AU1935399A - Nucleotide and protein sequence of mammastatin and methods of use - Google Patents
Nucleotide and protein sequence of mammastatin and methods of useInfo
- Publication number
- AU1935399A AU1935399A AU19353/99A AU1935399A AU1935399A AU 1935399 A AU1935399 A AU 1935399A AU 19353/99 A AU19353/99 A AU 19353/99A AU 1935399 A AU1935399 A AU 1935399A AU 1935399 A AU1935399 A AU 1935399A
- Authority
- AU
- Australia
- Prior art keywords
- mammastatin
- kda
- phosphorylated
- mammary
- express
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57415—Specifically defined cancers of breast
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Pathology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Hospice & Palliative Care (AREA)
- Biotechnology (AREA)
- Oncology (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Wood Science & Technology (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A nucleic acid sequence encoding Mammastatin, a specific mammary cell growth inhibitor. Mammastatin is encoded by a single nucleic acid sequence and has an approximate molecular weight of 44 kDa in its inactive, non-phosphorylated form. Normal mammary cells express functional phosphorylated forms having approximate molecular weights of 53 kDa and 49 kDa. Metastatic mammary cells either do not express Mammastatin at all, or do not express the 53 kDa or 49 kDa, phosphorylated forms. Mammary cancer cells are inhibited in their growth by the administration of phosphorylated mammastatin.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/994,076 US6500937B1 (en) | 1996-10-03 | 1997-12-19 | Nucleotide sequence encoding a mammary cell growth inhibitor |
US08994076 | 1997-12-19 | ||
PCT/US1998/027147 WO1999032625A2 (en) | 1997-12-19 | 1998-12-18 | Nucleotide and protein sequence of mammastatin and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
AU1935399A true AU1935399A (en) | 1999-07-12 |
Family
ID=25540260
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU19353/99A Abandoned AU1935399A (en) | 1997-12-19 | 1998-12-18 | Nucleotide and protein sequence of mammastatin and methods of use |
Country Status (8)
Country | Link |
---|---|
US (5) | US6500937B1 (en) |
EP (1) | EP1037989B1 (en) |
JP (1) | JP4441113B2 (en) |
AT (1) | ATE364706T1 (en) |
AU (1) | AU1935399A (en) |
CA (1) | CA2315239C (en) |
DE (1) | DE69837935T2 (en) |
WO (1) | WO1999032625A2 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6500937B1 (en) * | 1996-10-03 | 2002-12-31 | University Of Michigan | Nucleotide sequence encoding a mammary cell growth inhibitor |
CA2267095C (en) * | 1996-10-03 | 2010-08-10 | Biotherapies, Inc. | Nucleotide and protein sequence of mammastatin and methods of use |
BR0012301A (en) * | 1999-06-18 | 2002-03-26 | Biotherapies Inc | Epithelial cell growth inhibitors |
US6939714B2 (en) | 1999-06-18 | 2005-09-06 | Biotherapies, Inc. | Epithelial cell growth inhibitors |
AU6583700A (en) * | 1999-08-13 | 2001-03-13 | Oxford Glycosciences (Uk) Limited | Proteins, genes and their use for diagnosis and treatment of breast cancer |
AU2596901A (en) * | 1999-12-21 | 2001-07-03 | Millennium Pharmaceuticals, Inc. | Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer |
WO2001071357A2 (en) * | 2000-03-20 | 2001-09-27 | Oxford Glycosciences (Uk) Limited | Diagnosis and treatment of breast cancer |
US20030212263A1 (en) * | 2000-06-19 | 2003-11-13 | The University Of Michigan | Mammastatin sequence variant C |
WO2002088750A2 (en) * | 2001-05-02 | 2002-11-07 | Oxford Glycosciences (Uk) Ltd | Proteins, genes and their use for diagnosis and treatment of breast cancer |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4379839A (en) | 1977-05-23 | 1983-04-12 | The Trustees Of Columbia University In The City Of New York | Method for detecting cancer |
US4753894A (en) | 1984-02-08 | 1988-06-28 | Cetus Corporation | Monoclonal anti-human breast cancer antibodies |
WO1989011492A1 (en) | 1988-05-20 | 1989-11-30 | The Regents Of The University Of Michigan | Human mammary cell growth inhibitor and methods of production and use |
WO1989011491A1 (en) | 1988-05-20 | 1989-11-30 | The Regents Of The University Of Michigan | Antibodies to human mammary cell growth inhibitor and methods of production and use |
US5878385A (en) * | 1996-09-16 | 1999-03-02 | Ergo Linguistic Technologies | Method and apparatus for universal parsing of language |
US6500937B1 (en) * | 1996-10-03 | 2002-12-31 | University Of Michigan | Nucleotide sequence encoding a mammary cell growth inhibitor |
CA2267095C (en) * | 1996-10-03 | 2010-08-10 | Biotherapies, Inc. | Nucleotide and protein sequence of mammastatin and methods of use |
BR0012301A (en) | 1999-06-18 | 2002-03-26 | Biotherapies Inc | Epithelial cell growth inhibitors |
-
1997
- 1997-12-19 US US08/994,076 patent/US6500937B1/en not_active Expired - Fee Related
-
1998
- 1998-12-18 AT AT98964170T patent/ATE364706T1/en not_active IP Right Cessation
- 1998-12-18 AU AU19353/99A patent/AU1935399A/en not_active Abandoned
- 1998-12-18 EP EP98964170A patent/EP1037989B1/en not_active Expired - Lifetime
- 1998-12-18 JP JP2000525544A patent/JP4441113B2/en not_active Expired - Fee Related
- 1998-12-18 DE DE69837935T patent/DE69837935T2/en not_active Expired - Lifetime
- 1998-12-18 CA CA002315239A patent/CA2315239C/en not_active Expired - Fee Related
- 1998-12-18 WO PCT/US1998/027147 patent/WO1999032625A2/en active IP Right Grant
-
2000
- 2000-08-22 US US09/643,476 patent/US6599495B1/en not_active Expired - Fee Related
-
2003
- 2003-06-11 US US10/459,218 patent/US7256277B2/en not_active Expired - Fee Related
-
2007
- 2007-08-14 US US11/838,654 patent/US7816097B2/en not_active Expired - Fee Related
-
2010
- 2010-07-29 US US12/846,386 patent/US20110003318A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US7256277B2 (en) | 2007-08-14 |
JP2001526891A (en) | 2001-12-25 |
EP1037989A2 (en) | 2000-09-27 |
US20080207506A1 (en) | 2008-08-28 |
US7816097B2 (en) | 2010-10-19 |
EP1037989B1 (en) | 2007-06-13 |
WO1999032625A3 (en) | 1999-09-16 |
WO1999032625A2 (en) | 1999-07-01 |
JP4441113B2 (en) | 2010-03-31 |
ATE364706T1 (en) | 2007-07-15 |
US6599495B1 (en) | 2003-07-29 |
US6500937B1 (en) | 2002-12-31 |
DE69837935T2 (en) | 2008-02-21 |
US20110003318A1 (en) | 2011-01-06 |
CA2315239A1 (en) | 1999-07-01 |
US20070082334A1 (en) | 2007-04-12 |
CA2315239C (en) | 2008-05-13 |
DE69837935D1 (en) | 2007-07-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |