AU2001268290A1 - Intramolecular glycosidation process for the synthesis of (2r, 2-alpha-r, 3a)-2-(1-(3,5-bis(trifluoromethyl)phenyl) ethoxy)-3-(4-fluorophenyl)-1,4-oxazine - Google Patents

Intramolecular glycosidation process for the synthesis of (2r, 2-alpha-r, 3a)-2-(1-(3,5-bis(trifluoromethyl)phenyl) ethoxy)-3-(4-fluorophenyl)-1,4-oxazine

Info

Publication number
AU2001268290A1
AU2001268290A1 AU2001268290A AU6829001A AU2001268290A1 AU 2001268290 A1 AU2001268290 A1 AU 2001268290A1 AU 2001268290 A AU2001268290 A AU 2001268290A AU 6829001 A AU6829001 A AU 6829001A AU 2001268290 A1 AU2001268290 A1 AU 2001268290A1
Authority
AU
Australia
Prior art keywords
oxazine
intramolecular
fluorophenyl
trifluoromethyl
ethoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001268290A
Inventor
Philip J. Pye
Kai Rossen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of AU2001268290A1 publication Critical patent/AU2001268290A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AU2001268290A 2000-06-12 2001-06-08 Intramolecular glycosidation process for the synthesis of (2r, 2-alpha-r, 3a)-2-(1-(3,5-bis(trifluoromethyl)phenyl) ethoxy)-3-(4-fluorophenyl)-1,4-oxazine Abandoned AU2001268290A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21101500P 2000-06-12 2000-06-12
US60211015 2000-06-12
PCT/US2001/018698 WO2001096320A1 (en) 2000-06-12 2001-06-08 Intramolecular glycosidation process for the synthesis of (2r, 2-alpha-r, 3a)-2-[1-(3,5-bis(trifluoromethyl)phenyl)ethoxy]-3-(4-fluorophenyl)-1,4-oxazine

Publications (1)

Publication Number Publication Date
AU2001268290A1 true AU2001268290A1 (en) 2001-12-24

Family

ID=22785248

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001268290A Abandoned AU2001268290A1 (en) 2000-06-12 2001-06-08 Intramolecular glycosidation process for the synthesis of (2r, 2-alpha-r, 3a)-2-(1-(3,5-bis(trifluoromethyl)phenyl) ethoxy)-3-(4-fluorophenyl)-1,4-oxazine

Country Status (3)

Country Link
US (1) US6403793B2 (en)
AU (1) AU2001268290A1 (en)
WO (1) WO2001096320A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2525650T3 (en) * 2008-02-26 2014-12-26 Sandoz Ag Preparation of morpholine derivatives
WO2012146692A1 (en) 2011-04-29 2012-11-01 Sandoz Ag Novel intermediates for the preparation of highly pure aprepitant or fosaprepitant
JP7242691B2 (en) 2017-11-03 2023-03-20 ウニヴェルシト・アミアン・ピカルディ・ジュール・ヴェルヌ Novel aminopyridinemethanol compound and use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5719147A (en) * 1992-06-29 1998-02-17 Merck & Co., Inc. Morpholine and thiomorpholine tachykinin receptor antagonists
GB9505491D0 (en) * 1995-03-18 1995-05-03 Merck Sharp & Dohme Therapeutic agents
GB9523244D0 (en) * 1995-11-14 1996-01-17 Merck Sharp & Dohme Therapeutic agents

Also Published As

Publication number Publication date
WO2001096320A1 (en) 2001-12-20
US6403793B2 (en) 2002-06-11
US20020016458A1 (en) 2002-02-07

Similar Documents

Publication Publication Date Title
AU2001263399A1 (en) 1-(pyrrlolidin-1-ylmethyl)-3-(pyrrol-2-ylmethylidene)-2-indo linone derivatives
HRP20020973A2 (en) Process for the synthesis of (2r,2-alpha-r,3a)-2-[1-(3,5-bis(trifluoromethyl)phenyl)ethoxy]-3-(4-fluorophenyl)-1,4-oxazine
AU2001289751A1 (en) Selective pde 2 inhibitors, used as medicaments for improving cognition
IL158693A0 (en) Azole compounds, process for preparation of the same and use thereof
TWI341313B (en) Process for the synthesis of 5-[[2(r)-[1(r)-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3(s)-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3h-1,2,4-triazol-3-one
AU2001266690A1 (en) Process for the synthesis of (2r, 2-alpha-r)-4-benzyl-2-(1-(3,5-bis(trifluoromethyl)phenyl) ethoxy)-1,4-oxazin-3-one
AU2001269749A1 (en) Trans-glycosidation process for the synthesis of (2r, 2-alpha-r, 3a)-2-(1-(3,5-bis(trifluoromethyl)phenyl) ethoxy)-3-(4-fluorophenyl)-1,4-oxazine
AU2002339192A1 (en) 1,2,4-triazole derivatives containing a sulphamate group as aromatase inhibitors
AU2002352962A1 (en) Novel-n-(4-(1h-imidazol-1-yl)-2-fluorophenyl)-3-(trifluoromethyl)-1-h-pyrazole-5-carboxamides as factor xa
IL153836A0 (en) Novel form of (r)-n-[5-methyl-8-(4-methylpiperazin-1-yl)-1,2,3,4-tetrahydro-2-naphthyl]-4-morpholinobenzamide
AU2001268290A1 (en) Intramolecular glycosidation process for the synthesis of (2r, 2-alpha-r, 3a)-2-(1-(3,5-bis(trifluoromethyl)phenyl) ethoxy)-3-(4-fluorophenyl)-1,4-oxazine
WO2002042367A3 (en) Fluorinated amino polyhedral borate compounds
IL155706A0 (en) Process for the preparation of (r)-5-(2-benzenesulfonylethyl)-3-(n-methylpyrrolidin-2-ylmethyl)-1h-indole
AU2001277801A1 (en) Process for preparing 2,3-diaminopropanols and synthesis of other compounds using 2,3-diaminopropanols
AU2003222435A1 (en) Process for the preparation of 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile
MXPA03006970A (en) New use of iloperidone.
AU2002230961A1 (en) Process for the synthesis of 1-(3,5-bis(trifluoromethyl)-phenyl)ethan-1-one
AU2003222399A1 (en) Process for the synthesis of base addition salts of 2,3-0-isopropylidene-1-0-substituted-5,6-dideoxy-5-n- (4-(2-hydroxy-2-oxoethyl)-phenylaminocarbonyl) amino-l-gulofuranosides
HK1051190A1 (en) Process for the preparation of 2-(4-alkyl-1-piperazinyl-benzaldehyde and -benzylidenyl compounds.
IL164377A (en) Methods of preparation of 2-(7-chloro-1,8-naphthyridine-2yl)-3-(5-methyl-2-oxo-hexyl)-1-isoindolinone
WO2004099129A3 (en) Intermediates useful in the synthesis of hiv-protease inhibitors and methods for preparing the same
AU2002300794A1 (en) Process for preparing 4,5-dihydro-1,3-thiazoles
AU5514199A (en) Process for the preparation of 2-(aryloxymethyl)-2,5,7,8-tetramethylchroman-6-ols
AU2003236207A1 (en) The hydrochloride of (s)-(+)-3-(1-(2-(1-acetyl-2,3-dihydro-1h-indol-3-yl)ethyl)-1,2,3,6-tetrahydropyridin-4-yl)-6-chloro-1h-indole
AU2002256002A1 (en) Process for 2,4-disubstituted-1,3,4-oxadiazoline-5-thione and 5-one compounds