AU2003255479B2 - Blocking device for a sprung lock with a spring operation - Google Patents

Blocking device for a sprung lock with a spring operation Download PDF

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Publication number
AU2003255479B2
AU2003255479B2 AU2003255479A AU2003255479A AU2003255479B2 AU 2003255479 B2 AU2003255479 B2 AU 2003255479B2 AU 2003255479 A AU2003255479 A AU 2003255479A AU 2003255479 A AU2003255479 A AU 2003255479A AU 2003255479 B2 AU2003255479 B2 AU 2003255479B2
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AU
Australia
Prior art keywords
blocking device
blocking
spindle
housing part
slider
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU2003255479A
Other versions
AU2003255479C1 (en
AU2003255479A1 (en
Inventor
Michael Schyra
Herbert Wachtel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Original Assignee
Boehringer Ingelheim International GmbH
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Filing date
Publication date
Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Publication of AU2003255479A1 publication Critical patent/AU2003255479A1/en
Application granted granted Critical
Publication of AU2003255479B2 publication Critical patent/AU2003255479B2/en
Publication of AU2003255479C1 publication Critical patent/AU2003255479C1/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/50—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/0081—Locking means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
    • B05B11/1042—Components or details
    • B05B11/108—Means for counting the number of dispensing strokes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
    • B05B11/109—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle the dispensing stroke being affected by the stored energy of a spring
    • B05B11/1091—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle the dispensing stroke being affected by the stored energy of a spring being first hold in a loaded state by locking means or the like, then released
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/27—General characteristics of the apparatus preventing use
    • A61M2205/273—General characteristics of the apparatus preventing use preventing reuse, e.g. of disposables
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules

Description

au-fil COMMONWEALTH OF AUSTRALIA PATENTS ACT 1990 IN THE MATTER of a Patent Application by Boehringer Ingelheim International GmbH VERIFICATION OF TRANSLATION Patent Application No.: PCT/EP2003/009364 (WO 2004/024340) I, JANE ROBERTA MANN, of Frank B. Dehn Co., 59 St Aldates, Oxford OX1 1ST, am the translator of the documents attached and I state that the following is a true translation to the best of my knowledge and belief of the specification as published of International Patent Application No. PCT/EP2003/009364 (WO 2004/024340) of Boehringer Ingelheim International GmbH.
Signature of translator Dated: 14th January 2005 1 Blocking device for a locking-stressing-mechanism having a spring-actuated output drive device The invention relates to a blocking device by means of which the proper use of a device equipped with a lockingstressing mechanism and a spring-actuated output drive is prevented after a given number of actuations. The device may be, for example, a high pressure atomiser or a needleless injector.
The aim of the invention is to reliably limit the period of use of such a device and meet safety requirements.
The reasons for the limitation may be based on hygiene, medical or technical considerations.
The locking-stressing-mechanism, which is to be blocked after the permitted period of use, has elapsed preferably comprises a helical thrust gear accommodated in a manually operated device, by means of which a rotary movement is converted into a linear movement and an operating spring is put under tension. The operating spring acts on a spring component of the lockingstressing-mechanism the movement of which is initially blocked as soon as the operating spring has reached the tensioned state. Secured in the spring component there may be a piston movably mounted in a cylinder. Inside the cylinder, in front of the piston, is a liquid which is expelled out through a nozzle as the locking mechanism of the locking-stressing mechanism is actuated by the piston driven by the operating spring. The number of 2 actuations of the locking-stressing-mechanism and hence of the device can be counted by a mechanical counter.
WO-93/21980 describes a metered-dose inhaler. The dose of a substance to be inhaled is introduced, by means of a hand-operated device, from a supply of the substance contained in the inhaler, into a chamber from which the dose is expelled with the current of air which the user sucks in through the inhaler as they breathe in. The metered-dose inhaler is fitted with a counter which comprises a rotatable screw spindle and a rod, one end of which engages in the form of a nose in the thread of the screw spindle. The rod moves parallel to the screw spindle as the rotation of the spindle increases. The counter indicates, by means of the position of the noselike end of the rod, the number of doses which have already been taken out of the supply of substance, or those which can still be taken out. The other end of the rod is movably held in a guide shaft into which the rod extends more deeply as the rotation of the screw spindle increases. As soon as the supply of substance in the inhaler is coming to an end, the nose-like end of the rod engaging in the screw spindle reaches that part of the spindle which has a number of courses of thread having a greater pitch than the rest of the screw spindle. As a result, on each rotation of the screw spindle, the rod moves along faster than before. The other end of the rod meanwhile bears on a flexible lever, and further actuation of the metered-dose inhaler is prevented.
WO-97/20590 describes a locking stressing mechanism for a spring-actuated output drive. WO-97/24586 describes a mechanical counter for a metering device. WO-97/12687 describes a device for generating high pressure in a fluid in a miniature arrangement provided with a locking stressing mechanism and a counter. The apparatus is used 3 to atomise a fluid to produce an inhalable aerosol. WO- 01/64268 describes a needleless injector which contains a locking stressing mechanism.
The pieces of equipment mentioned above by way of example are intended for repeated use, e.g. for repeated atomisation of a given amount of liquid to produce an aerosol for inhalation into the lungs, or for needleless injection of a given quantity of liquid underneath the skin of humans or animals. The quantity of liquid atomised or injected may contain a therapeutically active substance.
The problem of the present invention is to provide a device for an apparatus which will reliably, effectively and finally prevent further use of the apparatus after a given number of actuations if there is a compelling reason for this. The apparatus comprises a lockingstressing-mechanism with an operating spring and a spring transfer member in which is accommodated a piston which is mounted to be movable in a cylinder. The components are housed in a two-part housing which comprises an upper housing part and a lower housing part. The two housing parts are mounted to be rotatable relative to each other.
The operating spring is tensioned by means of a screw thrust gear by manually rotating the two housing parts relative to each other. At the same time as the housing parts are rotated relative to each other, a mechanical counter is actuated which comprises a threaded spindle and a slider. The threaded spindle is mounted in the wall of the lower housing part. The slider is moved up or down the spindle by an amount which depends on the number of rotations of the two housing parts relative to each other.
4 This problem is solved according to the invention by a device having the following characterising features: A recess is provided in the outer wall of the lower housing part and in the inner wall of the upper housing part. The two recesses are opposite each other when the two housing parts are in a given rotary position.
In the recess in the lower housing part there is a movable blocking element which is located only in this recess before the blocking device is activated and allows the two housing parts to rotate relative to each other. After the activation of the blocking device the blocking element is located in both recesses and prevents the two housing parts from rotating relative to each other.
By means of a push-rod which co-operates with the slider on the spindle of the counter, the blocking element is moved out of its resting position into the position which it occupies after activation of the blocking device.
On the one hand, the push-rod may be mounted on the slider to the side of the spindle of the counter. In this embodiment of the blocking device, during normal use of the device, the slider moves towards the upper spindle mounting and towards the upper housing part.
The recess in the wall of the lower housing part is mounted next to the axis of the counter spindle.
Before the slider makes contact with the upper spindle mounting, the push-rod moves the blocking element located in the recess in the wall of the lower housing part out of its resting position and thereby activates the blocking device.
The push-rod can also be constructed as an extension of the blocking element. In this embodiment, the end of the push-rod projects into the path travelled by the slider during normal use of the device before 'the slider comes to abut on the upper mounting of the counter spindle. This embodiment works in exactly the same way as the embodiment described above.
In another embodiment of the blocking device the push rod may be constructed as an extension of the counter spindle and may project beyond the upper spindle mounting. In this case the counter spindle is mounted
I,
to be axially moveable. The recess in the wall of the lower housing part is preferably provided on the axis of the counter spindle. Before the blocking device is activated the counter spindle is pressed against the lower spindle mounting by a spring, e.g. a helical spring. In this embodiment of the blocking device the slider moves towards the lower spindle mounting during normal use of the device. As soon as the slider comes to abut on the lower spindle mounting, the counter spindle moves axially towards the upper housing part as it continues to rotate. The extension of the counter spindle in the form of a push rod moves the blocking element located in the recess in the wall of the lower housing part out of its resting position, thereby activating the blocking device.
In a reversal of the embodiments described, the blocking element may be pulled out of its resting position by the slider.
The blocking element located in the wall of the lower housing part may be axially or radially moveable. The blocking element may be a leaf spring, preferably a pre-stressed leaf spring with two legs preferably made of metal.
6 The blocking device according to the invention has the following advantages: It is suitable for miniaturised equipment.
It is arranged between the housing parts which overlap one another and in its position of use in a device it is inaccessible to the user.
It is easy to assemble.
A blocking element in the form of a pre-stressed leaf spring with two legs is secured against movement in its resting position without any additional effort.
A pre-stressed leaf spring can be pushed into or pulled out of its resting position with relatively little force.
0 A pre-stressed leaf spring with two legs jumps abruptly from its resting position into the position it occupies when the blocking device is activated, as soon as it has been moved a certain distance by means of a push rod. Thus the response point of the blocking device is precisely fixed.
The rotation of the two housing parts relative to one another is blocked directly as soon as the blocking element, which was originally located in the recess in the wall of the lower housing part, is situated in both recesses at the same time.
The activated blocking device which contains a pre-stressed metal leaf spring can only be overcome by a force moment amounting to several Newton metres, which will destroy the blocked device.
The blocking device according to the invention is used for example in a high pressure atomiser or in a needleless injector. A medical liquid administered using such a device may contain a drug dissolved in a 7 solvent. Suitable solvents include, for example, water, ethanol or mixture thereof. The drugs in question may be, for example, Berotec (fenoterol hydrobromide; 1-(3,5-dihydroxy-phenyl)-2-[[1-(4hydroxy-benzyl)-ethyl]-amino]-ethanol-hydrobromide), Atrovent (ipratropium bromide), Berodual (combination of fenoterol hydrobromide and ipratropium bromide), salbutamol (or albuterol), Combivent, Oxivent (oxitropium bromide), Ba 679 (tiotropium bromide), BEA 2108 (tropenol di-(2-thienyl glycolate), flunisolide, budesonide'and others.
A preferred embodiment of the blocking device according to the invention will be explained in more detail with reference to the figures. Figures 1 and 2 show partial longitudinal sections through the wall of the lower and upper housing part as well as a leaf spring as a blocking element and a push rod level with the recesses in the walls. The longitudinal section runs parallel to the axis of the lower and upper housing parts.
Figures 3 and 4 show a longitudinal elevation of a device cut open in the region of the counter and the blocking device.
In Figures 1 and 3 the blocking device is shown in the resting position. The blocking element is in its resting position and is located only in the recess in the wall of the lower housing part. Figures 2 and 4 show the blocking device activated. The blocking element has been moved out of its resting position and is located in both recesses in the walls of the two housing parts.
8 The upper housing part overlaps the lower housing part The gap between the two housing parts, mounted to be rotatable relative to each other, is exaggerated in the drawing. In the upper housing part there is the recess and in the lower housing part the recess The recess contains an undercut projection which is connected to the lower housing part at the side walls of the recess The push rod (8a, 8b) projects into the recess in the wall of the lower housing part. The push rod is mounted on the slider (not shown in Figures 1 and 2) which is located on the spindle (not shown in Figures 1 and 2) of the counter. The blocking element is a leaf spring with two legs. In its resting position the leaf spring (7a) is jammed between the base of the recess and the undercut projection The push rod (8a) is shown in a position which it occupies shortly before making contact with the leaf spring As the device is further actuated the push rod moves towards the leaf spring and pushes it out of its resting position, until the end of the leaf spring jumps forward behind the projection If the two recesses and are not yet located opposite each other at this moment the end of the leaf spring which has jumped forward behind the projection first makes contact with the inner wall of the upper housing part. As soon as the two recesses and are located opposite one another, as the rotation of the two housing parts relative to each other continues, the end of the leaf spring jumps into the recess The leaf spring (7b) is thus located in both recesses and the blocking device is activated.
Figure 3 shows the spindle (10) of the counter on which the slider is located in its (lower) starting position before the device is used for the -9first time. The push rod (8a) is at some distance from the leaf spring (7a) In Figure 4 the slider on the spindle is in its (top) end position in which it has made contact with the end of the leaf spring (8b) and pushed the leaf spring out of its resting position, as a result of which the blocking device has been activated.
The pre-stressed leaf spring (7a; 7b) shown in the figures as a blocking element consists for example of spring steel about 0.2 mm thick and is about 3.5 mm wide. The two recesses in the walls of the two housing parts are about 4 mm wide and about 1 mm deep.
Once the blocking device has been activated the two housing parts can only be rotated relative to one another by the application of considerable force (force moment about 3 Newton metres), but this destroys the device and makes it unusable.

Claims (9)

1. Blocking device for an apparatus which comprises a locking-stressing-mechanism with an operating spring and a spring transfer member in which is accommodated a piston which is mounted to be moveable in a cylinder, and these components are housed in a two part housing which comprises an upper housing part and a lower housing part, and the two parts are mounted to be rotatable relative to each other, and the operating spring is tensioned by means of a screw thrust gear by manually rotating the two housing parts relative to each other, and at the same time as the housing parts are rotated relative to each other a mechanical counter is actuated which comprises a threaded spindle and a slider, and the threaded spindle is mounted in the wall of the lower housing part, and the slider is moved along the spindle by an amount which depends on the number of rotations of the two housing parts relative to each other, wherein a recess is provided in the outer wall of the lower housing part and in the inner wall of the upper housing part, and the two recesses are opposite each other when the two housing parts are in a given rotary position, and a moveable blocking element is provided which is located initially only in the recess in the lower housing part, and a push rod for moving the blocking element is provided which cooperates with the slider on the spindle of the counter.
2. Blocking device according to claim 1, wherein the push rod is mounted on the slider. 11
3. Blocking device according to claim 1, wherein Sthe push rod is mounted on the blocking element.
4. Blocking device according to claim i, wherein Sthe push rod is constructed as an extension of the spindle of the counter and the spindle is mounted to be axially moveable.
5. Blocking device according to claim i, wherein Ii Sthe blocking element is moveable in the axial direction.
6. Blocking device according to claim i, wherein the blocking element is a pre-stressed leaf spring.
7. Blocking device according to claims 1 and 6, wherein the blocking element is a pre-stressed leaf spring with two legs and is preferably made of metal.
8. Use of the blocking device according to claim 1 for blocking a high pressure atomiser of miniaturised construction for atomising a liquid which contains a pharmaceutical active substance to produce an aerosol.
9. Use of the blocking device according to claim 1 for blocking a needleless injector of miniaturised construction for injecting a liquid which contains a pharmaceutical active substance into animal or human tissue.
AU2003255479A 2002-08-28 2003-08-23 Blocking device for a sprung lock with a spring operation Expired AU2003255479C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10239443.1 2002-08-28
DE10239443A DE10239443A1 (en) 2002-08-28 2002-08-28 Mechanism comprising a bent leaf spring, is useful for blocking further operation of a device after a specified number of relative rotations of parts of this device
PCT/EP2003/009364 WO2004024340A1 (en) 2002-08-28 2003-08-23 Blocking device for a sprung lock with a spring operation

Publications (3)

Publication Number Publication Date
AU2003255479A1 AU2003255479A1 (en) 2004-04-30
AU2003255479B2 true AU2003255479B2 (en) 2008-05-01
AU2003255479C1 AU2003255479C1 (en) 2008-12-04

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003255479A Expired AU2003255479C1 (en) 2002-08-28 2003-08-23 Blocking device for a sprung lock with a spring operation

Country Status (26)

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EP (1) EP1539368B1 (en)
JP (1) JP4411209B2 (en)
KR (1) KR20050039869A (en)
CN (1) CN100393425C (en)
AR (1) AR041060A1 (en)
AT (1) ATE490823T1 (en)
AU (1) AU2003255479C1 (en)
BR (1) BR0313816B1 (en)
CA (1) CA2497059C (en)
CO (1) CO5720979A2 (en)
CY (1) CY1111877T1 (en)
DE (2) DE10239443A1 (en)
DK (1) DK1539368T3 (en)
ES (1) ES2357570T3 (en)
HK (1) HK1084909A1 (en)
IL (1) IL167102A (en)
MX (1) MXPA05002162A (en)
PE (1) PE20040387A1 (en)
PL (1) PL373917A1 (en)
PT (1) PT1539368E (en)
RU (1) RU2337765C2 (en)
SI (1) SI1539368T1 (en)
TW (1) TW200418541A (en)
UY (1) UY27951A1 (en)
WO (1) WO2004024340A1 (en)
ZA (1) ZA200500083B (en)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9055995B2 (en) 2002-11-04 2015-06-16 Aspire Bariatrics, Inc. Method for treating obesity by extracting food
US7740624B2 (en) 2002-11-04 2010-06-22 Aspiration Medical Technology, Llc Method for treating obesity by extracting food
US7815629B2 (en) 2002-11-04 2010-10-19 Deka Products Limited Partnership Apparatus for treating obesity by extracting food
KR20080042085A (en) 2005-08-24 2008-05-14 베링거 인겔하임 인터내셔날 게엠베하 Atomiser
US8632513B2 (en) 2006-08-03 2014-01-21 Aspire Bariatrics, Inc. Systems and methods for removing ingested material from a stomach
US7648479B2 (en) 2006-08-03 2010-01-19 Deka Products Limited Partnership Systems and methods for removing ingested material from a stomach
UY30892A1 (en) 2007-02-07 2008-09-02 Smithkline Beckman Corp AKT ACTIVITY INHIBITORS
EP2020249A1 (en) 2007-08-01 2009-02-04 Boehringer Ingelheim Pharma GmbH & Co. KG Inhalator
EP2044967A1 (en) * 2007-10-01 2009-04-08 Boehringer Ingelheim Pharma GmbH & Co. KG Atomiser
EP2077132A1 (en) 2008-01-02 2009-07-08 Boehringer Ingelheim Pharma GmbH & Co. KG Dispensing device, storage device and method for dispensing a formulation
ES2546025T3 (en) 2008-01-24 2015-09-17 Vectura Delivery Devices Limited Inhaler
EP2285440B2 (en) 2008-05-02 2018-10-24 Boehringer Ingelheim International GmbH Inhaler
EP3508239B1 (en) 2009-05-18 2020-12-23 Boehringer Ingelheim International GmbH Adapter, inhalant apparatus and atomizer
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
EP2504051B1 (en) 2009-11-25 2019-09-04 Boehringer Ingelheim International GmbH Nebulizer
DE102010001798B4 (en) * 2010-02-11 2012-10-31 Osram Ag Method for operating a light-emitting diode arrangement and switching arrangement
WO2011154295A2 (en) 2010-06-08 2011-12-15 Boehringer Ingelheim International Gmbh Medical device having a counter having a preset counting range, device having counter variation
EP2585151B1 (en) 2010-06-24 2018-04-04 Boehringer Ingelheim International GmbH Nebulizer
EP2447694B1 (en) 2010-10-28 2014-05-21 Boehringer Ingelheim Pharma GmbH & Co. KG Test leak for inspecting leak measurement systems
EP2701780B1 (en) * 2011-04-28 2016-03-30 Sanofi-Aventis Deutschland GmbH Dispense interface with lockout element
WO2012146677A1 (en) * 2011-04-28 2012-11-01 Sanofi-Aventis Deutschland Gmbh Lockout element for dispense interface
WO2012161685A1 (en) * 2011-05-23 2012-11-29 Boehringer Ingelheim International Gmbh Nebulizer
US9827384B2 (en) * 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
ES2670523T3 (en) 2011-08-23 2018-05-30 Aspire Bariatrics, Inc. Enhanced skin port connector and installation method
CN104203312B (en) * 2012-04-05 2017-09-01 赛诺菲-安万特德国有限公司 Including binding agent to stop driving when finishing device lifetime to prevent the drive mechanism of delivery device reused
WO2013152894A1 (en) 2012-04-13 2013-10-17 Boehringer Ingelheim International Gmbh Atomiser with coding means
DE202012008892U1 (en) * 2012-09-14 2013-12-16 5med GmbH nasal applicator
DK2958608T3 (en) 2013-02-23 2019-06-03 Aspire Bariatrics Inc DEVICE AND PROCEDURE FOR DRAINING MATERIAL FROM A MAVE
EP2835146B1 (en) 2013-08-09 2020-09-30 Boehringer Ingelheim International GmbH Nebulizer
CN103693605B (en) 2013-12-23 2016-04-20 深圳市华星光电技术有限公司 A kind of frame glue filling device
GB201610450D0 (en) * 2016-06-15 2016-07-27 Tech Partnership The Plc Counting mechanism
CA3043144A1 (en) * 2016-11-09 2018-05-17 Arven Ilac Sanayi Ve Ticaret A.S. Inhaler device with improved locking clip
EP3884976A1 (en) 2017-07-21 2021-09-29 Boehringer Ingelheim International GmbH Nebulizer
WO2019016409A2 (en) 2017-07-21 2019-01-24 Boehringer Ingelheim International Gmbh Nebulizer and container
US20200384216A1 (en) 2017-12-18 2020-12-10 Boehringer Lngelheim International Gmbh Device for putting an inhaler into a triggering-ready state
DK3727533T3 (en) 2017-12-22 2023-02-06 Softhale Nv BLOCKING DEVICE
EP3563894B1 (en) 2018-05-04 2021-12-22 Boehringer Ingelheim International GmbH Nebulizer and container
JP7202457B2 (en) 2018-09-27 2023-01-11 エスエイチエル・メディカル・アーゲー Aerosol dispenser locking mechanism
CN111195382B (en) * 2018-11-16 2022-04-19 微邦科技股份有限公司 Locking structure of atomization drug delivery device
CN212491038U (en) * 2020-03-18 2021-02-09 苏州天健云康信息科技有限公司 Liquid drug delivery device
EP4175702A1 (en) 2020-07-03 2023-05-10 Boehringer Ingelheim International GmbH Nebulizer

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993021980A1 (en) * 1992-05-05 1993-11-11 Astra Aktiebolag Dosage inhalator with indicating/interrupting means
WO1997012687A1 (en) * 1995-10-04 1997-04-10 Boehringer Ingelheim International Gmbh Device of miniaturised construction for producing high pressure in a fluid to be atomised

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2721106B1 (en) * 1994-06-10 1996-09-13 Step Dose counter for inhalers.
DE19549033C1 (en) * 1995-12-28 1997-05-28 Boehringer Ingelheim Int Mechanical counter for a dosing device

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993021980A1 (en) * 1992-05-05 1993-11-11 Astra Aktiebolag Dosage inhalator with indicating/interrupting means
WO1997012687A1 (en) * 1995-10-04 1997-04-10 Boehringer Ingelheim International Gmbh Device of miniaturised construction for producing high pressure in a fluid to be atomised

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