AU2001233785A1 - Electrochemical sensor for determining blood clotting, corresponding system for measuring blood clotting and method for determining blood clotting - Google Patents
Electrochemical sensor for determining blood clotting, corresponding system for measuring blood clotting and method for determining blood clottingInfo
- Publication number
- AU2001233785A1 AU2001233785A1 AU2001233785A AU3378501A AU2001233785A1 AU 2001233785 A1 AU2001233785 A1 AU 2001233785A1 AU 2001233785 A AU2001233785 A AU 2001233785A AU 3378501 A AU3378501 A AU 3378501A AU 2001233785 A1 AU2001233785 A1 AU 2001233785A1
- Authority
- AU
- Australia
- Prior art keywords
- blood clotting
- determining blood
- reagent
- thrombin
- determining
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/974—Thrombin
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The invention relates to a dry chemical based electrochemical sensor for determining blood clotting. The inventive sensor comprises at least 2 electrodes on an inert support, in addition to a dry reagent. The invention is characterized in that the reagent contains a thrombin substitute consisting of a peptide radical which can be cleaved off from thrombin and which is amidically linked to a phenylenediamine radical by the carboxyl end thereof. The invention also relates to a system for measuring blood clotting, comprising one such sensor and a current measurment device. The invention further relates to a method for determining blood clotting with the aid of the inventive sensor and a reagent for determining blood clotting, comprising a thrombin substitute consisting of a peptide radical which can be cleaved off from thrombin and is which is amidically linked to a phenylenediamine radical by the carboxyl end thereof. Said reagent is characterized that it also contains a dye oxidoreductase, such as glucose dye oxidoreductase.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10007910 | 2000-02-21 | ||
DE10007910 | 2000-02-21 | ||
US18405900P | 2000-02-22 | 2000-02-22 | |
US60184059 | 2000-02-22 | ||
DE10016775A DE10016775A1 (en) | 2000-02-21 | 2000-04-04 | Electrochemical sensor for determining blood coagulation, a corresponding blood coagulation measurement system and a method for determining blood coagulation |
DE10016775 | 2000-04-04 | ||
PCT/EP2001/001848 WO2001063271A1 (en) | 2000-02-21 | 2001-02-19 | Electrochemical sensor for determining blood clotting, corresponding system for measuring blood clotting and method for determining blood clotting |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001233785A1 true AU2001233785A1 (en) | 2001-09-03 |
Family
ID=27213672
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001233785A Abandoned AU2001233785A1 (en) | 2000-02-21 | 2001-02-19 | Electrochemical sensor for determining blood clotting, corresponding system for measuring blood clotting and method for determining blood clotting |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1261861B1 (en) |
JP (1) | JP2003524184A (en) |
AT (1) | ATE278186T1 (en) |
AU (1) | AU2001233785A1 (en) |
CA (1) | CA2400651A1 (en) |
WO (1) | WO2001063271A1 (en) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8641644B2 (en) | 2000-11-21 | 2014-02-04 | Sanofi-Aventis Deutschland Gmbh | Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means |
US9795747B2 (en) | 2010-06-02 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Methods and apparatus for lancet actuation |
US7025774B2 (en) | 2001-06-12 | 2006-04-11 | Pelikan Technologies, Inc. | Tissue penetration device |
US9427532B2 (en) | 2001-06-12 | 2016-08-30 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US9226699B2 (en) | 2002-04-19 | 2016-01-05 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling module with a continuous compression tissue interface surface |
US8702624B2 (en) | 2006-09-29 | 2014-04-22 | Sanofi-Aventis Deutschland Gmbh | Analyte measurement device with a single shot actuator |
US9248267B2 (en) | 2002-04-19 | 2016-02-02 | Sanofi-Aventis Deustchland Gmbh | Tissue penetration device |
US7547287B2 (en) | 2002-04-19 | 2009-06-16 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8579831B2 (en) | 2002-04-19 | 2013-11-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US9795334B2 (en) | 2002-04-19 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US8784335B2 (en) | 2002-04-19 | 2014-07-22 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling device with a capacitive sensor |
US9314194B2 (en) | 2002-04-19 | 2016-04-19 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US7713214B2 (en) | 2002-04-19 | 2010-05-11 | Pelikan Technologies, Inc. | Method and apparatus for a multi-use body fluid sampling device with optical analyte sensing |
US8574895B2 (en) | 2002-12-30 | 2013-11-05 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus using optical techniques to measure analyte levels |
WO2006001797A1 (en) | 2004-06-14 | 2006-01-05 | Pelikan Technologies, Inc. | Low pain penetrating |
GB0316075D0 (en) * | 2003-07-09 | 2003-08-13 | Molecular Sensing Plc | Protease detection assay |
US8282576B2 (en) | 2003-09-29 | 2012-10-09 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for an improved sample capture device |
US9351680B2 (en) | 2003-10-14 | 2016-05-31 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a variable user interface |
SE0303249D0 (en) * | 2003-12-02 | 2003-12-02 | Inst Polymerutveckling Ab | Hematocrit and analyte concentration determination |
EP1706026B1 (en) | 2003-12-31 | 2017-03-01 | Sanofi-Aventis Deutschland GmbH | Method and apparatus for improving fluidic flow and sample capture |
WO2006011062A2 (en) | 2004-05-20 | 2006-02-02 | Albatros Technologies Gmbh & Co. Kg | Printable hydrogel for biosensors |
US9775553B2 (en) | 2004-06-03 | 2017-10-03 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a fluid sampling device |
WO2005120365A1 (en) | 2004-06-03 | 2005-12-22 | Pelikan Technologies, Inc. | Method and apparatus for a fluid sampling device |
FR2874385B1 (en) * | 2004-08-18 | 2006-12-08 | Biopep Sa | METHOD AND DEVICE FOR MEASURING ENZYMA ACTIVITY IN A BIOLOGICAL FLUID |
ATE480777T1 (en) * | 2005-07-07 | 2010-09-15 | Asulab Sa | SYSTEM FOR DIFFERENTIAL DETERMINATION OF THE AMOUNT OF A PROTEOLYTIC ENZYME IN A BODY FLUID |
EP1918718A1 (en) * | 2006-10-31 | 2008-05-07 | Roche Diagnostics GmbH | Methods and devices for electrochemical determination of factor Xa inhibitors in blood samples |
TWI516601B (en) * | 2007-10-26 | 2016-01-11 | 環球生物醫療感測器私人有限公司 | Apparatus and method for electrochemical detection |
US8603768B2 (en) * | 2008-01-17 | 2013-12-10 | Lifescan, Inc. | System and method for measuring an analyte in a sample |
EP2265324B1 (en) | 2008-04-11 | 2015-01-28 | Sanofi-Aventis Deutschland GmbH | Integrated analyte measurement system |
EP2144061A1 (en) | 2008-07-11 | 2010-01-13 | F. Hoffmann-Roche AG | Continuous method for inline application of tensides on coated sensor film |
US9375169B2 (en) | 2009-01-30 | 2016-06-28 | Sanofi-Aventis Deutschland Gmbh | Cam drive for managing disposable penetrating member actions with a single motor and motor and control system |
EP2371284A1 (en) * | 2010-03-24 | 2011-10-05 | C A Casyso AG | Method and apparatus for determining at least one evaluation parameter of a blood sample |
US8965476B2 (en) | 2010-04-16 | 2015-02-24 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
TWI472766B (en) * | 2010-06-09 | 2015-02-11 | Apex Biotechnology Corp | Device and method for measuring prothrombin time and hematocrit by analyzing change in reactance in a sample |
DE102011006349A1 (en) * | 2011-03-29 | 2012-10-04 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Device and method for detecting, measuring and / or influencing the clotting of blood systems |
EP2524965A1 (en) * | 2011-05-16 | 2012-11-21 | The Swatch Group Research and Development Ltd. | Increase in storage lifetime of a thrombin sensor |
WO2015098473A1 (en) * | 2013-12-25 | 2015-07-02 | 株式会社日立ハイテクノロジーズ | Automatic analysis device and analysis method |
JP5916176B2 (en) * | 2014-03-11 | 2016-05-11 | 大日本印刷株式会社 | Microbial contaminant concentration detection method, electrode chip and oligopeptide |
CN105259227B (en) * | 2015-11-10 | 2017-10-17 | 华东交通大学 | A kind of blood coagulation enzyme assay method of molecular imprinting electrochemical sensor |
JP6895139B2 (en) * | 2016-02-16 | 2021-06-30 | 生化学工業株式会社 | Electrochemical measurement using a phenylenediamine derivative |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0018002B1 (en) * | 1979-04-24 | 1983-02-09 | Marcel Jozefonvicz | Process for the determination of proteases and antiproteases |
US6150174A (en) * | 1997-03-05 | 2000-11-21 | Diametrics Medical, Inc. | Method for measurement of whole blood coagulation parameters |
DE69941563D1 (en) * | 1999-02-23 | 2009-12-03 | Asulab Sa | Electrochemical system for the determination of blood clotting time |
-
2001
- 2001-02-19 EP EP01905800A patent/EP1261861B1/en not_active Expired - Lifetime
- 2001-02-19 CA CA002400651A patent/CA2400651A1/en not_active Abandoned
- 2001-02-19 WO PCT/EP2001/001848 patent/WO2001063271A1/en active IP Right Grant
- 2001-02-19 AU AU2001233785A patent/AU2001233785A1/en not_active Abandoned
- 2001-02-19 AT AT01905800T patent/ATE278186T1/en not_active IP Right Cessation
- 2001-02-19 JP JP2001562186A patent/JP2003524184A/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
ATE278186T1 (en) | 2004-10-15 |
CA2400651A1 (en) | 2001-08-30 |
EP1261861A1 (en) | 2002-12-04 |
WO2001063271A1 (en) | 2001-08-30 |
EP1261861B1 (en) | 2004-09-29 |
JP2003524184A (en) | 2003-08-12 |
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