ATE556315T1 - Mikrohergestellte strukturen um die einführung von fluiden in mikrofluidischen systemen zu erleichtern - Google Patents

Mikrohergestellte strukturen um die einführung von fluiden in mikrofluidischen systemen zu erleichtern

Info

Publication number
ATE556315T1
ATE556315T1 AT98926348T AT98926348T ATE556315T1 AT E556315 T1 ATE556315 T1 AT E556315T1 AT 98926348 T AT98926348 T AT 98926348T AT 98926348 T AT98926348 T AT 98926348T AT E556315 T1 ATE556315 T1 AT E556315T1
Authority
AT
Austria
Prior art keywords
fluid
port
introduction
channel
fluids
Prior art date
Application number
AT98926348T
Other languages
English (en)
Inventor
Steven Sundberg
J Parce
Calvin Chow
Original Assignee
Caliper Life Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25356382&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE556315(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Caliper Life Sciences Inc filed Critical Caliper Life Sciences Inc
Application granted granted Critical
Publication of ATE556315T1 publication Critical patent/ATE556315T1/de

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416Systems
    • G01N27/447Systems using electrophoresis
    • G01N27/44756Apparatus specially adapted therefor
    • G01N27/44791Microapparatus
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093Microreactors, e.g. miniaturised or microfabricated reactors
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02Burettes; Pipettes
    • B01L3/0241Drop counters; Drop formers
    • B01L3/0244Drop counters; Drop formers using pins
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02Burettes; Pipettes
    • B01L3/0241Drop counters; Drop formers
    • B01L3/0262Drop counters; Drop formers using touch-off at substrate or container
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B01L3/50255Multi-well filtration
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416Systems
    • G01N27/447Systems using electrophoresis
    • G01N27/44704Details; Accessories
    • G01N27/44743Introducing samples
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00783Laminate assemblies, i.e. the reactor comprising a stack of plates
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00819Materials of construction
    • B01J2219/00824Ceramic
    • B01J2219/00826Quartz
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00819Materials of construction
    • B01J2219/00831Glass
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00819Materials of construction
    • B01J2219/00833Plastic
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00851Additional features
    • B01J2219/00853Employing electrode arrangements
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00891Feeding or evacuation
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00905Separation
    • B01J2219/00909Separation using filters
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02Adapting objects or devices to another
    • B01L2200/026Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/06Auxiliary integrated devices, integrated components
    • B01L2300/0681Filter
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0816Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0819Microarrays; Biochips
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406Moving fluids with specific forces or mechanical means specific forces capillary forces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0418Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electro-osmotic flow [EOF]
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0421Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0475Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/06Valves, specific forms thereof
    • B01L2400/0688Valves, specific forms thereof surface tension valves, capillary stop, capillary break
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502723Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by venting arrangements
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178Special arrangements of analysers
    • G01N2035/00237Handling microquantities of analyte, e.g. microvalves, capillary networks
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027General features of the devices
    • G01N2035/1034Transferring microquantities of liquid
    • G01N2035/1037Using surface tension, e.g. pins or wires
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25125Digestion or removing interfering materials
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575Volumetric liquid transfer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Electrochemistry (AREA)
  • Organic Chemistry (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Micromachines (AREA)
AT98926348T 1997-06-06 1998-06-04 Mikrohergestellte strukturen um die einführung von fluiden in mikrofluidischen systemen zu erleichtern ATE556315T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/870,944 US6090251A (en) 1997-06-06 1997-06-06 Microfabricated structures for facilitating fluid introduction into microfluidic devices
PCT/US1998/011667 WO1998055852A1 (en) 1997-06-06 1998-06-04 Microfabricated structures for facilitating fluid introduction into microfluidic devices

Publications (1)

Publication Number Publication Date
ATE556315T1 true ATE556315T1 (de) 2012-05-15

Family

ID=25356382

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98926348T ATE556315T1 (de) 1997-06-06 1998-06-04 Mikrohergestellte strukturen um die einführung von fluiden in mikrofluidischen systemen zu erleichtern

Country Status (6)

Country Link
US (13) US6090251A (de)
EP (1) EP0988530B1 (de)
AT (1) ATE556315T1 (de)
AU (1) AU734146B2 (de)
CA (1) CA2290633A1 (de)
WO (1) WO1998055852A1 (de)

Families Citing this family (355)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6794127B1 (en) * 1997-06-16 2004-09-21 Diversa Corporation Capillary array-based sample screening
US6972183B1 (en) 1997-06-16 2005-12-06 Diversa Corporation Capillary array-based enzyme screening
US20020048809A1 (en) * 1997-06-16 2002-04-25 Lafferty William Micharl Capillary array-based sample screening
US20010041333A1 (en) * 1997-06-16 2001-11-15 Short Jay M. High throughput screening for a bioactivity or biomolecule
US5885470A (en) 1997-04-14 1999-03-23 Caliper Technologies Corporation Controlled fluid transport in microfabricated polymeric substrates
EP0907412B1 (de) 1996-06-28 2008-08-27 Caliper Life Sciences, Inc. Hochdurchsatz-screening-testsystem mittels mikrofluidischer vorrichtungen
US7033474B1 (en) 1997-04-25 2006-04-25 Caliper Life Sciences, Inc. Microfluidic devices incorporating improved channel geometries
WO1998049548A1 (en) * 1997-04-25 1998-11-05 Caliper Technologies Corporation Microfluidic devices incorporating improved channel geometries
US6090251A (en) * 1997-06-06 2000-07-18 Caliper Technologies, Inc. Microfabricated structures for facilitating fluid introduction into microfluidic devices
WO1998056956A1 (en) 1997-06-09 1998-12-17 Caliper Technologies Corporation Apparatus and methods for correcting for variable velocity in microfluidic systems
US20050070005A1 (en) * 1997-06-16 2005-03-31 Martin Keller High throughput or capillary-based screening for a bioactivity or biomolecule
US20030013115A1 (en) * 1997-06-16 2003-01-16 Diversa Corporation, A Delaware Corporation Capillary array-based sample screening
US20020015997A1 (en) * 1997-06-16 2002-02-07 Lafferty William Michael Capillary array-based sample screening
US20040241759A1 (en) * 1997-06-16 2004-12-02 Eileen Tozer High throughput screening of libraries
US20030077620A1 (en) * 1997-06-16 2003-04-24 Diversa Corporation, A Delaware Corporation High throughput screening for sequences of interest
US5989402A (en) 1997-08-29 1999-11-23 Caliper Technologies Corp. Controller/detector interfaces for microfluidic systems
US6207031B1 (en) * 1997-09-15 2001-03-27 Whitehead Institute For Biomedical Research Methods and apparatus for processing a sample of biomolecular analyte using a microfabricated device
ATE477850T1 (de) * 1998-01-12 2010-09-15 Massachusetts Inst Technology Vorrichtung zur mikrotestdurchführung
US6893877B2 (en) 1998-01-12 2005-05-17 Massachusetts Institute Of Technology Methods for screening substances in a microwell array
US20040126895A1 (en) * 1998-01-13 2004-07-01 James W. Overbeck Depositing fluid specimens on substrates, resulting ordered arrays, techniques for analysis of deposited arrays
US6722395B2 (en) 1998-01-13 2004-04-20 James W. Overbeck Depositing fluid specimens on substrates, resulting ordered arrays, techniques for analysis of deposited arrays
US6428752B1 (en) 1998-05-14 2002-08-06 Affymetrix, Inc. Cleaning deposit devices that form microarrays and the like
US6251343B1 (en) 1998-02-24 2001-06-26 Caliper Technologies Corp. Microfluidic devices and systems incorporating cover layers
US6756019B1 (en) 1998-02-24 2004-06-29 Caliper Technologies Corp. Microfluidic devices and systems incorporating cover layers
US7497994B2 (en) 1998-02-24 2009-03-03 Khushroo Gandhi Microfluidic devices and systems incorporating cover layers
US6884626B1 (en) 1998-04-27 2005-04-26 Corning Incorporated Redrawn capillary imaging reservoir
EP0955084B1 (de) 1998-04-27 2006-07-26 Corning Incorporated Verfahren zur Ablage von biologischen Proben mit hilfe eines nachgezogenen Kapillar-speichers
US6306590B1 (en) 1998-06-08 2001-10-23 Caliper Technologies Corp. Microfluidic matrix localization apparatus and methods
AU747464B2 (en) 1998-06-08 2002-05-16 Caliper Technologies Corporation Microfluidic devices, systems and methods for performing integrated reactions and separations
DE19826020C2 (de) * 1998-06-10 2000-11-02 Max Planck Gesellschaft Vorrichtung und Verfahren zur miniaturisierten, hochparallelen elektrophoretischen Trennung
US6762061B1 (en) * 1998-07-03 2004-07-13 Corning Incorporated Redrawn capillary imaging reservoir
US6540896B1 (en) * 1998-08-05 2003-04-01 Caliper Technologies Corp. Open-Field serial to parallel converter
US6716394B2 (en) 1998-08-11 2004-04-06 Caliper Technologies Corp. DNA sequencing using multiple fluorescent labels being distinguishable by their decay times
US6447724B1 (en) 1998-08-11 2002-09-10 Caliper Technologies Corp. DNA sequencing using multiple fluorescent labels being distinguishable by their decay times
US6759013B2 (en) * 1998-09-17 2004-07-06 Agilent Technologies, Inc. Modular apparatus for chemical microanalysis
US6637463B1 (en) 1998-10-13 2003-10-28 Biomicro Systems, Inc. Multi-channel microfluidic system design with balanced fluid flow distribution
KR20010089295A (ko) 1998-10-13 2001-09-29 마이클 알. 맥닐리 수동 유체 동역학에 의한 유체회로 및 유체회로내에서의방법
US6591852B1 (en) 1998-10-13 2003-07-15 Biomicro Systems, Inc. Fluid circuit components based upon passive fluid dynamics
US6601613B2 (en) 1998-10-13 2003-08-05 Biomicro Systems, Inc. Fluid circuit components based upon passive fluid dynamics
US6149787A (en) 1998-10-14 2000-11-21 Caliper Technologies Corp. External material accession systems and methods
US6110332A (en) * 1998-10-26 2000-08-29 The Regents Of The University Of California T-load microchannel array and fabrication method
US6689323B2 (en) * 1998-10-30 2004-02-10 Agilent Technologies Method and apparatus for liquid transfer
SE9803734D0 (sv) * 1998-10-30 1998-10-30 Amersham Pharm Biotech Ab Liquid handling system
US6416642B1 (en) 1999-01-21 2002-07-09 Caliper Technologies Corp. Method and apparatus for continuous liquid flow in microscale channels using pressure injection, wicking, and electrokinetic injection
JP2003517581A (ja) * 1999-02-16 2003-05-27 ピーイー コーポレイション (エヌワイ) ビーズ分散システム
US6632655B1 (en) 1999-02-23 2003-10-14 Caliper Technologies Corp. Manipulation of microparticles in microfluidic systems
US7150994B2 (en) 1999-03-03 2006-12-19 Symyx Technologies, Inc. Parallel flow process optimization reactor
US6326083B1 (en) 1999-03-08 2001-12-04 Calipher Technologies Corp. Surface coating for microfluidic devices that incorporate a biopolymer resistant moiety
FR2790684B1 (fr) * 1999-03-09 2001-05-11 Biomerieux Sa Appareil permettant en son sein le transfert de liquides par capillarite
US6296702B1 (en) * 1999-03-15 2001-10-02 Pe Corporation (Ny) Apparatus and method for spotting a substrate
BR0009164A (pt) 1999-03-19 2001-12-26 Genencor Int Placa de teste de múltiplos furos vazados paraseparação de alto desempenho
AU3963300A (en) * 1999-03-30 2000-10-16 Institut Fur Mikrotechnik Mainz Gmbh Electrophoresis chip and device for operating an electrophoresis chip
US6303343B1 (en) 1999-04-06 2001-10-16 Caliper Technologies Corp. Inefficient fast PCR
US6458259B1 (en) 1999-05-11 2002-10-01 Caliper Technologies Corp. Prevention of surface adsorption in microchannels by application of electric current during pressure-induced flow
US6592821B1 (en) 1999-05-17 2003-07-15 Caliper Technologies Corp. Focusing of microparticles in microfluidic systems
CA2373347A1 (en) 1999-05-17 2000-11-23 Caliper Technologies Corporation Focusing of microparticles in microfluidic systems
WO2000073799A1 (en) 1999-06-01 2000-12-07 Caliper Technologies Corp. Microscale assays and microfluidic devices for transporter, gradient induced, and binding activities
US20050161334A1 (en) * 1999-06-01 2005-07-28 Paul Phillip H. Electroosmotic flow systems
US6613580B1 (en) 1999-07-06 2003-09-02 Caliper Technologies Corp. Microfluidic systems and methods for determining modulator kinetics
WO2001009598A1 (en) * 1999-07-28 2001-02-08 University Of Washington Fluidic interconnect, interconnect manifold and microfluidic devices for internal delivery of gases and application of vacuum
US6696022B1 (en) * 1999-08-13 2004-02-24 U.S. Genomics, Inc. Methods and apparatuses for stretching polymers
DE29914360U1 (de) * 1999-08-17 2001-01-11 Mwg Biotech Ag Probengeber
US6858185B1 (en) 1999-08-25 2005-02-22 Caliper Life Sciences, Inc. Dilutions in high throughput systems with a single vacuum source
US6613581B1 (en) 1999-08-26 2003-09-02 Caliper Technologies Corp. Microfluidic analytic detection assays, devices, and integrated systems
US6383748B1 (en) 1999-09-14 2002-05-07 Pamgene B.V. Analytical test device with substrate having oriented through going channels and improved methods and apparatus for using same
WO2001019502A2 (en) * 1999-09-17 2001-03-22 Millipore Corporation High throughput screening card
AU7747600A (en) * 1999-10-01 2002-05-15 University Of California, The Microfabricated liquid sample loading system
WO2001027253A1 (en) 1999-10-08 2001-04-19 Caliper Technologies Corp. Use of nernstein voltage sensitive dyes in measuring transmembrane voltage
WO2001026813A2 (en) 1999-10-08 2001-04-19 Micronics, Inc. Microfluidics without electrically of mechanically operated pumps
US6468761B2 (en) 2000-01-07 2002-10-22 Caliper Technologies, Corp. Microfluidic in-line labeling method for continuous-flow protease inhibition analysis
US7037416B2 (en) 2000-01-14 2006-05-02 Caliper Life Sciences, Inc. Method for monitoring flow rate using fluorescent markers
US6939452B2 (en) * 2000-01-18 2005-09-06 Northeastern University Parallel sample loading and injection device for multichannel microfluidic devices
WO2001053794A1 (en) * 2000-01-18 2001-07-26 Northeastern University Parallel sample loading and injection device for multichannel microfluidic devices
US6399396B1 (en) * 2000-01-28 2002-06-04 Agilent Technologies, Inc. Compressed loading apparatus and method for liquid transfer
US20020151040A1 (en) 2000-02-18 2002-10-17 Matthew O' Keefe Apparatus and methods for parallel processing of microvolume liquid reactions
WO2001066245A2 (en) 2000-03-07 2001-09-13 Symyx Technologies, Inc. Parallel flow process optimization reactor
US7485454B1 (en) 2000-03-10 2009-02-03 Bioprocessors Corp. Microreactor
US20020012971A1 (en) 2000-03-20 2002-01-31 Mehta Tammy Burd PCR compatible nucleic acid sieving medium
US6571651B1 (en) * 2000-03-27 2003-06-03 Lifescan, Inc. Method of preventing short sampling of a capillary or wicking fill device
AU4270401A (en) * 2000-04-03 2001-10-15 Ecole Polytechnique Federale De Lausanne A device for dispensing accurately-controlled small doses of liquid
US6561208B1 (en) 2000-04-14 2003-05-13 Nanostream, Inc. Fluidic impedances in microfluidic system
US6733645B1 (en) 2000-04-18 2004-05-11 Caliper Technologies Corp. Total analyte quantitation
AU2001259355B2 (en) 2000-05-03 2005-09-01 Caliper Life Sciences, Inc. Multi depth substrate fabrication processes
US6893562B2 (en) 2000-05-05 2005-05-17 Millipore Corporation Underdrain for filtration membrane
CA2406718A1 (en) 2000-05-11 2001-11-15 Caliper Technologies Corp. Microfluidic devices and methods to regulate hydrodynamic and electrical resistance utilizing bulk viscosity enhancers
CA2407141A1 (en) 2000-05-12 2001-11-22 Caliper Technologies Corporation Detection of nucleic acid hybridization by fluorescence polarization
JP2004502926A (ja) * 2000-05-24 2004-01-29 マイクロニックス、インコーポレーテッド 濃度勾配をもたらすマイクロ流体用装置
JP2004503361A (ja) * 2000-06-14 2004-02-05 ボード・オブ・リージェンツ,ザ・ユニヴァーシティ・オヴ・テキサス・システム 流体注入のための装置および方法
US20020159918A1 (en) * 2000-06-25 2002-10-31 Fan-Gang Tseng Micro-fabricated stamp array for depositing biologic diagnostic testing samples on bio-bindable surface
US20040018615A1 (en) * 2000-08-02 2004-01-29 Garyantes Tina K. Virtual wells for use in high throughput screening assays
US7192559B2 (en) 2000-08-03 2007-03-20 Caliper Life Sciences, Inc. Methods and devices for high throughput fluid delivery
US6902702B1 (en) * 2000-08-16 2005-06-07 University Health Network Devices and methods for producing microarrays of biological samples
US20050106621A1 (en) * 2000-08-16 2005-05-19 Winegarden Neil A. Devices and methods for producing microarrays of biological samples
US6789040B2 (en) 2000-08-22 2004-09-07 Affymetrix, Inc. System, method, and computer software product for specifying a scanning area of a substrate
US6692972B1 (en) * 2000-08-24 2004-02-17 University Of Chicago Device for producing microscopic arrays of molecules, a method for producing microscopic arrays of molecules
US6994826B1 (en) * 2000-09-26 2006-02-07 Sandia National Laboratories Method and apparatus for controlling cross contamination of microfluid channels
US20090118139A1 (en) 2000-11-07 2009-05-07 Caliper Life Sciences, Inc. Microfluidic method and system for enzyme inhibition activity screening
WO2002060582A2 (en) * 2000-11-16 2002-08-08 Fluidigm Corporation Microfluidic devices for introducing and dispensing fluids from microfluidic systems
SE0004352D0 (sv) * 2000-11-27 2000-11-27 Helen Andersson System och metod för anslutning av vätskor i ett mikrofluidiskt flödescellsystem
US6387791B1 (en) * 2000-12-14 2002-05-14 Bae Systems, Information And Electronic Systems Integration, Inc. Method for manufacturing microscopic canals within a semiconductor
US20020108860A1 (en) * 2001-01-15 2002-08-15 Staats Sau Lan Tang Fabrication of polymeric microfluidic devices
US20020100714A1 (en) * 2001-01-31 2002-08-01 Sau Lan Tang Staats Microfluidic devices
WO2002064253A2 (en) * 2001-02-09 2002-08-22 Microchem Solutions Method and apparatus for sample injection in microfabricated devices
WO2002070118A2 (en) * 2001-02-09 2002-09-12 Microchem Solutions Apparatus and method for small-volume fluid manipulation and transportation
US7118917B2 (en) 2001-03-07 2006-10-10 Symyx Technologies, Inc. Parallel flow reactor having improved thermal control
US6886409B2 (en) 2001-03-13 2005-05-03 Pamgene International B.V. System for controlling the flow of a fluid through a substrate
US7105134B2 (en) 2001-03-13 2006-09-12 Pamgene B.V. Device for holding a substrate
US20030040119A1 (en) * 2001-04-11 2003-02-27 The Regents Of The University Of Michigan Separation devices and methods for separating particles
US6811752B2 (en) * 2001-05-15 2004-11-02 Biocrystal, Ltd. Device having microchambers and microfluidics
US7723123B1 (en) 2001-06-05 2010-05-25 Caliper Life Sciences, Inc. Western blot by incorporating an affinity purification zone
DE60118533T2 (de) * 2001-06-07 2006-08-24 Agilent Technologies, Inc. (n.d.Ges.d.Staates Delaware), Palo Alto Analytischer Mikrochip mit Eingabe- und Ausgabeleitungen zwischen Wanne und Behälter
WO2002103210A1 (en) * 2001-06-15 2002-12-27 Hansford Derek J Nanopump devices and methods
US20030077570A1 (en) * 2001-09-20 2003-04-24 Coventor, Inc. Small molecule substrate based enzyme activity assays
US7041257B2 (en) * 2001-09-25 2006-05-09 Cytonome, Inc. Microfabricated two-pin liquid sample dispensing system
US20030015425A1 (en) * 2001-06-20 2003-01-23 Coventor Inc. Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system
US20020195343A1 (en) * 2001-06-20 2002-12-26 Coventor, Inc. Microfabricated separation device employing a virtual wall for interfacing fluids
US7419574B2 (en) * 2001-06-20 2008-09-02 Cummings Eric B Dielectrophoresis device and method having non-uniform arrays for manipulating particles
US7179423B2 (en) * 2001-06-20 2007-02-20 Cytonome, Inc. Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system
JP2005514187A (ja) * 2001-06-20 2005-05-19 サイトノーム インコーポレーテッド 流体をマイクロ流体システムと相互接続するための仮想壁流体相互接続ポートを含むマイクロ流体システム
US20020197733A1 (en) * 2001-06-20 2002-12-26 Coventor, Inc. Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system
CA2451201A1 (en) * 2001-06-20 2003-01-03 Cytonome, Inc. Microfabricated two-pin liquid sample dispensing system
WO2003001192A1 (en) * 2001-06-20 2003-01-03 Cytonome, Inc. Microfabricated separation device employing a virtual wall for interfacing fluids
US7211442B2 (en) * 2001-06-20 2007-05-01 Cytonome, Inc. Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system
US6835293B2 (en) * 2001-07-09 2004-12-28 Greiner Bio-One Gmbh Analysis system
US6825127B2 (en) 2001-07-24 2004-11-30 Zarlink Semiconductor Inc. Micro-fluidic devices
US7169577B2 (en) 2001-07-27 2007-01-30 Surface Logix, Inc. Cell isolation and screening device and method of using same
US7285412B2 (en) * 2001-07-27 2007-10-23 Surface Logix Inc. Device for magnetic immobilization of cells
US7169578B2 (en) 2001-07-27 2007-01-30 Surface Logix, Inc. Cell isolation and screening device and method of using same
US20030032198A1 (en) * 2001-08-13 2003-02-13 Symyx Technologies, Inc. High throughput dispensing of fluids
US20080288178A1 (en) * 2001-08-24 2008-11-20 Applera Corporation Sequencing system with memory
US6969489B2 (en) 2001-08-24 2005-11-29 Cytoplex Biosciences Micro array for high throughout screening
US6726820B1 (en) * 2001-09-19 2004-04-27 Applera Corporation Method of separating biomolecule-containing samples with a microdevice with integrated memory
US6995024B2 (en) * 2001-08-27 2006-02-07 Sri International Method and apparatus for electrostatic dispensing of microdroplets
CN1585627A (zh) 2001-09-14 2005-02-23 弗朗西斯J·马丁 用于持续释放治疗剂的显微制作的纳米微孔装置
US6803568B2 (en) * 2001-09-19 2004-10-12 Predicant Biosciences, Inc. Multi-channel microfluidic chip for electrospray ionization
US7153699B2 (en) * 2001-12-21 2006-12-26 Cytonome, Inc. Microfabricated two-pin system for biomolecule crystallization
US20070054408A1 (en) * 2001-09-25 2007-03-08 Cytonome, Inc. Microfabricated two-pin system for biomolecule crystallization
US6942018B2 (en) * 2001-09-28 2005-09-13 The Board Of Trustees Of The Leland Stanford Junior University Electroosmotic microchannel cooling system
US7758744B2 (en) * 2001-10-05 2010-07-20 Stephen Eliot Zweig Dual glucose-turbidimetric analytical sensors
US6984307B2 (en) * 2001-10-05 2006-01-10 Stephen Eliot Zweig Dual glucose-hydroxybutyrate analytical sensors
US6942836B2 (en) * 2001-10-16 2005-09-13 Applera Corporation System for filling substrate chambers with liquid
US8053249B2 (en) 2001-10-19 2011-11-08 Wisconsin Alumni Research Foundation Method of pumping fluid through a microfluidic device
US20030082632A1 (en) * 2001-10-25 2003-05-01 Cytoprint, Inc. Assay method and apparatus
JP2004042012A (ja) * 2001-10-26 2004-02-12 Nec Corp 分離装置、分析システム、分離方法および分離装置の製造方法
US6759012B2 (en) * 2001-11-05 2004-07-06 Genetix Limited Pin holder for a microarraying apparatus
US20030104512A1 (en) * 2001-11-30 2003-06-05 Freeman Alex R. Biosensors for single cell and multi cell analysis
US6800849B2 (en) 2001-12-19 2004-10-05 Sau Lan Tang Staats Microfluidic array devices and methods of manufacture and uses thereof
US6866762B2 (en) * 2001-12-20 2005-03-15 Board Of Regents, University Of Texas System Dielectric gate and methods for fluid injection and control
US7258839B2 (en) * 2001-12-21 2007-08-21 Cytonome, Inc. Temperature controlled microfabricated two-pin liquid sample dispensing system
US7105810B2 (en) * 2001-12-21 2006-09-12 Cornell Research Foundation, Inc. Electrospray emitter for microfluidic channel
EP1323474A1 (de) * 2001-12-31 2003-07-02 Corning Incorporated Vorrichtung und Verfahren zum simultanen Transfer von Flüssigkeiten
WO2003060505A1 (en) * 2002-01-04 2003-07-24 Board Of Regents, The University Of Texas System Wall-less channels for fluidic routing and confinement
US6827905B2 (en) * 2002-01-14 2004-12-07 Becton, Dickinson And Company Pin tool apparatus and method
US6606251B1 (en) 2002-02-07 2003-08-12 Cooligy Inc. Power conditioning module
WO2003072255A1 (en) * 2002-02-23 2003-09-04 Nanostream, Inc. Microfluidic multi-splitter
US7459127B2 (en) * 2002-02-26 2008-12-02 Siemens Healthcare Diagnostics Inc. Method and apparatus for precise transfer and manipulation of fluids by centrifugal and/or capillary forces
DE10210908A1 (de) * 2002-03-05 2003-12-04 Alfred Nordheim Vorrichtung zum Aufbringen von flüssigen Medien und Verfahren dazu
US7563621B2 (en) * 2002-03-05 2009-07-21 Siemens Healhcare Diagnostics Inc Absorbing organic reagents into diagnostic test devices by formation of amine salt complexes
EP2497564B1 (de) 2002-03-05 2014-05-14 Caliper Life Sciences, Inc. Elektrophoretische Trennung in einem mikrofluidischen Kanalnetzwerk
US7195986B1 (en) * 2002-03-08 2007-03-27 Caliper Life Sciences, Inc. Microfluidic device with controlled substrate conductivity
AU2003265228A1 (en) * 2002-03-12 2003-12-22 Surface Logix, Inc. Assay device that analyzes the absorption, metabolism, permeability and/or toxicity of a candidate compound
US7060170B2 (en) * 2002-05-01 2006-06-13 Eksigent Technologies Llc Bridges, elements and junctions for electroosmotic flow systems
US20030208936A1 (en) * 2002-05-09 2003-11-13 Lee Charles Hee Method for manufacturing embroidery decorated cards and envelopes
EP1364710B1 (de) * 2002-05-13 2009-10-07 Becton, Dickinson and Company Probenplatte mit Verteileraufsatz
SG111069A1 (en) * 2002-06-18 2005-05-30 Micron Technology Inc Semiconductor devices including peripherally located bond pads, assemblies, packages, and methods
US20050238506A1 (en) * 2002-06-21 2005-10-27 The Charles Stark Draper Laboratory, Inc. Electromagnetically-actuated microfluidic flow regulators and related applications
US7867193B2 (en) * 2004-01-29 2011-01-11 The Charles Stark Draper Laboratory, Inc. Drug delivery apparatus
US7235164B2 (en) 2002-10-18 2007-06-26 Eksigent Technologies, Llc Electrokinetic pump having capacitive electrodes
US7810380B2 (en) 2003-03-25 2010-10-12 Tearlab Research, Inc. Systems and methods for collecting tear film and measuring tear film osmolarity
US8277753B2 (en) 2002-08-23 2012-10-02 Life Technologies Corporation Microfluidic transfer pin
WO2004084263A2 (en) * 2002-09-07 2004-09-30 Arizona Board Of Regents Integrated apparatus and methods for treating liquids
TW536524B (en) * 2002-09-17 2003-06-11 Fan-Gen Tzeng Network-type micro-channel device for micro-fluid
US6881039B2 (en) 2002-09-23 2005-04-19 Cooligy, Inc. Micro-fabricated electrokinetic pump
WO2004029580A2 (en) * 2002-09-25 2004-04-08 Amersham Biosciences (Sv) Corp High density fluidic chip design and method of sample injection
US20040115830A1 (en) * 2002-09-25 2004-06-17 Igor Touzov Components for nano-scale Reactor
TW590982B (en) * 2002-09-27 2004-06-11 Agnitio Science & Technology I Micro-fluid driving device
US20040076408A1 (en) * 2002-10-22 2004-04-22 Cooligy Inc. Method and apparatus for removeably coupling a heat rejection device with a heat producing device
US6994151B2 (en) * 2002-10-22 2006-02-07 Cooligy, Inc. Vapor escape microchannel heat exchanger
JP4282021B2 (ja) * 2002-10-28 2009-06-17 学校法人片柳学園 物質移動の制御方法
US6986382B2 (en) * 2002-11-01 2006-01-17 Cooligy Inc. Interwoven manifolds for pressure drop reduction in microchannel heat exchangers
DE10393588T5 (de) 2002-11-01 2006-02-23 Cooligy, Inc., Mountain View Optimales Ausbreitungssystem, Vorrichtung und Verfahren für flüssigkeitsgekühlten, mikroskalierten Wärmetausch
AU2003283663A1 (en) * 2002-11-01 2004-05-25 Cellectricon Ab Computer programs,workstations, systems and methods for microfluidic substrates in cell
US7836597B2 (en) 2002-11-01 2010-11-23 Cooligy Inc. Method of fabricating high surface to volume ratio structures and their integration in microheat exchangers for liquid cooling system
US7189578B1 (en) 2002-12-02 2007-03-13 Cfd Research Corporation Methods and systems employing electrothermally induced flow for mixing and cleaning in microsystems
JP2004354364A (ja) * 2002-12-02 2004-12-16 Nec Corp 微粒子操作ユニット、それを搭載したチップと検出装置、ならびにタンパク質の分離、捕獲、および検出方法
JP4368804B2 (ja) * 2002-12-02 2009-11-18 ユィロス・パテント・アクチボラグ 微小流体素子の並列処理
ATE397177T1 (de) * 2002-12-04 2008-06-15 Spinx Inc Vorrichtungen und verfahren zur programmierbaren mikrohandhabung von fluiden
FR2848477B1 (fr) * 2002-12-17 2006-03-24 Commissariat Energie Atomique Procede et dispositif de confinement d'un liquide
US7125711B2 (en) * 2002-12-19 2006-10-24 Bayer Healthcare Llc Method and apparatus for splitting of specimens into multiple channels of a microfluidic device
US7094354B2 (en) * 2002-12-19 2006-08-22 Bayer Healthcare Llc Method and apparatus for separation of particles in a microfluidic device
EP1608952B1 (de) 2002-12-20 2016-08-10 Life Technologies Corporation Assay vorrichtung und verfahren unter verwendung von mikrofluiden matrixstrukturen
DE10302720A1 (de) * 2003-01-23 2004-08-05 Steag Microparts Gmbh Mikrofluidischer Schalter zum Anhalten des Flüssigkeitsstroms während eines Zeitintervalls
US6966336B1 (en) 2003-01-24 2005-11-22 Sandia National Laboratories Fluid injection microvalve
US7311882B1 (en) 2003-01-24 2007-12-25 Sandia National Laboratories Capillary interconnect device
US6832787B1 (en) 2003-01-24 2004-12-21 Sandia National Laboratories Edge compression manifold apparatus
US6918573B1 (en) 2003-01-27 2005-07-19 Sandia National Laboratories Microvalve
DE10307227A1 (de) * 2003-02-14 2004-08-26 Cytocentrics Ccs Gmbh Verfahren und Vorrichtung zum Kontaktieren einer Mikrofluidstruktur
SE0300454D0 (sv) * 2003-02-19 2003-02-19 Aamic Ab Nozzles for electrospray ionization and methods of fabricating them
US6926313B1 (en) 2003-04-02 2005-08-09 Sandia National Laboratories High pressure capillary connector
US7553455B1 (en) 2003-04-02 2009-06-30 Sandia Corporation Micromanifold assembly
US20040195099A1 (en) * 2003-04-04 2004-10-07 Jacobson Stephen C. Sample filtration, concentration and separation on microfluidic devices
US7007710B2 (en) * 2003-04-21 2006-03-07 Predicant Biosciences, Inc. Microfluidic devices and methods
US7011793B2 (en) * 2003-05-15 2006-03-14 Kionix, Inc. Reconfigurable modular microfluidic system and method of fabrication
US7435381B2 (en) * 2003-05-29 2008-10-14 Siemens Healthcare Diagnostics Inc. Packaging of microfluidic devices
US7316543B2 (en) * 2003-05-30 2008-01-08 The Board Of Trustees Of The Leland Stanford Junior University Electroosmotic micropump with planar features
US20080257754A1 (en) * 2003-06-27 2008-10-23 Pugia Michael J Method and apparatus for entry of specimens into a microfluidic device
US20040265172A1 (en) * 2003-06-27 2004-12-30 Pugia Michael J. Method and apparatus for entry and storage of specimens into a microfluidic device
US20040265171A1 (en) * 2003-06-27 2004-12-30 Pugia Michael J. Method for uniform application of fluid into a reactive reagent area
US7021369B2 (en) * 2003-07-23 2006-04-04 Cooligy, Inc. Hermetic closed loop fluid system
US7591302B1 (en) 2003-07-23 2009-09-22 Cooligy Inc. Pump and fan control concepts in a cooling system
US7231839B2 (en) * 2003-08-11 2007-06-19 The Board Of Trustees Of The Leland Stanford Junior University Electroosmotic micropumps with applications to fluid dispensing and field sampling
US7347617B2 (en) * 2003-08-19 2008-03-25 Siemens Healthcare Diagnostics Inc. Mixing in microfluidic devices
US7722817B2 (en) * 2003-08-28 2010-05-25 Epocal Inc. Lateral flow diagnostic devices with instrument controlled fluidics
US7407630B2 (en) * 2003-09-19 2008-08-05 Applera Corporation High density plate filler
US20060272738A1 (en) * 2003-09-19 2006-12-07 Gary Lim High density plate filler
US7695688B2 (en) * 2003-09-19 2010-04-13 Applied Biosystems, Llc High density plate filler
US7998435B2 (en) * 2003-09-19 2011-08-16 Life Technologies Corporation High density plate filler
US20060233673A1 (en) * 2003-09-19 2006-10-19 Beard Nigel P High density plate filler
US20050220675A1 (en) * 2003-09-19 2005-10-06 Reed Mark T High density plate filler
US20060233671A1 (en) * 2003-09-19 2006-10-19 Beard Nigel P High density plate filler
US9492820B2 (en) 2003-09-19 2016-11-15 Applied Biosystems, Llc High density plate filler
US20050226782A1 (en) * 2003-09-19 2005-10-13 Reed Mark T High density plate filler
US8277760B2 (en) * 2003-09-19 2012-10-02 Applied Biosystems, Llc High density plate filler
US7537807B2 (en) 2003-09-26 2009-05-26 Cornell University Scanned source oriented nanofiber formation
SG120123A1 (en) * 2003-09-30 2006-03-28 Micron Technology Inc Castellated chip-scale packages and methods for fabricating the same
US20050069949A1 (en) * 2003-09-30 2005-03-31 International Business Machines Corporation Microfabricated Fluidic Structures
US20050069462A1 (en) * 2003-09-30 2005-03-31 International Business Machines Corporation Microfluidics Packaging
US7147362B2 (en) * 2003-10-15 2006-12-12 Agilent Technologies, Inc. Method of mixing by intermittent centrifugal force
US7867194B2 (en) 2004-01-29 2011-01-11 The Charles Stark Draper Laboratory, Inc. Drug delivery apparatus
US7666285B1 (en) 2004-02-06 2010-02-23 University Of Central Florida Research Foundation, Inc. Portable water quality monitoring system
US7569127B1 (en) 2004-02-06 2009-08-04 University Of Central Florida Research Foundation, Inc. Interconnecting microfluidic package and fabrication method
US7592185B2 (en) * 2004-02-17 2009-09-22 Molecular Bioproducts, Inc. Metering doses of sample liquids
CN100434181C (zh) * 2004-02-17 2008-11-19 纳斯申特生物科学公司 计量一定剂量的样品液体
CA2559171A1 (en) 2004-03-12 2005-09-29 Biotrove, Inc. Nanoliter array loading
US20050201895A1 (en) * 2004-03-12 2005-09-15 Eric Donsky Systems and methods for delivering a sample fluid to a receiving substrate
US7187286B2 (en) 2004-03-19 2007-03-06 Applera Corporation Methods and systems for using RFID in biological field
SE0400662D0 (sv) * 2004-03-24 2004-03-24 Aamic Ab Assay device and method
US7575722B2 (en) 2004-04-02 2009-08-18 Eksigent Technologies, Inc. Microfluidic device
US20050227350A1 (en) * 2004-04-13 2005-10-13 Agency For Science, Technology And Research Device and method for studying cell migration and deformation
US7438792B2 (en) * 2004-04-20 2008-10-21 The Regents Of The University Of California Separation system with a sheath-flow supported electrochemical detector
US20050236317A1 (en) * 2004-04-23 2005-10-27 Millipore Corporation Pendant drop control in a multiwell plate
US20050236318A1 (en) * 2004-04-23 2005-10-27 Millipore Corporation Low holdup volume multiwell plate
US20050236319A1 (en) * 2004-04-23 2005-10-27 Millipore Corporation Pendant drop control in a multiwell plate
WO2005120696A1 (ja) * 2004-06-07 2005-12-22 Nano Fusion Technologies, Inc. 電気浸透流ポンプシステム及び電気浸透流ポンプ
EP1611955A1 (de) * 2004-07-01 2006-01-04 Agilent Technologies, Inc. Mikrofluidische Vorrichtung mit Filterkanal
WO2006014460A2 (en) * 2004-07-06 2006-02-09 University Of Utah Research Foundation Spotting device and method for high concentration spot deposition on microarrays and other microscale devices
US20060022130A1 (en) * 2004-07-29 2006-02-02 Predicant Biosciences, Inc., A Delaware Corporation Microfluidic devices and methods with integrated electrical contact
US20060060769A1 (en) * 2004-09-21 2006-03-23 Predicant Biosciences, Inc. Electrospray apparatus with an integrated electrode
US7591883B2 (en) * 2004-09-27 2009-09-22 Cornell Research Foundation, Inc. Microfiber supported nanofiber membrane
EP1827693B1 (de) * 2004-12-09 2010-03-24 Scandinavian Micro Biodevices ApS Mikrofluidvorrichtung und verfahren zur herstellung einer mikrofluidvorrichtung
US7429317B2 (en) * 2004-12-20 2008-09-30 Eksigent Technologies Llc Electrokinetic device employing a non-newtonian liquid
EP1843849A2 (de) * 2005-01-12 2007-10-17 Inverness Medical Switzerland GmbH Verfahren zur herstellung einer mikrofluidischen vorrichtung und mikrofluidische vorrichtungen
KR100682920B1 (ko) * 2005-01-20 2007-02-15 삼성전자주식회사 다중 바이오어세이용 미세유체 칩 및 그 제조방법
WO2006102298A1 (en) * 2005-03-22 2006-09-28 Applera Corporation High density plate filler
CN101213457A (zh) * 2005-03-30 2008-07-02 微流体科技有限公司 电渗透泵和液体馈送装置
JP2006275016A (ja) * 2005-03-30 2006-10-12 Science Solutions International Laboratory Inc 液体輸送装置及び液体輸送システム
US7919323B2 (en) * 2005-06-15 2011-04-05 Rhodia Operations Microfluidic flow devices for determining parameters of physical and/or chemical transformations
FR2890578B3 (fr) * 2005-09-09 2007-11-30 Rhodia Chimie Sa Dispositif d'ecoulement microfluidique permettant de determiner des parametres d'une transformation physique et/ ou chimique, et son utilisation
WO2007005365A2 (en) * 2005-06-29 2007-01-11 Cascade Microtech, Inc. A fluid dispensing system
JP4770312B2 (ja) * 2005-07-26 2011-09-14 トヨタ自動車株式会社 ガスの希釈器
JP2007033167A (ja) * 2005-07-26 2007-02-08 Kagawa Univ バイオケミカルチップとその製造方法
US8383059B2 (en) 2005-09-30 2013-02-26 University Of Utah Research Foundation Microfluidic interface for highly parallel addressing of sensing arrays
WO2007062068A2 (en) 2005-11-23 2007-05-31 Deon Anex, Llp Electrokinetic pump designs and drug delivery systems
CN1987479A (zh) * 2005-12-23 2007-06-27 博奥生物有限公司 阻止液体在亲水性微细管内沿管壁楔角流动的微流体腔体
US7913719B2 (en) 2006-01-30 2011-03-29 Cooligy Inc. Tape-wrapped multilayer tubing and methods for making the same
WO2007102785A1 (en) * 2006-03-09 2007-09-13 Agency For Science, Technology And Research Apparatus for performing a reaction in a droplet and method of using the same
US7535692B2 (en) * 2006-03-28 2009-05-19 Alcatel-Lucent Usa Inc. Multilevel structured surfaces
US8157001B2 (en) 2006-03-30 2012-04-17 Cooligy Inc. Integrated liquid to air conduction module
US7715194B2 (en) 2006-04-11 2010-05-11 Cooligy Inc. Methodology of cooling multiple heat sources in a personal computer through the use of multiple fluid-based heat exchanging loops coupled via modular bus-type heat exchangers
US20070258862A1 (en) * 2006-05-02 2007-11-08 Applera Corporation Variable volume dispenser and method
US8252160B2 (en) * 2006-07-28 2012-08-28 Hewlett-Packard Development Company, L.P. Prevention of fluid delivered to reservoir from wicking into channels within microfluidic device
GB0617035D0 (en) 2006-08-30 2006-10-11 Inverness Medical Switzerland Fluidic indicator device
US9892650B2 (en) * 2006-09-11 2018-02-13 Houghton Mifflin Harcourt Publishing Company Recovery of polled data after an online test platform failure
WO2008052168A2 (en) 2006-10-26 2008-05-02 Symyx Technologies, Inc. High pressure parallel fixed bed reactor and method
US9874501B2 (en) 2006-11-24 2018-01-23 Curiox Biosystems Pte Ltd. Use of chemically patterned substrate for liquid handling, chemical and biological reactions
WO2008063135A1 (en) 2006-11-24 2008-05-29 Agency For Science, Technology And Research Apparatus for processing a sample in a liquid droplet and method of using the same
US8999636B2 (en) * 2007-01-08 2015-04-07 Toxic Report Llc Reaction chamber
EP2101917A1 (de) * 2007-01-10 2009-09-23 Scandinavian Micro Biodevices A/S Mikrofluidische vorrichtung und mikrofluidisches system und verfahren zur testdurchführung
US7867592B2 (en) 2007-01-30 2011-01-11 Eksigent Technologies, Inc. Methods, compositions and devices, including electroosmotic pumps, comprising coated porous surfaces
WO2008094672A2 (en) 2007-01-31 2008-08-07 Charles Stark Draper Laboratory, Inc. Membrane-based fluid control in microfluidic devices
US7799656B2 (en) 2007-03-15 2010-09-21 Dalsa Semiconductor Inc. Microchannels for BioMEMS devices
WO2008124693A1 (en) * 2007-04-05 2008-10-16 The Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University Separation-based arrays
TWI367857B (en) * 2007-05-09 2012-07-11 Nat Univ Tsing Hua Fluidic nano/micro array chip and chipset thereof
US20100294665A1 (en) * 2007-07-12 2010-11-25 Richard Allen Method and system for transferring and/or concentrating a sample
US8016260B2 (en) 2007-07-19 2011-09-13 Formulatrix, Inc. Metering assembly and method of dispensing fluid
TW200924625A (en) 2007-08-07 2009-06-01 Cooligy Inc Deformable duct guides that accommodate electronic connection lines
US8211709B2 (en) * 2007-08-22 2012-07-03 Wisconsin Alumni Research Foundation Method for controlling communication between multiple access ports in a microfluidic device
US20090086064A1 (en) * 2007-09-27 2009-04-02 Micron Technology, Inc. Dynamic adaptive color filter array
US7825337B2 (en) * 2007-10-23 2010-11-02 Slam Brands, Inc. Cable management apparatuses and systems
WO2013114217A1 (en) 2012-02-05 2013-08-08 Curiox Biosystems Pte Ltd. Array plates and methods for making and using same
US10725020B2 (en) 2007-11-14 2020-07-28 Curiox Biosystems Pte Ltd. High throughput miniaturized assay system and methods
US7616917B2 (en) * 2007-11-29 2009-11-10 Eastman Kodak Company Multiple-channeled layer printing by electrography
WO2009076134A1 (en) * 2007-12-11 2009-06-18 Eksigent Technologies, Llc Electrokinetic pump with fixed stroke volume
US8250877B2 (en) 2008-03-10 2012-08-28 Cooligy Inc. Device and methodology for the removal of heat from an equipment rack by means of heat exchangers mounted to a door
US9297571B1 (en) 2008-03-10 2016-03-29 Liebert Corporation Device and methodology for the removal of heat from an equipment rack by means of heat exchangers mounted to a door
WO2009112982A1 (en) * 2008-03-11 2009-09-17 Koninklijke Philips Electronics N.V. Filtering apparatus for filtering a fluid
US20090250347A1 (en) * 2008-04-03 2009-10-08 Protea Biosciences, Inc. Microfluidic devices & processes for electrokinetic transport
US20090250345A1 (en) * 2008-04-03 2009-10-08 Protea Biosciences, Inc. Microfluidic electroelution devices & processes
US9664619B2 (en) * 2008-04-28 2017-05-30 President And Fellows Of Harvard College Microfluidic device for storage and well-defined arrangement of droplets
US8063236B2 (en) * 2008-05-08 2011-11-22 University Of Florida Research Foundation, Inc. Method for transferring N-atoms from metal complexes to organic and inorganic substrates
US8389294B2 (en) * 2008-06-09 2013-03-05 Wisconsin Alumni Research Foundation Microfluidic device and method for coupling discrete microchannels and for co-culture
WO2010017327A1 (en) 2008-08-05 2010-02-11 Cooligy Inc. A microheat exchanger for laser diode cooling
US8287650B2 (en) 2008-09-10 2012-10-16 Applied Materials, Inc. Low sloped edge ring for plasma processing chamber
CA2737627C (en) * 2008-09-22 2018-10-16 Universitaet Zuerich Prorektorat Forschung Hanging drop plate
US8361716B2 (en) * 2008-10-03 2013-01-29 Pathogenetix, Inc. Focusing chamber
US7927904B2 (en) 2009-01-05 2011-04-19 Dalsa Semiconductor Inc. Method of making BIOMEMS devices
US8100293B2 (en) 2009-01-23 2012-01-24 Formulatrix, Inc. Microfluidic dispensing assembly
WO2010104672A2 (en) 2009-03-13 2010-09-16 Illumina Corporation Methods and systems for controlling liquids in multiplex assays
US8784752B2 (en) 2009-04-17 2014-07-22 Curiox Biosystems Pte Ltd Use of chemically patterned substrate for liquid handling, chemical and biological reactions
US9285340B2 (en) * 2009-08-17 2016-03-15 Lawrence Livermore National Security, Llc Methods for separating particles and/or nucleic acids using isotachophoresis
US8145114B2 (en) * 2009-10-29 2012-03-27 Eastman Kodak Company Digital manufacture of a microfluidic device
US8507037B2 (en) * 2009-10-29 2013-08-13 Eastman Kodak Company Digital manufacture of an gas or liquid separation device
US8511889B2 (en) * 2010-02-08 2013-08-20 Agilent Technologies, Inc. Flow distribution mixer
US9878328B2 (en) 2010-07-23 2018-01-30 Curiox Biosystems Pte Ltd. Apparatus and method for multiple reactions in small volumes
EP2611541A4 (de) * 2010-08-31 2016-11-02 Canon Us Life Sciences Inc Verfahren, vorrichtungen und systeme zur mischung von fluiden und chip-schnittstelle dafür
US9114399B2 (en) * 2010-08-31 2015-08-25 Canon U.S. Life Sciences, Inc. System and method for serial processing of multiple nucleic acid assays
KR101190035B1 (ko) 2010-11-18 2012-10-12 케이맥(주) 방사형 필터 구조를 갖는 혈장 분리칩
US8876795B2 (en) 2011-02-02 2014-11-04 The Charles Stark Draper Laboratory, Inc. Drug delivery apparatus
WO2012151586A1 (en) 2011-05-05 2012-11-08 Eksigent Technologies, Llc Gel coupling for electrokinetic delivery systems
US20160102281A1 (en) * 2011-08-29 2016-04-14 Universität Zürich Prorektorat Forschung Hanging drop plate
EP2751021A4 (de) * 2011-08-30 2015-09-30 Univ Mcgill Verfahren und system für vorprogrammierte und selbstangetriebene mikrofluidische schaltungen
KR20130058954A (ko) * 2011-11-28 2013-06-05 삼성전기주식회사 배양 용기 및 이의 시료 주입 방법
US8685708B2 (en) 2012-04-18 2014-04-01 Pathogenetix, Inc. Device for preparing a sample
US9028776B2 (en) 2012-04-18 2015-05-12 Toxic Report Llc Device for stretching a polymer in a fluid sample
US9976417B2 (en) 2012-07-16 2018-05-22 Schlumberger Technology Corporation Capillary electrophoresis for reservoir fluid analysis at wellsite and laboratory
US10300450B2 (en) 2012-09-14 2019-05-28 Carterra, Inc. Method and device for depositing a substance on a submerged surface
CN110243637B (zh) 2013-03-14 2022-06-24 小利兰·斯坦福大学托管委员会 用于微流体装置分段装载的毛细屏障
US9267938B2 (en) 2013-03-14 2016-02-23 The Trustees Of The Stevens Institute Of Technology Ex vivo human multiple myeloma cancer niche and its use as a model for personalized treatment of multiple myeloma
WO2014183118A1 (en) * 2013-05-10 2014-11-13 The Regents Of The University Of California Digital microfluidic platform for creating, maintaining and analyzing 3-dimensional cell spheroids
KR20140144408A (ko) * 2013-06-11 2014-12-19 삼성전기주식회사 액적 형성 장치 및 이를 이용한 액적 형성 방법
US9557318B2 (en) 2013-07-09 2017-01-31 Curiox Biosystems Pte Ltd. Array plates for washing samples
TWI511790B (zh) * 2013-07-11 2015-12-11 Univ Nat Taiwan 具有電極陣列的微流道元件
US10018590B2 (en) 2013-08-15 2018-07-10 Schlumberger Technology Corporation Capillary electrophoresis for subterranean applications
US9550016B2 (en) * 2014-01-20 2017-01-24 Halcyon Biomedical, Incorporated Passive separation of whole blood
JP6636686B2 (ja) * 2014-07-09 2020-01-29 株式会社エンプラス 流体取扱装置の取扱方法
EP3792615A1 (de) 2014-09-23 2021-03-17 Tearlab Research, Inc. System zur integration einer mikrofluidischen tränenprobenahme und lateral-flow-analyse von interessierenden analyten
CN107108199B (zh) * 2014-11-11 2020-01-10 微研生物科技有限公司 用于研究基于细胞的相互作用的微流体平台
US10330218B2 (en) * 2015-02-09 2019-06-25 President And Fellows Of Harvard College Fluid-based gating mechanism with tunable multiphase selectivity and antifouling behavior
US10545139B2 (en) 2015-06-16 2020-01-28 Curiox Biosystems Pte Ltd. Methods and devices for performing biological assays using magnetic components
US9956558B2 (en) 2015-07-24 2018-05-01 HJ Science & Technology, Inc. Reconfigurable microfluidic systems: homogeneous assays
US9956557B2 (en) 2015-07-24 2018-05-01 HJ Science & Technology, Inc. Reconfigurable microfluidic systems: microwell plate interface
US9733239B2 (en) 2015-07-24 2017-08-15 HJ Science & Technology, Inc. Reconfigurable microfluidic systems: scalable, multiplexed immunoassays
EP3179243B1 (de) * 2015-12-09 2023-09-27 ARKRAY, Inc. Analytisches werkzeug und analytisches system
JP6595439B2 (ja) * 2015-12-09 2019-10-23 アークレイ株式会社 分析用具および分析システム
CN116083530A (zh) 2016-01-29 2023-05-09 普瑞珍生物***公司 用于核酸纯化的等速电泳
WO2018185554A1 (en) 2017-04-05 2018-10-11 Curiox Biosystems Pte Ltd. Methods, devices, and apparatus for washing samples on array plates
EP3633365B1 (de) * 2017-05-31 2023-02-22 Shimadzu Corporation Probenplatte für eine pesi-ionenquelle und massenspektrometer mit dieser probenplatte
AU2018312570B2 (en) 2017-08-02 2024-01-11 Purigen Biosystems, Inc. Systems, devices, and methods for isotachophoresis
JP7317026B2 (ja) 2018-01-30 2023-07-28 ライフ テクノロジーズ コーポレーション スマート分子分析システムのワークフローにおける使用のための機器、デバイス、および消耗品
US11376589B2 (en) 2018-04-30 2022-07-05 Protein Fluidics, Inc. Valveless fluidic switching flowchip and uses thereof
US10685906B2 (en) 2018-11-13 2020-06-16 International Business Machines Corporation Electrically conductive deterministic lateral displacement array in a semiconductor device
US11548000B2 (en) 2018-11-28 2023-01-10 International Business Machines Corporation Structures for automated, multi-stage processing of nanofluidic chips
US10490482B1 (en) * 2018-12-05 2019-11-26 Toyota Motor Engineering & Manufacturing North America, Inc. Cooling devices including jet cooling with an intermediate mesh and methods for using the same
BE1027013B1 (nl) * 2019-01-31 2020-09-01 Pharmafluidics N V Filter voor chemische reactoren
WO2020251526A1 (en) * 2019-06-10 2020-12-17 Instant Nanobiosensors, Inc. Microfluidic detection unit and fluid detection method

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3980541A (en) * 1967-06-05 1976-09-14 Aine Harry E Electrode structures for electric treatment of fluids and filters using same
US3799742A (en) * 1971-12-20 1974-03-26 C Coleman Miniaturized integrated analytical test container
US4225410A (en) * 1978-12-04 1980-09-30 Technicon Instruments Corporation Integrated array of electrochemical sensors
US4426451A (en) * 1981-01-28 1984-01-17 Eastman Kodak Company Multi-zoned reaction vessel having pressure-actuatable control means between zones
US4480031A (en) * 1981-11-02 1984-10-30 Shaw Joseph R H Replicator with slidable pins
US4517089A (en) * 1982-09-29 1985-05-14 Hydrotreat, Inc. Method and apparatus for constructing filter element
US4654127A (en) * 1984-04-11 1987-03-31 Sentech Medical Corporation Self-calibrating single-use sensing device for clinical chemistry and method of use
AU583040B2 (en) * 1984-06-13 1989-04-20 Applied Research Systems Ars Holding N.V. Devices for use in chemical test procedures
US4686041A (en) * 1984-11-26 1987-08-11 Den Berg Teunis T Van Molecular differentiation filter
US4676274A (en) * 1985-02-28 1987-06-30 Brown James F Capillary flow control
US4963498A (en) * 1985-08-05 1990-10-16 Biotrack Capillary flow device
US4726900A (en) * 1986-07-29 1988-02-23 Vacco Industries Stacked sheet filter element
US4795560A (en) * 1987-04-16 1989-01-03 The Black Clawson Company Screen plates
US5503803A (en) * 1988-03-28 1996-04-02 Conception Technologies, Inc. Miniaturized biological assembly
US4908112A (en) * 1988-06-16 1990-03-13 E. I. Du Pont De Nemours & Co. Silicon semiconductor wafer for analyzing micronic biological samples
US5108704A (en) * 1988-09-16 1992-04-28 W. R. Grace & Co.-Conn. Microfiltration apparatus with radially spaced nozzles
GB8829603D0 (en) * 1988-12-19 1989-02-08 New Domain Limited Improvements in or relating to lift shafts
US5262128A (en) * 1989-10-23 1993-11-16 The United States Of America As Represented By The Department Of Health And Human Services Array-type multiple cell injector
AU642444B2 (en) * 1989-11-30 1993-10-21 Mochida Pharmaceutical Co., Ltd. Reaction vessel
US5770029A (en) * 1996-07-30 1998-06-23 Soane Biosciences Integrated electrophoretic microdevices
SE470347B (sv) * 1990-05-10 1994-01-31 Pharmacia Lkb Biotech Mikrostruktur för vätskeflödessystem och förfarande för tillverkning av ett sådant system
US5147606A (en) * 1990-08-06 1992-09-15 Miles Inc. Self-metering fluid analysis device
EP0484278B1 (de) * 1990-11-01 1995-04-12 Ciba-Geigy Ag Vorrichtung zur Aufbereitung oder Vorbereitung von flüssigen Proben für eine chemische Analyse
DE59108006D1 (de) * 1991-01-28 1996-08-22 Ciba Geigy Ag Vorrichtung zur Vorbereitung von Proben insbesondere für Analysezwecke
SE9100392D0 (sv) * 1991-02-08 1991-02-08 Pharmacia Biosensor Ab A method of producing a sealing means in a microfluidic structure and a microfluidic structure comprising such sealing means
US5143496A (en) * 1991-02-22 1992-09-01 Superior Trailer Works, Inc. Latching system for transfer truck and trailer set
US5486335A (en) * 1992-05-01 1996-01-23 Trustees Of The University Of Pennsylvania Analysis based on flow restriction
US5304487A (en) * 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
US5296375A (en) * 1992-05-01 1994-03-22 Trustees Of The University Of Pennsylvania Mesoscale sperm handling devices
US5639423A (en) * 1992-08-31 1997-06-17 The Regents Of The University Of Calfornia Microfabricated reactor
US5482608A (en) * 1993-01-19 1996-01-09 Hewlett Packard Company Capillary electrophoresis flow control system
EP1296134B1 (de) * 1993-04-15 2013-05-29 Bayer Intellectual Property GmbH Probenentnahmevorrichtung und deren Verwendung zur Steuerung der Probeneinführung bei Mikrosäulentrennungstechniken
US5427663A (en) * 1993-06-08 1995-06-27 British Technology Group Usa Inc. Microlithographic array for macromolecule and cell fractionation
US5604487A (en) * 1993-07-30 1997-02-18 Lockheed Martin Tactical Systems, Inc. Apparatus and method for user-selective data communication with verification
RU2041263C1 (ru) * 1993-08-11 1995-08-09 Геннадий Моисеевич Ершов Способ микродозирования водных растворов веществ на носитель и устройство для его осуществления
US5429734A (en) * 1993-10-12 1995-07-04 Massachusetts Institute Of Technology Monolithic capillary electrophoretic device
US6129828A (en) * 1996-09-06 2000-10-10 Nanogen, Inc. Apparatus and methods for active biological sample preparation
SE9400437D0 (sv) * 1994-02-10 1994-02-10 Pharmacia Lkb Biotech Filterbrunn och förfarande vid dess tillverkning
US5513757A (en) * 1994-06-02 1996-05-07 Sulzer Papertec Mansfield Inc. Continuous cut slotted screen basket
US6001229A (en) * 1994-08-01 1999-12-14 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing microfluidic manipulations for chemical analysis
US5517956A (en) 1994-08-11 1996-05-21 Del West Engineering, Inc. Titanium engine valve
US5571410A (en) * 1994-10-19 1996-11-05 Hewlett Packard Company Fully integrated miniaturized planar liquid sample handling and analysis device
US5500071A (en) * 1994-10-19 1996-03-19 Hewlett-Packard Company Miniaturized planar columns in novel support media for liquid phase analysis
US5603351A (en) * 1995-06-07 1997-02-18 David Sarnoff Research Center, Inc. Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device
DK0725267T3 (da) * 1995-02-01 1999-08-02 Rossendorf Forschzent Elektrisk styrbar mikropipette
US5560811A (en) * 1995-03-21 1996-10-01 Seurat Analytical Systems Incorporated Capillary electrophoresis apparatus and method
JP3375780B2 (ja) * 1995-03-29 2003-02-10 三井化学株式会社 重包装袋用ポリエチレン樹脂組成物およびその組成物からなる重包装袋用ポリエチレン樹脂フィルム
US5856174A (en) * 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US5958344A (en) * 1995-11-09 1999-09-28 Sarnoff Corporation System for liquid distribution
US5942443A (en) 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
US5885470A (en) * 1997-04-14 1999-03-23 Caliper Technologies Corporation Controlled fluid transport in microfabricated polymeric substrates
US5779868A (en) 1996-06-28 1998-07-14 Caliper Technologies Corporation Electropipettor and compensation means for electrophoretic bias
US5766193A (en) * 1996-11-05 1998-06-16 Millner; Don E. Tongue cleaner
DE19782096T1 (de) * 1996-11-06 2000-03-23 Sequenom Inc Immobiliserung von Nucleinsäuren in hoher Dichte
US5904824A (en) * 1997-03-07 1999-05-18 Beckman Instruments, Inc. Microfluidic electrophoresis device
US6143496A (en) * 1997-04-17 2000-11-07 Cytonix Corporation Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
US6090251A (en) * 1997-06-06 2000-07-18 Caliper Technologies, Inc. Microfabricated structures for facilitating fluid introduction into microfluidic devices
US5882930A (en) * 1997-11-10 1999-03-16 Hyseq, Inc. Reagent transfer device
ATE477850T1 (de) * 1998-01-12 2010-09-15 Massachusetts Inst Technology Vorrichtung zur mikrotestdurchführung
US7207263B2 (en) 2003-01-21 2007-04-24 Frito-Lay North America, Inc. Single mold form fryer with product centering elements
WO2007025267A2 (en) 2005-08-25 2007-03-01 Gatekeeper Systems, Inc. Systems and methods for locating and controlling powered vehicles

Also Published As

Publication number Publication date
AU7820798A (en) 1998-12-21
US20070102297A1 (en) 2007-05-10
US6090251A (en) 2000-07-18
US20070110633A1 (en) 2007-05-17
US20070092400A1 (en) 2007-04-26
US20020084185A1 (en) 2002-07-04
US20020179447A1 (en) 2002-12-05
US6086825A (en) 2000-07-11
WO1998055852A1 (en) 1998-12-10
US7259020B2 (en) 2007-08-21
US20060286001A1 (en) 2006-12-21
US20070102296A1 (en) 2007-05-10
US6451188B1 (en) 2002-09-17
US7399448B2 (en) 2008-07-15
US20020185377A1 (en) 2002-12-12
EP0988530A1 (de) 2000-03-29
EP0988530B1 (de) 2012-05-02
CA2290633A1 (en) 1998-12-10
EP0988530A4 (de) 2002-10-30
AU734146B2 (en) 2001-06-07
US20060286000A1 (en) 2006-12-21
US6709559B2 (en) 2004-03-23
US7364706B2 (en) 2008-04-29
US7364704B2 (en) 2008-04-29
US7364915B2 (en) 2008-04-29
US7364705B2 (en) 2008-04-29
US20070102295A1 (en) 2007-05-10
US7364703B2 (en) 2008-04-29
US20060286002A1 (en) 2006-12-21
US7364916B2 (en) 2008-04-29

Similar Documents

Publication Publication Date Title
ATE556315T1 (de) Mikrohergestellte strukturen um die einführung von fluiden in mikrofluidischen systemen zu erleichtern
ATE424552T1 (de) Kapillar-ventil-verbindungsstück und die flu richtung bestimmendes kapillar-element
DE60336841D1 (de) Mischkammer
DE60007128D1 (de) Polymerventile
WO2003078972A8 (en) Ribbon flow cytometry and cell sorting
ATE347692T1 (de) Integrierte mikrofluidische vorrichtungen
DE60236892D1 (de) "verbesserte bedingungen für fluidtrennungen in mikrokanälen, kapillarangetriebene fluidtrennungen"
ATE410686T1 (de) Screening-testsystem mit hohem durchfluss durch mikrofluidische vorrichtungen
ES2176308T3 (es) Dispositivo de microestructura porosa que permite un flujo.
WO2003035229A3 (en) Integrated fluidic device for sample preparation and assay
CA2287409A1 (en) Microfluidic devices incorporating improved channel geometries
MX9700845A (es) Aparato y metodo para llevar a cabo manipulaciones de microfluidos para analisis y sintesis quimicos.
DE60040977D1 (de) Flüssigkeitswechsel in einer kammer auf einem mikroskopobjektträger
ATE445155T1 (de) Mikrofluidische vorrichtung mit einer flüssigproben-injektionseinrichtung und verwendungsverfahren
ATE360597T1 (de) Ventil zur verwendung in mikrofluiden strukturen
WO2002022266A3 (en) Fluid cartridge and method
WO2002065565A3 (en) Flow field plate geometries
DE60209617D1 (de) Quantitative Multiplex-PCR mit grossem Dynamikbereich
WO2002063288A8 (en) Microfluidic devices
DE60210600D1 (de) Mikrofluidfraktionssammler
BR0106069A (pt) Dispositivo para determinar pelo menos um parâmetro de um meio corrente e um processo para separar um lìquido de um meio corrente em uma tubulação
SE9702005D0 (sv) New reaction vessel and method for its use
ATE317281T1 (de) Verfahren und trennmodul zum abtrennen von partikeln aus einer dispersion, insbesondere von blutkörperchen aus blut
EP1724007A3 (de) Mischvorrichtung für Fluide unter Verwendung von Querkanälen
DK1597576T3 (da) Kapillarstop