AU2003242678A1 - Antisense oligonucleotides against pim1 - Google Patents

Antisense oligonucleotides against pim1

Info

Publication number
AU2003242678A1
AU2003242678A1 AU2003242678A AU2003242678A AU2003242678A1 AU 2003242678 A1 AU2003242678 A1 AU 2003242678A1 AU 2003242678 A AU2003242678 A AU 2003242678A AU 2003242678 A AU2003242678 A AU 2003242678A AU 2003242678 A1 AU2003242678 A1 AU 2003242678A1
Authority
AU
Australia
Prior art keywords
antisense oligonucleotides
oligonucleotides against
pim1
against pim1
antisense
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003242678A
Other versions
AU2003242678A8 (en
Inventor
Ozlem Altan
Volker Erdmann
Arnold Grunweller
Jens Kurreck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruenenthal GmbH
Original Assignee
Gruenenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal GmbH filed Critical Gruenenthal GmbH
Publication of AU2003242678A1 publication Critical patent/AU2003242678A1/en
Publication of AU2003242678A8 publication Critical patent/AU2003242678A8/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
AU2003242678A 2002-06-14 2003-06-12 Antisense oligonucleotides against pim1 Abandoned AU2003242678A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10226702.2 2002-06-14
DE2002126702 DE10226702A1 (en) 2002-06-14 2002-06-14 Antisense oligonucleotides against PIM1
PCT/EP2003/006158 WO2003106681A2 (en) 2002-06-14 2003-06-12 Antisense oligonucleotides against pim1

Publications (2)

Publication Number Publication Date
AU2003242678A1 true AU2003242678A1 (en) 2003-12-31
AU2003242678A8 AU2003242678A8 (en) 2003-12-31

Family

ID=29723183

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003242678A Abandoned AU2003242678A1 (en) 2002-06-14 2003-06-12 Antisense oligonucleotides against pim1

Country Status (3)

Country Link
AU (1) AU2003242678A1 (en)
DE (1) DE10226702A1 (en)
WO (1) WO2003106681A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005033310A1 (en) * 2003-10-01 2005-04-14 Grünenthal GmbH Pim-1 specific dsrna compounds
DE102004004894A1 (en) * 2004-01-30 2005-08-18 Grünenthal GmbH Identifying substances that regulate PIM kinases, useful for treatment and diagnosis of urinary incontinence and the urge to urinate, and similar use of PIM proteins or nucleic acids
US20100048671A1 (en) * 2005-05-14 2010-02-25 Yun Qiu Inhibition of the 44 kilodalton isoform of pim-1 kinase restores apoptosis induced by chemotherapeutic drugs in cancer cells
WO2014110574A1 (en) 2013-01-14 2014-07-17 Incyte Corporation Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors
SG10201705662WA (en) 2013-01-15 2017-08-30 Incyte Corp Thiazolecarboxamides and pyridinecarboxamide compounds useful as pim kinase inhibitors
PE20160532A1 (en) 2013-08-23 2016-05-21 Incyte Corp COMPOUND OF FURO CARBOXAMIDE AND TENOPYRIDINE USEFUL AS INHIBITORS OF PIM KINASES
US9580418B2 (en) 2014-07-14 2017-02-28 Incyte Corporation Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
WO2016010897A1 (en) 2014-07-14 2016-01-21 Incyte Corporation Bicyclic heteroaromatic carboxamide compounds useful as pim kinase inhibitors
WO2016196244A1 (en) 2015-05-29 2016-12-08 Incyte Corporation Pyridineamine compounds useful as pim kinase inhibitors
TWI734699B (en) 2015-09-09 2021-08-01 美商英塞特公司 Salts of a pim kinase inhibitor
TW201718546A (en) 2015-10-02 2017-06-01 英塞特公司 Heterocyclic compounds useful as PIM kinase inhibitors
US10596161B2 (en) 2017-12-08 2020-03-24 Incyte Corporation Low dose combination therapy for treatment of myeloproliferative neoplasms

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19502912A1 (en) * 1995-01-31 1996-08-01 Hoechst Ag G-Cap Stabilized Oligonucleotides
WO1996039427A1 (en) * 1995-06-05 1996-12-12 Trustees Of Dartmouth College Ligand-stimulated gene expression
NO953680D0 (en) * 1995-09-18 1995-09-18 Hans Prydz Cell cycle Enzymes
EP0911391A3 (en) * 1997-10-24 2000-01-19 Smithkline Beecham Corporation A clone HWHHJ20
US6143540A (en) * 1999-01-26 2000-11-07 Millennium Pharmaceuticals, Inc. Molecules of the HKID-1-related protein family and uses thereof
IL149694A0 (en) * 1999-12-23 2002-11-10 Exiqon As Therapeutic uses of lna-modified oligonucleotides
DE10037759A1 (en) * 2000-08-03 2002-07-04 Gruenenthal Gmbh screening process
DE10123055A1 (en) * 2001-05-11 2003-03-20 Gruenenthal Gmbh Screening method with PIM1-Kinase or PIM3-Kinase

Also Published As

Publication number Publication date
DE10226702A1 (en) 2004-09-09
WO2003106681A3 (en) 2004-07-15
AU2003242678A8 (en) 2003-12-31
WO2003106681A2 (en) 2003-12-24

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase