AU2001259786A1 - Bidirectional flow centrifugal microfluidic devices - Google Patents

Bidirectional flow centrifugal microfluidic devices

Info

Publication number
AU2001259786A1
AU2001259786A1 AU2001259786A AU5978601A AU2001259786A1 AU 2001259786 A1 AU2001259786 A1 AU 2001259786A1 AU 2001259786 A AU2001259786 A AU 2001259786A AU 5978601 A AU5978601 A AU 5978601A AU 2001259786 A1 AU2001259786 A1 AU 2001259786A1
Authority
AU
Australia
Prior art keywords
microfluidic devices
bidirectional flow
flow centrifugal
centrifugal microfluidic
based assays
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001259786A
Inventor
Bruce Carvalho
Greg Kellogg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tecan Boston
Original Assignee
Tecan Boston
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tecan Boston filed Critical Tecan Boston
Publication of AU2001259786A1 publication Critical patent/AU2001259786A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40Static mixers
    • B01F25/42Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/433Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
    • B01F25/4331Mixers with bended, curved, coiled, wounded mixing tubes or comprising elements for bending the flow
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30Micromixers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71Feed mechanisms
    • B01F35/712Feed mechanisms for feeding fluids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71Feed mechanisms
    • B01F35/717Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/71725Feed mechanisms characterised by the means for feeding the components to the mixer using centrifugal forces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71Feed mechanisms
    • B01F35/717Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/71805Feed mechanisms characterised by the means for feeding the components to the mixer using valves, gates, orifices or openings
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03Cuvette constructions
    • G01N21/07Centrifugal type cuvettes
    • AHUMAN NECESSITIES
    • A63SPORTS; GAMES; AMUSEMENTS
    • A63BAPPARATUS FOR PHYSICAL TRAINING, GYMNASTICS, SWIMMING, CLIMBING, OR FENCING; BALL GAMES; TRAINING EQUIPMENT
    • A63B63/00Targets or goals for ball games
    • A63B63/08Targets or goals for ball games with substantially horizontal opening for ball, e.g. for basketball
    • A63B63/083Targets or goals for ball games with substantially horizontal opening for ball, e.g. for basketball for basketball
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0605Metering of fluids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0803Disc shape
    • B01L2300/0806Standardised forms, e.g. compact disc [CD] format
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867Multiple inlets and one sample wells, e.g. mixing, dilution
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0874Three dimensional network
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/10Means to control humidity and/or other gases
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/18Means for temperature control
    • B01L2300/1805Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406Moving fluids with specific forces or mechanical means specific forces capillary forces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409Moving fluids with specific forces or mechanical means specific forces centrifugal forces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/06Valves, specific forms thereof
    • B01L2400/0677Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/06Valves, specific forms thereof
    • B01L2400/0688Valves, specific forms thereof surface tension valves, capillary stop, capillary break
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/08Regulating or influencing the flow resistance
    • B01L2400/084Passive control of flow resistance
    • B01L2400/088Passive control of flow resistance by specific surface properties
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502723Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by venting arrangements
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00Heating or cooling apparatus; Heat insulating devices
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00Heating or cooling apparatus; Heat insulating devices
    • B01L7/52Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B01L7/525Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465Separating and mixing arrangements
    • G01N2035/00495Centrifuges
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465Separating and mixing arrangements
    • G01N2035/00495Centrifuges
    • G01N2035/00504Centrifuges combined with carousels
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465Separating and mixing arrangements
    • G01N2035/00514Stationary mixing elements
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465Separating and mixing arrangements
    • G01N2035/00524Mixing by agitating sample carrier
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N35/00069Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides whereby the sample substrate is of the bio-disk type, i.e. having the format of an optical disk
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/11Automated chemical analysis
    • Y10T436/111666Utilizing a centrifuge or compartmented rotor

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pathology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Optical Measuring Cells (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Inspection Of Paper Currency And Valuable Securities (AREA)

Abstract

This invention provides methods and apparatus for performing microanalytic analyses and procedures, particularly miniaturized cell based assays. These methods are useful for performing a variety of cell-based assays, including drug candidate screening, life sciences research, and clinical and molecular diagnostics.
AU2001259786A 2000-05-15 2001-05-15 Bidirectional flow centrifugal microfluidic devices Abandoned AU2001259786A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20426400P 2000-05-15 2000-05-15
US60204264 2000-05-15
PCT/US2001/015824 WO2001087487A2 (en) 2000-05-15 2001-05-15 Bidirectional flow centrifugal microfluidic devices

Publications (1)

Publication Number Publication Date
AU2001259786A1 true AU2001259786A1 (en) 2001-11-26

Family

ID=22757246

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2001259786A Abandoned AU2001259786A1 (en) 2000-05-15 2001-05-15 Bidirectional flow centrifugal microfluidic devices
AU2001259785A Abandoned AU2001259785A1 (en) 2000-05-15 2001-05-15 Microfluidics devices and methods for performing cell based assays

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2001259785A Abandoned AU2001259785A1 (en) 2000-05-15 2001-05-15 Microfluidics devices and methods for performing cell based assays

Country Status (7)

Country Link
US (3) US6527432B2 (en)
EP (2) EP1284818B1 (en)
JP (2) JP2003533681A (en)
AT (1) ATE345868T1 (en)
AU (2) AU2001259786A1 (en)
DE (1) DE60124699T2 (en)
WO (2) WO2001087486A2 (en)

Families Citing this family (318)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050069923A1 (en) * 1996-07-08 2005-03-31 Mullis Kary Banks Dual bead assays using cleavable spacers and/or ligation to improve specificity and sensitivity including related methods and apparatus
US6248542B1 (en) * 1997-12-09 2001-06-19 Massachusetts Institute Of Technology Optoelectronic sensor
EP1230544B1 (en) * 1999-06-18 2004-07-28 Gamera Bioscience Corporation Devices and methods for the performance of miniaturized homogeneous assays
CA2721172C (en) * 1999-06-28 2012-04-10 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US20020151078A1 (en) * 2000-05-15 2002-10-17 Kellogg Gregory J. Microfluidics devices and methods for high throughput screening
US6720187B2 (en) * 2000-06-28 2004-04-13 3M Innovative Properties Company Multi-format sample processing devices
US6734401B2 (en) * 2000-06-28 2004-05-11 3M Innovative Properties Company Enhanced sample processing devices, systems and methods
US20030118486A1 (en) * 2000-07-03 2003-06-26 Xeotron Corporation Fluidic methods and devices for parallel chemical reactions
EP1410044A2 (en) * 2000-11-08 2004-04-21 Burstein Technologies, Inc. Interactive system for analyzing biological samples and processing related information and the use thereof
AU2002241602A1 (en) * 2000-11-16 2002-06-11 Burstein Technologies, Inc. Methods and apparatus for detecting and quantifying lymphocytes with optical biodiscs
WO2002040874A1 (en) * 2000-11-16 2002-05-23 California Institute Of Technology Apparatus and methods for conducting assays and high throughput screening
US7026131B2 (en) * 2000-11-17 2006-04-11 Nagaoka & Co., Ltd. Methods and apparatus for blood typing with optical bio-discs
US7087203B2 (en) 2000-11-17 2006-08-08 Nagaoka & Co., Ltd. Methods and apparatus for blood typing with optical bio-disc
WO2002042780A2 (en) * 2000-11-22 2002-05-30 Burstein Technologies, Inc. Apparatus and methods for separating agglutinants and disperse particles
WO2002043866A2 (en) * 2000-12-01 2002-06-06 Burstein Technologies, Inc. Apparatus and methods for separating components of particulate suspension
EP1410026A2 (en) * 2000-12-08 2004-04-21 Burstein Technologies, Inc. Methods for detecting analytes using optical discs and optical disc readers
US7054258B2 (en) 2000-12-08 2006-05-30 Nagaoka & Co., Ltd. Optical disc assemblies for performing assays
WO2002046721A2 (en) 2000-12-08 2002-06-13 Burstein Technologies, Inc. Optical discs for measuring analytes
US6760298B2 (en) * 2000-12-08 2004-07-06 Nagaoka & Co., Ltd. Multiple data layer optical discs for detecting analytes
US7091034B2 (en) 2000-12-15 2006-08-15 Burstein Technologies, Inc. Detection system for disk-based laboratory and improved optical bio-disc including same
US8216797B2 (en) * 2001-02-07 2012-07-10 Massachusetts Institute Of Technology Pathogen detection biosensor
US7422860B2 (en) 2001-02-07 2008-09-09 Massachusetts Institute Of Technology Optoelectronic detection system
DE60216051T2 (en) * 2001-02-07 2007-06-28 Massachusetts Institute Of Technology, Cambridge OPTOELECTRONIC SURVEY SYSTEM
US7759067B2 (en) 2001-03-19 2010-07-20 Gyros Patent Ab Method for determining the amount of an analyte with a disc-shaped microfluidic device
US7429354B2 (en) 2001-03-19 2008-09-30 Gyros Patent Ab Structural units that define fluidic functions
WO2003087827A2 (en) * 2001-04-11 2003-10-23 Burstein Technologies, Inc. Multi-parameter assays including analysis discs and methods relating thereto
US20030118804A1 (en) * 2001-05-02 2003-06-26 3M Innovative Properties Company Sample processing device with resealable process chamber
AU2002368023A1 (en) * 2001-05-16 2004-03-04 Burstein Technologies, Inc. Variable sampling for rendering pixelization of analysis results in optical bio-disc assembly
US6837927B2 (en) * 2001-06-08 2005-01-04 Syrrx, Inc. Microvolume device employing fluid movement by centrifugal force
US6916372B2 (en) * 2001-06-08 2005-07-12 Syrrx, Inc. Microvolume device employing fluid movement by centrifugal force
US6780240B2 (en) * 2001-06-08 2004-08-24 Syrrx, Inc. Method for causing fluid movement by centrifugal force
US6761766B2 (en) * 2001-06-08 2004-07-13 Syrrx, Inc. Method for parallel delivery and mixing of fluids by rotating a microfluidic device
US7014705B2 (en) * 2001-06-08 2006-03-21 Takeda San Diego, Inc. Microfluidic device with diffusion between adjacent lumens
US6837926B2 (en) * 2001-06-08 2005-01-04 Syrrx, Inc. Device for detecting precipitate formation in microvolumes
US6811609B2 (en) * 2001-06-08 2004-11-02 Syrrx, Inc. Microvolume device employing fluid movement by centrifugal force in different directions
US6797056B2 (en) * 2001-06-08 2004-09-28 Syrrx, Inc. Microfluidic method employing delivery of plural different fluids to same lumen
US6719840B2 (en) * 2001-06-08 2004-04-13 Syrrx, Inc. In situ crystal growth and crystallization
US7141416B2 (en) * 2001-07-12 2006-11-28 Burstein Technologies, Inc. Multi-purpose optical analysis optical bio-disc for conducting assays and various reporting agents for use therewith
US20030230383A1 (en) * 2001-07-24 2003-12-18 Glenn Sasaki Method and apparatus for bonded fluidic circuit for optical bio-disc
US20040226348A1 (en) * 2001-07-24 2004-11-18 Phillip Bruce Magnetic assisted detection of magnetic beads using optical disc drives
WO2003018198A1 (en) 2001-08-28 2003-03-06 Gyros Ab Retaining microfluidic microcavity and other microfluidic structures
US6791677B2 (en) * 2001-08-28 2004-09-14 Tosoh Corporation Information measuring apparatus using a fine channel device
US6919058B2 (en) 2001-08-28 2005-07-19 Gyros Ab Retaining microfluidic microcavity and other microfluidic structures
US20030129665A1 (en) * 2001-08-30 2003-07-10 Selvan Gowri Pyapali Methods for qualitative and quantitative analysis of cells and related optical bio-disc systems
US20030143637A1 (en) * 2001-08-31 2003-07-31 Selvan Gowri Pyapali Capture layer assemblies for cellular assays including related optical analysis discs and methods
WO2003023354A2 (en) * 2001-09-07 2003-03-20 Burstein Technologies, Inc. Optical bio-disc systems for nuclear morphology based identification
US7189368B2 (en) 2001-09-17 2007-03-13 Gyros Patent Ab Functional unit enabling controlled flow in a microfluidic device
US20030082632A1 (en) * 2001-10-25 2003-05-01 Cytoprint, Inc. Assay method and apparatus
US20030138969A1 (en) * 2002-01-24 2003-07-24 Jakobsen Mogens Havsteen Closed substrate platforms suitable for analysis of biomolecules
US7157049B2 (en) * 2001-11-20 2007-01-02 Nagaoka & Co., Ltd. Optical bio-discs and fluidic circuits for analysis of cells and methods relating thereto
WO2003054513A2 (en) * 2001-12-20 2003-07-03 Radius Biosciences Centrifugal array processing device
JP3952019B2 (en) * 2001-12-28 2007-08-01 株式会社日立ハイテクノロジーズ Extraction apparatus, chemical analysis apparatus, and chemical analysis method
US6889468B2 (en) * 2001-12-28 2005-05-10 3M Innovative Properties Company Modular systems and methods for using sample processing devices
US6773677B2 (en) * 2002-01-09 2004-08-10 Caliper Life Sciences, Inc. Slide cassette for fluidic injection
US20050003459A1 (en) * 2002-01-30 2005-01-06 Krutzik Siegfried Richard Multi-purpose optical analysis disc for conducting assays and related methods for attaching capture agents
WO2003065355A2 (en) * 2002-01-31 2003-08-07 Burstein Technologies, Inc. Bio-safety features for optical analysis disc and disc system including same
WO2003064996A2 (en) * 2002-01-31 2003-08-07 Burstein Technologies, Inc. Bio-safe dispenser and optical analysis disc assembly
WO2003065354A2 (en) * 2002-01-31 2003-08-07 Burstein Technologies, Inc. Manufacturing processes for making optical analysis discs including successive patterning operations and optical discs thereby manufactured
US20040241381A1 (en) * 2002-01-31 2004-12-02 Chen Yihfar Microfluidic structures with circumferential grooves for bonding adhesives and related optical analysis discs
JP2003225083A (en) * 2002-02-05 2003-08-12 Sony Corp Disc-shaped culturing medium
WO2003085379A2 (en) * 2002-04-01 2003-10-16 Fluidigm Corporation Microfluidic particle-analysis systems
WO2003093802A1 (en) * 2002-04-30 2003-11-13 Gyros Ab Integrated microfluidic device (ea)
EP1500937B1 (en) * 2002-04-30 2017-06-28 ARKRAY, Inc. Analyzing article, analyzer and method of analyzing a sample using the analyzing article
US8361783B2 (en) * 2002-05-09 2013-01-29 Nanologix, Inc. Micromethod and device for the rapid detection, enumeration and identification of microorganisms
US8663909B2 (en) * 2002-05-09 2014-03-04 Nanologix, Inc. Device for rapid detection and identification of single microorganisms without preliminary growth
US7781159B2 (en) * 2002-05-09 2010-08-24 Nanologix, Inc. Micromethod and device for rapid detection, enumeration and identification of entities
US20050106714A1 (en) * 2002-06-05 2005-05-19 Zarur Andrey J. Rotatable reactor systems and methods
US7083974B2 (en) 2002-07-12 2006-08-01 Applera Corporation Rotatable sample disk and method of loading a sample disk
US7198759B2 (en) * 2002-07-26 2007-04-03 Applera Corporation Microfluidic devices, methods, and systems
US7041258B2 (en) * 2002-07-26 2006-05-09 Applera Corporation Micro-channel design features that facilitate centripetal fluid transfer
US7790443B2 (en) * 2002-08-27 2010-09-07 Vanderbilt University Bioreactors with substance injection capacity
WO2004020342A2 (en) * 2002-08-27 2004-03-11 Vanderbilt University Capillary perfused bioreactors with multiple chambers
US7534601B2 (en) * 2002-08-27 2009-05-19 Vanderbilt University Capillary perfused bioreactors with multiple chambers
US7094345B2 (en) * 2002-09-09 2006-08-22 Cytonome, Inc. Implementation of microfluidic components, including molecular fractionation devices, in a microfluidic system
CA2508475C (en) * 2002-12-04 2011-08-30 Spinx, Inc. Devices and methods for programmable microscale manipulation of fluids
US7125711B2 (en) * 2002-12-19 2006-10-24 Bayer Healthcare Llc Method and apparatus for splitting of specimens into multiple channels of a microfluidic device
US7648678B2 (en) 2002-12-20 2010-01-19 Dako Denmark A/S Method and system for pretreatment of tissue slides
US7476361B2 (en) * 2002-12-24 2009-01-13 Tecan Trading Ag Microfluidics devices and methods of diluting samples and reagents
US7332129B2 (en) * 2003-01-09 2008-02-19 3M Innovative Properties Company Sample processing device having process chambers with bypass slots
JP4519124B2 (en) 2003-01-30 2010-08-04 ユィロス・パテント・アクチボラグ Wall inside the microfluidic device
SE0300823D0 (en) 2003-03-23 2003-03-23 Gyros Ab Preloaded Microscale Devices
SE0300822D0 (en) 2003-03-23 2003-03-23 Gyros Ab A collection of Micro Scale Devices
JP3888632B2 (en) * 2003-03-26 2007-03-07 靖浩 堀池 Micromixer, sample analysis kit and manufacturing method thereof
WO2004087281A2 (en) * 2003-03-31 2004-10-14 Cytonome, Inc. Implementation of microfluidic components, including molecular fractionation devices, in a microfluidic system
US20040241049A1 (en) * 2003-04-04 2004-12-02 Carvalho Bruce L. Elastomeric tools for the fabrication of elastomeric devices and uses thereof
US20050037484A1 (en) * 2003-04-23 2005-02-17 Norbert Staimer Optical bio-discs including spiral fluidic circuits for performing assays
EP1618206A4 (en) * 2003-04-30 2006-11-29 Biovitesse Apparatus and method for detecting live cells with an integrated filter and growth detection device
CA2524496A1 (en) * 2003-05-06 2004-11-25 Bellbrook Labs, Llc Three dimensional cell cultures in a microscale fluid handling system
US7225937B2 (en) * 2003-05-13 2007-06-05 Schroeder Michael D Package system
US7435381B2 (en) * 2003-05-29 2008-10-14 Siemens Healthcare Diagnostics Inc. Packaging of microfluidic devices
US7160025B2 (en) * 2003-06-11 2007-01-09 Agency For Science, Technology And Research Micromixer apparatus and methods of using same
US7390464B2 (en) * 2003-06-19 2008-06-24 Burstein Technologies, Inc. Fluidic circuits for sample preparation including bio-discs and methods relating thereto
EP1656203A2 (en) * 2003-06-19 2006-05-17 Nagaoka & Co., Ltd. Fluidic circuits for sample preparation including bio-discs and methods relating thereto
US20080257754A1 (en) * 2003-06-27 2008-10-23 Pugia Michael J Method and apparatus for entry of specimens into a microfluidic device
WO2005001429A2 (en) * 2003-06-27 2005-01-06 Nagaoka & Co., Ltd. Fluidic circuits, methods and apparatus for use of whole blood samples in colorimetric assays
US20040265171A1 (en) * 2003-06-27 2004-12-30 Pugia Michael J. Method for uniform application of fluid into a reactive reagent area
US20040265172A1 (en) * 2003-06-27 2004-12-30 Pugia Michael J. Method and apparatus for entry and storage of specimens into a microfluidic device
US7238269B2 (en) * 2003-07-01 2007-07-03 3M Innovative Properties Company Sample processing device with unvented channel
US20070274863A1 (en) * 2003-07-25 2007-11-29 Horacio Kido Fluidic circuits for sample preparation including bio-discs and methods relating thereto
US7524623B2 (en) * 2003-07-28 2009-04-28 Nanologix, Inc. Method and device for rapid detection of microorganisms by changing the shape of micro-colonies
JPWO2005012916A1 (en) * 2003-08-05 2006-09-21 太陽誘電株式会社 Sample analyzer and disk-shaped sample analysis medium
US7347617B2 (en) * 2003-08-19 2008-03-25 Siemens Healthcare Diagnostics Inc. Mixing in microfluidic devices
US7582472B2 (en) * 2003-08-26 2009-09-01 Smith Kenneth E Apparatus and method for liquid sample testing
JP3959436B2 (en) * 2003-08-29 2007-08-15 独立行政法人物質・材料研究機構 Flow fluctuation structure and micromixer
CN1864058B (en) * 2003-10-03 2012-07-18 独立行政法人物质·材料研究机构 Chip using method and test chip
US7776272B2 (en) * 2003-10-03 2010-08-17 Gyros Patent Ab Liquid router
US7147362B2 (en) * 2003-10-15 2006-12-12 Agilent Technologies, Inc. Method of mixing by intermittent centrifugal force
US20050130177A1 (en) * 2003-12-12 2005-06-16 3M Innovative Properties Company Variable valve apparatus and methods
US7837947B2 (en) * 2003-12-12 2010-11-23 3M Innovative Properties Company Sample mixing on a microfluidic device
US7322254B2 (en) * 2003-12-12 2008-01-29 3M Innovative Properties Company Variable valve apparatus and methods
JP4632400B2 (en) * 2003-12-16 2011-02-16 キヤノン株式会社 Cell culture substrate, method for producing the same, and cell screening method using the same
US20050142571A1 (en) * 2003-12-24 2005-06-30 3M Innovative Properties Company Methods for nucleic acid isolation and kits using solid phase material
US7939249B2 (en) * 2003-12-24 2011-05-10 3M Innovative Properties Company Methods for nucleic acid isolation and kits using a microfluidic device and concentration step
US20050142570A1 (en) * 2003-12-24 2005-06-30 3M Innovative Properties Company Methods for nucleic acid isolation and kits using a microfluidic device and sedimenting reagent
US7407799B2 (en) * 2004-01-16 2008-08-05 California Institute Of Technology Microfluidic chemostat
GB0401045D0 (en) * 2004-01-17 2004-02-18 Univ Sheffield Fluid-contactor
US8592219B2 (en) 2005-01-17 2013-11-26 Gyros Patent Ab Protecting agent
SE0400181D0 (en) 2004-01-29 2004-01-29 Gyros Ab Segmented porous and preloaded microscale devices
JP2005257337A (en) * 2004-03-09 2005-09-22 Brother Ind Ltd Inspection object receiver, inspection device, and inspection method
US7432106B2 (en) * 2004-03-24 2008-10-07 Applied Biosystems Inc. Liquid processing device including gas trap, and system and method
JP2005295877A (en) * 2004-04-09 2005-10-27 Taiyo Yuden Co Ltd Method for analyzing nucleic acid, analyzer and disk for analysis
US7491363B2 (en) * 2004-07-15 2009-02-17 Applied Biosystems, Llc. Fluid processing device
EP1794282A4 (en) * 2004-09-20 2011-03-23 Boston Microfluidics Microfluidic device for detecting soluble molecules
DE102004046396A1 (en) * 2004-09-24 2006-04-13 Land Baden-Württemberg, vertreten durch das Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberg, vertreten durch den Minister A particle sedimentation apparatus and method for performing a particle sedimentation
EP1795898B1 (en) * 2004-09-30 2014-03-12 ARKRAY, Inc. Analyzer
JP4368383B2 (en) * 2004-10-01 2009-11-18 株式会社アドバンス Solid-liquid separation structure
JP2006110523A (en) * 2004-10-18 2006-04-27 Hitachi Software Eng Co Ltd Chemical reaction device
JP4458253B2 (en) * 2004-10-28 2010-04-28 有限会社バイオデバイステクノロジー Microchip for specimen sample
CN101073003B (en) * 2004-12-08 2011-07-06 松下电器产业株式会社 Plate for biological sample analysis
JP2006177837A (en) * 2004-12-24 2006-07-06 Hitachi Ltd Luminescence detection apparatus
JP5006800B2 (en) 2005-01-17 2012-08-22 ユィロス・パテント・アクチボラグ Method for detecting at least divalent analyte using two affinity reactants
JP4422623B2 (en) * 2005-01-17 2010-02-24 株式会社日立ハイテクノロジーズ Chemical analysis apparatus and chemical analysis cartridge
KR100668323B1 (en) * 2005-01-19 2007-01-12 삼성전자주식회사 Portable biochip scanner using surface plasmon resonance
JP4689665B2 (en) * 2005-04-04 2011-05-25 パナソニック株式会社 Liquid homogenizer and analyzer using the same
CA2517299A1 (en) * 2005-08-26 2007-02-26 Chromedx Inc. Hollow needle assembly
US20100245803A1 (en) * 2005-04-12 2010-09-30 Chromedx Inc. Blood sample holder for spectroscopic analysis
US8206650B2 (en) * 2005-04-12 2012-06-26 Chromedx Inc. Joint-diagnostic spectroscopic and biosensor meter
US7740804B2 (en) * 2005-04-12 2010-06-22 Chromedx Inc. Spectroscopic sample holder
CA2507323A1 (en) * 2005-05-13 2006-11-13 Chromedx Inc. Diagnostic whole blood and plasma apparatus
EP1874469A4 (en) 2005-04-14 2014-02-26 Gyros Patent Ab A microfluidic device with finger valves
WO2006110097A1 (en) * 2005-04-14 2006-10-19 Gyros Patent Ab Separation structure
US20080286156A1 (en) * 2005-04-14 2008-11-20 Gyros Patent Ab Upward Microconduits
US20090111190A1 (en) * 2005-04-14 2009-04-30 Gyros Patent Ab Meander
JP4927818B2 (en) * 2005-04-14 2012-05-09 ギロス・パテント・エービー Meander
EP1874674B1 (en) * 2005-04-14 2013-06-05 Gyros Patent Ab Liquid plugs
MX340077B (en) 2005-05-09 2016-06-24 Theranos Inc Point-of-care fluidic systems and uses thereof.
US20060263265A1 (en) * 2005-05-23 2006-11-23 Der-Ren Kang Blood micro-separator
JP3805352B1 (en) * 2005-05-25 2006-08-02 株式会社エンプラス Fluid handling device and fluid handling unit used therefor
US20060281192A1 (en) * 2005-06-13 2006-12-14 Harding Philip H Method for mixing fluids in microfluidic systems
US7935318B2 (en) * 2005-06-13 2011-05-03 Hewlett-Packard Development Company, L.P. Microfluidic centrifugation systems
US7437914B2 (en) * 2005-06-28 2008-10-21 Hewlett-Packard Development Company, L.P. Microfluidic test systems with gas bubble reduction
US7763210B2 (en) 2005-07-05 2010-07-27 3M Innovative Properties Company Compliant microfluidic sample processing disks
US7323660B2 (en) * 2005-07-05 2008-01-29 3M Innovative Properties Company Modular sample processing apparatus kits and modules
US7754474B2 (en) * 2005-07-05 2010-07-13 3M Innovative Properties Company Sample processing device compression systems and methods
WO2007021919A1 (en) * 2005-08-12 2007-02-22 Clemson University Co-culture bioreactor system
WO2007035350A2 (en) * 2005-09-15 2007-03-29 University Of Utah Research Foundation Bioluminescence-based sensor with centrifugal separation and enhanced light collection
KR100733914B1 (en) 2005-09-22 2007-07-02 한국과학기술원 Microfluidic 3-dimensional cell culture system
US8449837B2 (en) * 2005-10-11 2013-05-28 The Johns Hopkins University Microfluidic device for high-throughput cellular gradient and dose response studies
WO2007044856A1 (en) * 2005-10-11 2007-04-19 The Johns Hopkins University Device and method for high-throughput stimulation, immunostaining, and visualization of single cells
JP4687413B2 (en) * 2005-11-16 2011-05-25 コニカミノルタエムジー株式会社 Method for mixing two or more liquids in a microchip and a micro total analysis system
US7927787B2 (en) 2006-06-28 2011-04-19 The Invention Science Fund I, Llc Methods and systems for analysis of nutraceutical associated components
US8297028B2 (en) 2006-06-14 2012-10-30 The Invention Science Fund I, Llc Individualized pharmaceutical selection and packaging
US8068991B2 (en) 2005-11-30 2011-11-29 The Invention Science Fund I, Llc Systems and methods for transmitting pathogen related information and responding
US7974856B2 (en) 2005-11-30 2011-07-05 The Invention Science Fund I, Llc Computational systems and methods related to nutraceuticals
US7827042B2 (en) 2005-11-30 2010-11-02 The Invention Science Fund I, Inc Methods and systems related to transmission of nutraceutical associated information
US10296720B2 (en) 2005-11-30 2019-05-21 Gearbox Llc Computational systems and methods related to nutraceuticals
US20080241935A1 (en) 2007-03-27 2008-10-02 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods for pathogen detection
US8000981B2 (en) 2005-11-30 2011-08-16 The Invention Science Fund I, Llc Methods and systems related to receiving nutraceutical associated information
US8340944B2 (en) 2005-11-30 2012-12-25 The Invention Science Fund I, Llc Computational and/or control systems and methods related to nutraceutical agent selection and dosing
DE102005057685A1 (en) * 2005-12-01 2007-06-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Inhaler and storage for a dry drug formulation and methods and use thereof
WO2007069940A1 (en) 2005-12-12 2007-06-21 Gyros Patent Ab Microfluidic assays and microfluidic devices
US20070134739A1 (en) * 2005-12-12 2007-06-14 Gyros Patent Ab Microfluidic assays and microfluidic devices
US7651869B2 (en) * 2006-03-14 2010-01-26 Research International, Inc. Optical assay apparatus and methods
JP4754394B2 (en) * 2006-04-14 2011-08-24 ローム株式会社 Microchip
JP4593517B2 (en) * 2006-05-15 2010-12-08 株式会社日立ハイテクノロジーズ Chemical analyzer
JP4597091B2 (en) * 2006-05-24 2010-12-15 株式会社日立ハイテクノロジーズ Biochemical analyzer and inspection cartridge used therefor
GB0614297D0 (en) * 2006-07-19 2006-08-30 Shaw Water Engineering Ltd Apparatus, system and method for detecting particles
WO2008016271A1 (en) * 2006-08-02 2008-02-07 Jae Chern Yoo Thin film chemical analysis apparatus and analysis method using the same
WO2008039207A1 (en) * 2006-09-27 2008-04-03 The Scripps Research Institute Biochemical applications of a microfluidic serial dilution circuit
US8012744B2 (en) * 2006-10-13 2011-09-06 Theranos, Inc. Reducing optical interference in a fluidic device
US8008034B2 (en) * 2006-10-13 2011-08-30 Theranos, Inc. Reducing optical interference in a fluidic device
WO2008060415A1 (en) * 2006-11-09 2008-05-22 The Board Of Trustees Of The University Of Illinois Photonic crystal sensors with integrated fluid containment structure
US20080131955A1 (en) * 2006-11-30 2008-06-05 Canon U.S. Life Sciences, Inc. Method of Separating Target DNA from Mixed DNA
AU2007336774A1 (en) 2006-12-22 2008-07-03 3M Innovative Properties Company Thermal transfer methods and structures for microfluidic systems
CN101568384B (en) * 2006-12-22 2013-05-01 3M创新有限公司 Enhanced sample processing devices, systems and methods
US8164828B2 (en) 2006-12-26 2012-04-24 Nsk Ltd. Observable centrifugal apparatus and observation apparatus
US8617903B2 (en) 2007-01-29 2013-12-31 The Invention Science Fund I, Llc Methods for allergen detection
US10001496B2 (en) 2007-01-29 2018-06-19 Gearbox, Llc Systems for allergen detection
KR101305976B1 (en) * 2007-02-12 2013-09-12 삼성전자주식회사 Centrifugal force based microfluidic device for serial dilution and microfluidic system comprising the same
WO2008106782A1 (en) * 2007-03-02 2008-09-12 Universite Laval Serial siphon valves for fluidic or microfluidic devices
US20100227338A1 (en) * 2007-03-22 2010-09-09 Nanologix, Inc. Method and Apparatus for Rapid Detection and Identification of Live Microorganisms Immobilized On Permeable Membrane by Antibodies
US9068216B2 (en) 2007-03-22 2015-06-30 Bret T. Barnhizer Methods and devices for rapid detection and identification of live microorganisms by aptamers and/or antibodies immobilized on permeable membranes
US20090215157A1 (en) * 2007-03-27 2009-08-27 Searete Llc Methods for pathogen detection
KR100858091B1 (en) * 2007-04-24 2008-09-10 삼성전자주식회사 Centrifugal force-based microfluidic device having sample distribution structure and microfluidic system including the microfluidic device
US20100129878A1 (en) * 2007-04-25 2010-05-27 Parthasarathy Ranjani V Methods for nucleic acid amplification
US20080277356A1 (en) * 2007-05-07 2008-11-13 Caliper Life Sciences, Inc. Microfluidic Device with a Filter
JP4911514B2 (en) * 2007-05-14 2012-04-04 独立行政法人産業技術総合研究所 Microchip, liquid dispensing method
JP4836272B2 (en) * 2007-05-15 2011-12-14 独立行政法人産業技術総合研究所 Liquid introduction device
KR101228308B1 (en) 2007-05-23 2013-01-31 삼성전자주식회사 Disk type microfluidic device using microfluidic chip and disk type microfluidic device using biomolecule microarray chip
KR101335726B1 (en) 2007-06-04 2013-12-04 삼성전자주식회사 Disk type microfluidic device for conducting immunoassey and biochemistry analysis simultaneously
KR20080107212A (en) * 2007-06-05 2008-12-10 삼성전자주식회사 Microfluidic apparatus with fluid container
IL184183A0 (en) * 2007-06-25 2007-10-31 Benjamin Alspector Bi directional transfer of an aliquot of fluid between compartments
KR101335727B1 (en) * 2007-08-22 2013-12-04 삼성전자주식회사 Centrifugal force-based disk type microfluidic device for blood chemistry analysis
DK2205968T3 (en) 2007-10-02 2014-02-17 Theranos Inc Modular POC (point of care) Devices and uses thereof
EP2209008B1 (en) * 2007-10-04 2016-12-21 Panasonic Healthcare Holdings Co., Ltd. Analysis device, and analysis apparatus and method using the same
TWI362491B (en) * 2007-11-02 2012-04-21 Ind Tech Res Inst Fluid analytical device and fluid analytical method thereof
US20090122637A1 (en) * 2007-11-14 2009-05-14 Jan Kruyer Sinusoidal mixing and shearing apparatus and associated methods
US20110097814A1 (en) * 2007-11-20 2011-04-28 Bommarito G Marco Detection devices and methods
CN101873885B (en) * 2007-11-22 2013-07-31 三星电子株式会社 Thin film valve device and its controlling apparatus
JP5174627B2 (en) * 2008-01-21 2013-04-03 パナソニック株式会社 Analysis equipment
US8486333B2 (en) * 2008-02-04 2013-07-16 Micropoint Biosciences, Inc. Centrifugal fluid analyzer rotor
WO2009108654A2 (en) * 2008-02-25 2009-09-03 Clemson University Differential pressure pump system
WO2009111461A2 (en) * 2008-03-04 2009-09-11 University Of Utah Research Foundation Microfluidic flow cell
US8632243B2 (en) * 2008-03-10 2014-01-21 The Hong Kong Polytechnic University Microfluidic mixing using continuous acceleration/deceleration methodology
US8735846B1 (en) 2008-03-14 2014-05-27 Advanced Technology Applications, Llc Electromagnetic biosensor
US7812318B1 (en) 2008-03-14 2010-10-12 Advanced Technology Applications, Llc Electromagnetic biosensor
CN102016596B (en) * 2008-03-27 2014-09-17 哈佛学院院长等 Paper-based microfluidic systems
KR20100009482A (en) * 2008-07-18 2010-01-27 삼성전자주식회사 Microfluidic device comprising a structure having air vent and valve, and method for transferring fluid by using the same
US8430558B1 (en) * 2008-09-05 2013-04-30 University Of Central Florida Research Foundation, Inc. Microfluidic mixer having channel width variation for enhanced fluid mixing
KR100997144B1 (en) * 2008-09-23 2010-11-30 삼성전자주식회사 Microfluidic device
US9289765B2 (en) * 2008-09-23 2016-03-22 Samsung Electronics Co., Ltd. Micro-fluidic device and sample testing apparatus using the same
US20100075863A1 (en) * 2008-09-25 2010-03-25 Northrop Grumman Systems Corporation Rotary array module for multiplexing spot-based optical readouts
GB2464300A (en) * 2008-10-10 2010-04-14 Univ Dublin City Microfluidic multiplexed cellular and molecular analysis device and method
KR101099495B1 (en) * 2008-10-14 2011-12-28 삼성전자주식회사 Centrifugal force-based microfluidic device, method of manufacturing the same and sample analysis method using the same
US7993583B2 (en) * 2008-10-29 2011-08-09 Lawrence Livermore National Security, Llc Passive microfluidic array card and reader
CN102317754B (en) 2008-12-19 2015-09-30 3M创新有限公司 For the treatment of the system and method for sample
EP2373974A1 (en) 2008-12-19 2011-10-12 3M Innovative Properties Company System and method for concentrating samples
US20120135446A1 (en) * 2009-03-04 2012-05-31 Maine Institute For Human Genetics & Health, Inc Microfluidic Device and Related Methods
KR20100101526A (en) * 2009-03-09 2010-09-17 삼성전자주식회사 Strobo thin film chemical analysis apparatus and assay method using the same
WO2010105185A1 (en) * 2009-03-13 2010-09-16 Terrasep, Llc Methods and apparatus for centrifugal liquid chromatography
WO2010106456A2 (en) * 2009-03-20 2010-09-23 International Business Machines Corporation Microorganism culture device and method of operation thereof
US9470609B2 (en) 2009-04-09 2016-10-18 Koninklijke Philips N. V. Preparation of thin layers of a fluid containing cells for analysis
US8383025B2 (en) * 2009-05-19 2013-02-26 Nanyang Technological University Method of manufacturing micro patterned device and device obtained by the method
US20100323434A1 (en) * 2009-06-19 2010-12-23 In Hong Yang Compartmentalized Nerve Culture System
US9120067B2 (en) * 2009-09-25 2015-09-01 Konica Minolta, Inc. Micro mixer and microfluidic chip
USD638951S1 (en) 2009-11-13 2011-05-31 3M Innovative Properties Company Sample processing disk cover
US8834792B2 (en) * 2009-11-13 2014-09-16 3M Innovative Properties Company Systems for processing sample processing devices
USD638550S1 (en) 2009-11-13 2011-05-24 3M Innovative Properties Company Sample processing disk cover
USD667561S1 (en) 2009-11-13 2012-09-18 3M Innovative Properties Company Sample processing disk cover
KR101422573B1 (en) * 2009-11-26 2014-07-25 삼성전자 주식회사 Centrifugal Micro-fluidic Device and Method to measure biological makers from liquid specimen
KR101722548B1 (en) * 2010-01-29 2017-04-03 삼성전자주식회사 Centrifugal Micro-fluidic Device and Method for detecting analytes from liquid specimen
US8428398B2 (en) * 2010-02-01 2013-04-23 Lawrence Livermore National Security, Llc Hand-held portable microarray reader for biodetection
JP2011155921A (en) * 2010-02-02 2011-08-18 Seiko Epson Corp Biochip, specimen reactor, and method for specimen reaction
CN102262051B (en) 2010-05-25 2015-04-08 香港城市大学 Optical sensing devices and methods for detecting samples using the same
US20130115606A1 (en) * 2010-07-07 2013-05-09 The University Of British Columbia System and method for microfluidic cell culture
US10087408B2 (en) 2010-07-07 2018-10-02 The University Of British Columbia System and method for microfluidic cell culture
US9795961B1 (en) 2010-07-08 2017-10-24 National Technology & Engineering Solutions Of Sandia, Llc Devices, systems, and methods for detecting nucleic acids using sedimentation
WO2012100235A2 (en) 2011-01-21 2012-07-26 Theranos, Inc. Systems and methods for sample use maximization
EP2684022B1 (en) * 2011-03-08 2017-09-27 Universite Laval Fluidic centripetal device
BR112013027990B1 (en) 2011-05-18 2020-11-03 Diasorin S.P.A. valve structure in a sample processing device and method for operating valves in a sample processing device
CN105170203B (en) 2011-05-18 2017-07-18 3M创新有限公司 Material system and method present in sample processing apparatus of the selected volume of detection
EP2709761B1 (en) 2011-05-18 2019-08-14 DiaSorin S.p.A. Systems and methods for volumetric metering on a sample processing device
USD672467S1 (en) 2011-05-18 2012-12-11 3M Innovative Properties Company Rotatable sample processing disk
EP2726842B1 (en) 2011-06-30 2016-03-16 3M Innovative Properties Company Systems and methods for detecting an analyte of interest in a sample using microstructured surfaces
US9470612B2 (en) 2011-06-30 2016-10-18 3M Innovative Properties Company Systems and methods for detecting an analyte of interest in a sample using filters and microstructured surfaces
US9442108B2 (en) 2011-08-30 2016-09-13 National Research Council Of Canada Centrifugally-enhanced capture method and device
US10384209B2 (en) 2011-09-15 2019-08-20 The Chinese University Of Hong Kong Microfluidic platform and method for controlling the same
US10265647B2 (en) 2011-12-07 2019-04-23 Royal Melbourne Institute Of Technology Centrifugal microfluidic device
WO2013112877A1 (en) 2012-01-25 2013-08-01 Tasso, Inc. Handheld device for drawing, collecting, and analyzing bodily fluid
US9244065B1 (en) 2012-03-16 2016-01-26 Sandia Corporation Systems, devices, and methods for agglutination assays using sedimentation
WO2013159116A1 (en) * 2012-04-20 2013-10-24 University Of Chicago Fluidic devices for biospecimen preservation
WO2013159117A1 (en) 2012-04-20 2013-10-24 SlipChip, LLC Fluidic devices and systems for sample preparation or autonomous analysis
EP2856110B1 (en) * 2012-06-05 2018-04-18 Siemens Healthcare Diagnostics Inc. System for serum sample quality determination
US8953168B2 (en) 2012-06-08 2015-02-10 City University Of Hong Kong Optical sensing devices and methods for detecting samples using the same
US9903001B1 (en) 2012-07-19 2018-02-27 National Technology & Engineering Solutions Of Sandia, Llc Quantitative detection of pathogens in centrifugal microfluidic disks
EP2874942B1 (en) * 2012-07-23 2018-09-05 Tasso, Inc. Methods and devices relating to open microfluidic channels
TWI475226B (en) * 2012-08-01 2015-03-01 Univ Feng Chia The apparatus and methodology to carry out biochemical testing on a centrifugal platform using flow splitting techniques
BR112015002561A2 (en) 2012-08-08 2018-05-22 Koninklijke Philips Nv system for separation of a heterogeneous analyte, and method for separation of a heterogeneous analyte.
WO2014058750A1 (en) 2012-10-08 2014-04-17 General Electric Company Microfluidic lal-reactive substances testing method and apparatus
DE102012220250A1 (en) * 2012-11-07 2014-05-08 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. FLUIDIKMODUL FOR A CENTRIFUGAL FILTRATION AND METHOD FOR FILTERING A SAMPLE
WO2014078785A1 (en) * 2012-11-19 2014-05-22 The General Hospital Corporation System and method for integrated multiplexed photometry module
US10215687B2 (en) 2012-11-19 2019-02-26 The General Hospital Corporation Method and system for integrated mutliplexed photometry module
US11366061B2 (en) 2013-01-24 2022-06-21 Grace Bio-Labs, Inc. Protein microarray assay imager
US9308508B2 (en) 2013-07-22 2016-04-12 Kianoosh Peyvan Sequential delivery device and method
US9803238B1 (en) 2013-11-26 2017-10-31 National Technology & Engineering Solutions Of Sandia, Llc Method and apparatus for purifying nucleic acids and performing polymerase chain reaction assays using an immiscible fluid
EP2952257A1 (en) 2014-06-06 2015-12-09 Roche Diagnostics GmbH Rotatable cartridge for processing and analyzing a biological sample
EP2952258A1 (en) * 2014-06-06 2015-12-09 Roche Diagnostics GmbH Rotatable cartridge for analyzing a biological sample
CN106489072B (en) * 2014-06-06 2019-05-14 豪夫迈·罗氏有限公司 The rotating cylinder for being used to analyze biological sample with measuring room
EP2957890A1 (en) * 2014-06-16 2015-12-23 Roche Diagnostics GmbH Cartridge with a rotatable lid
EP3174463B1 (en) 2014-08-01 2020-07-29 Tasso, Inc. Systems for gravity-enhanced microfluidic collection, handling and transferring of fluids
GB201415804D0 (en) * 2014-09-08 2014-10-22 Univ Singapore Assay Device
US9702871B1 (en) * 2014-11-18 2017-07-11 National Technology & Engineering Solutions Of Sandia, Llc System and method for detecting components of a mixture including a valving scheme for competition assays
KR101776245B1 (en) 2014-11-20 2017-09-11 울산과학기술원 Particle filtration device and method of particle filtration
US10166541B2 (en) * 2014-12-10 2019-01-01 The Regents Of The University Of California Centrifugal microfluidic platform for automated media exchange
EP3269445A4 (en) * 2015-03-09 2018-04-11 Panasonic Intellectual Property Management Co., Ltd. Microfluid device
US10254298B1 (en) 2015-03-25 2019-04-09 National Technology & Engineering Solutions Of Sandia, Llc Detection of metabolites for controlled substances
KR101891890B1 (en) 2015-10-23 2018-08-28 울산과학기술원 Centrifugal force-baced nano particle isolation device, and nano particle isolation methods
USD799715S1 (en) 2015-10-23 2017-10-10 Gene POC, Inc. Fluidic centripetal device
WO2017069573A1 (en) * 2015-10-23 2017-04-27 울산과학기술원 Centrifugal force-based nanoparticle separation apparatus and method for separating nanoparticles using the same
CN107427829A (en) * 2015-12-16 2017-12-01 拜奥塞菲特公司 Method and apparatus for treatment liquid
WO2017112793A1 (en) 2015-12-21 2017-06-29 Tasso, Inc. Devices, systems and methods for actuation and retraction in fluid collection
US11331665B2 (en) 2016-01-18 2022-05-17 The Board Of Trustees Of The Leland Stanford Junior University Paperfuge: An integrated paper-based centrifugation and microfluidics platform for low-cost diagnostics
FR3048778A1 (en) * 2016-03-10 2017-09-15 Archimej Tech ANALYSIS DEVICE, PREFERABLY FOR CHEMOMETRY OF A BLOOD SAMPLE.
JP7072228B2 (en) 2016-06-08 2022-05-20 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Methods and equipment for treating tissues and cells
US10525470B2 (en) 2016-06-09 2020-01-07 Biosurfit, S.A. Liquid flow control
KR101868961B1 (en) * 2016-06-21 2018-06-19 울산과학기술원 Microfluidic devices
WO2018009756A1 (en) * 2016-07-07 2018-01-11 Vanderbilt University Fluidic device for the detection, capture, or removal of a disease material
CN106076445B (en) * 2016-07-18 2018-06-15 天津德祥生物技术有限公司 Micro-fluidic reagent card and its detection method and application
US10981174B1 (en) 2016-08-04 2021-04-20 National Technology & Engineering Solutions Of Sandia, Llc Protein and nucleic acid detection for microfluidic devices
US10406528B1 (en) 2016-08-04 2019-09-10 National Technology & Engineering Solutions Of Sandia, Llc Non-contact temperature control system for microfluidic devices
US10786811B1 (en) 2016-10-24 2020-09-29 National Technology & Engineering Solutions Of Sandia, Llc Detection of active and latent infections with microfluidic devices and systems thereof
KR102026313B1 (en) 2016-11-10 2019-09-30 울산대학교 산학협력단 3-dimensional channel construct
GB201700340D0 (en) * 2017-01-09 2017-02-22 Gsg Tech Ltd fluid manipulation cartridge and controller mechanism
TWI671397B (en) * 2017-07-14 2019-09-11 國立中興大學 Granular body extraction device
CN111246943B (en) * 2017-08-15 2021-06-22 通用医疗公司 Method and system for integrated multiplexed modular light metering
CN111247433B (en) * 2017-10-23 2023-05-30 国立大学法人山梨大学 Dispensing apparatus, dispensing device and method using the same, and inspection device and method
IT201800006089A1 (en) * 2018-06-06 2019-12-06 MICROFLUIDIC DEVICE FOR THE CONCENTRATION OF PARTICLES
DE102018212930B3 (en) * 2018-08-02 2019-11-07 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Apparatus and method for passing a liquid through a porous medium
US11628452B2 (en) * 2018-08-24 2023-04-18 Zoetis Services Llc Microfluidic rotor device
EP4278983A3 (en) 2018-09-14 2023-12-20 Tasso, Inc. Bodily fluid collection device
CN109211860B (en) * 2018-09-29 2023-11-17 厦门大学 Polynomial detection optical disc and detection method
AU2019363719B2 (en) * 2018-10-24 2023-10-26 Danmarks Tekniske Universitet Multi function spinning platform
CN110237775A (en) * 2019-06-18 2019-09-17 金华职业技术学院 A kind of micro liquid hybrid reaction method
CN110180465A (en) * 2019-06-18 2019-08-30 金华职业技术学院 A kind of micro liquid mixed reactor
CN112807656B (en) * 2020-12-31 2022-02-25 吉林师范大学 A new people trainer for basketball shooting
GB202201074D0 (en) * 2021-07-29 2022-03-16 Osler Diagnostics Ltd Liquid handling device for allowing the presence or absence of a volume of liquid to be determined
CN114471765B (en) * 2022-01-18 2023-04-21 北京保利微芯科技有限公司 Centrifugal liquid drop generating chip
US20230381393A1 (en) * 2022-05-27 2023-11-30 Actorius Innovations Research Co Devices and methods for recovering disease-causing toxic constituents in the blood

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3679367A (en) * 1970-09-14 1972-07-25 Technicon Instr Apparatus for determining the pack volume of particulates in liquid mixtures
BE792465A (en) * 1971-12-09 1973-03-30 Atomic Energy Commission PERFECTED ROTOR FOR ROTARY PHOTOMETRIC ANALYZER, ESPECIALLY SUITABLE IN WEIGHTNESS CONDITIONS
US4030834A (en) * 1976-04-08 1977-06-21 The United States Of America As Represented By The United States Energy Research And Development Administration Dynamic multistation photometer
FR2400700A1 (en) * 1977-08-18 1979-03-16 Guigan Jean CONDITIONING DEVICE FOR A LIQUID SAMPLE FOR ANALYSIS
US4760067A (en) 1979-08-15 1988-07-26 Merck & Co., Inc. Allylsulfoxide enzyme inhibitors
US5496520A (en) * 1982-01-08 1996-03-05 Kelton; Arden A. Rotary fluid manipulator
US4675285A (en) 1984-09-19 1987-06-23 Genetics Institute, Inc. Method for identification and isolation of DNA encoding a desired protein
FR2575293B1 (en) * 1984-12-21 1987-03-20 Inovelf Sa DYNAMIC PIPETTING ROTOR FOR CENTRIFUGAL ANALYSIS DEVICE
US5164598A (en) 1985-08-05 1992-11-17 Biotrack Capillary flow device
US5242803A (en) * 1987-07-17 1993-09-07 Martin Marietta Energy Systems, Inc. Rotor assembly and assay method
US5173262A (en) * 1987-07-17 1992-12-22 Martin Marietta Energy Systems, Inc. Rotor assembly and method for automatically processing liquids
US5160702A (en) * 1989-01-17 1992-11-03 Molecular Devices Corporation Analyzer with improved rotor structure
US5166322A (en) 1989-04-21 1992-11-24 Genetics Institute Cysteine added variants of interleukin-3 and chemical modifications thereof
US5061381A (en) * 1990-06-04 1991-10-29 Abaxis, Inc. Apparatus and method for separating cells from biological fluids
US5173193A (en) * 1991-04-01 1992-12-22 Schembri Carol T Centrifugal rotor having flow partition
US5186844A (en) * 1991-04-01 1993-02-16 Abaxis, Inc. Apparatus and method for continuous centrifugal blood cell separation
US5122284A (en) * 1990-06-04 1992-06-16 Abaxis, Inc. Apparatus and method for optically analyzing biological fluids
US5242606A (en) * 1990-06-04 1993-09-07 Abaxis, Incorporated Sample metering port for analytical rotor having overflow chamber
US5427959A (en) * 1990-10-01 1995-06-27 Canon Kabushiki Kaisha Apparatus and method for measuring specimen
US5569779A (en) 1991-12-23 1996-10-29 Albemarle Corporation Polyfunctional michael addition products
US5304348A (en) * 1992-02-11 1994-04-19 Abaxis, Inc. Reagent container for analytical rotor
AU4047493A (en) * 1992-04-02 1993-11-08 Abaxis, Inc. Analytical rotor with dye mixing chamber
US5478750A (en) * 1993-03-31 1995-12-26 Abaxis, Inc. Methods for photometric analysis
US5409665A (en) * 1993-09-01 1995-04-25 Abaxis, Inc. Simultaneous cuvette filling with means to isolate cuvettes
US5591643A (en) * 1993-09-01 1997-01-07 Abaxis, Inc. Simplified inlet channels
US5446090A (en) 1993-11-12 1995-08-29 Shearwater Polymers, Inc. Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
US5976896A (en) * 1994-06-06 1999-11-02 Idexx Laboratories, Inc. Immunoassays in capillary tubes
US5639428A (en) * 1994-07-19 1997-06-17 Becton Dickinson And Company Method and apparatus for fully automated nucleic acid amplification, nucleic acid assay and immunoassay
EP0865606B1 (en) 1995-12-05 2005-03-16 Gamera Bioscience Corporation Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system with on-board informatics
US20010055812A1 (en) * 1995-12-05 2001-12-27 Alec Mian Devices and method for using centripetal acceleration to drive fluid movement in a microfluidics system with on-board informatics
US6143248A (en) * 1996-08-12 2000-11-07 Gamera Bioscience Corp. Capillary microvalve
AU5895898A (en) 1996-12-20 1998-07-17 Gamera Bioscience Corporation An affinity binding-based system for detecting particulates in a fluid
JP3469585B2 (en) * 1997-05-23 2003-11-25 ガメラ バイオサイエンス コーポレイション Apparatus and method for using centripetal acceleration to drive flow motion in microfluidics systems
GB9808836D0 (en) 1998-04-27 1998-06-24 Amersham Pharm Biotech Uk Ltd Microfabricated apparatus for cell based assays
GB9809943D0 (en) * 1998-05-08 1998-07-08 Amersham Pharm Biotech Ab Microfluidic device
US6361958B1 (en) * 1999-11-12 2002-03-26 Motorola, Inc. Biochannel assay for hybridization with biomaterial
ATE329691T1 (en) * 1999-12-23 2006-07-15 Gyros Patent Ab METHOD FOR TREATING A MATRIX NUCLEIC ACID USING AN INTEGRATED MICROFLUIDIC PLATE

Also Published As

Publication number Publication date
EP1284817A2 (en) 2003-02-26
US6527432B2 (en) 2003-03-04
AU2001259785A1 (en) 2001-11-26
JP2003533681A (en) 2003-11-11
WO2001087486A3 (en) 2002-10-24
WO2001087487A3 (en) 2002-04-18
EP1284818A2 (en) 2003-02-26
DE60124699T2 (en) 2007-09-13
EP1284818B1 (en) 2006-11-22
US20020106786A1 (en) 2002-08-08
US6818435B2 (en) 2004-11-16
US20020097632A1 (en) 2002-07-25
US20030152491A1 (en) 2003-08-14
DE60124699D1 (en) 2007-01-04
ATE345868T1 (en) 2006-12-15
WO2001087487A2 (en) 2001-11-22
WO2001087486A2 (en) 2001-11-22
JP2003533682A (en) 2003-11-11

Similar Documents

Publication Publication Date Title
AU2001259786A1 (en) Bidirectional flow centrifugal microfluidic devices
WO2005028096A3 (en) Microfluidics devices and methods for performing cell based assays
AU5494900A (en) Devices and methods for the performance of miniaturized homogeneous assays
WO2002101357A3 (en) Molecular signatures of commonly fatal carcinomas
WO2004058406A3 (en) Microfluidics devices and methods for diluting samples and reagents
WO2004051218A3 (en) Multiplex amplification of polynucleotides
WO2005068628A3 (en) Methods for nucleic acid isolation and kits using solid phase material
EP2305809A3 (en) Methods for nucleic acid isolation and kits using a microfluidic device and concentration step
DE60211651D1 (en) PROTEOME ANALYSIS PROCEDURE
DK1439897T3 (en) Methods for separating rare cells from fluid samples
WO2005002416A3 (en) Predictors of renal disease
WO2003008933A3 (en) Test strip for a lateral flow assay
EP2260942A3 (en) Protease Inhibitor Sample Collection System
WO2003064993A3 (en) Methods and materials for detecting genetic material
AU2002320507A1 (en) Microfluidic devices and systems for separating components of a mixture
WO2004092702A3 (en) Microfluidic detection device
HK1152378A1 (en) Labeled cells for use as an internal functional control in rare cell detection assays
WO2003065976A3 (en) Microfluidics apparatus and methods of use therefor
AU2001241433A1 (en) Methods for predicting the biological, chemical, and physical properties of molecules from their spectral properties
WO2003106964A3 (en) High throughput methods and devices for assaying analytes in a fluid sample
WO2002059379A3 (en) Methods for detecting, grading or monitoring an $i(h. pylori) infection
CA2500407A1 (en) Diagnostic devices
DE60210600D1 (en) MICRO FLUID FRACTION COLLECTORS
WO2005095653A3 (en) Method for collecting purified cells
WO2003050291A3 (en) Sensor for the use in testing biological chemical or environmental samples