AU2001263251A1 - Method for treatment of tumors using nucleic acid ligands to pdgf - Google Patents

Method for treatment of tumors using nucleic acid ligands to pdgf

Info

Publication number
AU2001263251A1
AU2001263251A1 AU2001263251A AU6325101A AU2001263251A1 AU 2001263251 A1 AU2001263251 A1 AU 2001263251A1 AU 2001263251 A AU2001263251 A AU 2001263251A AU 6325101 A AU6325101 A AU 6325101A AU 2001263251 A1 AU2001263251 A1 AU 2001263251A1
Authority
AU
Australia
Prior art keywords
pdgf
tumors
treatment
nucleic acid
acid ligands
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001263251A
Inventor
Carl-Henrik Heldin
Arne Ostman
Kristian Pietras
Kristofer Rubin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gilead Sciences Inc
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of AU2001263251A1 publication Critical patent/AU2001263251A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/04—Methods of creating libraries, e.g. combinatorial synthesis using dynamic combinatorial chemistry techniques
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
AU2001263251A 2000-05-17 2001-05-17 Method for treatment of tumors using nucleic acid ligands to pdgf Abandoned AU2001263251A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20500600P 2000-05-17 2000-05-17
US60205006 2000-05-17
PCT/US2001/016078 WO2001087351A1 (en) 2000-05-17 2001-05-17 Method for treatment of tumors using nucleic acid ligands to pdgf

Publications (1)

Publication Number Publication Date
AU2001263251A1 true AU2001263251A1 (en) 2001-11-26

Family

ID=22760392

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001263251A Abandoned AU2001263251A1 (en) 2000-05-17 2001-05-17 Method for treatment of tumors using nucleic acid ligands to pdgf

Country Status (2)

Country Link
AU (1) AU2001263251A1 (en)
WO (1) WO2001087351A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8039443B2 (en) 2002-11-21 2011-10-18 Archemix Corporation Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics
US10100316B2 (en) 2002-11-21 2018-10-16 Archemix Llc Aptamers comprising CPG motifs
US8853376B2 (en) 2002-11-21 2014-10-07 Archemix Llc Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics
EP1620547B1 (en) * 2003-04-21 2014-06-18 Archemix LLC Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics
CN102813923B (en) 2003-08-27 2015-04-01 奥普索特克公司 Combination therapy for the treatment of ocular neovascular disorders
US7803931B2 (en) 2004-02-12 2010-09-28 Archemix Corp. Aptamer therapeutics useful in the treatment of complement-related disorders
BRPI0509911A (en) * 2004-04-13 2007-09-18 Osi Eyetech Inc method for inhibiting the activity of a separate site of an aptamer binding site in a ligand, methods of increasing the antagonist, receptor, ligand-binding aptamer, antagonist, ligand of a receptor-binding aptamer a vegf aptamer, and a vegfr aptamer ligand, method to increase an antagonist property of an aptamer that targets a protein that interacts with a second protein, method to identify an aptamer conjugate, methods to release a biologically molecule active, nucleic acid, an aptamer, and an anti-vegf aptamer to an eye, compound, composition to release a biologically active molecule to an eye
EP1807107B1 (en) * 2004-11-02 2011-09-07 Archemix Corp. Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics
SG10201708882TA (en) 2013-07-12 2017-12-28 Ophthotech Corp Methods for treating or preventing ophthalmological conditions

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6229002B1 (en) * 1995-06-07 2001-05-08 Nexstar Pharmaceuticlas, Inc. Platelet derived growth factor (PDGF) nucleic acid ligand complexes

Also Published As

Publication number Publication date
WO2001087351A1 (en) 2001-11-22

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