AU2001243435A1 - Intermediates useful for the synthesis of huperzine a - Google Patents

Intermediates useful for the synthesis of huperzine a

Info

Publication number
AU2001243435A1
AU2001243435A1 AU2001243435A AU4343501A AU2001243435A1 AU 2001243435 A1 AU2001243435 A1 AU 2001243435A1 AU 2001243435 A AU2001243435 A AU 2001243435A AU 4343501 A AU4343501 A AU 4343501A AU 2001243435 A1 AU2001243435 A1 AU 2001243435A1
Authority
AU
Australia
Prior art keywords
huperzine
synthesis
intermediates useful
intermediates
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001243435A
Inventor
Alan P Kozikowski
Werner Tuckmantel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Georgetown University
Original Assignee
Georgetown University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Georgetown University filed Critical Georgetown University
Publication of AU2001243435A1 publication Critical patent/AU2001243435A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AU2001243435A 2000-03-08 2001-03-06 Intermediates useful for the synthesis of huperzine a Abandoned AU2001243435A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/520,497 US6271379B1 (en) 2000-03-08 2000-03-08 Intermediates useful for the synthesis of huperzine A
US09520497 2000-03-08
PCT/US2001/007059 WO2001066524A2 (en) 2000-03-08 2001-03-06 Intermediates useful for the synthesis of huperzine a

Publications (1)

Publication Number Publication Date
AU2001243435A1 true AU2001243435A1 (en) 2001-09-17

Family

ID=24072849

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001243435A Abandoned AU2001243435A1 (en) 2000-03-08 2001-03-06 Intermediates useful for the synthesis of huperzine a

Country Status (3)

Country Link
US (1) US6271379B1 (en)
AU (1) AU2001243435A1 (en)
WO (1) WO2001066524A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005115471A2 (en) * 2004-05-27 2005-12-08 Neurocure Ltd. Methods and compositions for treatment of nicotine dependence and dementias
US20090247754A1 (en) * 2008-03-25 2009-10-01 Debiopharm S.A. Method of preparing huperzine a and derivatives thereof
US10059672B2 (en) * 2011-03-04 2018-08-28 Yale University (−)-Huperzine A processes and related compositions and methods of treatment
CN109705038B (en) * 2017-10-25 2020-11-03 广州市朗启医药科技有限责任公司 Synthesis method of huperzine A

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5177082A (en) * 1985-11-05 1993-01-05 Yu Chao Mei Huperzines and analogs
US4929731A (en) 1989-02-21 1990-05-29 University Of Pittsburgh Method for the synthesis of huperzine A and analogs thereof and compounds useful therein
US5106979A (en) 1989-02-21 1992-04-21 University Of Pittsburgh Method for the synthesis of huperzine A and analogs thereof and compounds useful therein
US5104880A (en) 1991-05-01 1992-04-14 Mayo Foundation For Medical Education And Research Huperzine a analogs as acetylcholinesterase inhibitors
US5547960A (en) 1994-09-07 1996-08-20 Mayo Foundation For Medical Education And Research C-10 analogs of huperzine a
JPH08301850A (en) * 1995-05-01 1996-11-19 Sagami Chem Res Center Production of optically active 5,9-methanocycloocta(b)pyridine derivative
JPH08301851A (en) * 1995-05-01 1996-11-19 Sagami Chem Res Center Production of optically active 5,9-methanocycloocta(b)pyridine derivative
JPH1036352A (en) * 1996-07-23 1998-02-10 Sagami Chem Res Center (11e)-5-amino-11-ethylidene-5,6,9,10-tetrahydro-5,9-methanocycloocta(b)pyridin-2-(1h)-one derivative and production intermediate therefor
JPH10158289A (en) * 1996-11-27 1998-06-16 Sagami Chem Res Center Optically active ferrocenylphosphine derivative and production of optically active 5,9-methanocycloocta(b)pyridine derivative
AU8925998A (en) 1997-09-03 1999-03-22 Macro Hi-Tech Jv, Ltd. Huperzine a derivatives

Also Published As

Publication number Publication date
WO2001066524A3 (en) 2002-02-28
WO2001066524A2 (en) 2001-09-13
US6271379B1 (en) 2001-08-07

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