AU2002235126A1 - Novel polyamine analog-amino acid conjugates useful as anticancer agents - Google Patents

Novel polyamine analog-amino acid conjugates useful as anticancer agents

Info

Publication number
AU2002235126A1
AU2002235126A1 AU2002235126A AU3512602A AU2002235126A1 AU 2002235126 A1 AU2002235126 A1 AU 2002235126A1 AU 2002235126 A AU2002235126 A AU 2002235126A AU 3512602 A AU3512602 A AU 3512602A AU 2002235126 A1 AU2002235126 A1 AU 2002235126A1
Authority
AU
Australia
Prior art keywords
amino acid
anticancer agents
acid conjugates
polyamine analog
conjugates useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002235126A
Inventor
Benjamin Frydman
Laurence J. Marton
Venodhar K. Reddy
Aldonia L. Valasinas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SLIL Biomedical Corp
Original Assignee
SLIL Biomedical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SLIL Biomedical Corp filed Critical SLIL Biomedical Corp
Publication of AU2002235126A1 publication Critical patent/AU2002235126A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/10—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
AU2002235126A 2000-11-08 2001-11-08 Novel polyamine analog-amino acid conjugates useful as anticancer agents Abandoned AU2002235126A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24680400P 2000-11-08 2000-11-08
US60/246,804 2000-11-08
PCT/US2001/043585 WO2002038105A2 (en) 2000-11-08 2001-11-08 Novel polyamine analog-amino acid conjugates useful as anticancer agents

Publications (1)

Publication Number Publication Date
AU2002235126A1 true AU2002235126A1 (en) 2002-05-21

Family

ID=22932280

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2001297817A Abandoned AU2001297817A1 (en) 2000-11-08 2001-11-08 Antiviral therapies using polyamine or polyamine analog-amino acid conjugates
AU2002235126A Abandoned AU2002235126A1 (en) 2000-11-08 2001-11-08 Novel polyamine analog-amino acid conjugates useful as anticancer agents

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AU2001297817A Abandoned AU2001297817A1 (en) 2000-11-08 2001-11-08 Antiviral therapies using polyamine or polyamine analog-amino acid conjugates

Country Status (5)

Country Link
US (1) US7312244B2 (en)
EP (1) EP1337504A4 (en)
JP (1) JP2004513136A (en)
AU (2) AU2001297817A1 (en)
WO (2) WO2002038105A2 (en)

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US7312244B2 (en) 2007-12-25
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WO2002091989A2 (en) 2002-11-21
WO2002091989A3 (en) 2004-02-19
US20040133013A1 (en) 2004-07-08
EP1337504A2 (en) 2003-08-27
AU2001297817A1 (en) 2002-11-25
WO2002038105A3 (en) 2003-02-27
EP1337504A4 (en) 2005-10-05

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