ATE798T1 - ANTI-INFLAMMATORY 1-PHE NYL-2-AMINOAETHANOL DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FOR TOPICAL USE. - Google Patents

ANTI-INFLAMMATORY 1-PHE NYL-2-AMINOAETHANOL DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FOR TOPICAL USE.

Info

Publication number
ATE798T1
ATE798T1 AT79300893T AT79300893T ATE798T1 AT E798 T1 ATE798 T1 AT E798T1 AT 79300893 T AT79300893 T AT 79300893T AT 79300893 T AT79300893 T AT 79300893T AT E798 T1 ATE798 T1 AT E798T1
Authority
AT
Austria
Prior art keywords
sup
sub
derivatives
inflammatory
phenyl
Prior art date
Application number
AT79300893T
Other languages
German (de)
Inventor
Geraint Jones
Original Assignee
Imperial Chemical Industries Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Plc filed Critical Imperial Chemical Industries Plc
Application granted granted Critical
Publication of ATE798T1 publication Critical patent/ATE798T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

The invention concerns new topical anti-inflammatory 1-phenyl-2-aminoethanol derivatives of the general formula: R<sup>1</sup>·CH(OH)·CH<sub>2</sub>NH· CR<sup>2</sup>R<sup>3</sup>· A NH[CO·Y· NH]<sub>n</sub>·Q wherein R' is a radical of formulain which W<sup>1</sup> is a (2-12C)alkanoyloxyradical, one of W<sup>2</sup> and W<sup>3</sup> is hydrogen and the other of W<sup>2</sup> and W<sup>3</sup> is a (2-12C)-alkanoyloxyradical and A<sup>2</sup> is a direct bond or a methylene diradical, or R<sup>1</sup> is a phenyl, 2-chlorophenyl or 3,5-dichloro-4-aminoradical, R<sup>2</sup> and R<sup>3</sup> are independently hydrogen or (1-4C)alkyl, A' is a (1-4C)alkylene, Y is a (1-4C)alkylene optionally bearing a (1-4C)alkyl or benzyl, n is an integer from 1 to 4, and Q is an optionally substituted benzoyl, phenylacetyl, or phenoxyacetyl provided that when n is other than 1, Y in the individual diradicals of the formula [CO·Y·NH] may have the same or different values, or together with the acid-addition salts thereof; and the pharmaceutical compositions thereof, for use in the treatment of inflammatory skin diseases and conditions. The invention also concerns processes for the manufacture of derivatives of formula I.A representative compound of the invention is 1-[3,4- bis(pivaloyloxy) phenyl]-2-{2-[(N-benzoylglycyl)amino]-1,1-dimethyl-ethylamino}ethanol.
AT79300893T 1978-06-15 1979-05-21 ANTI-INFLAMMATORY 1-PHE NYL-2-AMINOAETHANOL DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FOR TOPICAL USE. ATE798T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7827026 1978-06-15
EP79300893A EP0006298B1 (en) 1978-06-15 1979-05-21 Anti-inflammatory 1-phenyl-2-aminoethanol derivatives, pharmaceutical compositions thereof for topical use, and processes for their manufacture

Publications (1)

Publication Number Publication Date
ATE798T1 true ATE798T1 (en) 1982-04-15

Family

ID=10497984

Family Applications (1)

Application Number Title Priority Date Filing Date
AT79300893T ATE798T1 (en) 1978-06-15 1979-05-21 ANTI-INFLAMMATORY 1-PHE NYL-2-AMINOAETHANOL DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FOR TOPICAL USE.

Country Status (13)

Country Link
US (1) US4303649A (en)
EP (1) EP0006298B1 (en)
JP (1) JPS554377A (en)
AT (1) ATE798T1 (en)
AU (1) AU525094B2 (en)
CA (1) CA1137978A (en)
DE (1) DE2962383D1 (en)
DK (1) DK247479A (en)
FI (1) FI791908A (en)
IE (1) IE48337B1 (en)
IL (1) IL57497A (en)
NZ (1) NZ190581A (en)
ZA (1) ZA792622B (en)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE54220B1 (en) * 1981-12-23 1989-07-19 Ici Plc Phenol esters
US5331012A (en) * 1990-07-30 1994-07-19 Riddick Kenneth B Topical pharmaceutical preparation for fever blisters and other viral infections and method of use
GB9212673D0 (en) * 1992-06-15 1992-07-29 Celltech Ltd Chemical compounds
GB9222253D0 (en) * 1992-10-23 1992-12-09 Celltech Ltd Chemical compounds
DE69329544T2 (en) * 1992-12-22 2001-05-31 Lilly Co Eli HIV protease inhibiting compounds
US5622977A (en) * 1992-12-23 1997-04-22 Celltech Therapeutics Limited Tri-substituted (aryl or heteroaryl) derivatives and pharmaceutical compositions containing the same
GB9226830D0 (en) * 1992-12-23 1993-02-17 Celltech Ltd Chemical compounds
GB9304920D0 (en) * 1993-03-10 1993-04-28 Celltech Ltd Chemical compounds
GB9304919D0 (en) * 1993-03-10 1993-04-28 Celltech Ltd Chemical compounds
GB9326173D0 (en) * 1993-12-22 1994-02-23 Celltech Ltd Chemical compounds and process
DE69433594T2 (en) * 1993-12-22 2004-08-05 Celltech R&D Ltd., Slough TRISUBSTITUTED PHENYL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THE USE THEREOF AS PHOSPHODIESTERASE (TYPE IV) INHIBITORS
US5786354A (en) * 1994-06-21 1998-07-28 Celltech Therapeutics, Limited Tri-substituted phenyl derivatives and processes for their preparation
US6245774B1 (en) 1994-06-21 2001-06-12 Celltech Therapeutics Limited Tri-substituted phenyl or pyridine derivatives
GB9412573D0 (en) * 1994-06-22 1994-08-10 Celltech Ltd Chemical compounds
GB9412571D0 (en) 1994-06-22 1994-08-10 Celltech Ltd Chemical compounds
GB9412672D0 (en) * 1994-06-23 1994-08-10 Celltech Ltd Chemical compounds
GB9523675D0 (en) 1995-11-20 1996-01-24 Celltech Therapeutics Ltd Chemical compounds
GB9526245D0 (en) * 1995-12-21 1996-02-21 Celltech Therapeutics Ltd Chemical compounds
GB9526243D0 (en) * 1995-12-21 1996-02-21 Celltech Therapeutics Ltd Chemical compounds
GB9526246D0 (en) * 1995-12-21 1996-02-21 Celltech Therapeutics Ltd Chemical compounds
GB9608435D0 (en) * 1996-04-24 1996-06-26 Celltech Therapeutics Ltd Chemical compounds
GB9619284D0 (en) * 1996-09-16 1996-10-30 Celltech Therapeutics Ltd Chemical compounds
GB9622363D0 (en) 1996-10-28 1997-01-08 Celltech Therapeutics Ltd Chemical compounds
GB9625184D0 (en) * 1996-12-04 1997-01-22 Celltech Therapeutics Ltd Chemical compounds
EP0946523A1 (en) * 1996-12-23 1999-10-06 Celltech Therapeutics Limited Fused polycyclic 2-aminopyrimidine derivatives, their preparation and their use as protein tyrosine kinase inhibitors
GB9705361D0 (en) 1997-03-14 1997-04-30 Celltech Therapeutics Ltd Chemical compounds
GB9713087D0 (en) * 1997-06-20 1997-08-27 Celltech Therapeutics Ltd Chemical compounds
NO311317B1 (en) 1999-04-30 2001-11-12 Thin Film Electronics Asa Apparatus comprising electronic and / or optoelectronic circuits and method of realizing and / or integrating circuits of this kind in the apparatus
GB9914258D0 (en) * 1999-06-18 1999-08-18 Celltech Therapeutics Ltd Chemical compounds
GB9924862D0 (en) * 1999-10-20 1999-12-22 Celltech Therapeutics Ltd Chemical compounds
MXPA03010810A (en) 2001-05-29 2004-03-22 Schering Ag Cdk inhibiting pyrimidines, production thereof and their use as medicaments.
DK3095512T3 (en) * 2009-02-11 2018-12-10 Xyleco Inc CREATION OF BIOMASS BY IONIZING RADIATION
CU24372B1 (en) 2012-10-10 2018-11-06 Xyleco Inc BIOMASS PROCESSING
UA117352C2 (en) 2012-10-10 2018-07-25 Ксілеко, Інк. Treating biomass
NZ743055A (en) 2013-03-08 2020-03-27 Xyleco Inc Equipment protecting enclosures
CN103588662B (en) * 2013-11-06 2015-07-01 浙江大学 Method for synthesis of betamipron in continuous-flow microreactor

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1460593A (en) * 1973-06-22 1977-01-06 Ici Ltd Ethanolamine derivatives
US4034112A (en) * 1973-06-22 1977-07-05 Imperial Chemical Industries Limited Ethanolamine derivatives having β-adrenergic blocking activity
GB1468156A (en) * 1973-07-19 1977-03-23 Ici Ltd Phenylethylamine derivatives
US4041074A (en) * 1973-07-19 1977-08-09 Imperial Chemical Industries Limited 1-Hydroxyaryl-2-amidoalkylaminoethanol derivatives
US4041075A (en) * 1973-12-12 1977-08-09 Imperial Chemical Industries Limited Phenoxy-alkanolamine derivatives
US3928621A (en) * 1974-10-10 1975-12-23 Hoffmann La Roche Antiinflammatory 2-(2-aminoalkylamino)-1,2-diphenylethanols
US4038417A (en) * 1975-06-19 1977-07-26 Nelson Research & Development Company Method for treatment of psoriasis
GB1509300A (en) * 1975-12-05 1978-05-04 Ici Ltd Ethanolamine derivatives
US4154761A (en) * 1976-02-09 1979-05-15 Allen & Hanburys Limited Pharmacologically active compounds
GB1540463A (en) * 1976-10-07 1979-02-14 Ici Ltd Alkanolamine derivatives
IE45991B1 (en) * 1976-12-16 1983-01-26 Ici Ltd Esters of hydroxy amino amides

Also Published As

Publication number Publication date
NZ190581A (en) 1981-12-15
CA1137978A (en) 1982-12-21
US4303649A (en) 1981-12-01
IE48337B1 (en) 1984-12-12
ZA792622B (en) 1980-02-27
DE2962383D1 (en) 1982-05-06
IE791004L (en) 1979-12-15
JPS554377A (en) 1980-01-12
DK247479A (en) 1979-12-16
AU525094B2 (en) 1982-10-21
AU4765279A (en) 1979-12-20
EP0006298A1 (en) 1980-01-09
IL57497A (en) 1982-09-30
EP0006298B1 (en) 1982-03-31
IL57497A0 (en) 1979-10-31
FI791908A (en) 1979-12-16

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee