ATE88718T1 - Verfahren zur reinigung des hepatitis-oberflaechen-antigens und das so erhaltene produkt. - Google Patents
Verfahren zur reinigung des hepatitis-oberflaechen-antigens und das so erhaltene produkt.Info
- Publication number
- ATE88718T1 ATE88718T1 AT85304849T AT85304849T ATE88718T1 AT E88718 T1 ATE88718 T1 AT E88718T1 AT 85304849 T AT85304849 T AT 85304849T AT 85304849 T AT85304849 T AT 85304849T AT E88718 T1 ATE88718 T1 AT E88718T1
- Authority
- AT
- Austria
- Prior art keywords
- purification
- surface antigen
- product
- hepatitis surface
- hepatitis
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title abstract 2
- 102000036639 antigens Human genes 0.000 title abstract 2
- 108091007433 antigens Proteins 0.000 title abstract 2
- 208000006454 hepatitis Diseases 0.000 title abstract 2
- 231100000283 hepatitis Toxicity 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000000746 purification Methods 0.000 title abstract 2
- 239000003463 adsorbent Substances 0.000 abstract 1
- 238000005349 anion exchange Methods 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000001376 precipitating effect Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Detergent Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/629,295 US4624918A (en) | 1984-07-09 | 1984-07-09 | Purification process for hepatitis surface antigen and product thereof |
EP85304849A EP0168234B1 (de) | 1984-07-09 | 1985-07-08 | Verfahren zur Reinigung des Hepatitis-Oberflächen-Antigens und das so erhaltene Produkt |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE88718T1 true ATE88718T1 (de) | 1993-05-15 |
Family
ID=24522405
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT85304849T ATE88718T1 (de) | 1984-07-09 | 1985-07-08 | Verfahren zur reinigung des hepatitis-oberflaechen-antigens und das so erhaltene produkt. |
Country Status (5)
Country | Link |
---|---|
US (1) | US4624918A (de) |
EP (1) | EP0168234B1 (de) |
JP (1) | JPH0675B2 (de) |
AT (1) | ATE88718T1 (de) |
DE (1) | DE3587298T2 (de) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8597910B1 (en) | 1985-04-11 | 2013-12-03 | Children's Medical Center Corporation | DNA encoding Von Willebrand Factor (VWF) and methods and cells for producing VFW, and VFW produced by the DNA, methods and cells |
FR2608052B1 (fr) * | 1986-12-10 | 1990-04-13 | Pasteur Vaccins | Procede de preparation d'un vaccin contre l'hepatite b et vaccin obtenu |
US5026828A (en) * | 1987-02-27 | 1991-06-25 | Merck & Co., Inc. | Method of purifying recombinant pres-1/S-2/S/S hepatitis B antigen from yeast |
EP0294071A3 (de) * | 1987-06-03 | 1990-08-01 | Merck & Co. Inc. | Impfstoffe gegen Hepatitis B hergestellt mit vorherhergestellten Aluminiumhydroxydengelen und Verfahren zu deren Herstellung |
US5011915A (en) * | 1987-10-26 | 1991-04-30 | Merck & Co., Inc. | Process for purifying recombinant hepatitis antigens |
US5004688A (en) * | 1988-04-15 | 1991-04-02 | Phillips Petroleum Company | Purification of hepatitis proteins |
US5462863A (en) * | 1989-02-09 | 1995-10-31 | Development Center For Biotechnology | Isolation of Hepatitis B surface antigen from transformed yeast cells |
EP0384058A1 (de) * | 1989-02-09 | 1990-08-29 | Development Center For Biotechnology | Isolierung des Hepatitis-B-Oberflächenantigens von transformierten Hefezellen |
CU22290A1 (es) * | 1990-10-08 | 1995-01-31 | Cigb | Procedimiento para la obtencion de antigeno de superficie del virus de la hepatitis b de superior capacidad inmunoganica y su uso en un preparado vacunal |
IT1248075B (it) * | 1991-06-18 | 1995-01-05 | Sclavo Spa | Processo per la purificazione del virus dell'epatite a (hav), virus cosi` purificato e composizioni vaccinali che lo contengono. |
SK280702B6 (sk) * | 1992-05-23 | 2000-06-12 | Smithkline Beecham Biologicals S. A. | Kombinovaný očkovací prostriedok obsahujúci povrch |
US5709995A (en) | 1994-03-17 | 1998-01-20 | The Scripps Research Institute | Hepatitis C virus-derived peptides capable of inducing cytotoxic T lymphocyte responses |
IL118626A0 (en) | 1996-06-11 | 1996-10-16 | Xtl Biopharmaceuticals Limited | Anti HBV antibody |
US7998705B2 (en) * | 2002-08-06 | 2011-08-16 | FUJIFILM Diosynth Biotechnologies U.S.A., Inc | Increased dynamic binding capacity in ion exchange chromatography by addition of polyethylene glycol |
US9603921B2 (en) * | 2004-10-27 | 2017-03-28 | Janssen Vaccines Ag | Virosome particles comprising antigens from influenza virus and hepatitis b virus |
GB0522765D0 (en) * | 2005-11-08 | 2005-12-14 | Chiron Srl | Combination vaccine manufacture |
GB2495341B (en) | 2011-11-11 | 2013-09-18 | Novartis Ag | Fermentation methods and their products |
DE102011118371B4 (de) | 2011-11-11 | 2014-02-13 | Novartis Ag | Zur Impfung von Menschen geeignete Zusammensetzung, die ein Diphtherie-Toxoid umfasst, sowie Verfahren zu deren Herstellung |
DE102011122891B4 (de) | 2011-11-11 | 2014-12-24 | Novartis Ag | Fermentationsmedium, das frei von tierischen Bestandteilen ist, zur Herstellung von Diphtherie-Toxoiden zur Verwendung bei der Impfung von Menschen |
EP2592137A1 (de) | 2011-11-11 | 2013-05-15 | Novartis AG | Fermentierungsmedium ohne Bestandteile tierischen Ursprungs zur Herstellung von Diphtherie-Impfstoffen zur menschlichen Impfung |
MX2015004652A (es) | 2012-10-12 | 2015-08-05 | Glaxosmithkline Biolog Sa | Antigenos de pertusis acelulares no entrelazados para uso en vacunas de combinacion. |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3994870A (en) * | 1974-01-31 | 1976-11-30 | The Community Blood Council Of Greater New York, Inc. | Purification of hepatitis B surface antigen |
US4186193A (en) * | 1975-06-16 | 1980-01-29 | Merck & Co., Inc. | Hepatitis B antigen |
JPS5840930B2 (ja) * | 1976-09-20 | 1983-09-08 | 株式会社ミドリ十字 | B型肝炎ワクチンの製造方法 |
US4088748A (en) * | 1976-11-02 | 1978-05-09 | Merck & Co., Inc. | Hepatitis B surface antigen |
US4162192A (en) * | 1978-09-28 | 1979-07-24 | Juridical Foundation | Method for purification of HBs antigen |
US4181713A (en) * | 1978-10-30 | 1980-01-01 | Merck & Co., Inc. | Isolation of HBs Ag |
US4271145A (en) * | 1979-10-22 | 1981-06-02 | The Massachusetts General Hospital | Process for producing antibodies to hepatitis virus and cell lines therefor |
US4349539A (en) * | 1980-08-15 | 1982-09-14 | Merck & Co., Inc. | Separation of hepatitis B surface antigen |
EP0062574A3 (de) * | 1981-03-31 | 1982-12-29 | The Regents Of The University Of California | Synthese von Virusproteinen |
GR76274B (de) * | 1981-08-04 | 1984-08-04 | Univ California | |
NZ201705A (en) * | 1981-08-31 | 1986-03-14 | Genentech Inc | Recombinant dna method for production of hepatitis b surface antigen in yeast |
US4442205A (en) * | 1981-09-22 | 1984-04-10 | The United States Of America As Represented By The Department Of Health And Human Services | Simian virus recombinant that directs the synthesis of hepatitis B surface antigen |
JPS5936698A (ja) * | 1982-08-20 | 1984-02-28 | Science & Tech Agency | B型肝炎ウイルス遺伝子を組込んだ組換えdnaおよび形質転換動物細胞 |
-
1984
- 1984-07-09 US US06/629,295 patent/US4624918A/en not_active Expired - Lifetime
-
1985
- 1985-07-08 EP EP85304849A patent/EP0168234B1/de not_active Expired - Lifetime
- 1985-07-08 DE DE85304849T patent/DE3587298T2/de not_active Expired - Lifetime
- 1985-07-08 AT AT85304849T patent/ATE88718T1/de not_active IP Right Cessation
- 1985-07-09 JP JP60152140A patent/JPH0675B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0168234B1 (de) | 1993-04-28 |
JPS6136228A (ja) | 1986-02-20 |
DE3587298D1 (de) | 1993-06-03 |
EP0168234A3 (en) | 1988-09-14 |
DE3587298T2 (de) | 1993-10-21 |
JPH0675B2 (ja) | 1994-01-05 |
US4624918A (en) | 1986-11-25 |
EP0168234A2 (de) | 1986-01-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
EELA | Cancelled due to lapse of time |