AU2001239625A1 - Method of preparing solid dispersions - Google Patents

Method of preparing solid dispersions

Info

Publication number
AU2001239625A1
AU2001239625A1 AU2001239625A AU3962501A AU2001239625A1 AU 2001239625 A1 AU2001239625 A1 AU 2001239625A1 AU 2001239625 A AU2001239625 A AU 2001239625A AU 3962501 A AU3962501 A AU 3962501A AU 2001239625 A1 AU2001239625 A1 AU 2001239625A1
Authority
AU
Australia
Prior art keywords
methods
solid dispersions
substances
preparing solid
dispersions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001239625A
Inventor
Arne Brodin
Sylvan Frank
Chao Ye
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE0000934A external-priority patent/SE0000934D0/en
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of AU2001239625A1 publication Critical patent/AU2001239625A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Anesthesiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Colloid Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)

Abstract

The present invention is directed to improved methods for producing solid dispersions, especially pharmaceutical dispersions. These methods involve the dissolution of one or more insoluble or relatively insoluble substances, preferably pharmaceutically active substances, and/or one or more water-soluble substances, preferably carriers, in supercritical fluids and the subsequent removal of solvent by rapid expansion. These methods offer a number of advantages over traditional preparation methods and form formulations with highly desirable dissolution properties, especially for pharmaceuticals.
AU2001239625A 2000-03-09 2001-03-08 Method of preparing solid dispersions Abandoned AU2001239625A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US18798400P 2000-03-09 2000-03-09
US60187984 2000-03-09
SE0000934 2000-03-21
SE0000934A SE0000934D0 (en) 2000-03-21 2000-03-21 Method of preparing pharmaceutical compositions
PCT/SE2001/000499 WO2001066091A1 (en) 2000-03-09 2001-03-08 Method of preparing solid dispersions

Publications (1)

Publication Number Publication Date
AU2001239625A1 true AU2001239625A1 (en) 2001-09-17

Family

ID=26655029

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001239625A Abandoned AU2001239625A1 (en) 2000-03-09 2001-03-08 Method of preparing solid dispersions

Country Status (11)

Country Link
US (1) US20030104065A1 (en)
EP (1) EP1263413B1 (en)
JP (1) JP2003525895A (en)
AT (1) ATE326949T1 (en)
AU (1) AU2001239625A1 (en)
CY (1) CY1105515T1 (en)
DE (1) DE60119905T2 (en)
DK (1) DK1263413T3 (en)
ES (1) ES2263600T3 (en)
PT (1) PT1263413E (en)
WO (1) WO2001066091A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10026698A1 (en) 2000-05-30 2001-12-06 Basf Ag Self-emulsifying active ingredient formulation and use of this formulation
US8377952B2 (en) 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
DE10358749A1 (en) * 2003-12-12 2005-07-14 Lts Lohmann Therapie-Systeme Ag Dosage form for combating primary headache
EP1904219A4 (en) 2005-07-15 2011-07-27 Map Pharmaceuticals Inc Method of particle formation
EP2170284B1 (en) * 2007-07-18 2011-08-24 Feyecon B.V. A method of preparing a pharmaceutical co-crystal composition
KR101704081B1 (en) * 2009-05-29 2017-02-07 모리시타 진탄 가부시키가이샤 Oral medicinal composition and oral medicinal capsule having the composition encapsulated therein
US20140066843A1 (en) * 2011-03-07 2014-03-06 3M Innovative Properties Company Microneedle devices and methods
FR2987266B1 (en) * 2012-02-28 2014-12-19 Debregeas Et Associes Pharma PROCESS FOR OBTAINING A PHARMACEUTICAL COMPOSITION BASED ON MODAFINIL, PHARMACEUTICAL COMPOSITION THUS OBTAINED AND ITS APPLICATION
WO2015071841A1 (en) 2013-11-12 2015-05-21 Druggability Technologies Holdings Limited Complexes of dabigatran and its derivatives, process for the preparation thereof and pharmaceutical compositions containing them
CN108096195B (en) * 2018-01-08 2020-01-24 中国药科大学 Method for preparing azilsartan solid dispersion by supercritical anti-solvent method

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5169433A (en) * 1990-07-18 1992-12-08 Formulogics, Inc. Method of preparing mixtures of active ingredients and excipients using liquid carbon dioxide
AU5171293A (en) * 1992-10-14 1994-05-09 Regents Of The University Of Colorado, The Ion-pairing of drugs for improved efficacy and delivery
SI9400079B (en) * 1994-02-15 2003-02-28 Dr. Weidner Eckhard, Dipl. Ing. Method and device for extraction and fractionation of small particles from solutions saturated with gas
ID21571A (en) * 1996-10-14 1999-06-24 Hoffmann La Roche POWDER PREPARATION MAKING PROCESS
US5955475A (en) * 1997-06-30 1999-09-21 Endo Pharmaceuticals Inc. Process for manufacturing paroxetine solid dispersions
US6299906B1 (en) * 1998-04-09 2001-10-09 Hoffmann-La Roche Inc. Process for making submicron particles
AU755993C (en) * 1998-06-19 2003-10-30 Skyepharma Canada Inc. Processes to generate submicron particles of water-insoluble compounds
US20020041898A1 (en) * 2000-01-05 2002-04-11 Unger Evan C. Novel targeted delivery systems for bioactive agents

Also Published As

Publication number Publication date
PT1263413E (en) 2006-08-31
EP1263413B1 (en) 2006-05-24
EP1263413A1 (en) 2002-12-11
ATE326949T1 (en) 2006-06-15
WO2001066091A1 (en) 2001-09-13
DE60119905T2 (en) 2007-01-11
US20030104065A1 (en) 2003-06-05
CY1105515T1 (en) 2010-07-28
JP2003525895A (en) 2003-09-02
DE60119905D1 (en) 2006-06-29
DK1263413T3 (en) 2006-09-11
ES2263600T3 (en) 2006-12-16

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