AU2002218436A1 - Crystal forms of 6-((4-chloro-phenyl) -hydroxy-(-3-methyl- 3h-imidaol-4-yl) -methyl) -4-(3-ethynyl-phenyl) -1-methyl-1h- quinolin-2-one, 2,3- dihydroxybutanedioate salts and method of production - Google Patents

Crystal forms of 6-((4-chloro-phenyl) -hydroxy-(-3-methyl- 3h-imidaol-4-yl) -methyl) -4-(3-ethynyl-phenyl) -1-methyl-1h- quinolin-2-one, 2,3- dihydroxybutanedioate salts and method of production

Info

Publication number
AU2002218436A1
AU2002218436A1 AU2002218436A AU1843602A AU2002218436A1 AU 2002218436 A1 AU2002218436 A1 AU 2002218436A1 AU 2002218436 A AU2002218436 A AU 2002218436A AU 1843602 A AU1843602 A AU 1843602A AU 2002218436 A1 AU2002218436 A1 AU 2002218436A1
Authority
AU
Australia
Prior art keywords
methyl
phenyl
imidaol
dihydroxybutanedioate
quinolin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002218436A
Other languages
English (en)
Inventor
Zheng Jane Li
Joseph Peter Lyssikatos
Clifford Nathaniel Meltz
Linda Sue Newton
Drek Lawrence Tickner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Products Inc
Original Assignee
Pfizer Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc filed Critical Pfizer Products Inc
Publication of AU2002218436A1 publication Critical patent/AU2002218436A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
AU2002218436A 2000-12-19 2001-12-03 Crystal forms of 6-((4-chloro-phenyl) -hydroxy-(-3-methyl- 3h-imidaol-4-yl) -methyl) -4-(3-ethynyl-phenyl) -1-methyl-1h- quinolin-2-one, 2,3- dihydroxybutanedioate salts and method of production Abandoned AU2002218436A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25659800P 2000-12-19 2000-12-19
US60/256,598 2000-12-19
PCT/IB2001/002299 WO2002050058A1 (fr) 2000-12-19 2001-12-03 Formes cristallines de sels de 6-[(4-chloro-phenyl)-hydroxy-(3-methyl-3h-imidazol-4-yl)-methyl]-4-(3-ethynyl-phenyl)-1-methyl-1h-quinoleine-2-one, 2,3-dihydroxybutanedioate et procede de preparation

Publications (1)

Publication Number Publication Date
AU2002218436A1 true AU2002218436A1 (en) 2002-07-01

Family

ID=22972839

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002218436A Abandoned AU2002218436A1 (en) 2000-12-19 2001-12-03 Crystal forms of 6-((4-chloro-phenyl) -hydroxy-(-3-methyl- 3h-imidaol-4-yl) -methyl) -4-(3-ethynyl-phenyl) -1-methyl-1h- quinolin-2-one, 2,3- dihydroxybutanedioate salts and method of production

Country Status (8)

Country Link
US (3) US6645982B2 (fr)
EP (1) EP1395577A1 (fr)
JP (1) JP2004516287A (fr)
AU (1) AU2002218436A1 (fr)
BR (1) BR0116302A (fr)
CA (2) CA2632091C (fr)
MX (1) MXPA03005525A (fr)
WO (1) WO2002050058A1 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070293539A1 (en) * 2004-03-18 2007-12-20 Lansbury Peter T Methods for the treatment of synucleinopathies
WO2005089515A2 (fr) * 2004-03-18 2005-09-29 The Brigham And Women's Hospital, Inc. Procedes de traitement des synucleinopathies
CA2559282A1 (fr) * 2004-03-18 2005-09-29 Brigham And Women's Hospital, Inc. Procedes pour le traitement de synucleinopathies
CA2559285A1 (fr) * 2004-03-18 2005-09-29 Brigham And Women's Hospital, Inc. Traitement des synucleinopathies
JP2007538004A (ja) * 2004-03-18 2007-12-27 ザ ブライハム アンド ウイメンズ ホスピタル， インコーポレイテッド シヌクレイノパチーを治療する方法
US8025227B2 (en) * 2005-09-30 2011-09-27 Rockwell Automation Technologies, Inc. Access to distributed databases via pointer stored in RFID tag
WO2007056317A2 (fr) * 2005-11-07 2007-05-18 Novartis Vaccines & Diagnostics, Inc. Procedes destines a analyser un ingredient pharmaceutique
EP1968591A4 (fr) * 2005-12-23 2010-02-17 Link Medicine Corp Traitement de formes de synucleinopathie
EP2155197A4 (fr) * 2007-03-09 2011-10-12 Link Medicine Corp Traitement des maladies de surcharge lysosomale
US8232402B2 (en) 2008-03-12 2012-07-31 Link Medicine Corporation Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications
US20100331363A1 (en) * 2008-11-13 2010-12-30 Link Medicine Corporation Treatment of mitochondrial disorders using a farnesyl transferase inhibitor
US20110060005A1 (en) * 2008-11-13 2011-03-10 Link Medicine Corporation Treatment of mitochondrial disorders using a farnesyl transferase inhibitor
BRPI0920927A2 (pt) 2008-11-13 2019-09-24 Link Medicine Corp derivados de azaquinolinona e usos dos mesmos
EP3579872A1 (fr) 2017-02-10 2019-12-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés et compositions pharmaceutiques pour le traitement de cancers associés à l'activation de la voie mapk

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2135312C (fr) 1992-05-13 2006-09-26 Charles Myers Utilisation d'inhibiteurs de la 3-hydroxy-3-methylglutaryl coenzyme a-reductase comme methode de traitement du cancer
US5747498A (en) 1996-05-28 1998-05-05 Pfizer Inc. Alkynyl and azido-substituted 4-anilinoquinazolines
ATE302613T1 (de) 1995-08-09 2005-09-15 Banyu Pharma Co Ltd Proteinfarnesyltransferase-inhibitoren in kombination mit hmgcoa-reduktase-inhibitoren zur behandlung von aids
TW349948B (en) 1995-10-31 1999-01-11 Janssen Pharmaceutica Nv Farnesyl transferase inhibiting 2-quinolone derivatives
SI1162201T1 (sl) 1995-12-08 2006-08-31 Janssen Pharmaceutica Nv (Imidazol-5-il)metil-2-kinolinonski derivati kot inhibitorji farnezil protein transferaze
JPH11512750A (ja) 1996-06-27 1999-11-02 ファイザー インク． ２―（２―オキソ―エチリデン）―イミダゾリジン―４―オンの誘導体およびファルネシル蛋白質トランスフェラーゼ阻害物質としてのそれらの使用法
UA57081C2 (uk) 1997-06-16 2003-06-16 Пфайзер Продактс Інк. Фармацевтична композиція для лікування раку або доброякісних проліферативних хвороб у ссавців, спосіб лікування, фармацевтична композиція для інгібування ненормального росту клітин у ссавців та спосіб інгібування
JP3495706B2 (ja) 1998-08-27 2004-02-09 ファイザー・プロダクツ・インク 抗癌薬として有用なアルキニル置換キノリン−２−オン誘導体
WO2000016778A1 (fr) 1998-09-24 2000-03-30 Merck & Co., Inc. Procede de traitement du cancer

Also Published As

Publication number Publication date
CA2632091C (fr) 2011-03-22
CA2432137C (fr) 2010-12-21
CA2432137A1 (fr) 2002-06-27
BR0116302A (pt) 2004-01-13
JP2004516287A (ja) 2004-06-03
CA2632091A1 (fr) 2002-06-27
US6734308B2 (en) 2004-05-11
US20050020836A1 (en) 2005-01-27
MXPA03005525A (es) 2003-10-06
US6645982B2 (en) 2003-11-11
WO2002050058A1 (fr) 2002-06-27
WO2002050058A8 (fr) 2003-02-20
US20030212103A1 (en) 2003-11-13
US20030032653A1 (en) 2003-02-13
EP1395577A1 (fr) 2004-03-10

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