AU2001271964A1 - Improved preparation of (4r, 5s, 6s)-3-(((2r,3r)-2-((((s)-2-amino-3-methyl-1-oxobutyl)methyl) tetrahydro-3-furanyl)thio)-6-((r)-1-hydroxyethyl)-4-methyl-7 -oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid - Google Patents

Improved preparation of (4r, 5s, 6s)-3-(((2r,3r)-2-((((s)-2-amino-3-methyl-1-oxobutyl)methyl) tetrahydro-3-furanyl)thio)-6-((r)-1-hydroxyethyl)-4-methyl-7 -oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid

Info

Publication number
AU2001271964A1
AU2001271964A1 AU2001271964A AU7196401A AU2001271964A1 AU 2001271964 A1 AU2001271964 A1 AU 2001271964A1 AU 2001271964 A AU2001271964 A AU 2001271964A AU 7196401 A AU7196401 A AU 7196401A AU 2001271964 A1 AU2001271964 A1 AU 2001271964A1
Authority
AU
Australia
Prior art keywords
methyl
oxobutyl
azabicyclo
hept
furanyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001271964A
Inventor
Zhong Li
Yang-I Lin
Tarek Mansour
Phaik-Eng Sum
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp filed Critical American Home Products Corp
Publication of AU2001271964A1 publication Critical patent/AU2001271964A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C07D477/08—Modification of a carboxyl group directly attached in position 2, e.g. esterification

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AU2001271964A 2000-07-13 2001-07-10 Improved preparation of (4r, 5s, 6s)-3-(((2r,3r)-2-((((s)-2-amino-3-methyl-1-oxobutyl)methyl) tetrahydro-3-furanyl)thio)-6-((r)-1-hydroxyethyl)-4-methyl-7 -oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid Abandoned AU2001271964A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21792500P 2000-07-13 2000-07-13
US60217925 2000-07-13
PCT/US2001/021721 WO2002006283A1 (en) 2000-07-13 2001-07-10 Improved preparation of (4r, 5s, 6s)-3-(((2r,3r)-2-((((s)-2-amino-3-methyl-1-oxobutyl)methyl)tetrahydro-3-furanyl)thio)-6-((r)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid

Publications (1)

Publication Number Publication Date
AU2001271964A1 true AU2001271964A1 (en) 2002-01-30

Family

ID=22813034

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001271964A Abandoned AU2001271964A1 (en) 2000-07-13 2001-07-10 Improved preparation of (4r, 5s, 6s)-3-(((2r,3r)-2-((((s)-2-amino-3-methyl-1-oxobutyl)methyl) tetrahydro-3-furanyl)thio)-6-((r)-1-hydroxyethyl)-4-methyl-7 -oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid

Country Status (5)

Country Link
US (1) US6649756B2 (en)
EP (1) EP1351960A1 (en)
JP (1) JP2004504322A (en)
AU (1) AU2001271964A1 (en)
WO (1) WO2002006283A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2569662A1 (en) * 2004-06-10 2005-12-22 Enkam Pharmaceuticals A/S Heparin binding peptide
WO2006035300A2 (en) * 2004-09-30 2006-04-06 Ranbaxy Laboratories Limited A process for the preparation of meropenem

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS609718B2 (en) * 1977-08-25 1985-03-12 塩野義製薬株式会社 Thiadiazolylthiosephalosporin related antibiotics
CA1125745A (en) * 1978-11-20 1982-06-15 Joseph Kaspi PROCESS FOR PREPARING .beta.-LACTAM ANTIBIOTICS
US5093464A (en) * 1988-12-01 1992-03-03 Korea Institute Of Science And Technology Wholly aromatic polyamide from N,N'-bis (4-amino phenyl)-isophthalamide
US5602118A (en) 1993-03-16 1997-02-11 American Cyanamid Company 2-thiosubstituted carbapenems
EP1023294B1 (en) * 1997-09-13 2003-02-12 Korea Institute of Science and Technology Carbapenem derivatives and a preparation method thereof

Also Published As

Publication number Publication date
US20020128283A1 (en) 2002-09-12
JP2004504322A (en) 2004-02-12
EP1351960A1 (en) 2003-10-15
WO2002006283A1 (en) 2002-01-24
US6649756B2 (en) 2003-11-18

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