AU2007201497B2 - Visual prosthesis including enhanced receiving and stimulating portion - Google Patents

Description

S&F Ref: 693040D1

AUSTRALIA

PATENTS ACT 1990 COMPLETE SPECIFICATION FOR A STANDARD PATENT Name and Address of Applicant Actual Inventor(s): Address for Service: Invention Title: Second Sight Medical Products, Inc., of 12744 San Fernando Road Building Sylmar, California, 91342, United States of America Robert J Greenberg Mark Humayun Jerry Ok Spruson Ferguson St Martins Tower Level 31 Market Street Sydney NSW 2000 (CCN 3710000177) Visual prosthesis including enhanced receiving and stimulating portion The following statement is a full description of this invention, including the best method of performing it known to me/us:- 5845c(742508_1) -1- VISUAL PROSTHESIS INCLUDING ENHANCED RECEIVING AND STIMULATING PORTION FIELD OF THE INVENTION The present invention relates generally to a visual prosthesis for restoring at least partial vision to a user afflicted with photoceptor degeneration.

BACKGROUND

U.S. Patent No. 5,935, 155 describes a visual prosthesis generally comprised of (1) an image acquiring and transmitting portion and a receiving and retina stimulating portion. The acquiring portion includes a camera for generating a visual signal output representative of an acquired image. The stimulating portion includes an electrode array adapted to be operatively attached to the user's retina. The visual signal output is used to modulate a radio frequency (RF) carrier signal which is applied to a primary coil. A secondary coil receives the RF signal which is then demodulated to recover the visual signal output for driving the electrode array to electrically stimulate retinal tissue. In use, the acquiring and transmitting portion is mounted outside of the eye (extraocular) and the receiving and stimulating portion is primarily mounted in the eye (intraocular). The components of the intraocular portion are powered from energy extracted from the transmitted visual signal.

Figure 1 of US Patent No. 5,935, 155 comprises a functional block diagram of the visual prosthesis showing its image acquiring and transmitting portion and its receiving and retina stimulating portion. Figures 2 and 3 respectively show the organization of functional components of the respective portions of Figure 1. Figures 4, 5, and 6 depict alternative arrangements for deploying the prosthesis physical components. In all of the figures, the primary coil is mounted in alignment with the optic axis in front of the eye, e.g.

in an eyeglass lens, frame, or in a soft contact lens. In Figure 4, the secondary coil is implanted behind the iris and a circuit housing is collocated therewith. In Figure 5, the secondary coil is implanted behind the iris but the circuit housing is located outside of the sclera wall. In Figure 6, the secondary coil is placed adjacent the outer sclera surface.

U.S. Patent Nos. 5,800, 530 and 6,120, 538 describe alternative visual prostheses.

SUMMARY

The present disclosure is directed to a visual prosthesis and more particularly to an enhanced receiving and stimulating portion for electrically stimulating retinal tissue to 741946_1.DOC 693040D1 specification -2present an apparent image to a user. The presently disclosed visual prostheses utilize an image acquiring and transmitting portion having an extraocular camera and primary coil.

The camera responds to a real image to generate a real image signal which is coupled, e.g. RF coupling, from the primary coil to the secondary coil of the receiving and stimulating portion.

In accordance with a first aspect of the present disclosure there is provided a prosthesis for at least partially restoring vision to a user suffering from a photoreceptor degenerative condition, said prosthesis including: a real image signal representative of a real image generator; a protective housing containing signal processing circuitry in the vitreous body of a user's eye in good thermal contact therewith; said real image signal coupled to said signal processing circuitry to produce an apparent image signal; an electrode array connected to the user's retina; and said apparent image signal applied to said electrode array.

The prosthesis may include a secondary coil configured for mounting in the vitreous body of a user's eye for responding to a coupled input signal to produce an output signal; an electrode array separate from said secondary coil, but electrically coupled to said secondary coil, and configured for implantation in said user's eye; and signal processing circuitry responsive to said output signal for applying an image signal to said electrode array for stimulating retinal cells in said user's eye. The signal processing circuitry is desirably contained in a hermetically sealed housing configured for mounting in said vitreous body. The housing may be oriented relative to said secondary coil to minimize the generation of eddy currents in said housing. Alternately the signal processing circuitry may be contained in a protective housing configured for extraocular mounting; and further including conductive wires for electrically connecting said signal processing circuitry through the user's scleral wall to said secondary coil and said electrode array. Further, the secondary coil may be configured for mounting in said vitreous body with the axis of said secondary coil extending substantially coincident with the optic axis of the user's eye.

Also the secondary coil may be configured for mounting in said vitreous body with the axis of said secondary coil extending substantially perpendicular with the optic axis of the user's eye and proximate to temporal side of the sclera.

741946_1.DOC 693040D1 specification -3- The prosthesis may further comprise an image acquiring portion for producing a real image signal representative of a real image; and a stimulating portion for electrically stimulating the user's retina to present an apparent image to the user; said stimulating portion including: an array of electrodes mounted in the user's eye proximate to said retina and electrically connected thereto; and a protective housing containing signal processing circuitry responsive to said real image signal for applying an apparent image signal to said electrode array for stimulating said retina to present said apparent image; and wherein said housing is mounted in the vitreous body of the user's eye in good thermal contact therewith. Desirably the image acquiring portion includes a primary coil; and said stimulating portion includes a secondary coil; and wherein said primary and secondary coils are mounted in close proximity for coupling said real image signal from said image acquiring portion to said stimulating portion. The secondary coil may be mounted in the vitreous body of the user's eye in good thermal contact therewith. The housing may be oriented relative to said secondary coil to minimize the generation of eddy currents therein.

The primary and secondary coils are desirably supported substantially coincident with the optic axis of the user's eye.

Also disclosed is a method of deploying a visual prosthesis for a user to at least partially restore vision comprising the steps of: generating a real image signal representative of a real image; mounting a protective housing containing signal processing circuitry in the vitreous body of a user's eye in good thermal contact therewith; coupling said real image signal to said signal processing circuitry to produce an apparent image signal; connecting an electrode array to the user's retina; and applying said apparent image signal to said electrode array.

In accordance with another implementation, the secondary coil is placed within the vitreous body of the user's eye positioned and oriented for good signal coupling to the extraocular primary coil. For example, both coils are located in close proximity substantially coincident with the optic axis of the user's eye. Moreover, the secondary coil is arranged to be in good thermal contact with the vitreous body which acts as a heat sink.

In a significant implementation, a signal processing circuitry electrically connected to the secondary coil is also placed in the vitreous body to assure efficient heat transfer therefrom. The circuitry is preferably contained in a protective hermetically sealed 741946_1.DOC 693040D1 specification housing which preferably comprises a metal can but which also can constitute any coating or envelope for protecting the circuitry from adverse effects of salt water. The circuitry responds to an output signal from the secondary coil to produce an apparent image signal for driving an electrode array. The electrode array is configured to electrically stimulate the eye's retinal tissue to enable a user to perceive an apparent image.

Preferably, the housing, which is preferably metal, is placed and/or oriented in a manner to minimize the generation of eddy currents in the housing wall which would diminish energy transmission efficiency. In one arrangement, the housing is located posteriorly of the secondary coil but oriented with its shortest dimensions perpendicular to the secondary coil axis. In an alternative arrangement, the housing is displaced from the secondary coil axis but in substantially the same plane as the secondary coil.

Desirably, the housing is placed outside the sclera wall and electrically connected through the sclera to the secondary coil and retina electrode array.

In a further implementation, the primary coil and secondary coil are both located to the side of the optic axis outside of the sclera wall enabling them to be closely coupled.

The circuit housing is preferably located very close to the secondary coil and is electrically connected through the sclera to the retina electrode array.

BRIEF DESCRIPTION OF THE FIGURES At least one embodiment of the present invention will now be described with reference to the figures, in which: Figure 1 is a functional block diagram of the visual prosthesis described in U.S.

Patent No. 5935155 showing its image acquiring and transmitting portion and its (2) receiving and retina stimulating portion; Figures 2 and 3 are functional block diagrams respectively showing the organization of the image acquiring and transmitting portion and the receiving and retina stimulating portion.

Figure 4 depicts a simplified cross-section of an eye showing the placement of receiving and stimulating components in accordance with a first implementation; Figure 5 depicts a simplified cross-section of an eye showing the placement of receiving and stimulating components in accordance with a second implementation; Figure 6 depicts a simplified cross-section of an eye showing the placement of receiving and stimulating components in accordance with a third implementation; and 741946_1.DOC 693040D1 specification Figure 7 depicts a simplified cross-section of an eye showing the placement of receiving and stimulating components in accordance with a fourth implementation.

DETAILED DESCRIPTION Figure 1 depicts the visual prosthesis 10 of U.S. Patent No. 5935155 which includes an image capturing element, such as a standard charge coupled device (CCD) camera 12, whose output is processed and encoded in circuit block 14.

This processed and encoded captured real image signal is then coupled via primary coil 16 to a secondary coil 18. For example, the real image signal can be transmitted as a modulated radio frequency (RF) carrier signal. The secondary coil 18 receives the real image signal and applies an output signal to the signal processing circuit block 20. This circuit block 20 decodes and demultiplexes the applied signal and then communicates an apparent image signal to an electrode array 22 which stimulates the retinal cells to produce phosgenes in a pattern to simulate vision.

It should be noted that the dashed line 24 in FIG. 1 is included to functionally separate the image acquiring and transmitting portion 26 from the image receiving and stimulating portion28 of the visual prosthesis 10. The dashed line 24 may or may not indicate the physical separation of extraocular and intraocular components as will be described more fully hereinafter with reference to FIGS. 4-7.

The image acquiring and transmitting portion 26 of the visual prosthesis 10 is illustrated in greater detail in FIG. 2 which shows the output of camera 12 coupled to an image sampler circuit 30 whose output is passed to a pixel encoder 32. The output of encoder 32 is passed to a signal modulator 34 which modulates a radio frequency carrier signal generated by the carrier generator 36.

This RF signal is then applied to the primary coil 16.

The encoding scheme is preferably optimized for the target image resolution which is primarily determined by the size of the implanted electrode array.

The encoded information typically includes such parameters as the magnitude, timing, and sequence of the stimulation pulses which will be generated by the electrode array to simulate the image through retinal stimulation.

The RF signal applied to primary coil 16 is received by the secondary coil 18 of the stimulating portion 28 as illustrated in greater detail in FIG. 3. The secondary coil 18 output is passed to the demodulator 38 where the RF carrier signal is removed and the encoded image signal recovered. The encoded image signal is then passed to a 741946_1.DOC 69304001 specification decoder/demultiplexer 40 which in turn outputs the image information to a current generator 42 which drives the individual electrodes of the electrode array 22. The electric power for components of the image receiving and stimulating portion 28 is derived from the energy contained in the coupled RF signal through rectifier 44.

Attention is now directed to Figure 4 which depicts a first implementation in which all of the components of the receiving and retina stimulating portion 28 are implanted in the vitreous chamber 50 of a user's eye 51. The chamber 50 is filled with the vitreous body 52 which comprises a clear color-less transparent jelly. As depicted in Figure 4, the secondary coil 18 is fixed, e.g. by suture 53 to the adjacent sclera wall 54, just behind the lens 56.

The secondary coil 18 is preferably axially aligned with the extraocular primary coil 16 and the optic axis of the eye. The respective coils are preferably mounted so that their planes are oriented substantially parallel to one another to achieve good signal coupling. The secondary coil 18 is physically and electrically connected58 to signal processing circuitry 20 mounted in housing 60 which preferably comprises a metal can but which can constitute any coating or envelope capable of providing protection from the deleterious effects of salt water. The circuitry 20 in housing 60 is connected via conductor 62 to a flexible electrode array 22 physically and electrically contacting the user's retina 64.

It is significant to note that the secondary coil 18, housing 60 and electrode array 22 are all mounted in the vitreous body 52 in good thermal contact therewith. Thus, the vitreous body acts as a heat sink to cool the coil and-electronic circuitry enabling the system to more efficiently utilize the signal energy derived from primary coil 16.

The housing 60 preferably comprises a hermetically sealed metal container having perpendicular width, depth, and length dimensions. In order to minimize eddy current induction into the housing wall, it is preferable to orient the housing with its smallest dimensions oriented parallel to the plane of coil 18 and preferably displaced from the coil axis.

Attention is now directed to Figure 5 which differs from Figure 4 in that housing is placed to the side of coil 18 where it is fixed to the adjacent sclera wall, rather than hanging in the vitreous body as shown in Figure 4. The arrangement of Figure 5 offers greater mechanical stability and robustness than is available in Figure 4.

741946_1.DOC 693040D1 specification -7- ,I Figure 6 depicts a further implementation in which the housing 60 is affixed to the extraocular side of the adjacent sclera wall. This housing placement has the advantage that essentially no eddy currents will be induced in the housing wall. Although housing O placement is somewhat simplified relative to Figures 4 and 5, it nevertheless requires that conductive leads from the secondary coil and to the electrode array be passed through the sclera wall.

Figure 7 depicts a further alternative implementation in which the housing 60 is N mounted off-axis adjacent to the extraocular side of the adjacent sclera wall with the Ssecondary coil 18 being wound around the housing. This collocation of housing and secondary coil offers the potential for miniaturization. Moreover, the off-axis placement of the secondary coil 18 enables the primary coil 16 to be mounted off-axis and in alignment as shown in Figure 7. This off-axis placement may permit the coils 16, 18 to be placed closer together to increase signal coupling therebetween and the efficiency of the wireless transmission. As in Figure 6, the arrangement of Figure 7 requires that conductive leads pass through the sclera wall for connection to the electrode array 22.

From the foregoing, it should now be appreciated that several enhanced prostheses have been described characterized by one or more of the following features: 1. a secondary coil mounted within the vitreous body 2. a circuitry housing mounted within the vitreous body; 3. a secondary coil and circuitry housing collocated outside of the sclera wall displaced from the optic axis.

Some specific aspects of the present disclosure may now be summarised by the following numbered paragraphs: A prosthesis for at least partially restoring vision to a user suffering from a photoreceptor degenerative condition, said prosthesis including: a secondary coil configured for mounting in the vitreous body of a user's eye for responding to a coupled input signal to produce an output signal an electrode array configured for implantation in said user's eye; and signal processing circuitry responsive to said output signal for applying an image signal to said electrode array for stimulating retinal cells in said user's eye.

The prosthesis of paragraph wherein said signal processing circuitry is contained in a hermetically sealed housing configured for mounting in said vitreous body.

(iii). The prosthesis of paragraph (ii) wherein said housing is oriented relative to said secondary coil to minimize the generation of eddy currents in said housing.

741946_1.DOC 693040D1 specification The prosthesis of paragraph wherein said signal processing circuitry is contained in a protective housing configured for extraocular mounting; and further including conductive wires for electrically connecting said signal processing circuitry through the user's scleral wall to said secondary coil and said electrode array.

The prosthesis of paragraph wherein said secondary coil is configured for mounting in said vitreous body with the axis of said secondary coil extending substantially coincident with the optic axis of the user's eye.

In combination with a user's eye characterized by a lens and a sclera wall enclosing a vitreous chamber containing a vitreous body, and including a retina supported adjacent to said vitreous body proximate to the intraocular side of said sclera wall, a visual prosthesis comprising: a secondary coil for responding to input signal energy to produce an output signal, said coil being mounted in said vitreous chamber in thermal contact with said vitreous body; an array of electrodes implanted proximate to said retina; and signal processing circuitry coupled to said secondary coil and responsive to said output signal for applying an image signal to said array of electrodes for electrically stimulating said retina to present an apparent image to said user.

(vii). The combination of paragraph (vi) further including a hermetically sealed housing containing said signal processing circuitry; and wherein said housing is supported in said vitreous chamber in thermal contact with said vitreous body.

(viii). The combination of paragraph (vii) wherein said housing defines first and second perpendicularly oriented dimensions and wherein the housing is oriented in said vitreous chamber with the lesser of said dimensions extending substantially perpendicular to the axis of said secondary coil.

The combination of paragraph (vi) further including a housing containing said signal processing circuitry; said housing being mounted proximate to the extraocular side of said sclera wall; and conductive wires electrically connecting said signal processing circuitry through said sclera wall to said secondary coil and said array of electrodes.

The combination of paragraph (vi) wherein said secondary coil is mounted with its axis substantially coincident with the optic axis of said user's eye.

A visual prosthesis for at least partially restoring vision to a user suffering from a photoceptor degenerative condition, said prosthesis comprising an image acquiring portion for producing a real image signal representative of a real image; and a stimulating portion for electrically stimulating the user's retina to present an apparent image to the 741946_1.DOC 693040D1 specification -9user; said stimulating portion including an array of electrodes mounted in the user's eye proximate to said retina and electrically connected thereto; and a protective housing containing signal processing circuitry responsive to said real image signal for applying an apparent image signal to said electrode array for stimulating said retina to present said apparent image; and wherein said housing is mounted in the vitreous body of the user's eye in good thermal contact therewith.

(xii). The prosthesis of paragraph (xi) wherein said image acquiring portion includes a primary coil; and said stimulating portion includes a secondary coil; and wherein said primary and secondary coils are mounted in close proximity for coupling said real image signal from said image acquiring portion to said stimulating portion.

(xiii). The prosthesis of paragraph (xii) wherein said secondary coil is mounted in the vitreous body of the user's eye in good thermal contact therewith.

(xiv). The prosthesis of paragraph (xii) wherein said primary and secondary coils are supported substantially coincident with the optic axis of the user's eye.

The prosthesis of paragraph (xiii) wherein said housing is oriented relative to said secondary coil to minimize the generation of eddy currents therein.

(xvi). A visual prosthesis for at least partially restoring vision to a user suffering from a photoceptor degenerative condition, said prosthesis comprising: an image acquiring portion including an extraocular primary coil for producing a real image signal representative of a real image; and a stimulating portion. for electrically stimulating the user's-retina to present an apparent image to the user; said stimulating portion including a secondary coil coupled to said primary coil for producing an output signal in response to said real image signal an array of electrodes mounted in the user's eye proximate to said retina and electrically connected thereto; and a protective housing containing signal processing circuitry responsive to said output signal for applying an apparent image signal to said electrode array for stimulating said retina to present said apparent image; and wherein said housing is mounted adjacent to the extraocular side of the user's sclera wall.

(xvii). The prosthesis of paragraph (xvi) wherein said secondary coil is mounted in the vitreous body of the user's eye.

(xviii). The prosthesis of paragraph (xvi) wherein said primary coil and said secondary coil are mounted substantially in alignment with the optic axis of the user's eye.

741946 1.DOC 693040D1 specification (xix). The prosthesis of paragraph (xvi) wherein said primary coil and said secondary coil are substantially aligned with one another along an axis displaced from the optic axis of the user's eye.

A method for implanting a visual prosthesis in the eye of a user including: fixing a secondary coil in the vitreous chamber of the user's eye in thermal contact with the vitreous body in the chamber; mounting a protective housing containing signal processing circuitry in close proximity to said secondary coil connecting an electrode array to the user's retina; and electrically connecting said signal processing circuitry to said secondary coil and said electrode array.

(xxi). A method of deploying a visual prosthesis for a user to at least partially restore vision comprising the steps of: generating a real image signal representative of a real image; mounting a protective housing containing signal processing circuitry in the vitreous body of a user's eye in good thermal contact therewith; coupling said real image signal to said signal processing circuitry to produce an apparent image signal connecting an electrode array to the user's retina; and applying said apparent image signal to said electrode array.

Although only a limited number of embodiments of the invention have been specifically described, it is recognized that various modifications and alternatives will occur to those skilled in the art which fall within the spirit and scope of the invention as defined by the appended claims.

741946_1.DOC 69304001 specification

Claims (13)

1. A prosthesis for at least partially restoring vision to a user suffering from a photoreceptor degenerative condition, said prosthesis including: a real image signal representative of a real image generator; a protective housing containing signal processing circuitry in the vitreous body of a user's eye in good thermal contact therewith; said real image signal coupled to said signal processing circuitry to produce an apparent image signal; an electrode array connected to the user's retina; and said apparent image signal applied to said electrode array.

2. The prosthesis of claim 1 including: a secondary coil configured for mounting in the vitreous body of a user's eye for responding to a coupled input signal to produce an output signal; an electrode array separate from said secondary coil, but electrically coupled to said secondary coil, and configured for implantation in said user's eye; and signal processing circuitry responsive to said output signal for applying an image signal to said electrode array for stimulating retinal cells in said user's eye.

3. The prosthesis of claim 1 wherein said signal processing circuitry is contained in a hermetically sealed housing configured for mounting in said vitreous body.

4. The prosthesis of claim 3 wherein said housing is oriented relative to said secondary coil to minimize the generation of eddy currents in said housing.

The prosthesis of claim 1 wherein said signal processing circuitry is contained in a protective housing configured for extraocular mounting; and further including conductive wires for electrically connecting said signal processing circuitry through the user's scleral wall to said secondary coil and said electrode array. 741946_1.D0C 693040D1 specification -12-

6. The prosthesis of claim 1 wherein said secondary coil is configured for mounting in said vitreous body with the axis of said secondary coil extending substantially coincident with the optic axis of the user's eye.

7. The prosthesis of claim 1 wherein said secondary coil is configured for mounting in said vitreous body with the axis of said secondary coil extending substantially perpendicular with the optic axis of the user's eye and proximate to temporal side of the sclera.

8. The prosthesis of claim 1 comprising: an image acquiring portion for producing a real image signal representative of a real image; and a stimulating portion for electrically stimulating the user's retina to present an apparent image to the user; said stimulating portion including: an array of electrodes mounted in the user's eye proximate to said retina and electrically connected thereto; and a protective housing containing signal processing circuitry responsive to said real image signal for applying an apparent image signal to said electrode array for stimulating said retina to present said apparent image; and wherein said housing is mounted in the vitreous body of the user's eye in good thermal contact therewith.

9. The prosthesis of claim 8 wherein said image acquiring portion includes a primary coil; and said stimulating portion includes a secondary coil; and wherein said primary and secondary coils are mounted in close proximity for coupling said real image signal from said image acquiring portion to said stimulating portion.

10. The prosthesis of claim 9 wherein said secondary coil is mounted in the vitreous body of the user's eye in good thermal contact therewith.

11. The prosthesis of claim 10 wherein said housing is oriented relative to said secondary coil to minimize the generation of eddy currents therein.

12. The prosthesis of claim 9 wherein said primary and secondary coils are supported substantially coincident with the optic axis of the user's eye. 741946_1.DOC 693040D1 specification

-13- O CN 13. A method of deploying a visual prosthesis for a user to at least partially restore vision comprising the steps of: generating a real image signal representative of a real image; Smounting a protective housing containing signal processing circuitry in the vitreous body of a user's eye in good thermal contact therewith; C coupling said real image signal to said signal processing circuitry to produce an Sapparent image signal; CN connecting an electrode array to the user's retina; and 0 applying said apparent image signal to said electrode array. N, Dated this 4 th Day of April, 2007 Second Sight Medical Products, Inc. Patent Attorneys for the Applicant Spruson&Ferguson 741946_1.DOC 693040D1 specification