AU2002211517A1 - Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits - Google Patents
Magnetic resonance imaging agents for in vivo labeling and detection of amyloid depositsInfo
- Publication number
- AU2002211517A1 AU2002211517A1 AU2002211517A AU1151702A AU2002211517A1 AU 2002211517 A1 AU2002211517 A1 AU 2002211517A1 AU 2002211517 A AU2002211517 A AU 2002211517A AU 1151702 A AU1151702 A AU 1151702A AU 2002211517 A1 AU2002211517 A1 AU 2002211517A1
- Authority
- AU
- Australia
- Prior art keywords
- detection
- magnetic resonance
- resonance imaging
- imaging agents
- amyloid deposits
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/12—Macromolecular compounds
- A61K49/122—Macromolecular compounds dimers of complexes or complex-forming compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
- A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
- A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
- A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
- A61K49/1833—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with a small organic molecule
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Nanotechnology (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Radiology & Medical Imaging (AREA)
- Medicinal Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Medical Informatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23823100P | 2000-10-04 | 2000-10-04 | |
US60/238,231 | 2000-10-04 | ||
US28537901P | 2001-04-20 | 2001-04-20 | |
US60/285,379 | 2001-04-20 | ||
PCT/US2001/031415 WO2002028441A2 (en) | 2000-10-04 | 2001-10-04 | Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2002211517A1 true AU2002211517A1 (en) | 2002-04-15 |
Family
ID=26931450
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2002211517A Abandoned AU2002211517A1 (en) | 2000-10-04 | 2001-10-04 | Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits |
Country Status (3)
Country | Link |
---|---|
US (1) | US7029655B2 (en) |
AU (1) | AU2002211517A1 (en) |
WO (1) | WO2002028441A2 (en) |
Families Citing this family (39)
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US6770261B2 (en) * | 1995-06-02 | 2004-08-03 | Research Corporation Technologies | Magnetic resonance imaging agents for the detection of physiological agents |
AU752812B2 (en) | 1997-11-17 | 2002-10-03 | Research Corporation Technologies, Inc. | Magnetic resonance imaging agents for the detection of physiological agents |
US20040146463A1 (en) * | 2000-05-04 | 2004-07-29 | Meade Thomas J. | Functional MRI agents for cancer imaging |
WO2002016951A2 (en) | 2000-08-21 | 2002-02-28 | The General Hospital Corporation | Methods for diagnosing a neurodegenerative condition |
US20030004236A1 (en) * | 2001-04-20 | 2003-01-02 | Meade Thomas J. | Magnetic resonance imaging agents for detection and delivery of therapeutic agents and detection of physiological substances |
EP2298361A3 (en) * | 2001-04-27 | 2011-05-04 | The General Hospital Corporation | Ocular diagnosis of Alzheimer's disease |
US20020197648A1 (en) * | 2001-05-02 | 2002-12-26 | Silva Robin M. | High throughput screening methods using magnetic resonance imaging agents |
US20030198597A1 (en) * | 2002-04-22 | 2003-10-23 | Meade Thomas J. | Novel macrocyclic activatible magnetic resonance imaging contrast agents |
EP1380290A1 (en) * | 2002-07-09 | 2004-01-14 | Universitair Medisch Centrum Utrecht | Cross-beta structure pathway and its therapeutic relevance |
AU2004206956A1 (en) * | 2003-01-22 | 2004-08-05 | The General Hospital Corporation | Amyloid-binding, metal-chelating agents |
JP3877754B2 (en) * | 2003-10-30 | 2007-02-07 | 株式会社同仁化学研究所 | Amyloid affinity compounds |
US8986650B2 (en) | 2005-10-07 | 2015-03-24 | Guerbet | Complex folate-NOTA-Ga68 |
CA2625196C (en) | 2005-10-07 | 2016-04-05 | Guerbet | Compounds comprising a biological target recognizing part, coupled to a signal part capable of complexing gallium |
US20070258907A1 (en) * | 2006-04-24 | 2007-11-08 | Davis Mark E | Polymer-coated paramagnetic particles |
US8337813B2 (en) * | 2007-09-14 | 2012-12-25 | Northwestern University | Contrast agents |
KR100987592B1 (en) | 2008-03-10 | 2010-10-12 | 경북대학교 산학협력단 | MR Contrast Medium And Method For Preparing The Same |
WO2009120995A2 (en) | 2008-03-27 | 2009-10-01 | Purdue Research Foundation | Collagen-binding synthetic peptidoglycans, preparation, and methods of use |
US8580231B2 (en) | 2008-05-23 | 2013-11-12 | Northwestern University | Compositions and methods comprising magnetic resonance contrast agents |
US20100029909A1 (en) * | 2008-05-23 | 2010-02-04 | Northwestern University | Compositions and methods comprising magnetic resonance contrast agents |
US20100129290A1 (en) * | 2008-11-26 | 2010-05-27 | I.S.T. Corporation | Smart contrast agent and detection method for detecting transition metal ions |
FR2942227B1 (en) | 2009-02-13 | 2011-04-15 | Guerbet Sa | USE OF BUFFERS FOR RADIONUCLEID COMPLEXATION |
WO2012003554A2 (en) * | 2010-07-08 | 2012-01-12 | Katholieke Universiteit Leuven | Compositions and methods for removal or destruction of amyloid fibril or amyloid adhesin comprising aggregates |
WO2012078647A2 (en) * | 2010-12-07 | 2012-06-14 | Steven Verdooner | Chemical composition to detect and treat amyloid in a patient's brain and retina |
FR2968999B1 (en) | 2010-12-20 | 2013-01-04 | Guerbet Sa | CHELATE NANOEMULSION FOR MRI |
JP6212032B2 (en) * | 2011-04-06 | 2017-10-18 | ボード・オブ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・テキサス・システム | Lipid-based nanoparticles |
JP6038122B2 (en) | 2011-04-21 | 2016-12-07 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | Functional magnetic nanoparticles and their use in image processing of amyloid deposits and neurofibrillary tangles |
ES2708076T3 (en) | 2011-05-24 | 2019-04-08 | Symic Ip Llc | Synthetic peptidoglycans that bind to hyaluronic acid, preparation and methods of use |
FR2980364B1 (en) | 2011-09-26 | 2018-08-31 | Guerbet | NANOEMULSIONS AND THEIR USE AS CONTRAST AGENTS |
NL2007714C2 (en) | 2011-11-04 | 2013-05-08 | Academisch Ziekenhuis Leiden Lumc | Imaging ligands. |
CN104081416B (en) | 2012-01-20 | 2018-10-02 | A·安那普拉加达 | Method and composition for objectively characterizing medical image |
FR3001154B1 (en) | 2013-01-23 | 2015-06-26 | Guerbet Sa | MAGNETO-EMULSION VECTORIZED |
WO2014124334A2 (en) | 2013-02-08 | 2014-08-14 | Misfolding Diagnostics, Inc. | Transthyretin antibodies and uses thereof |
JP6603650B2 (en) | 2013-03-15 | 2019-11-06 | パーデュー・リサーチ・ファウンデーション | Extracellular matrix-bound synthetic peptidoglycan |
US10772931B2 (en) | 2014-04-25 | 2020-09-15 | Purdue Research Foundation | Collagen binding synthetic peptidoglycans for treatment of endothelial dysfunction |
CA2963941C (en) | 2014-10-08 | 2023-08-01 | Texas Children's Hosptial | Mri imaging of amyloid plaque using liposomes |
US9737698B2 (en) * | 2016-01-04 | 2017-08-22 | Givi Topchiashvili | Method and system for treating patients with alzheimer disease |
KR20200026263A (en) | 2017-07-07 | 2020-03-10 | 시믹 아이피, 엘엘씨 | Synthetic bioconjugates |
WO2020007822A1 (en) | 2018-07-02 | 2020-01-09 | Conservatoire National Des Arts Et Metiers (Cnam) | Bismuth metallic (0) nanoparticles, process of manufacturing and uses thereof |
CN112735799B (en) * | 2020-12-10 | 2022-12-20 | 华东理工大学 | Novel magnetic material and preparation method thereof |
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US4837169A (en) | 1981-07-01 | 1989-06-06 | Eastman Kodak Company | Polypyridine Fluorescent labels for immunoassay |
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US5188816A (en) | 1984-10-18 | 1993-02-23 | Board Of Regents, The University Of Texas System | Using polyazamacrocyclic compounds for intracellular measurement of metal ions using MRS |
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US4877872A (en) | 1986-06-24 | 1989-10-31 | The University Of Toledo | Production and use of dimers of hematoporophyrin, purpurins, chlorines and purpurin- and chlorin-complexes |
US5219553A (en) | 1986-08-04 | 1993-06-15 | Salutar, Inc. | Composition of a n-carboxymethylated tetraazacyclododecane chelating agent, a paramagnetic metal and excess calcium ions for MRI |
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-
2001
- 2001-10-04 US US09/972,302 patent/US7029655B2/en not_active Expired - Fee Related
- 2001-10-04 WO PCT/US2001/031415 patent/WO2002028441A2/en active Application Filing
- 2001-10-04 AU AU2002211517A patent/AU2002211517A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2002028441A9 (en) | 2003-02-20 |
WO2002028441A3 (en) | 2002-06-13 |
US20020098153A1 (en) | 2002-07-25 |
US7029655B2 (en) | 2006-04-18 |
WO2002028441A2 (en) | 2002-04-11 |
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