AU2003237763A1 - Cationic lipids for intracellular delivery of bioactive substances - Google Patents

Cationic lipids for intracellular delivery of bioactive substances

Info

Publication number
AU2003237763A1
AU2003237763A1 AU2003237763A AU2003237763A AU2003237763A1 AU 2003237763 A1 AU2003237763 A1 AU 2003237763A1 AU 2003237763 A AU2003237763 A AU 2003237763A AU 2003237763 A AU2003237763 A AU 2003237763A AU 2003237763 A1 AU2003237763 A1 AU 2003237763A1
Authority
AU
Australia
Prior art keywords
cationic lipids
intracellular delivery
bioactive substances
bioactive
substances
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003237763A
Other languages
English (en)
Inventor
Wen Jie
Kam Leong
Hai Quan Mao
Jun Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johns Hopkins Singapore Pte Ltd
Original Assignee
Johns Hopkins Singapore Pte Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johns Hopkins Singapore Pte Ltd filed Critical Johns Hopkins Singapore Pte Ltd
Publication of AU2003237763A1 publication Critical patent/AU2003237763A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • A61K9/1271Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J51/00Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2003237763A 2002-05-10 2003-05-10 Cationic lipids for intracellular delivery of bioactive substances Abandoned AU2003237763A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37954902P 2002-05-10 2002-05-10
US60/379,549 2002-05-10
PCT/SG2003/000109 WO2003094971A1 (fr) 2002-05-10 2003-05-10 Lipides cationiques pour la liberation intracellulaire de substances bioactives

Publications (1)

Publication Number Publication Date
AU2003237763A1 true AU2003237763A1 (en) 2003-11-11

Family

ID=29420536

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003237763A Abandoned AU2003237763A1 (en) 2002-05-10 2003-05-10 Cationic lipids for intracellular delivery of bioactive substances

Country Status (2)

Country Link
AU (1) AU2003237763A1 (fr)
WO (1) WO2003094971A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8821859B2 (en) * 2004-05-19 2014-09-02 Agency For Science, Technology And Research Methods and articles for the delivery of therapeutic agents
WO2013116126A1 (fr) * 2012-02-01 2013-08-08 Merck Sharp & Dohme Corp. Nouveaux lipides cationiques biodégradables de faible masse moléculaire pour la délivrance d'oligonucléotides

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4391637A (en) * 1981-10-19 1983-07-05 Nl Industries, Inc. Rheological additive for non-aqueous fluid systems
JPH085996B2 (ja) * 1987-07-02 1996-01-24 株式会社ボロンインターナショナル 導電フィルムの製造法
JPH0995471A (ja) * 1995-10-02 1997-04-08 Boron Internatl:Kk カチオン化合物
WO2001091725A2 (fr) * 2000-05-31 2001-12-06 Univ Johns Hopkins Polyphosphates presentant une utilite biologique

Also Published As

Publication number Publication date
WO2003094971A1 (fr) 2003-11-20

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase
TH Corrigenda

Free format text: IN VOL 18, NO 2, PAGE(S) 532 UNDER THE HEADING APPLICATIONS OPI - NAME INDEX UNDER THE NAME JOHNS HOPKINS SINGAPORE PTE LTD, APPLICATION NO. 2003237763, UNDER INID (43) CORRECT THE PUBLICATION DATE TO READ 24.11.2003