AU2003286741A8 - Methods and compositions for diagnosis and therapy of parkin-associated disorders - Google Patents

Methods and compositions for diagnosis and therapy of parkin-associated disorders

Info

Publication number
AU2003286741A8
AU2003286741A8 AU2003286741A AU2003286741A AU2003286741A8 AU 2003286741 A8 AU2003286741 A8 AU 2003286741A8 AU 2003286741 A AU2003286741 A AU 2003286741A AU 2003286741 A AU2003286741 A AU 2003286741A AU 2003286741 A8 AU2003286741 A8 AU 2003286741A8
Authority
AU
Australia
Prior art keywords
parkin
diagnosis
therapy
compositions
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003286741A
Other versions
AU2003286741A1 (en
Inventor
Carlo M Croce
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Thomas Jefferson University
Original Assignee
Thomas Jefferson University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomas Jefferson University filed Critical Thomas Jefferson University
Publication of AU2003286741A8 publication Critical patent/AU2003286741A8/en
Publication of AU2003286741A1 publication Critical patent/AU2003286741A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/53Ligases (6)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93Ligases (6)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00Reverse transcribing RNA viruses
    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/16011Human Immunodeficiency Virus, HIV
    • C12N2740/16041Use of virus, viral particle or viral elements as a vector
    • C12N2740/16043Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/9015Ligases (6)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2003286741A 2003-05-02 2003-10-28 Methods and compositions for diagnosis and therapy of parkin-associated disorders Abandoned AU2003286741A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US46736003P 2003-05-02 2003-05-02
US60/467,360 2003-05-02
PCT/US2003/034268 WO2004098377A2 (en) 2003-05-02 2003-10-28 Methods and compositions for diagnosis and therapy of parkin-associated disorders

Publications (2)

Publication Number Publication Date
AU2003286741A8 true AU2003286741A8 (en) 2004-11-26
AU2003286741A1 AU2003286741A1 (en) 2004-11-26

Family

ID=33435063

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003286741A Abandoned AU2003286741A1 (en) 2003-05-02 2003-10-28 Methods and compositions for diagnosis and therapy of parkin-associated disorders

Country Status (2)

Country Link
AU (1) AU2003286741A1 (en)
WO (1) WO2004098377A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112029738A (en) * 2020-08-18 2020-12-04 浙江省人民医院 Human parkin protein acetylation and application thereof in medicine preparation

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2545383T3 (en) 2005-08-01 2015-09-10 The Ohio State University Research Foundation Methods and compositions based on microRNA for the diagnosis, prognosis and treatment of breast cancer
CN101400361B (en) 2006-01-05 2012-10-17 俄亥俄州立大学研究基金会 Microrna-based methods and compositions for the diagnosis, prognosis and treatment of lung cancer
AU2007205257B2 (en) 2006-01-05 2013-07-25 The Ohio State University Research Foundation MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors
US7985584B2 (en) 2006-03-20 2011-07-26 The Ohio State University Research Foundation MicroRNA fingerprints during human megakaryocytopoiesis
EP2041317A4 (en) 2006-07-13 2009-10-14 Univ Ohio State Res Found Micro-rna-based methods and compositions for the diagnosis and treatment of colon cancer-related diseases
US8071292B2 (en) 2006-09-19 2011-12-06 The Ohio State University Research Foundation Leukemia diagnostic methods
JP5501766B2 (en) 2006-11-01 2014-05-28 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション MicroRNA expression signature to predict survival and metastasis in hepatocellular carcinoma
CN101627134B (en) 2007-01-31 2013-11-06 俄亥俄州立大学研究基金会 Microrna-based methods and compositions for the diagnosis, prognosis and treatment of acute myeloid leukemia (aml)
ES2536907T3 (en) 2007-06-08 2015-05-29 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Methods to determine the subtype of a hepatocellular carcinoma
EP2167521A4 (en) 2007-06-15 2011-11-23 Univ Ohio State Res Found ONCOGENIC ALL-1 FUSION PROTEINS FOR TARGETING DROSHA-MEDIATED microRNA PROCESSING
CN101809169B (en) 2007-07-31 2013-07-17 俄亥俄州立大学研究基金会 Methods for reverting methylation by targeting DNMT3A and DNMT3B
ES2562077T3 (en) 2007-08-03 2016-03-02 The Ohio State University Research Foundation Ultraconserved regions encoding RNAnc
CN101836112A (en) 2007-08-22 2010-09-15 俄亥俄州立大学研究基金会 Methods and compositions for inducing deregulation of EPHA7 and ERK phosphorylation in human acute leukemias
WO2009055773A2 (en) 2007-10-26 2009-04-30 The Ohio State University Research Foundation Methods for identifying fragile histidine triad (fhit) interaction and uses thereof
ES2433940T3 (en) 2008-06-11 2013-12-13 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Use of the miR-26 family as a predictive marker of hepatocellular carcinoma and sensitivity to therapy
EP2504452A4 (en) 2009-11-23 2014-06-11 Univ Ohio State Res Found Materials and methods useful for affecting tumor cell growth, migration and invasion
US8946187B2 (en) 2010-11-12 2015-02-03 The Ohio State University Materials and methods related to microRNA-21, mismatch repair, and colorectal cancer
JP2014500258A (en) 2010-11-15 2014-01-09 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション Controlled release mucoadhesion system
JP2014509852A (en) 2011-03-07 2014-04-24 ジ・オハイオ・ステート・ユニバーシティ Mutagenic activity induced by microRNA-155 (miR-155) links inflammation and cancer
US9249468B2 (en) 2011-10-14 2016-02-02 The Ohio State University Methods and materials related to ovarian cancer
JP2015501843A (en) 2011-12-13 2015-01-19 オハイオ・ステイト・イノベーション・ファウンデーション Methods and compositions relating to miR-21 and miR-29a, exosome inhibition, and cancer metastasis
AU2013209477B2 (en) 2012-01-20 2016-12-08 The Ohio State University Breast cancer biomarker signatures for invasiveness and prognosis
WO2013113762A1 (en) * 2012-01-31 2013-08-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and kits for predicting the risk of having a cutaneous melanoma in a subject
CN107412727B (en) * 2017-03-16 2021-03-26 北京热休生物技术有限公司 Application of complex formed by polypeptide of protein PACRGL and heat shock protein gp96 in preparation of medicine for treating and preventing cancer

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5952221A (en) * 1996-03-06 1999-09-14 Avigen, Inc. Adeno-associated virus vectors comprising a first and second nucleic acid sequence
US6448041B1 (en) * 2000-12-18 2002-09-10 Incyte Genomics, Inc. Colon cancer marker
US6855554B2 (en) * 2001-09-21 2005-02-15 Board Of Regents, The University Of Texas Systems Methods and compositions for detection of breast cancer

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112029738A (en) * 2020-08-18 2020-12-04 浙江省人民医院 Human parkin protein acetylation and application thereof in medicine preparation

Also Published As

Publication number Publication date
WO2004098377A3 (en) 2005-05-06
WO2004098377A2 (en) 2004-11-18
AU2003286741A1 (en) 2004-11-26

Similar Documents

Publication Publication Date Title
AU2003286741A8 (en) Methods and compositions for diagnosis and therapy of parkin-associated disorders
IL175529A0 (en) Methods and compositions for the treatment of metabolic disorders
ZA200607433B (en) Methods and compositions for the treatment of gastroin-testinal disorders
EP1571968A4 (en) Compositions and methods for the diagnosis and treatment of tumor
EP1589933A4 (en) Compositions and methods for the diagnosis and treatment of tumor
PL1644021T3 (en) Methods and compositions for the treatment of gastrointestinal disorders
EP1737453A4 (en) Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of skin diseases or disorders
EP1572091A4 (en) Compositions and methods for the diagnosis and treatment of tumor
IL172194A0 (en) Methods and compositions for treating amyloid-related diseases
EP1699431A4 (en) Compositions for treatment of ear disorders and methods of use thereof
EP1578996A4 (en) Compositions and methods for the diagnosis and treatment of tumor
EP1553912A4 (en) Compositions and methods for the diagnosis and treatment of tumor
EP1575571A4 (en) Compositions and methods for the diagnosis and treatment of tumor
EP1680145A4 (en) Methods and compositions for the treatment of neurological disease
ZA200510282B (en) Compositions and methods for the diagnosis and treatment of tumor
EP1478438A4 (en) Methods and compositions for the treatment of asthma and related disorders
PL371281A1 (en) Methods and compositions for the treatment of eye diseases
AU2003237792A8 (en) Compositions and methods for the diagnosis and treatment of tumor
AUPS194902A0 (en) Compositions and methods for diagnosis and treatment of cardiovascular disorders
EP1797430A4 (en) Methods and compositions for the diagnosis and treatment of cancer
EP1539100A4 (en) Composition and methods for the treatment of skin disorders
EP1686973A4 (en) Compositions and methods for treatment of cardiovascular disorders and diseases
ZA200604365B (en) Compositions and methods for the diagnosis and treatment of tumor
EP1546189A4 (en) Novel compositions and methods for the treatment of immune-related diseases
EP1646869A4 (en) Compositions and methods for the therapy and diagnosis of lung cancer

Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase