ATE82137T1 - IMPROVING SKIN PENETRATION BY USING MIXTURES OF FREE BASE WITH ACIDIC SALT ADDITION OF ACTIVE INGREDIENTS. - Google Patents

IMPROVING SKIN PENETRATION BY USING MIXTURES OF FREE BASE WITH ACIDIC SALT ADDITION OF ACTIVE INGREDIENTS.

Info

Publication number
ATE82137T1
ATE82137T1 AT88121046T AT88121046T ATE82137T1 AT E82137 T1 ATE82137 T1 AT E82137T1 AT 88121046 T AT88121046 T AT 88121046T AT 88121046 T AT88121046 T AT 88121046T AT E82137 T1 ATE82137 T1 AT E82137T1
Authority
AT
Austria
Prior art keywords
free base
skin penetration
acid addition
addition salt
mixtures
Prior art date
Application number
AT88121046T
Other languages
German (de)
Inventor
Dinesh C Patel
Yunik Chang
Original Assignee
Theratech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theratech Inc filed Critical Theratech Inc
Application granted granted Critical
Publication of ATE82137T1 publication Critical patent/ATE82137T1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)

Abstract

The invention is directed to compositions for topical application made up of active pharmaceutical permeants capable of existing in both free base and acid addition salt form. The permeants are present as a combination of both free base and acid addition salt forms. These combined forms provide skin penetration rates which are greater than the penetration rate of either the free base or acid addition salt forms utilized separately. The combined free base-acid addition salt permeants are formulated in a carrier vehicle which preferably also possesses skin penetration enhancement activity.
AT88121046T 1987-12-21 1988-12-15 IMPROVING SKIN PENETRATION BY USING MIXTURES OF FREE BASE WITH ACIDIC SALT ADDITION OF ACTIVE INGREDIENTS. ATE82137T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/136,115 US4888354A (en) 1987-12-21 1987-12-21 Skin penetration enhancement using free base and acid addition salt combinations of active agents
EP88121046A EP0321870B1 (en) 1987-12-21 1988-12-15 Skin penetration enhancement using free base and acid addition salt combinations of active agents

Publications (1)

Publication Number Publication Date
ATE82137T1 true ATE82137T1 (en) 1992-11-15

Family

ID=22471370

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88121046T ATE82137T1 (en) 1987-12-21 1988-12-15 IMPROVING SKIN PENETRATION BY USING MIXTURES OF FREE BASE WITH ACIDIC SALT ADDITION OF ACTIVE INGREDIENTS.

Country Status (9)

Country Link
US (1) US4888354A (en)
EP (1) EP0321870B1 (en)
JP (1) JP2856407B2 (en)
KR (1) KR970007898B1 (en)
AT (1) ATE82137T1 (en)
CA (1) CA1332713C (en)
DE (1) DE3875931T2 (en)
ES (1) ES2052682T3 (en)
GR (1) GR3006499T3 (en)

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Also Published As

Publication number Publication date
DE3875931T2 (en) 1993-03-25
JPH02104516A (en) 1990-04-17
ES2052682T3 (en) 1994-07-16
JP2856407B2 (en) 1999-02-10
GR3006499T3 (en) 1993-06-21
DE3875931D1 (en) 1992-12-17
EP0321870A1 (en) 1989-06-28
KR970007898B1 (en) 1997-05-17
US4888354A (en) 1989-12-19
CA1332713C (en) 1994-10-25
KR890009374A (en) 1989-08-01
EP0321870B1 (en) 1992-11-11

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