AU2001250820A1 - Novel cyclohexene derivatives useful as antagonists of the motilin receptor - Google Patents

Novel cyclohexene derivatives useful as antagonists of the motilin receptor

Info

Publication number
AU2001250820A1
AU2001250820A1 AU2001250820A AU5082001A AU2001250820A1 AU 2001250820 A1 AU2001250820 A1 AU 2001250820A1 AU 2001250820 A AU2001250820 A AU 2001250820A AU 5082001 A AU5082001 A AU 5082001A AU 2001250820 A1 AU2001250820 A1 AU 2001250820A1
Authority
AU
Australia
Prior art keywords
antagonists
derivatives useful
motilin receptor
cyclohexene derivatives
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001250820A
Inventor
Robert H. Chen
Min A. Xiang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceuticals Inc
Original Assignee
Ortho McNeil Pharmaceutical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho McNeil Pharmaceutical Inc filed Critical Ortho McNeil Pharmaceutical Inc
Publication of AU2001250820A1 publication Critical patent/AU2001250820A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
AU2001250820A 2000-03-13 2001-03-09 Novel cyclohexene derivatives useful as antagonists of the motilin receptor Abandoned AU2001250820A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18873200P 2000-03-13 2000-03-13
US60188732 2000-03-13
PCT/US2001/007701 WO2001068621A1 (en) 2000-03-13 2001-03-09 Novel cyclohexene derivatives useful as antagonists of the motilin receptor

Publications (1)

Publication Number Publication Date
AU2001250820A1 true AU2001250820A1 (en) 2001-09-24

Family

ID=22694307

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001250820A Abandoned AU2001250820A1 (en) 2000-03-13 2001-03-09 Novel cyclohexene derivatives useful as antagonists of the motilin receptor

Country Status (4)

Country Link
US (1) US6423714B2 (en)
AR (1) AR029896A1 (en)
AU (1) AU2001250820A1 (en)
WO (1) WO2001068621A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7521420B2 (en) 2003-06-18 2009-04-21 Tranzyme Pharma, Inc. Macrocyclic antagonists of the motilin receptor
CN100502722C (en) * 2004-01-29 2009-06-24 应用材料公司 Methods and apparatus for installing a scrubber brush on a mandrel
US7596395B2 (en) * 2004-10-21 2009-09-29 Nokia Corporation Depressible hinge and mobile stations using same
GB0611907D0 (en) 2006-06-15 2006-07-26 Glaxo Group Ltd Compounds
WO2006094933A1 (en) 2005-03-08 2006-09-14 Nycomed Gmbh Roflumilast for the treatment of diabetes mellitus
WO2007007018A1 (en) 2005-07-12 2007-01-18 Glaxo Group Limited Piperazine heteroaryl derivates as gpr38 agonists
AU2006274212B2 (en) 2005-07-26 2011-06-09 Glaxo Group Limited Benzylpiperazine derivates and their medical use
JP2009529241A (en) * 2006-03-07 2009-08-13 アプライド マテリアルズ インコーポレイテッド Scrubber brush with sleeve and brush mandrel for use with a scrubber brush
EA015820B1 (en) * 2006-06-28 2011-12-30 Глэксо Груп Лимитед Piperazinyl derivatives useful in the treatment of gpr38 receptor mediated diseases
US9133235B2 (en) 2006-09-11 2015-09-15 Ocera Therapeutics, Inc. Macrocyclic antagonists of the motilin receptor for treatment of gastrointestinal dysmotility disorders
US20080287371A1 (en) * 2007-05-17 2008-11-20 Tranzyme Pharma Inc. Macrocyclic antagonists of the motilin receptor for modulation of the migrating motor complex
MX2011008857A (en) 2009-02-27 2011-09-30 Raqualia Pharma Inc Oxyindole derivatives with motilin receptor agonistic activity.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU202195B (en) * 1987-12-31 1991-02-28 Egyt Gyogyszervegyeszeti Gyar Process for producing new substituted styrene derivatives and medical compositions comprising such compounds
FR2636628B1 (en) 1988-08-25 1990-12-28 Sanofi Sa THIADIAZOLE-1,3,4 DERIVATIVES, PROCESS FOR OBTAINING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
PT777659E (en) 1994-08-15 2001-09-28 Merck Sharp & Dohme MORPHINE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS
US5972939A (en) 1997-10-28 1999-10-26 Ortho-Mcneil Pharmaceutical, Inc. Cyclopentene derivatives useful as antagonists of the motilin receptor

Also Published As

Publication number Publication date
AR029896A1 (en) 2003-07-23
US20020002192A1 (en) 2002-01-03
WO2001068621A1 (en) 2001-09-20
US6423714B2 (en) 2002-07-23

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