JP4213586B2
(en)
|
2001-09-13 |
2009-01-21 |
株式会社抗体研究所 |
Camel antibody library production method
|
JP2005289809A
(en)
|
2001-10-24 |
2005-10-20 |
Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) |
Mutant heavy-chain antibody
|
EP1517921B1
(en)
|
2002-06-28 |
2006-06-07 |
Domantis Limited |
Dual specific ligands with increased serum half-life
|
WO2005003326A2
(en)
*
|
2003-03-28 |
2005-01-13 |
Receptors Llc. |
Artificial receptors including reversibly immobilized building blocks and methods
|
US20060034845A1
(en)
|
2002-11-08 |
2006-02-16 |
Karen Silence |
Single domain antibodies directed against tumor necrosis factor alpha and uses therefor
|
US9320792B2
(en)
|
2002-11-08 |
2016-04-26 |
Ablynx N.V. |
Pulmonary administration of immunoglobulin single variable domains and constructs thereof
|
WO2004041862A2
(en)
|
2002-11-08 |
2004-05-21 |
Ablynx N.V. |
Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor
|
US20060024746A1
(en)
*
|
2004-07-14 |
2006-02-02 |
Artann Laboratories, Inc. |
Methods and devices for optical monitoring and rapid analysis of drying droplets
|
US7563443B2
(en)
|
2004-09-17 |
2009-07-21 |
Domantis Limited |
Monovalent anti-CD40L antibody polypeptides and compositions thereof
|
WO2006055371A2
(en)
*
|
2004-11-16 |
2006-05-26 |
Alexion Pharmaceuticals, Inc. |
Functional screening of antibody libraries
|
FR2879605B1
(en)
*
|
2004-12-16 |
2008-10-17 |
Centre Nat Rech Scient Cnrse |
PRODUCTION OF ANTIBODY FORMATS AND IMMUNOLOGICAL APPLICATIONS OF THESE FORMATS
|
US7883858B2
(en)
*
|
2005-01-27 |
2011-02-08 |
Institute For Systems Biology |
Methods for identifying and monitoring drug side effects
|
WO2006122787A1
(en)
|
2005-05-18 |
2006-11-23 |
Ablynx Nv |
Serum albumin binding proteins
|
KR101414438B1
(en)
|
2005-05-20 |
2014-07-10 |
아블린쓰 엔.브이. |
Single domain vhh antibodies against von willebrand factor
|
DE102005023617A1
(en)
|
2005-05-21 |
2006-11-23 |
Aspre Ag |
Method for mixing colors in a display
|
EP3028716B1
(en)
|
2006-10-10 |
2020-09-16 |
Regenesance B.V. |
Complement inhibition for improved nerve regeneration
|
WO2008074840A2
(en)
|
2006-12-19 |
2008-06-26 |
Ablynx N.V. |
Amino acid sequences directed against a metalloproteinase from the adam family and polypeptides comprising the same for the treatment of adam-related diseases and disorders
|
EP2557090A3
(en)
|
2006-12-19 |
2013-05-29 |
Ablynx N.V. |
Amino acid sequences directed against GPCRs and polypeptides comprising the same for the treatment of GPCR-related diseases and disorders
|
US9023352B2
(en)
|
2007-02-20 |
2015-05-05 |
Tufts University |
Methods, compositions and kits for treating a subject using a recombinant heteromultimeric neutralizing binding protein
|
WO2008118013A2
(en)
|
2007-03-23 |
2008-10-02 |
To-Bbb Holding B.V. |
Targeted intracellular delivery of antiviral agents
|
CA2691940C
(en)
|
2007-07-03 |
2018-03-06 |
Joost Alexander Kolkman |
Methods for providing improved immunoglobulin sequences
|
CA2694737C
(en)
|
2007-07-13 |
2019-05-14 |
Bac Ip B.V. |
Single-domain antigen-binding proteins that bind mammalian igg
|
AU2007358569B2
(en)
*
|
2007-09-07 |
2014-09-04 |
Ablynx N.V. |
Binding molecules with multiple binding sites, compositions comprising the same and uses thereof
|
US20090305899A1
(en)
*
|
2007-11-16 |
2009-12-10 |
Invitrogen Incorporated |
Compositions and methods for determining immune status
|
BRPI0819656A2
(en)
|
2007-11-27 |
2015-06-23 |
Ablynx Nv |
Amino acid sequences against heterodimeric cytokines and / or their receptors and polypeptides comprising the same
|
EP2247616A2
(en)
|
2008-03-05 |
2010-11-10 |
Ablynx N.V. |
Novel antigen binding dimer-complexes, methods of making and uses thereof
|
EP2260058A2
(en)
|
2008-04-07 |
2010-12-15 |
Ablynx N.V. |
Single variable domains against the notch pathways
|
US8217140B2
(en)
|
2008-04-17 |
2012-07-10 |
Ablynx N.V. |
Peptides capable of binding to serum proteins and compounds, constructs and polypeptides comprising the same
|
WO2010056550A1
(en)
|
2008-10-29 |
2010-05-20 |
Wyeth Llc |
Methods for purification of single domain antigen binding molecules
|
EP3011953A1
(en)
|
2008-10-29 |
2016-04-27 |
Ablynx N.V. |
Stabilised formulations of single domain antigen binding molecules
|
EP2403873A1
(en)
|
2009-03-05 |
2012-01-11 |
Ablynx N.V. |
Novel antigen binding dimer-complexes, methods of making/avoiding and uses thereof
|
EP2982690B1
(en)
|
2009-04-30 |
2021-01-27 |
Ablynx N.V. |
Method for the production of domain antibodies
|
HUE051430T2
(en)
|
2009-07-10 |
2021-03-01 |
Ablynx Nv |
Method for the production of variable domains
|
EP3438126B1
(en)
|
2009-09-03 |
2020-08-19 |
Ablynx N.V. |
Stable formulations of polypeptides and uses thereof
|
WO2011083141A2
(en)
|
2010-01-08 |
2011-07-14 |
Ablynx Nv |
Method for generation of immunoglobulin sequences by using lipoprotein particles
|
EP2531523A1
(en)
|
2010-02-05 |
2012-12-12 |
Ablynx N.V. |
Peptides capable of binding to serum albumin and compounds, constructs and polypeptides comprising the same
|
PL2533761T3
(en)
|
2010-02-11 |
2019-09-30 |
Ablynx N.V. |
Methods and compositions for the preparation of aerosols
|
US9556273B2
(en)
|
2010-03-29 |
2017-01-31 |
Vib Vzw |
Anti-macrophage mannose receptor single variable domains for targeting and in vivo imaging of tumor-associated macrophages
|
US9101674B2
(en)
|
2010-03-29 |
2015-08-11 |
Vib Vzw |
Targeting and in vivo imaging of tumor-associated macrophages
|
WO2011161263A1
(en)
|
2010-06-25 |
2011-12-29 |
Ablynx Nv |
Pharmaceutical compositions for cutaneous administration
|
WO2012056000A1
(en)
|
2010-10-29 |
2012-05-03 |
Ablynx Nv |
Method for the production of immunoglobulin single variable domains
|
US9850315B2
(en)
*
|
2011-02-01 |
2017-12-26 |
Bac Ip B.V. |
Antigen-binding protein directed against epitope in the CH1 domain of human IgG antibodies
|
PT2691415T
(en)
|
2011-03-28 |
2018-10-19 |
Ablynx Nv |
Method for producing solid formulations comprising immunoglobulin single variable domains
|
EP2707382B1
(en)
|
2011-05-09 |
2019-07-17 |
Ablynx NV |
Method for the production of immunoglobulin single variable domains
|
RU2661677C2
(en)
|
2011-05-27 |
2018-07-18 |
Аблинкс Нв |
Inhibition of bone resorption with rank-l binding peptides
|
CN104271598A
(en)
|
2011-06-23 |
2015-01-07 |
埃博灵克斯股份有限公司 |
Immunoglobulin single variable domains directed against IgE
|
WO2013041901A1
(en)
*
|
2011-09-20 |
2013-03-28 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for preparing single domain antibody microarrays
|
EP3311837A1
(en)
|
2011-09-23 |
2018-04-25 |
Ablynx NV |
Prolonged inhibition of interleukin-6 mediated signaling
|
US10112988B2
(en)
|
2012-01-09 |
2018-10-30 |
Icb International, Inc. |
Methods of assessing amyloid-beta peptides in the central nervous system by blood-brain barrier permeable peptide compositions comprising a vab domain of a camelid single domain heavy chain antibody against an anti-amyloid-beta peptide
|
US10112987B2
(en)
|
2012-01-09 |
2018-10-30 |
Icb International, Inc. |
Blood-brain barrier permeable peptide compositions comprising a vab domain of a camelid single domain heavy chain antibody against an amyloid-beta peptide
|
JP6411333B2
(en)
|
2012-05-24 |
2018-10-24 |
ブイアイビー ブイゼットダブリュVib Vzw |
Anti-macrophage mannose receptor single variable domain for tumor-associated macrophage targeting and INVIVO imaging
|
US20140046722A1
(en)
*
|
2012-08-10 |
2014-02-13 |
Sample6 Technologies, Inc. |
System for on-site environment monitoring
|
WO2014087010A1
(en)
|
2012-12-07 |
2014-06-12 |
Ablynx N.V. |
IMPROVED POLYPEPTIDES DIRECTED AGAINST IgE
|
JP6443344B2
(en)
|
2013-01-30 |
2018-12-26 |
フエー・イー・ベー・フエー・ゼツト・ウエー |
Novel chimeric polypeptides for screening and drug development
|
PT2953973T
(en)
|
2013-02-05 |
2019-10-25 |
Univ Brussel Vrije |
Muscarinic acetylcholine receptor binding agents and uses thereof
|
CA2906259C
(en)
|
2013-03-15 |
2022-12-06 |
Vib Vzw |
Anti-mmr single variable domains for prognosis and monitoring of cardiovascular diseases
|
PL2992101T3
(en)
|
2013-04-29 |
2019-05-31 |
Agrosavfe Nv |
Agrochemical compositions comprising antibodies binding to sphingolipids
|
NL1040254C2
(en)
|
2013-05-17 |
2014-11-24 |
Ablynx Nv |
Stable formulations of immunoglobulin single variable domains and uses thereof.
|
FR3007411B1
(en)
*
|
2013-06-21 |
2015-07-03 |
Agronomique Inst Nat Rech |
MONOCATENARY ANTIBODY TO CAMPHIDE HEAVY CHAIN AGAINST CHROMATIN AND USES THEREOF
|
EP2883883A1
(en)
|
2013-12-16 |
2015-06-17 |
Cardio3 Biosciences S.A. |
Therapeutic targets and agents useful in treating ischemia reperfusion injury
|
AU2015217846B2
(en)
|
2014-01-30 |
2019-10-10 |
The Board Of Trustees Of The Leland Stanford Junior University |
Opioid receptor binding agents and uses thereof
|
NL2013661B1
(en)
|
2014-10-21 |
2016-10-05 |
Ablynx Nv |
KV1.3 Binding immunoglobulins.
|
EP3718574A1
(en)
|
2014-07-29 |
2020-10-07 |
Vrije Universiteit Brussel |
Radio-labelled antibody fragments for use in the prevention and/or treatment of cancer
|
US20180036442A1
(en)
|
2014-07-29 |
2018-02-08 |
Vrije Universiteit Brussel |
Radio-labelled antibody fragments for use in the prognosis, diagnosis of cancer as well as for the prediction of cancer therapy response
|
EP3215624B1
(en)
|
2014-11-05 |
2023-11-29 |
Biotalys NV |
Transgenic plant comprising a polynucleotide encoding a variable domain of heavy-chain antibody
|
WO2016097313A1
(en)
|
2014-12-19 |
2016-06-23 |
Ablynx N.V. |
Cysteine linked nanobody dimers
|
JP6917357B2
(en)
|
2015-07-17 |
2021-08-11 |
フレイエ ユニヴェルシテイト ブリュッセルVrije Universiteit Brussel |
Radiolabeled antibody fragment used for cancer treatment
|
SG11201803976VA
(en)
|
2015-11-27 |
2018-06-28 |
Ablynx Nv |
Polypeptides inhibiting cd40l
|
WO2017182605A1
(en)
|
2016-04-22 |
2017-10-26 |
Université Libre de Bruxelles |
A new biomarker expressed in pancreatic beta cells useful in imaging or targeting beta cells
|
US11243214B2
(en)
|
2016-04-22 |
2022-02-08 |
Université Libre de Bruxelles |
Biomarker expressed in pancreatic beta cells useful in imaging or targeting beta cells
|
CN109311968A
(en)
|
2016-05-02 |
2019-02-05 |
埃博灵克斯股份有限公司 |
Treat rsv infection
|
WO2018007442A1
(en)
|
2016-07-06 |
2018-01-11 |
Ablynx N.V. |
Treatment of il-6r related diseases
|
WO2018029182A1
(en)
|
2016-08-08 |
2018-02-15 |
Ablynx N.V. |
Il-6r single variable domain antibodies for treatment of il-6r related diseases
|
US11098113B2
(en)
|
2016-09-15 |
2021-08-24 |
Vib Vzw |
Immunoglobulin single variable domains directed against macrophage migration inhibitory factor
|
WO2018091606A1
(en)
|
2016-11-16 |
2018-05-24 |
Ablynx Nv |
T cell recruiting polypeptides capable of binding cd123 and tcr alpha/beta
|
WO2018099968A1
(en)
|
2016-11-29 |
2018-06-07 |
Ablynx N.V. |
Treatment of infection by respiratory syncytial virus (rsv)
|
EP3589725A1
(en)
|
2017-02-28 |
2020-01-08 |
Vib Vzw |
Means and methods for oral protein delivery
|
CA3058290A1
(en)
|
2017-04-18 |
2018-10-25 |
Universite Libre De Bruxelles |
Biomarkers and targets for proliferative diseases
|
KR20200005635A
(en)
|
2017-05-11 |
2020-01-15 |
브이아이비 브이지더블유 |
Glycosylation of Variable Immunoglobulin Domains
|
EP3630847A1
(en)
|
2017-06-02 |
2020-04-08 |
Merck Patent GmbH |
Adamts binding immunoglobulins
|
BR112019025097A2
(en)
|
2017-06-02 |
2020-07-28 |
Merck Patent Gmbh |
mmp13-binding immunoglobulins
|
JP7249961B2
(en)
|
2017-06-02 |
2023-03-31 |
メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング |
Polypeptides that bind ADAMTS5, MMP13 and aggrecan
|
KR20200013247A
(en)
|
2017-06-02 |
2020-02-06 |
아블린쓰 엔.브이. |
Aggrecan Binding Immunoglobulins
|
WO2019016237A1
(en)
|
2017-07-19 |
2019-01-24 |
Vib Vzw |
Serum albumin binding agents
|
EP3470436A1
(en)
*
|
2017-10-11 |
2019-04-17 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
Anti-igg nanobodies
|
WO2019086548A1
(en)
|
2017-10-31 |
2019-05-09 |
Vib Vzw |
Novel antigen-binding chimeric proteins and methods and uses thereof
|
WO2019155041A1
(en)
|
2018-02-12 |
2019-08-15 |
Vib Vzw |
Gβγ COMPLEX ANTIBODIES AND USES THEREOF
|
CA3092421A1
(en)
|
2018-03-01 |
2019-09-06 |
Vrije Universiteit Brussel |
Human pd-l1-binding immunoglobulins
|
EP4163295A1
(en)
|
2018-03-23 |
2023-04-12 |
Université Libre de Bruxelles |
Wnt signaling agonist molecules
|
MX2020010091A
(en)
|
2018-03-27 |
2021-01-15 |
Umc Utrecht Holding Bv |
Targeted thrombolysis for treatment of microvascular thrombosis.
|
CN108659131B
(en)
*
|
2018-05-28 |
2021-09-14 |
长春力太生物技术有限公司 |
anti-CEACAM-5 single-domain antibody and application thereof
|
CA3138028A1
(en)
|
2019-04-29 |
2020-11-05 |
Confo Therapeutics N.V. |
Chimeric proteins and methods to screen for compounds and ligands binding to gpcrs
|
US20220289837A1
(en)
|
2019-04-30 |
2022-09-15 |
Vib Vzw |
Cystic Fibrosis Transmembrane Conductance Regulator Stabilizing Agents
|
US20220228116A1
(en)
|
2019-05-28 |
2022-07-21 |
Vib Vzw |
Cd8+ t-cells lacking plexins and their application in cancer treatment
|
EP3976650A1
(en)
|
2019-05-28 |
2022-04-06 |
Vib Vzw |
Cancer treatment by targeting plexins in the immune compartment
|
WO2021028837A1
(en)
*
|
2019-08-13 |
2021-02-18 |
Waters Technologies Corporation |
Affinity resins and sample preparation devices based on cartilaginous fish ignar derived binding domains
|
US20220380456A1
(en)
|
2019-10-21 |
2022-12-01 |
Vib Vzw |
Nanodisc-specific antigen-binding chimeric proteins
|
CA3160506A1
(en)
|
2019-11-11 |
2021-05-20 |
Ibi-Ag Innovative Bio Insecticides Ltd. |
Insect control nanobodies and uses thereof
|
EP4065603A1
(en)
|
2019-11-27 |
2022-10-05 |
Vib Vzw |
Positive allosteric modulators of the calcium-sensing receptor
|
GB201918279D0
(en)
|
2019-12-12 |
2020-01-29 |
Vib Vzw |
Glycosylated single chain immunoglobulin domains
|
EP4077372A1
(en)
|
2019-12-20 |
2022-10-26 |
Vib Vzw |
Nanobody exchange chromatography
|
WO2021140205A1
(en)
|
2020-01-10 |
2021-07-15 |
Confo Therapeutics N.V. |
Methods for generating antibodies and antibody fragments and libraries comprising same
|
WO2021156490A2
(en)
|
2020-02-06 |
2021-08-12 |
Vib Vzw |
Corona virus binders
|
WO2021170540A1
(en)
|
2020-02-25 |
2021-09-02 |
Vib Vzw |
Leucine-rich repeat kinase 2 allosteric modulators
|
US20230110053A1
(en)
|
2020-03-31 |
2023-04-13 |
Biotalys NV |
Anti-fungal polypeptides
|
EP4144758A4
(en)
|
2020-04-22 |
2024-05-15 |
Mabwell Shanghai Bioscience Co Ltd |
Single variable domain antibody targeting human programmed death ligand 1 (pd-l1) and derivative thereof
|
WO2021229104A1
(en)
|
2020-05-15 |
2021-11-18 |
Université de Liège |
Anti-cd38 single-domain antibodies in disease monitoring and treatment
|
WO2022003156A1
(en)
|
2020-07-02 |
2022-01-06 |
Oncurious Nv |
Ccr8 non-blocking binders
|
AU2021319024A1
(en)
|
2020-07-31 |
2023-03-23 |
Biotalys NV |
Expression host
|
KR20220026401A
(en)
|
2020-08-25 |
2022-03-04 |
주식회사 에프티넷 |
Aluminum alloy for flux-free brazing and brazing method using the same
|
WO2022063957A1
(en)
|
2020-09-24 |
2022-03-31 |
Vib Vzw |
Biomarker for anti-tumor therapy
|
US20230364049A1
(en)
|
2020-09-24 |
2023-11-16 |
Vib Vzw |
Combination of p2y6 inhibitors and immune checkpoint inhibitors
|
US20220153854A1
(en)
|
2020-09-25 |
2022-05-19 |
Ablynx N.V. |
Polypeptides comprising immunoglobulin single variable domains targeting il-13 and ox40l
|
WO2022117569A1
(en)
|
2020-12-02 |
2022-06-09 |
Oncurious Nv |
A ccr8 antagonist antibody in combination with a lymphotoxin beta receptor agonist antibody in therapy against cancer
|
JP2024508207A
(en)
|
2020-12-02 |
2024-02-26 |
ブイアイビー ブイゼットダブリュ |
LTBR agonists in combination therapy against cancer
|
TW202239763A
(en)
|
2020-12-18 |
2022-10-16 |
比利時商艾伯霖克斯公司 |
Polypeptides comprising immunoglobulin single variable domains targeting il-6 and tnf-α
|
GB202020502D0
(en)
|
2020-12-23 |
2021-02-03 |
Vib Vzw |
Antibody composistion for treatment of corona virus infection
|
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(en)
|
2020-12-24 |
2022-06-30 |
Vib Vzw |
Non-blocking human ccr8 binders
|
EP4267621A1
(en)
|
2020-12-24 |
2023-11-01 |
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Murine cross-reactive human ccr8 binders
|
WO2022136647A1
(en)
|
2020-12-24 |
2022-06-30 |
Oncurious Nv |
Human ccr8 binders
|
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(en)
|
2021-02-05 |
2024-03-29 |
Vib研究所 |
Sha Bei viral binding agents
|
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(en)
|
2021-02-05 |
2023-12-13 |
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Sarbecovirus binders
|
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(en)
|
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2022-08-25 |
Vib Vzw |
Inhibition of slc4a4 in the treatment of cancer
|
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(en)
|
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2023-12-27 |
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Cation-independent mannose-6-phosphate receptor binders
|
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(en)
|
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|
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(en)
|
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|
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(en)
|
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Means and methods for selection of specific binders
|
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(en)
|
2021-06-29 |
2024-02-20 |
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|
AU2022301099A1
(en)
*
|
2021-07-01 |
2024-02-15 |
Ningbo T-Maximum Biopharmaceuticals Co., Ltd. |
Antigen-binding polypeptide targeting b7h3 and application thereof
|
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(en)
|
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2024-03-14 |
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|
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(en)
|
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Cation-independent mannose-6-phosphate receptor binders for targeted protein degradation
|
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(en)
|
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|
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(en)
|
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