AU2002222658A1 - Novel aggrecanase - Google Patents

Novel aggrecanase

Info

Publication number
AU2002222658A1
AU2002222658A1 AU2002222658A AU2265802A AU2002222658A1 AU 2002222658 A1 AU2002222658 A1 AU 2002222658A1 AU 2002222658 A AU2002222658 A AU 2002222658A AU 2265802 A AU2265802 A AU 2265802A AU 2002222658 A1 AU2002222658 A1 AU 2002222658A1
Authority
AU
Australia
Prior art keywords
polypeptide
joint diseases
novel
expression vector
aggrecanase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002222658A
Inventor
Kunitake Abe
Kouichi Nishimura
Noboru Yamaji
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Publication of AU2002222658A1 publication Critical patent/AU2002222658A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)

Abstract

A novel polypeptide, a polynucleotide encoding this polypeptide, an expression vector comprising this polynucleotide, a cell transfected with the expression vector, an antibody binding to the above polypeptide, a convenient screening method for obtaining an agent for treating joint diseases, and a process for manufacturing a pharmaceutical composition for treating joint diseases are disclosed. <??>The polypeptide is a novel aggrecanase causative of joint diseases (particularly an OA disease).
AU2002222658A 2000-12-18 2001-12-17 Novel aggrecanase Abandoned AU2002222658A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000-384300 2000-12-18
JP2000384300 2000-12-18
PCT/JP2001/011033 WO2002050258A1 (en) 2000-12-18 2001-12-17 Novel aggrecanase

Publications (1)

Publication Number Publication Date
AU2002222658A1 true AU2002222658A1 (en) 2002-07-01

Family

ID=18851794

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002222658A Abandoned AU2002222658A1 (en) 2000-12-18 2001-12-17 Novel aggrecanase

Country Status (8)

Country Link
US (2) US7094590B2 (en)
EP (1) EP1344821B9 (en)
JP (1) JP3800175B2 (en)
AT (1) ATE368735T1 (en)
AU (1) AU2002222658A1 (en)
DE (1) DE60129736T2 (en)
ES (1) ES2288909T3 (en)
WO (1) WO2002050258A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6448388B1 (en) * 2000-08-16 2002-09-10 Lexicon Genetics Incorporated Human proteases and polynucleotides encoding the same
ATE368735T1 (en) * 2000-12-18 2007-08-15 Astellas Pharma Inc NEW AGGRECANASE
CA2447935A1 (en) * 2001-06-04 2002-12-12 Curagen Corporation Novel antibodies that bind to antigenic polypeptides, nucleic acids encoding the antigens, and methods of use
WO2003018764A2 (en) * 2001-08-22 2003-03-06 Lexicon Genetics Incorporated Novel human proteases and polynucleotides encoding the same
WO2003027282A1 (en) * 2001-09-24 2003-04-03 Daiichi Fine Chemical Co., Ltd. Adamts-15, -16, -17, -18 and -19
JP2005515779A (en) * 2002-01-31 2005-06-02 ワイス Aggrecanase molecule
AU2003227428A1 (en) * 2002-04-19 2003-11-03 K. K. Dnaform Novel proteins and dnas encoding the same
AU2003282764A1 (en) * 2002-10-07 2004-07-09 Curagen Corporation Therapeutic polypeptides, nucleic acids encoding same, and methods of use
EP1907581A2 (en) * 2005-07-27 2008-04-09 Oncotherapy Science, Inc. Method of diagnosing small cell lung cancer
CA2641372A1 (en) * 2006-02-08 2007-08-30 Usv Limited Affinity polypeptide for purification of recombinant proteins
BRPI0920582A2 (en) 2008-10-16 2019-08-27 Cytonics Corp biomarkers and methods for detecting and treating spinal and joint pain

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6451575B1 (en) 1997-07-25 2002-09-17 Bristol-Myers Squibb Pharma Company Aggrecan degrading metallo proteases
US6927056B2 (en) * 2001-09-06 2005-08-09 Incyte Corporation Proteases
ATE368735T1 (en) * 2000-12-18 2007-08-15 Astellas Pharma Inc NEW AGGRECANASE
US20040018555A1 (en) * 2001-06-04 2004-01-29 Anderson David W. Novel antibodies that bind to antigenic polypeptides, nucleic acids encoding the antigens, and methods of use
WO2003027282A1 (en) * 2001-09-24 2003-04-03 Daiichi Fine Chemical Co., Ltd. Adamts-15, -16, -17, -18 and -19
JP2003144154A (en) * 2001-11-14 2003-05-20 Mitsubishi Pharma Corp New adamts family polypeptide and gene encoding the same

Also Published As

Publication number Publication date
EP1344821B1 (en) 2007-08-01
DE60129736D1 (en) 2007-09-13
US20030185828A1 (en) 2003-10-02
WO2002050258A1 (en) 2002-06-27
DE60129736T2 (en) 2008-04-17
JP3800175B2 (en) 2006-07-26
ATE368735T1 (en) 2007-08-15
US7193073B2 (en) 2007-03-20
EP1344821B9 (en) 2008-02-27
EP1344821A1 (en) 2003-09-17
US20060078957A1 (en) 2006-04-13
JPWO2002050258A1 (en) 2004-04-22
US7094590B2 (en) 2006-08-22
EP1344821A4 (en) 2004-06-09
ES2288909T3 (en) 2008-02-01

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