AU2001267756A1 - Bifunctional agents possessing antioxidant and antiarrhythmic activity - Google Patents

Bifunctional agents possessing antioxidant and antiarrhythmic activity

Info

Publication number
AU2001267756A1
AU2001267756A1 AU2001267756A AU6775601A AU2001267756A1 AU 2001267756 A1 AU2001267756 A1 AU 2001267756A1 AU 2001267756 A AU2001267756 A AU 2001267756A AU 6775601 A AU6775601 A AU 6775601A AU 2001267756 A1 AU2001267756 A1 AU 2001267756A1
Authority
AU
Australia
Prior art keywords
sub
bifunctional agents
agents possessing
possessing antioxidant
antiarrhytmic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001267756A
Inventor
Theodora Calogeropoulou
Maria Koufaki
Alexandros Makriyannis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Uni Pharma Kleon Tsetis Pharmaceutical Laboratories SA
Original Assignee
Uni Pharma Kleon Tsetis Pharmaceutical Laboratories SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uni Pharma Kleon Tsetis Pharmaceutical Laboratories SA filed Critical Uni Pharma Kleon Tsetis Pharmaceutical Laboratories SA
Publication of AU2001267756A1 publication Critical patent/AU2001267756A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)

Abstract

The present invention relates to novel bifunctional agents possessing antioxidant and antiarrhytmic activity, methods for the synthesis of the same and their applications in treating ischemia-reperfusion injury, as well as a variety of disorders related to free radicals and/or arrhythmias. These bifunctional drugs should preferentially segregate in the membrane and produce their antiarrhytmic effects while, at the same time, help in protecting the membrane lipids by scavenging free radicals. The present invention comprises compounds represented by Formula (I), wherein R<SUB>1</SUB>, R<SUB>2</SUB>, R<SUB>3</SUB>, R<SUB>4</SUB>, R<SUB>5 </SUB>are further defined
AU2001267756A 2000-07-12 2001-07-04 Bifunctional agents possessing antioxidant and antiarrhythmic activity Abandoned AU2001267756A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GR20000100231 2000-07-12
GR20000100231A GR1003725B (en) 2000-07-12 2000-07-12 Bifunctional agents possessing antioxidant and antiarrhythmic activity
PCT/GR2001/000030 WO2002004438A1 (en) 2000-07-12 2001-07-04 Bifunctional agents possessing antioxidant and antiarrhythmic activity

Publications (1)

Publication Number Publication Date
AU2001267756A1 true AU2001267756A1 (en) 2002-01-21

Family

ID=10944322

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001267756A Abandoned AU2001267756A1 (en) 2000-07-12 2001-07-04 Bifunctional agents possessing antioxidant and antiarrhythmic activity

Country Status (14)

Country Link
US (1) US7115657B2 (en)
EP (1) EP1301504B1 (en)
AT (1) ATE281449T1 (en)
AU (1) AU2001267756A1 (en)
CA (1) CA2415523A1 (en)
DE (1) DE60106922T2 (en)
ES (1) ES2231514T3 (en)
GR (1) GR1003725B (en)
HU (1) HUP0303137A3 (en)
IL (1) IL153791A0 (en)
PL (1) PL203179B1 (en)
PT (1) PT1301504E (en)
RS (1) RS49976B (en)
WO (1) WO2002004438A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0519979A2 (en) * 2005-02-25 2009-08-18 Lilly Co Eli compound or stereoisomers, mixtures of stereoisomers or pharmaceutically acceptable salts thereof, pharmaceutical composition, and use of a compound
WO2012013816A1 (en) * 2010-07-30 2012-02-02 Medexis S.A. Compounds and methods for treating neoplasia
EP2747556B1 (en) 2011-08-23 2021-08-11 Vive Crop Protection Inc. Pyrethroid formulations
CA2882679C (en) 2011-12-22 2019-10-15 Vive Crop Protection Inc. Strobilurin formulations
RS55813B2 (en) 2012-07-12 2019-12-31 Khondrion Ip B V Chromanyl derivatives for treating mitochondrial disease
WO2016190852A1 (en) * 2015-05-26 2016-12-01 Stealth Peptides International, Inc. Therapeutic compositions including chromanyl compounds, variants and analogues thereof, and uses thereof
US11517013B2 (en) 2017-08-25 2022-12-06 Vive Crop Protection Inc. Multi-component, soil-applied, pesticidal compositions

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1338012C (en) * 1987-04-27 1996-01-30 John Michael Mccall Pharmaceutically active amines

Also Published As

Publication number Publication date
RS49976B (en) 2008-09-29
US7115657B2 (en) 2006-10-03
ATE281449T1 (en) 2004-11-15
IL153791A0 (en) 2003-07-31
HUP0303137A2 (en) 2004-01-28
YU100202A (en) 2006-01-16
HUP0303137A3 (en) 2005-02-28
WO2002004438A1 (en) 2002-01-17
CA2415523A1 (en) 2002-01-17
PL363148A1 (en) 2004-11-15
DE60106922T2 (en) 2005-11-03
DE60106922D1 (en) 2004-12-09
US20040259763A1 (en) 2004-12-23
GR1003725B (en) 2001-11-27
EP1301504A1 (en) 2003-04-16
ES2231514T3 (en) 2005-05-16
PL203179B1 (en) 2009-09-30
PT1301504E (en) 2005-02-28
EP1301504B1 (en) 2004-11-03

Similar Documents

Publication Publication Date Title
IL160440A (en) Dihydropteridinones, method for producing the same and the use thereof as medicaments
AU7278500A (en) Fungicides
CA2274464A1 (en) Ketobenzamides as calpain inhibitors
CA2356300A1 (en) 3-azabicyclo[3.1.0]hexane derivatives useful in therapy
IL164974A0 (en) Novel compounds and their use
MXPA02011370A (en) Substituted iminoazines.
PL345561A1 (en) Substituted benzoylcyclohexandiones
NZ320580A (en) Tricyclic compounds, preparation and pharmaceutical compositions thereof
HK1055117A1 (en) 8,8A-dihydro-indenoÄ11,2-dÜthiazole derivatives, amethod for their production and their use as medi caments.
PL363990A1 (en) Arylsulfonamides as antiviral agents
MXPA02009643A (en) Shortened synthesis of 3,3-diarylpropylamine derivatives.
AU2001267756A1 (en) Bifunctional agents possessing antioxidant and antiarrhythmic activity
CA2356985A1 (en) 5ht1 antagonists for antidepressant therapy
YU12000A (en) Substituted 1,2,3,4,,5,6,-hexahydro-2,6-methano-3- benzazocine-10-oles, method for the production and use thereof as medicaments
UA66866C2 (en) Synthesis of mopholine derivatives
IN187760B (en)
CA2258539A1 (en) Ring-fused dihydropyranes, process for the preparation and use thereof
ZA986680B (en) Thiazolobenzoheterocycles their preparation and medicaments containing them
DE69533298D1 (en) Dioxabicyclo 3.3.0 octane derivatives, e.g. Sesamin etc., for the prevention and relief of allergy symptoms
AU2002246814A1 (en) Substituted 4,5-dihydro-1,2,4-triazin-3-ones, 1,2,4-triazin-3-ones, and their use as fungicides and insecticides
CA2425368A1 (en) New sulphoxybenzamides
AU2910800A (en) Novel substituted 3-phenoxy and 3-phenylalkyloxy-2-phenyl-propylamines
AU2002210537A1 (en) (4-acylaminopiperidin-1-yl) acetamides as neurokinin antagonists
MY130771A (en) 3-azabicyclo [3.1.0] hexane derivatives useful in therapy.
CA2171972A1 (en) Heteroarylamino and heteroarylsulfonamido substituted 3-benzylaminomethyl piperidines and related compounds