AU2001265008A1 - Caspase inhibitors and uses thereof - Google Patents

Caspase inhibitors and uses thereof

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Publication number
AU2001265008A1
AU2001265008A1 AU2001265008A AU6500801A AU2001265008A1 AU 2001265008 A1 AU2001265008 A1 AU 2001265008A1 AU 2001265008 A AU2001265008 A AU 2001265008A AU 6500801 A AU6500801 A AU 6500801A AU 2001265008 A1 AU2001265008 A1 AU 2001265008A1
Authority
AU
Australia
Prior art keywords
caspase inhibitors
caspase
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001265008A
Inventor
Julian Golec
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vertex Pharmaceuticals Inc
Original Assignee
Vertex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Publication of AU2001265008A1 publication Critical patent/AU2001265008A1/en
Abandoned legal-status Critical Current

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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AU2001265008A 2000-05-23 2001-05-23 Caspase inhibitors and uses thereof Abandoned AU2001265008A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US20636200P 2000-05-23 2000-05-23
US60206362 2000-05-23
US21700600P 2000-07-10 2000-07-10
US60217006 2000-07-10
PCT/US2001/017075 WO2001090070A2 (en) 2000-05-23 2001-05-23 Caspase inhibitors and uses thereof

Publications (1)

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AU2001265008A1 true AU2001265008A1 (en) 2001-12-03

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AU2001265008A Abandoned AU2001265008A1 (en) 2000-05-23 2001-05-23 Caspase inhibitors and uses thereof

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US (1) US7053057B2 (en)
EP (1) EP1283827A2 (en)
JP (1) JP2003534325A (en)
KR (1) KR20020025959A (en)
AP (1) AP2002002407A0 (en)
AR (1) AR028619A1 (en)
AU (1) AU2001265008A1 (en)
CA (1) CA2380935A1 (en)
MX (1) MXPA02000823A (en)
NO (1) NO20020343L (en)
NZ (1) NZ516918A (en)
PE (1) PE20020058A1 (en)
PL (1) PL357713A1 (en)
SK (1) SK1192002A3 (en)
TR (1) TR200200767T1 (en)
WO (1) WO2001090070A2 (en)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA01010127A (en) 1999-04-09 2002-08-20 Cytovia Inc Caspase inhibitors and the use thereof.
ATE266623T1 (en) * 1999-08-06 2004-05-15 Vertex Pharma CASPASE INHIBITORS AND THEIR USE
BR0013666A (en) 1999-08-27 2002-05-14 Cytovia Inc "alpha" -hydroxy acids substituted for caspase inhibitors and their use
PE20011350A1 (en) 2000-05-19 2002-01-15 Vertex Pharma PROPHARMAC OF AN INHIBITOR OF INTERLEUKIN-1ß CONVERTER ENZYME (ICE)
US6878743B2 (en) 2001-09-18 2005-04-12 Sunesis Pharmaceuticals, Inc. Small molecule inhibitors of caspases
EP1485107A1 (en) 2002-02-11 2004-12-15 Vertex Pharmaceuticals Incorporated Phospholipids as caspase inhibitor prodrugs
EP1499898A2 (en) * 2002-04-19 2005-01-26 Vertex Pharmaceuticals Incorporated Regulation of tnf-alpha
CA2501196A1 (en) * 2002-10-10 2004-04-22 Becton, Dickinson And Company Sample collection system with caspase inhibitor
US20060241034A1 (en) * 2003-05-22 2006-10-26 David Chauvier Means for preventing and treating cellular death and their biological applications
AU2003902704A0 (en) * 2003-05-29 2003-06-19 Crc For Waste Management And Pollution Control Limited Of Unsw Process for producing a nanoscale zero-valent metal
AR047981A1 (en) * 2004-02-27 2006-03-15 Vertex Pharma CASPASA INHIBITORS AND THEIR CORRESPONDING USES
KR101135765B1 (en) 2004-03-12 2012-04-23 버텍스 파마슈티칼스 인코포레이티드 Processes and intermediates for the preparation of aspartic acetal caspase inhibitors
JP4691549B2 (en) * 2004-04-07 2011-06-01 ノバルティス アーゲー Inhibitors of IAP
JP5053836B2 (en) * 2004-04-30 2012-10-24 テラプトシス エス アー Caspase-2 inhibitors and their biological applications
JP4848367B2 (en) * 2004-05-15 2011-12-28 バーテックス ファーマシューティカルズ インコーポレイテッド Treatment of seizures using ICE inhibitors
EP2295054A1 (en) 2004-05-27 2011-03-16 Vertex Pharmaceuticals Incorporated Ice inhibitors for the treatment of autoinflammatory diseases
WO2006030437A2 (en) * 2004-09-17 2006-03-23 Biomas Ltd. Novel tellurium compounds and their use as immunomodulators
CA2616337A1 (en) * 2005-07-28 2007-02-08 Vertex Pharmaceuticals Incorporated Caspase inhibitor prodrugs
PE20110224A1 (en) 2006-08-02 2011-04-05 Novartis Ag PROCEDURE FOR THE SYNTHESIS OF A PEPTIDOMIMETIC OF Smac INHIBITOR OF IAP, AND INTERMEDIARY COMPOUNDS FOR THE SYNTHESIS OF THE SAME
WO2008063727A2 (en) * 2006-08-21 2008-05-29 United Therapeutics Corporation Combination therapy for treatment of viral infections
EP2102229B1 (en) 2006-10-12 2014-03-26 Novartis AG Pyrrolydine derivatives as iap inhibitors
WO2008106167A1 (en) * 2007-02-28 2008-09-04 Conatus Pharmaceuticals, Inc. Combination therapy comprising matrix metalloproteinase inhibitors and caspase inhibitors for the treatment of liver diseases
WO2008137567A1 (en) * 2007-05-01 2008-11-13 Cedars-Sinai Medical Center Caspase inhibitors in the treatment of infection-associated preterm delivery
CN102105485B (en) * 2008-05-21 2016-01-13 新世界实验室公司 Selectivity caspase inhibitors and uses thereof
WO2010133000A1 (en) 2009-05-21 2010-11-25 New World Laboratories Inc. Selective caspase inhibitors and uses thereof
US20140309172A1 (en) 2010-11-05 2014-10-16 Dagmar Ringe Ice inhibiting compounds and uses thereof
US9428845B1 (en) 2010-12-28 2016-08-30 Warp Drive Bio, Inc. Identifying new therapeutic agents
WO2012140500A1 (en) 2011-04-15 2012-10-18 New World Laboratories, Inc. Selective cysteine protease inhibitors and uses thereof
US9956260B1 (en) 2011-07-22 2018-05-01 The J. David Gladstone Institutes Treatment of HIV-1 infection and AIDS
WO2015175381A1 (en) 2014-05-12 2015-11-19 Conatus Pharmaceuticals, Inc. Treatment of the complications of chronic liver disease with caspase inhibitors
EP4289950A3 (en) 2015-01-09 2024-01-24 Revolution Medicines, Inc. Macrocyclic compounds that participate in cooperative binding and medical uses thereof
US9989535B2 (en) 2015-10-01 2018-06-05 Warp Drive Bio, Inc. Methods and reagents for analyzing protein-protein interfaces
WO2017079566A1 (en) 2015-11-05 2017-05-11 Conatus Pharmaceuticals, Inc. Caspase inhibitors for use in the treatment of liver cancer
KR20180101418A (en) 2015-12-31 2018-09-12 코나터스 파마슈티칼스, 인크. Methods of using caspase inhibitors in the treatment of liver disease
AU2017249412B2 (en) 2016-04-12 2022-07-07 Ginkgo Bioworks, Inc. Compositions and methods for the production of compounds
CN105853408B (en) * 2016-04-15 2018-12-04 浙江大学 Benzoyl amine derivative is preparing the application in Caspase-1 inhibitor
TW201739734A (en) * 2016-05-11 2017-11-16 Chia Tai Tianqing Pharmaceutical Group Co Ltd Caspase inhibitor and pharmaceutical composition, use and therapeutic method thereof
CA3039283A1 (en) 2016-10-05 2018-04-12 Novartis Ag Combination compositions comprising fxr agonists for treating or preventing a fibrotic,cirrhotic disease or disorder
WO2018081592A2 (en) 2016-10-28 2018-05-03 Warp Drive Bio, Inc. Compositions and methods for the production of compounds
TWI764977B (en) * 2017-01-23 2022-05-21 大陸商正大天晴藥業集團股份有限公司 Bicyclic compound as CASPASE inhibitor, pharmaceutical composition containing same and use thereof
CN109748843B (en) * 2017-11-06 2022-11-11 正大天晴药业集团股份有限公司 Caspase inhibitors, pharmaceutical compositions, uses and methods of treatment thereof
CA3160142A1 (en) 2019-11-04 2021-05-14 Revolution Medicines, Inc. Ras inhibitors
CN115873020A (en) 2019-11-04 2023-03-31 锐新医药公司 RAS inhibitors
WO2021091982A1 (en) 2019-11-04 2021-05-14 Revolution Medicines, Inc. Ras inhibitors
PE20231207A1 (en) 2020-09-15 2023-08-17 Revolution Medicines Inc INDOLIC DERIVATIVES AS RAS INHIBITORS IN CANCER TREATMENT
WO2022123062A1 (en) 2020-12-11 2022-06-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Blocking caspase and/or fasl for preventing fatal outcome in covid-19 patients

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991015577A1 (en) 1990-04-04 1991-10-17 Black, Roy, A. INTERLEUKIN 1'beta' PROTEASE
US5866545A (en) * 1993-08-13 1999-02-02 Merck & Co., Inc. Substituted ketone derivatives as inhibitors of interleukin-1β converting enzyme
WO1997024339A1 (en) * 1995-12-27 1997-07-10 Ono Pharmaceutical Co., Ltd. Tetrazole derivatives and drugs containing the same as the active ingredient
CN1138472C (en) * 1997-10-10 2004-02-18 西托维亚公司 Dipeptide apoptosis inhibitors and the use thereof
JP2002506829A (en) 1998-03-16 2002-03-05 サイトビア インコーポレイテッド Apoptosis inhibitors of dipeptides and their uses
US6045990A (en) * 1998-07-09 2000-04-04 Baust; John M. Inclusion of apoptotic regulators in solutions for cell storage at low temperature

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