AU2001263002A1 - Unit dose blister package with keyhole opening - Google Patents
Unit dose blister package with keyhole openingInfo
- Publication number
- AU2001263002A1 AU2001263002A1 AU2001263002A AU2001263002A AU2001263002A1 AU 2001263002 A1 AU2001263002 A1 AU 2001263002A1 AU 2001263002 A AU2001263002 A AU 2001263002A AU 2001263002 A AU2001263002 A AU 2001263002A AU 2001263002 A1 AU2001263002 A1 AU 2001263002A1
- Authority
- AU
- Australia
- Prior art keywords
- package
- blister
- layer
- cover layer
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Description
UNIT DOSE BLISTER PACKAGE WITH KEYHOLE OPENING
BACKGROUND OF THE INVENTION This invention relates generally to packaging and more particularly to child-resistant blister packages.
Various packages have been disclosed in the patent literature and many are commercially available for holding one or more medicaments therein.
For example, United States Letters Patent No. 3,780,856 (Braverman) discloses a medicinal dispensing package comprising a base member having plurality of units, each made up of flanges having corners and surrounding a chamber for holding a drug therein. The units are detachably connected along perforated lines so that one flange may be separated from the others. A closure sheet having perforated lines corresponding to the perforated lines of the base member is secured, via areas of adhesive on it, to the flanges of the units to cover each unit. The central areas of the closure sheet disposed over each of the chambers do not have any adhesive. Selected corners of the base member are cut away so that one corner of the closure sheet overlying unit can be readily lifted as a tab to gain entry into the chamber.
In United States Letters Patent No. 4,398,634 (McClosky) there is disclosed a child-proof package system including multiple sealed units that are separately interconnected to one another by tear lines. Each of the units includes opposed, substantially planar, tear resistant flexible plastic sheets heat sealed to each other about peripheral seal zones to form a compartment for a drug. The seal zones between adjacent compartments include tear lines for permitting separation of discrete sealed units from each other without disrupting the integrity of the compartments. Each tear line includes a substantially linear, continuous slit uninterrupted by bridge areas and being linearly aligned with the compartments of adjacent units. The linear dimension of each of the continuous slits is greater than the greatest linear dimension of the linearly aligned compartments as measured parallel to the continuous slit.
In United States Letters Patent No. 5,551,567 (Malone et al.) there is disclosed a package having plural blister units, each of which includes a well adapted to hold a medicinal dosage therein. Score lines are surrounding each well to define the boundaries of each unit. A cover having plural score lines corresponding to the score lines of the blister is located over the blister to seal the dosage within the wells. Each of the units is separable from the other units by tearing it along its score lines. A short score line is provided in each blister unit and it extends into communication with the score lines separating the units. The short score line of each unit serves as the means for tearing an individual unit open to gain access to the dosage therein.
Other blister packages, some of which are disclosed to be "child-proof, are shown in the following United States Letters Patent Nos.: 4,011,949 (Braber et al.), 4,243, 144(Margulies), 4,294,361 (Margulies et al.), 4,398,635 (Hirt), 4,506,789 (Dlugosz), 4,537,312 (Intini), 5,046,618 (Wood), 5,172,812 (Wharton et al.), 5,310,060 (Bitner et al.), 5, 325,968 (Sowden), 5,339,960
(Price), 5,469,968 (Matthews et al.), 5,472,093 (Nugent et al.), 5,529,188 (Coggswell), 5,613,609 (Hamilton et al.), 5,758,774 (Leblong), 5,775,505 (Vasquez et al.), 5,785,180 (Dressel), 5,862,915 (Plezia et al.), 5,878,887 (Parker et al.), 5,878,888 (Faughey et al.), 5,894,930 (Faughey et al.), 5,938,032 (Svec et al.) and 5,944,191 (Ray et al.)
While the packages of the foregoing patents may be generally suitable for their intended purposes, they each appear to leave something to be desired from the standpoint of providing a unit-dose package which is easy to open by an adult, but which is resistant to opening by a child (e.g., is "child-proof) is simple in construction and low in cost.
SUMMARY OF THE INVENTION In accordance with one aspect of this invention there is provided a child- resistant blister package for unit dose products, e.g., medicaments. The package basically comprising a blister layer and a cover layer. The blister layer is formed of a planar material, e.g., thermoformable or cold-formable webstock, and has at least one perforated line and at least two cells or units contiguous with its perforated line. The cells of the blister layer have a peripheral planar flanged portion and a blister portion projecting from the
flanged portion to form a cavity in which the unit dose product is to be located. The cover layer is formed of a planar material, e.g., aluminum or other metal foil in either a single ply or a lamination, and has at least one perforated line and at least two cells contiguous with its perforated line. Each cell of the cover layer is the same shape and size as a corresponding cell of the blister layer.
The cover layer is fixedly, e.g., adhesively, secured to the blister layer along the flanged portions, with the at least one perforated line of the cover layer being coincident with the at least one perforated line of the blister layer and with the cells of the cover layer being coincident with the cells of the blister layer.
The blister layer additionally comprises a generally keyhole shaped opening in at least one of its cells. The keyhole shaped opening comprising an elongated, e.g., 3 mm, linear slit having a pair of ends and a hole, e .g., a 1 mm circular hole, at a first one of the pair of ends of the slit. The keyhole shaped opening is located in the cell of the blister layer so that the first one of said pair of ends is located adjacent but spaced by a gap of a predetermined length, e.g., approximately 1 mm, slightly from the at least one perforated line of the blister layer, and with the hole being located spaced, e.g., 4 mm, from but directed toward the cavity of that cell. When so constructed the package is resistant to tearing by a child, but is tearable by an adult along the at least one aligned perforated lines and from there across the gap to the slit in the keyhole shaped opening.
DESCRIPTION OF THE DRAWING Fig. 1 is a top plan view of one exemplary embodiment of a child resistant blister package constructed in accordance with this invention;
Fig. 2 is a bottom plan view of the embodiment of the package shown in Fig. 1 ;
Fig. 3 is an enlarged sectional view taken along line 3 - 3 of Fig. 1 ; and Fig. 4 is a bottom plan view of a second embodiment of the package. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT Referring now to the various figures of the drawing wherein like reference characters refer to like parts, there is shown at 20 in Fig. 1 one embodiment of a package constructed in accordance with this invention. The package 20 provides a means for the delivery of unit-doses of medicaments 10 (Fig. 3) that is tamper-proof, child-resistant, yet readily openable by adults, airtight, uses conventional packaging materials, and is simple in construction and economical. As can be seen from the figures, the package 20 is of the
"blister" type for holding individual dosages of the medicament 10 therein. Each dosage is separately packaged within its own unit or cell 22 for delivery to a patient. The cells 22 are releasably secured to each other by perforated lines (to be described later) so that any cell can be removed from the remaining cells of the package, and then opened to provide access to the medicament 10 within that cell.
In the exemplary embodiment of the package 20 shown herein there are twelve cells or units 22, in an array of three rows of four columns of like units. In this embodiment each of the twelve cells is identically constructed and each contains a unit-dose of the medicament 10 held in its own cavity 26 of a blister layer of material (to be described later) forming the package 20. If desired, the central two cells 22 may be blank so that only the ten peripherally located ones of the cells 22 of the array have a blister cavity 26 for containing a dose of the medicament. Thus, it should be noted at this juncture that the arrangement of cells shown in Fig. 1 is merely exemplary of any number of packages that may be constructed in accordance with this invention to include as many rows and columns of medicament containing cells 22 as desired.
The blister package 20 comprises of two layers of materials. The "top" layer, shown in Fig. 1, is a "blister" sheet 28 (Figs. 1 and 3) formed of a substantially rigid material, e.g., any conventional thermoformed material used in blister packaging, such as plastic, or cold-formable materials, such as foils or plastics. Moreover, the material may be a single ply or mulitiple plies or laminations. In one preferred embodiment of this invention the top layer 28 is formed as a single ply of polyvinylchloride. In any case, the top layer 28, is a planar sheet of a generally rectangular shape having a peripheral marginal edge 30. The corners of the layer 28 are rounded in the interests of safety.
As best seen in Fig. 1, the top layer 28 includes a grid of plural perforated lines 32. The lines extend through the thickness of the layer 28, across its full width and height, and intersect one another at equidistantly spaced locations to define therebetween the respective medicament holding cells 22. As mentioned earlier the top layer includes respective cavities 26 for the medicaments 10. In particular, the top layer 28 includes a plurality of raised hollow projections or "blisters," each centered between the intersecting perforated lines 32 forming the cells 22. The portions of the top layer 28 within the confines of the intersecting perforated lines 32 of each of the cells 22 is in the form of a planar peripheral flange 34 surrounding the blister of that cell.
Each of the blisters, being hollow, forms the heretofore identified cavity 26 within its interior.
In the embodiment shown herein each of the blisters is of a general flat oval shape as best seen in Figs. 1 and 3. This shape is conducive for accommodating a capsule or caplet shaped medicament 10, like shown in Fig
3. As will be appreciated by those skilled in the art the shape of the blisters or cavities 26 is purely a matter of choice, depending upon the shape of the medicament to be held therein. Thus, this invention contemplates packages having blisters or cavities of any geometric shape and/or size, to accommodate medicaments which are round, caplet, gelcap, ultratab, oblong, rectangular, triangular, pentagonal, octagonal or any other geometrically feasible shape and/or size.
The top layer 28, with the medicaments 10 located in its cavities 26, is sealed by a closure sheet or bottom layer 36. The bottom layer 36 is a thin planar sheet of the same size and profile as the top layer 28 and can be formed of any suitable material(s), such as metal foil (e.g., aluminum), plastic, metalized film, and/or paper stock , in single or multiple plies or laminations of one or more of the foregoing. The bottom sheet includes a grid of plural intersecting perforated lines 38. The perforated lines 38 extend through the thickness of the layer 36, across its full width and height, and intersect one another at equidistantly spaced locations coincident with the perforated lines 32 of the top layer 28 to define therebetween the respective medicament holding units or cells 22. The bottom layer 36 is adhesively secured to the top layer 28 by an adhesive layer 40 (Fig. 3) at the interface of the top surface of the flanges 34 of the top layer 28 and the under-surface of the bottom layer 36.
The materials making up the top and bottom layers 28 and 36, respectively, are sufficiently tear-resistant that the package 20 is resistant to being torn apart or opened at places other than the coincident perforated lines 32 and 38. Even tearing the package along the perforated lines will not provide access to the medicament contents of any of the cells 22 (all it may do is to separate the particular cell 22, whose margins are formed by the perforated lines that are torn, from the remainder of the package). To gain access to the contents of the cavity of the selected cell 22 requires an additional or second tearing step. This second step is one that cannot be readily accomplished by a young child, but which can be readily accomplished
by an adult by making use of a tear facilitating opening 40 (to be described hereinafter) in the top layer of that cell.
In particular, the top layer 28 includes a plurality of key-hole shaped, tear facilitating openings 40, one for each unit 22. Each tear-facilitating opening 40 comprises a short, e.g., 3 mm, linear slit 42 having a first end 46 and a second end at which a small, e.g., 1 mm, circular opening or hole 48 is located. Each opening 40 is located in the top layer 28 in the area forming a respective one of the cells 22, with the first end 46 of its slit 42 being located slightly spaced, e.g., 1 mm, inward of the perforated line 32 forming an inner marginal edge of the cell 22. This space forms a short bridgeable gap 50. The slit 42 is oriented so that it extends perpendicular to its associated perforated line 32. The circular opening 48 is located slightly spaced, e.g., 4 mm, from the cavity 26.
As shown in Fig. 4, the tear-facilitating opening 40 can be included in the bottom layer 36 coincident to the tear-facilitating opening in the blister layer
28. However the child resistant features of the present invention can be accomplished by including the tear-facilitating opening 40 in only the blister layer 28.
In order to gain access to any of the cells 22, the perforated line defining one of the boundaries of that unit must first be torn. This action can be accomplished by tearing at least two intersecting perforated lines to physically separate the desired cell from the remainder of the package, or by tearing along only one perforated line to provide access to the cell, while still leaving
the cell secured to one or more of the other cells of the package. In either case, once the line adjacent the tear facilitating opening 40 has been freed (torn) to provide access to a side of the cell 22 containing the medicament 10 to be dispensed, the cell's blister can be opened by tearing on its flange 34 contiguous with the gap 50. An adult will have the strength and coordination to breach the gap (tear the materials of the top and bottom layer along the length of the gap), a young child will not. Thus, a young child should not be able to open the blister to gain access to the medicament, even if the child is able to tear the cell 22 from the other cells of the package. Once the gap 50 has been breached by the user tearing it, the tear propagates down the linear slit 42 to the circular opening 48 at the opposite end of the slit. Continued tearing on the cell 22 causes the tear to propagate in any radial direction from the opening 48 to the blister a short distance away, with the direction of the tear being dependent upon the direction of the tearing force applied by the user. The medicament can then be removed from the breached blister (cavity).
As should be appreciated by the foregoing the package of this invention is simple in construction, can be made economically, provides a protective environment for medicaments, and can be readily opened without the use of utensils, such as a scissors or knives. Moreover, owing to the fact that two tearing operations have to be accomplished to gain access to any of the medicaments in the package renders the package of the subject invention
particularly suitable for limited access or child-resistant applications, e.g., holding medium to high toxicity drugs and the like.
Without further elaboration the foregoing will so fully illustrate our invention that others may, by applying current or future knowledge, adopt the same for use under various conditions of service.
Claims (27)
1. A child-resistant blister package for unit dose products, said package comprising a blister layer and a cover layer, said blister layer being formed of a planar material and having at least one perforated line and at least two cells contiguous with said perforated line of said blister layer, said cells having a peripheral planar flanged portion and a blister portion projecting from said flanged portion to form a cavity in which a product is to be located, said cover layer being formed of a planar material and having at least one perforated line and at least two cells contiguous with said perforated line of said cover layer, each cell of said cover layer being of the same shape and size as a corresponding cell of said blister layer, said cover layer being fixedly secured to said blister layer along said flanged portions, with said at least one perforated line of said cover layer being aligned with said at least one perforated line of said blister layer and with said cells of the cover layer being coincident with said cells of said blister layer, said blister layer additionally comprising a generally keyhole shaped opening in at least one of its cells, said keyhole shaped opening comprising an elongated slit having a pair of ends and a hole at a first one of said pair of ends of said slit, said keyhole shaped opening being located in said cell so that said first one of said pair of ends is located adjacent but spaced by a gap of a predetermined length slightly from said at least one perforated line, and with said hole being located directed toward said blister portion, said package being resistant to tearing by a child, but tearable by an adult along said at least one aligned perforated lines and from there across said gap to said slit of said keyhole shaped opening.
2. The package of Claim 1 wherein said perforated line of said blister layer divides said blister layer into said at least two cells.
3. The package of Claim 1 wherein said perforated line of said cover layer divides said cover layer into said at least two cells.
4. The package of Claim 2 wherein said perforated line of said cover layer divides said cover layer into said at least two cells.
5. The package of Claim 1 wherein said package has a peripheral edge and wherein none of said keyhole shaped opening is in communication with said peripheral edge.
6. The package of Claim 6 wherein each of said slits is linear.
7. The package of Claim 1 wherein each of said slits is approximately 3 mm long.
8. The package of Claim 1 wherein said hole is circular.
9. The package of Claim 8 wherein said circular hole is approximatelyl mm in diameter.
10. The package of Claim 6 wherein said hole is circular.
11. The package of Claim 10 wherein each of said slits is approximately 3 mm long and wherein said circular hole is approximately 1 mm in diameter.
12. The package of Claim 1 wherein said hole of said keyhole shaped opening is located approximately 4 mm from said cavity.
13. The package of Claim 11 wherein said hole of said keyhole shaped opening is located approximately 4 mm from said cavity.
14. The package of Claim 1 wherein said gap is approximately 1 mm long.
15. The package of Claim 11 wherein said hole of said keyhole shaped opening is located approximately 4 mm from said blister.
16. The package of Claim 15 wherein said gap is approximately 1 mm long.
17. The package of Claim 1 wherein said blister layer is formed of a thermoformable material.
18. The package of Claim 17 wherein said thermoformable material is a plastic.
19. The package of Claim 17 wherein said blister layer is formed of a cold-formable material.
20. The package of Claim 18 wherein said cold-formable material comprises a metal foil in a single or multiply plies or laminate.
21. The package of Claim 18 wherein said cold-formable material comprises a plastic in a single or multiple plies or laminate.
22. The package of Claim 1 wherein said cover layer comprises a metal foil in a single or multiple plies or laminate.
23. The package of Claim 1 wherein said cover layer comprises a metalized film in a single or multiple plies or laminate.
24. The package of Claim 1 wherein said cover layer comprises a plastic film in a single or multiple plies or laminate.
25. The package of Claim 22 wherein said metal foil is aluminum.
26. The package of Claim 1 wherein each of said blister portions is of a shape generally conforming to the shape of the product disposed within its chamber.
27. The package of claim 1 wherein said cover layer additionally comprises a generally keyhole shaped opening coincident to said generally keyhole shaped opening in said blister layer.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/611,404 | 2000-07-06 | ||
US09/611,404 US6352158B1 (en) | 2000-07-06 | 2000-07-06 | Unit dose blister package with keyhole assisted opening feature |
PCT/US2001/014802 WO2002004314A1 (en) | 2000-07-06 | 2001-05-08 | Unit dose blister package with keyhole opening |
Publications (2)
Publication Number | Publication Date |
---|---|
AU2001263002A1 true AU2001263002A1 (en) | 2002-04-18 |
AU2001263002B2 AU2001263002B2 (en) | 2005-05-26 |
Family
ID=24448886
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001263002A Expired AU2001263002B2 (en) | 2000-07-06 | 2001-05-08 | Unit dose blister package with keyhole opening |
AU6300201A Pending AU6300201A (en) | 2000-07-06 | 2001-05-08 | Unit dose blister package with keyhole opening |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU6300201A Pending AU6300201A (en) | 2000-07-06 | 2001-05-08 | Unit dose blister package with keyhole opening |
Country Status (15)
Country | Link |
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US (1) | US6352158B1 (en) |
EP (1) | EP1301415B1 (en) |
JP (1) | JP3693996B2 (en) |
AT (1) | ATE263720T1 (en) |
AU (2) | AU2001263002B2 (en) |
CA (1) | CA2413034C (en) |
DE (1) | DE60102699T2 (en) |
DK (1) | DK1301415T3 (en) |
ES (1) | ES2214421T3 (en) |
MX (1) | MXPA02011884A (en) |
NZ (1) | NZ522950A (en) |
PT (1) | PT1301415E (en) |
TR (1) | TR200400876T4 (en) |
WO (1) | WO2002004314A1 (en) |
ZA (1) | ZA200209646B (en) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1474556A1 (en) * | 2002-02-13 | 2004-11-10 | The Procter & Gamble Company | Dispensing of rinse additives into the rinse cycle during automatic machine laundering of fabrics |
US7086110B2 (en) * | 2002-02-13 | 2006-08-08 | The Procter & Gamble Company | Selective dispensing of laundry additives during automatic machine laundering of fabric |
US7340790B2 (en) * | 2002-02-13 | 2008-03-11 | Procter & Gamble Company | Universal dispenser for dispensing of laundry additives during automatic machine laundering of fabrics |
US7716956B2 (en) * | 2002-12-20 | 2010-05-18 | The Procter & Gamble Company | Attachment means |
US7168273B2 (en) * | 2002-11-07 | 2007-01-30 | The Procter & Gamble Company | Selective dispensing apparatus |
MXPA04007817A (en) * | 2002-02-13 | 2004-10-15 | Procter & Gamble | Sequential dispensing of laundry additives during automatic machine laundering of fabrics. |
GB2386130A (en) * | 2002-03-06 | 2003-09-10 | Reckitt Benckiser Nv | Detergent dosing delay device for a dishwasher |
US6818269B2 (en) * | 2002-09-27 | 2004-11-16 | Dot Packaging Group, Inc. | Metallic board |
GB2397799B (en) * | 2003-01-29 | 2006-03-15 | Rexam Med Packaging Ltd | Laminates and packaged produced therefrom |
US20040245145A1 (en) * | 2003-06-03 | 2004-12-09 | Urban Joseph J. | Method and article for packaging dosed products |
CN1890360A (en) * | 2003-12-03 | 2007-01-03 | 宝洁公司 | Automatic machine washing for woven fabric |
DE102004062864A1 (en) * | 2004-12-21 | 2006-06-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | foil container |
MX2007008575A (en) * | 2005-01-14 | 2007-09-07 | Cima Labs Inc | Non-tearable child resistant blister package. |
GB2425115A (en) * | 2005-04-15 | 2006-10-18 | Vectura Group Plc | Blister pack |
US20060249422A1 (en) * | 2005-05-05 | 2006-11-09 | Bates Ronald R Jr | Child-resistant blister package with tear tab |
WO2007100820A2 (en) * | 2006-02-28 | 2007-09-07 | Sharp Corporation | Child-resistant packaging for pharmaceutical products |
BRPI0709692A2 (en) * | 2006-03-31 | 2011-07-19 | Wyeth Corp | tear and leak resistant packaging for controlled dispensing of liquids |
US7866475B2 (en) * | 2006-06-12 | 2011-01-11 | Mcneil-Ppc, Inc. | Blister package |
WO2008149457A1 (en) * | 2007-06-08 | 2008-12-11 | Seirin Corporation | Packing container of acupuncture moxibustion needle |
WO2011010594A1 (en) * | 2009-07-21 | 2011-01-27 | 株式会社ヤマシタワークス | Press-through package and method of removing medication from same |
US9073882B2 (en) | 2010-10-27 | 2015-07-07 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
EP2632464B1 (en) | 2010-10-29 | 2015-04-29 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
WO2013028474A1 (en) | 2011-08-19 | 2013-02-28 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
EP2755656B1 (en) | 2011-09-16 | 2016-09-07 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US8999990B2 (en) | 2011-10-25 | 2015-04-07 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
WO2013062900A1 (en) | 2011-10-25 | 2013-05-02 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US9108947B2 (en) | 2011-10-31 | 2015-08-18 | Merck Sharp & Dohme Corp. | Inhibitors of the Renal Outer Medullary Potassium channel |
US9493474B2 (en) | 2011-10-31 | 2016-11-15 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US9139585B2 (en) | 2011-10-31 | 2015-09-22 | Merck Sharp & Dohme Corp. | Inhibitors of the Renal Outer Medullary Potassium channel |
EP2589365A1 (en) | 2011-11-03 | 2013-05-08 | LEK Pharmaceuticals d.d. | Child resistant and senior friendly unit dose blister package |
EP2790511B1 (en) | 2011-12-16 | 2016-09-14 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
USD828182S1 (en) * | 2012-02-06 | 2018-09-11 | Johnson & Johnson Consumer Inc. | Blister package |
CN104302761A (en) | 2012-03-16 | 2015-01-21 | 生育创新有限公司 | Processing of sperm cells |
AR092031A1 (en) | 2012-07-26 | 2015-03-18 | Merck Sharp & Dohme | INHIBITORS OF THE EXTERNAL RENAL MEDULAR POTASSIUM CHANNEL |
EP2925322B1 (en) | 2012-11-29 | 2018-10-24 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US9573961B2 (en) | 2012-12-19 | 2017-02-21 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
EP2956142B1 (en) | 2013-02-18 | 2017-09-20 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US9765074B2 (en) | 2013-03-15 | 2017-09-19 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US9751881B2 (en) | 2013-07-31 | 2017-09-05 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US9682012B2 (en) * | 2014-11-26 | 2017-06-20 | Mylan, Inc. | Container for storage of a medicament |
CN107427408A (en) | 2015-01-21 | 2017-12-01 | 迈兰公司 | Drug packages and dosage system |
JP6040295B1 (en) * | 2015-08-04 | 2016-12-07 | Ckd株式会社 | Blister sheet and blister packaging machine |
Family Cites Families (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2125318A (en) | 1937-09-20 | 1938-08-02 | Ivers Lee Co | Powder dispensing unit |
US3695417A (en) | 1970-08-17 | 1972-10-03 | Goodyear Tire & Rubber | Package with transparent window |
US3780856A (en) | 1971-07-26 | 1973-12-25 | Medi Dose Inc | Medicinal dispensing device |
US3924746A (en) | 1972-07-12 | 1975-12-09 | Paco Packaging | Childproof package |
US3835995A (en) | 1972-07-12 | 1974-09-17 | Paco Packaging | Tamperproof package |
US3809220A (en) | 1972-07-24 | 1974-05-07 | Becton Dickinson Co | Child safety package |
US3893578A (en) | 1974-04-08 | 1975-07-08 | Southwest Res Inst | System for injecting particulate material into the combustion chamber of a repetitive combustion coating apparatus |
US4011949A (en) | 1975-06-18 | 1977-03-15 | The Lehigh Press, Inc. | Package construction for opening only by a predetermined procedure |
US4243144A (en) | 1979-04-09 | 1981-01-06 | Sterling Drug Inc. | Bend and peel blister strip package |
US4294361A (en) | 1979-04-09 | 1981-10-13 | Sterling Drug, Inc. | Push and peel blister strip packages |
DE2916564A1 (en) * | 1979-04-24 | 1980-11-06 | Hahn Carl Dr Gmbh | TAMPON PACK |
US4316541A (en) | 1980-03-31 | 1982-02-23 | Medi-Dose, Inc. | Moisture impervious cover sheet for unit dose packaging |
US4332327A (en) | 1980-05-06 | 1982-06-01 | The Procter & Gamble Company | Accurately placed stress concentrating aperture in flexible packages |
US4398635A (en) | 1981-07-30 | 1983-08-16 | American Can Company | Child-proof medication package |
US4398634A (en) | 1981-11-12 | 1983-08-16 | Wrapade Machine Company, Inc. | Child-proof package system |
US4650079A (en) | 1983-02-08 | 1987-03-17 | Kazuhiro Itoh | Easy-to-open synthetic resin bag and apparatus for the manufacture thereof |
US4537312A (en) | 1983-05-19 | 1985-08-27 | Intini Thomas D | Child-resistant tamper-evident package |
US4506789A (en) | 1983-06-30 | 1985-03-26 | Packaging Coordinators, Inc. | Child resistant package |
US4720011A (en) | 1986-09-30 | 1988-01-19 | E. I. Du Pont De Nemours And Company | Package having tearstrip opener |
US4762230A (en) | 1986-10-08 | 1988-08-09 | Warner-Lambert Company | Tear oriented package |
US4781294A (en) | 1986-10-08 | 1988-11-01 | Warner-Lambert Company | Tear oriented package |
US4724982A (en) | 1986-12-18 | 1988-02-16 | Sanford Redmond | Asymmetric stress concentrator for a dispenser package |
US5088603A (en) | 1987-04-21 | 1992-02-18 | Sharp Packaging | Tear-opening caplet blister foil package |
NL8701700A (en) | 1987-07-17 | 1989-02-16 | Heijenga S Management B V | HOLDER FOR A LIQUID OR PASTIC PRODUCT. |
US4890744A (en) | 1988-10-28 | 1990-01-02 | W. A. Lane, Inc. | Easy open product pouch |
US4923063A (en) | 1988-11-03 | 1990-05-08 | Webcraft Technologies, Inc. | Sample packet for creams and method of manufacture |
CH678713A5 (en) | 1989-05-18 | 1991-10-31 | Renata Ag | |
US4981213A (en) | 1989-12-20 | 1991-01-01 | G. D. Searle & Co. | Package having an improved opening feature |
NL9000640A (en) | 1990-03-20 | 1991-10-16 | Sara Lee De Nv | PACKAGING DESIGNED FOR THE RECEPTION AND DELIVERY OF PRODUCTS SUCH AS TABLETS. |
US5046618A (en) | 1990-11-19 | 1991-09-10 | R. P. Scherer Corporation | Child-resistant blister pack |
US5172812A (en) | 1992-01-23 | 1992-12-22 | Rexham Corporation | Child-resistant paperboard blister package and method of making the same |
US5339960A (en) | 1992-08-24 | 1994-08-23 | Eli Lilly And Company | Child resistant package and method for making same |
EP0662918A1 (en) | 1992-09-30 | 1995-07-19 | R.P. Scherer Corporation | Stepped-edge blister pack and use of steps |
US5310060A (en) | 1992-10-13 | 1994-05-10 | G. D. Searle & Co. | Tamper-evident, child-resistant blister packages for medicaments and non-medicaments |
US5242055A (en) | 1992-11-27 | 1993-09-07 | Udl Laboratories, Inc. | Packaging system for medication |
CA2163617C (en) | 1993-05-28 | 1998-12-08 | Peter Worthington Hamilton | Dual chamber - child-resistant blister package |
US5325968A (en) | 1993-07-14 | 1994-07-05 | Mcneil-Ppc, Inc. | Package for holding tablets |
DE9313193U1 (en) | 1993-07-26 | 1993-10-28 | Klocke Verpackungs Service | Packaging for lumpy goods |
US5443154A (en) | 1993-09-27 | 1995-08-22 | Oscar Mayer Foods Corporation | Easy separating package and method |
US5472093A (en) | 1993-09-30 | 1995-12-05 | Becton Dickinson And Company | Tandem package and system for making same |
US5938032A (en) | 1993-09-30 | 1999-08-17 | Ivers-Lee Corporation | Tandem package with pinhole |
DE69529657T2 (en) | 1994-03-22 | 2003-12-18 | Sanyo Electric Co | A STRIP OF BAGS FOR MEDICINAL PRODUCTS |
US5551567A (en) | 1994-04-29 | 1996-09-03 | Mcneil-Ppc, Inc. | Blister package containing gripping means |
ES2150572T3 (en) | 1994-07-26 | 2000-12-01 | Upjohn Co | CONTAINER CONVERTIBLE PACKAGING UNACCESSIBLE FOR CHILDREN. |
US5469968A (en) | 1994-09-22 | 1995-11-28 | Reynolds Metals Company | Peel-peel-push childproof packaging structure |
US5529188A (en) | 1994-09-28 | 1996-06-25 | Becton Dickinson And Company | Child resistant carded type blister folder |
US5511665A (en) | 1994-10-31 | 1996-04-30 | G. D. Searle & Co. | Child-resistant package |
FR2728456B1 (en) | 1994-12-23 | 1997-03-21 | Instr Medecine Veterinaire | MACHINE FOR MANUFACTURING READY-TO-USE DOSES, ANIMAL SEED AND DOSE OF SEED MADE BY THIS MACHINE |
US5785180A (en) | 1995-06-22 | 1998-07-28 | G. D. Searle & Co. | Child-resistant package |
US5775505A (en) | 1996-02-27 | 1998-07-07 | Vasquez; William M. | Blister card package |
US5878888A (en) | 1996-10-10 | 1999-03-09 | Mcneil-Ppc, Inc. | Push through and peel child resistant blister package |
US5862915A (en) | 1996-10-10 | 1999-01-26 | Mcneil-Ppc, Inc. | Cavity assist easy to open child resistant blister package |
US5894930A (en) | 1996-10-10 | 1999-04-20 | Mcneil-Ppc, Inc. | Directional push and peel easy to open child resistant blister package |
EP0844193A1 (en) | 1996-11-25 | 1998-05-27 | Rayovac Corporation | Package |
US5878887A (en) | 1997-07-16 | 1999-03-09 | The West Company, Incorporated | Child-resistant blister package |
US5944191A (en) | 1998-01-14 | 1999-08-31 | Fuisz Technologies Ltd. | Peelable entry-resistant package |
US6036016A (en) * | 1998-04-20 | 2000-03-14 | Pinnacle Intellectual Property Services, Inc. | Blister package with easy tear blister |
US6199698B1 (en) * | 1999-12-03 | 2001-03-13 | Alusuisse Technology & Management, Ltd. | Pharmaceutical packaging with separation means |
-
2000
- 2000-07-06 US US09/611,404 patent/US6352158B1/en not_active Expired - Lifetime
-
2001
- 2001-05-08 AT AT01937249T patent/ATE263720T1/en not_active IP Right Cessation
- 2001-05-08 CA CA002413034A patent/CA2413034C/en not_active Expired - Lifetime
- 2001-05-08 AU AU2001263002A patent/AU2001263002B2/en not_active Expired
- 2001-05-08 DE DE60102699T patent/DE60102699T2/en not_active Expired - Lifetime
- 2001-05-08 TR TR2004/00876T patent/TR200400876T4/en unknown
- 2001-05-08 NZ NZ522950A patent/NZ522950A/en not_active IP Right Cessation
- 2001-05-08 EP EP01937249A patent/EP1301415B1/en not_active Expired - Lifetime
- 2001-05-08 AU AU6300201A patent/AU6300201A/en active Pending
- 2001-05-08 PT PT01937249T patent/PT1301415E/en unknown
- 2001-05-08 JP JP2002508991A patent/JP3693996B2/en not_active Expired - Lifetime
- 2001-05-08 WO PCT/US2001/014802 patent/WO2002004314A1/en active IP Right Grant
- 2001-05-08 MX MXPA02011884A patent/MXPA02011884A/en active IP Right Grant
- 2001-05-08 DK DK01937249T patent/DK1301415T3/en active
- 2001-05-08 ES ES01937249T patent/ES2214421T3/en not_active Expired - Lifetime
-
2002
- 2002-11-27 ZA ZA200209646A patent/ZA200209646B/en unknown
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