AU2001255495A1 - Ribavirin-interferon alfa combination therapy for eradicating detectable hcv-rnain patients having chronic hepatitis c infection - Google Patents
Ribavirin-interferon alfa combination therapy for eradicating detectable hcv-rnain patients having chronic hepatitis c infectionInfo
- Publication number
- AU2001255495A1 AU2001255495A1 AU2001255495A AU5549501A AU2001255495A1 AU 2001255495 A1 AU2001255495 A1 AU 2001255495A1 AU 2001255495 A AU2001255495 A AU 2001255495A AU 5549501 A AU5549501 A AU 5549501A AU 2001255495 A1 AU2001255495 A1 AU 2001255495A1
- Authority
- AU
- Australia
- Prior art keywords
- rnain
- ribavirin
- infection
- patients
- combination therapy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/056—Triazole or tetrazole radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19880100P | 2000-04-20 | 2000-04-20 | |
US60198801 | 2000-04-20 | ||
PCT/US2001/012760 WO2001081359A1 (en) | 2000-04-20 | 2001-04-18 | Ribavirin-interferon alfa combination therapy for eradicating detectable hcv-rna in patients having chronic hepatitis c infection |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001255495A1 true AU2001255495A1 (en) | 2001-11-07 |
Family
ID=22734903
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001255495A Abandoned AU2001255495A1 (en) | 2000-04-20 | 2001-04-18 | Ribavirin-interferon alfa combination therapy for eradicating detectable hcv-rnain patients having chronic hepatitis c infection |
Country Status (5)
Country | Link |
---|---|
US (2) | US6924270B2 (en) |
EP (1) | EP1282632A1 (en) |
AR (1) | AR031572A1 (en) |
AU (1) | AU2001255495A1 (en) |
WO (1) | WO2001081359A1 (en) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2001255495A1 (en) | 2000-04-20 | 2001-11-07 | Schering Corporation | Ribavirin-interferon alfa combination therapy for eradicating detectable hcv-rnain patients having chronic hepatitis c infection |
MY164523A (en) * | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
EA200601591A1 (en) | 2000-05-26 | 2007-02-27 | Айденикс (Кайман) Лимитед | APPLICATION OF RIBONOUSALIC COMPOUNDS FOR TREATING FLAVIVIRUS AND PESTIVIRUS INFECTIONS |
US20060024270A1 (en) * | 2000-08-23 | 2006-02-02 | The New York Hospital Medical Center Of Queens | Compositions and methods for preventing or treating encephalitis with interferon |
HUP0301444A3 (en) * | 2000-10-18 | 2007-05-29 | Schering Corp | The use of ribavirin-pegylated interferon alfa for the preparation of pharmaceutical compositions for the treatment of hcv infection |
US7608600B2 (en) | 2002-06-28 | 2009-10-27 | Idenix Pharmaceuticals, Inc. | Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections |
NZ537662A (en) * | 2002-06-28 | 2007-10-26 | Idenix Cayman Ltd | 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
BR0312278A (en) * | 2002-06-28 | 2007-06-19 | Idenix Cayman Ltd | 2'-c-methyl-3'-o-1-valine ribofuranosyl cytidine ester for treatment of flaviviridae infections |
JP2005533817A (en) | 2002-06-28 | 2005-11-10 | イデニクス(ケイマン)リミテツド | Modified 2 'and 3'-nucleoside prodrugs for the treatment of Flaviviridae virus infection |
US8476254B2 (en) | 2002-07-02 | 2013-07-02 | Corcept Therapeutics, Inc. | Methods for treating psychosis associated with interferson-α therapy |
EP1576138B1 (en) | 2002-11-15 | 2017-02-01 | Idenix Pharmaceuticals LLC. | 2'-methyl nucleosides in combination with interferon and flaviviridae mutation |
AU2003300901A1 (en) * | 2002-12-12 | 2004-06-30 | Idenix (Cayman) Limited | Process for the production of 2'-branched nucleosides |
AU2003300434A1 (en) * | 2002-12-23 | 2004-07-22 | Idenix (Cayman) Limited | Process for the production of 3'-nucleoside prodrugs |
ES2726998T3 (en) | 2003-05-30 | 2019-10-11 | Gilead Pharmasset Llc | Modified fluorinated nucleoside analogs |
ATE388963T1 (en) | 2003-08-07 | 2008-03-15 | Zymogenetics Inc | HOMOGENEOUS PRODUCTIONS OF IL-29 |
US20070202078A1 (en) * | 2003-08-13 | 2007-08-30 | Smith Howard J | Method Of Treating Viral Infections |
CA2537849A1 (en) * | 2003-09-11 | 2005-03-17 | F. Hoffmann-La Roche Ag | Process for preparing antiviral nucleoside derivatives |
WO2005097165A2 (en) | 2004-04-02 | 2005-10-20 | Zymogenetics, Inc. | Il-28 and il-29 cysteine mutants for treating viral infection |
US20060040944A1 (en) * | 2004-06-23 | 2006-02-23 | Gilles Gosselin | 5-Aza-7-deazapurine derivatives for treating Flaviviridae |
PT3109244T (en) | 2004-09-14 | 2019-06-04 | Gilead Pharmasset Llc | Preparation of 2'fluoro-2'-alkyl-substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives |
CA2583026A1 (en) * | 2004-10-29 | 2006-05-04 | Intercell Ag | Hcv vaccines for chronic hcv patients |
EP1951748B1 (en) | 2005-11-11 | 2013-07-24 | Vertex Pharmaceuticals, Inc. | Hepatitis c virus variants |
US7705138B2 (en) * | 2005-11-11 | 2010-04-27 | Vertex Pharmaceuticals Incorporated | Hepatitis C virus variants |
US7781576B2 (en) * | 2005-12-23 | 2010-08-24 | Idenix Pharmaceuticals, Inc. | Process for preparing a synthetic intermediate for preparation of branched nucleosides |
US7964580B2 (en) | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
JP5793084B2 (en) | 2008-12-23 | 2015-10-14 | ギリアド ファーマセット エルエルシー | Synthesis of purine nucleosides |
BRPI0922508A8 (en) | 2008-12-23 | 2016-01-19 | Pharmasset Inc | NUCLEOSID ANALOGS |
CA2748057C (en) | 2008-12-23 | 2018-07-03 | Pharmasset, Inc. | Nucleoside phosphoramidates |
TWI598358B (en) | 2009-05-20 | 2017-09-11 | 基利法瑪席特有限責任公司 | Nucleoside phosphoramidates |
US8618076B2 (en) | 2009-05-20 | 2013-12-31 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
CN102858790A (en) | 2010-03-31 | 2013-01-02 | 吉利德制药有限责任公司 | Nucleoside Phosphoramidates |
EP2585065A1 (en) | 2010-06-24 | 2013-05-01 | Panmed Ltd. | Treatment of hepatitis c virus related diseases using hydroxychloroquine or a combination of hydroxychloroquine and an anti-viral agent |
AU2011311706B2 (en) | 2010-10-05 | 2015-11-12 | Debiopharm S.A. | New treatments of Hepatitis C virus infection |
BR112013013166A2 (en) * | 2010-11-30 | 2016-09-06 | Novartis Ag | hepatitis c virus infection treatments |
PT3042910T (en) | 2010-11-30 | 2019-04-16 | Gilead Pharmasset Llc | 2'-spiro-nucleosides for use in the therapy of hepatitis c |
BR112013025021A2 (en) | 2011-03-31 | 2017-03-01 | Novartis Ag | alisporivir to treat hepatitis virus infections c. |
MX2013011941A (en) | 2011-04-13 | 2014-05-28 | Debiopharm Int Sa | Treatment of hepatitis c virus infection with alisporivir. |
US8912141B2 (en) | 2011-06-23 | 2014-12-16 | Panmed Ltd. | Treatment of hepatitis C virus |
SG10201602044WA (en) | 2011-09-16 | 2016-04-28 | Gilead Pharmassett Llc | Methods For Treating HCV |
BR112014007247A2 (en) * | 2011-09-27 | 2017-03-28 | Novartis Ag | alisporivir for the treatment of hepatitis C virus infection |
US8889159B2 (en) | 2011-11-29 | 2014-11-18 | Gilead Pharmasset Llc | Compositions and methods for treating hepatitis C virus |
CA2852867C (en) | 2013-01-31 | 2016-12-06 | Gilead Pharmasset Llc | Combination formulation of two antiviral compounds |
WO2014122537A2 (en) | 2013-02-05 | 2014-08-14 | Genoscience Sa | Pharmaceutical compositions and methods of treating hepatitis c virus infection using a combination of hydroxychloroquine and ribavirin |
MX2016002185A (en) | 2013-08-27 | 2016-06-06 | Gilead Pharmasset Llc | Combination formulation of two antiviral compounds. |
CN111320662B (en) * | 2020-02-17 | 2022-11-25 | 南京医科大学 | N-benzyl substituted diamidinonazine derivative and pharmaceutical application thereof |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3984396A (en) * | 1971-06-01 | 1976-10-05 | Icn Pharmaceuticals, Inc. | 1-(β,-D-ribofuranosyl)-1,2,4-triazole acid esters |
US4211771A (en) * | 1971-06-01 | 1980-07-08 | Robins Ronald K | Treatment of human viral diseases with 1-B-D-ribofuranosyl-1,2,4-triazole-3-carboxamide |
GB1482736A (en) | 1974-03-18 | 1977-08-10 | Icn Pharmaceuticals | 1-(beta-d-ribofuranosyl)-1,2,4-triazole acid derivatives |
US4544741A (en) | 1982-03-29 | 1985-10-01 | Robins Roland K | Azole dinucleotide compounds and methods for their production |
US5674911A (en) | 1987-02-20 | 1997-10-07 | Cytrx Corporation | Antiinfective polyoxypropylene/polyoxyethylene copolymers and methods of use |
US4925930A (en) | 1988-11-02 | 1990-05-15 | Nucleic Acid Research Institute | Synthesis and anti-leukemic activity of alkyl-1-(β-D-ribofuranosyl)[1,2,4]triazole-3-carboximidates |
JPH07503851A (en) * | 1992-02-10 | 1995-04-27 | インターフェロン・サイエンシズ、インコーポレイテッド | Improved interferon and its production method from human peripheral blood leukocytes |
GB9307043D0 (en) * | 1993-04-05 | 1993-05-26 | Norsk Hydro As | Chemical compounds |
US5681811A (en) | 1993-05-10 | 1997-10-28 | Protein Delivery, Inc. | Conjugation-stabilized therapeutic agent compositions, delivery and diagnostic formulations comprising same, and method of making and using the same |
US6387365B1 (en) * | 1995-05-19 | 2002-05-14 | Schering Corporation | Combination therapy for chronic hepatitis C infection |
US5981507A (en) | 1995-12-14 | 1999-11-09 | Advanced Magnetics, Inc. | Polymeric carriers linked to nucleotide analogues via a phosphoramide bond |
TW517067B (en) | 1996-05-31 | 2003-01-11 | Hoffmann La Roche | Interferon conjugates |
CA2271135A1 (en) | 1996-11-12 | 1998-05-22 | Medivir Ab | Nucleosides |
NZ510811A (en) * | 1998-10-16 | 2003-06-30 | Schering Corp | Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection |
US6403564B1 (en) * | 1998-10-16 | 2002-06-11 | Schering Corporation | Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection |
US6277830B1 (en) * | 1998-10-16 | 2001-08-21 | Schering Corporation | 5′-amino acid esters of ribavirin and the use of same to treat hepatitis C with interferon |
AU2001255495A1 (en) | 2000-04-20 | 2001-11-07 | Schering Corporation | Ribavirin-interferon alfa combination therapy for eradicating detectable hcv-rnain patients having chronic hepatitis c infection |
US6673775B2 (en) | 2001-04-18 | 2004-01-06 | Schering Corporation | Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection |
-
2001
- 2001-04-18 AU AU2001255495A patent/AU2001255495A1/en not_active Abandoned
- 2001-04-18 WO PCT/US2001/012760 patent/WO2001081359A1/en active Application Filing
- 2001-04-18 EP EP01928662A patent/EP1282632A1/en not_active Withdrawn
- 2001-04-18 US US09/837,491 patent/US6924270B2/en not_active Expired - Fee Related
- 2001-04-19 AR ARP010101840A patent/AR031572A1/en unknown
-
2004
- 2004-07-06 US US10/885,374 patent/US7115578B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AR031572A1 (en) | 2003-09-24 |
US6924270B2 (en) | 2005-08-02 |
WO2001081359A1 (en) | 2001-11-01 |
US20050004053A1 (en) | 2005-01-06 |
US20020055473A1 (en) | 2002-05-09 |
EP1282632A1 (en) | 2003-02-12 |
US7115578B2 (en) | 2006-10-03 |
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