AU2001237438A1 - Potassium channel protein kcnq5, a target for diseases of central nervous systemand cardiovascular system - Google Patents

Potassium channel protein kcnq5, a target for diseases of central nervous systemand cardiovascular system

Info

Publication number
AU2001237438A1
AU2001237438A1 AU2001237438A AU3743801A AU2001237438A1 AU 2001237438 A1 AU2001237438 A1 AU 2001237438A1 AU 2001237438 A AU2001237438 A AU 2001237438A AU 3743801 A AU3743801 A AU 3743801A AU 2001237438 A1 AU2001237438 A1 AU 2001237438A1
Authority
AU
Australia
Prior art keywords
kcnq5
potassium channel
activity
systemand
diseases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001237438A
Inventor
Andreas Busch
Christian Lerche
Constanze Scherer
Guiscard Seebohm
Klaus Steinmeyer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Aventis Pharma Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland GmbH filed Critical Aventis Pharma Deutschland GmbH
Publication of AU2001237438A1 publication Critical patent/AU2001237438A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

A DNA sequence (I) encoding: (i) a polypeptide (II) with KCNQ5 activity; (ii) a polypeptide with the amino acid (aa) sequence of KCNQ5; (iii) a fully defined sequence (S2) of 932 aa as given in the specification; or (iv) derivatives of S2 with one or more aa deletions or exchanges, is new. Independent claims are also included for the following: (1) proteins encoded by (I); (2) host cells containing at least one (I); and (3) screening assay for identifying compounds (A) that modulate the activity of (II). - ACTIVITY : Neurological; cardiovascular; anticonvulsant. - MECHANISM OF ACTION : Modulation of the voltage-dependent KCNQ5 potassium channel, a key regulator of membrane potential and modulator of excitability of electrically activated cells such as neurons and cardiomyocytes. KCNQ5 may be implicated in some forms of epilepsy.
AU2001237438A 2000-03-21 2001-03-13 Potassium channel protein kcnq5, a target for diseases of central nervous systemand cardiovascular system Abandoned AU2001237438A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10013732 2000-03-21
DE10013732A DE10013732A1 (en) 2000-03-21 2000-03-21 New DNA sequence encoding potassium channel KCNQ5, useful in screening for specific modulators, potential agents for treating central nervous system and cardiovascular diseases
PCT/EP2001/002791 WO2001070811A1 (en) 2000-03-21 2001-03-13 Potassium channel protein kcnq5, a target for diseases of central nervous system and cardiovascular system

Publications (1)

Publication Number Publication Date
AU2001237438A1 true AU2001237438A1 (en) 2001-10-03

Family

ID=7635606

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001237438A Abandoned AU2001237438A1 (en) 2000-03-21 2001-03-13 Potassium channel protein kcnq5, a target for diseases of central nervous systemand cardiovascular system

Country Status (6)

Country Link
EP (1) EP1268545B1 (en)
JP (1) JP5622345B2 (en)
AT (1) ATE336508T1 (en)
AU (1) AU2001237438A1 (en)
DE (2) DE10013732A1 (en)
WO (1) WO2001070811A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000061606A1 (en) * 1999-04-14 2000-10-19 Merck & Co., Inc. Novel human voltage-gated potassium channel
US6649371B1 (en) 1999-06-11 2003-11-18 Neurosearch A/S Potassium channel KCNQ5 and sequences encoding the same
IL152202A0 (en) * 2000-05-26 2003-05-29 Bristol Myers Squibb Co Human kcnq5 polypeptide and pharmaceutical compositions containing the same
US7517960B2 (en) 2006-01-19 2009-04-14 Wyeth Rat KCNQ5 voltage-gated potassium channel

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6403360B1 (en) * 1997-08-12 2002-06-11 Bristol-Myers Squibb Company KCNQ potassium channels and methods of modulating same
CA2307316C (en) * 1997-10-24 2010-12-21 University Of Utah Research Foundation Kcnq2 and kcnq3-potassium channel genes which are mutated in benign familial neonatal convulsions (bfnc) and other epilepsies
GB9726339D0 (en) * 1997-12-13 1998-02-11 Zeneca Ltd Human-derived tissue-specific potassium channel
DK1147134T3 (en) * 1999-01-26 2007-02-05 Neurosearch As New potassium channels and genes encoding these potassium channels
WO2000061606A1 (en) * 1999-04-14 2000-10-19 Merck & Co., Inc. Novel human voltage-gated potassium channel
DE60036548T2 (en) * 1999-06-11 2008-06-26 Neurosearch A/S NEW KALIUM CHANNELS, AND GENES THAT ARE CODED FOR

Also Published As

Publication number Publication date
WO2001070811A1 (en) 2001-09-27
EP1268545A1 (en) 2003-01-02
EP1268545B1 (en) 2006-08-16
DE60122301T2 (en) 2007-09-13
JP2004512009A (en) 2004-04-22
DE10013732A1 (en) 2001-09-27
JP5622345B2 (en) 2014-11-12
DE60122301D1 (en) 2006-09-28
ATE336508T1 (en) 2006-09-15

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