AU2002302409A1 - Insulin preparations, which do not contain any zinc or only a small quantity of zinc and which have an improved stability - Google Patents
Insulin preparations, which do not contain any zinc or only a small quantity of zinc and which have an improved stabilityInfo
- Publication number
- AU2002302409A1 AU2002302409A1 AU2002302409A AU2002302409A AU2002302409A1 AU 2002302409 A1 AU2002302409 A1 AU 2002302409A1 AU 2002302409 A AU2002302409 A AU 2002302409A AU 2002302409 A AU2002302409 A AU 2002302409A AU 2002302409 A1 AU2002302409 A1 AU 2002302409A1
- Authority
- AU
- Australia
- Prior art keywords
- zinc
- contain
- small quantity
- improved stability
- insulin preparations
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 title 2
- 239000011701 zinc Substances 0.000 title 2
- 229910052725 zinc Inorganic materials 0.000 title 2
- 102000004877 Insulin Human genes 0.000 title 1
- 108090001061 Insulin Proteins 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10114178A DE10114178A1 (en) | 2001-03-23 | 2001-03-23 | Zinc-free and low-zinc insulin preparations with improved stability |
DE10114178.5 | 2001-03-23 | ||
PCT/EP2002/002625 WO2002076495A1 (en) | 2001-03-23 | 2002-03-09 | Insulin preparations, which do not contain any zinc or only a small quantity of zinc and which have an improved stability |
Publications (2)
Publication Number | Publication Date |
---|---|
AU2002302409A1 true AU2002302409A1 (en) | 2003-03-27 |
AU2002302409B2 AU2002302409B2 (en) | 2007-01-04 |
Family
ID=7678654
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2002302409A Expired AU2002302409B2 (en) | 2001-03-23 | 2002-03-09 | Insulin preparations, which do not contain any zinc or only a small quantity of zinc and which have an improved stability |
Country Status (32)
Country | Link |
---|---|
US (5) | US6960561B2 (en) |
EP (2) | EP2289539B1 (en) |
JP (1) | JP4231292B2 (en) |
KR (2) | KR100987311B1 (en) |
CN (1) | CN1273187C (en) |
AR (2) | AR033059A1 (en) |
AT (1) | ATE497777T1 (en) |
AU (1) | AU2002302409B2 (en) |
BR (1) | BRPI0208210B8 (en) |
CA (1) | CA2441260C (en) |
CY (2) | CY1111413T1 (en) |
DE (2) | DE10114178A1 (en) |
DK (2) | DK1381385T3 (en) |
ES (2) | ES2393180T3 (en) |
HK (1) | HK1061521A1 (en) |
HR (1) | HRP20030765B1 (en) |
HU (1) | HU228847B1 (en) |
IL (2) | IL158057A0 (en) |
ME (1) | ME00408B (en) |
MX (1) | MXPA03007942A (en) |
MY (1) | MY129417A (en) |
NO (1) | NO326780B1 (en) |
NZ (1) | NZ528335A (en) |
PE (1) | PE20020968A1 (en) |
PL (1) | PL205465B1 (en) |
PT (2) | PT2289539E (en) |
RS (1) | RS51579B (en) |
RU (1) | RU2311922C2 (en) |
SI (1) | SI1381385T1 (en) |
TW (1) | TWI301761B (en) |
WO (1) | WO2002076495A1 (en) |
ZA (1) | ZA200306637B (en) |
Families Citing this family (78)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69834028T2 (en) * | 1997-03-20 | 2006-12-07 | Novo Nordisk A/S | ZINC FREE INSULIN CRYSTALS FOR USE IN MEDICAMENTS DELIVERED BY THE LUNGE. |
DE10114178A1 (en) | 2001-03-23 | 2002-10-10 | Aventis Pharma Gmbh | Zinc-free and low-zinc insulin preparations with improved stability |
US20050250676A1 (en) * | 2001-11-19 | 2005-11-10 | Aventis Pharma Deutschland Gmbh | Method of activating insulin receptor substrate-2 to stimulate insulin production |
DE10227232A1 (en) * | 2002-06-18 | 2004-01-15 | Aventis Pharma Deutschland Gmbh | Sour insulin preparations with improved stability |
US7193035B2 (en) | 2002-10-29 | 2007-03-20 | Sanofi-Aventis Deutschland Gmbh | Crystals of insulin analogs and processes for their preparation |
DE10250297A1 (en) * | 2002-10-29 | 2004-05-19 | Aventis Pharma Deutschland Gmbh | Insulin analog crystals and process for their preparation |
WO2004096266A1 (en) * | 2003-05-02 | 2004-11-11 | Novo Nordisk A/S | Improved physical stability of insulin formulations |
EP1660531A2 (en) | 2003-08-05 | 2006-05-31 | Novo Nordisk A/S | Novel insulin derivatives |
US7658721B2 (en) * | 2004-01-16 | 2010-02-09 | Biodel Inc. | Sublingual drug delivery device |
CA2555921A1 (en) * | 2004-02-13 | 2005-09-15 | Nod Pharmaceuticals, Inc. | Therapeutic calcium phosphate particles and methods of making and using same |
US20080090753A1 (en) | 2004-03-12 | 2008-04-17 | Biodel, Inc. | Rapid Acting Injectable Insulin Compositions |
PL2319500T3 (en) * | 2004-03-12 | 2013-05-31 | Biodel Inc | Rapid acting drug delivery compositions |
US20080096800A1 (en) * | 2004-03-12 | 2008-04-24 | Biodel, Inc. | Rapid mucosal gel or film insulin compositions |
CA2580313C (en) | 2004-07-19 | 2016-03-15 | Biocon Limited | Insulin-oligomer conjugates, formulations and uses thereof |
JP2006087815A (en) * | 2004-09-27 | 2006-04-06 | Canon Inc | Spraying method, and spraying apparatus based on the method |
US20060194762A1 (en) * | 2004-12-23 | 2006-08-31 | Olaf Reer | Composition comprising an epothilone and methods for producing a composition comprising an epothilone |
US8084420B2 (en) | 2005-09-29 | 2011-12-27 | Biodel Inc. | Rapid acting and long acting insulin combination formulations |
US7713929B2 (en) | 2006-04-12 | 2010-05-11 | Biodel Inc. | Rapid acting and long acting insulin combination formulations |
ATE519780T1 (en) * | 2005-12-28 | 2011-08-15 | Novo Nordisk As | COMPOSITIONS CONTAINING ACYLATED INSULIN AND ZINC AND METHOD FOR PRODUCING THESE COMPOSITIONS |
US8927015B2 (en) | 2006-04-12 | 2015-01-06 | Emisphere Technologies, Inc. | Formulations for delivering insulin |
AU2007238114B2 (en) | 2006-04-12 | 2010-10-14 | Biodel, Inc. | Rapid acting and long acting insulin combination formulations |
US7714025B2 (en) * | 2006-05-10 | 2010-05-11 | Arizona Biomedical Research Commission | Modified chalcone compounds as antimitotic agents |
EP2514412A1 (en) * | 2007-04-30 | 2012-10-24 | Novo Nordisk A/S | Highly Concentrated Insulin Solutions and Compositions |
US9034818B2 (en) | 2007-06-13 | 2015-05-19 | Novo Nordisk A/S | Pharmaceutical formulations comprising an insulin derivative |
WO2009065126A2 (en) * | 2007-11-16 | 2009-05-22 | Boston Protein Solutions | Excipients for protein stabilization |
JP2011506442A (en) * | 2007-12-11 | 2011-03-03 | コンジュケム バイオテクノロジーズ インコーポレイテッド | Formulation of insulinotropic peptide conjugate |
DK2229407T3 (en) | 2008-01-09 | 2017-02-27 | Sanofi Aventis Deutschland | NEW INSULIN DERIVATIVES WITH EXTREMELY DELAYED TIME / EFFECTS PROFILE |
KR101239008B1 (en) * | 2008-03-31 | 2013-03-04 | 한양대학교 산학협력단 | Bile acid derivatives and their applications |
JP2010063762A (en) * | 2008-09-12 | 2010-03-25 | Yoshiharu Masui | Antibacterial deodorant |
MX344293B (en) | 2008-10-17 | 2016-12-13 | Sanofi Aventis Deutschland | Combination of an insulin and a glp-1 agonist. |
CN102202683A (en) | 2008-10-30 | 2011-09-28 | 诺沃-诺迪斯克有限公司 | Treating diabetes melitus using insulin injections with less than daily injection frequency |
US9060927B2 (en) | 2009-03-03 | 2015-06-23 | Biodel Inc. | Insulin formulations for rapid uptake |
ES2440289T3 (en) * | 2009-06-26 | 2014-01-28 | Novo Nordisk A/S | Preparation comprising insulin, nicotinamide and arginine |
MY159865A (en) * | 2009-07-06 | 2017-02-15 | Sanofi Aventis Deutschland | Aqueous insulin preparations containing methionine |
BR112012011403B8 (en) | 2009-11-13 | 2021-05-25 | Sanofi Aventis Deutschland | liquid pharmaceutical composition comprising a glp-1 agonist and methionine and use thereof |
PT2498802E (en) | 2009-11-13 | 2015-04-13 | Sanofi Aventis Deutschland | Pharmaceutical composition comprising a glp-1 agonist, an insulin, and methionine |
CN101912600B (en) * | 2010-01-11 | 2014-01-29 | 杨国汉 | Method for improving stability of insulin in solution |
RU2546520C2 (en) | 2010-08-30 | 2015-04-10 | Санофи-Авентис Дойчланд Гмбх | Application of ave0010 for production of medication for treatment of type 2 diabetes mellitus |
BR112013010345A2 (en) | 2010-10-27 | 2017-07-25 | Novo Nordisk As | diabetes mellitus treatment using insulin injections administered at varying injection intervals |
US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
US9408893B2 (en) | 2011-08-29 | 2016-08-09 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for use in glycemic control in diabetes type 2 patients |
TWI559929B (en) | 2011-09-01 | 2016-12-01 | Sanofi Aventis Deutschland | Pharmaceutical composition for use in the treatment of a neurodegenerative disease |
EP2771026A4 (en) | 2011-10-27 | 2015-08-05 | Univ Case Western Reserve | Ultra-concentrated rapid-acting insulin analogue formulations |
PL2919804T3 (en) | 2012-11-13 | 2018-07-31 | Adocia | Quick-acting insulin formulation including a substituted anionic compound |
TWI641381B (en) | 2013-02-04 | 2018-11-21 | 法商賽諾菲公司 | Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives |
CA2907848A1 (en) | 2013-04-03 | 2014-10-09 | Sanofi | Treatment of diabetes mellitus by long-acting formulations of insulins |
EP2991672A1 (en) | 2013-04-30 | 2016-03-09 | Novo Nordisk A/S | Novel administration regime |
TW201605489A (en) * | 2013-10-25 | 2016-02-16 | 賽諾菲公司 | Stable formulation of INSULIN GLULISINE |
WO2015104314A1 (en) | 2014-01-09 | 2015-07-16 | Sanofi | Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives |
SG11201604708VA (en) | 2014-01-09 | 2016-07-28 | Sanofi Sa | Stabilized glycerol free pharmaceutical formulations of insulin analogues and/or insulin derivatives |
CN105899190B (en) | 2014-01-09 | 2022-06-14 | 赛诺菲 | Stabilized pharmaceutical formulations of insulin aspart |
AR099569A1 (en) | 2014-02-28 | 2016-08-03 | Novo Nordisk As | INSULIN DERIVATIVES AND THE MEDICAL USES OF THESE |
US10314911B2 (en) | 2014-04-08 | 2019-06-11 | Healthpartners Research & Education | Methods for protecting and treating traumatic brain injury, concussion and brain inflammation with intranasal insulin |
LT3229828T (en) | 2014-12-12 | 2023-06-12 | Sanofi-Aventis Deutschland Gmbh | Insulin glargine/lixisenatide fixed ratio formulation |
TW201630622A (en) | 2014-12-16 | 2016-09-01 | 美國禮來大藥廠 | Rapid-acting insulin compositions |
TWI748945B (en) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | Treatment type 2 diabetes mellitus patients |
TW201705975A (en) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | Treatment of type 2 diabetes mellitus patients |
AU2016311283B2 (en) | 2015-08-25 | 2020-10-08 | Novo Nordisk A/S | Novel insulin derivatives and the medical uses hereof |
CN108368163A (en) | 2015-08-25 | 2018-08-03 | 诺和诺德股份有限公司 | Novel insulin derivates and its medical usage |
JP2018531901A (en) | 2015-08-25 | 2018-11-01 | ノヴォ ノルディスク アー/エス | Novel insulin derivatives and their medical use |
JO3749B1 (en) | 2015-08-27 | 2021-01-31 | Lilly Co Eli | Rapid-acting insulin compositions |
CN105749292A (en) * | 2016-02-29 | 2016-07-13 | 苏州市贝克生物科技有限公司 | Composition for promoting insulin absorption and preparation method of composition |
GB201607918D0 (en) | 2016-05-06 | 2016-06-22 | Arecor Ltd | Novel formulations |
EP3518892B1 (en) | 2016-09-29 | 2023-06-21 | Arecor Limited | Pharmaceutical formulation comprising an insulin compound |
GB201707189D0 (en) | 2017-05-05 | 2017-06-21 | Arecor Ltd | Novel formulations |
GB201707187D0 (en) | 2017-05-05 | 2017-06-21 | Arecor Ltd | Novel formulations |
GB201707188D0 (en) | 2017-05-05 | 2017-06-21 | Arecor Ltd | Novel formulations |
CN110662551B (en) | 2017-06-01 | 2023-07-18 | 伊莱利利公司 | Quick acting insulin compositions |
WO2019193349A1 (en) | 2018-04-04 | 2019-10-10 | Arecor Limited | Medical infusion pump system for the delivery of an insulin compound |
EP3773474A1 (en) | 2018-04-04 | 2021-02-17 | Arecor Limited | Medical infusion pump system for the delivery of an insulin compound |
WO2019193351A1 (en) | 2018-04-04 | 2019-10-10 | Arecor Limited | Medical infusion pump system for the delivery of an insulin compound |
US10335464B1 (en) | 2018-06-26 | 2019-07-02 | Novo Nordisk A/S | Device for titrating basal insulin |
FR3083700B1 (en) * | 2018-07-13 | 2021-03-12 | Adocia | THERMOSTABLE FORMULATION OF HUMAN INSULIN A21G |
US20220249814A1 (en) | 2018-11-19 | 2022-08-11 | Progenity, Inc. | Methods and devices for treating a disease with biotherapeutics |
WO2021081404A1 (en) | 2019-10-25 | 2021-04-29 | Cercacor Laboratories, Inc. | Indicator compounds, devices comprising indicator compounds, and methods of making and using the same |
CN114787184A (en) | 2019-12-11 | 2022-07-22 | 诺和诺德股份有限公司 | Novel insulin analogs and uses thereof |
WO2021119482A1 (en) | 2019-12-13 | 2021-06-17 | Progenity, Inc. | Ingestible device for delivery of therapeutic agent to the gastrointestinal tract |
GB202004814D0 (en) | 2020-04-01 | 2020-05-13 | Arecor Ltd | Novel formulations |
Family Cites Families (101)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3868358A (en) | 1971-04-30 | 1975-02-25 | Lilly Co Eli | Protamine-insulin product |
US3758683A (en) | 1971-04-30 | 1973-09-11 | R Jackson | Insulin product |
US4153689A (en) * | 1975-06-13 | 1979-05-08 | Takeda Chemical Industries, Ltd. | Stable insulin preparation for nasal administration |
GB1527605A (en) | 1975-08-20 | 1978-10-04 | Takeda Chemical Industries Ltd | Insulin preparation for intranasal administration |
US4783441A (en) | 1979-04-30 | 1988-11-08 | Hoechst Aktiengesellschaft | Aqueous protein solutions stable to denaturation |
DE3064888D1 (en) | 1979-04-30 | 1983-10-27 | Hoechst Ag | Aqueous solutions of proteins stable against denaturization, process for their manufacture, and their utilization |
JPS55153712A (en) | 1979-05-18 | 1980-11-29 | Kao Corp | Insulin pharmaceutical preparation and its production |
DE3033127A1 (en) | 1980-09-03 | 1982-04-08 | Hoechst Ag, 6000 Frankfurt | NEW INSULIN ANALOG |
AU558474B2 (en) | 1981-07-17 | 1987-01-29 | Nordisk Insulinlaboratorium | A stable aqueous, therapeutic insulin preparation and a process for preparing it |
NL193099C (en) | 1981-10-30 | 1998-11-03 | Novo Industri As | Stabilized insulin solution. |
DE3316363A1 (en) | 1983-05-05 | 1984-11-08 | Deutsche Babcock Anlagen Ag, 4200 Oberhausen | ROLLER GRID FOR WASTE COMBUSTION PLANTS |
DE3326472A1 (en) | 1983-07-22 | 1985-02-14 | Hoechst Ag, 6230 Frankfurt | NEW INSULIN DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF AND PHARMACEUTICAL AGENTS FOR TREATING THE DIABETES MELLITUS |
DE3326473A1 (en) | 1983-07-22 | 1985-01-31 | Hoechst Ag, 6230 Frankfurt | PHARMACEUTICAL AGENT FOR TREATING THE DIABETES MELLITUS |
DE3327709A1 (en) | 1983-07-29 | 1985-02-07 | Hoechst Ag, 6230 Frankfurt | INSULIN DERIVATIVE CRYSTAL SUSPENSIONS, METHOD FOR THE PRODUCTION AND USE THEREOF |
DE3327713A1 (en) | 1983-07-29 | 1985-02-07 | Hoechst Ag, 6230 Frankfurt | WATER-SOLUBLE DISAZO COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS DYES |
CA1244347A (en) * | 1984-05-29 | 1988-11-08 | Eddie H. Massey | Stabilized insulin formulations |
US4839341A (en) | 1984-05-29 | 1989-06-13 | Eli Lilly And Company | Stabilized insulin formulations |
ATE50502T1 (en) | 1984-06-09 | 1990-03-15 | Hoechst Ag | INSULIN PREPARATIONS, PROCESSES FOR THEIR MANUFACTURE AND THEIR USE. |
KR860001166B1 (en) * | 1984-06-15 | 1986-08-20 | 곽성일 | A method of manufacturing eyelets for footwears |
DE3440988A1 (en) | 1984-11-09 | 1986-07-10 | Hoechst Ag, 6230 Frankfurt | METHOD FOR CLEAVING PEPTIDES AND PROTEINS ON THE METHIONYL BOND |
US5008241A (en) | 1985-03-12 | 1991-04-16 | Novo Nordisk A/S | Novel insulin peptides |
DK347086D0 (en) | 1986-07-21 | 1986-07-21 | Novo Industri As | NOVEL PEPTIDES |
DK113585D0 (en) | 1985-03-12 | 1985-03-12 | Novo Industri As | NEW PEPTIDES |
IL78425A (en) * | 1985-04-15 | 1991-05-12 | Lilly Co Eli | Intranasal formulation containing insulin |
DE3526995A1 (en) | 1985-07-27 | 1987-02-05 | Hoechst Ag | FUSION PROTEINS, METHOD FOR THEIR PRODUCTION AND THEIR USE |
PH25772A (en) | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
DE3541856A1 (en) | 1985-11-27 | 1987-06-04 | Hoechst Ag | EUKARYOTIC FUSION PROTEINS, THEIR PRODUCTION AND USE, AND MEANS FOR CARRYING OUT THE PROCESS |
US5496924A (en) | 1985-11-27 | 1996-03-05 | Hoechst Aktiengesellschaft | Fusion protein comprising an interleukin-2 fragment ballast portion |
CA1275922C (en) | 1985-11-28 | 1990-11-06 | Harunobu Amagase | Treatment of cancer |
DE3544295A1 (en) | 1985-12-14 | 1987-06-19 | Bayer Ag | THERMOPLASTIC MOLDS WITH HIGH CROSS-CURRENT RESISTANCE |
PH23446A (en) | 1986-10-20 | 1989-08-07 | Novo Industri As | Peptide preparations |
JP2606915B2 (en) | 1987-02-25 | 1997-05-07 | ノボ ノルディスク アクティーゼルスカブ | New insulin derivatives |
US5034415A (en) | 1987-08-07 | 1991-07-23 | Century Laboratories, Inc. | Treatment of diabetes mellitus |
DE3726655A1 (en) | 1987-08-11 | 1989-02-23 | Hoechst Ag | METHOD FOR ISOLATING BASIC PROTEINS FROM PROTEIN MIXTURES CONTAINING SUCH BASIC PROTEINS |
DK257988D0 (en) | 1988-05-11 | 1988-05-11 | Novo Industri As | NEW PEPTIDES |
US6875589B1 (en) | 1988-06-23 | 2005-04-05 | Hoechst Aktiengesellschaft | Mini-proinsulin, its preparation and use |
DE3827533A1 (en) | 1988-08-13 | 1990-02-15 | Hoechst Ag | PHARMACEUTICAL PREPARATION FOR TREATING THE DIABETES MELLITUS |
DE3837825A1 (en) | 1988-11-08 | 1990-05-10 | Hoechst Ag | NEW INSULIN DERIVATIVES, THEIR USE AND A PHARMACEUTICAL PREPARATION CONTAINING THEM |
KR910700262A (en) | 1988-12-23 | 1991-03-14 | 안네 제케르 | Human insulin analogues |
US4994439A (en) | 1989-01-19 | 1991-02-19 | California Biotechnology Inc. | Transmembrane formulations for drug administration |
PT93057B (en) | 1989-02-09 | 1995-12-29 | Lilly Co Eli | PROCESS FOR THE PREPARATION OF INSULIN ANALOGS |
US5514646A (en) | 1989-02-09 | 1996-05-07 | Chance; Ronald E. | Insulin analogs modified at position 29 of the B chain |
US5358857A (en) | 1989-08-29 | 1994-10-25 | The General Hospital Corp. | Method of preparing fusion proteins |
WO1991016929A1 (en) | 1990-05-10 | 1991-11-14 | Novo Nordisk A/S | A pharmaceutical preparation containing n-glycofurols and n-ethylene glycols |
US5397771A (en) | 1990-05-10 | 1995-03-14 | Bechgaard International Research And Development A/S | Pharmaceutical preparation |
DK155690D0 (en) | 1990-06-28 | 1990-06-28 | Novo Nordisk As | NEW PEPTIDES |
DK10191D0 (en) | 1991-01-22 | 1991-01-22 | Novo Nordisk As | HIS UNKNOWN PEPTIDES |
DE59206324D1 (en) | 1991-12-05 | 1996-06-20 | Alfatec Pharma Gmbh | PHARMACEUTICAL APPLICABLE NANOSOL AND METHOD FOR THE PRODUCTION THEREOF |
US6468959B1 (en) | 1991-12-05 | 2002-10-22 | Alfatec-Pharm Gmbh | Peroral dosage form for peptide containing medicaments, in particular insulin |
US5614219A (en) | 1991-12-05 | 1997-03-25 | Alfatec-Pharma Gmbh | Oral administration form for peptide pharmaceutical substances, in particular insulin |
ES2097426T3 (en) | 1992-12-02 | 1997-04-01 | Hoechst Ag | PROCEDURE FOR OBTAINING PROINSULIN WITH CORRECTLY UNITED CYSTINE BRIDGES. |
PL310007A1 (en) | 1992-12-18 | 1995-11-13 | Lilly Co Eli | Insulin analogues |
DE4400709B4 (en) * | 1993-01-13 | 2005-06-23 | Denso Corp., Kariya | Screw fastening device |
US5606203A (en) * | 1993-01-20 | 1997-02-25 | Kabushiki Kaisha Toshiba | Semiconductor device having Al-Cu wiring lines where Cu concentration is related to line width |
US5506203C1 (en) * | 1993-06-24 | 2001-02-06 | Astra Ab | Systemic administration of a therapeutic preparation |
US5534488A (en) | 1993-08-13 | 1996-07-09 | Eli Lilly And Company | Insulin formulation |
DE4405179A1 (en) | 1994-02-18 | 1995-08-24 | Hoechst Ag | Method of obtaining insulin with correctly connected cystine bridges |
US5474978A (en) | 1994-06-16 | 1995-12-12 | Eli Lilly And Company | Insulin analog formulations |
US5559094A (en) | 1994-08-02 | 1996-09-24 | Eli Lilly And Company | AspB1 insulin analogs |
ATE197398T1 (en) | 1994-09-09 | 2000-11-11 | Takeda Chemical Industries Ltd | DELAYED RELEASE PREPARATION OF A METAL SALT OF A PEPTIDE |
US5547929A (en) | 1994-09-12 | 1996-08-20 | Eli Lilly And Company | Insulin analog formulations |
US5707641A (en) | 1994-10-13 | 1998-01-13 | Pharmaderm Research & Development Ltd. | Formulations comprising therapeutically-active proteins or polypeptides |
US5824638A (en) | 1995-05-22 | 1998-10-20 | Shire Laboratories, Inc. | Oral insulin delivery |
WO1996041606A2 (en) | 1995-06-08 | 1996-12-27 | Therexsys Limited | Improved pharmaceutical compositions for gene therapy |
AU6242096A (en) | 1995-06-27 | 1997-01-30 | Takeda Chemical Industries Ltd. | Method of producing sustained-release preparation |
DE19545257A1 (en) | 1995-11-24 | 1997-06-19 | Schering Ag | Process for the production of morphologically uniform microcapsules and microcapsules produced by this process |
US5985309A (en) | 1996-05-24 | 1999-11-16 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
US5948751A (en) | 1996-06-20 | 1999-09-07 | Novo Nordisk A/S | X14-mannitol |
US5866538A (en) | 1996-06-20 | 1999-02-02 | Novo Nordisk A/S | Insulin preparations containing NaCl |
US5783556A (en) | 1996-08-13 | 1998-07-21 | Genentech, Inc. | Formulated insulin-containing composition |
DE19707245A1 (en) * | 1997-02-25 | 1998-08-27 | Patent Treuhand Ges Fuer Elektrische Gluehlampen Mbh | Method of making an electric light bulb |
DE69834028T2 (en) * | 1997-03-20 | 2006-12-07 | Novo Nordisk A/S | ZINC FREE INSULIN CRYSTALS FOR USE IN MEDICAMENTS DELIVERED BY THE LUNGE. |
US6043214A (en) | 1997-03-20 | 2000-03-28 | Novo Nordisk A/S | Method for producing powder formulation comprising an insulin |
US6310038B1 (en) | 1997-03-20 | 2001-10-30 | Novo Nordisk A/S | Pulmonary insulin crystals |
CO4750643A1 (en) | 1997-06-13 | 1999-03-31 | Lilly Co Eli | STABLE FORMULATION OF INSULIN CONTAINING L-ARGININ AND PROTAMINE |
DE19726167B4 (en) | 1997-06-20 | 2008-01-24 | Sanofi-Aventis Deutschland Gmbh | Insulin, process for its preparation and pharmaceutical preparation containing it |
ZA989744B (en) | 1997-10-31 | 2000-04-26 | Lilly Co Eli | Method for administering acylated insulin. |
ES2230727T3 (en) | 1997-11-12 | 2005-05-01 | Alza Corporation | PROCEDURE FOR DERMAL POLIPEPTIDE ADMINISTRATION. |
EP1044016B1 (en) | 1998-01-09 | 2005-03-16 | Novo Nordisk A/S | Stabilised insulin compositions |
US6635617B1 (en) | 1998-10-16 | 2003-10-21 | Novo Nordisk A/S | Insulin preparations for pulmonary delivery containing menthol |
US6211144B1 (en) * | 1998-10-16 | 2001-04-03 | Novo Nordisk A/S | Stable concentrated insulin preparations for pulmonary delivery |
JP2002527488A (en) | 1998-10-16 | 2002-08-27 | ノボ ノルディスク アクティーゼルスカブ | Insulin formulation for pulmonary delivery containing menthol |
UA65636C2 (en) | 1998-10-16 | 2004-04-15 | Ново Нордіск А/С | Concentrated aqueous insulin formulations of high stability suitable for pulmonary delivery |
US6489292B1 (en) | 1998-11-18 | 2002-12-03 | Novo Nordisk A/S | Stable aqueous insulin preparations without phenol and cresol |
DE69914934T2 (en) | 1998-11-18 | 2005-01-05 | Novo Nordisk A/S | STABLE, AQUEOUS INSULIN PREPARATIONS WITHOUT PHENOL AND CRESOL |
DE19908041A1 (en) * | 1999-02-24 | 2000-08-31 | Hoecker Hartwig | Covalently bridged insulin dimers |
US6248363B1 (en) | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
JP2003501404A (en) * | 1999-06-04 | 2003-01-14 | デルルックス ファーマシューティカル コーポレイション | Preparation comprising dehydrated particles of drug and method of preparing same |
AU5760900A (en) | 1999-06-25 | 2001-01-31 | Minimed, Inc. | Multiple agent diabetes therapy |
US6309663B1 (en) | 1999-08-17 | 2001-10-30 | Lipocine Inc. | Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents |
CN1174741C (en) | 1999-09-21 | 2004-11-10 | Rtp药品公司 | Surface modified particulate compositions of biologically active substances |
US6720001B2 (en) | 1999-10-18 | 2004-04-13 | Lipocine, Inc. | Emulsion compositions for polyfunctional active ingredients |
WO2001052937A1 (en) | 2000-01-24 | 2001-07-26 | Medtronic Minimed, Inc. | Mixed buffer system for stabilizing polypeptide formulations |
AU2001264789A1 (en) | 2000-06-08 | 2001-12-17 | Eli Lilly And Company | Protein powder for pulmonary delivery |
KR100508695B1 (en) | 2001-02-13 | 2005-08-17 | 한국과학기술연구원 | Formulation for oral delivery of insulin and preparation method thereof |
DE10114178A1 (en) * | 2001-03-23 | 2002-10-10 | Aventis Pharma Gmbh | Zinc-free and low-zinc insulin preparations with improved stability |
CN1160122C (en) | 2001-04-20 | 2004-08-04 | 清华大学 | Method of preparing oil-phase oral insulin preparation |
US20040265268A1 (en) | 2001-08-18 | 2004-12-30 | Deepak Jain | Compositions and methods for skin rejuvenation and repair |
US20050123509A1 (en) | 2001-10-19 | 2005-06-09 | Lehrman S. R. | Modulating charge density to produce improvements in the characteristics of spray-dried proteins |
US20050013867A1 (en) | 2001-10-19 | 2005-01-20 | Lehrman S. Russ | Use of proton sequestering agents in drug formulations |
US20060287221A1 (en) | 2003-11-13 | 2006-12-21 | Novo Nordisk A/S | Soluble pharmaceutical compositions for parenteral administration comprising a GLP-1 peptide and an insulin peptide of short time action for treatment of diabetes and bulimia |
-
2001
- 2001-03-23 DE DE10114178A patent/DE10114178A1/en not_active Ceased
-
2002
- 2002-03-09 EP EP10178836A patent/EP2289539B1/en not_active Expired - Lifetime
- 2002-03-09 PT PT10178836T patent/PT2289539E/en unknown
- 2002-03-09 AT AT02729985T patent/ATE497777T1/en active
- 2002-03-09 DK DK02729985.8T patent/DK1381385T3/en active
- 2002-03-09 RS YU73503A patent/RS51579B/en unknown
- 2002-03-09 JP JP2002575008A patent/JP4231292B2/en not_active Expired - Lifetime
- 2002-03-09 CA CA2441260A patent/CA2441260C/en not_active Expired - Lifetime
- 2002-03-09 ME MEP-2008-608A patent/ME00408B/en unknown
- 2002-03-09 KR KR1020037012339A patent/KR100987311B1/en active IP Right Grant
- 2002-03-09 RU RU2003131187/15A patent/RU2311922C2/en active
- 2002-03-09 DE DE50214903T patent/DE50214903D1/en not_active Expired - Lifetime
- 2002-03-09 SI SI200230934T patent/SI1381385T1/en unknown
- 2002-03-09 EP EP02729985A patent/EP1381385B1/en not_active Expired - Lifetime
- 2002-03-09 IL IL15805702A patent/IL158057A0/en unknown
- 2002-03-09 DK DK10178836.2T patent/DK2289539T3/en active
- 2002-03-09 NZ NZ528335A patent/NZ528335A/en not_active IP Right Cessation
- 2002-03-09 BR BR0208210-1 patent/BRPI0208210B8/en not_active IP Right Cessation
- 2002-03-09 WO PCT/EP2002/002625 patent/WO2002076495A1/en active Application Filing
- 2002-03-09 ES ES10178836T patent/ES2393180T3/en not_active Expired - Lifetime
- 2002-03-09 PT PT02729985T patent/PT1381385E/en unknown
- 2002-03-09 CN CNB02807114XA patent/CN1273187C/en not_active Expired - Lifetime
- 2002-03-09 MX MXPA03007942A patent/MXPA03007942A/en active IP Right Grant
- 2002-03-09 ES ES02729985T patent/ES2360505T3/en not_active Expired - Lifetime
- 2002-03-09 AU AU2002302409A patent/AU2002302409B2/en not_active Expired
- 2002-03-09 PL PL362800A patent/PL205465B1/en unknown
- 2002-03-09 KR KR1020107011428A patent/KR20100061868A/en not_active Application Discontinuation
- 2002-03-09 HU HU0303596A patent/HU228847B1/en unknown
- 2002-03-21 AR ARP020101020A patent/AR033059A1/en not_active Application Discontinuation
- 2002-03-21 TW TW091105385A patent/TWI301761B/en not_active IP Right Cessation
- 2002-03-22 PE PE2002000226A patent/PE20020968A1/en not_active Application Discontinuation
- 2002-03-22 US US10/102,862 patent/US6960561B2/en not_active Expired - Lifetime
- 2002-03-22 MY MYPI20021031A patent/MY129417A/en unknown
-
2003
- 2003-08-26 ZA ZA200306637A patent/ZA200306637B/en unknown
- 2003-09-16 NO NO20034125A patent/NO326780B1/en not_active IP Right Cessation
- 2003-09-22 IL IL158057A patent/IL158057A/en active IP Right Grant
- 2003-09-22 HR HR20030765A patent/HRP20030765B1/en not_active IP Right Cessation
-
2004
- 2004-06-19 HK HK04104454A patent/HK1061521A1/en not_active IP Right Cessation
- 2004-12-09 US US11/007,154 patent/US7205276B2/en not_active Expired - Lifetime
- 2004-12-09 US US11/007,155 patent/US7205277B2/en not_active Expired - Lifetime
-
2007
- 2007-03-08 US US11/683,747 patent/US7452860B2/en not_active Expired - Lifetime
-
2008
- 2008-10-06 US US12/285,464 patent/US7696162B2/en not_active Expired - Lifetime
-
2011
- 2011-03-03 CY CY20111100253T patent/CY1111413T1/en unknown
-
2012
- 2012-11-08 CY CY20121101060T patent/CY1113318T1/en unknown
-
2014
- 2014-05-21 AR ARP140102020A patent/AR096376A2/en not_active Application Discontinuation
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU2002302409A1 (en) | Insulin preparations, which do not contain any zinc or only a small quantity of zinc and which have an improved stability | |
HUP0303596A3 (en) | Insulin preparations, which do not contain any zinc or only a small quantity of zinc and which have an improved stability | |
AU2002248464A1 (en) | Stabilized insulin formulations | |
AU2002352344A1 (en) | Medicament delivery assembly | |
AU1409801A (en) | Powder inhaler | |
AU2002343711A1 (en) | Syringe bandolier with control feature | |
AU2001278142A1 (en) | Common application metamodel including c/c++ metamodel | |
AU2001243567A1 (en) | Stent having cover with drug delivery capability | |
AU2001247360A1 (en) | Stent having cover with drug delivery capability | |
AU2002366042A1 (en) | Solid dispersions containing substituted cyclodextrin and insoluble drug and their preparations | |
AU2002338529A1 (en) | Biological pacemaker | |
AU2001236018A1 (en) | Prefilled syringe assembly | |
AU2002215772A1 (en) | Implantable neurostimulator | |
AU2002359919A1 (en) | Syringe | |
AUPR419701A0 (en) | An improved backpack | |
AU2002329989A1 (en) | Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same | |
AU2002361092A1 (en) | Syringe | |
AU2002363359A1 (en) | Infusion pump | |
AU2002359921A1 (en) | Prefilled syringe | |
AU2001258550A1 (en) | Insulin formulation for inhalation | |
AU2002240004A1 (en) | Infusion cannula | |
AU2002255549A1 (en) | 23565, a novel human zinc carboxypeptidase family member and uses thereof | |
AU2001268560A1 (en) | Information delivery system for application when time is of the essence | |
AU2002219710A1 (en) | Assembly of a cup and a stirring element, as well as a cup and a stirring element intended for such an assembly | |
AU2002349142A1 (en) | Syringe |