AU1939188A - Ascorbic acid intermediates and process enzymes - Google Patents

Ascorbic acid intermediates and process enzymes

Info

Publication number
AU1939188A
AU1939188A AU19391/88A AU1939188A AU1939188A AU 1939188 A AU1939188 A AU 1939188A AU 19391/88 A AU19391/88 A AU 19391/88A AU 1939188 A AU1939188 A AU 1939188A AU 1939188 A AU1939188 A AU 1939188A
Authority
AU
Australia
Prior art keywords
ascorbic acid
acid intermediates
process enzymes
enzymes
intermediates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU19391/88A
Other versions
AU612672B2 (en
Inventor
Stephen Anderson
David S. Light
Cara Marks
William E. Rastetter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of AU1939188A publication Critical patent/AU1939188A/en
Application granted granted Critical
Publication of AU612672B2 publication Critical patent/AU612672B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01274—2,5-Didehydrogluconate reductase (1.1.1.274), i.e. 2,5-diketo-D-gluconic acid reductase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/58—Aldonic, ketoaldonic or saccharic acids
    • C12P7/60—2-Ketogulonic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/823—Acetobacter
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/843—Corynebacterium
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/847—Erwinia
AU19391/88A 1987-05-21 1988-05-19 Ascorbic acid intermediates and process enzymes Ceased AU612672B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/053,290 US5008193A (en) 1984-06-14 1987-05-21 Ascorbic acid intermediates and process enzymes
US053290 1987-05-21

Publications (2)

Publication Number Publication Date
AU1939188A true AU1939188A (en) 1988-12-21
AU612672B2 AU612672B2 (en) 1991-07-18

Family

ID=21983193

Family Applications (1)

Application Number Title Priority Date Filing Date
AU19391/88A Ceased AU612672B2 (en) 1987-05-21 1988-05-19 Ascorbic acid intermediates and process enzymes

Country Status (4)

Country Link
US (1) US5008193A (en)
EP (1) EP0292303A1 (en)
AU (1) AU612672B2 (en)
WO (1) WO1988009377A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE68924761T2 (en) * 1988-01-14 1996-04-04 Hoffmann La Roche NEW COENZYME INDEPENDENT L-SORBOSONE DEHYDROGENASE.
US5399496A (en) * 1989-02-02 1995-03-21 Hoffman-Laroche Inc. DNA shuttle vectors for E. coli, Gluconobacter, and Acetobacter
DE69014657T2 (en) * 1989-02-02 1995-05-11 Hoffmann La Roche Pendulum vectors, usable for the microorganisms belonging to the Escherichia coli, Gluconobacter and Acetobacter.
US5376544A (en) * 1992-09-08 1994-12-27 Rutgers The State University Of New Jersey Enzymes for the production of 2-keto-L-gulonic acid
US5795761A (en) * 1996-01-11 1998-08-18 Rutgers, The State University Of New Jersey Mutants of 2,5-diketo-D-gluconic acid (2,5-DKG) reductase A
US5817490A (en) * 1996-05-17 1998-10-06 Eastman Chemical Company Enzymatic process for the manufacture of ascorbic acid 2-keto-L-gulonic acid and esters of 2-keto-L-gulonic acid
US6916646B1 (en) * 1997-06-23 2005-07-12 Genencor International, Inc. Enterobacteriaceae fermentation strains
KR100257117B1 (en) * 1997-09-25 2000-05-15 박호군 Membrane-bound gluconate dehydrogenase, gene sequence coding therefor, and production of 2-keto-D-gluconate using transformed recombinant E-coli
US6599722B2 (en) * 1998-12-22 2003-07-29 Genencor International, Inc. Method for producing ascorbic acid intermediates
US6423518B1 (en) 2000-09-11 2002-07-23 Rutgers, The State University Design and production of mutant 2,5-diketo-D-gluconic acid reductase enzymes with altered cofactor dependency
EP1383903B1 (en) 2001-04-04 2008-09-24 Genencor International, Inc. Methods for the production of ascorbic acid intermediates in host cells
ATE421577T1 (en) 2001-04-04 2009-02-15 Genencor Int UNCOUPLED ANABOLIC AND CATABOLIC METABOLIC PATHWAYS IN HOST CELLS
DE60208582T2 (en) * 2001-11-09 2006-11-09 Dsm Ip Assets B.V. ENZYMATIC PROCESS FOR THE PREPARATION OF L-ASCORBIC ACID AND D-ERYTHORBIC ACID
US20040086984A1 (en) * 2002-10-31 2004-05-06 Kado Clarence I. Microbiological method for producing ascorbic acid
DK1625211T3 (en) * 2003-05-22 2015-02-23 Danisco Us Inc Metabolic MANIPULATED BACTERIA STRAINS THAT ARE NON-FUNCTIONAL endogenous GLUCONATTRANSPORTERE
CA2533938C (en) 2003-07-30 2013-09-10 Genencor International, Inc. Multimeric oxidoreductases
CN1829800B (en) * 2003-07-30 2010-06-09 金克克国际有限公司 Metabolically engineered bacterial strains having enhanced 2-keto-D-gluconate accumulation

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3790444A (en) * 1971-03-09 1974-02-05 Daiichi Seiyaku Co Process for preparing diketogluconic acid
US3907639A (en) * 1972-08-31 1975-09-23 Hoffmann La Roche Method for producing 2-keto-L-gulonic acid
US4263402A (en) * 1979-09-28 1981-04-21 Pfizer Inc. Process for producing 2,5-diketogluconic
US4316960A (en) * 1979-09-28 1982-02-23 Pfizer Inc. Preparation of 2,5-diketogluconic acid
US4245049A (en) * 1980-01-21 1981-01-13 Pfizer Inc. Preparation of 2-keto-L-gulonic acid
JPS6041596B2 (en) * 1980-08-14 1985-09-18 塩野義製薬株式会社 Method for producing 2,5-diketo-D-gluconic acid
JPS58162298A (en) * 1982-03-05 1983-09-26 Shionogi & Co Ltd Preparation of 2-keto-l-gulonic acid
US4543331A (en) * 1982-03-05 1985-09-24 Shionogi & Co., Ltd. Fermentative or enzymatic production of 2-keto-L-gulonic acid
US4758514A (en) * 1983-06-28 1988-07-19 Genentech, Inc. Ascorbic acid intermediates and process enzymes
US4757012A (en) * 1983-06-28 1988-07-12 Genentech, Inc. Ascorbic acid intermediates and process enzymes
IL89242A (en) * 1983-06-28 1990-08-31 Genentech Inc Process for producing a recombinant microorganism capable of converting glucose into 2-keto-l-gulonic acid,the microorganism obtained by said process and its use in converting glucose into 2-keto-l-gulonic acid
AU594080B2 (en) * 1985-08-02 1990-03-01 Genencor International, Inc. Production of a vitamin c precursor using genetically modified organisms

Also Published As

Publication number Publication date
WO1988009377A1 (en) 1988-12-01
EP0292303A1 (en) 1988-11-23
US5008193A (en) 1991-04-16
AU612672B2 (en) 1991-07-18

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired