AU2002314026A1 - Method for the production of zolpidem - Google Patents

Method for the production of zolpidem

Info

Publication number
AU2002314026A1
AU2002314026A1 AU2002314026A AU2002314026A AU2002314026A1 AU 2002314026 A1 AU2002314026 A1 AU 2002314026A1 AU 2002314026 A AU2002314026 A AU 2002314026A AU 2002314026 A AU2002314026 A AU 2002314026A AU 2002314026 A1 AU2002314026 A1 AU 2002314026A1
Authority
AU
Australia
Prior art keywords
compound
formula
production
zolpidem
coch3
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002314026A
Inventor
Markus Sauter
Wolfgang Wohlleben
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
BOEHRINGER INGELHEIM PHARMA
Boehringer Ingelheim Pharma GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BOEHRINGER INGELHEIM PHARMA, Boehringer Ingelheim Pharma GmbH and Co KG filed Critical BOEHRINGER INGELHEIM PHARMA
Publication of AU2002314026A1 publication Critical patent/AU2002314026A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
    • C07C235/74—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Anesthesiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to a method for the production of a compound of formula (I), wherein a compound of formula (II), in which R<1> represents chlorine, bromine, iodine, -O-COCH3, -tosylate or -mesylate, is reacted with a compound of formula (III), optionally in a suitable diluting agent and/or in the presence of a suitable additional reactant or catalyst, wherein the reaction is carried out at a temperature ranging from 20 to 80 DEG C.
AU2002314026A 2001-05-03 2002-05-02 Method for the production of zolpidem Abandoned AU2002314026A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10121638.6 2001-05-03
DE10121638A DE10121638A1 (en) 2001-05-03 2001-05-03 Process for the preparation of imidazopyridines
PCT/EP2002/004796 WO2002090356A2 (en) 2001-05-03 2002-05-02 Method for the production of zolpidem

Publications (1)

Publication Number Publication Date
AU2002314026A1 true AU2002314026A1 (en) 2002-11-18

Family

ID=7683572

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002314026A Abandoned AU2002314026A1 (en) 2001-05-03 2002-05-02 Method for the production of zolpidem

Country Status (9)

Country Link
EP (1) EP1395586B1 (en)
JP (1) JP2004528380A (en)
AT (1) ATE353896T1 (en)
AU (1) AU2002314026A1 (en)
CA (1) CA2445766A1 (en)
DE (2) DE10121638A1 (en)
ES (1) ES2280550T3 (en)
MX (1) MXPA03010034A (en)
WO (1) WO2002090356A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1370515A2 (en) 2000-08-29 2003-12-17 Ranbaxy Laboratories, Ltd. Synthesis of n,n-dimethyl-3-(4-methyl) benzoyl propionamide, a key intermediate of zolpidem
EP1660496A1 (en) * 2003-07-31 2006-05-31 Ranbaxy Laboratories Limited Process for the synthesis of zolpidem
US20080262025A1 (en) * 2004-07-16 2008-10-23 Yatendra Kumar Processes for the Preparation of Zolpidem and its Hemitartrate
JP2009510163A (en) * 2005-10-03 2009-03-12 マリンクロッド・インコーポレイテッド Process for producing hemitartaric acid and zolpidem tartrate polymorph
AU2007256893A1 (en) * 2006-06-05 2007-12-13 Auspex Pharmaceuticals, Inc. Preparation and utility of substituted imidazopyridine compounds with hypnotic effects
CN110272414B (en) * 2018-03-14 2020-07-17 新发药业有限公司 Preparation method of zolpidem
CN109336756B (en) * 2018-11-20 2021-05-11 河南大学 Hydrogenation dehalogenation method of halogenated aromatic hydrocarbon

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2600650B1 (en) * 1986-06-27 1988-09-09 Synthelabo PROCESS FOR THE PREPARATION OF IMIDAZOPYRIDINES AND INTERMEDIATE COMPOUNDS

Also Published As

Publication number Publication date
DE50209490D1 (en) 2007-03-29
EP1395586B1 (en) 2007-02-14
DE10121638A1 (en) 2002-11-14
MXPA03010034A (en) 2004-02-27
ES2280550T3 (en) 2007-09-16
ATE353896T1 (en) 2007-03-15
JP2004528380A (en) 2004-09-16
WO2002090356A2 (en) 2002-11-14
EP1395586A2 (en) 2004-03-10
CA2445766A1 (en) 2002-11-14
WO2002090356A3 (en) 2003-12-24

Similar Documents

Publication Publication Date Title
WO2003030227A3 (en) Method of semiconductor nanoparticle synthesis
WO2004024777A8 (en) Hydroxyalkyl starch derivatives
WO2002072519A3 (en) Process catalysed by fluoroalkylsulfonated compounds, preferably bis-triflimide compounds
DK1095926T3 (en) Process for the preparation of a 5-phthalanecarbonitrile compound, its intermediate and process for the preparation of the intermediate
IL159931A0 (en) Process for producing pyridine compound
AU2002314026A1 (en) Method for the production of zolpidem
IL168096A (en) Process for the preparation of synthetic intermediate for pesticides
IL182831A0 (en) Method for the production of phthalic dichloride
AU2003207291A1 (en) Process for producing 4-aminoquinazoline compound
IL186979A0 (en) A process for the preparation of pyridine-methylsulfinyl compounds
NZ513551A (en) Novel process for preparing alendronic acid
YU27099A (en) Process and intermediates for the manufacture of pyridine- 2,3-dicarboxylate compounds
PH26289A (en) A process for the preparation of 4-halo-3-halo-3-oxo-2-alkoxy-iminobutyric esters
AU1998701A (en) Process for the preparation of ketimines
WO2000021922A3 (en) Chemical processes
EP1072580A4 (en) Process for producing chloromethylphenylacetic acid
ZA985767B (en) Process for thiolating halobenzoic acid intermediates.
EP0551632A3 (en) Process for the preparation of halogenoanthranilic acid
RU2223945C2 (en) 2-aminobenzophenone production process
AU5983200A (en) Process for preparing betaines
GB0008179D0 (en) Chemical process
EP1258479A3 (en) Process for the production of N,N-carbonyl diimidazole
ID26095A (en) PROCESS OF MAKING BEZOTIOFENKARBOKSAMIDA
WO2000075094A3 (en) Method for producing a halogenated acetophenone
JP2004149515A (en) Method for producing benzothiazole derivative or benzoxazole derivative

Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase