AU2002214056A1 - Farnesyl transferase inhibiting benzoheterocyclic derivatives - Google Patents
Farnesyl transferase inhibiting benzoheterocyclic derivativesInfo
- Publication number
- AU2002214056A1 AU2002214056A1 AU2002214056A AU1405602A AU2002214056A1 AU 2002214056 A1 AU2002214056 A1 AU 2002214056A1 AU 2002214056 A AU2002214056 A AU 2002214056A AU 1405602 A AU1405602 A AU 1405602A AU 2002214056 A1 AU2002214056 A1 AU 2002214056A1
- Authority
- AU
- Australia
- Prior art keywords
- sup
- farnesyl transferase
- transferase inhibiting
- benzoheterocyclic derivatives
- benzoheterocyclic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 102000007317 Farnesyltranstransferase Human genes 0.000 title abstract 2
- 108010007508 Farnesyltranstransferase Proteins 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
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- A61P11/16—Central respiratory analeptics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Abstract
This invention comprises the novel compounds of formula (I) wherein r, s, t, X, Z, R<SUP>1</SUP>, R<SUP>2</SUP>, R<SUP>3</SUP>, R<SUP>4</SUP>, R<SUP>5</SUP>, R<SUP>6 </SUP>and R<SUP>7 </SUP>have defined meanings, having farnesyl transferase inhibiting activity; their preparation, compositions containing them and their use as a medicine.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00204149 | 2000-11-21 | ||
EP00204149 | 2000-11-21 | ||
PCT/EP2001/013317 WO2002042296A1 (en) | 2000-11-21 | 2001-11-15 | Farnesyl transferase inhibiting benzoheterocyclic derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2002214056A1 true AU2002214056A1 (en) | 2002-06-03 |
Family
ID=8172314
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2002214056A Abandoned AU2002214056A1 (en) | 2000-11-21 | 2001-11-15 | Farnesyl transferase inhibiting benzoheterocyclic derivatives |
Country Status (8)
Country | Link |
---|---|
US (1) | US7153958B2 (en) |
EP (1) | EP1339709B1 (en) |
JP (1) | JP4348080B2 (en) |
AT (1) | ATE434615T1 (en) |
AU (1) | AU2002214056A1 (en) |
DE (1) | DE60139080D1 (en) |
ES (1) | ES2328225T3 (en) |
WO (1) | WO2002042296A1 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005111217A2 (en) | 2004-04-29 | 2005-11-24 | U.S. Smokeless Tobacco Company | Nicotiana nucleic acid molecules and uses thereof |
US8232402B2 (en) | 2008-03-12 | 2012-07-31 | Link Medicine Corporation | Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications |
BRPI0920927A2 (en) | 2008-11-13 | 2019-09-24 | Link Medicine Corp | azaquinolinone derivatives and uses thereof |
CN113072509B (en) * | 2021-03-01 | 2022-11-25 | 中国科学院成都有机化学有限公司 | Method for synthesizing 7-amino clonazepam compound |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3682892A (en) * | 1970-12-23 | 1972-08-08 | Hoffmann La Roche | 7-hydroxy lower alkyl benzodiazepines |
IL42416A (en) | 1972-07-13 | 1976-06-30 | Sparamedica Ag | 6-phenyl-4h-s-triazolo(4,3-alpha)(1,4)benzodiazepine and n-oxide derivatives,their preparation and pharmaceutical compositions containing them |
DE3610848A1 (en) * | 1986-04-01 | 1987-10-15 | Boehringer Ingelheim Kg | NEW 1,4-DIAZEPINE |
JP2742053B2 (en) | 1986-07-31 | 1998-04-22 | オーエン ハント,アンソニー | Flexible coupling |
CA2002864C (en) * | 1988-11-29 | 1999-11-16 | Eddy J. E. Freyne | (1h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives |
MX9704683A (en) | 1994-12-23 | 1997-09-30 | Pfizer | Naphthyl-benzoxazepines or -benzothiazepines as squalene synthetase inhibitors. |
TW316902B (en) * | 1994-12-28 | 1997-10-01 | Janssen Pharmaceutica Nv | |
TW349948B (en) | 1995-10-31 | 1999-01-11 | Janssen Pharmaceutica Nv | Farnesyl transferase inhibiting 2-quinolone derivatives |
PT1162201E (en) * | 1995-12-08 | 2006-08-31 | Janssen Pharmaceutica Nv | (IMIDAZOL-5-IL) METHYL-2-KINOLINONE DERIVATIVES AS FARNESIL PROTEIN INHIBITORS TRANSFERASE |
US6011029A (en) * | 1996-02-26 | 2000-01-04 | Bristol-Myers Squibb Company | Inhibitors of farnesyl protein transferase |
TW591030B (en) | 1997-03-10 | 2004-06-11 | Janssen Pharmaceutica Nv | Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles |
ES2289783T3 (en) | 1997-04-25 | 2008-02-01 | Janssen Pharmaceutica N.V. | QUINAZOLINONAS THAT INHIBIT THE FARNESILTRANSFERASA. |
DK0988038T3 (en) | 1997-06-02 | 2002-12-02 | Janssen Pharmaceutica Nv | Use of (imidazol-5-yl) methyl-2-quinolinone derivatives to inhibit smooth muscle cell proliferation |
CZ300968B6 (en) | 1998-07-06 | 2009-09-30 | Janssen Pharmaceutica N. V. | Pharmaceutical composition having radiosensitive properties and comprising farnesyl-protein transferase inhibitor |
TR200003882T2 (en) | 1998-07-06 | 2001-06-21 | Janssen Pharmaceutica N.V. | Farnesyl protein transferase inhibitors for the treatment of arthropathies. |
AP2001002079A0 (en) | 1998-08-27 | 2001-03-31 | Pfizer Prod Inc | Alkynyl-substituted quinolin-2-one derivatives useful as anticancer agents. |
JP3494409B2 (en) | 1998-08-27 | 2004-02-09 | ファイザー・プロダクツ・インク | Alkynyl-substituted quinolin-2-one derivatives useful as anticancer agents |
ATE240327T1 (en) * | 1998-12-23 | 2003-05-15 | Janssen Pharmaceutica Nv | 1,2-ANNELATED QUINOLINE DERIVATIVES |
WO2000047574A1 (en) | 1999-02-11 | 2000-08-17 | Pfizer Products Inc. | Heteroaryl-substituted quinolin-2-one derivatives useful as anticancer agents |
HN2000000266A (en) | 2000-01-21 | 2001-05-21 | Pfizer Prod Inc | ANTI-TARGET COMPOUND AND METHOD OF SEPARATION OF ENANTIOMERS USEFUL TO SYNTHEIZE SUCH COMPOUND. |
-
2001
- 2001-11-15 EP EP01982492A patent/EP1339709B1/en not_active Expired - Lifetime
- 2001-11-15 AU AU2002214056A patent/AU2002214056A1/en not_active Abandoned
- 2001-11-15 AT AT01982492T patent/ATE434615T1/en not_active IP Right Cessation
- 2001-11-15 US US10/432,292 patent/US7153958B2/en not_active Expired - Lifetime
- 2001-11-15 WO PCT/EP2001/013317 patent/WO2002042296A1/en active Application Filing
- 2001-11-15 ES ES01982492T patent/ES2328225T3/en not_active Expired - Lifetime
- 2001-11-15 JP JP2002544430A patent/JP4348080B2/en not_active Expired - Fee Related
- 2001-11-15 DE DE60139080T patent/DE60139080D1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1339709A1 (en) | 2003-09-03 |
US7153958B2 (en) | 2006-12-26 |
ES2328225T3 (en) | 2009-11-11 |
US20040034218A1 (en) | 2004-02-19 |
JP4348080B2 (en) | 2009-10-21 |
WO2002042296A1 (en) | 2002-05-30 |
EP1339709B1 (en) | 2009-06-24 |
DE60139080D1 (en) | 2009-08-06 |
JP2004514677A (en) | 2004-05-20 |
ATE434615T1 (en) | 2009-07-15 |
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