AU1598799A - Use of substituted 11-phenyl-dibenzazepine compounds for the treatment or prevention of sickle cell disease, inflammatory diseases characterized by abnormal cell proliferation, diarrhea and scour - Google Patents

Use of substituted 11-phenyl-dibenzazepine compounds for the treatment or prevention of sickle cell disease, inflammatory diseases characterized by abnormal cell proliferation, diarrhea and scour Download PDF

Info

Publication number
AU1598799A
AU1598799A AU15987/99A AU1598799A AU1598799A AU 1598799 A AU1598799 A AU 1598799A AU 15987/99 A AU15987/99 A AU 15987/99A AU 1598799 A AU1598799 A AU 1598799A AU 1598799 A AU1598799 A AU 1598799A
Authority
AU
Australia
Prior art keywords
group
aryl
halogen
compounds
trihalomethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU15987/99A
Other languages
English (en)
Inventor
Seth Alper
Emile M. Bellot Jr.
Carlo Brugnara
John J. Clifford
Mark Froimowitz
Ying-Duo Gao
Reem M. Haidar
Jose Halperin
Eugene W. Kelleher
Falguni M. Kher
Wayne I. Lencer
Richard John Lombardy
Adel M. Moussa
Yesh P Sachdeva
Minghua Sun
Heather N. Taft
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harvard College
Childrens Medical Center Corp
Original Assignee
Harvard College
Childrens Medical Center Corp
Ion Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/159,333 external-priority patent/US6291449B1/en
Priority claimed from US09/159,337 external-priority patent/US20030134842A1/en
Application filed by Harvard College, Childrens Medical Center Corp, Ion Pharmaceuticals Inc filed Critical Harvard College
Publication of AU1598799A publication Critical patent/AU1598799A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/20—Dibenz [b, e] azepines; Hydrogenated dibenz [b, e] azepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
AU15987/99A 1997-11-20 1998-11-20 Use of substituted 11-phenyl-dibenzazepine compounds for the treatment or prevention of sickle cell disease, inflammatory diseases characterized by abnormal cell proliferation, diarrhea and scour Abandoned AU1598799A (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US97559497A 1997-11-20 1997-11-20
US08975594 1997-11-20
US09159337 1998-09-23
US09/159,333 US6291449B1 (en) 1998-09-23 1998-09-23 Use of 11-phenyl-dibenzazepine compounds to treat diarrhea or scours
US09/159,337 US20030134842A1 (en) 1997-11-20 1998-09-23 Methods for the treatment or prevention of inflammatory diseases characterized by abnormal cell proliferation
US09159333 1998-09-23
PCT/US1998/024967 WO1999026628A1 (fr) 1997-11-20 1998-11-20 Utilisation de composes 11-phenyl-dibenzazepine substitues dans le traitement ou la prevention de la drepanocytose, des maladies inflammatoires caracterisees par une proliferation cellulaire anormale et par la diarrhee chez l'homme et l'animal

Publications (1)

Publication Number Publication Date
AU1598799A true AU1598799A (en) 1999-06-15

Family

ID=27388303

Family Applications (1)

Application Number Title Priority Date Filing Date
AU15987/99A Abandoned AU1598799A (en) 1997-11-20 1998-11-20 Use of substituted 11-phenyl-dibenzazepine compounds for the treatment or prevention of sickle cell disease, inflammatory diseases characterized by abnormal cell proliferation, diarrhea and scour

Country Status (6)

Country Link
EP (1) EP1032394A1 (fr)
JP (1) JP2001523720A (fr)
AU (1) AU1598799A (fr)
CA (1) CA2310773A1 (fr)
IL (1) IL136209A0 (fr)
WO (1) WO1999026628A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6291449B1 (en) 1998-09-23 2001-09-18 Children's Medical Center Corporation Use of 11-phenyl-dibenzazepine compounds to treat diarrhea or scours
KR20040106298A (ko) * 2002-03-21 2004-12-17 아나디스 리미티드 불안정한 생활성 물질 및 포유동물 초유를 포함한 조성물,제조 및 치료 방법
AU2003212098B2 (en) * 2002-03-21 2008-07-24 Anadis Ltd Compositions containing labile bioactive materials and mammalian colostrum, methods of preparation and treatment
CN116847838A (zh) 2020-12-11 2023-10-03 桑昆专利有限公司 炎症性贫血的治疗和预防

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5273992A (en) * 1992-11-02 1993-12-28 Beth Israel Hospital Assoc. Inc. Method for reducing sickle erythrocyte dehydration and delaying the occurrence of erythrocyte sickling in-situ
EP0781128B1 (fr) * 1994-09-16 2005-11-23 Children's Medical Center Corporation Metabolites de clotrimazole contre la drepanocytose

Also Published As

Publication number Publication date
JP2001523720A (ja) 2001-11-27
CA2310773A1 (fr) 1999-06-03
EP1032394A1 (fr) 2000-09-06
IL136209A0 (en) 2001-05-20
WO1999026628A1 (fr) 1999-06-03

Similar Documents

Publication Publication Date Title
US6331564B1 (en) Use of triaryl methane compounds for inhibiting unwanted cellular proliferation associated with inflammatory disease
US6495567B1 (en) Triaryl methane compounds and their use in the treatment of diarrhea and scours
US6028103A (en) Triaryl methane compounds and analogues thereof useful for the treatment or prevention of sickle cell disease or diseases characterized by abnormal cell proliferation
JP2008201783A (ja) 鎌状赤血球症のためのトリアリールメタン化合物
AU1598799A (en) Use of substituted 11-phenyl-dibenzazepine compounds for the treatment or prevention of sickle cell disease, inflammatory diseases characterized by abnormal cell proliferation, diarrhea and scour
AU1598899A (en) Use of substituted diphenyl indanone, indane and indole compounds for the treatment or prevention of sickle cell disease, inflammatory diseases characterized by abnormal cell proliferation, diarrhe and scours
JP3790425B2 (ja) 異常な細胞増殖を特徴とする病気を治療および予防するための置換１１−フェニル−ジベンズアゼピン化合物
US20020128256A1 (en) Methods for the treatment or prevention of inflammatory diseases characterized by abnormal cell proliferation
US6800658B2 (en) Substituted diphenyl indanone, indane and indole compounds and analogues thereof useful for the treatment of prevention of diseases characterized by abnormal cell proliferation
US20030134842A1 (en) Methods for the treatment or prevention of inflammatory diseases characterized by abnormal cell proliferation
ES2221237T3 (es) Compuestos sustituidos de difenil-indanona, indano e indol y sus analogos, utiles en el tratamiento o prevencion de enfermedades caracterizadas por proliferacion celular anormal.
US6291449B1 (en) Use of 11-phenyl-dibenzazepine compounds to treat diarrhea or scours
US6992079B2 (en) Substituted 11-phenyl-dibenzazepine compounds useful for the treatment or prevention of diseases characterized by abnormal cell proliferation
US20020004519A1 (en) Method for reducing chloride secetion by intestinal epithlial cells in situ
AU2640201A (en) Triaryl and diaryl compounds, their analogues and uses thereof

Legal Events

Date Code Title Description
MK4 Application lapsed section 142(2)(d) - no continuation fee paid for the application