AU2001284113A1 - Novel diamines having a casr modulating activity - Google Patents

Novel diamines having a casr modulating activity

Info

Publication number
AU2001284113A1
AU2001284113A1 AU2001284113A AU8411301A AU2001284113A1 AU 2001284113 A1 AU2001284113 A1 AU 2001284113A1 AU 2001284113 A AU2001284113 A AU 2001284113A AU 8411301 A AU8411301 A AU 8411301A AU 2001284113 A1 AU2001284113 A1 AU 2001284113A1
Authority
AU
Australia
Prior art keywords
casr
modulating activity
novel diamines
diamines
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001284113A
Inventor
Philippe Marcel Dauban
Robert Hugh Dodd
Helene Veronique Faure
Pierre Jean-Paul Potier
Martial Ruat
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Original Assignee
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS filed Critical Centre National de la Recherche Scientifique CNRS
Publication of AU2001284113A1 publication Critical patent/AU2001284113A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/34Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
    • C07C211/36Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing at least two amino groups bound to the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/20Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D203/00Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/26Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2001284113A 2000-08-08 2001-08-07 Novel diamines having a casr modulating activity Abandoned AU2001284113A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0010427 2000-08-08
FR0010427A FR2812875B1 (en) 2000-08-08 2000-08-08 NOVEL DIAMINES HAVING CASR MODULATING ACTIVITY AND THEIR METHOD OF PREPARATION
PCT/FR2001/002562 WO2002012181A1 (en) 2000-08-08 2001-08-07 Novel diamines having a casr modulating activity

Publications (1)

Publication Number Publication Date
AU2001284113A1 true AU2001284113A1 (en) 2002-02-18

Family

ID=8853394

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001284113A Abandoned AU2001284113A1 (en) 2000-08-08 2001-08-07 Novel diamines having a casr modulating activity

Country Status (6)

Country Link
US (1) US7157498B2 (en)
EP (1) EP1409453A1 (en)
JP (1) JP4896350B2 (en)
AU (1) AU2001284113A1 (en)
FR (1) FR2812875B1 (en)
WO (1) WO2002012181A1 (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1757582B1 (en) 2004-05-28 2015-12-30 Mitsubishi Tanabe Pharma Corporation Arylalkylamines and process for production thereof
US7361789B1 (en) 2004-07-28 2008-04-22 Amgen Inc. Dihydronaphthalene compounds, compositions, uses thereof, and methods for synthesis
FR2885129B1 (en) * 2005-04-29 2007-06-15 Proskelia Sas NOVEL DERIVATIVES OF UREEE SUBSTITUTED WITH THIAZOLE OR BENZOTHIAZOLE, PROCESS FOR THE PREPARATION THEREOF, THEIR USE AS MEDICAMENTS, THE PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND THE USE THEREOF
US7875609B2 (en) * 2005-11-25 2011-01-25 Galapagos Sasu Urea derivatives, processes for their preparation, their use as medicaments, and pharmaceutical compositions containing them
CA2648939C (en) * 2006-04-20 2014-07-08 Amgen Inc. Stable emulsion formulations
CA2672956C (en) * 2006-10-26 2015-02-10 Amgen Inc. Calcium receptor modulating agents
AU2008233088B2 (en) 2007-03-30 2013-09-26 Amgen Inc. Calcimimetic compounds for use in the treatment of bowel disorders
ES2476391T3 (en) * 2007-10-15 2014-07-14 Amgen Inc. Calcium receptor modulating agents
WO2010042642A1 (en) * 2008-10-08 2010-04-15 Amgen Inc. Calcium receptor modulating agents
WO2010104882A1 (en) 2009-03-10 2010-09-16 Amgen Inc. Methods of modulating sperm motility
US8765676B2 (en) 2009-05-27 2014-07-01 Leo Pharma A/S Calcium sensing receptor modulating compounds and pharmaceutical use thereof
EP2435400A2 (en) 2009-05-27 2012-04-04 Leo Pharma A/S Novel calcium sensing receptor modulating compounds and pharmaceutical use thereof
CN102958907A (en) 2010-06-30 2013-03-06 利奥制药有限公司 New polymorphic form of calcimimetic compound
JP5968881B2 (en) 2010-06-30 2016-08-10 レオ ファーマ アクティーゼルスカブ New polymorphs of calcium mimetic compounds
WO2012069421A1 (en) 2010-11-26 2012-05-31 Leo Pharma A/S Calcium-sensing receptor-active compounds
JP2014500882A (en) 2010-11-26 2014-01-16 レオ ファーマ アクティーゼルスカブ Calcium-sensing receptor active compound
RU2013128981A (en) 2010-11-26 2015-01-10 Лео Фарма А/С COMPOUNDS ACTIVE AGAINST CALCIUM SENSITIVE RECEPTORS
WO2012069419A1 (en) 2010-11-26 2012-05-31 Leo Pharma A/S Calcium-sensing receptor-active compounds
EP2683697B1 (en) 2011-03-10 2017-09-06 Lupin Atlantis Holdings SA Substituted morpholines as modulators for the calcium sensing receptor
SG193331A1 (en) 2011-03-18 2013-10-30 Lupin Ltd Benzo [b] [1, 4] oxazin derivatives as calcium sensing receptor modulators
NZ628627A (en) 2012-02-24 2017-02-24 Lupin Atlantis Holdings Sa Substituted chroman compounds as calcium sensing receptor modulators
WO2013136288A1 (en) 2012-03-16 2013-09-19 Lupin Limited Substituted 3,4-dihydro-2h-benzo[b] [1,4]oxazine compounds as calcium sensing receptor modulators
IN2015MN00421A (en) 2012-08-27 2015-09-04 Lupin Ltd
GB201217330D0 (en) 2012-09-28 2012-11-14 Univ Cardiff Therapeutic for treating inflammatory lung disorders
TW201602062A (en) 2013-08-12 2016-01-16 魯賓有限公司 Substituted biphenyl compounds as calcium sensing receptor modulators
WO2015028938A1 (en) 2013-08-28 2015-03-05 Lupin Limited Substituted naphthalene compounds as calcium sensing receptor modulators
WO2015162538A1 (en) 2014-04-21 2015-10-29 Lupin Limited Heterocyclic compounds as calcium sensing receptor modulators for the treatment of hyperparathyroidism, chronic renal failure and chronic kidney disease
WO2017037616A1 (en) 2015-08-31 2017-03-09 Lupin Limited Arylalkylamine compounds as calcium sensing receptor modulators
CN114901273A (en) 2019-12-27 2022-08-12 鲁平有限公司 Pharmaceutical compositions of CASR modulators and methods and uses thereof
US20230140054A1 (en) 2020-01-17 2023-05-04 Lupin Limited Methods, processes and intermediates for preparing chroman compounds

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3262977A (en) * 1962-03-10 1966-07-26 Chinoin Gyogyszer Es Vegyeszet N-aralkyl-1, 1-diphenyl-propylamine derivatives
MX9204881A (en) * 1991-08-23 1993-04-01 Nps Pharma Inc PHARMACEUTICAL COMPOSITION INCLUDING ACTIVE MOLECULES, RECEPTORS OF CALCIUM.
ES2218531T3 (en) * 1991-08-23 2004-11-16 Nps Pharmaceuticals, Inc. ACTIVE ARILALQUILAMINS ON CALCIUM RECEPTORS.
CN1254465C (en) 1996-04-09 2006-05-03 Nps医药公司 Calcilytic compounds
AU731146C (en) * 1996-05-01 2005-02-03 Nps Pharmaceuticals, Inc. Inorganic ion receptor-active compounds
EP0998283A1 (en) 1997-04-04 2000-05-10 Smithkline Beecham Corporation Calcilytic compounds
UY24949A1 (en) 1997-04-08 2001-04-30 Smithkline Beecham Corp CALCILITE COMPOUNDS
AR014975A1 (en) 1998-04-08 2001-04-11 Nps Pharma Inc CALCILITICAL COMPOUNDS, A PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS THEM, AND THE USE OF THEM FOR THE MANUFACTURE OF A MEDICINAL PRODUCT
PE20000415A1 (en) 1998-04-08 2000-05-21 Smithkline Beecham Corp CALCILITIC COMPOUNDS

Also Published As

Publication number Publication date
JP2004505949A (en) 2004-02-26
FR2812875B1 (en) 2003-12-12
WO2002012181A1 (en) 2002-02-14
JP4896350B2 (en) 2012-03-14
US20050192317A1 (en) 2005-09-01
EP1409453A1 (en) 2004-04-21
US7157498B2 (en) 2007-01-02
FR2812875A1 (en) 2002-02-15

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