AU2001237633A1 - Method of identifying modulators of presenilin - Google Patents

Method of identifying modulators of presenilin

Info

Publication number
AU2001237633A1
AU2001237633A1 AU2001237633A AU3763301A AU2001237633A1 AU 2001237633 A1 AU2001237633 A1 AU 2001237633A1 AU 2001237633 A AU2001237633 A AU 2001237633A AU 3763301 A AU3763301 A AU 3763301A AU 2001237633 A1 AU2001237633 A1 AU 2001237633A1
Authority
AU
Australia
Prior art keywords
presenilin
identifying modulators
modulators
identifying
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001237633A
Inventor
Walter Blackstock
Richard Stephen Hale
Adele Rowley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of AU2001237633A1 publication Critical patent/AU2001237633A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711Alzheimer's disease; Amyloid plaque core protein
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896Neurological disorders, e.g. Alzheimer's disease
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701Details
    • G01N2333/4709Amyloid plaque core protein
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
    • G01N2800/2814Dementia; Cognitive disorders
    • G01N2800/2821Alzheimer
AU2001237633A 2000-03-10 2001-03-09 Method of identifying modulators of presenilin Abandoned AU2001237633A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0005894.1A GB0005894D0 (en) 2000-03-10 2000-03-10 Assay
GB0005894 2000-03-10
PCT/GB2001/001057 WO2001067109A1 (en) 2000-03-10 2001-03-09 Method of identifying modulators of presenilin

Publications (1)

Publication Number Publication Date
AU2001237633A1 true AU2001237633A1 (en) 2001-09-17

Family

ID=9887438

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001237633A Abandoned AU2001237633A1 (en) 2000-03-10 2001-03-09 Method of identifying modulators of presenilin

Country Status (5)

Country Link
US (1) US20030113811A1 (en)
EP (1) EP1259821A1 (en)
AU (1) AU2001237633A1 (en)
GB (1) GB0005894D0 (en)
WO (1) WO2001067109A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2417136A1 (en) * 2000-09-01 2002-03-07 The Governing Council Of The University Of Toronto Proteins related to schizophrenia and uses thereof
GB0024086D0 (en) * 2000-10-02 2000-11-15 Inpharmatica Ltd Proteinase
WO2005074980A1 (en) * 2004-01-29 2005-08-18 Cellzome Ag Treatment of neurodegenerative diseases by the use of gpr49
US8129334B2 (en) 2006-03-31 2012-03-06 The Regents Of The University Of California Methods and compositions for treating neurodegenerative disorders and Alzheimer'S disease and improving normal memory
AU2007241056A1 (en) 2006-03-31 2007-11-01 The Regents Of The University Of California Methods and compositions for treating neurodegenerative disorders and Alzheimer's disease and improving normal memory

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9608657D0 (en) * 1996-04-26 1996-07-03 Smithkline Beecham Plc Novel treatment
WO2000060069A1 (en) * 1999-04-01 2000-10-12 The Governing Council Of The University Of Toronto A presenilin associated membrane protein and uses thereof

Also Published As

Publication number Publication date
US20030113811A1 (en) 2003-06-19
EP1259821A1 (en) 2002-11-27
WO2001067109A1 (en) 2001-09-13
GB0005894D0 (en) 2000-05-03

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