AU2001282115A1 - Method and device for the measurement of chemical and/or biological samples - Google Patents

Method and device for the measurement of chemical and/or biological samples

Info

Publication number
AU2001282115A1
AU2001282115A1 AU2001282115A AU8211501A AU2001282115A1 AU 2001282115 A1 AU2001282115 A1 AU 2001282115A1 AU 2001282115 A AU2001282115 A AU 2001282115A AU 8211501 A AU8211501 A AU 8211501A AU 2001282115 A1 AU2001282115 A1 AU 2001282115A1
Authority
AU
Australia
Prior art keywords
unit
irradiation
sample
measurement
chemical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001282115A
Inventor
Leif Brand
Christian Eggeling
Karsten Gall
Rolf Gunther
Claus Seidel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evotec OAI AG
Original Assignee
Evotec OAI AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10040988A external-priority patent/DE10040988A1/en
Priority claimed from DE2001102218 external-priority patent/DE10102218A1/en
Application filed by Evotec OAI AG filed Critical Evotec OAI AG
Publication of AU2001282115A1 publication Critical patent/AU2001282115A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G01N2021/6419—Excitation at two or more wavelengths

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

A device for the measurement of chemical and/or biological samples, in particular by means of luminescence spectroscopy, comprises an irradiation unit (12), a sample receiver (10), at least one optical unit (30) and a detector unit (40). Electromagnetic radiation of various wavelength ranges and/or polarisations are led to the sample (10) from the irradiation unit (12). The colour marker in the sample (10), which contains at least one colour marker, is stimulated into producing luminescence and gives off light. The emitted light is led by means of an optical unit in the direction of an optical unit. The light emitted by the colour markers is detected by detectors (42,44,46, 48) in the detector unit. According to the invention, the measurement results may be improved on the irradiation unit (12) generating a pulsed irradiation. The irradiation unit is thus preferably controlled by a control unit (18) in such a way that the irradiation pulses impinge on the sample (10) in a temporal sequence.
AU2001282115A 2000-08-22 2001-08-22 Method and device for the measurement of chemical and/or biological samples Abandoned AU2001282115A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE10040988 2000-08-22
DE10040988A DE10040988A1 (en) 2000-08-22 2000-08-22 Measurement of chemical and/or biological samples, useful for screening interactions between two bio-molecules, comprises excitement of a marker with electromagnetic radiation of one wavelength or polarization from a pulsed transmitter
DE10102218 2001-01-19
DE2001102218 DE10102218A1 (en) 2001-01-19 2001-01-19 Measurement of chemical and/or biological samples, useful for screening interactions between two bio-molecules, comprises excitement of a marker with electromagnetic radiation of one wavelength or polarization from a pulsed transmitter
PCT/EP2001/009680 WO2002016911A1 (en) 2000-08-22 2001-08-22 Method and device for the measurement of chemical and/or biological samples

Publications (1)

Publication Number Publication Date
AU2001282115A1 true AU2001282115A1 (en) 2002-03-04

Family

ID=26006770

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001282115A Abandoned AU2001282115A1 (en) 2000-08-22 2001-08-22 Method and device for the measurement of chemical and/or biological samples

Country Status (6)

Country Link
EP (1) EP1311829B1 (en)
AT (1) ATE399989T1 (en)
AU (1) AU2001282115A1 (en)
DE (1) DE50114075D1 (en)
DK (1) DK1311829T3 (en)
WO (1) WO2002016911A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6552794B2 (en) * 2001-04-04 2003-04-22 Applied Spectral Imaging Ltd. Optical detection method for improved sensitivity
DE10221564A1 (en) * 2002-05-15 2003-11-27 Evotec Ag Photoluminescence analyzer for chemical and biological sample screening uses a high intensity homogeneous line image as illumination source, and has multiple sensor scanning of the image
AU2003298245A1 (en) * 2003-01-21 2004-08-13 Evotec Technologies Gmbh Method for analyzing the luminescence of chemical and/or biological samples
WO2006127692A2 (en) 2005-05-23 2006-11-30 Hess Harald F Optical microscopy with phototransformable optical labels
GB0715168D0 (en) * 2007-08-03 2007-09-12 Enigma Diagnostics Ltd Illumination apparatus for use in fluorescence-based detection
DE102010047237B4 (en) * 2010-08-13 2021-07-01 Leica Microsystems Cms Gmbh Method for separating detection signals in the beam path of an optical device

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3517241B2 (en) * 1993-01-18 2004-04-12 エボテック バイオシステムズ アクチェン ゲゼルシャフト Method and apparatus for evaluating the fitness of biopolymers
FI101829B (en) * 1995-03-07 1998-08-31 Erkki Juhani Soini Biospecific assay method
US5784157A (en) * 1995-11-21 1998-07-21 The Research Foundation Of State University Of New York Method and apparatus for identifying fluorophores
DE19634873A1 (en) * 1996-08-29 1998-03-12 Boehringer Mannheim Gmbh System for the differentiation of fluorescent groups of molecules by time-resolved fluorescence measurement
DE19718016A1 (en) * 1997-04-29 1998-11-05 Drexhage Karl Heinz Method for the optical detection of analyte molecules in a natural biological medium

Also Published As

Publication number Publication date
DE50114075D1 (en) 2008-08-14
EP1311829B1 (en) 2008-07-02
DK1311829T3 (en) 2008-10-27
WO2002016911A1 (en) 2002-02-28
ATE399989T1 (en) 2008-07-15
EP1311829A1 (en) 2003-05-21

Similar Documents

Publication Publication Date Title
WO1995021393A3 (en) Process and device for optically measuring a point on a sample with high local resolution
AU579143B2 (en) Method and apparatus for enhanced detection of electromagnetic signals
US5379103A (en) Method and apparatus for in situ detection of minute amounts of trace elements
Pakhomov et al. Laser-induced breakdown spectroscopy for detection of lead in concrete
RU2432615C2 (en) Detector and detection method
AU598367B2 (en) Sensing of methane
ATE213324T1 (en) METHOD AND DEVICE FOR DETERMINING ELECTROMAGNETIC WAVES emanating from a melt
CA2404624A1 (en) Improved luminescence characteristics detector
Solomonov et al. CLAVI pulsed cathodoluminescence spectroscope
AU2003245302A8 (en) Apparatus and method for differentiating multiple fluorescence signals by excitation wavelength
CS198190A3 (en) Process and apparatus for molten metal spectroscopic analysis
EP1855102B8 (en) Fluorescence detecting device and fluorescence detecting method
EP1067376A3 (en) Fluorescence measuring apparatus
GB1385791A (en) Atomic spectroscopy
WO2000019262A3 (en) High throughput microscopy
KR20050067428A (en) Method for authentication by chemical marking or tracing of an object or a substance
AU2003262608A1 (en) Photoacoustic detector
EP0324583A3 (en) Remote sensing system
AU2001282115A1 (en) Method and device for the measurement of chemical and/or biological samples
US7184143B2 (en) Method for remote sensing of pollutant molecules in a transparent medium using ultra-short intense lasers
EP1617440A4 (en) High-speed particle generator
WO2011129690A2 (en) A generator of terahertz radiation
DE502004008634D1 (en) METHOD AND DEVICE FOR SELECTION OF RECYCLING GLASS
Samek et al. Laser ablation for mineral analysis in the human body: integration of LIFS with LIBS
US20020015471A1 (en) X-ray fluorescence analyzer