AU2001295837A1 - Aminoalkylpyrrolidine serotonin receptor ligands and compositions, their pharmaceutical uses, and methods for their synthesis - Google Patents

Aminoalkylpyrrolidine serotonin receptor ligands and compositions, their pharmaceutical uses, and methods for their synthesis

Info

Publication number
AU2001295837A1
AU2001295837A1 AU2001295837A AU9583701A AU2001295837A1 AU 2001295837 A1 AU2001295837 A1 AU 2001295837A1 AU 2001295837 A AU2001295837 A AU 2001295837A AU 9583701 A AU9583701 A AU 9583701A AU 2001295837 A1 AU2001295837 A1 AU 2001295837A1
Authority
AU
Australia
Prior art keywords
receptor ligands
methods
aminoalkylpyrrolidine
compositions
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001295837A
Inventor
Yufeng Hong
Atsuo Kuki
David Robert Luthin
Zhengwei Peng
Yuanjin Rui
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of AU2001295837A1 publication Critical patent/AU2001295837A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Novel aminoalkylpyrrolidine 5-HT<SUB>7 </SUB>receptor ligands, methods of preparing such ligands, intermediate compounds useful in the preparation of the receptor ligands, pharmaceutical compositions comprising the receptor ligands, and methods of treating sleep disorders, pain, depression, and schizophrenia employing the receptor ligands are disclosed. The receptor ligands have formula (1): wherein the formula variables are as defined herein, and pharmaceutically acceptable salts, solvates, active metabolites or prodrugs thereof.
AU2001295837A 2000-10-30 2001-10-26 Aminoalkylpyrrolidine serotonin receptor ligands and compositions, their pharmaceutical uses, and methods for their synthesis Abandoned AU2001295837A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24371000P 2000-10-30 2000-10-30
US60243710 2000-10-30
PCT/IB2001/002023 WO2002036560A1 (en) 2000-10-30 2001-10-26 Aminoalkylpyrrolidine serotonin receptor ligands and compositions, their pharmaceutical uses, and methods for their synthesis

Publications (1)

Publication Number Publication Date
AU2001295837A1 true AU2001295837A1 (en) 2002-05-15

Family

ID=22919809

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001295837A Abandoned AU2001295837A1 (en) 2000-10-30 2001-10-26 Aminoalkylpyrrolidine serotonin receptor ligands and compositions, their pharmaceutical uses, and methods for their synthesis

Country Status (11)

Country Link
US (2) US20040039044A1 (en)
EP (1) EP1339677B1 (en)
JP (1) JP2004517058A (en)
AT (1) ATE315023T1 (en)
AU (1) AU2001295837A1 (en)
BR (1) BR0115042A (en)
CA (1) CA2425286A1 (en)
DE (1) DE60116517T2 (en)
ES (1) ES2251514T3 (en)
MX (1) MXPA03002595A (en)
WO (1) WO2002036560A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1300108C (en) * 2004-12-29 2007-02-14 浙江大学 Method for synthesizing 1-methyl-2-amine ethyl pyrrolidine
EP1875899A1 (en) * 2006-06-29 2008-01-09 Laboratorios Del Dr. Esteve, S.A. Use of 5HT7 receptor agonists for the treatment of pain
EP2521714B1 (en) * 2010-01-05 2015-08-12 Suven Life Sciences Limited Aromatic sulfone compounds useful in the treatment of central nervous disorders
AR080375A1 (en) * 2010-03-05 2012-04-04 Sanofi Aventis PROCEDURE FOR THE PREPARATION OF 2- (CYCLOHEXIMETHYL) -N- {2 - [(2S) -1-METHYLPIRROLIDIN-2-IL] ETIL} -1,2,3,4-TETRAHYDROISOCHINOLINE- 7-SULFONAMIDE
MX2021016005A (en) * 2019-06-26 2022-06-16 Enyo Pharma Tertiary amine derivatives and their uses for treating a viral infection.
CN111960983A (en) * 2020-08-31 2020-11-20 南通大学 N-methyl-3- (1-methylpyrrolidine-3-yl) propyl-1-amine and synthetic method thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1584800A (en) * 1968-09-09 1970-01-02
IL36728A0 (en) * 1970-05-14 1971-06-23 Richardson Merrell Inc Substituted pyrrolylmethylamines and their preparation
FR2319337A1 (en) * 1975-07-30 1977-02-25 Fabre Sa Pierre GEM DIARYLES WITH ANTIARRHYTHMIC ACTIVITY USEFUL IN CARDIOVASCULAR THERAPEUTICS
DE3835291A1 (en) * 1988-04-19 1989-11-02 Bayer Ag 1,3-DISUBSTITUTED PYRROLIDINES
US5571832A (en) * 1992-11-13 1996-11-05 The United States Of America As Represented By The Department Of Health And Human Services Nitrogen-containing cyclohetero alkylamino aryl derivatives for CNS disorders
AU2960599A (en) * 1998-03-30 1999-10-18 Akira Karasawa Quinazoline derivatives
US6699873B1 (en) * 1999-08-04 2004-03-02 Millennium Pharmaceuticals, Inc. Melanocortin-4 receptor binding compounds and methods of use thereof
AU6621600A (en) * 1999-08-04 2001-03-05 Millennium Pharmaceuticals, Inc. Melanocortin-4 receptor binding compounds and methods of use thereof
AU2868601A (en) * 2000-01-27 2001-08-07 Ribotargets Ltd Biaryl compounds, their preparation and their use in therapy

Also Published As

Publication number Publication date
WO2002036560A1 (en) 2002-05-10
BR0115042A (en) 2004-02-03
DE60116517T2 (en) 2006-08-17
EP1339677A1 (en) 2003-09-03
US20060063932A1 (en) 2006-03-23
CA2425286A1 (en) 2002-05-10
ATE315023T1 (en) 2006-02-15
US20040039044A1 (en) 2004-02-26
DE60116517D1 (en) 2006-03-30
JP2004517058A (en) 2004-06-10
EP1339677B1 (en) 2006-01-04
MXPA03002595A (en) 2003-06-30
ES2251514T3 (en) 2006-05-01

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