AU1752792A - Multicyclic tertiary amine polyaromatic squalene synthetase inhibitors - Google Patents

Multicyclic tertiary amine polyaromatic squalene synthetase inhibitors

Info

Publication number
AU1752792A
AU1752792A AU17527/92A AU1752792A AU1752792A AU 1752792 A AU1752792 A AU 1752792A AU 17527/92 A AU17527/92 A AU 17527/92A AU 1752792 A AU1752792 A AU 1752792A AU 1752792 A AU1752792 A AU 1752792A
Authority
AU
Australia
Prior art keywords
tertiary amine
synthetase inhibitors
squalene synthetase
multicyclic
amine polyaromatic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU17527/92A
Inventor
Dilip Amin
Robert L Morris
Kent Neuenschwander
Anthony C. Scotese
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Rorer International Holdings Inc
Original Assignee
Rhone Poulenc Rorer International Holdings Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer International Holdings Inc filed Critical Rhone Poulenc Rorer International Holdings Inc
Publication of AU1752792A publication Critical patent/AU1752792A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU17527/92A 1991-03-08 1992-03-03 Multicyclic tertiary amine polyaromatic squalene synthetase inhibitors Abandoned AU1752792A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66768691A 1991-03-08 1991-03-08
US667686 1991-03-08

Publications (1)

Publication Number Publication Date
AU1752792A true AU1752792A (en) 1992-10-06

Family

ID=24679220

Family Applications (1)

Application Number Title Priority Date Filing Date
AU17527/92A Abandoned AU1752792A (en) 1991-03-08 1992-03-03 Multicyclic tertiary amine polyaromatic squalene synthetase inhibitors

Country Status (5)

Country Link
JP (1) JPH06506467A (en)
AU (1) AU1752792A (en)
CA (1) CA2105655A1 (en)
MX (1) MX9201030A (en)
WO (1) WO1992015579A1 (en)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9122988D0 (en) * 1991-10-30 1991-12-18 Ici Plc Heterocyclic compounds
GB9127279D0 (en) * 1991-12-23 1992-02-19 Ici Plc Heterocyclic derivatives
GB9201749D0 (en) * 1992-01-28 1992-03-11 Smithkline Beecham Plc Medicaments
US5726306A (en) * 1992-04-20 1998-03-10 Takeda Chemical Industries, Ltd. 4,1-benzoxazepin derivatives and their use
GB9207961D0 (en) * 1992-04-10 1992-05-27 Ici Plc Heterocyclic derivatives
JPH06508377A (en) * 1992-04-10 1994-09-22 ゼネカ　リミテッド heterocyclic compound
SG82630A1 (en) * 1992-04-20 2001-08-21 Takeda Chemical Industries Ltd 4,1-benzoxazepin derivatives and their use
GB9211796D0 (en) * 1992-06-04 1992-07-15 Ici Plc Heterocyclic derivatives
GB9216721D0 (en) * 1992-08-06 1992-09-23 Ici Plc Therapeutic heterocyclic derivatives
GB9218334D0 (en) * 1992-08-28 1992-10-14 Ici Plc Heterocyclic compounds
GB9226577D0 (en) * 1992-12-21 1993-02-17 Ici Plc Heterocyclic derivatives
GB9226573D0 (en) * 1992-12-21 1993-02-17 Ici Plc Heterocyclic compounds
JPH08504801A (en) * 1992-12-21 1996-05-28 ゼネカ・リミテッド Quinuclidine derivatives as squalene synthase inhibitors
US5451596A (en) * 1992-12-29 1995-09-19 Rhone Poulenc Rorer Pharmaceuticals Inc. Cycloalkyl amine bis-aryl squalene synthase inhibitors
CA2115183A1 (en) * 1993-02-12 1994-08-13 Takashi Nomoto Substituted amic acid derivatives
IL109451A0 (en) * 1993-04-29 1994-07-31 Zeneca Ltd Heterocyclic derivatives
AU678503B2 (en) * 1993-09-24 1997-05-29 Takeda Chemical Industries Ltd. Condensed heterocyclic compounds and their use as squalene synthetase inhibitors
GB9412145D0 (en) * 1994-06-17 1994-08-10 Zeneca Ltd Heterocycles
US5556990A (en) * 1994-12-16 1996-09-17 Rhone-Poulenc Rorer Pharmaceuticals Inc. Polyarylcarbamoylaza- and -carbamoylalkanedioic acids
US6297198B1 (en) 1996-05-14 2001-10-02 Syngenta Participations Ag Isoxazole derivatives and their use as herbicides
SE9902987D0 (en) 1999-08-24 1999-08-24 Astra Pharma Prod Novel compounds
DE60024651T2 (en) 1999-09-28 2006-09-28 Eisai Co., Ltd. CHINUCLIDIN COMPOUNDS AND MEDICAMENTS CONTAINING THESE AS ACTIVE ACTIVE SUBSTANCES
AU2001282874A1 (en) 2000-08-18 2002-03-04 Pharmacia And Upjohn Company Quinuclidine-substituted aryl moieties for treatment of disease (nicotinic acetylcholine receptor ligands)
US6492385B2 (en) 2000-08-18 2002-12-10 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease
AU2001282873A1 (en) 2000-08-18 2002-03-04 Pharmacia And Upjohn Company Quinuclidine-substituted aryl compounds for treatment of disease
US6599916B2 (en) 2000-08-21 2003-07-29 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease
US6500840B2 (en) 2000-08-21 2002-12-31 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease
GB0104050D0 (en) 2001-02-19 2001-04-04 Astrazeneca Ab Chemical compounds
GB0107228D0 (en) 2001-03-22 2001-05-16 Astrazeneca Ab Chemical compounds
WO2002076973A1 (en) 2001-03-27 2002-10-03 Eisai Co., Ltd. N-aryl-substituted cyclic amine derivative and medicine containing the same as active ingredient
PE20021019A1 (en) 2001-04-19 2002-11-13 Upjohn Co SUBSTITUTED AZABYCLE GROUPS
JP2005504058A (en) 2001-08-24 2005-02-10 ファルマシア アンド アップジョン カンパニー リミティド ライアビリティー カンパニー Substituted heteroaryl-7-aza [2.2.1] bicycloheptane for the treatment of disease
EP1442041A1 (en) 2001-11-08 2004-08-04 PHARMACIA & UPJOHN COMPANY Azabicyclic-substituted-heteroaryl compounds for the treatment of disease
SE0103818D0 (en) 2001-11-15 2001-11-15 Astrazeneca Ab Chemical compounds
CA2476417A1 (en) 2002-02-15 2003-08-28 Pharmacia & Upjohn Company Azabicyclo-substituted benzoylamides and thioamides for treatment of cns-related disorders
WO2004013137A1 (en) 2002-08-01 2004-02-12 Pharmacia & Upjohn Company Llc 1h-pyrazole and 1h-pyrrole-azabicyclic compounds with alfa-7 nachr activity
GB0220581D0 (en) 2002-09-04 2002-10-09 Novartis Ag Organic Compound
SE0301369D0 (en) 2003-05-09 2003-05-09 Astrazeneca Ab Chemical compounds
DE10334724A1 (en) * 2003-07-30 2005-02-24 Bayer Healthcare Ag N-biaryl
US7655657B2 (en) 2003-12-22 2010-02-02 Abbott Laboratories Fused bicycloheterocycle substituted quinuclidine derivatives
WO2006065233A1 (en) * 2004-12-10 2006-06-22 Abbott Laboratories Fused bicycloheterocycle substituted quinuclidine derivatives
US7160876B2 (en) 2003-12-22 2007-01-09 Abbott Laboratories Fused bicycloheterocycle substituted quinuclidine derivatives
US20050245531A1 (en) * 2003-12-22 2005-11-03 Abbott Laboratories Fused bicycloheterocycle substituted quinuclidine derivatives
AR049401A1 (en) 2004-06-18 2006-07-26 Novartis Ag AZA-BICICLONONANS
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
GB0415746D0 (en) 2004-07-14 2004-08-18 Novartis Ag Organic compounds
GB0611907D0 (en) 2006-06-15 2006-07-26 Glaxo Group Ltd Compounds
US7297704B2 (en) 2005-02-17 2007-11-20 Wyeth Cycloalkyfused indole, benzothiophene, benzofuran and idene derivatives
GB0521508D0 (en) 2005-10-21 2005-11-30 Novartis Ag Organic compounds
GB0525672D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
GB0525673D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
US8314119B2 (en) 2006-11-06 2012-11-20 Abbvie Inc. Azaadamantane derivatives and methods of use
SG188307A1 (en) 2010-09-23 2013-04-30 Abbvie Inc Monohydrate of an azaadamantane derivative
US20170298081A1 (en) * 2014-08-08 2017-10-19 Kasuma Partners Inc. Condensed heterocyclic compound
CO2018009534A2 (en) * 2016-02-15 2018-09-20 Sanofi Sa New 6,7-dihydro-5h-benzo [7] substituted anulene compounds, processes for their preparation and therapeutic uses thereof
EP3541809A1 (en) 2016-11-17 2019-09-25 Sanofi Novel substituted n-(3-fluoropropyl)-pyrrolidine compounds, processes for their preparation and therapeutic uses thereof
EP3434272A1 (en) 2017-07-25 2019-01-30 Sanofi Combination comprising palbociclib and 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylic acid
MX2021002665A (en) 2018-09-07 2021-07-16 Sanofi Sa Salts of methyl 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoroprop yl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2- carboxylate and preparation process thereof.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH667657A5 (en) * 1985-01-07 1988-10-31 Sandoz Ag CARBOCYCLIC AND HETEROCYCLIC CARBONYL METHYLENE AND METHYL PIPERIDINE AND PYRROLIDINE.

Also Published As

Publication number Publication date
CA2105655A1 (en) 1992-09-09
JPH06506467A (en) 1994-07-21
MX9201030A (en) 1992-09-01
WO1992015579A1 (en) 1992-09-17

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