AU2001266055A1 - Screening method for modulators of suv39h2-methyltransferase - Google Patents
Screening method for modulators of suv39h2-methyltransferaseInfo
- Publication number
- AU2001266055A1 AU2001266055A1 AU2001266055A AU6605501A AU2001266055A1 AU 2001266055 A1 AU2001266055 A1 AU 2001266055A1 AU 2001266055 A AU2001266055 A AU 2001266055A AU 6605501 A AU6605501 A AU 6605501A AU 2001266055 A1 AU2001266055 A1 AU 2001266055A1
- Authority
- AU
- Australia
- Prior art keywords
- suv39h2
- modulators
- methyltransferase
- screening method
- methyltransferase activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6875—Nucleoproteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
- C12N9/1007—Methyltransferases (general) (2.1.1.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/91005—Transferases (2.) transferring one-carbon groups (2.1)
- G01N2333/91011—Methyltransferases (general) (2.1.1.)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Cell Biology (AREA)
- Reproductive Health (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Murine and human Suv39h2 polypeptide and DNA molecules encoding them. <i>Suv39h2</i> is a novel member of the <i>Suv3-9</i> gene family. Suv39h2 is a novel component of meiotic higher order chromatin. It has histone methyltransferase activity and is required, in combination with Suv39h1, for male gametogenesis. Sub39h2 can be used in screening methods to identify modulators of its methyltransferase activity, which are useful in cancer therapy and for male contraception.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00112345 | 2000-06-09 | ||
EP00112479A EP1162460A1 (en) | 2000-06-09 | 2000-06-09 | Mammalian Suv39h2 proteins and isolated DNA molecules encoding them |
EP00112345A EP1162274A1 (en) | 2000-06-09 | 2000-06-09 | Method for identifying compounds modifying methyltransferase-dependent chromosome stability |
EP00112479 | 2000-06-09 | ||
PCT/EP2001/006520 WO2001094621A1 (en) | 2000-06-09 | 2001-06-08 | Screening method for modulators of suv39h2-methyltransferase |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001266055A1 true AU2001266055A1 (en) | 2001-12-17 |
Family
ID=26071033
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001274088A Abandoned AU2001274088A1 (en) | 2000-06-09 | 2001-06-07 | Screening-method for modulators of methyltransferase-dependent chromosome stability |
AU2001266055A Abandoned AU2001266055A1 (en) | 2000-06-09 | 2001-06-08 | Screening method for modulators of suv39h2-methyltransferase |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001274088A Abandoned AU2001274088A1 (en) | 2000-06-09 | 2001-06-07 | Screening-method for modulators of methyltransferase-dependent chromosome stability |
Country Status (7)
Country | Link |
---|---|
EP (2) | EP1294927B1 (en) |
JP (2) | JP4896344B2 (en) |
AT (1) | ATE310100T1 (en) |
AU (2) | AU2001274088A1 (en) |
DE (1) | DE60115039T2 (en) |
ES (1) | ES2252240T3 (en) |
WO (2) | WO2001094620A1 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2002359916A1 (en) * | 2001-12-27 | 2003-07-15 | Takeda Chemical Industries, Ltd. | Preventives/remedies for cancer |
GB0301450D0 (en) * | 2003-01-22 | 2003-02-19 | Medical Res Council | Protein crystal structure |
JP3913181B2 (en) * | 2003-02-06 | 2007-05-09 | 三菱重工業株式会社 | Carbon nanofiber manufacturing method and manufacturing apparatus |
JP5451376B2 (en) * | 2007-03-15 | 2014-03-26 | 株式会社リバース・プロテオミクス研究所 | Biomarkers specific for blood cell lineage or specific for osteoclast differentiation |
JP6064231B2 (en) * | 2011-06-03 | 2017-01-25 | オンコセラピー・サイエンス株式会社 | SUV39H2 as a target gene for cancer treatment and diagnosis |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999011667A1 (en) * | 1997-08-29 | 1999-03-11 | Innogenetics N.V. | METHYLATED, SmD HOMOLOGOUS PEPTIDES, REACTIVE WITH THE ANTIBODIES FROM SERA OF LIVING BEINGS AFFECTED WITH SYSTEMIC LUPUS ERYTHEMATOSUS |
-
2001
- 2001-06-07 DE DE60115039T patent/DE60115039T2/en not_active Expired - Lifetime
- 2001-06-07 JP JP2002502160A patent/JP4896344B2/en not_active Expired - Lifetime
- 2001-06-07 EP EP01940552A patent/EP1294927B1/en not_active Expired - Lifetime
- 2001-06-07 ES ES01940552T patent/ES2252240T3/en not_active Expired - Lifetime
- 2001-06-07 WO PCT/EP2001/006485 patent/WO2001094620A1/en active IP Right Grant
- 2001-06-07 AT AT01940552T patent/ATE310100T1/en active
- 2001-06-07 AU AU2001274088A patent/AU2001274088A1/en not_active Abandoned
- 2001-06-08 WO PCT/EP2001/006520 patent/WO2001094621A1/en not_active Application Discontinuation
- 2001-06-08 EP EP01943488A patent/EP1294928A1/en not_active Withdrawn
- 2001-06-08 AU AU2001266055A patent/AU2001266055A1/en not_active Abandoned
- 2001-06-08 JP JP2002502161A patent/JP2003535596A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
AU2001274088A1 (en) | 2001-12-17 |
JP2003535595A (en) | 2003-12-02 |
EP1294927A1 (en) | 2003-03-26 |
JP2003535596A (en) | 2003-12-02 |
ATE310100T1 (en) | 2005-12-15 |
JP4896344B2 (en) | 2012-03-14 |
DE60115039D1 (en) | 2005-12-22 |
DE60115039T2 (en) | 2006-07-27 |
EP1294927B1 (en) | 2005-11-16 |
WO2001094620A1 (en) | 2001-12-13 |
WO2001094621A1 (en) | 2001-12-13 |
ES2252240T3 (en) | 2006-05-16 |
EP1294928A1 (en) | 2003-03-26 |
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