AU1368392A - Use of oxazolo-(2,3-a)isoindole and imidazo(2,1-a)isoindole derivatives as antiviral drugs, and new oxazolo(2,3-a)isoindole derivatives - Google Patents
Use of oxazolo-(2,3-a)isoindole and imidazo(2,1-a)isoindole derivatives as antiviral drugs, and new oxazolo(2,3-a)isoindole derivativesInfo
- Publication number
- AU1368392A AU1368392A AU13683/92A AU1368392A AU1368392A AU 1368392 A AU1368392 A AU 1368392A AU 13683/92 A AU13683/92 A AU 13683/92A AU 1368392 A AU1368392 A AU 1368392A AU 1368392 A AU1368392 A AU 1368392A
- Authority
- AU
- Australia
- Prior art keywords
- isoindole
- oxazolo
- derivatives
- residue
- antiviral drugs
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
The invention concerns the use of oxazolo-[2,3-a]isoindole and iminazo[2,1-a]isoindole derivatives as antiviral drugs, as well as optically active derivatives, new oxazolo-[2,3-a]isoindole derivatives, a method for preparing them and drugs containing these compounds. In particular, the subject matter of the invention is the use of oxazolo-[2,3-a]isoindole and imidazo[2,1-a]isoindole derivatives of general formula (I) to produce antiviral drugs. In formula (I), X stands for an oxygen atom or a sulphur atom, the imino group =NH or a =N-C1?-C5? alkylimino group, Y stands for an oxygen atom or the group NR?7, wherein R?7 is a hydrogen atom or a C1?-C6? alkyl residue or a C1?-C6? acyl residue, R is a hydrogen atom, a straight-chain or branched, saturated or unsaturated aliphataic residue containing 1-9 carbon atoms, possibly substituted by phenyl, or a phenyl ring possibly substituted one or more times, or a carbocyclic or heterocyclic ring, R?1 and R?2 stand for a hydrogen atom, a straight-chain or branched, saturated or unsaturated aliphatic residue with 1 to 6 carbon atoms, R?3-R?6 stand for hydrogen, C1?-C6? alkyl, C1?-C6? alkoxy, C1?-C6? alkylmercapto, amino, C1?-C6? alkylamino, di-C1?-C6? alkylamino, halogen, cyano, hydroxy, carboxy, aminocarbonyl, substituted aminocarbonyl or C1?-C6? alkoxycarbonyl. The invention also concerns their tautomers, enantiomers, diastereomers and physiologically acceptable salts.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4108395A DE4108395A1 (en) | 1991-03-15 | 1991-03-15 | USE OF OXAZOLO- (2,3-A) ISOINDOL AND IMIDAZO (2,1-A) ISOINDOL DERIVATIVES AS ANTIVIRAL MEDICAMENTS AND NEW OXAZOLO (2,3-A) ISOINDOL DERIVATIVES |
DE4108395 | 1991-03-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
AU1368392A true AU1368392A (en) | 1992-10-21 |
Family
ID=6427351
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU13683/92A Abandoned AU1368392A (en) | 1991-03-15 | 1992-03-13 | Use of oxazolo-(2,3-a)isoindole and imidazo(2,1-a)isoindole derivatives as antiviral drugs, and new oxazolo(2,3-a)isoindole derivatives |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0575425B1 (en) |
JP (1) | JPH06507388A (en) |
AT (1) | ATE128868T1 (en) |
AU (1) | AU1368392A (en) |
CA (1) | CA2108899A1 (en) |
DE (2) | DE4108395A1 (en) |
WO (1) | WO1992016207A1 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4214829A1 (en) * | 1992-05-10 | 1993-11-11 | Boehringer Mannheim Gmbh | Use of tricyclic pyrimidine derivatives as antiviral drugs |
DE4311782A1 (en) * | 1993-04-09 | 1994-10-13 | Boehringer Mannheim Gmbh | Indazole derivatives and medicines containing them |
US6608098B1 (en) | 1999-08-25 | 2003-08-19 | Banyu Pharmaceutical Co., Ltd. | Isoindole derivatives |
WO2002066479A1 (en) * | 2001-02-23 | 2002-08-29 | Banyu Pharmaceutical Co.,Ltd. | Novel isoindole derivatives |
KR20060127909A (en) * | 2003-12-24 | 2006-12-13 | 비오타 사이언티픽 매니지먼트 피티와이 엘티디 | Polycyclic agents for the treatment of respiratory syncytial virus infections |
TWI423972B (en) | 2006-09-28 | 2014-01-21 | Biota Scient Management | Polycyclic agents for the treatment of respiratory syncytial virus infections |
TWI508968B (en) | 2010-02-08 | 2015-11-21 | Biota Scient Management | Compounds for treating respiratory syncytial virus infections |
US8796303B2 (en) | 2010-11-26 | 2014-08-05 | Biota Scientific Management Pty Ltd. | Imidazo[2,1-G][1,7]naphthyridines for treating respiratory syncytial virus infections |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3334113A (en) * | 1963-12-18 | 1967-08-01 | Sandoz Ag | 9b-phenyl-1, 2, 3, 9b-tetrahydro-5h-imidazo[2,1-a]isoindol-5-ones |
US3336306A (en) * | 1965-10-22 | 1967-08-15 | American Home Prod | Oxazoloisoindolones and related compounds |
JPS59166502A (en) * | 1983-03-10 | 1984-09-19 | Daicel Chem Ind Ltd | Separating agent |
-
1991
- 1991-03-15 DE DE4108395A patent/DE4108395A1/en not_active Withdrawn
-
1992
- 1992-03-13 DE DE59204004T patent/DE59204004D1/en not_active Expired - Fee Related
- 1992-03-13 AU AU13683/92A patent/AU1368392A/en not_active Abandoned
- 1992-03-13 WO PCT/EP1992/000558 patent/WO1992016207A1/en active IP Right Grant
- 1992-03-13 CA CA002108899A patent/CA2108899A1/en not_active Abandoned
- 1992-03-13 JP JP4505814A patent/JPH06507388A/en active Pending
- 1992-03-13 AT AT92906522T patent/ATE128868T1/en not_active IP Right Cessation
- 1992-03-13 EP EP92906522A patent/EP0575425B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CA2108899A1 (en) | 1992-09-16 |
ATE128868T1 (en) | 1995-10-15 |
EP0575425A1 (en) | 1993-12-29 |
WO1992016207A1 (en) | 1992-10-01 |
EP0575425B1 (en) | 1995-10-11 |
JPH06507388A (en) | 1994-08-25 |
DE4108395A1 (en) | 1993-01-28 |
DE59204004D1 (en) | 1995-11-16 |
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