AU2003272175A1 - Reactivation of wild type p53 in human tumour cells by a low molecular weight compound - Google Patents

Reactivation of wild type p53 in human tumour cells by a low molecular weight compound

Info

Publication number
AU2003272175A1
AU2003272175A1 AU2003272175A AU2003272175A AU2003272175A1 AU 2003272175 A1 AU2003272175 A1 AU 2003272175A1 AU 2003272175 A AU2003272175 A AU 2003272175A AU 2003272175 A AU2003272175 A AU 2003272175A AU 2003272175 A1 AU2003272175 A1 AU 2003272175A1
Authority
AU
Australia
Prior art keywords
reactivation
molecular weight
low molecular
wild type
weight compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003272175A
Inventor
Natalia Issaeva
Galina Selivanova
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aprea Therapeutics AB
Original Assignee
Aprea AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE0203105A external-priority patent/SE0203105D0/en
Application filed by Aprea AB filed Critical Aprea AB
Publication of AU2003272175A1 publication Critical patent/AU2003272175A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2003272175A 2002-10-21 2003-10-21 Reactivation of wild type p53 in human tumour cells by a low molecular weight compound Abandoned AU2003272175A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US42004502P 2002-10-21 2002-10-21
US60/420,045 2002-10-21
SE0203105-2 2002-10-21
SE0203105A SE0203105D0 (en) 2002-10-21 2002-10-21 Reactivation of wild type P53 in human tumour cells by a low molecular weight compound
PCT/SE2003/001635 WO2004035580A1 (en) 2002-10-21 2003-10-21 Reactivation of wild type p53 in human tumour cells by a low molecular weight compound

Publications (1)

Publication Number Publication Date
AU2003272175A1 true AU2003272175A1 (en) 2004-05-04

Family

ID=32109589

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003272175A Abandoned AU2003272175A1 (en) 2002-10-21 2003-10-21 Reactivation of wild type p53 in human tumour cells by a low molecular weight compound

Country Status (2)

Country Link
AU (1) AU2003272175A1 (en)
WO (1) WO2004035580A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007139499A1 (en) * 2006-05-31 2007-12-06 Aprea Ab Compounds for use as a medicament
US7732447B2 (en) 2006-06-22 2010-06-08 Cephalon, Inc. Fused [d]pyridazin-7-ones
UA107652C2 (en) 2008-10-06 2015-02-10 Incuron Llc Carbazole compounds and therapeutic uses of the compounds
JP2012512246A (en) 2008-12-17 2012-05-31 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング C-ring modified tricyclic benzonaphthyridinone protein kinase inhibitors and uses thereof
CN104981697B (en) 2013-02-11 2017-08-04 英丘伦有限责任公司 Promote purposes of the chromatin transcription complex (FACT) in cancer
CN104744340B (en) * 2013-12-30 2017-11-03 中国人民大学 Polysubstituted carbazole compound and preparation method and application
CN106572992A (en) 2014-04-06 2017-04-19 英丘伦有限责任公司 Combination therapies with CURAXINS
US9840503B2 (en) 2015-05-11 2017-12-12 Incyte Corporation Heterocyclic compounds and uses thereof
WO2017027717A1 (en) 2015-08-12 2017-02-16 Incyte Corporation Bicyclic fused pyrimidine compounds as tam inhibitors
WO2017035366A1 (en) 2015-08-26 2017-03-02 Incyte Corporation Pyrrolopyrimidine derivatives as tam inhibitors
CA3019145A1 (en) 2016-03-28 2017-10-05 Incyte Corporation Pyrrolotriazine compounds as tam inhibitors
CN106977515A (en) * 2017-04-13 2017-07-25 河北科技大学 β carbolines, γ carboline derivatives, preparation method and the usage
GEP20227429B (en) 2017-09-27 2022-10-25 Incyte Corp Salts of pyrrolotriazine derivatives useful as tam inhibitors
CZ308104B6 (en) * 2018-03-12 2020-01-08 Ústav organické chemie a biochemie AV ČR, v. v. i. Pyridinopyrrolopyrimidine ribonucleosides for therapeutic use
AR117600A1 (en) 2018-06-29 2021-08-18 Incyte Corp FORMULATIONS OF AN AXL / MER INHIBITOR

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2579208B1 (en) * 1985-03-22 1987-05-07 Sanofi Sa NOVEL 5-H PYRIDO (3 ', 4': 4.5) PYRROLO (3,2-C) PYRIDINE DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR ANTI-TUMOR ACTIVITY
FR2595701B1 (en) * 1986-03-17 1988-07-01 Sanofi Sa PYRIDO-INDOLE DERIVATIVES, THEIR APPLICATION AS MEDICAMENTS AND THE COMPOSITIONS CONTAINING THEM
US4754038A (en) * 1987-02-26 1988-06-28 American Home Products Corporation Carboline histamine H1 antagonists
RU2106864C1 (en) * 1995-10-23 1998-03-20 Николай Серафимович Зефиров New approach to treatment of alzheimer's disease
EP1002535A1 (en) * 1998-10-28 2000-05-24 Hrissanthi Ikonomidou New use of glutamate antagonists for the treatment of cancer

Also Published As

Publication number Publication date
WO2004035580A1 (en) 2004-04-29

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase