy)phenyl]-N-42-(2- A A A A A fluorophenyl)ethyllethaediamide N-[2-(3-chlowophenyl)ethyl]-N-(3-fluoro-4-({ & 151 (methyloxy)-7-[(pipedidin-4-ylmethyl)oxy]quinolin-4- A A A A A ylloxy)phenyl]ethanediamide N-[3-fluoro-4-(f6-(mothyloxy)-7-[(piperklin-4 152 ylmethyl)oxylquinolin-4-yl)oxy)phenyl-W-{2-[2- A A A A A (xnetbyloxy)phenyl]ethyl}ethanediamide N-[3-fluoro-4-(f6-(methyloxy)-7-(piperidin-4 153 ylmethyl)oxy]quinolin-4-ylloxy)phenyl]-N 1 -(2- A B B B pyiidin-3-ylethayl)ethanaeiamide-- N-[3-fluoro4(f 6-(mothyloxy)-7-[(piperidin-4 154 yhmethyl)oxy]quinolin-4-ylloxy)phonyll-N- A A A B A (phenybnethylethanediamide N-{2-[2,5-bis(methyloxy)phenyl]etliyl}-N-[3-fluoro 155 4-(f6-(methyloxy)-7-[(piperidin-4- A A A A A ylmethyl)oxylquinolin-4-yljoxy)phenyllethanediamide N4[3-fluoro-4-({6-(methyloxy)-7-[(piperidin-4 156 ylmethyl)oxylquinolin-4-yl~oxy)phonylj-N'-{2-[2- A A A A C (tfluoromethyl)phcnyljethyllethanedimide N-{2-[2.-(ethyloxy)phenyl]ethylj-N'-[3-fluoro-4-({ 6-. 157 (methyloxy)-7-[(pipeiidin-4-yknethyl)oxyjquinolin-4- A A A A A yl)oxy)phenyl]ethmnediamideI N-[-(2,4.-dimethylphenyl)ethyl]-N'-(3-fluoro 4-(16 158 (methyloxy)-7-[(piperidin-4-ylmethyI)oxylquoin-4- A B B A B3 yI }oxy)phenyl]ethanediamide N-[3-fluo4-({6-(methylocy)-7-[(piperidin-4 159 ylmethyl)oxyjquinolin-4-yIloxy)phenyl]-N'-[(15)-2- B3 C (4-methylphenyl)-1-phenylethyllethanediamide - - N-[2-(4-ohlorophenyl)ethyl]-N'-{3-fluoro-4-({& 160 (methyloxy)-7-[(pipeiidin-4-ylnethyl)oxylquinolin-4- A A A A B3 yI )oxy)phenyl]ethanedienuide 276 WO 2005/030140 PCTIUSZ004/031523 ({3-fluoca-4-[(6-(mcthyloxy)-7-{ [(1-methylpiperidin 161 4-y1)inethy1]oxy~quiolinA4- B C yI)oxylphcnyljainino)(oxo)acetc acid N-[3--luoro-4-({ 6-(methyloxy)-7-[(piperidin-4 162 yhnethyl)oxyjquinolin-4-y loxy)phnyl]-N'-2-(3- A A A fluorophenyl)ethyllctbaediamild- N-[2-(2-chlorophenyl)ethyl3-N'-[3-fluoro-4-({6 163 (mothyloxy)-7-[(pipcridin-4-ylmcthyl)oxylquinolin-4- A A A B A yl)oxy)phenyl]ethanediaxnidc N-[3-fluoro-4{{ 6-Qnethyloxy)-7-[(piperidin-4 164 ylmcthyl)oxylquinolin-4-yl}oxy)phenyl]-N'l-{2-[3- A A A A A (rnethyloxy)phenyl~ethyllethanediamide I N-(1,2-diphenylethyl)-N'-[3-fluoro-4-({6-(methyloxy)-: 165 7-[(piperidin-4-yhnethyl)oxylquinolin-4- A A B B C yl) oxy)phenyljethanediamide N-[2-(2 1 4-dlc-hlorophenyl)ethyl]-N'-[3-fluow-4-({ 6 166 (xnethyloxy)-7-[(piperidin-4-ylmethyl)oxy~quinolin-4- A B B A B ylloxy)phcnylethanedianide N-{2-[3,4-bis(methyloxy)phcnyllethylj-N'-[3-fluoro 167 4-({6-(mcthyloxy)-7-[Rpiperidin-4- A B B B __ylmethyl)oxyjquinolin-4-yI}oxy)phenyllethanediwideI I N-[2-(4--ethylphenyl)ethyl]-N-[3-fluoro-4-U6 168 (methyloxy)-7-[(pipcridin-4-ylmethyl)oxyjquinoin4- A B B B C yl}oxy)phenyllcthanediamide N-f 2-[4-(ethyloxy)phcnyl]ethyl}-N'P-[3-fluoro-4-Q6 169 (methyloxy)-7-[(pipcridin4-yhmcthy)oxylquinolin-4- B C B B yl}oxy)phenyllethanediwnidc e N-f 2-[4-(ethyloxy)-3-(methyloxy)phcnyllcthy }-N'-[3 170 fluoro-4-(f6-(mcthyloxy)-7-[(piperidin4 A B C B lyhmcthyloxylquinolin-4-yIloxy)phnyletandiamidc N-[3-fluoroA-(6-(methyoxy)-7-,(piperddin-4 171 yhmcthy1)oxylquinoin-4-y11oxy)phenyJ-NN-f2-4- B C C C I (phcnyloxy)phenyllecthyl )&hanediamidc 172 fluoro-4-({6-(methyloxy)-7-[Rpipzdin4 A C B B ylxnthyl)oxy]quinolin-4-yl )oxy)phcnylletbandiaxnide N-[3-fluoro-4-({6-(methyloxy)-7-[(pipeiidin-4 173 ylmctbyl)oxy]quinolin-4-yIloxy)phcnyl]-N'-(2- A A A B B I ~pyiidin-2-ylethylethanediamide N-[3-fluoro-4-({6-(methyloxy)-7-[(piperidin-4 174 ylxnethyfloxy]quinolin-4-yljoxy)phenylj-N-(2- A B B B C I pyridiu-4-ylethyl)ethanedianide N-13-tluoro-4-({6-(methyloxy)-7-R(piperidin-4 175 yhnethy1)oxylquinolin-4-y}oxy)phenyJ-NL-[2,(4- A A A A A fluropheuyl)ethyljethanediamide 277 WO 20051030140 PCTUS20O4/031523 N-(2-(2tromophenylethy]-NL-[3-fluoro-4-({6 176 (methyloxy)-7-I(piperidin-4-ylmthyl)oxy]quinoiw4- A A A A A ylloxy)phenyljethanediamide- - N-[2-(2-chloro-6-fluorophenyl)ethy3-N'-f3-fiuoro 177 ({6-(methyloxy)-7-[(piperidin-4- A A A B A ___ylmethyl)oxylcjuinolin-4-yl}oxy)phenyl]ethaedimide - - N-[3-fluoro-4-({6-(methiykncy)-7-[(pipedidin-4 178 ylmethyl)oxylquinolin-4-yljcrxy)phenyl]-N--[(2R)-2- A A A B A phenylpropyljethanediainide N-(2,3-dihydro-1H-inden-1-yl)-N'-[3-fluoro-4-({6 179 (methyoxy)-74[(ipefldinA-yhnothy1)oxy~quinolin4- A A A A A yl}oxy)phenyllethandiamide - N-f 3-fluoro-4-I(6-(methyloxy)-7-{ EU 180 methylpiperidin-4-yl)methylloxy}quinolin-4- A B B B __ yl)oxy]phenyl )-N' -(2-methylpropyl)ethanedimide __ N-{3-fluoro-4-[(6-(methyloxy)-7-{ [(1 181 methylpipeiidin-4-ylftnethyl]oxylquinoin4- A B B B B ___ yloxylphenylj-NL-(3-metbylbutyl)ehanedianide N-f 3-fluoro-4-((6-(niethyloxy)-7-{ [(I 182 methylpiperidin-4-yl)methylloxylquinolin-4- A A A A A yl)oxyjphenyl }-N'-[2R)-2 phenylpropyijothanediamide N-f 3-fluoro-4-[(6-(methyloxy)-7- {[(1 183 methylpipwridin-4-yl)methyl]oxylquinolln-4- A A A A A __yl)oxy~phenylj-N-(2-phenylpropyl)ethanediamide N-(2,3-dihydro-1H-inden-2-yl)-N-{3-fluoro-4-((6 184 (iethyloxy)-7-{[(1-methylpipetidin-4-A A A B A yl)methyl~oxylquinolin-4 y1)oxy]pbeny1}ethanedtamldr, N-[3-fluora-4-({6-(methyloxy)-7-[pipedldin-4 185 ylmethyl)oxy]quinolin-4-ylloxy)phenyl]-N-[(1R)-1- A B B B phenylethyl]ethanediamide N-[3-fluor-4-(6-(methyloxy)-7-(pipridin-4 186 ylmethyl)oxylquinolin-4-yljoxy)phenyl-N-R1IS)-1- A B A B C phenylethyl]ethanediamde N-[2-(3-bromophenylethy]-N'-[3-fluoro-4-({6 187 (methyloxy)-7-R(pipciidin-4-yhnetbyl)oxy]quinolin-4- A A A A A yl) oxy)phcnyllethanediamide N-[2-(2,6-diehlorophenyl)ethy3-N-[3-fluoro-4-({ 6 188 (naethyloxy)-7-[(piperidin-4-ylmethyl)oxylquinolin-4- A A A A A yl)oxy)phenyllethanediamide N4[2-(1,3-benzodioxol-5-yl)ethyl]-N'-[3-fluoro-4-({ & 189 (methylaxy)-7-[(piperidin-4-ylmethyl)oxyjquinolin-4- A A B A B yI Joxy)phenyljetnediamide 278 WO 2005/030140 PCTIUS2004/03 1523 N-f 5-cliloro-6-((6-(methiyloxy)-7-{ [(1 10 methylpiperidin-4-yl)mothylloxylquinolin-4- A A B A A 19 yJ)oxy~pyridin-3-y1)-N'-(4-fluorophenyl)c-yc-1propano I 1,1-dioarboxamide N- -3boa4(ehlxypeyl-ty)N-3 191 fluoro-4-({ 6-(methyloxy)-7-[(piperidin4- A A B B 13 ylmethyl)oxy]quinolin-4-yl }oxy)phenyljethandiamide, N-{2-[3,5-bis(methyloxy)phenyljethyl}-N'413-fluoro 192 4-(f{6-(methyloxy)-7-((piperidin-4- A, A A B B .ylmethyl)oxy]quinolin-4-yljoxy)phenyljethaediamide 13 N-[3-fluoro-4-(f 6-(me-thyloxy)-7-[(piperi#i-4- A 13 ylmethyloxylquinolin-4-yI~oxy)pheny1J-N'42-(2- A A A B A methylphiwyl)ethyljetbanediamide N-[3-fluoro-4-({ 6-(methyloxy)-7-[(piperidin-4 194 yhnethyl)oxy]quinolln-4-ylloxy)phenyl]-N'-[2-(3- A A A A A methylphe-nyl)ethyl]ethauediamide. N-f 2-[3-(ethyloxy)phenyllothyl}-N'-[3-fluoro-4-({6 195 (methyloxy)-7-[(piperidin-4-ylmethyl)oxylquinolin-4- A A B3 B B yl}oxy)phenyflethanediamide N-[2-(3,4-dimethylphenyl)ethyl]-N43-tluoro-4-({ 6 196 (meffiyoxy)-7-[(piperidin-4-ybmethy1)oxy]quinolln-4- A A B B B yl)oxy)phenyllethanedianide N- [2-(2,5-dimethylphenyl)ethy1J-N'-3-fluoro-4-({ 6 197 (methyloxy)-74[(ipeddin-4-ybmethy1)oxylquinoli-4- A A A AA yl}oxy)phenyllotamediamide N-f 2-[3.-chloro-4-(propyloxy)pheny1]ethy]1-N'-(3 198 fluoro-4-(f6-(metbyloxy)-7-[(pipeddinA- B C __ylmethyl)oxyjquinolin-4-yl }oxy)pbznyflothanediasnideI .N-f 2-f 4-(btutyLoxy)-3-chlorophenyllothyl)-N 1 -[3 199 fluoro-4-({ 6-(methyloxy)-7-[(Pipedidin-4- B c ylmethyl)oxylquinolin-4-yJ)oxy)phenyllctaneiaide - - - N-f 2-(4-(1,1-dimethylethyl)phenyllethyl)-N'-[3 200 fluoro-4-(f 6-(methyloxy)-7-[piperidin-4- B C ylme-thyl)oxyjquinolin-4-ylloxy)plicnyljethaediamide __ N-21-ai~ufnIPe~ltylN--loo4 201 (f6-(methyloxy)-7-[(pipezidin-4- A B B B B ylmethyl)oxy~quinolin-4-yl} oxy)phenyl]ethenedamide N-[3-ftuoro-4-(f6-(methyloxy)-7-[(piperidin-4 202 yluiethyl)oxy]qtuinoin-4-ylIoxy)phnylj-N'-( 244- A B B A B3 hydroxy-3-(methyloxy)phenyllethyl)ethenediamide N-[3-fluoro-4-(f6-(mcthyloxy)-7-[Rpiperidin-4 203 ylmthyl)oxylquinolin-4-ylloxy)phenyl]-N'-{2-[3- A B B B B3 hydroxy-4-(niethylox)XYPbcnyllethyl~ethanediamide - - - N-(2Z4-dkchlorophenyl)methyl]-N'-[3-fluoro-4-(f 6 204 (methyloxy)-7- [(pip eridin-4-ylniethyfloxy]quinolin-4- A A A A B I yI}oxy)phenyl~etbanedianuide 279 WO 2005/030140 PCT/U52004/031523 N-[3-fluoro-4-({6-(methyloxy)-7-[(pipeidin-4 2051 ylmeffiyl)oxyjquinolin-4-ylloxy)phenyl]-N-{ [4- A A B A A tluoro-2 __ (trifluoromothyl)phenyllmethyl }othanediamido e N-[3-fluoro-4-(f 6-(nwthyloxy)-7-[(piperklin-4 206 yhnethyl)oxy]quinon4-ylloxy)phenyl-N-[(1R)-1- A B B BB 207 ylietylox~qunoin4-y }xyph~1]Nr{ [- B B B Bj yl-methylqunln4)xyphenyl~eth ancdiema mide I- N-[3-fluoro-4-({6-(methyloxy)-7-[Rpiperidin-4 209 ylmethyl)oxy]quinolin-4-yloxy)phenyl]-N- (1)-- A B B3 3 B3 [(Ufurmethyl)phenyl]ethyleaeiam - N208-luow--(methyloxy)-7-[(pipeddin-4-A A A A B ntehlaphthuinln--ylthy hetb eanediaI 211 [3-fluoro-4-(6-(mtyloxy)-7-[(piperidin-4 A yl (methylqioi-loxy)phenyflethanediaxnide N-[3-flunro-4-({6-(methyloxy)-7-[(piperidin-4 212 ylmethyl)oxy]quinnhin-4-ylloxy)phenyl]-N'-[(1S)-1- A B C B (4-methylphnylethyl]ethaediamide 21 -[3-fluoro-4-((6-(methyloxy)-7-[(piparicin- A A A A A 23 ylmethyl)oxyquinolin4-yl}oxy)phenyl-hn'-( 6- B B N-[3-fluow-4-((6(methybxy)-7-[(pipridin4 214 yin ethy)oxYlquinlin4Y1)OXY)Pheny1]-N. [(2S-- A A A B (4nethylphenyl)ethyl]etbanediamide N-[3-fluoro-4-({6-(methyloxy)-7-[(pipedidin4 215 ylznethyl)oxy]quinolin-4-ylloxy)phenyfl]-N- [3- A A A B A inffuooetylpednyl 3eyljethhanediamide N-[3-fluoro-4-({6-(mthyloxy)-7-[(pipeidin-4 216 ylmethyl)oxylquinolin-4-yl joxy)phenyl-N-[42- A A B A A (tilotylphnylmethyl ehanediantde N-[3-dlorophenyl(methyl]xy--[3-fluorod-4-6 217 ( methyloxy[(iaiin-4-yheyl)oxy~unlln-4(- A A A A A yLecxylPhenylethlanediamide N- [3-fluaro-4-({6-(methyloxy)-7-[(piparidin4 218 ylmethyl)oxyquinlin4-yloxy)phenyl-N-[R- A B B BA ] __ ,24teturahyronphthalen-1-yljeothanedianiide __ N-[3,-dellophny~mthl]N'[3flo28016 WO 2005/030140 PCTIUS2004/031523 N-[3-fluoro-4-({6-(methyloxy)-7{(piperidin-4 219 ylmethy1)oxylquinoln-4-y)oxy)phny]-N -[(1S)- A A A A A 1,2,3A-tetrahydronaphthalen-1-yl]ethanediamide _ N-cyclopentYl-N'-[3-fluoro-4-({6-Qnethyloxy)-7 220 I pipeidin-4-ylmethyl)oxyjquinolin-4- A B B B B ylloxy)phonyl]ethanediamide N-(1-(4-bromophenyl)ethyl]-N'-[3-fluoro-4-({6 221 (metbyloxy)-7-[(pipeiidin-4-ylmethyl)oxyjquinolin-4- A B B B B3 yl }oxy)phenyl]ethauedlamide N-[3-fluoro-4-({6-(mcthyloxy)-7-[(piperidin-4 222 ylmcthyI)oxylquinoin-4-y1}oxy)pheny]-NL-[(2- A A B B A fluorophenyl)methyl]ethanediamide- - - - N-[2-(3,4-dchlorophenyl)ethyl-N'-[3-fluoro-4-({ 6- 223 (methyloxy)-7-[(piperidin-4-ylmethyl)oxyjquinolin-4- A A A A yl}oxy)phenyl]ethaediainide N-[3-fluoro-4-(f6j(methyloxy)-7-[(piperidin-4 224 y]methyl)oxy]quinolln-4-yljoxy)phenyl]-N'-(4- A A A A A fluorophenyl)methyl]etbanediainide N-[(2,3-difluorophenyl)methyll-N'-[3-fluoro-4-({6 225 (methyloxy)-7-[Rpiperidin-4-ylxnethyl)oxylquinolin-4- A A B B A i yljoxy)phenyllehianediamide N-[3-fluoim-4-({6-(methyloxy)-7-[(piperidiu-4 226 ylie~thyl)oxy]q'i-nolin-4-yl)oxy)phenyl]-N-[2- A A A A A (phenyloxy)ethyl]ethanedianiide N-(2,2-diphenylethyl)-N-[3-fluoro-4-({6-(methyloxy) 227 7-[(piperidin-4-ylmethyl)oxy]quiolin-4- A B B A B y1}oxy)phenyletbanediamide N-[3-fluoro-4(6me2IyIoxy)-7-fpiperidin-4 228 yhnethyl)oxylquinollnA-yljoxy)phenyl-N'-{2-[4- ;A B B B B3 (xnethyloxy)phenyllethyl }ethauediamidc N-[3-fluoro-4-({6-(methyloxy)-7-[(piperidin-4 229 ylmethyl)oxylquinolin-4-yljoxy)phenyl]-N-(2- A A A A A phenylpropyl)ethaediamide- - N-[2-(4-bromophenyl)ethyll-N-[3-fluoro-4-({6 230 (methyloxy)-7-[(piperklin-4-ylmethyl)oxylquinolinA- A A B B B yl)oxy)phenyl]ethanediamide N-(4-{ [7-{ [(1-ethylpipeiidin-4-yl)methyl]oxyj-6 231 (methyloxy)quinolin-4-yfloxy}-3-fluorophenyl)-2-oxo- A B B B B 2-(2-phenylmnorpholin-4-yl)acetamide N-[3-fluoro-4-({ 6-(methyloxy)-7-[(pipericlin-4 232 ylmethyl)oxylquiuolin-4-yl I}oxy)phenyll-N'-{ [3- A A B A B fluoro-5 (trifluoromethyl)phenyllmethyl~ethanediamide N-[(3,5-difluwropbenyl)methylJ-N'-[3-fluoro-4-(f 6 233 (methyloxy)-7-I(piperidin-4-yimethyl)oxy]quinolin-4- A A A B A yl }oxy)phenyllethanediawide 281 WO 2005/030140 PC F/USZOO4/03 523 234 [3-fluoro-4-({6-(metbyloxy)-7-[(piperidin-4- A A B A B 235 fluorophenyl)-MN(dimethylaniino)-2- B B B A phenyletbyl]ethanediamide, N-[3-fluoro-4-(16-(methyloxy)-7-[(pipermidin-4 236 yhnethyl)oxylqulnolin-4yl Ioxy)phenyl]-N-{ [4- A A A B B (methyloxy)phenyljinethyljetbanediamide N-[3-fluoro-4-(f6-(metbyloxy)-7-[(piperidin-4 237 ylmethyl)oxylquinoln-y1}oxy)pheny3-N-. [4- A B B B A __ (trifluoromethyl)phenyllmethyl}ethaediamide N-[3-fluoro-4-({6-(methyloxy)-7-[(piperidin-4 238 ylmetbhyl)oxylquinolin-4-yljoxy)phenyUl-N'-{ [3- A A A A B (methyloxy)pbenyljmethyl~ethanediamide N-[3-fluoro-4-({6-Qnethyloxy)-7-[(piperidin4 239 ylmethyl)oxy]quinoliu-4-ylloxy)phenyl]-N-f [3- A A A A B3 1_ (trifluoromethyl)phenyljmethyllethanediamide N-[3-fluoro-4-({6-(methyloxy)-7-[qpepridin-4 240 yhnethyl)oxylquinolin4-yIloxy)phenyl]-N-({3- A A A A A [E(trifluoromethyl)oxyjphenyllmethyl)ehaediemide N-[3-fluoro-4-({ 6-(methyloxy)-7-[(piperidin-4 241 ylmethyl)oxyjquinoliu-4-yIjoxy)phenyl]-N-f [2- A A A A A (methyloxy)pheny]methyl }ethanediamide- - - - N-[3-fluoro-4-(f6-(methyloxy)-7-[(piperidin-4 242 ylmethyl)oxylquinoln-4-yI }oxy)phenyl]-N'-{ [2- A A A A A (bifluoromethyl~pbeyl]Inthyljethanediamide N-[(3-ohlorophenyl)methyl]-N'-[3-fluor-4-(f 6 243 (mcthyloxy)-7-[(piperidin-4-ylmethyl)oxyjquinolin-4- A A A B B yl loxy)phenyl]ethanediamide N-[3-fluoro-4-({ 6-(methyloxy)-7-[(pipeiidin-4 24 ylmethyl)oxylquinolin-4-y I oxy)phenyl]-N!-({ 2- A A A A A [(tdifluoromrethyl)oxylphenyljnethyl)ethanediamide N-[(2-chlomophenyl)incthyfl-N'-[3-fluoro-4-({6 245 (mothyloxy)-7-[(piperidinA-ylmethyI)oxylquinolin-4- A A A A A yl }oxy)phenyljethanecliamide N-[3-fluoroA-({ 6-(methyloxy)-7-[(piperidin-4 246 ybnethyl)oxylquinolin-4-yllo~xy)pbeuyi]-N'-({4- A B B B B [(trifluoromethyL)oxyjphenyllmethyl)ethanediamide N-f 3-fluoro-4-[(6-(methyloxy)-7-{ [(I 247 mothylpiperidin-4-yl)methylloxylquinolin-4- A B A B yI)oxyjphenyl}-N'-f [4 (niethyloxy)phenyllrnethyl)ethanediaxnide N-f 3-fluoro-4-[(6-(inethyloxy)-7-f [(1 248 mehliedn4y~etylxlunln4 A B B B B3 yl)oxylphenyl )-N-f[4 (trifluoromethyl)phenyl]mothyl }effanedieniide 282 WO 2005/030140 PCT/1J52004/031523 N-QI4{ E7-[(azetidin-3-ylmc-thyl)oxy]-& 249 (methyloxy)quinolin-4-yl]oxy)-3-fluorophenyl)-N-(2- A A phenylethyl)ethanediamide N-(3-fluoro-4-{ [7-f JX-methylazctidin-3 250 yl)methyLloxy-6-(methyloxy)quinoln4- A A A A A __ ylloxy)phenyl)-N'-(2-phenylcthyl)cthanediamide N-[3-fluoroA4-({6-(mthyoxy)-7-[pipcdidin4 251 ylmethyl)oxy~quinolin-4-ylloxy)phenyl]-N'-(2- B B B B hydroxy-2-phe-nylethyl)ethanediaxnide N-(6-{ [6,7-bis(methyloxy)quinolin-4-ylloxyj -5 252 chloropyridin-3-yl)-N'-(24- A C difluorophenyl)propanedianiide N'-(6-{ [6,7-Wis(methyloxy)quinolin-4-yl]axy}-5 253 chloropyridin-3-yI)-N-(4-fluorophenyl)-N- B C inethylpropanediamide- - - N-[3-fluoro4-({6-(nrthyloxy)-7-(iperdin4 254 ylmethyl)oxylquinolin-4-yljoxy)phenyll-N'-(R)-1- A B B B B3 phenylpropyllethanediamide N-[3-fluoro4(6-(methyloxy)-7-[(pipeidin-4 255 ylmcthyl)oxy]quinolin-4yl~oxy)phnyl-N-[(1S)-1- A B C B pheuylpropyl~ethaneiamide N-[(3,4-difluorophenyl)methy]-IW-[3-fluoro-4({6 256 (znthyloxy)-7-[(pipedidin-4-ylmethyl)oxyjquinoln4 A A A B A yl~axy)phenyllethaediarnide 2,(mcthyloxy)-7-[(piperidin-4-ylmethy)oxy~quioin-4- A A A B A yl }oxy)phcnyl]cthanediamide N-f 3-fluoro-4[(6-(mthyloxy)-7-{ [(1 258 methylPIPrlin-4-yl)methylloxy~qunoln-4- A A A A A yl)axyjphenyl)-N'-[2-$4 fluorOPhenyl)cthyllethanediamidc N-f 3-fluoro-4-[(6-(methylaxy)-7-f [(1 259 mthylpiperidin-4-yl)methyl]oxy)quinoin-4- A B C C B yl)oxylphenyl}-N-phenylcthianedianice- - - - N-[3-fluoro-4-({6-(methyloxy)-7-[Rpiporidin-4 260 ylmcthyl)oxyjquinolin-4-yljoxy)phenyl]-N-(3- A C B C C 261 (methyloxy-7ropperidn-yb~nethyioxqinoi--A e N-3-bisormethyloxyophenyl]-N'-[3-fluoro-4-({6 262 (methyloxy)-7-[(Piperidin-4-yhnethyl)oxylqinoin-4- A C C B -1 yJ~oxy)phenyljethanediamide N-[3-fluoro-4-(f 6-(methyloxy)7-(piparidin-4 263 ylmethyl)ox-ylquinolin-4-yloxy)phenyl]-W-(3- A B A B B methylbutyl)ethanediamide 283 WO 2005/030140 PCTIUS2004/03152 N-(3,3-dimethylbutyl)-N'-[3-fluaom4-((6-(nethyloxy) 264 7-[(piperidin4-ylmethiyl)oxy]quinolin4- A A A A B ylloxy)phenyllethanediamide N-[5-ohor-6-({6-(methyloxy)-7-[(3-piperidin-1 2651 yl]oy~xjunh4ylx~yii--l--4 A B B A B fluorophenyl)propanediamide N-[5-chloro-6-({ 6-(wethyloxy)-7-[(3-mcqphoin-4 2661 ylpropyl)oxylquinolin-4-ylloxy)pyridin-3-yl]-N'-(4- A B B A B flucrophenyl)propanedienide N-(5-obloro-6- {[7-{ [3- (diethylamino)propyl]oxy}-6 267 (methyloxy)quinolin4ylloxypyridin-3-yl)-N'-(4- A B B A B tluarophenyl)propanediaunide N-[(4-ohlorophonyl)methyl]-N'-[3-fluoro4-({6 268 (methiyloxy)-7-[(piperidin-4-ylmethyl)oxylquinolinA- A A yl )oxy)phenyl]ethandiamide N-{ [3,5-bis(methyloxy)phenyllmothyl}-N'-[3-fluoro-4 269 (f{6-(niethyloxy)-7-[(piperidin-4- A A A __ylmethyl)oxy]quinolin-4-yl }oxy)phcnyl]cthaediamicle N-[(4-butylphenyl)methyl]-N-[3-flnoro-4-({ 6 270 (methyloxy)-7-[(piperidin-4-ylmethyl)oxy]quinolinA4- A B B B B ylloxy)phenyljethaediamide N-[3-fluoro-4-({ 6-(methyloxy)-7-[(pipedidin-4 271 ylmethyl)oxylquinoin-4ylloxy)phnyl]-N-[2-(4- A B B A B methylphenyl)ethyl]ethanediomide N-{ [3,5-bigtrifluoromethyl)phenyllniethyl}-N-[3 272 fluoro-4-({6-(xnethyloxy)-7-[(piperidin4- A A C B ylmcthyl)oxy]quinolin-4-yI )oxy)phenyl]ethmnediaznide N-[3-fluoro-4-({6-(methylnxy)-7-[piperidin4 273 ylmcthyI)oxylqufnoli-4-y1}oxy)pheny]-N- pymzin- B C C B 2-yhnacthyl)othaneduanii-A N-[3-fluoro-4-({&(methyloxy)-7-[Rpipeiln-4 274 ybmethy)oxyquinolin-4-y1}oxy)oheny1]-N'-(pyridin- A B B B B 2-ylnaethyl)ethaediamide N-[3-fluoro-4-({ 6-(methyloxy)-7-[Rpiperidin-4 275 ylmthyl)oxylquinazolin-4-ylloxy)phenyl]-N'- (2- A A A A A phenyletbyl)ethanediamide N-{ 3-fluoro-4-[(6-(methyloxy)-7-{ [(1 276 methylpiporidin-4--yI)methyl]oxy}quinazolin-4- A A A A A yl)oxylphenyl J-N'-(2-phenylethyl)ethanedimniide N-[3-fluoro4-({ 6-(methyloxy)-7-[(piperidin-4 277 ylmethyl)oxylquinolin-4-yljoxy)phenyfl-N- [ 2 A A A A A fluoro-3 (trifluoromthyflphenyljmethyflethanedianide N-{2-[2-bromo-6-(methyloxy)phenyl]ethyl}-N-[3 278 fluoro-4-((6-(methyloxy)-7-[(piperidin-4- A A A A A yhncthyl)oxylquinolin-4-yl )oxy)phenyl]ethanediamde 284 WO 20051030140 PCTfJS20O4/031523 IN-f 2-[3,4-bis(mcthylox~y)phenylje-thyl }-N'-[3-fluoro 2791 4 -(16-(methyloxy)-7-[(pipeidin4-B B B A 1 ylmthyl)oxylquinolin-4-yl)oxy)phenty]-N- B B B A B z-methylethanediamide I I I 280 fluoro-4-(16-(metbyloxy)-7-[(piperidin-4- A A A A A __ylmethyl)oxy]quinolin-4--yl}oxy)phenyl]ethancdlwnide N-[3-flluoro-4-(f 6-(incthyloxy)-7-[(piperiti-4 281 Yltyl1 7xylqwnoiny}oxypey]-N-{( (Z A A 13 A 13 fluoro-5 (tifluoromethyl)phenyl]methyl}ethaediamide N-[5-cbloro-6-({6-(methyloxy)-7-['piperidin-4 282 yh thyl)oxylquinolin-4-yl~oxy)pyrklin-3-yl]-N-(4- A A A A A tiorphvnyfrcycloprpan-1,1-d&carboxamide N-[3-fluoro-4-({6-(methyloxy)-7-[(piperidin-4 283 ylmethy])oxylquinolin-4-y1}oxy)phenyI]-N-[1-(4- A A B A B3 fluoropheriyl)ethyl]ethanediamide N4[3-fluoro-4-(f6-(methyloxy)-7-(iperidin-4 284 ybmetbyloxy~quinoin4-y}oxy~pheny1]-N'4(1S)-2- A C B B C oxo- 1-f peylnthyl)-2-pyrrolidin-l ylethyl]ethanediamideIIh N-f 3-fluoro-4-[(6-(methyloxy)-7-f [(3aR,6a5) 285 ~octahydrocyclopenta[c]pyrrol-5-A A A A A 2~5 ylmethyljoxyjquinazolin-4-yl)oxylphenyl}-N'-(2 A A A phenylethyl)ethaedianaide N-[2-(4-aminopheny)ethy1]-N'-[3-fluoro-4-(16 286 (niethyloxy)-7-[(pipeiidin-4-ylmethyl)oxylquinolin-4- A B B B B ylloxy)phenyllethaecliamide N-[3-fluro4Q 6-(methyloxy)-7-[(piperdin4 287 ybnethyl)oxy]qulnoin-4-yljoxy)phcnylj-2-oxo-2-[4 A A B A B (phenyhmethy1)pipeiidin- l-yflacetamidc 28 N-(4-{ [6,7-bis(incthyloxy)quinolin-4-yl]oxy'phenyl)- A A A A A N!-(4fluoropheny)propanediamideI 1 29N-(4-f [6,7-bis~methyloxyquinolin4-yI]oxylphenyI)- A - - .8 29N'-%4fluoropheny4~cyclopropane-1,1-dioarboxamideA A .5 N-(6-{ [6,7-bis(methyloxy)quinolin-4-yJ]oxy}-5 290 chloropyridin-3-yI)-N'-(3- B C fluorophenyl)propanediamide 291 N-(6-f[6,7-bis(methyloxy)quinohin-4-y]oxcy)-5- A C B A C cliloropyridin-3-yl)-N'-phenylproponediamide N-(6-f [6,7-bis(metbyloxy)quinolin-4-y~oxy}-5 292 r-lrprdn3y)N-4furpoy)22 B B B A B3 dimethyipropanecliamide N-ethyl-N'-t3-fluoro-4-Q 6-(methyloxy)-7-[(pipcridin 293 4-ylmethyl)oxy]quinolin-4- A B B B B3 yl }oxy)phenyl]etbanediamide 285 WO 2005/030140 PC F/USZOO4/031523 N-(3-fluoro4-C(6-(methyloxy)-7-(piperidin-4 294 ylnethy)oxyquinolin-4-ylloxy)phenyl]-N'-(1- A B B B C methylethyl)ctbanediamide N-uy-'[-loo4( -(ehlx)7[pprdn 295 4-yimetbyl)oxyjquinolin-4- A B B B B yljoxy)phenyl]ethanediamide N-[3-fluoroA4-({6-(mothyloxy)-7-[ftiperidin-4 296 ylmethyi)oxylqui-nolin-4-y}oxy)phonyl-N'-[2- B B B B C (mcthyloxy)ethyljethanediemidec N-(cyclopropyhnethy)-N-[3-fluoro-4{{6 297 (methyloxy)-1-[(pipoildin-4-ylmethyl)oxy]quinolin-4- A B B B B yl }oxy)phenylfrthanediamfide N-[3-fluoro-4-({ 6-(methyloxy)-7-((piperidin-4 298 ybnethy1)oxy~quinolin-4-yI}oxy)phcnyl]-N'-(2- B A B A B morpholin-4-ylethyl)ethanediawidr, N-[3.-fluoroA4-({6-(niethyloxy)-7-[(piperidin-4 299 ylmethyl)oxyjquinoin-4-yl)oxy)phnyl-2-oxo-2- A B B B B pylrolidmn-1-ylacetamide N-othyl-N'-[3-fluoro-4-({6-(methyloxy)-1-((piperidin-: 300 4-ylmothyl)oxyjquinolin-4ylloxy)phenyl] -N- A B C B B methylethanediamide N-(6-( [6,7-bis~nethyloxy)quinolin-4-yljoxy}-5 301 cliloropyridin-3-yl)-N-(pbcnyimethyl)oyclopropane- A C B B B 1, 1-dicarboxamido. N-(6-{ [6,7-bis(methyloxy)quinolinA-yl]oxy)-5 302 ohloropyiidin-3-yl)-N'-(2-phenylethyl)oyolopropane- C C 1, 1-dicarboxamide SN-{4-[(7-ohloroquinobn-4-yl)oxy]-3-fluorophcnyl}- A A C C B 33N'-%4fluorophnyl~oyclopropane-1,1-divurboxamide A C C N-(4-{ (7-f [2-(diethylainino)ethyloxy}-6 304 (mothyloxy)quinolin-4yloxy-3-fluomphenyl)-N-1- A A A A A fluorophenyl)oyclopropane-1,1-dfoarboxamide N-(6- { 6,7-bis(meffiyloxy)quinolin-4-ylloxy}-5 305 chloropyridin-3-yl)-N-phenylcyolopropane-1,1- A B B A dicarboxamide N-(6-{ [6,7-bis(metbyloxy)quinolin-4-yI]oxy}-2 306 methylpyriclin-3-yl)-N'-(4-fluorophenyl)cyclopropane- A B B C B 1,1-dicarboxaniide N-(4- ([7- {[2-(diothylamino)ethylloxy}-6 307 (methyloxy)quinolin-4-yIloxy)-3-fluorophenyl)-N'- (4- A A A B A fluorophenyl)oyolobutane-I,1-dioarboxamide1 308 N-{4-[(7-chloroquinoin-4-yl)oxy]phcny}-N-(4- A A B C B fluorophenyl)cyclopropane- 1,1-dioarboxamide N-[5-vhkiro-6-({6-(methyloxy)-7 309 [(phonylnithyl)oxyquinoln4yljoxy)pyridin-3-yl]- A C C B C N'-(4-fluorophenyl)oyclopropane-1,1-dicarboxamide 286 WO 20051030140 PCT/J52004Il31523 N-(4-( E6,7-bis(methy4oxy)quinawlin-4 310 yloxyjphenyl)-N'-(4-fluorophenyl)oyclopropane-1,1- A A A A A F dicarboxanide N-(4-{16,7-bis(methiyloxy)quinazolln-4-ylloxy)-3 311 fluorophcny)-NL(4-fluoropheny1)cyolopropane- 1, 1- A A IB A A dicarboxamide N-[3-fluoro-4-((6-(Inethyloxy)-7-[(3-moipholin-4 3121 ylpropyl)oxy]quinolin-4-yIloxy)phenyl]-N-(4- A A A A A fluorophenyl)oyclopropane-1,1-dicarboxamide N-[3-tluoro-4-(f6-Qnothyloxy)-7-[(3-piporidi-1 313 ylpropyl)oxylquinolin-4yl)oxy)phenyl]-'-(4- A A A A A fluorophenyl)cyclopropane-1, 1-dioarboxamide I N-[3-fluoro-4-(f 6-(methiyloxy)-7-[(3-pipo~ridin-1 314 ylpropyl)oxyjquinolin-4-yl)oxy)phenyl]-N-(4- A A A B A __ fluorophenyl)oyclobutane-1, 1-diHcarboxamicle - - - N-[3-fluoro-4-Q(6-(methyloxy)-7-[(3-Torpholin-4 315 ylpropyl)oxy]quinazolin-4-yljoxy)phenyl]-N-(4- A A A A A fluoropheyl)oydopropauc-1,1-dioaboxmide N-{3-fluoro-4-[(6-(methyloxy)-7-f [(1 316 methylPipeidin-4-y)mehyloxylqunazlin-4- A A A yl)oxy]phenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-A A A A A clicarboxamide N-(4- {[6,7-bis~nethyloxy)quinolin-4-ylloxy}-2 317 mctbylphenyl)-N'-(4-fluorophenyl)oyolopropane-1,1- A A A C A dicarboxamide N-(4-fluorophenyl)-N-[2-methyl-6-Q 6-(methyloxy)-7 318 [3-morpholin-4--ylpropylyquinoMi-4- A A B B B __ yl oxy)pyridin-3-yllcyclopropane-1, 1-dicarboxamde N-(4-{[6,7-bis(methyloxy)quinolin-4-yfloxy}-3 319 fluorophenyl)-N'-(4-fluomophenyl)oyclopropane-1,1- A A A A A dicarboxamide N-(6-{ [6,1-bis(methyloxy)quinolin-4-yI]oxy}-5 320 cloro-2-methylpyiidin-3-yl)-N t -(4- A C C B C fluorophenyl)oyclopropane-1, 1-dicarboxam~idea N-f-fluoro-4-( 7-(methyloxy)-6-[(3-morpholin-4 321 yirployqiaoi--loypey]N-4 A A B A A fluoropbenyl)oyclopropanc-1, 1-dicarboxamide N-[3-fluoro-4-({7-(methyloxy)-6-[(3-morpaolin-4 322 ylpropyl)oxy]quinolin-4-ylloxy)phnyl--N-(4- A A A A A fluorophenyl)cyclopropane-t1-carboxamide - - N-(4-( [6,7-bis~nethyloxy)quinolin4-yl]oxy}-3,5 323 difluoropbenyl)-N'-(4-fluorophenyl)oyolopropane-1,1- A A B A A dicarboxamide N-(4- {[6,7-bis(methyloxy)quinoin4yl]oxy}-2,5 324 ditluorophenyl)-N-(4-fluorophenyl)vyolopropane-1,1- A A A A A dicarboxanide 287 WO 20051030140 PCTIIJS2004/031523 N-(3-fluoro-4-[(7-Qnethyloxy)-6-{ [(1 35 methylpiperidin-4-yl)methyljoxyjquinazo~n4.- A A 35yfloxylphenyll-N'-(4-fluorophenyl)cyclopropnne-l,l- A A B. dicarboxamide N- [5-fluoro-2-methyl-4-({6-(methyloxy)-7-{(3 326 morpholln-4-ylpropyl)oxy]quinolin-4-yIloxy)phenylj- A A B B B __ I-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide I_ N-(4-{ [6,7-bis(metbyloxy)quinolin-4-yI]oxy)-2,3,5 327 tzifluorophcnyl)-N'-(4-fluorophcuyl)cyclopropane-1,1- A A B B B dicarboxamide N-(4-f [6,7-bis(niethyloxy)quinolin-4-yl~oxy) -5 328 fluoro-2-methylpheny)-NL(4- A B B C C quorophenyl)rcyclopropane-1,1-dicarboxanaidc N-(4-f [6,7-bis(methyloxy)quinolin-4-yJ oxy) -2 329 cbloro-5-methylphenyl)-N'-(4- A B B C B3 tfluorophonyl)cyclopropane-1,1-dicarboxamide N-(3-fluoro-;4-{ [6-hydroxy-7-(methyloxy)quinolin-4 330 yIloxylphenyl)-N-(4-fluorophenyl)cyclopropane-1,1- A A A A A dicarboxamide N-(4--fluorophenyl)-N'-[2-methyl-4-({ 6-(methyloxy)-7 331 [(3-mnorphoiin-4-ylpropyl)oxylquinolin-4- A A A B A yl }oxy)phenyllcyclopropane-1,1-dicarboxamide N-[3-fluoro-4--({6-(methyloxy)-7-[(3-piperzn-1 332 ylpxopyl)oxy]quiuolin-4-yJloxy)phenylj-N'-(4- A A A A A fluorophenyl)cyclopropane-1,1-dicarboxamd N-{ 3-fiuoro-4-[(6-(metbyloxy)-7-{ [3-(4 33methylplpmazlfl-1-y)pwopyl]oxylquulhn-4 yl)oxylphcuyl}-N'-(4-fluorophenyl)cyclopropane- 1,1-A A A A A dicarboxainide N-f 3-fluoro-4-ff6-Qnethyloxy)-7-{ [(1 334 methylpiperidin-4-yl)mthyl]oxyquinolin4 A A A A A yI)oxy]phcnyl )-N-(4-fluorophcnyl)cyclopropano- 1,1 dicarboxamide N-(4-tluoropbcnyl)-N'- [4-({ 6-(mcthyloxy)-7- [(3 335 morpholin-4-ylpropyl)oxy]quinolin-4- A A 'A A A yl Joxy)pbenylloyclopropa-ne-1,1-dlarboxamdc N-(4-f [7-f [3-(cliethylamiao)propyfloxy)-6 336 (methyloxy)quinoliu-4-yl]oxy)-3-flurophenyl-N(4- A A A A A fluorophcnyl)cyclopropmne-1, 1-dlcarboxamide - - - N-(4-f [6,7-bie(mthyloxy)qubaolin4yl~oxy)-2 337 chloro-5-fluorophcnyl)-N'-(4- A B B C C ___ fluorophenyl)cyclopropane-1, 1-dicarboxamide I N-(4-{ [6,7-bis(methyloxy)-2-(methylthio)quinolin-4 338 ylloxy)-3-fluorophenyl)-N-(4 fluorophonyl)cyclopropano-1, 1-dicarboxamideJ 288 WO 2005/030140 PCT/US2004/031523 N-4fuoohnl N(-[2-methyl-6,7 3391 bis(methyloxy)quinazolin4- C C ylloxylphenyl)cyclopropane.1,1-dicarboxamide N-{4-{ [2-amino-6,7-bis(mtyloxy)qtdnoin4 340 y1Joxy}-3-fluoropbeny1)-N-(4- C C ___ fluoropbenyl)cyclopropane-I,1-dicarboxamide N-(3-fluoro-4-{[2-(mthylamno)-6,7 341 bis~metbyloxy)quinolin-4.yl]oxylphenyl)-Nt.(4- C C fluorophenyl)cyclopropane-1,1-dfioarboxawide (1S,2Rj-N-[3-fluoro-4-({6-(xuethyloxy)-7-[(3 342 maorphoin-4-ylpropyl)oxylquuoln-4-yloxy)phenyl]- A A B A A N'-(4-tluomaphenyl)-2-methylcyclopropmne-1, 1 dicarboxamide (1R2R)-N-[3-fluoro-4-({ 6-(motltyloxy)-7- [(3 343 morpholin-4ylpropyl)oxyquinolin-4-yljoxy)plienyl]- A A A A A N'-(4-fluorophenyl)-2-methylcyclopropane-t 1 dicarboxamide N-(4-{ [6-f [3-(diethylamino)propytloxy)-7 344 (mthyloxy)quinoiin-4-ylloxy)-3-fluorophenyl)-NM4- A A A __ fluorophenyl)cyclopropane-1, 1-dicarboxamide - N-(4-{ (6-f [2-(dicthylamino)ethylloxy}-7 345 (methyloxy)quinolin-4-ylloxy}-3-fluophenyl)-N'-(4- A A A tluowophenyl)cyolopropane-1,1-dioarboxamide - - 1, 1-dhncthykethyl 4-(3- f [4+[2-fluoro-4-{ [(1-{ [(4 36fluorophcnyl)amino]carbanyl)cycloprapyl)cabonyljaA AB 34 nmno }phenyl)oxy)-6-(methyloxy)quinolin-7- A AB ylloxylpropyl)piperazine-I-carboxylate (UI2R)-N-[3-tluoro-4-({ 6-Qnethyloxy)-7-[(3 347 morpholin-4-ylpropyl)oxy]quinazolin-4- A A yljoxy)phenyl]-NL-(4-fluorophenyl)-2 methylcyclopropaue- 1, 1-dicarboamide - (1R,2R)-N-(4-{ [7-{ [2-(dicthylamino)ethyl~oxy}-6 348 (inethyloxy)quinazolin-4-yl]oxy}-3-fluorophenyl)-N'- A A B (4-fluowophenyl)-2-metbhyloyclopivpae-1, 1 dicarboxamide N-(4-{ [7-f [3-(dlethylamino)propylloxy)-6 349 (methyloxy)quinazolin-4ylloxy)-3-fluorophenyl)-N'- A A A (4-fluorophcnyl)cyclopropane-1, 1-dioarboxamide N-(4-f (7-f([3-(4.-acetylpiperazin-1-yl)propyl]axy}-6 350 (niethyloxy)quinoiin-4.yl~oxy}-3-fluorophenyl)-N'-(4- A A A fluoropbnyl)cyclopropane-1,1-dicarboxamide 1,1-dimethylethyl 4-(3-{ [4-[(2-fluoro-4-{ [((IR,2R)-1 { [(4-fluorophenyl)aminolcaxbonyl }-2 351 inethylcycloprapyl)carbonyl~aminoflpheuyl)oxy]-6- A A B (methyloxy)quinolin-7-yljoxylpropyl)piperazine-1 carboxylate 289 WO 20051030140 PCTIUS2004/031523 N-(4-{ [ 6 ,7-bis(methyloxy)quinolin4-yl~oxy~phenyl) 352 N'-(4-fluorophonyl)-1-(phenylmethyl)azeddine-3,3- A C C dicarboxamide 33N-(4-( [6,7-bis(methyloxy)quindlin-4-yljoxylphenyl)- B cC __ N'- @-fluorophenyl)azeticline-3,3-dicarboxanmide - - (1R,2S)-14-{ 3-fluoro4[(6-(methyloxy)-7-{ [3-(4 354 methylpiperazin-l-yl)propyloxylqumnolin-4- A A A yl)oxylpheuyl)-N'-(4-fluorophenyl)-2 methiylcyclopropane-1 ,1-dicaxboxamide (IR,2R)-N-{3-fluoro-4[(6-(mthyloxy)-7-{ [3-(4 355 Irthylpiperazin-lyl)propylloxyjqrnnohinA4 A A A yl)oxyjphenylj-N t -(4-fluorophenyl)-2 methylcyclopropane- 1, -dicarboxamide (1R,2R)-N-[3-fluoro-4-({6-(methyloxy)-7-[(3 356 piperazin-1-ylpropyl)oxylquinolin-4-yl }oxy)phenyl]- A A A IW-(4-f lu owphenyl)-2-xnethiylryclopropane- 1,1 dicarboxamidr, N-(3-fluoro-4-f [7- ((3-[4-(1-methylethyl)piperazin-1 357 yl]propyljoxy)-6-(methyloxy)quinolin-4-A AA yl]oxylphenyl)-N'-(4-tlnorophenyl)cycbopropane-1,1-A AA clicarboxamide N-(4-{ [7-f [3-(diethylamino)propyfloxy}-6 358 (methyloxy)quiniazolin-4-yl]oxy}-3-fluorophenyl)-N'- A A A __ (4-fluorophenyl)oyclopropane-l, I-dicarboxaznide (IR,2R)-N-(4-{ [7-f [3-(diethylamnino)propylloxy}-6 359 (methyloxy)quinolin-4-ylloxyj-3-fluorophenyl)-N'-(4- A A A fluorophenyl)-2-mnethylcyclopropane- 1, 1 dicarboxamide (1R,2R)-N-(4- ( [7-f [2-(diethylamino)ethyl]o-xy}-6 360 (methyloxy)quinohn4-ylaxy-3furpenyl)-N (- A A A fluoxophenyl)-2-methylcylopropane- ,1I dicarbaxanide (IR,2S)-N-(4-{ [7-{ [3L-(diethybamino)propy1]oxy}-6 361 (methyloxy)quinoli-4-yl]axy}-3-fluorophenyl)-N'-(4- A A A fluorophenyl)-2-methylcyclopropane-1, 1 dicarboxamide (IR,2S)-N-(4-{ [7-{ [2-(diethylamino)ethyl]oxy}-6 362 (mcthyloxy)quinolin-4-yl]oxy}-3-fluoraphenyl)-N'-(4- A A A fluorophenyfl-2-mothylcyclopropane- 1,1 dicarboxamide N-(4-{ [7-f [2-(diethylanino)e-thylloxy} -6 363 (inethyloxy)quinazolin-4-yljoxy} -3-fluaropheny)-N- A A __ (4-fluorophenyl)cyolobutane-1,1-dioarboxatnide (1R,28)-N-[3-fluaro-4-({ 6-(methyloxy)-7-[(3 364 pipcrazin-1-ylpropyl)oxy]quinolin-4-yfloxy)phanyl]- A A A N'-(4-fluorophenyl)-2-methylcyclopropane-1 dicarboxamide 290 WO 2005/030140 PCT/TJSZOO4/031523 (1TR. 35)-N-[3-fluora-4-({6-(methyloxy)-7-[(3 365 morPhalin-4-ylpropyl)axylquinain4-yl}axy)phenyl]- A B B R-(4-fluarophenyl)-2,3-dimethyloyclopropane- 141 dicarbaxamide (lr,2R,35)-N-{3-fluoro-4-[(6-(methyloxy)-7-{ [3-(4 36 mcthylpiperazin-1-yl)propylloxylquinalin-4- A B B yl)oxy]phenyl}-N'-(4-fluorophenyl)-2,.3 dinathylcyclopropane-1, 1-dicarboxawide (lr,2R,35)-N-[3-fluaro-4-(f6-(mcthylaxY)-7-1(3 367 morphoin-4-ylpropyl)oxyjquinazoin-4- B A B yljjaxy)phenyl]-N-(4-fluoroDphenyl)-2,3 dinethylcyclapropane-1,1-dicarbaxamide I (k,2R,35)-N-{ 3-fluoro-4-[(6-(methyloxy)-7- {[3-(4 368 methylpiperozin-1-yl)propyl]axyyquinazalin-4- A A B yl)axy]phenylj-NM4-fluorphenyl)-2,3 dimnethykeyclapropane-1, 1-dicarbaxamide N4[3-fluoro-4-([6-(metbylaxy)-7-[(3-morpholin-4 369 ylpropyl)oxylquinazalin4-yl~pxy)phenyl]-N'-(4- B3 A B fluorophenyl)cyclobutae-,l-dicatbaamide (ZR,3R)-N-[3-fluoro-4-({ 6-Qnothylaxy)-7-[(3 370 m lholii-4-yLpropyl)oxy] uno-4-y}axy)phony1]- A A B N (-loohnl-,-dmtycco~oae 1, 1 dicarboxamide (ZR-,3R)-N-(4-{ [7-f [3-(diethylamina)propyl]oxy}-6 371 (methyloxy)quinolln-4I-ylloxy}-3-fluoraphenyl)-N'-(4- A A B fluorophenyl)-2,3-dimethylcyclopropane-I,t dlicarboamide N-(4-{ [7-f [3-(dithylamina)prapyllaxy}-6 312 (nzethyloxy)quinain-4-yl]axy) -3-flu&rohon$)-N'-(4- A A B fluarophenyl)-2,2-dimethykcycloprapane-1, 1 dicarboaoide N-[3-fluoro-4-({6&(methyloxy)-7-[(3-morphlin-4 373 ylpropyl)oxy]quinazolin-4yllaxy)phenyl-N-(4- A A C fluarapheny-2,2-dimethylcyclopropane-1, 1 dicarbaxamide (lr,2R,3S)-N-(4-{ [7-f [3-(diethylamino)prapyllaxy}-6 374 (methyloxy)quinolin-4-ylloxy)-3-fluoropbenyl)-N'-(4- A B B fluorophenyl)-2,3-dimethylcyclopropane- 1,1 dicarbaxamide N-(4-f [7- (12-(diethylamino)ethylloxyl-6 375 (methyloxy)quinalin-4--ylloxy}-3-fkioraphenyl)-N'-(4- A A C fluoraphenyl)-2,2-dbethylcyclapropane-1,t dicarbaxauzidde (lr,2R,35)-N-(4-{ (7-{ [2- (diethylaniino)ethyllaxyl-6 376 (niethyloxy)quinalin-4-yl]axy) -3-fluorophenyl)-N'-(4- A B B fluoraphenyl)-2,3-dixntbylcyclapropane-1, 1 clicarboxamide. 291 WO 20 051030140 PCTIUJS2004/031523 -N-[3-fluoro-4--(16-Qnethyloxy)-7-[(3-morpholin-4 377 ylpropyl)oxylquiuoin-4-yI}oxy)phenylJ-N'-(4- A A B fiuoraphenyl)-2,2-dmethyloyclopropane-1, 1 dlicarboxamide N-04-{[7-f [2-(cliethylamnino)ethylloxyl-6 378 (nwhlx~unzln4y~xl3fumhnl-' A B c (4-fluorophenyl)-2,2-dimethylcyclopropano -1,1 dicarboxamido N-(4-f1[7-4 [3-(diethylamino)propyljoxy)-6 379 (methyloxy)quinazo]in-4-yljoxy}-3-fluoropheny])-N'- A A c (4-fluoruphenyl)-2,2-dinothylcyolopropane-1 ,1 I dicarboxamide N-(4-f [7-f [3-(cliethylzilno)propyl]oxy}-6 380 (metbyloxy)quinezolin-4-yljoxy) -3-fluorophenyl)-N'- A A B (4-fluorophenyl)cyclobutane-1,1-dicarboxaaiide N-{3-fluoro j(&(mthyloxy)-7-( P3-(4 381 methylpiperazin- 1-yl)propyl~oxylquinazolin-4- A AB yL)oxy]phoenyl}-N'-(4-fluorophenyl)cyclobrutane-1,1- A AB i d~cicarboxamideII N-[3-fluoro-4.<{f6-(methyloxy)-7-t(3-piperazin-1 382 ylpropyl)oxy]quinazolin-4ylloxy)phenyl-N-(4- A A B fluorophcnyl)cyclobutane-1,1-dicarboxmide (2R,3R)-N-[3-fluoro-4-({ 6-(methyloxy)-7-[(3 383 m-4h~--ypopyl)ox1qiazolii4- A A yfloxy)phenyl-N 1 -(4-fluoropbenyl)-2,3 dimetbylcyrclypropane-1,1-dicarboxamide N-(4-f [7-4 [3-(diethylamino)propylloxy)-6 384 (nrthyloxy)quinolin-4-yloxy-3-fluorophenyl)-N-(4- A AC fluorophenyl)cyclobutanc- 1, 1-dicarboxamide - - - N-{3-fluoro-4-f(6-Qnethyloxy)-7-f [3-(4 385 y olpio e$;= 1 -yroyloy tun li A A dicarboxannde (VR,2R)-N-(4-f [7-f [3-(dlethylamino)propylloxy}-6 386 (nfilx~unzln4yloy--loohnI-' A A A (4-fluorophenyl)-2-nethylcyclopropane-1, 1 clicarboxainide (1R,2k)-N-4 3-fluoro-4-[(6-(methyloxy)-7-{ [3-(4 387 nothyP flr'-1-yl)Pwopyl]oxylqtlflazo~il4- A A A yl)oxylphenyl}-W-(4-fluorophenyl)-2 methylcyclopropane-1, 1-dicarboxeinide (2R,3R)-N-(4-{ [7-f [2-(dllethylamino)ethyl]oxy}-6 388 (mnethyloxy)quinazolin-4-yloxy)-3-fluorophenyI)-N- B A C (4-fluoropbenyl)-2,3-dimethylcyclopropane -1, 1 dicarboxanide 292 WO 2005/030140 PCTIU20104/031523 (2R,3R)-N-(4-{1:7-f [3-(diethylamino)propyljoxy}-6 389 (mtyoyq~aO--'ox)3fur~ey)'r A A B (4-fluoropheuy)-2,3-dmethylcyclopropane-1, 1 dimaboxamide (JR,2R)-N-[3-fluoro-4-(f 6-Qnethyloxy)-7-[(3 390 piperazin-1-ylpropyl)oxylquinezolin-4- A A A yI }oxy)phenyl]-N-(4-fluorophenyl)-2 rnethylcyclopropane-1, 1-dicarbcvanaide (2R,3R)-N-(4-f [7-4 [2-(diethyla inoathyl~oxy)-6 391 (me-tbyloxy)quinollnA-yfloxy}-3-fluorophenyl)-N'-(4- A AB fluoropheuyl)-2,3-dmthylcyclopropane-1, 1 dicarboxamaide N-(4-{ [6,7-bis(methyloxy)qulnolin-4-yljoxy}phe~nyl)-' 392 N-[(4-fluorophenyl)xnethyljcyclopropane-1,1- B B A dicarboxamide N-Q1-f [6,7-bis(niethyloxy)quinoin-4-yl]oxy}phe-nyl) 393 N'-(2-morpholin-4-ylethiyl)cyclopropane-,l- C D B divarboxamide N-(4-f [6,7-bis(methyloxy)quinolin-4-yl]dxKylphenyD) 394 N'-[2-(pipelin-1-ylmethyl)phenyl~cycloplmpane -tl- B D B dicorboxamide N-(4-{ [6,7-bis(methyloxy)quinolin-4-ylloxylphenyl) 395 N-[2-(pyrrolidln-ylmethyI)pheay1]cycoropane-1,1- B C B dicatboxamide N-(4-{ [6,7-bis(methyloxy)quinolin-4-yl]oxylphenyl) 396 N'43-(morpboli-n-4-ylmethyl)phenyllcyclopropane- B3 A A 1,1-clicarboxanaide N-(4-f f6,7-bis(methyloxy)qulnolinA-ylloxylphenyl) 397 N'-(2-Qnorpholin-4-ybnethyl)phenyllcyclopropane- B C B 1, 1-dicarboxanade 38N-(4-{t16,7-bis(methyloxy)quinoin-4yljoxy~pey) N'-phenylcyclopropane- 1, 1-diarboxmnidde N-[3-(amiunome-thyl)phenylJ-N-(4-( [6,7 399 bia(methyloxy)quinolin-4- B A B yljoxylphenyl)cyclopropane-1, 1-dicarboxamide N-(4-{ [6,7-big~methyloxy)quinolin-4-yuoxylphenyl) 400 N'- [3-(piperldin- 1-ylmethyl)phenyllcyckopropane-1, 1- B A diarboxaide N-(4-( [6,7-bie~nethyloxy)quinolin-4-yl~oxylphenyl) 401 N'-[3-(pynnlidin-1-ylmetbyl)phenyl]cyclopropane-1, 1- A A dicarboxainide 293 C:INRr.rbhmCC1WAMUDn31 69_ I.DCC-2IU)7flh ) -293A [0455] The reference in this specification to any prior publication (or information derived from it), or to any matter which is known, is not, and should not be taken as an acknowledgment or admission or any form of suggestion that that prior publication (or information derived from it) or known matter forms part of the common general 5 knowledge in the field of endeavour to which this specification relates. [04561 Throughout this specification and the claims which follow, unless the context requires otherwise, the word "comprise", and variations such as "comprises" and "comprising", will be understood to imply the inclusion of a stated integer or step or group of integers or steps but not the exclusion of any other integer or step or group of integers or 10 steps.

Claims (17)

1. A compound which is represented by the following structure: H H N Na 0 F 5 0 N or a pharmaceutically acceptable salt thereof.

2. A pharmaceutical composition comprising a compound according to claim 1, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. 10

3. A compound according to claim 1, or a pharmaceutical composition according to claim 2, for use in the treatment of diseases or disorders associated with uncontrolled, abnormal, and/or unwanted cellular activities. 15

4. A method of treating diseases or disorders associated with uncontrolled, abnormal and/or unwanted cellular activities comprising administering to a mammal in need thereof a compound according to claim 1, or a pharmaceutical composition according to claim 2.

5. The method according to claim 4, wherein the disease or disorder is stomach 20 cancer.

6. The method according to claim 4, wherein the disease or disorder is esophagus cancer. 25

7. The method according to claim 4, wherein the disease or disorder is kidney cancer. CNRPonb\DCCUAMIQR7337_I.DOC-2"72I1G - 295

8. The method according to claim 4, wherein the disease or disorder is liver cancer.

9. The method according to claim 4, wherein the disease or disorder is ovarian carcinoma. 5

10. The method according to claim 4, wherein the disease or disorder is large bowel cancer.

11. The method according to claim 4, wherein the disease or disorder is brain cancer. 10

12. The method according to claim 4, wherein the disease or disorder is lung cancer.

13. The method according to claim 4, wherein the disease or disorder is prostate cancer. 15

14. The method according to claim 4, wherein the disease or disorder is pancreas cancer.

15. The method according to claim 4, wherein the disease or disorder is skin cancer. 20

16. Use of a compound according to claim 1, or a pharmaceutically acceptable salt thereof, for the manufacture of a medicament for treating diseases or disorders associated with uncontrolled, abnormal, and/or unwanted cellular activities. 25

17. The compound according to claims 1 or 3, or a pharmaceutical composition according to claims 2 or 3, or a method according to any one of claims 4 to 15, or use according to claim 16 substantially as hereinbefore described with reference to the Figures and/or Examples.